Sample records for nasa adn mcdonnell
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DOD Recovery personnel and NASA technicians inspect Friendship 7 spacecraft
1964-01-01
Department of Defense Recovery personnel and spacecraft technicians from NASA adn McDonnell Aircraft Corp., inspect Astronaut John Glenn's Mercury spacecraft, Friendship 7, following its return to Cape Canaveral after recovery in the Atlantic Ocean.
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Detonation velocity of melt-cast ADN and ADN/nano-diamond cylinders
Doherty, R. M.; Forbes, J. W.; Lawrence, G. W.; Deiter, J. S.; Baker, R. N.; Ashwell, K. D.; Sutherland, G. T.
2000-04-01
Detonation velocities of confined cylinders of melt-cast ADN/ZnO (99.5/0.5 by weight), ADN/nano-diamond/ZnO (92.4/7.2/0.4), ADN/AN/ZnO (95.5/4.0/0.5) and ADN/AN/ZnO/nano-diamond (88.0/4.5/0.5/7.0) have been measured using a streak camera. Velocities ranging between 3.9 and 4.5 mm/μs were obtained for 1.3 cm diameter samples confined by steel and a 2.5 cm diameter ADN/AN/ZnO cylinder. In one of the samples the detonation was failing as it proceeded through the charge. For the other shots reported, the shock velocities appeared to be steady through the last half of the charge, though the lengths were too short for any definitive statement about the failure diameter to be made.
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Ammonium dinitramide (ADN)-Prilling, coating, and characterization
Energy Technology Data Exchange (ETDEWEB)
Heintz, Thomas; Pontius, Heike; Aniol, Jasmin; Birke, Christoph; Leisinger, Karlfred; Reinhard, Werner [Fraunhofer-Institut Chemische Technologie ICT, Pfinztal (Germany)
2009-06-15
Ammonium dinitramide (ADN) is the promising oxidizer, which is expected to be applied, e.g., in solid rocket propellants. The manufacturing of spherical ADN particles (the so-called ADN-Prills) with useful morphology and reproducible quality is realized by means of the emulsion crystallization process. (Abstract Copyright [2009], Wiley Periodicals, Inc.)
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Formulation and Characterization of ADN-Based Liquid Monopropellants
Wingborg, N.; Eldsäter, C.; Skifs, H.
2004-10-01
Ternary ionic solutions are promising green propellants to replace monopropellant hydrazine. Ammonium dinitramide, ADN, is well suited as oxidizer in these propellants due to its high solubility. This paper presents the formulation of different ADN-based liquid monopropellants and the characterization of their properties such as stability, density, viscosity and sensitivity. To be able to use ADN-based monopropellants for propulsion applications, ADN must be produced in a way to minimize the effect on the environment and in sufficient quantities. This paper thus also briefly presents the industrial production of ADN in Sweden and the efforts made to optimize the process.
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Dysrhythmia management content in ADN and BSN curricula.
McIntosh, Trisha; Duske, Shawna; Anderson, Mary Ann; Hill, Pamela
2008-07-01
The purposes of this study were to compare nurse educators' perceptions of the importance of selected dysrhythmia management competencies for the graduates of associate degree in nursing (ADN) and baccalaureate of science in nursing (BSN) programs, and to compare what related content is taught at the ADN and BSN level for dysrhythmia management. A quantitative, nonexperimental design with a mailed survey was used to compare how nurse educators perceive the importance of dysrhythmia competencies in selected ADN and BSN programs in the states of Illinois and Iowa, and to determine what related content is taught. A total of 33 ADN and 24 BSN programs returned the survey for a 58.2% (57 of 98) response rate. Results indicated that ADN and BSN faculty in Illinois and Iowa perceived that selected dysrhythmia management content is important and that such content is currently provided at both the ADN and BSN level. Health care institutions can have confidence that new graduates from either educational preparation have had dysrhythmia management content and can expand their level of expertise.
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75 FR 50878 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes
2010-08-18
... Airworthiness Directives; McDonnell Douglas Corporation Model MD- 90-30 Airplanes AGENCY: Federal Aviation... McDonnell Douglas Corporation: Amendment 39-16388. Docket No. FAA-2010-0433; Directorate Identifier 2009-NM..., 2010. Affected ADs (b) None. Applicability (c) This AD applies to McDonnell Douglas Corporation Model...
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75 FR 68245 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes
2010-11-05
...-1043; Directorate Identifier 2010-NM-200-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... McDonnell Douglas Model MD-90-30 airplanes. This proposed AD would require installing new fire handle... airworthiness directive (AD): McDonnell Douglas Corporation: Docket No. FAA-2010-1043; Directorate Identifier...
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75 FR 21528 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes
2010-04-26
...-0433; Directorate Identifier 2009-NM-117-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... main landing gear (MLG) during gear extension, damaging the hydraulic system on McDonnell Douglas.... The retract cylinder support fittings for the MLG on McDonnell Douglas Model MD-80 series airplanes...
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Fundamentos de computación con ADN
Directory of Open Access Journals (Sweden)
Jorge Eduardo Ortíz Triviño
1998-05-01
Full Text Available Este artículo presenta algunas ideas básicas para resolver problemas computacionales complejos, mediante el empleo de la estructura biológica del ADN y técnicas especializadas de laboratorio. Las características del ADN que se describen hacen posible codificar estructuras matemáticas, como las máquinas de Turing o las redes neuronales; para ello, la clave está en la interpretación del ADN como un generador de lenguajes.
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75 FR 66653 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes
2010-10-29
... Airworthiness Directives; McDonnell Douglas Corporation Model MD- 90-30 Airplanes AGENCY: Federal Aviation...-15667 (73 FR 52203, September 9, 2008), and adding the following new AD: 2010-22-04 McDonnell Douglas... supersedes AD 2008-18-10, Amendment 39-15667. Applicability (c) This AD applies to McDonnell Douglas...
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DNA Open states and DNA hydratation; Estados abiertos del ADN e hidratacion del ADN
Energy Technology Data Exchange (ETDEWEB)
Lema-Larre, B de [Universidad Central de Venezuela (UCV), Facultad de Medicina, Caracas (Venezuela); Martin-Landrove, M [Universidad Central de Venezuela (UCV), Facultad de Ciencias, Centro de Resonancia Magnetica Caracas (Venezuela)
1995-07-01
It is a very well-known fact that an protonic exchange exists among natural DNA filaments and synthetic polynucleotides with the solvent (1--2). The existence of DNA open states, that is to say states for which the interior of the DNA molecule is exposed to the external environment, it has been demonstrated by means of proton-deuterium exchange (3). This work has carried out experiments measuring the dispersion of the traverse relaxation rate (4), as a pulsation rate function in a Carr-Purcell-Meiboom-Gill (CPMG) pulses sequence rate, to determine changes in the moist layer of the DNA molecule. The experiments were carried out under different experimental conditions in order to vary the probability that open states occurs, such as temperature or the exposure to electromagnetic fields. Some theoretical models were supposed to adjust the experimental results including those related to DNA non linear dynamic. [Spanish] Es un hecho bien conocido que existe un intercambio protonico entre filamentos naturales de ADN y polinucleotidos sinteticos con el solvente (1--2). La existencia de estados abiertos en el ADN, es decir estados para los cuales el interior de la molecula del ADN es expuesto al ambiente exterior, ha sido demostrado mediante experimentos de intercambio proton-deuterio (3). En el presente trabajo hemos realizado experimentos midiendo la dispersion de la tasa de relajacion transversal (4), como una funcion de la tasa de pulsacion en una secuencia de pulsos de Carr-Purcell-Meiboom-Gill (CPMG), para determinar cambios en la capa de hidratacion de la molecula de ADN. Los experimentos fueron realizados bajo diferentes condiciones experimentales para asi variar la probabilidad de que ocurran estados abiertos, tales como la temperatura o la exposicion a campos electromagneticos. Algunos modelos teoricos fueron supuestos para ajustar los resultados experimentales incluyendo aquellos relacionados con dinamica no lineal del ADN. (autor)
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75 FR 38056 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes
2010-07-01
...-0645; Directorate Identifier 2009-NM-200-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas..., September 9, 2008), for certain McDonnell Douglas Corporation Model MD-90-30 airplanes. That AD requires a... fasteners in the aft mount support fitting of the left and right engines on 29 McDonnell Douglas Corporation...
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Formulation and properties of ADN/GAP propellants
Energy Technology Data Exchange (ETDEWEB)
Menke, Klaus; Heintz, Thomas; Schweikert, Wenka; Keicher, Thomas; Krause, Horst [Fraunhofer-Institut fuer Chemische Technologie ICT, Pfinztal (Germany)
2009-06-15
In this contribution two ways are described, how it is possible to achieve perfectly cured and processible propellants with prilled ADN, low amounts of HMX 5{mu}m mps and a binder system based on GAP diole and GAP triole oligomers with and without TMETN as a nitrate ester plasticizer. It was shown how it will be possible to suppress the strongly gas forming reaction between ADN and reactive isocyanates by a mixture of stabilizers. In this way it was possible to create minimum smoke ADN/HMX/GAP/TMETN propellants cured with the triisocyanate N100. In the second part an unconventional binder system based on the 1.3 dipolar cycloaddition reaction of azido groups with acetylene compounds forming 1,2,3-triazole heterocyclic rings has been applied for ADN/GAP and AP/GAP propellants. Together with small parts of HMX formulations with ADN/HMX/GAP and the corresponding AP/HMX/GAP exhibit high thermodynamic performance, are easily processible, and cure successfully at 60 C. Their basic properties consisting of burning behavior and mechanical properties, at ambient temperature, chemical stability, and sensitivity have been investigated and are compared to each other. (Abstract Copyright [2009], Wiley Periodicals, Inc.)
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Improving Clinical Teaching: The ADN Experience. Pathways to Practice.
Haase, Patricia T.; And Others
Three Florida associate degree in nursing (ADN) demonstration projects of the Nursing Curriculum Project (NCP) are described, and the history of the ADN program and current controversies are reviewed. In 1976, the NCP of the Southern Regional Education Board issued basic assumptions about the role of the ADN graduate, relating them to client…
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Santhosh, G; Venkatachalam, S; Ninan, K N; Sadhana, R; Alwan, S; Abarna, V; Joseph, M A
2003-03-17
Investigations on the adsorption of ammonium dinitramide (NH(4)N(NO(2))(2)) (ADN) from aqueous solutions on powdered activated charcoal (PAC) were carried out in order to find out an effective and easier method of separating ADN from aqueous solutions. The effectiveness of PAC in the selective adsorption of ADN from aqueous solutions of ADN (ADN-F) and ADN in presence of sulfate (SO(4)(2-)) and nitrate (NO(3)(-)) ions (ADN-PS) was examined and compared using batch and column methods. The adsorption process follows both Langmuir and Freundlich adsorption isotherms and the isotherm parameters for the models were determined. The observed data favor the formation of monolayer adsorption. The adsorption capacities were found to be 63.3, 119, 105.3 and 82 mg of ADN per g of PAC for ADN-F (batch), ADN-PS (batch), ADN-F (column) and ADN-PS (column), respectively. Break-through curves for ADN-F and ADN-PS were obtained for the optimization of separation of ADN from aqueous solutions. Elution curves were generated for the desorption of ADN from PAC using hot water as eluent. Copyright 2003 Elsevier Science B.V.
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The Properties of Ammonium Dinitramine (ADN): Part 2: Melt Casting
Hahma, A.; Edvinsson, H.; Östmark, H.
2010-04-01
A melt casting technique for ammonium dinitramine (ADN) and ADN/aluminum was developed. ADN proved relatively easy to cast, when 1% of magnesium oxide was used as a stabilizer and crystallization kernels. Densities of ADN/MgO 99/1 were 92 to 97% of theoretical mean density (TMD) and those of ADN/Al/MgO 64/35/1 were between 95 and 99% of TMD. Sedimentation of Al in the melt was prevented and the particle wetting was ensured by selecting a suitable particle size for Al. No gelling agents or other additives were used. The casting process and factors influencing it are discussed.
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Differences in clinical experiences of ADN and BSN students.
Oermann, M H
1998-05-01
Prior research has suggested that clinical experience for nursing students is stressful. Concern about making an error and harming the patient, limited knowledge and skills for practice, and difficulties in interacting with the teacher and others in the clinical setting are some of the stressors reported by students. Few studies have compared these stresses and the clinical experiences in general between students in associate degree (ADN) and baccalaureate (BSN) nursing programs. The purposes of this research were to compare the clinical experiences of ADN and BSN students at different levels in the programs and describe these experiences from the students' perspectives. As such, both quantitative and qualitative data were collected from 415 students in ADN and BSN programs in the Midwest. The ADN students reported significantly higher stress in clinical practice than BSN students (t = 2.16, p ADN and BSN students in clinical practice increased as they progressed through the programs. The semester prior to graduation was the most stressful time in terms of clinical practice for both ADN and BSN students. The instructor was the predominant stressor reported by students in ADN programs across all levels of the curriculum. Among BSN students, the most prevalent stresses were coping with demands associated with patient care and the clinical teacher. The findings highlight the important role of the clinical faculty in both types of nursing programs.
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2012-08-29
... Airworthiness Directives; Hughes Helicopters, Inc., and McDonnell Douglas Helicopter Systems (Type Certificate... Airworthiness Directive (AD): Hughes Helicopters Inc., and McDonnel Douglas Helicopter Systems (Type Certificate...
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2013-03-26
... Airworthiness Directives; Hughes Helicopters, Inc., and McDonnell Douglas Helicopter Systems (Type Certificate... directive (AD): 2013-05-16 Hughes Helicopters, Inc., and McDonnell Douglas Helicopter Systems (Type...
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Quimera de ADN polimerasa del fago ϕ29
Salas, Margarita; Vega, Miguel de; Lázaro, José M.; Blanco, Luis; Mencía, Mario
2010-01-01
Quimera de ADN polimerasa del fago 29. La presente invención se encuadra dentro del campo de la biotecnología. Específicamente, se refiere a una quimera de ADN polimerasa que comprende una región aminoterminal (N-terminal), que codifica para una ADN polimerasa del tipo 29, y una región carboxilo-terminal (C-terminal), que comprende, al menos, un dominio HhH, que se encuentran unidas mediante una secuencia aminoacídica conectora y a su uso para la replicación, amplifi...
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Effets des electrons secondaires sur l'ADN
Boudaiffa, Badia
Les interactions des electrons de basse energie (EBE) representent un element important en sciences des radiations, particulierement, les sequences se produisant immediatement apres l'interaction de la radiation ionisante avec le milieu biologique. Il est bien connu que lorsque ces radiations deposent leur energie dans la cellule, elles produisent un grand nombre d'electrons secondaires (4 x 104/MeV), qui sont crees le long de la trace avec des energies cinetiques initiales bien inferieures a 20 eV. Cependant, il n'y a jamais eu de mesures directes demontrant l'interaction de ces electrons de tres basse energie avec l'ADN, du principalement aux difficultes experimentales imposees par la complexite du milieu biologique. Dans notre laboratoire, les dernieres annees ont ete consacrees a l'etude des phenomenes fondamentaux induits par impact des EBE sur differentes molecules simples (e.g., N2, CO, O2, H2O, NO, C2H 4, C6H6, C2H12) et quelques molecules complexes dans leur phase solide. D'autres travaux effectues recemment sur des bases de l'ADN et des oligonucleotides ont montre que les EBE produisent des bris moleculaires sur les biomolecules. Ces travaux nous ont permis d'elaborer des techniques pour mettre en evidence et comprendre les interactions fondamentales des EBE avec des molecules d'interet biologique, afin d'atteindre notre objectif majeur d'etudier l'effet direct de ces particules sur la molecule d'ADN. Les techniques de sciences des surfaces developpees et utilisees dans les etudes precitees peuvent etre etendues et combinees avec des methodes classiques de biologie pour etudier les dommages de l'ADN induits par l'impact des EBE. Nos experiences ont montre l'efficacite des electrons de 3--20 eV a induire des coupures simple et double brins dans l'ADN. Pour des energies inferieures a 15 eV, ces coupures sont induites par la localisation temporaire d'un electron sur une unite moleculaire de l'ADN, ce qui engendre la formation d'un ion negatif transitoire
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ADN to BSN: lessons from human capital theory.
Graf, Christina M
2006-01-01
Currently, approximately 16% of associate degree nursing (ADN) graduates acquire baccalaureate or higher degrees. Human capital analysis demonstrated negative to minimal average returns on investment (ROI) in BSN education. Increasing the ROI may influence ADNs to pursue baccalaureate education and can be an effective strategy for meeting the projected need for BSN-prepared nurses.
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75 FR 80742 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes
2010-12-23
...-1202; Directorate Identifier 2010-NM-167-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... amends Sec. 39.13 by adding the following new airworthiness directive (AD): McDonnell Douglas Corporation... Douglas Corporation Model MD-90-30 airplanes, certificated in any category. Subject (d) Joint Aircraft...
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2010-08-05
... Airworthiness Directives; McDonnell Douglas Corporation Model DC- 9-10 Series Airplanes, DC-9-30 Series... existing airworthiness directive (AD), which applies to all McDonnell Douglas Model DC-9-10 series..., 2010). That AD applies to all McDonnell Douglas Corporation Model DC-9-10 series airplanes, DC-9-30...
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2010-08-05
... Airworthiness Directives; McDonnell Douglas Corporation Model MD- 11 and MD-11F Airplanes Equipped With General... Sec. 39.13 by adding the following new AD: 2010-16-03 McDonnell Douglas Corporation: Amendment 39... applies to McDonnell Douglas Corporation Model MD-11 and MD-11F airplanes, certified in any category...
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75 FR 36577 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes
2010-06-28
... Airworthiness Directives; McDonnell Douglas Corporation Model MD- 90-30 Airplanes AGENCY: Federal Aviation... Douglas Corporation: Docket No. FAA-2010-0554; Directorate Identifier 2010-NM-082-AD. Comments Due Date (a... supersedes AD 2009-07-04, Amendment 39-15863. Applicability (c) This AD applies to McDonnell Douglas...
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2010-07-01
... Airworthiness Directives; McDonnell Douglas Corporation Model DC- 9-10 Series Airplanes, DC-9-30 Series... previously to all known U.S. owners and operators of the McDonnell Douglas Corporation airplanes identified... INFORMATION: On July 15, 2009, we issued AD 2009-15-16, which applies to all McDonnell Douglas Model DC-9-10...
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Modelos de computación lógica con ADN
Sainz de Murieta Fuentes, Iñaki
2011-01-01
La computación molecular es una disciplina que se ocupa del diseño e implementación de dispositivos para el procesamiento de información sobre un sustrato biológico, como el ácido desoxirribonucleico (ADN), el ácido ribonucleico (ARN) o las proteínas. Desde que Watson y Crick descubrieron en los años cincuenta la estructura molecular del ADN en forma de doble hélice, se desencadenaron otros descubrimientos como las enzimas que cortan el ADN o la reacción en cadena de la polimerasa (PCR), cont...
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2010-02-08
...-1213; Directorate Identifier 2009-NM-097-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas...: We propose to adopt a new airworthiness directive (AD) for certain McDonnell Douglas Corporation... [Amended] 2. The FAA amends Sec. 39.13 by adding the following new AD: McDonnell Douglas Corporation...
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2010-12-07
... Airworthiness Directives; McDonnell Douglas Corporation Model DC- 9-30, DC-9-40, and DC-9-50 Series Airplanes...: We are adopting a new airworthiness directive (AD) for the McDonnell Douglas Corporation airplanes... to include an airworthiness directive (AD) that would apply to certain McDonnell Douglas Model DC-9...
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The adnAB Locus, Encoding a Putative Helicase-Nuclease Activity, Is Essential in Streptomyces
Zhang, Lingli; Nguyen, Hoang Chuong; Chipot, Ludovic; Piotrowski, Emilie; Bertrand, Claire
2014-01-01
Homologous recombination is a crucial mechanism that repairs a wide range of DNA lesions, including the most deleterious ones, double-strand breaks (DSBs). This multistep process is initiated by the resection of the broken DNA ends by a multisubunit helicase-nuclease complex exemplified by Escherichia coli RecBCD, Bacillus subtilis AddAB, and newly discovered Mycobacterium tuberculosis AdnAB. Here we show that in Streptomyces, neither recBCD nor addAB homologues could be detected. The only putative helicase-nuclease-encoding genes identified were homologous to M. tuberculosis adnAB genes. These genes are conserved as a single copy in all sequenced genomes of Streptomyces. The disruption of adnAB in Streptomyces ambofaciens and Streptomyces coelicolor could not be achieved unless an ectopic copy was provided, indicating that adnAB is essential for growth. Both adnA and adnB genes were shown to be inducible in response to DNA damage (mitomycin C) and to be independently transcribed. Introduction of S. ambofaciens adnAB genes in an E. coli recB mutant restored viability and resistance to UV light, suggesting that Streptomyces AdnAB could be a functional homologue of RecBCD and be involved in DNA damage resistance. PMID:24837284
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2010-06-18
...-0549; Directorate Identifier 2010-NM-109-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... [Amended] 2. The FAA amends Sec. 39.13 by adding the following new AD: McDonnell Douglas Corporation... comments by August 2, 2010. Affected ADs (b) None. Applicability (c) This AD applies to McDonnell Douglas...
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Up through the Ranks at McDonnell Douglas.
Settle, Mary
1989-01-01
Raher than bemoan the lack of leadership potential among younger employees, McDonnell Douglas Corporation has embarked on a comprehensive strategy of on-the-job development for staff members at all levels of the organization. Three types of rotational training are being used to address corporate, functional, and intracompany needs. (Author)
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Directory of Open Access Journals (Sweden)
Asad Rahman
2018-03-01
Full Text Available Ammonium Dinitramide (ADN in its generic form has a long needle shaped structure, which hinders higher solid loading. Therefore, it is of utmost importance to optimize its crystal morphology into octagonal shapes. Moreover, the low critical humidity level of ADN renders it unusable in a humid climate. Hence, encapsulation with a hydrophobic polymer is necessary. In the present work, ADN was synthesized by nitration of potassium sulfamate with mixed acid nitration. The product was then mixed with toluene, graphene, citryl ammonium butyl, Cab-o-sil, and coating polymer (Polystyrene or HTPB and treated with ultrasound to obtain semi-spherical ADN-coated particles. The method offers a reduction in operating temperature and elimination of ADN melting in the shape-altering process. In addition, the ADN product has a similar particle size and thermal stability compared to those in a conventional ADN melt-prilling method. The ADN product investigated under SEM confirms the particle morphological change from long needles into semi-spherical shapes. The particle size obtained, in the micrometer range, is ideal for higher theoretical maximum density. Furthermore, the ultrasound-treated ADN particles show significant reduction in moisture absorption, from 68% to 16% at 65% relative humidity. The DSC result shows no degradation of thermal stability of the coated particles.
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2010-10-14
... Airworthiness Directives; McDonnell Douglas Corporation Model DC- 10-10, DC-10-10F, DC-10-30, DC-10-30F (KDC-10... following new airworthiness directive (AD): 2010-21-13 McDonnell Douglas Corporation: Amendment 39-16473... November 18, 2010. Affected ADs (b) None. Applicability (c) This AD applies to McDonnell Douglas...
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2010-11-05
...-1044; Directorate Identifier 2010-NM-033-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas..., 2007) and adding the following new AD: McDonnell Douglas Corporation: Docket No. FAA-2010-1044.... Applicability (c) This AD applies to all McDonnell Douglas Corporation Model DC-10-10, DC-10-10F, DC-10-15, DC...
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2010-10-01
... Airworthiness Directives; McDonnell Douglas Corporation Model DC- 10-10, DC-10-10F, DC-10-15, DC-10-30, DC-10... adding the following new AD: 2010-20-14 McDonnell Douglas Corporation: Amendment 39-16449. Docket No. FAA... the airplanes identified in paragraphs (c)(1) and (c)(2) of this AD. (1) McDonnell Douglas Corporation...
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2010-07-07
...-0672; Directorate Identifier 2010-NM-047-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas...: McDonnell Douglas Corporation: Docket No. FAA-2010-0672; Directorate Identifier 2010-NM-047-AD. Comments Due... applies to McDonnell Douglas Corporation Model DC- 10-10, DC-10-10F, DC-10-30, DC-10-30F (KDC-10), DC-10...
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Inhibidor de la enzima uracilo ADN glicosilasa y usos del mismo
Serrano-Heras, Gemma; Bravo, Alicia; Salas, Margarita
2005-01-01
Inhibidor de la enzima uracilo adn glicosilasa y usos del mismo Esta invención se refiere a una proteína que inhibe la enzima uracilo ADN glicosilasa (UDG) vírica, para su uso como un agente terapéutico, en particular como un agente antiví
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2010-02-08
...-0032; Directorate Identifier 2009-NM-213-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas...: McDonnell Douglas Corporation: Docket No. FAA-2010-0032; Directorate Identifier 2009-NM-213-AD. Comments Due... applies to McDonnell Douglas Corporation Model DC- 10-10, DC-10-10F, DC-10-15, DC-10-30, DC-10-30F (KC-10A...
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2010-10-07
... Airworthiness Directives; McDonnell Douglas Corporation Model DC- 8-31, DC-8-32, DC-8-33, DC-8-41, DC-8-42, and... to all of the McDonnell Douglas Corporation airplanes identified above. The existing AD currently... the following new airworthiness directive (AD): 2010-21-03 McDonnell Douglas Corporation: Amendment 39...
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2010-01-19
...-0043; Directorate Identifier 2009-NM-128-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... directive (AD) for certain McDonnell Douglas Model DC-10-10, DC-10-10F, and MD-10-10F airplanes. This... adding the following new AD: McDonnell Douglas Corporation: Docket No. FAA-2010-0043; Directorate...
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Krause, Horst; Schlechtriem, Stefan; Weiser, Volker; Schaller, Uwe; Hürttlen, Jürgen
2016-01-01
Es wird ein Gasgenerator-Treibstoff vorgeschlagen, welcher einen monergolen Treibstoff auf der Basis von Ammoniumdinitramid (ADN) und wenigstens ein Lösungsmittel enthält, wobei der Gasgenerator-Treibstoff wenigstens 65 Mass.-% ADN und höchstens 5 Mass.-% Wasser, jeweils bezogen auf die Mischung aus ADN und Lösungsmittel, enthält, und wobei wenigstens ein Lösungsmittel von Ammoniak (NH3) gebildet ist. Der Gasgenerator-Treibstoff ist vorzugsweise im Wesentlichen wasserfrei und enthält keine we...
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2010-05-04
... Airworthiness Directives; McDonnell Douglas Corporation Model DC- 10-10, DC-10-10F, DC-10-15, DC-10-30, DC-10... amends Sec. 39.13 by adding the following new AD: 2010-09-12 McDonnell Douglas Corporation: Amendment 39... to McDonnell Douglas Corporation Model DC- 10-10, DC-10-10F, DC-10-15, DC-10-30, DC-10-30F (KC-10A...
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2010-06-23
... Airworthiness Directives; McDonnell Douglas Corporation Model DC- 10-10, DC-10-10F, and MD-10-10F Airplanes... certain McDonnell Douglas Model DC-10-10, DC-10-10F, and MD-10-10F airplanes. That NPRM was published in... amends Sec. 39.13 by adding the following new AD: 2010-13-06 McDonnell Douglas Corporation: Amendment 39...
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2010-10-05
... Airworthiness Directives; McDonnell Douglas Corporation Model DC- 10-30, DC-10-30F, DC-10-30F (KC-10A and KDC-10...-13 McDonnell Douglas Corporation: Amendment 39-16448; Docket No. FAA-2010-0553; Directorate.... Applicability (c) This AD applies to McDonnell Douglas Corporation Model DC- 10-30, DC-10-30F, DC-10-30F (KC-10A...
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Davis, Simon
2017-10-23
In 1927 Michael McDonnell, a diasporic Irish Catholic, was appointed Mandatory Palestine's Chief Justice, being directed to institute firm British-style legal-judicial foundations for future self-governance. This entailed common, equal status for Arab and Jewish Palestinians, implicitly de-privileging the Jewish National Home. McDonnell was resisted in this by the British Mandate's Anglo-Jewish, pro-Zionist Attorney General, Norman Bentwich. McDonnell prevailed but only at the cost of being characterized lastingly as a pro-Arab, Catholic anti-Semite. McDonnell's continuing defence of a supreme, independent judiciary antagonized the Palestine Executive of High Commissioner Arthur Wauchope, who tried to co-opt rather than subordinate Zionist interests. Consequent frictions culminated in 1936 with McDonnell adjudicating against supra-legal British repression of Palestine's great Arab rebellion. For this he was dismissed and ostracized, subsequently publishing critiques of British policy in fringe right-wing organs. Yet McDonnell professed explicitly non-racist views, reflecting a liberal-minded, constitutional Irish nationalist equation of Palestine with Ireland, seeing comparable settler-colonial abuses and native distress as remediable only by transcendentally impartial justice. Britain reneging on these principles led McDonnell, like those Irish imperial servants noted in India, to identify with colonial subjects against colonialism. His case is one of empire as a system of domination being challenged from within, although his removal foreshadowed emerging imperial counter-insurgency's tendency not only to repress subject populations but deny civil-progressive alternatives for managing post-colonial transition. © The Author [2017]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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Said another way. Is the ADN graduate prepared to practice in community settings?
Percoco, T A
1998-01-01
The downsizing and closing of acute care facilities and the movement to community-based healthcare services are decreasing the need for RNs in acute care facilities. In the past, the associate-degree nurse (ADN) has filled the majority of positions in acute care. With the trend to provide health services in community setting, will the ADN be prepared for positions in community facilities? ADN educators must reevaluate how they are educating students for practice. The author reviews the 1995 recommendations from the Pew Health Professions Commission and relevant current directives from the National League for Nursing.
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Fusion energy development at McDonnell Douglas: why and how
International Nuclear Information System (INIS)
Ard, W.B.
1985-01-01
The McDonnell Douglas Astronautics Company started a development program in fusion energy in 1974. This paper discusses the rationale for an industrial program in fusion energy and gives a brief account of the major activities that the company has been involved in during the course of this effort
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Fraga Nodarse, Jorge; Rodríguez, Jinnay; Fuentes, Omar; Castex, Mayda; Fernández-Calienes, Aymé
2004-01-01
Se evaluó la aplicabilidad de 5 protocolos útiles para la extracción del ADN genómico de Triatomíneos, y se describió el método del acetato de potasio modificado, como un método con el que se obtiene un alto rendimiento y pureza del ADN en el menor tiempo y costo, para su utilización como molde en la técnica de ADN polimórfico amplificado al azar (RAPD [la cual es un método simple para detectar el polimorfismo genético del ADN]) y probablemente en otras técnicas moleculares basadas en la ampl...
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AISLAMIENTO DE ADN GENÓMICO DE Myrciaria dubia (HBK “CAMU CAMU” APROPIADO PARA ANÁLISIS MOLECULARES
Directory of Open Access Journals (Sweden)
Juan Castro Gómez
2012-06-01
Full Text Available Myrciaria dubia “camu-camu”, una especie nativa de la Amazonía que produce frutos con alto contenido de vitamina C y otras sustancias importantes. Sin embargo, los estudios moleculares de esta planta son escasos, por falta de un protocolo reproducible para purificar sus ácidos nucléicos. El objetivo de este trabajo fue establecer un protocolo para aislar el ADN genómico a partir de hojas de M. dubia, apropiado para análisis moleculares. El ADN se purificó con un protocolo modificado, la calidad y cantidad se estimó por espectrofotometría y electroforesis en gel de agarosa. Adicionalmente, la calidad se evaluó mediante RAPD. El ratio de calidad (A260/A280 promedio del ADN fue 1.9±0.1 y el espectro de absorción UV/Vis presentó un único pico de máxima absorbancia a 260nm. Mediante electroforesis el ADN fue íntegro y sin ARN. También, la síntesis de amplicones RAPD nos sugiere ausencia de inhibidores para polimerasas. La concentración promedio del ADN fue 99±33 ng/ml y el rendimiento promedio fue 237±80 mg ADN/g hoja. En conclusión, se ha establecido un protocolo de aislamiento de ADN genómico a partir de hojas de Myrciaria dubia “camu camu”, caracterizado por permitirnos obtener ADN de alta calidad y cantidad suficiente para análisis moleculares como el RAPD.
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Mechanism and kinetics for ammonium dinitramide (ADN) sublimation: a first-principles study.
Zhu, R S; Chen, Hui-Lung; Lin, M C
2012-11-08
The mechanism for sublimation of NH(4)N(NO(2))(2) (ADN) has been investigated quantum-mechanically with generalized gradient approximation plane-wave density functional theory calculations; the solid surface is represented by a slab model and the periodic boundary conditions are applied. The calculated lattice constants for the bulk ADN, which were found to consist of NH(4)(+)[ON(O)NNO(2)](-) units, instead of NH(4)(+)[N(NO(2))(2)](-), agree quite well with experimental values. Results show that three steps are involved in the sublimation/decomposition of ADN. The first step is the relaxation of the surface layer with 1.6 kcal/mol energy per NH(4)ON(O)NNO(2) unit; the second step is the sublimation of the surface layer to form a molecular [NH(3)]-[HON(O)NNO(2)] complex with a 29.4 kcal/mol sublimation energy, consistent with the experimental observation of Korobeinichev et al. (10) The last step is the dissociation of the [H(3)N]-[HON(O)NNO(2)] complex to give NH(3) and HON(O)NNO(2) with the dissociation energy of 13.9 kcal/mol. Direct formation of NO(2) (g) from solid ADN costs a much higher energy, 58.3 kcal/mol. Our calculated total sublimation enthalpy for ADN(s) → NH(3)(g) + HON(O)NNO(2)) (g), 44.9 kcal/mol via three steps, is in good agreement with the value, 42.1 kcal/mol predicted for the one-step sublimation process in this work and the value 44.0 kcal/mol computed by Politzer et al. (11) using experimental thermochemical data. The sublimation rate constant for the rate-controlling step 2 can be represented as k(sub) = 2.18 × 10(12) exp (-30.5 kcal/mol/RT) s(-1), which agrees well with available experimental data within the temperature range studied. The high pressure limit decomposition rate constant for the molecular complex H(3)N···HON(O)NNO(2) can be expressed by k(dec) = 3.18 × 10(13) exp (-15.09 kcal/mol/RT) s(-1). In addition, water molecules were found to increase the sublimation enthalpy of ADN, contrary to that found in the ammonium
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2010-12-30
...-1206; Directorate Identifier 2009-NM-216-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... amends Sec. 39.13 by adding the following new AD: McDonnell Douglas Corporation: Docket No. FAA-2010-1206.... [[Page 82335
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Extracción del ADN de Fusarium Oxysporum f.sp. Dianthi
Directory of Open Access Journals (Sweden)
Sixta T. Martínez
2010-07-01
Full Text Available Se estudia la utílización de dos métodos para la extracción del ADN del Fusarium o.xy.sporum f.sp. Dianthi. En los dos métodos la pared del hongo se rompió con nitrógeno líquido, uno de ellos empleó como solución extractora bromuro de cetiltrimetil amonio (BCTA y el otro una solución de sacarosa con altas concentraciones de protcasa y EDTA. Para la desproteinización ambos métodos utilizaron soluciones de fcnol-clorofonno y enzimas proteolítícas. El ADN obtenido se digirió con enzimas de restricción EcoRI y Hindlll. Se corroboró que cl ADN estaba libre de los contaminantes más frecuentes en hongos, como proteínas y carbohidratos por medio de ultracentrifugación en cloruro de cesio (CsCI. La extracción con BCTA presentó los mejores rendimientos.
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BIOSENSORES DE ADN BASADOS EN NANOTUBOS DE CARBONO MODIFICADOS QUIMICAMENTE
CAÑETE ROSALES, PAULINA ALEJANDRA; CAÑETE ROSALES, PAULINA ALEJANDRA
2011-01-01
Muchos de los desórdenes genéticos conocidos en la actualidad son provocados por cambios en el ADN, ya sea heredados o producidos por daño del material genético, por lo que la detección de estas secuencias específicas y/o su daño es muy importante. En la actualidad se han descrito numerosos métodos para detectar ADN, siendo los biosensores electroquímicos o genosensores los que ofrecen una alternativa de detección continua, rápida, sensible y selectiva. En esta Tesis s...
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INFERTILIDAD MASCULINA Y FRAGMENTACIÓN DEL ADN ESPERMÁTICO: UN PROBLEMA ACTUAL
Directory of Open Access Journals (Sweden)
Gabriela Alejandra Quintero\\u2013Vásquez
2015-01-01
Full Text Available El ADN del espermatozoide aporta la mitad del material genético a la descendencia, en la actualidad los parámetros obtenidos a través de un seminograma no dan una información completa sobre el potencial fecundante del semen y la capacidad de dar lugar a un embrión sano y un embarazo evolutivo. Es por ésto que ha aumentado el interés en desarrollar técnicas encaminadas a evaluar la fragmentación del ADN espermático, ya que en cualquier etapa del proceso de la espermatogénesis se puede producir un daño, siendo éste un fenómeno multifactorial y no del todo delimitado. Actualmente la infertilidad es un problema global que va en aumento y se ha demostrado que la calidad del ADN del espermatozoide puede afectar la fecundación; es por ello que la evaluación de la integridad del ADN, además del estudio de los parámetros seminales, puede aportar información adicional acerca de la calidad del espermatozoide, y ser de gran ayuda para identificar las causas de la infertilidad masculina y así orientar de mejor manera a las parejas.
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2010-12-23
...-1203; Directorate Identifier 2010-NM-168-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... amends Sec. 39.13 by adding the following new airworthiness directive (AD): McDonnell Douglas Corporation... Douglas Corporation Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87) and MD-88...
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Pontius, H.; Dörich, M.; Bohn, M.A.
2003-01-01
The determination of the adiabatic self heating, for example by an Accelerating Rate Calorimeter (ARC™), is a method to characterize the thermal decomposition of energetic materials. To study the decomposition mechanisms occurring during the self heating a procedure was developed to take out the decomposition gases of the ARC system. The suitability of the device was tested with the oxidizer ammonium dinitramide (ADN). The main reaction products of ADN, nitrate, nitrogen and dinitrogen monoxi...
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2010-04-21
...-0384; Directorate Identifier 2010-NM-003-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... Douglas Corporation: Docket No. FAA-2010-0384; Directorate Identifier 2010-NM-003-AD. Comments Due Date (a... the airplanes identified in paragraphs (c)(1) and (c)(2) of this AD. (1) McDonnell Douglas Corporation...
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The Oklahoma PN/ADN Articulation Project Report.
Oklahoma State Regents for Higher Education, Oklahoma City.
In response to a critical nursing shortage in the state of Oklahoma, the Oklahoma Practical Nursing (PN)/Associate Degree Nursing (ADN) Articulation Project Coordinating Committee was formed in spring 1990 to develop a proposal for program articulation. A curriculum matrix was designed and adopted for use by five regional subcommittees which…
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Dumont, Ariane
Il a ete demontre que les electrons de basse energie (EBE) peuvent induire des cassures simple brin (CSB) a l'ADN, via la formation d'anions transitoires qui decroissent par attachement dissociatif, ou dans d'autres etats electroniques dissociatifs menant a la fragmentation. Afin d'effectuer une etude complete des effets des electrons de basse energie sur la matiere biologique, il est necessaire de comprendre leur mecanismes d'interaction non seulement avec l'ADN, mais avec les constituants de son environnement. Les histones sont une composante importante de l'environnement moleculaire de l'ADN. Leur charge positive leur permet de s'associer aux groupements phosphate anionique de l'ADN. Le role principal de ces proteines basiques consiste a organiser l'ADN et l'empaqueter afin de former la chromatine. Les cations sont une autre composante importante de la cellule; ils jouent un role dans la stabilisation de la conformation B de l'ADN in vitro par leurs interactions avec les petits et grands sillons de l'ADN, ainsi qu'avec le groupement phosphate charge negativement. Avec les histones, ils participent egalement a la compaction de l'ADN pour former la chromatine. Cette etude a pour but de comprendre comment la presence d'ions organiques (sous forme de Tris et d'EDTA) a proximite de l'ADN modifie le rendement de cassures simple brin induit par les electrons de basse energie. Le Tris et l'EDTA ont-ete choisis comme objet d'etude, puisqu'en solution, ils forment le tampon standard pour solubiliser l'ADN dans les experiences in vitro (10mM Tris, 1mM EDTA). De plus, la molecule Tris possede un groupement amine alors que l'EDTA possede 4 groupements carboxyliques. Ensembles, ils peuvent se comporter comme un modele simple pour les acides amines. Le ratio molaire de 10 :1 de Tris par rapport a l'EDTA a pour but d'imiter le comportement des histones qui sont riches en arginine et lysine, acides amines possedant un groupement amine charge positivement additionnel. Des films d'ADN
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Extracción del ADN de Fusarium Oxysporum f.sp. Dianthi
Sixta T. Martínez; Carlos Y. Soto
2010-01-01
Se estudia la utílización de dos métodos para la extracción del ADN del Fusarium o.xy.sporum f.sp. Dianthi. En los dos métodos la pared del hongo se rompió con nitrógeno líquido, uno de ellos empleó como solución extractora bromuro de cetiltrimetil amonio (BCTA) y el otro una solución de sacarosa con altas concentraciones de protcasa y EDTA. Para la desproteinización ambos métodos utilizaron soluciones de fcnol-clorofonno y enzimas proteolítícas. El ADN obtenido se digirió con enzimas d...
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LVN to ADN: Innovative, Non-Traditional Learning Project.
Austin Community Coll., TX.
This document contains the curriculum for the first nursing course in the Licensed Vocational Nurse Mobility Track Project. The project is designed to provide selected Licensed Vocational Nurses (LVNs) the opportunity to complete the nursing course requirements for an Associate of Applied Science Degree in Nursing (ADN) in three semesters of…
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Millán Elías, Cinthia Raquel
2013-01-01
Las actividades relacionadas con el ADN como la transcripción, replicación, recombinación y reparación implican cambios en la estructura del ADN y en la organización de la cromatina. Estos cambios estructurales dependen de su interacción con proteínas. Las proteínas HMGA1 (High Mobility Group A1) son miembros de una superfamilia de proteínas de baja masa molecular, se encuentran en el núcleo de las células y modifican la conformación espacial del ADN. Actúan como factores de transcri...
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Ensayos cristalográficos de complejos de ADN con proteínas HMG-box y fármacos
Gomez Jimenez, Fabiola Alejandra
2016-01-01
Las HMGB son proteínas nucleares que presentan el motivo “HMG-box”, con el que se unen al surco estrecho del ADN. Producen cambios estructurales en el mismo y están implicadas en diferentes enfermedades por lo que el estudio estructural de dichas proteínas unidas a ADN es de importancia en el desarrollo de estrategias terapéuticas. Por otra parte, los compuestos derivados de difenilo bisimidazolinio también se unen al surco estrecho del ADN, específicamente en zonas ricas en AT...
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Extracción y purificación de ADN de pelo a pH muy ácido
Hidalgo, Pedro C.; Ackermann, Elizabeth; Figueiro, Gonzalo; Sans, Mónica
2009-01-01
El aislamiento y purificación de ADN es el paso inicial en los protocolos de PCR. Uno de los problemas que se presentan es la dificultad en la obtención de la muestra; los métodos basados en muestras sanguíneas, si bien permiten la obtención de una gran cantidad de ADN, tienen como inconveniente la dificultad de obtención de la muestra así como la conservación de éstas previa a la extracción de ADN. Es por eso que se buscó un nuevo método que se basara en muestras fácilmente obtenibles inclus...
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Directory of Open Access Journals (Sweden)
Nadia Guadalupe Sánchez-Coello
2012-01-01
Full Text Available La mayoría de las cícadas contienen altas concentraciones de aceites esenciales, flavonoides, polifenoles y polisacáridos que interfieren en la extracción de ADN, causando productos de amplificación errados o inhibiendo la PCR. La optimización del aislamiento del ADN y el empleo de iniciadores de secuencias intergénicas repetidas simples (ISSRs se investigaron en Ceratozamia mexicana Brongn., una cícada mexicana en peligro de extinción. El ADN obtenido de tejido foliar fresco, con un amortiguador modificado de cetil trimetil amonio, nos permitió obtener un ADN de buena calidad, sin pigmentos coloridos o contaminantes. La modificación al protocolo de extracción de ADN, basado en CTAB, fue un prelavado por 1 h, del tejido foliar, con una solución de 0.7 M de NaCl, para facilitar la lisis celular. El ADN extraído exitosamente se amplificó por PCR, usando seis iniciadores arbitrarios ISSR. Se observaron productos de amplificación reproducibles en todas las reacciones de PCR. Nuestros resultados muestran que la implementación mejora significativamente la calidad del ADN obtenido, usando una concentración baja de iniciadores (25 pM. Se detectaron 23 bandas fuertes, nueve de las cuales fueron polimórficas. Los resultados indican que el protocolo de optimización del aislamiento del ADN y en el sistema de PCR es viable para futuros trabajos en esta especie. Este trabajo es el primer protocolo de extracción de ADN y de ISSR reportado para esta especie ornamental en peligro de extinción.
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Chen, Jun; Li, Guoxiu; Zhang, Tao; Wang, Meng; Yu, Yusong
2016-12-01
Low toxicity ammonium dinitramide (ADN)-based aerospace propulsion systems currently show promise with regard to applications such as controlling satellite attitude. In the present work, the decomposition and combustion processes of an ADN-based monopropellant thruster were systematically studied, using a thermally stable catalyst to promote the decomposition reaction. The performance of the ADN propulsion system was investigated using a ground test system under vacuum, and the physical properties of the ADN-based propellant were also examined. Using this system, the effects of the preheating temperature and feed pressure on the combustion characteristics and thruster performance during steady state operation were observed. The results indicate that the propellant and catalyst employed during this work, as well as the design and manufacture of the thruster, met performance requirements. Moreover, the 1 N ADN thruster generated a specific impulse of 223 s, demonstrating the efficacy of the new catalyst. The thruster operational parameters (specifically, the preheating temperature and feed pressure) were found to have a significant effect on the decomposition and combustion processes within the thruster, and the performance of the thruster was demonstrated to improve at higher feed pressures and elevated preheating temperatures. A lower temperature of 140 °C was determined to activate the catalytic decomposition and combustion processes more effectively compared with the results obtained using other conditions. The data obtained in this study should be beneficial to future systematic and in-depth investigations of the combustion mechanism and characteristics within an ADN thruster.
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Jobin-Robitaille, Olivier
2005-01-01
Tableau d'honneur de la Faculté des études supérieurs et postdoctorales, 2005-2006 La cellule dispose de plusieurs mécanismes de réparation, nécessitant tous l'accès à l'ADN, afin de prévenir les perturbations occasionnées par l'instabilité génomique. La structure des chromosomes eucaryotes (chromatine) forme une barrière physique empêchant l'accessibilité à l'ADN et ainsi les processus biologiques nucléaires tels la transcription, réplication, recombinaison et réparation des dommages de ...
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Comparación de dos protocolos de extracción de ADN de Trypanosoma cruzi cultivados en medio axénico
Directory of Open Access Journals (Sweden)
Mariela López
Full Text Available Objetivos. Comparar dos protocolos de extracción de ADN de Trypanosoma cruzi para su uso en la amplificación de ADN de minicírculos de kinetoplasto (ADNk mediante la técnica de Reacción en Cadena de Polimerasa (PCR. Materiales y métodos. Se cultivaron epimastigotas de T. cruzi en condiciones exénicas obteniéndose masas entre 1,5 hasta 100 x 10(6 parásitos. A partir de estas se procedió a la extracción de ADN mediante dos protocolos: extracción con solventes orgánicos (fenol/cloroformo, y empleo de resina (Chelex®100, a partir de los diferentes sedimentos parasitarios. La concentración y pureza del ADN se determinó por espectrofotometría y la integridad se evaluó mediante electroforesis en geles de agarosa. Se realizó el análisis de varianza y comparaciones de medias mediante la prueba de Tukey, utilizando el software Statistix 8.0. Resultados. Se realizaron diez extracciones de ADN de cada una de las diferentes cantidades de parásitos sedimentados. En la extracción de ADN con la resina Chelex®100 se obtuvo mayor rendimiento, pero menor pureza e integridad respecto a la extracción con solventes orgánicos. Sin embargo, permitió la amplificación del producto de 330 pb de ADNk de T. cruzi. Conclusiones. Aun cuando la técnica de Chelex®100 proporcionó menor pureza e integridad del ADN, permitió la amplificación con éxito de ADNk por PCR, evitando el uso de técnicas laboriosas y solventes orgánicos tóxicos
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Experimental investigation of atomization characteristics of swirling spray by ADN gelled propellant
Guan, Hao-Sen; Li, Guo-Xiu; Zhang, Nai-Yuan
2018-03-01
Due to the current global energy shortage and increasingly serious environmental issues, green propellants are attracting more attention. In particular, the ammonium dinitramide (ADN)-based monopropellant thruster is gaining world-wide attention as a green, non-polluting and high specific impulse propellant. Gel propellants combine the advantages of liquid and solid propellants, and are becoming popular in the field of spaceflight. In this paper, a swirling atomization experimental study was carried out using an ADN aqueous gel propellant under different injection pressures. A high-speed camera and a Malvern laser particle size analyzer were used to study the spray process. The flow coefficient, cone angle of swirl atomizing spray, breakup length of spray membrane, and droplet size distribution were analyzed. Furthermore, the effects of different injection pressures on the swirling atomization characteristics were studied.
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Yang, Wei; Zhao, Jin; Wang, Yake; Xu, Haiwei; Wu, Zhenwei; Hu, Yangyang; Jiang, Kunkun; Shen, Pengpeng; Ma, Cuiyun; Guan, Zhenzhen; Zhang, Yan; Ma, Jiahui; Shang, Ning; Yan, Guangming; Wang, Zhenji; Dai, Guifu
2017-07-15
It is well known that liver cancer is a highly aggressive malignancy with poor prognosis. Andrographolide (AD), a major bioactive component of Andrographis paniculata (Burm. F.), is a potential anti-cancer pharmacophore and the synthesis of AD derivatives with better cytotoxicity to cancer cells has attracted considerable attentions. In the present study, we evaluated the in vivo inhibitory effects of ADN-9, a 15-benzylidene substituted derivative of AD, on the growth and metastasis of murine hepatoma H22 using an orthotopic xenograft model and a subcutaneous xenograft model, and we further studied the anti-angiogenic action and the related mechanisms of ADN-9 in vivo and in vitro. Importantly, ADN-9 remarkably suppressed the growth and metastasis of both orthotopic and subcutaneous xenograft tumors, and the serum AFP level in orthotopic hepatoma-bearing mice treated with 100mg/kg ADN-9 (ig.) was decreased to the normal level. We also found that ADN-9 showed stronger abilities than AD in shrinking tumors, suppressing the invasion and metastasis of H22 cells, decreasing the MVD and promoting tumor cell apoptosis in subcutaneous xenograft of mice. Additionally, ADN-9 exhibited stronger inhibitory activity than AD against the migration and VEGF-induced capillary-like tube formation in HUVECs, which was further proved to be associated with attenuating VEGF/VEGFR2/AKT signaling pathway. The present research provides the first evidence that a 15-substituted AD derivative is more promising than the parent compound in therapeutic treatment of liver cancer. Copyright © 2017 Elsevier Inc. All rights reserved.
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DIAZ PEREZ, NELSON FELIX
2013-01-01
Se realizó un proyecto de I+D a través del cual se identificaron, caracterizaron y seleccionaron marcadores de ADN del tipo RAPD-SCAR, RFLP, SSR, ADNmt e ITS, en el genoma de especies de salmones, truchas, abalones y mitílidos. Los marcadores fueron seleccionados en vistas a generar servicios con marcadores de ADN y asesoría genética para identificar organismos, detectar asociación con características específicas de importancia productiva, y así contribuir a su selección gen...
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International Nuclear Information System (INIS)
Zhang, Tao; Li, Guoxiu; Yu, Yusong; Sun, Zuoyu; Wang, Meng; Chen, Jun
2014-01-01
Highlights: • Decomposition and combustion process of ADN-based thruster are studied. • Distribution of droplets is obtained during the process of spray hit on wire mesh. • Two temperature models are adopted to describe the heat transfer in porous media. • The influences brought by different mass flux and porosity are studied. - Abstract: Ammonium dinitramide (ADN) monopropellant is currently the most promising among all ‘green propellants’. In this paper, the decomposition and combustion process of liquid ADN-based ternary mixtures for propulsion are numerically studied. The R–R distribution model is used to study the initial boundary conditions of droplet distribution resulting from spray hit on a wire mesh based on PDA experiment. To simulate the heat-transfer characteristics between the gas–solid phases, a two-temperature porous medium model in a catalytic bed is used. An 11-species and 7-reactions chemistry model is used to study the catalytic and combustion processes. The final distribution of temperature, pressure, and other kinds of material component concentrations are obtained using the ADN thruster. The results of simulation conducted in the present study are well agree with previous experimental data, and the demonstration of the ADN thruster confirms that a good steady-state operation is achieved. The effects of spray inlet mass flux and porosity on monopropellant thruster performance are analyzed. The numerical results further show that a larger inlet mass flux results in better thruster performance and a catalytic bed porosity value of 0.5 can exhibit the best thruster performance. These findings can serve as a key reference for designing and testing non-toxic aerospace monopropellant thrusters
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Optimización de un protocolo de extracción de ADN genómico para Pinus tecunumanii
Directory of Open Access Journals (Sweden)
David A. Cerda-Granados
2013-05-01
Full Text Available Se optimizó un protocolo para la extracción de ADN genómico de Pinus tecunumanii basado en el método de extracción de Doyle y Doyle (1990. Se probaron los megagametofitos de las semillas de árboles deP. tecunumanii muestreados en cinco poblaciones naturales de Nicaragua. El método consta de maceración del tejido en tubos Eppendorf, una extracción con bromuro trimetil amonio de cetilo (CTABempleando altas concentraciones de sales, proteinasa K, extracciones sucesivas con cloroformo-alcohol isoamílico y un tratamiento con ARNasa A. El rendimiento fue aproximadamente 13μg de ADN por 58.7 mg de tejido inicial fresco. El ADNgenómico obtenido por este método fue apropiado para ser usado en reaccionesRAPD (ADN polimórfico amplificado al azar
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Análisis del ADN mitocondrial de dos muestras del yacimiento paleolítico de El Pirulejo.
Fernández Domínguez, Eva; Prats, E.; Arroyo-Pardo, Eduardo; Martínez Pérez-Pérez, Alejandro; Turbón, Daniel; Cortés Sánchez, Miguel
2008-01-01
En la presente publicación se presentan los resultados del análisis del ADN mitocondrial (ADNmt) de dos individuos del nivel magdaleniense de El Pirulejo (Córdoba) (Asquerino et al., 1991). Las secuencias obtenidas se encuadran dentro de la variabilidad genética del hombre moderno actual, sin presentar similitud alguna con las secuencias de ADN mitocondrial de neandertal publicadas hasta la fecha. La distribución actual de las variantes mitocondriales encontradas en las dos muestras de El Pir...
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ADN – The new oxidizer around the corner for an environmentally friendly smokeless propellant
Directory of Open Access Journals (Sweden)
Márcio Y. Nagamachi
2009-06-01
Full Text Available The search for a smokeless propellant has encouraged scientists and engineers to look for a chlorine-free oxidizer as a substitute for AP (ammonium perchlorate. Endeavors seemed to come to an end when ADN (ammonium dinitramide appeared in the West in the early 1990s. Although some drawbacks soon became apparent by that time, the foremost obstacle for its use in rocket-motors came from the patent originally applied for in the United States in 1990. Furthermore, environmental concerns have also increased during these two decades. Ammonium perchlorate is believed to cause thyroid cancer by contaminating soil and water. In addition, AP produces hydrogen chloride during burning which can cause acid rain and ozone layer depletion. Unlike AP, ADN stands for both smokeless and green propellant. Since then, much progress has been made in its development in synthesis, re-shaping, microencapsulation and solid propellant. The high solubility of ADN in water has also allowed its application as liquid monopropellant. Tests have revealed Isp (specific impulse superior to that normally observed with hydrazine, one of the most harmful and hazardous liquid propellants. With constraints of use, along with the patent near to expiry, scientists and engineers are rushing to complete developments and patents until then.
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Evolucion humana y el ADN mitocondrial (II)
Amat Olazabal, Hernan
2014-01-01
En el presente ensayo nos proponemos mostrar un recorrido por la historia de nuestros antepasados desde que nos separamaos del linaje de los chimpancés, hace 5 a 6 millones hasta la aparición del Homo sapiens, resultado de una serie de cambios evolutivos trascendentales. Tratamos de presentar los estudios más recientes acerca de la evolución humana y el ADN mt, que evidencia que todos procedemos desde África, y en un época pródiga en descubrimientos paleontólógicos y arqueológicos y de debate...
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Kołaczkowski, M; Mierzejewski, P; Bieńkowski, P; Wesołowska, A; Newman-Tancredi, A
2014-02-01
Many dementia patients exhibit behavioural and psychological symptoms (BPSD) that include psychosis, aggressivity, depression and anxiety. Antipsychotic drugs are frequently prescribed but fail to significantly attenuate mood deficits, may interfere with cognitive function and are associated with motor and cardiac side effects, which are problematic in elderly patients. A need therefore exists for drugs that are better suited for the treatment of BPSD. We used in vitro cellular and in vivo behavioural tests to characterize ADN-1184, a novel arylsulfonamide ligand with potential utility for treatment of BPSD. ADN-1184 exhibits substantial 5-HT6 /5-HT7 /5-HT2A /D2 receptor affinity and antagonist properties in vitro. In tests of antipsychotic-like activity, it reversed MK-801-induced hyperactivity and stereotypies and inhibited conditioned avoidance response (MED = 3 mg·kg(-1) i.p.). Remarkably, ADN-1184 also reduced immobility time in the forced swim test at low doses (0.3 and 1 mg·kg(-1) i.p.; higher doses were not significantly active). Notably, up to 30 mg·kg(-1) ADN-1184 did not impair memory performance in the passive avoidance test or elicit significant catalepsy and only modestly inhibited spontaneous locomotor activity (MED = 30 mg·kg(-1) i.p.). ADN-1184 combines antipsychotic-like with antidepressant-like properties without interfering with memory function or locomotion. This profile is better than that of commonly used atypical antipsychotics tested under the same conditions and suggests that it is feasible to identify drugs that improve BPSD, without exacerbating cognitive deficit or movement impairment, which are of particular concern in patients with dementia. © 2013 The British Pharmacological Society.
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Partyka, Anna; Wasik, Anna; Jastrzębska-Więsek, Magdalena; Mierzejewski, Paweł; Bieńkowski, Przemysław; Kołaczkowski, Marcin; Wesołowska, Anna
2016-06-01
Behavioral and psychological symptoms of dementia (BPSD) include apathy, sleep problems, irritability, wandering, elation, agitation/aggression, and mood disorders such as depression and/or anxiety. Elderly patients are usually treated with second-generation antipsychotics; however, they present not enough efficacy against all symptoms observed. Hence, there still is an unmet need for novel pharmacotherapeutic agents targeted BPSD. A novel arylsulfonamide derivative ADN-1184 has been developed that possesses a preclinical profile of activity corresponding to criteria required for treatment of both psychosis and depressive symptoms of BPSD without exacerbating cognitive impairment or inducing motor disturbances. To broaden its pharmacological efficacy toward anxiety symptoms, its anxiolytic properties have been examined in common animal preclinical models in rats and mice. ADN-1184 significantly increased the number of entries into open arms measured in the elevated plus-maze test; however, it simultaneously increased parameters of exploratory activity. In the Vogel conflict drinking test, ADN-1184 dose-dependently and significantly increased the number of shocks accepted and the number of licks. Moreover, in mice, it also had specific anxiolytic-like activity in the four-plate test, and only negligible one at a specific mid-range dose measured in the spontaneous marble burying test. The obtained findings reveal that ADN-1184 displays anxiolytic-like activity in animal models of anxiety which employed punished stimuli. In its unusual combination of some anxiolytic action with already proven antipsychotic and antidepressant properties, and lack of any disruptive impact on learning and memory processes and motor coordination, ADN-1184 displays a profile that would be desired for a novel therapeutic for BPSD.
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Transformación de la aflatoxina B1 de alimentos, en el cancerígeno humano, aducto AFB1-ADN
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Magda Carvajal
2013-01-01
Full Text Available Las aflatoxinas (AF son metabolitos secundarios tóxicos principalmente de los hongos Aspergillus flavus y A. parasiticus, son potentes mutágenos y cancerígenos de alimentos y la exposición del hombre a ellas es continuo. Las AF se ligan al ADN, ARN y proteínas formando aductos AFB1-ADN que se acumulan por años y dañan desde los virus hasta el hombre. Es importante identificar y cuantificar estos aductos como biomarcadores de largo tiempo de riesgo de enfermedad, ya que originan mutaciones y cáncer, y están validados en animales y humanos. Las AF se activan en presencia del citocromo P450 como una molécula inestable 8,9 epóxido AFB1, que se liga al N7 de la guanina, y se transforma en los cancerígenos activos o aductos AFB1-Gua y, finalmente, en los aductos AFB1-FAPY y son una medida objetiva de la exposición humana a cancerígenos ambientales. Los aductos representan la exposición, absorción, distribución, metabolismo, reparación del ADN y cambio celular. Los temas tratados aquí son la formación de aductos AFB1-ADN, estudios in vitro e in vivo, exposición a una dieta con AFB1, efectos, desarrollo de cáncer y mutaciones en el gen supresor p53, rutas de exposición, vitaminas, tipos de aducto AFB1-ADN, metodología y su control.
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McDonnell Douglas Helicopter Company independent research and development: Preparing for the future
Haggerty, Allen C.
1988-01-01
During the 1970's and 80's, research has produced the technology that is seen in aircraft such as the LHX and future models. The technology is discussed that is reaching maturity and moving into the application stage of future programs. Technology is discussed in six major areas: advanced concepts, analysis techniques, structures, systems, simulation, and research and development facilities. The partnership of McDonnell Douglas Helicopter Co. and the government in developing these technologies is illustrated in several programs.
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MD-11 PCA - Research flight team egress
1995-01-01
This McDonnell Douglas MD-11 has parked on the flightline at NASA's Dryden Flight Research Center, Edwards, California, following its completion of the first and second landings ever performed by a transport aircraft under engine power only (on Aug. 29, 1995). The milestone flight, with NASA research pilot and former astronaut Gordon Fullerton at the controls, was part of a NASA project to develop a computer-assisted engine control system that enables a pilot to land a plane safely when its normal control surfaces are disabled. Coming down the steps from the aircraft are Gordon Fullerton (in front), followed by Bill Burcham, Propulsion Controlled Aircraft (PCA) project engineer at Dryden; NASA Dryden controls engineer John Burken; John Feather of McDonnell Douglas; and Drew Pappas, McDonnell Douglas' project manager for PCA.
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Adaptive Competency Acquisition: Why LPN-to-ADN Career Mobility Education Programs Work.
Coyle-Rogers, Patricia G.
Adaptive competencies are the skills required to effectively complete a particular task and are the congruencies (balance) between personal skills and task demands. The differences between the adaptive competency acquisition of students in licensed practical nurse (LPN) programs and associate degree nurse (ADN) programs were examined in a…
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Método para la replicación, amplificación o secuenciación de un ADN molde
Lázaro, José M.; Vega, Miguel de; Blanco Dávila, Luis; Salas, Margarita; Mencía, Mario
2009-01-01
Método para la replicación, amplificación o secuenciación de un ADN molde. La presente invención se encuadra dentro del campo de la biotecnología. Específicamente, se refiere a un método para llevar a cabo la replicación, la amplificación o la secuenciación de un ácido desoxirribonucleico con una ADN polimerasa del tipo 29 y a un kit para llevar a cabo dicho método.
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Kołaczkowski, M; Mierzejewski, P; Bieńkowski, P; Wesołowska, A; Newman-Tancredi, A
2014-01-01
Background and Purpose Many dementia patients exhibit behavioural and psychological symptoms (BPSD) that include psychosis, aggressivity, depression and anxiety. Antipsychotic drugs are frequently prescribed but fail to significantly attenuate mood deficits, may interfere with cognitive function and are associated with motor and cardiac side effects, which are problematic in elderly patients. A need therefore exists for drugs that are better suited for the treatment of BPSD. Experimental Approach We used in vitro cellular and in vivo behavioural tests to characterize ADN-1184, a novel arylsulfonamide ligand with potential utility for treatment of BPSD. Key Results ADN-1184 exhibits substantial 5-HT6/5-HT7/5-HT2A/D2 receptor affinity and antagonist properties in vitro. In tests of antipsychotic-like activity, it reversed MK-801-induced hyperactivity and stereotypies and inhibited conditioned avoidance response (MED = 3 mg·kg−1 i.p.). Remarkably, ADN-1184 also reduced immobility time in the forced swim test at low doses (0.3 and 1 mg·kg−1 i.p.; higher doses were not significantly active). Notably, up to 30 mg·kg−1 ADN-1184 did not impair memory performance in the passive avoidance test or elicit significant catalepsy and only modestly inhibited spontaneous locomotor activity (MED = 30 mg·kg−1 i.p.). Conclusions and Implications ADN-1184 combines antipsychotic-like with antidepressant-like properties without interfering with memory function or locomotion. This profile is better than that of commonly used atypical antipsychotics tested under the same conditions and suggests that it is feasible to identify drugs that improve BPSD, without exacerbating cognitive deficit or movement impairment, which are of particular concern in patients with dementia. PMID:24199650
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Daño en el ADN en leucocitos de equinos sometidos a esfuerzo físico
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Marcos Germán Muriel
2016-12-01
Full Text Available En los últimos años se ha observado un creciente interés por el estudio de los efectos beneficiosos y perjudiciales asociados al ejercicio. El objetivo del presente trabajo fue establecer la existencia de daño en el ADN en leucocitos circulantes de equinos sometidos a un test de ejercicio de alta intensidad y corta duración. La determinación del daño en el ADN se realizó mediante el ensayo cometa versión alcalina. Se usaron 5 equinos. Se extrajeron muestras de sangre al comenzar el ejercicio, al alcanzar la velocidad máxima, al finalizar el ejercicio y a los 30 días post ejercicio. Simultáneamente se realizaron ergoespirometrías continuas para determinar el consumo de oxígeno durante el ejercicio. La frecuencia relativa de células con daño en el ADN fue 0,122, 0,240, 0,210 y 0,100, mientras que el índice de daño en el ADN fue 11,8, 28,4, 23 y 10,4 UA. Se observaron incrementos significativos con respecto al tiempo basal y 30 días post ejercicio cuando los animales alcanzaron la máxima velocidad y al finalizar el ejercicio (p< 0,05. Se observó una alta correlación entre el consumo de oxígeno y las células con daño (r= 0,905, así como con el índice de daño (r= 0,935. Estos resultados sugieren que los factores inductores de daño genotóxico se producen mayoritariamente durante el esfuerzo físico y que probablemente se deban a radicales libres del oxígeno.
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Directory of Open Access Journals (Sweden)
Jorge Eduardo Ortiz Triviño
2000-10-01
Full Text Available En este artículo se presenta un modelo de codificación de Redes Neuronales Artificiales basado en computación con ADN mediante el cual es posible diseñar una red que sea capaz de responder adecuadamente ante cualquier impulso en su entrada. Se hace uso de las operaciones de manipulación de cadenas genéticas que se emplean a nivel de laboratorio en la actualidad y trabajos previos en computación con ADN que permiten una futura implementación de ese esquema. Se propone también una técnica de aprendizaje nueva basada en los conceptos de selección natural que aprovecha la capacidad de cómputo masivamente paralelo inherente a la estructura biológica del ADN.
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Extracción de ADN de Trypanosoma cruzi mediante tratamiento con bromuro de hexadecil-trimetil-amonio
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Marcela Escalante
1997-06-01
Full Text Available En el presente trabajo se describe un método rápido, sencillo y eficaz para la obtención de ADN genómico de Trypanosoma cruzi, libre de impurezas y fácil de manipular. Dicho procedimiento se basa en la lisis del parásito con SDS y remoción de proteínas mediante la digestión con proteinasa K, seguida de la precipitación selectiva de carbohidratos y proteínas residuales con bromuro de hexadecil-trimetil-amonio (CTAB. Finalmente, el ADN se extrae con cloroformo: alcohol isoamílico y se recupera de la fase acuosa mediante precipitación con isopropanol.
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Feasibility of an LPN to ADN Articulation Program at LSUA. Vocational Education Research.
Louisiana State Univ., Alexandria.
A feasibility study examined the need for and likelihood of success for a Licensed Practical Nurse (LPN) to Associate Degree in Nursing (ADN) articulation program for Louisiana State University (LSU) at Alexandria. Following a literature search on the theoretical establishment and implementation of such a program, three schools with successful…
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National Research Council Canada - National Science Library
1999-01-01
This report explains the accident involving American Airlines flight 1420, a McDonnell Douglas MD-82, which crashed after it overran the end of runway 4R during landing at Little Rock National Airport...
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Vacunas de ADN: inducción de la respuesta inmunitaria DNA Vaccines: Induction of the immune response
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Javier Mota-Sánchez
2009-01-01
Full Text Available La efectividad de las vacunas y la inmunización en la prevención de las enfermedades infecciosas es uno de los grandes avances de la medicina. En la actualidad, el acceso a la tecnología de punta en el área de la genómica y la proteómica ha hecho posible acelerar el desarrollo de nuevos modelos de vacunas con características mejoradas en aspectos fundamentales, como la inmunogenicidad y la seguridad. A casi dos décadas del primer informe, en el cual se demostró que un gen puede expresarse mediante la inyección directa de ADN desnudo, las vacunas de ADN han probado ser eficientes para inducir una respuesta inmunitaria protectora contra parásitos, virus y bacterias en diversos modelos animales. Esta revisión tiene por objetivo presentar un panorama general de las vacunas de ADN y los mecanismos mediante los cuales la inmunización con antígenos insertados en vectores de ADN (plásmidos inducen una respuesta inmunitaria.The effectiveness of vaccines and immunization in the prevention of infectious diseases is one of the greatest successes in medicine. In recent years, with access to cutting edge genomic and proteomic technology, it is possible to accelerate the development of new and improved vaccines with better immunogenicity and safety characteristics. Since the first report almost two decades ago, where it was demonstrated that gene expression is possible by directed injection of naked DNA, DNA vaccines have been proven to induce protective immune responses against parasites, virus and bacterium in diverse animal disease models. This review aims to present an overview about DNA vaccines and the mechanisms by which immune responses are induced after immunization with plasmid DNA-encoded antigens.
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García Hernández, Verónica
2009-01-01
El diseño de compuestos con capacidad de unión a secuencias específicas de ADN tiene gran importancia en farmacología dado que existen numerosos fármacos que tienen el ADN como diana y cuya actividad terapéutica se basa en la afinidad y selectividad de su interacción con el mismo. Por otro lado, estos ligandos de bajo peso molecular con capacidad de unión a secuencias predeterminadas de ADN pueden ser herramientas de gran utilidad en biología molecular. Para comprender en ...
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Baroreflexes of the rat. V. Tetanus-induced potentiation of ADN A-fiber responses at the NTS.
Tang, Xiaorui; Dworkin, Barry R
2007-12-01
In a long-term neuromuscular blocked (NMB) rat preparation, tetanic stimulation of the aortic depressor nerve (ADN) enhanced the A-fiber evoked responses (ERs) in the cardiovascular region, the nucleus of the solitary tract (dmNTS). The potentiation persisted for at least several hours and may be a mechanism for adaptive adjustment of the gain of the baroreflex, with functional implications for blood pressure regulation. Using a capacitance electrode, we selectively stimulated A-fibers and acquired a stable 10-h "A-fiber only" ER baseline at the dmNTS. Following baseline, an A+C-fiber activating tetanus was applied to the ADN. The tetanus consisted of 1,000 "high current" pulses (10 trains; 300 mus, 100 Hz, 1 s), with intertrain interval of 9 s. A 10-h A-fiber only posttetanic test phase repeated the stimulus pattern of the baseline. Fourteen tetanus experiments were done in 12 rats. Compared with the baseline before tetanus, the A-fiber ER magnitudes of posttetanus hours were larger [F(13, 247) = 3.407, P ADN A+C fiber-activating tetanus produced increases in the magnitude of the A-fiber ERs in the dmNTS that persisted for several hours. In an additional rat, application of an NMDA receptor antagonist, prior to the tetanus, blocked the potentiation effect. The stimulus protocols, magnitude and duration of the effect, and pharmacology resemble associative long-term potentiation (LTP).
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Directory of Open Access Journals (Sweden)
Javier Andres Bustamante
2011-05-01
Full Text Available Los tejidos de archivo son un material de incalculable valor para estudios retrospectivos que requieran la aplicación de análisis moleculares. Existen múltiples métodos de extracción de ADN a partir de este tipo de muestras. No obstante, la mayoría de métodos toman mucho tiempo y los reactivos empleados contribuyen a la fragmentación del ADN. Con el objetivo de optimizar dos métodos de extracción de ADN a partir de tejidos embebidos en parafina en condiciones no optimas. Se seleccionaron 47 bloques en parafina que contenían biopsias de pleura, pulmón y pericardio correspondientes a 24 pacientes (66,66%hombres mayores de 18 años, con inflamación granulomatosa crónica, remitidos al Departamento de Patología del Hospital Universitario del Valle entre 2002-2007. A cada muestra se le realizaron 10 cortes y se sometieron a dos métodos de extracción de ADN: 1.Convencional y 2.QIAamp-DNA mini kit®. La eficiencia del ADN fue valorada por espectrofotometría y amplificación del gen GAPDH. La concentración de ADN de las muestras extraídas por el método convencional fue de 65.52ng/µl ±11.47 (promedio±EE y la relación 260/280 vario entre 0.52 y 2.30. De las muestras extraídas por el método comercial, la concentración media de ADN fue 60.89ng/µl±6.02, con una absorbancia que oscilo entre 0 y 2.64. El ADN obtenido fue sometido a PCR, de 47 muestras extraídas por ambos métodos, 25 y 23 respectivamente amplificarón exitosamente el gen GAPDH. Los métodos usados para la obtención de ADN presentaron un desempeño similar, revelando así su potencial utilidad en estudios retrospectivos a partir de biopsias embebidas en parafina en condiciones inadecuadas.
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Directory of Open Access Journals (Sweden)
Iriarte, E.
2011-01-01
Full Text Available Los estudios de ADN antiguo están permitiendo conocer nuevos datos sobre la biología de especies actuales y extintas. Las técnicas de ADN antiguo pueden ser una herramienta adicional y complementaria dentro de los estudios multidisciplinares que son necesarios para abordar distintas problemáticas arqueopaleontológicas. En este artículo repasamos algunas de las aplicaciones en estos contextos: la determinación taxonómica y sexual, los estudios para conocer el proceso de domesticación, o la estructura filogeográfica durante ciclos glaciares subrayando la existencia o no de refugios glaciares. También proporcionamos información preliminar referente a la aplicación de estas técnicas en el yacimiento de Arlanpe (Lemoa, Bizkaia. En este yacimiento hemos obtenido ADN mitocondrial de muestras de oso pardo, gran bóvido y cabra montés. Una de las muestras de oso pardo de Arlanpe está dentro del clado 3c compuesto de osos pardos extintos de Alaska. Dos de las muestras de gran bóvido de Arlanpe han sido clasificadas como uro (Bos primigenius mediante métodos genéticos.
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LOS METALES COMO INHIBIDORES DEL SISTEMA DE REPARACIÓN DEL ADN
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Pablo Hernández-Franco
2009-01-01
Full Text Available Los humanos han estado en contacto con los metales desde su aparición en el planeta. De hecho no se puede pensar en la evolución humana sin pensar en el gran papel que han jugado los metales en el desarrollo humano. Algunos metales son esenciales para llevar a cabo procesos celulares, sin embargo, otros son capaces de promover una gran variedad de efectos deletéreos para la salud, incluyendo el cáncer. Las evidencias de que la inhibición de los mecanismos de reparación del ADN, es un importante paso para que se lleve a cabo la carcinogénesis inducida por los metales cobran día a día más importancia, sin embargo, es poco probable que exista un mecanismo de acción común para todos los metales debido a que presentan propiedades químicas diversas. En la presente revisión, se discutirá el papel de los metales en la inhibición de los mecanismos de reparación, poniendo énfasis en algunos mecanismos de acción propuestos como son: la inactivación de enzimas, la unión a componentes celulares, la inducción de daño al ADN, entre otros.
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Student and faculty perceptions of effective clinical instructors in ADN programs.
Gignac-Caille, A M; Oermann, M H
2001-11-01
The purpose of this study was to identify the perceptions of associate degree nursing (ADN) students and faculty of characteristics of effective clinical teachers and determine whether there were differences between these two groups. A survey was conducted of 292 students in various levels of their ADN programs and 59 faculty members from the same five programs, which were randomly selected from across Michigan. Data were collected using the Nursing Clinical Effectiveness Inventory, which includes 48 characteristics of effective clinical instructors arranged in five subscales. Students identified "demonstrates clinical skills and judgment" as the most important characteristic of effective clinical instructors, while faculty identified "explains clearly" as the most important characteristic. There was agreement on 6 of the top 10 characteristics identified by both groups. Both groups rated "directs student to useful literature in nursing" as the least important characteristic of effective clinical instructors. The students' and faculty's perceptions of effective clinical instructors differed by subscales, with students identifying evaluation characteristics as most important (mean = 4.73, SD = .42) and faculty identifying interpersonal relationships as most important (mean = 4.72, SD = .31). A t test indicated a significant difference between student and faculty means for the interpersonal relationships subscales, with faculty rating this group of characteristics as more important than students did (t = 2.49, p = .0 14).
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Estandarización de un protocolo sencillo para la extracción de ADN genómico de levaduras
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Esteban Osorio-Cadavid
2009-01-01
Full Text Available Se estandarizó un protocolo rápido, sencillo y de bajo costo para la extracción de ADN genómico de levaduras a partir de lisis de la pared celular mediante tratamiento enzimático y precipitación por alcoholes. El empleo de la enzima Beta-glucoronidasa en reemplazo de la enzima Zimolasa, permitió obtener ADN en alta concentración (124,9±30,2 ng/μl y de buena calidad (A260/A280 nm =1,86±0,1, ideal para su uso en estudios de biología molecular. Además, se adicionó un paso de incubación del ADN obtenido a 100° C para inactivar ADNasas. La calidad del ADN obtenido fue evaluada por medio de la amplificación de la región ITS1-5.8S-ITS2, presentando bandas definidas y cuantificables (entre 380 y 880 pb ideales para estudios de identificación molecular y filogenia. Abstract: A quick, simple and low-cost protocol for extracting genomic DNA from yeast by cell wall lysis involving enzymatic treatment and alcoholic precipitation was standardised. Higher DNA yields (124.9±30.2 ng/μl were obtained by using beta-glucuronidase instead of zymolyase; these had very high quality (A260/A280 nm = 1.86±0.1 and would be suitable for use in molecular biology assays. Moreover, a DNAse inactivation step was also introduced by incubation at 100 °C to further ensure DNA stability. DNA quality was assayed by PCR amplification of the ITS1-5.8S-ITS2 region, revealing defined, quantifiable 380 to 880 bp bands. These results show that the protocol is ideal for molecular identification and phylogenetic studies.
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2010-05-17
... Airworthiness Directives; McDonnell Douglas Corporation Model DC- 9-30, DC-9-40, and DC-9-50 Series Airplanes... airworthiness directive (AD) for certain Model DC-9-30, DC-9-40, and DC-9-50 series airplanes. This AD requires... this AD to detect and correct the potential for an arc/spark condition to occur within the fuel boost...
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Rosenberg, Carolina Elena
2014-01-01
Teniendo como hipótesis que la representación gráfica de la replicación del ADN utilizada habitualmente genera una comprensión inadecuada del proceso, y que la utilización de una representación alternativa que sitúa las horquillas en el interior de una o varias burbujas de replicación mejora la comprensión del proceso, se presenta una secuencia de estrategias de enseñanza con el objetivo de contribuir a la mejor comprensión del proceso de replicación del ADN Bearing the hypothesis that the...
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Directory of Open Access Journals (Sweden)
Rosana Gariglio
2004-10-01
Full Text Available La terapia antirretroviral de alta eficacia (TAAE induce una reducción marcada y persistente de la viremia plasmática, contribuyendo a disminuir la mortalidad y morbilidad de los pacientes HIV-positivos. Así, la carga viral (CV es el método de referencia para evaluar la eficacia terapéutica. Sin embargo, aun en presencia de una TAAE eficiente no se ha logrado la erradicación viral. En este estudio analizamos la presencia del ADN total de HIV (ADN HIV-T, del ADN no integrado con 2LTR (ADN HIV-2LTR y del ARN de HIV, en un grupo de 55 pacientes HIV-positivos en distintos estadios clínicos, con y sin TAAE, mediante ensayos de PCR con revelado colorimétrico en microplaca, optimizados en nuestro laboratorio. La sensibilidad clínica del ARN del HIV fue evaluada con el bDNA, resultando del 74% y del 64%, respectivamente, con una concordancia del 85%. Este ensayo podría ser utilizado en el seguimiento de pacientes bajo TAAE. El ADN HIV-2LTR resultó positivo en el 54% aunque estuvo ausente en pacientes con elevada CV. Este marcador se consideraba un producto lábil y su presencia se asociaba a infección reciente. Sin embargo, actuales evidencias ponen en discusión su estabilidad por lo que su significado clínico debe ser reconsiderado. La ausencia del ADN HIV-2LTR en pacientes con CV detectable puede relacionarse con la heterogeneidad de la secuencia utilizada para su detección. El ADN HIV-T estuvo presente en el 100% de las muestras y resultaría relevante como marcador de remisión cuando se dispongan de terapias que efectivamente erradiquen la infección.Highly active antiretroviral therapy (HAART induces a persistent reduction of the plasmatic viremia, contributing to decrease mortality and morbidity of infected people with human immunodeficiency virus (HIV. Thus, viral load (VL is the reference method to evaluate therapy effectiveness. However, even in the presence of efficient HAART viral eradication was yet not achieved. In this
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International Nuclear Information System (INIS)
Yu, Yu-Song; Li, Guo-Xiu; Zhang, Tao; Chen, Jun; Wang, Meng
2015-01-01
Highlights: • The decomposition and combustion process is investigated by numerical method. • Heat transfer in catalyst bed is modeled using non-isothermal and radiation model. • The wall heat transfer can impact on the distribution of temperature and species. • The value of catalyst bed length, diameter and wall thickness are optimized. - Abstract: The present investigation numerically studies the evolutions of decomposition and combustion within an ADN-based thruster, and the effects of the catalyst-bed’s three structure parameters (length, diameter, and wall thickness) on the general performance of ADN-based thruster have been systematically investigated. Based upon the calculated results, it can be known that the distribution of temperature gives a Gaussian manner at the exits of the catalyst-bed and the combustion chamber, and the temperature can be obviously effected by each the three structure parameters of the catalyst-bed. With the rise of each the three structure parameter, the temperature will first increases and decreases, and there exists an optimal design value making the temperature be the highest. Via the comparison on the maximal temperature at combustion chamber’s exit and the specific impulse, it can be obtained that the wall thickness plays an important role in the influences on the general performance of ADN-based thruster while the catalyst-bed’s length has the weak effects on the general performance among the three structure parameters.
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Development Testing of 1-Newton ADN-Based Rocket Engines
Anflo, K.; Gronland, T.-A.; Bergman, G.; Nedar, R.; Thormählen, P.
2004-10-01
With the objective to reduce operational hazards and improve specific and density impulse as compared with hydrazine, the Research and Development (R&D) of a new monopropellant for space applications based on AmmoniumDiNitramide (ADN), was first proposed in 1997. This pioneering work has been described in previous papers1,2,3,4 . From the discussion above, it is clear that cost savings as well as risk reduction are the main drivers to develop a new generation of reduced hazard propellants. However, this alone is not enough to convince a spacecraft builder to choose a new technology. Cost, risk and schedule reduction are good incentives, but a spacecraft supplier will ask for evidence that this new propulsion system meets a number of requirements within the following areas: This paper describes the ongoing effort to develop a storable liquid monopropellant blend, based on AND, and its specific rocket engines. After building and testing more than 20 experimental rocket engines, the first Engineering Model (EM-1) has now accumulated more than 1 hour of firing-time. The results from test firings have validated the design. Specific impulse, combustion stability, blow-down capability and short pulse capability are amongst the requirements that have been demonstrated. The LMP-103x propellant candidate has been stored for more than 1 year and initial material compatibility screening and testing has started. 1. Performance &life 2. Impact on spacecraft design &operation 3. Flight heritage Hereafter, the essential requirements for some of these areas are outlined. These issues are discussed in detail in a previous paper1 . The use of "Commercial Of The Shelf" (COTS) propulsion system components as much as possible is essential to minimize the overall cost, risk and schedule. This leads to the conclusion that the Technology Readiness Level (TRL) 5 has been reached for the thruster and propellant. Furthermore, that the concept of ADN-based propulsion is feasible.
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Foronda, Cynthia L; Belknap, Ruth Ann
2012-06-03
ADN students are a large yet distinct subgroup of nursing students who require research and understanding. The purpose of this study was to describe the thoughts, feelings, and experiences of American associate degree nursing (ADN) students who participated in a short study abroad course in a low-income country. A qualitative, narrative method was used. Three categories emerged from the analysis. Participants revealed thoughts of "constant comparisons", feelings of an "emotional journey", and they experienced "learning". Participants did not demonstrate perspective transformation as defined by Mezirow as participants signified no intent for social action. Several potential blocks to perspective transformation were identified: egocentrism/emotional disconnect, perceived powerlessness/being overwhelmed, and a vacation mindset. The findings provide insight into the student experience of studying abroad. Transformative learning is not a guaranteed result. Nurse educators must consider strategies to foster transformation including discussing global systemic oppressors, international relations, coping, connecting, and social action.
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Jin, Ruofei; Liu, Tianqi; Liu, Guangfei; Zhou, Jiti; Huang, Jianyu; Wang, Aijie
2015-02-01
Recent research has highlighted the existence of some bacteria that are capable of performing heterotrophic nitrification and have a phenomenal ability to denitrify their nitrification products under aerobic conditions. A high-salinity-tolerant strain ADN-42 was isolated from Hymeniacidon perleve and found to display high heterotrophic ammonium removal capability. This strain was identified as Pseudomonas sp. via 16S rRNA gene sequence analysis. Gene cloning and sequencing analysis indicated that the bacterial genome contains N2O reductase function (nosZ) gene. NH3-N removal rate of ADN-42 was very high. And the highest removal rate was 6.52 mg/L · h in the presence of 40 g/L NaCl. Under the condition of pure oxygen (DO >8 mg/L), NH3-N removal efficiency was 56.9 %. Moreover, 38.4 % of oxygen remained in the upper gas space during 72 h without greenhouse gas N2O production. Keeping continuous and low level of dissolved oxygen (DO <3 mg/L) was helpful for better denitrification performance. All these results indicated that the strain has heterotrophic nitrification and aerobic denitrification abilities, which guarantee future application in wastewater treatment.
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1990-12-03
This is our final report on the audit of Subcontract Prices on Firm-Fixed-Price Contracts Awarded to McDonnell Aircraft Company (MCAIR). The Contract Management Directorate made the audit from October 1989 through June 1990. The objective of the audit was to compare proposed and negotiated subcontract prices and determine reasons for significant variances. We also evaluated applicable internal control procedures. For a 6-month period ending December 1989, MCAIR issued 517 subcontracts valued at $679 million.
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Directory of Open Access Journals (Sweden)
Alexandra Castañeda
2004-09-01
Full Text Available El género Cryptococcus comprende, al menos, 38 especies, pero sólo 3 se han informado como patógenas para el hombre y los animales: Cryptococcus laurentii, Cryptococcus albidus y Cryptococcus neoformans; esta última es la más frecuente. La infección se adquiere por la inhalación de los propágulos infectantes del medio ambiente. Los estudios del hábitat se han realizado con técnicas de extracción con soluciones tampón y cultivos en medios selectivos. El objetivo del trabajo fue evaluar varias técnicas de extracción del ADN de Cryptococcus spp. a partir de muestras ambientales. Como controles se emplearon aislamientos de C. neoformans, C. albidus, C. laurentii y Paracoccidiodes brasiliensis. Se emplearon vermiculitas, suelos contaminados en el laboratorio con 10 a 106 blastoconidias/g y muestras naturalmente colonizadas con C. neoformans. El ADN se extrajo con métodos físicos, químicos y con un estuche comercial, y se purificó usando bloques de agarosa y columnas de sílica. Para la amplificación con PCR se emplearon los iniciadores CN4-CN5 específicos para C. neoformans. Sólo el estuche comercial permitió extraer y purificar el ADN de las muestras de suelos contaminados hasta una concentración de 10 blastoconidias/g de suelo y de una de las muestras naturalmente colonizadas. Con este trabajo se logró la extracción y amplificación de ADN de Cryptococcus spp. a partir de muestras ambientales lo cual constituye una herramienta importante para delimitar las áreas ecológicas de C. neoformans en nuestro país.
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The ADN project : an integrated seismic monitoring of the northern Ecuadorian subduction
Nocquet, Jean-Mathieu; Yepes, Hugo; Vallee, Martin; Mothes, Patricia; Regnier, Marc; Segovia, Monica; Font, Yvonne; Vaca, Sandro; Bethoux, Nicole; Ramos, Cristina
2010-05-01
The subduction of the Nazca plate beneath South America has caused one of the largest megathrust earthquake sequence during the XXth century with three M>7.7 earthquakes that followed the great 1906 (Mw = 8.8) event. Better understanding the processes leading to the occurrence of large subduction earthquakes requires to monitor the ground motion over a large range of frequencies. We present a new network (ADN) developed under a collaboration between the IRD-GeoAzur (Nice, France) and the IG-EPN (Quito, Ecuador). Each station of the ADN network includes a GPS recording at 5 Hz, an accelerometer and a broadband seismometer. CGPS data will quantify the secular deformation induced by elastic locking along the subduction interface, enabling a detailed modelling of the coupling distribution. CGPS will be used to monitor any transient deformation induced by Episodic Slip Event along the subduction, together with broadband seismometers that can detect any tremors or seismic signatures that may accompany them. In case of any significant earthquake, 5 Hz GPS and accelerometer will provide near field data for earthquake source detailed study. Finally, the broadband seismometers will be used for study of the microseismicity and structure of the subduction zone. The network includes 9 stations, operating since 2008 and covering the coastal area from latitude 1.5°S to the Colombian border. In this poster, we will present preliminary assessment of the data, first hypocenters location, magnitude and focal mechanism determination, as well as results about an episodic slip event detected in winter 2008.
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Tariq Khalil, Talat; Taillefumier, Baptiste; Boulanouar, Omar; Mavon, Christophe; Fromm, Michel
2016-09-01
L'environnement chimique de l'ADN en situation biologique est complexe notam-ment en raison de la présence d'histones, protéines nucléaires, associées en quantité approximativement égales à l'ADN pour former la chromatine. Les histones possèdent de nombreux radicaux basiques arginine et lysine chargés positivement et dont la majorité se trouve sur les chaînes émergentes, l'ADN présente quant à lui des charges négatives sur ses groupements phosphates localisés tout au long de la double hélice. Dans cette étude, la complexité de la structure de la chromatine nucléaire est dans un premier temps mimée en solution aqueuse par la formation de complexes entre un ADN plasmidique sonde et les trois acides aminés basiques, Arg, His, Lys, qui, mis à part His, sont protonés au pH physiologique. Ces acides aminés libres en solution sont réputés être des capteurs efficaces de radicaux libres, notamment pour le radical hydroxyle, conférant ainsi un pouvoir protecteur vis-à-vis des effets indirects sur l'ADN en situation d'exposition aux rayonnements ionisants. A concentration fixée, les capacités de capture des acides aminés libres, σ, pour le radical hydroxyle sont typiquement les suivantes σHis ≈σArg > σLys (σLys ≈ 0,1 × σArg). Nous avons mesuré les taux de cassures simple brin par plasmide et par Gray (χ) lors d'expositions de solutions aqueuses de complexes [acide aminé - ADN plasmidique] aux rayons X ultra-mous (1,5 keV). A concentrations égales, les trois acides aminés complexés et présents en large excès ne manifestent pas une capacité de protection de l'ADN proportionnelle à leur capacité de capture libre et en solution ; on trouve en effet des taux de cassures dans l'ordre suivant χHis > χArg > χLys (χLys ≈ 0,01 χArg). Après avoir détaillé le mode opératoire de ces mesures, nous analyserons sur des bases bibliographiques, les modes spécifiques d'interaction des acides aminés basiques avec l'ADN. La sp
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Toossi, Mostafa; Weisenburger, Richard; Hashemi-Kia, Mostafa
1993-01-01
This paper presents a summary of some of the work performed by McDonnell Douglas Helicopter Company under NASA Langley-sponsored rotorcraft structural dynamics program known as DAMVIBS (Design Analysis Methods for VIBrationS). A set of guidelines which is applicable to dynamic modeling, analysis, testing, and correlation of both helicopter airframes and a large variety of structural finite element models is presented. Utilization of these guidelines and the key features of their applications to vibration modeling of helicopter airframes are discussed. Correlation studies with the test data, together with the development and applications of a set of efficient finite element model checkout procedures, are demonstrated on a large helicopter airframe finite element model. Finally, the lessons learned and the benefits resulting from this program are summarized.
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Uso de la técnica SSCP para detectar mutaciones puntuales del ADN mitocondrial humano
Directory of Open Access Journals (Sweden)
Alejandro Estrada-Cuzcano
2013-05-01
Full Text Available En el presente trabajo se evalúa la técnica de SSCP (polimorfismo de conformación de cadena individual de ADN para detectar mutaciones puntuales, tanto por su sensibilidad en la detección (alrededor 80% en condiciones ideales, como por su implementación fácil y económica. Se utilizaron como controles positivos y negativos, ADN de voluntarios caracterizados previamente para las mutaciones puntuales de 5 RFLPs mitocondriales. Para la optimización de la prueba fueron ensayadas concentraciones variables del tampón TBE (1X y 0,5X y del glicerol (10%, 5% y 0 en geles de poliacrilamida. Cuatro de los 5 RFLPs fueron detectados en las condiciones utilizadas y pueden ser usados en estudios de rutina sin usar enzimas de restricción. Además, la técnica SSCP permitió determinar mutaciones desconocidas en un segmento de 394 nucleótidos de la región hipervariable (HVI del ADNmt. Diferencias en correspondencia a los distintos haplotipos fueron detectados e incluso permitió discernir grupos dentro del mismo subtipo. La secuenciación de dos muestras del subtipo B1 con migración diferencial en SSCP, corroboró la existencia de siete nucleótidos distintos
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RN-BSN Students' Perceptions of the Differences in Practice of the ADN- and BSN-Prepared RN.
Matthias, April D; Kim-Godwin, Yeoun Soo
2016-01-01
This study explored RN-BSN students' perceptions of practice differences between nurses prepared with an ADN and BSN. Five themes were identified in 20 students' discussion posts: "a nurse is a nurse" at the bedside, beyond the bedside, BSN wanted, digging deeper, and appraisal. Results illustrate the need for educators to assist nurses in translating the differentiated educational competencies to the practice role of the bedside RN.
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Localización in situ de heterocromatina -ADN satélite- en cromosomas humanos
Directory of Open Access Journals (Sweden)
Emilio Yunis T.
1971-07-01
Full Text Available Se presenta un trabajo en base a la técnica de localización in situ de heterocromatina constitutiva de tipo repetitivo ADN satélite. Se discute su constancia y valor para diferenciar los pares de cromosomas del grupo D, G, A y cromosomas Y. Se insiste en la posible universalidad del procedimiento, confrontado con las restricciones que presenta la técnica de la fluorescencia con quinacrina, aparentemente limitada su positividad a primates superiores.
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Directory of Open Access Journals (Sweden)
M.E.K ABDELMOUMENE
2009-06-01
Full Text Available L’ADN, support de l’information génétique de la cellule, est la cible la plus importante lors d’une exposition à un rayonnement ionisant (radiothérapie, scintigraphie…. Sa dégradation est à l’origine de désordres cellulaires dramatiques comme la cancérisation. Pour quantifier ces effets, nous avons considéré deux électrons d’énergie incidente 1 KeV qui traversent un milieu aqueux fournissant chacun une distribution de radicaux libres (e-aq, H,OH, H+aq, H2, H2O2, OH-, O2, O-2, OH2, OH2- que nous avons fait évoluer selon un ensemble de codes informatiques élaborés sur un modèle déterministe jusqu’à leur collision et estimer ainsi la concentration et le rendement de chaque espèce. Dans cette étude, nous n’avons considéré queles espèces les plus agressives vis à vis des molécules biologiques e-aq, H et plus particulièrement l’hydroxyle OH. Nous avons ainsi estimé le nombre moyensde diverses lésions portées à l’ADN. L’intérêt essentiel de cette étude est lamise au point d’un modèle simple d’adaptation facile du point de vue applications qui peut renseignersur les dommages causés à une molécule aussi importante que l’ADN.
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Electro-optical rendezvous and docking sensors
Tubbs, David J.; Kesler, Lynn O.; Sirko, Robert J.
1991-01-01
Electro-optical sensors provide unique and critical functionality for space missions requiring rendezvous, docking, and berthing. McDonnell Douglas is developing a complete rendezvous and docking system for both manned and unmanned missions. This paper examines our sensor development and the systems and missions which benefit from rendezvous and docking sensors. Simulation results quantifying system performance improvements in key areas are given, with associated sensor performance requirements. A brief review of NASA-funded development activities and the current performance of electro-optical sensors for space applications is given. We will also describe current activities at McDonnell Douglas for a fully functional demonstration to address specific NASA mission needs.
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ADN* Density log estimation Using Rockcell*
International Nuclear Information System (INIS)
Okuku, C.; Iloghalu, Emeka. M.; Omotayo, O.
2003-01-01
This work is intended to inform on the possibilities of estimating good density data in zones associated with sliding in a reservoir with ADN* tool with or without ADOS in string in cases where repeat sections were not done, possibly due to hole stability or directional concerns. This procedure has been equally used to obtain a better density data in corkscrew holes. Density data (ROBB) was recomputed using neural network in RockCell* to estimate the density over zones of interest. RockCell* is a Schlumberger software that has neural network functionally which can be used to estimate missing logs using the combination of the responses of other log curves and intervals that are not affected by sliding. In this work, an interval was selected and within this interval twelve litho zones were defined using the unsupervised neural network. From this a training set was selected based on intervals of very good log responses outside the sliding zones. This training set was used to train and run the neural network for a specific lithostratigraphic interval. The results matched the known good density curve. Then after this, an estimation of the density curve was done using the supervised neural network. The output from this estimation matched very closely in the good portions of the log, thus providing some density measurements in the sliding zone. This methodology provides a scientific solution to missing data during the process of Formation evaluation
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La Madeleine, Carole
Ce memoire est presente a la Faculte de medecine et des sciences de la sante de l'Universite de Sherbrooke en vue de l'obtention du grade de maitre es sciences (M.Sc.) en radiobiologie (2009). Un jury a revise les informations contenues dans ce memoire. Il etait compose de professeurs de la Faculte de medecine et des sciences de la sante soit : Darel Hunting PhD, directeur de recherche (departement de medecine nucleaire et radiobiologie), Leon Sanche PhD, directeur de recherche (departement de medecine nucleaire et radiobiologie), Richard Wagner PhD, membre du programme (departement de medecine nucleaire et radiobiologie) et Guylain Boissonneault PhD, membre exterieur au programme (departement de biochimie). Le 5-bromodeoxyuridine (BrdU), un analogue halogene de la thymidine reconnu depuis les annees 60 comme etant un excellent radiosensibilisateur. L'hypothese la plus repandue au sujet de l'effet radio sensibilisant du BrdU est qu'il augmente le nombre de cassures simple et double brin lorsqu'il est incorpore dans l'ADN de la cellule et expose aux radiations ionisantes. Toutefois, de nouvelles recherches semblent remettre en question les observations precedentes. Ces dernieres etudes ont confirme que le BrdU est un bon radiosensibilisateur, car il augmente les dommages radio-induits dans l'ADN. Mais, c'est en etant incorpore dans une region simple brin que le BrdU radiosensibilise l'ADN. Ces recherches ont egalement revele pour la premiere fois un nouveau type de dommages produits lors de l'irradiation de l'ADN contenant du BrdU : les dimeres interbrins. Le but de ces travaux de recherche est de determiner si la presence de bromodeoxyuridine dans l'ADN augmente l'induction de bris simple et / ou double brin chez les cellules irradiees en utilisant de nouvelles techniques plus sensibles et specifiques que celles utilisees auparavant. Pour ce faire, les essais cometes et la detection des foci H2AX phosphorylee pourraient permettre d'etablir les effets engendres par
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Outcomes of ADN-BSN partnerships to increase baccalaureate prepared nurses.
Sizemore, Mary H; Robbins, Leslie K; Hoke, Mary M; Billings, Diane M
2007-01-01
The limited supply of BSN nurses hinders efforts to increase patient care quality and address health disparities. In largely rural and economically disadvantaged areas, associate degree prepared nurses provide the majority of nursing services. To address a statewide need, a BSN Program and 3 ADN Programs formed a partnership to take BSN education to rural and medically underserved areas. This article describes the program planning, implementation, and evaluation using an adapted assessment framework with partnership principles as its foundation. Interactive television, internet education components, local clinical experiences, and distant nursing faculty liaisons were used. The nursing course sequence was completed by 101 of 102 students. Hall's Professionalism Scale, the California Critical Thinking Disposition Inventory, and the California Critical Thinking Skills Test measured the increases found in professional socialization and critical thinking. Use of the adapted theoretical framework represented a strategic approach to developing a distance delivered nursing education program.
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Secuencia genética y dinámica de excitaciones no lineales de ADN
Cuenda Cuenda, Sara
2007-01-01
La memoria se divide en tres partes: la que se refiere al modelo de sine-Gordon continuo; la segunda, relativa al modelo de sine-Gordon discreto; y la última, que trata el modelo de Peyrard-Bishop aplicado al ADN. La primera parte engloba los capítulos 2 y 3. El segundo capítulo es puramente introductorio, y trata del modelo de sine-Gordon homogéneo y continuo. En él se hace un repaso de la ecuación de sine-Gordon en coordenadas características en la geometría diferencial y ...
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Cahuzac, B.; Félenbok, B.; Guittet, E.
1999-10-01
Aspergillus nidulans is a filamentous fungus able to use ethanol as sole energy source. The activation of the ethanol regulon genes expression is mediated by the AlcR protein. Its DNA-binding domain is located in the N-terminus (residues 1 to 60), and its NMR solution structure shows a global zinc binuclear cluster fold, with two helices in addition to the basic binuclear motif. A small number of crystallographic structures of DNA complexes of binuclear cluster proteins is yet known, and points out the major groove and the first helix as the principal sites of interaction on the DNA and the protein respectively. In this article we show evidences that the N-terminus of the protein is involved in binding to the minor groove. Aspergillus nidulans est un champignon filamenteux capable d'utiliser l'éthanol comme source unique d'énergie. La protéine AlcR est responsable de l'activation de l'expression des gènes du régulon éthanol. Le domaine de liaison à l'ADN est situé dans la partie N-terminale de la protéine (a.a. 1 à 60), et sa structure déterminée par RMN en solution montre un repliement global en bouquet binucléaire à zinc, avec deux hélices supplémentaires par rapport au motif de base. Alors que les structures déjà connues de complexes ADN - bouquets binucléaires permettent de situer dans le grand sillon la quasi-totalité des interactions, nous montrons dans la présente étude l'implication du début de la séquence dans la reconnaissance du petit sillon de l'ADN (a.a. 5 et 6).
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Distinción de especies del género Persea mediante RAPD e ISSR de ADN
Reyes-Alemán, Juan Carlos; Valadez-Moctezuma, Ernestina; Simuta-Velázco, Lisandro; Barrientos-Priego, Alejandro Facundo; Gallegos-Vázquez, Clemente
2013-01-01
Con la finalidad de establecer bases para diferenciar parte de la diversidad genética de Persea y en especial del subgénero Persea resguardado en la colección nacional de germoplasma de aguacate de México, se estudiaron ocho especies (P. americana, P. steyermarkii, P. schiedeana, P. lingue, P. nubigena, P. floccosa, P. cinerascens y P. indica) con marcadores moleculares mediante las técnicas de RAPD e ISSR, donde los productos de PCR fueron separados en geles de acrilamida. Las huellas de ADN...
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Analysis of solar thermophotovoltaic test data from experiments performed at McDonnell Douglas
Energy Technology Data Exchange (ETDEWEB)
Stone, K.W.; Kusek, S.M.; Drubka, R.E. [McDonnell Douglas, 5301 Bolsa Avenue, Huntington Beach, California 92647 (United States); Fay, T.D. [21911 Bacalar, Mission Viejo, California 92692 (United States)
1995-01-05
Solar thermophotovoltaic power systems offer potentially high system efficiency for solar energy to electrical energy conversion and attractive system advantages. McDonnell Douglas Corporation (MDC) has been investigating this technology for both space and terrestrial applications for several years. A testbed prototype was designed, built, and tested on a 90 kW{sub t} dish concentrator at the MDA solar test facility. Twelve experiments were conducted with absorber temperatures in excess of 1300 {degree}C being achieved using only a fraction of the reflected power from the 90 kW{sub t} dish concentrator. This paper discusses the solar thermophotovoltaic testbed prototype unit, test data, and presents an analysis of the unit`s performance. A combination of analytical analysis and test data is used to obtain an understanding of the system and subsystem performance. The preliminary results of these tests and analysis indicate a solar thermophotovoltaic power system can achieve high system performance. Furthermore, system demonstrations are possible utilizing a combination of current off-the-shelf hardware components and components currently being tested in laboratories. {copyright} {ital 1995} {ital American} {ital Institute} {ital of} {ital Physics}.
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A unique strategy for pediatric community health nursing for ADN students.
Janvier, K A
1999-01-01
Students were overwhelmingly positive when given the opportunity to evaluate the pilot project and the model of pediatric community health nursing. According to the students, the strong points of the model were the orientation before the community experience, the presence of faculty of the community, the ability to contact faculty when needed, and the postclinical conference. The students' comments confirmed the faculty's belief that a clinical experience in community health nursing must place more emphasis on the specialty of community health nursing to be meaningful for students. To do the of job of educating tomorrow's nurses, ADN faculty should develop new strategies for teaching the pediatric clinical component of community health nursing. Clearly, hospitals are no longer the exclusive sites where students learn about patient and family needs and nursing care delivery. Community-based and community-focused experiences will continue to be required so that nursing students are prepared to practice in a dynamic and changing healthcare environment.
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Directory of Open Access Journals (Sweden)
Ana Teresa Herrera-Reveles
2012-03-01
Full Text Available Con la finalidad de evaluar la asociación de índices de crecimiento en estadios tempranos de peces marinos, se estimó la tasa de crecimiento somático y las condiciones fisiológicas de Eucinostomus argenteus en dos zonas del nor-oriente venezolano: Bahía de Mochima y Golfo de Cariaco. La edad y el crecimiento fueron estimados basados en análisis de otolitos sagitta. Las condiciones fisiológicas fueron evaluadas por medio de las concentraciones de proteínas y la relación ARN/ADN, empleando técnicas espectofotométricas y fluorométricas sobre tejido muscular. Las relaciones entre tallas con la edad y el diámetro de los otolitos resultaron positivas, significativas y ajustadas a un modelo de regresión lineal. Los valores de la tasa de crecimiento reciente oscilaron entre 0.178 y 0.418mm día-1, la tasa de crecimiento retrocalculado varió entre 0.295 y 0.393mm día-1, y la tasa ARN/ADN osciló entre 1.65 y 6.97. No se registraron diferencias entre las zonas de estudio, sin embargo se reportaron diferencias entre localidades. A pesar de no encontrarse correlación entre la tasa de crecimiento y la relación ARN/ADN, los valores reportados sugieren crecimiento positivo de los individuos silvestres en las localidades evaluadas. No obstante, ciertas localidades mostraron valores que indican pobres condiciones nutricionales, pudiendo afectarse a futuro otras tasas vitales.
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Directory of Open Access Journals (Sweden)
Wellman Ribón
2009-12-01
Conclusión. Se determinó que el protocolo de extracción de ADN descrito por van Soolingen et al. (2002 e implementado en el Instituto Nacional de Salud de Colombia, es seguro para el personal de laboratorio y el medio ambiente.
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Astronaut L. Gordon Cooper is assisted into his spacecraft for tests
1963-01-01
NASA and McDonnell Aircraft Corp. spacecraft technicians assist Astronaut L. Gordon Cooper into his spacecraft prior to undergoing tests in the altitude chamber. These tests are used to determine the operating characteristcs of the overall environmental control system.
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Inactivacion de virus ADN envueltos en la producción de hemoderivados (Albúmina e Inmunoglobulinas
Directory of Open Access Journals (Sweden)
Ignacio Juan Ruibal Brunet
1999-08-01
Full Text Available Se estudió la inactivación del virus herpes simple humano tipo 1 como modelo de virus ADN envueltos, durante las etapas de producción de las inmunoglobulinas intramuscular e intravenosa y la albúmina humana, las etapas del método de fraccionamiento alcohólico para la obtención de estos productos, así como los métodos de remoción y/o inactivación introducidos en el proceso de manufactura, pasteurización y cromatografía de intercambio iónico. El virus se cuantificó por efecto citopático. La obtención de valores de reducción acumulativos reportados en este trabajo demuestran que el método de fraccionamiento alcohólico utilizado en Cuba como variante del método de Cohn-Oncley, combinando métodos de inactivación/remoción, produce un nivel de inactivación de virus ADN envueltos que garantiza una alta seguridad biológica de estos productos para su uso en humanos.Inactivation of human herpes simplex virus I asa model of enveloped DNA virus was studied in the stages of production of intramuscular/ intravenous inmunoglobulins and human albumin, in the phases of alcohol fractionation for obtaining these products, and in the methods of removal and/or inactivation implemented in manufacture, pasteurization and ion - exchange chromatography. The virus was quantified by cytophatic effects. The cumulative reduction values reported in this paper proved that the use of alcohol fractionation in Cuba, as a variant of Cohn - Oncley method, combined with removal/inactivation procedures resulted in enveloped DNA virus inactivation assuring high biological safety for albumin and immunoglobulins for their use in human beings.
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Ionophorèse et électroporation : administration cutanée de médicaments et d'ADN
Préat, Véronique; Vandermeulen, Gaëlle; Daugimont, Liévin; Wascotte, Valentine
2009-01-01
La peau est une cible intéressante pour l'administration de médicaments et d'ADN qui cependant reste limitée par la faible perméabilité du stratum corneum. L'ionophorèse et l'électroporation ont été largement étudiées afin d'obtenir une administration transdermique. Dans les deux cas, le passage de courant perturbe la perméabilité de la peau et même la perméabilité cellulaire dans le cas précis de l'électroporation. Ces deux techniques permettent d'élargir le spectre des substances administra...
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Modelado molecular de la interacción de fármacos antitumorales y nucleasas con el ADN
Bueren Calabuig, Juan Antonio
2011-01-01
Premio Extraordinario de Doctorado de la UAH en 2013 Los métodos computacionales están convirtiéndose en herramientas muy importantes en ciertas áreas de la investigación como la caracterización de sitios de unión de ligandos a proteínas, acoplamiento de pequeñas moléculas en sitios de unión al ADN y proteínas y simulaciones de dinámica molecular. Los resultados obtenidos aportan información que, a veces, está más allá de las posibilidades puramente experimentales y pueden usarse para gui...
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Yherson Franchesco Molina Henao
2014-09-01
Full Text Available Rhinoclemmys nasuta (Testudines: Geoemydidae es considerada una especie casi endémica de Colombia y la más primitiva del género, sin embargo, se encuentra clasificada por la IUCN como deficiente de datos, ya que la información disponible no es suficiente para hacer una evaluación directa o indirecta de su riesgo de extinción. En este trabajo se describe la implementación del método para realizar la secuenciación de la región control del ADN mitocondrial de R. nasuta, con el propósito de generar herramientas técnicas para futuros estudios de evolutivos y de conservación. Se utilizó el método de desalamiento (Salting-out para extraer ADN a muestras sanguíneas procedentes de Isla Palma y Playa Chucheros (Bahía Málaga–Pacífico Colombiano y se utilizó una pareja de cebadores degenerados (reportada para Chrysemys picta Testudines: Emydidae para realizar la amplificación. Se obtuvieron fragmentos de 800pb siendo exitosa la reacción de secuenciación de los amplificados, y se estableció un porcentaje de homología mayor al 92 % entre las secuencias obtenidas y las secuencias de ADNmt de Sacalia quadriocellata (Testudines:Geoemydidae y Cuora aurocapitata (Testudines:Geoemydidae, depositadas en el GeneBank. Este resultado demuestra que el método descrito puede ser una herramienta útil para el estudio de las poblaciones de R. nasuta del Pacífico colombiano, lográndose una efectiva secuenciación de la región control del ADNmt de esta especie.
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Energy Technology Data Exchange (ETDEWEB)
Smith, C. L. [Department of Radiotherapeutics, University of Cambridge, Cambridge (United Kingdom)
1962-02-15
The effect of both a-particle and X-ray irradiation on the rate of DNA synthesis in mouse fibroblast and HeLa cells in tissue culture is described. Tritiated thymidine micro autoradiography was used to indicate the rate of synthesis in the single layer cultures used. The results of the experiments show that: (1) The fraction of cells in a culture synthesizing DNA is unaffected by {alpha}-particles and X-rays in the doses used in the experiment. (2) The effect of either type of radiation is to reduce the rate of synthesis of DNA of the irradiated cells in synthesis. (3) The effect of a given dose of either type of radiation is to reduce the rate of synthesis of all the cells to a constant fraction of what it was in the unirradiated cells. (4) The rate of DNA synthesis is reduced to 37% (1/e) by a dose of ca. 25 {alpha}/{mu}{sup 2} or an X-ray dose of 14000 rad for mouse fibroblast cultures. In Hela cell cultures a dose of ca. 90000 rad is needed to reduce the rate of DNA synthesis to 37% of the initial value. (5) The reduction in synthesis occurs not more than a half hour after irradiation and may be an immediate effect. From (4) above the target shape can be roughly calculated and if it is assumed to be cylindrical it appears to have dimensions ca. 16 A in one direction and 16 000 A in the other, i. e. a long thin thread with a MW of ca. 5 * 10{sup 7} in the case of the mouse fibroblast experiments. In the case of the Hela cell experiments the target volume gives a MW of ca. 10{sup 7}. The results are consistent with the view that the target may possibly be the DNA template (or maybe DNAP because of the high MW in one case). If the effects described reflect damage to the DNA (or DNAP) template during the exponential phase of synthesis then observations (1), (2) and (3) above follow as obvious correlatives. (author) [French] L'auteur expose l'effet de l'irradiation par les particules {alpha} et par les rayons X sur la vitesse de synthese de l'ADN au niveau du
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Sauld, Jill Pierpont
2017-01-01
Since the inception of associate degree nursing programs, professional nursing conversations and debate have grappled with reckoning differences between the associate degree in nursing (ADN) and the bachelor's degree in nursing (BSN). Research reporting better patient outcomes with more baccalaureate prepared nurses has been a driving force for…
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Martin del Puerto, Maria; Martinez Garcia, Felipe; Martin Clemente, Juan Pedro
2011-01-01
En el presente trabajo se ha analizado la diversidad existente en el ADN cloroplástico (ADNcp) de 16 poblaciones distribuidas a lo largo del Sistema Central. Para ello, se ha empleado la técnica de PCR-RFLP (amplificación de fragmentos específicos y posterior digestión con enzimas de restricción) sobre 38 regiones del ADNcp (Grivet et al., 2001).
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Simonet Pascal
2000-07-01
Full Text Available Les bactéries se caractérisent par leurs stratégies évolutives multiples incluant mutations ponctuelles, remaniements endogènes par déplacements de séquences d’insertion ou de transposons, délétions ou amplifications de larges régions d’ADN et acquisition de nouveaux gènes par transfert horizontal d’informations génétiques. Les récentes et toutes premières analyses conduites sur les données des quelques génomes bactériens totalement séquencés indiquent le rôle tout à fait fondamental qu’ont pu jouer les transferts latéraux de gènes dans l’évolution bactérienne [1-3]. Nombre de travaux sont aujourd’hui conduits afin d’élucider le rôle des trois mécanismes de transfert (conjugaison, transformation et transduction dans l’évolution et l’adaptation des bactéries aux conditions changeantes de leur environnement. En particulier, l’accroissement inquiétant de la proportion de germes résistants aux antibiotiques serait le fait de la dispersion de plasmides porteurs des gènes de résistance parmi la microflore pathogène ? Dans ces cisconstances, la question de savoir si les plantes transgéniques, très souvent pourvues de tels gènes, pourraient constituer un facteur aggravant la dissémination d’éléments menaçant potentiellement la santé humaine est donc totalement justifiée. Tout au long de l’évolution, la nature a cependant établi un certain nombre de filtres moléculaires afin de limiter les flux de gènes, notamment entre organismes phylétiquement très éloignés. La caractéristique des plantes transgéniques tient à ce que certains des gènes des transgènes, et en particulier ceux conférant la résistance aux antibiotiques, ont une origine procaryotique susceptible de leur permettre de contourner les barrières moléculaires. Cependant, d’autres facteurs environnementaux, biotiques et abiotiques vont intervenir pour favoriser ou au contraire limiter les échanges de g
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Pachajoa Londoño, Harry Mauricio; Osorio, Julio; Hurtado, Paula
2013-01-01
El papel Whatman FTA es una alternativa para transportar y almacenar diferentes tipos de muestras y optimizar el tiempo, espacio de almacenamiento y costos. Desde hace varios años se utiliza este método de forma rutinaria y muchos centros médicos almacenan muestras por periodos de tiempo prolongados. Objetivo: Determinar el efecto del tiempo de almacenamiento de muestras de sangre en papel Whatman sobre la concentración del ADN. Materiales y métodos: Se utilizaron 110 muestras de sangre perif...
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Gloria Griemberg; Nidia F. Ferrarotti; Graciela Svibel; Maria R. Ravelli; Néstor J. Taranto; Emilio L. Malchiodi; María C. Pizzimenti
2006-01-01
Los anticuerpos anti-ADN nativo pueden detectarse por inmunofluorescencia indirecta con Crithidia luciliae, observándose tinción fluorescente anular del kinetoplasto que contiene ADN de doble cadena. En algunos casos pueden observarse imágenes fluorescentes en flagelo, membrana y corpúsculo basal, consideradas atípicas. Como C. luciliae pertenece a la familia Trypanosomatidae, que incluye patógenos para el hombre como Trypanosoma cruzi y Leishmaniaspp., se consideró que las imágenes atípicas ...
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Neuropatía óptica hereditaria de Leber por mutación G11778A del ADN mitocondrial. Manejo de un caso
Barreda Gago, David; Gómez Ledesma, Isabel; Santiago Rodríguez, María de los Ángeles; Hernández Galilea, Emiliano
2016-01-01
La neuropatía óptica hereditaria de Leber es una enfermedad genética mitocondrial que típicamente produce ceguera bilateral en adultos jóvenes varones. Además de la mutación del ADN mitocondrial son necesarios otros factores genéticos y ambientales para el desarrollo de la enfermedad. En la actualidad no existe un tratamiento eficaz para la neuropatía óptica hereditaria de Leber, pero el consejo genético en portadores asintomáticos es importante. Presentamos el caso clínico de un paciente de ...
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Baroreflexes of the rat. IV. ADN-evoked responses at the NTS.
Tang, Xiaorui; Dworkin, Barry R
2007-12-01
In a long-term (7-21 days) neuromuscular blocked (NMB) rat preparation, using precise single-pulse aortic depressor nerve (ADN) stimulation and stable chronic evoked response (ER) recordings from the dorsal-medial solitary nucleus (dmNTS), two different response patterns were observed: continuous and discrete. For the continuous pattern, activity began approximately 3 ms after the stimulus and persisted for 45 ms; for the discrete pattern, two complexes were separated by a gap from approximately 17 to 25 ms. The early complex was probably transmitted via A-fibers: it had a low stimulus current threshold and an average conduction velocity (CV) of 0.58-5.5 m/s; the high threshold late (HTL) complex had a CV = 0.26-0.58 m/s. The average stimulus amplitude-ER magnitude transduction curves for the A and HTL complexes were sigmoidal. For individual rats, in the linear range, mean r2 = 0.96 +/- 0.03 for both complexes. The average stimulus amplitude vs. the systolic blood pressure change (delta sBP) transduction curve was also approximately linear; however, for individual rats, the relationship was not consistently reliable: mean r2 = 0.48 +/- 0.19. Approximately 90% of recording sites had respiratory, and 50% had cardiac synchronism. The NMB preparation is useful for studying central baroreflex mechanisms that operate on time scales of days or weeks, such as adaptation and other kinds of neural plasticity.
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El ADN de la marca. La concepción de sus valores intangibles en un contexto dialogado
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Jaime Alberto Orozco Toro
2012-01-01
Full Text Available Aún hoy, en plena sociedad del conocimiento, se tienen límites conceptuales en relación con aspectos tan fundamentales como la identidad, la imagen y la reputación de marca. Incluso donde mayores dificultades se presentan es en las posibilidades de evaluación y medición de cada uno de estos conceptos ligados con la reputación empresarial. Así, la marca, como el elemento fundamental de las empresas del presente siglo, se ve obligada a indagar nuevas formas de interpretar sus acciones estratégicas, con el único objetivo de continuar conformando la estructura de la marca, el ADN que la diferencia y que le permite contrastar sus resultados a partir de evaluaciones y mediciones fiables, en un contexto donde la transparencia, ante el alud de comunicación, se plantea casi como una exigencia.
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Karina Barboza Rojas
2012-08-01
Full Text Available En Costa Rica, la producción de ajo (Allium sativum es escasa y se limita principalmente a las regiones de Llano Grande de Cartago. Sin embargo, por el precio que tiene actualmente en el mercado, el ajo costarricense se vislumbra como una hortaliza que podría constituirse en un recurso valioso para los productores nacionales. Por lo anterior, en este artículo se presenta la caracterización mediante secuencias ribosomales de materiales de ajo provenientes Costa Rica y su comparación con ajo importado de China. El ADN se extrajo a partir de hojas de vitroplantas de ajo mantenidas en un congelador a -70°C, pulverizadas en un mortero. El ADN ribosomal se amplificó, purificó y secuenció. Se realizó el análisis bioinformático de las secuencias ribosomales. El BLASTn permitió determinar que los productos de PCR amplificados corresponden a la secuencia parcial de los genes 28S y 18S (sitios de unión de los cebadores y a la secuencia completa de la región ITS-1, 5.8S e ITS-2. Se encontró que todas las secuencias alinearon en casi un 100% con la accesión EU626375.1 publicada en la base de datos del GeneBank, correspondiente al clon Allium sativum voucher BF-ALL-037. En general, las secuencias mostraron ser muy conservadas. Los puntajes obtenidos del alineamiento realizado con ClustalW reflejaron una identidad del 97 al 99% entre las secuencias.El presente estudio es el primer reporte de este tipo que se realiza sobre ajo costarricense y generó información básica e indispensable para continuar con los estudios moleculares de este cultivo.
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Fredy Uber Rosales-Longo
2007-01-01
Full Text Available Diversidad genética de las poblaciones de ajo (Allium sativum L. cultivadas en Gua temala, definida por mar cado res de ADN. En Guatemala es escasa la in for ma ción sobre la diversidad genética de ajo. Los objetivos del estudio fueron: incidir en el mejoramiento de Allium sativum, so bre la base del conocimiento de su variabilidad genética, así mismo, establecer una colección in vi tro de la co lec ción de las poblaciones cultivadas en Guatemala. Los experimentos fueron realizados entre octubre de 2005 y marzo de 2006. La determinación de las variaciones de ADN se realizaron me dian te la téc ni ca de AFLP. La información se analiza por medio de análisis de componentes principales, análisis de coordenadas principales y análisis de conglomerados. Mediante la inspección de los pro duc tos de AFLP y análi sis estadísticos, se detectó una alta variabilidad genética entre los materiales vegetales colectados. Las muestras clasificadas co mo del ti po Chi leno, correspondieron a los tipos Criollo. Nueve bien diferenciados grupos genéticos se conformaron en un dendrograma y se con fir mó que la diversidad genética descubierta es una función del lugar don de se cul ti van las po bla cio nes de ajo. Se identificó una mayor diversidad genética entre las mues tras de ajo del ti po Crio llo que las que se tienen en tre los ma te ria les del ti po Chileno, como producto de la mayor dispersión espacial de los primeros. Los materiales genéticos de ajo se encuentran actualmente preservados en un Banco de Germoplasma in vi tro en la Uni dad de Bio tec no lo gía del IC TA.
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Pedro Jara-Seguel
2008-01-01
Full Text Available The nuclear DNA content (2C value was determined in the commercial fish Galaxias maculatus (Galaxiidae was determined by microdensitometry of erythrocyte nuclei after Feulgen staining; rainbow trout erythrocytes with a known 2C value were used as a standard. The 2C value of G. maculatus was 2.21 ± 0.12 pg and its C value was equivalent to 1.105 pg (1,082.9 Mbp. This C value is within the range recorded for other osmeriform species (0.62-3.2 pg. The average sperm head diameter of G. maculatus is lower than the average sperm head diameter of rainbow trout (used as a standard, which coincides with the differences observed in the nuclear DNA content of both species. This information increases the genome data available for G. maculatus and might be useful in future programs dealing with its genetic manipulation.El contenido de ADN nuclear (valor 2C fue determinado en el pez comercial Galaxias maculatus (Galaxiidae usando microdensitometría de núcleos de eritrocitos sometidos a tinción de Feulgen, utilizando como estándar eritrocitos de trucha arco iris con un valor 2C conocido. El valor 2C de G. maculatus fue 2,21 ± 0,12 pg y su valor C es equivalente a 1,105 pg (1.082,9 pMb. Este valor C está dentro del rango registrado para otras especies de osmeriformes (0,62-3,2 pg. El diámetro promedio de la cabeza del espermatozoide de G. maculatus es menor al promedio descrito para la trucha arco iris utilizado como estándar, lo que coincide con las diferencias observadas en el contenido de ADN nuclear entre ambas especies. Estos datos contribuyen a ampliar los antecedentes genómicos disponibles para G. maculatus y podrían ser útiles en futuros programas tendientes a su manipulación genética.
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Salas, Margarita; Mencía, Mario; Vega, Miguel de; Lázaro, José M.; Gella Montero, Pablo
2011-01-01
La presente invención se refiere a un método de amplificación de ADN basado en los orígenes de replicación del bacteriófago φ29, así como a las construcciones génicas, vectores y oligonucleótidos que pueden emplearse en dicho método para amplificar una secuencia exógena de interés.
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Hanson, Curt; Schaefer, Jacob; Burken, John J.; Larson, David; Johnson, Marcus
2014-01-01
Flight research has shown the effectiveness of adaptive flight controls for improving aircraft safety and performance in the presence of uncertainties. The National Aeronautics and Space Administration's (NASA)'s Integrated Resilient Aircraft Control (IRAC) project designed and conducted a series of flight experiments to study the impact of variations in adaptive controller design complexity on performance and handling qualities. A novel complexity metric was devised to compare the degrees of simplicity achieved in three variations of a model reference adaptive controller (MRAC) for NASA's F-18 (McDonnell Douglas, now The Boeing Company, Chicago, Illinois) Full-Scale Advanced Systems Testbed (Gen-2A) aircraft. The complexity measures of these controllers are also compared to that of an earlier MRAC design for NASA's Intelligent Flight Control System (IFCS) project and flown on a highly modified F-15 aircraft (McDonnell Douglas, now The Boeing Company, Chicago, Illinois). Pilot comments during the IRAC research flights pointed to the importance of workload on handling qualities ratings for failure and damage scenarios. Modifications to existing pilot aggressiveness and duty cycle metrics are presented and applied to the IRAC controllers. Finally, while adaptive controllers may alleviate the effects of failures or damage on an aircraft's handling qualities, they also have the potential to introduce annoying changes to the flight dynamics or to the operation of aircraft systems. A nuisance rating scale is presented for the categorization of nuisance side-effects of adaptive controllers.
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Marcela Díaz-Matallana
2012-01-01
Full Text Available El objetivo del presente trabajo fue el de deter-minar in vitro el haplogrupo de la región hipervariable I (HVR-I del ADN mitocondrial (ADNmt obtenido a partir de una muestra dental perteneciente a un individuo asociado a la comunidad de los Paracas, hallada por Jorge Reynolds en los años 60 del siglo XX en Ica (Perú. Gracias a esta tipificación molecular, hemos podido contribuir a la información arqueológica y antropológica ya registrada para esta población peruana de más de 2000 años de antigüedad, de-terminando su linaje materno y su vínculo con otros pobladores nativos americanos en la región.
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Uso del ADN forense en la Policía Nacional para identificación de alias “Édgar Tovar”
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Martha Liliana Acevedo Neira
2010-07-01
Full Text Available El análisis genético de fragmentos óseos tomados de un cuerpo en descomposición permitió confirmar la muerte de alias “Édgar Tovar”, comandante y responsable del narcotráfico del frente 48 de las Farc. El perfilgenético obtenido de los restos humanos fue comparado con la información del ADN nuclear y de cromosoma Y, del padre de Ángel Gabriel Lozada García,obteniendo una probabilidad estadística de paternidad de 99.991% y una coincidencia total en la información contenida en los marcadores de cromosomaY analizados, lo que sumado a labores investigativas de la Policía Nacional se consideró suficiente para determinar la identificación del cuerpo.
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Gleice Cristina Leite
2011-12-01
Full Text Available OBJECTIVE: To describe the analysis of geographical and temporal distribution of DNA profiles determined by pulsedfield gel electrophoresis (PFGE of methicillinresistant Staphylococcus aureus (MRSA strains isolated from hospitalized patients in a tertiary care university hospital in Brazil. METHODS: Ninetynine samples of MRSA obtained from 89 patients in the period 1999- 2004 were studied. MRSA strains were isolated from central venous catheters (33 isolates and bloodstream infections (66 strains. PFGE with 20 units of SmaI restriction endonuclease was used for genomic typing. RESULTS: Analysis of DNA PFGE of 99 strains of MRSA revealed 26 profiles and their respective related profiles. The mean time interval for detecting MRSA infection was 26 days from hospital admission. Forty-nine patients (57.6% had a recent hospitalization. The DNA PFGE MRSA profiles were distributed in three clonal groups-I, II, and III-according to the period of time when the MRSA strains were isolated. DNA PFGE MRSA profiles were spread homogeneously through all hospital wards. CONCLUSIONS: Changes in the distribution of DNA PFGE MRSA profiles were largely temporal, with clonal groups being replaced over time, without predominance in any hospital ward or any specific area of the hospital.OBJETIVO: Analizar la distribución geográfica y temporal de los perfiles de ADN determinados mediante electroforesis en gel de campo pulsado (PFGE de cepas de Staphylococcus aureus resistente a la meticilina (SARM aisladas de pacientes internados en un hospital universitario de atención terciaria en el Brasil. MÉTODOS: Se estudiaron 99 muestras de SARM obtenidas 89 de pacientes en el período 1999-2004. Las cepas de SARM se aislaron de infecciones de catéteres venosos centrales (33 aislados y del torrente sanguíneo (66 cepas. Para la tipificación genómica se empleó PFGE con 20 unidades de endonucleasa de restricción SmaI. RESULTADOS: El análisis del ADN de 99 cepas de SARM
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Alejandro Oceguera-Figueroa
2005-12-01
Full Text Available The phylogenetic relationships of the suborder Erpobdelliformes, a group of non-sanguivorous leeches, were investigated with the use of mitochondrial cytochrome c oxidase subunit I, mitochondrial 12S rDNA and nuclear 18S rDNA. The resulting hypothesis indicates that Erpobdellidae and Salifidae are monophyletic and each other closest relatives. We detect, for first time in leeches, intra-specific variation of similar amount than inter-specific variation. We formally resurrect the name Erpobdella mexicana, proposed by Dugès for Mexican specimens, and recommend the use of the name Erpobdella ochoterenai rather than Erpobdella microstoma for Mexican specimens. We record an invasive species of the family Salifidae: Barbronia arcana in Mexico, representing the first record of the species outside Australia, first record of the family in Mexico and third in the New World.Se estudian las relaciones filogenéticas del suborden Erpobdelliformes, un grupo de sanguijuelas no hematófagas de vertebrados, con base en secuencias de la subunidad I del citocromo c oxidasa del ADN mitocondrial, 12S ADNr del ADN mitocondrial y 18S ADNr del ADN nuclear. La hipótesis resultante señala que las familias Salifidae y Erpobdellidae son monofiléticas y hermanas entre sí. Se detecta por primera vez en sanguijuelas variación interespecífica de magnitud similar a la variación interespecífica. Formalmente se reslece el nombre empleado por Dugès: Erpobdella mexicana para las formas mexicanas, así como se argumenta sobre el uso del nombre Erpobdella ochoterenai en lugar de Erpobdella microstoma para las formas mexicanas. Se registra a una especie invasora de la familia Salifidae en México: Barbronia arcana, el cual constituye el primer registro de la especie fuera de Australia, primer registro de la familia en México y tercero en el continente americano.
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Oscar Andrés-Gamboa
2008-08-01
Full Text Available OBJECTIVE: To assess cost-effectiveness of conventional cytology and HPV DNA testing for cervical-cancer screening in Colombia. MATERIAL AND METHODS: The National Cancer Institute of Colombia (NCIC in 2007 developed a Markov model on the natural history of cervical cancer; no screening, conventional cytology, and HPV DNA testing were compared. Only direct costs were used. Outcomes comprise cervical cancer mortality, years of life saved, and lifetime costs. Discounted incremental cost-effectiveness ratios were estimated and sensitivity analyses were conducted for key parameters. RESULTS: Depending on the screening strategy a 69-81% mortality reduction might be expected. The HPV DNA testing every five years is a cost-effective strategy (Incremental Cost-Effectiveness Ratio (ICER: USD$44/YLS if the cost per test is under USD$31. The effectiveness was sensitive to coverage and primarily to follow-up. CONCLUSIONS: HPV DNA testing is a cost-effective alternative for screening in Colombia. Not only high coverage but high follow-up rates are critical for successful screening programs.OBJETIVO: evaluar el costo-efectividad de la citología convencional y la prueba de ADN-VPH para tamización de cáncer cervical en Colombia. MATERIAL Y MÉTODOS: el Instituto Nacional de Cancerología de Colombia construyó en 2007 un modelo de Markov de historia natural del cáncer cervical. Se comparó "no tamización", citología convencional y prueba de ADN-VPH. Se utilizaron costos directos. Los desenlaces fueron mortalidad, años de vida ganados y costos. Se calcularon razones de costo-efectividad incremental. Se realizaron análisis de sensibilidad para parámetros clave. RESULTADOS: la mortalidad se redujo 69-81% según la estrategia. La tamización con ADN-VPH cada cinco años es costo-efectiva (ICER (Razón de Costo-Efectividad incremental por sus siglas en inglés: 44 dólares por año de vida saludable si los costos por prueba son menores a 31 dólares. La
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Fuentes Corripio, Isabel de
1999-01-01
Se ha estudiado la aplicación de las técnicas moleculares en el diagnóstico por medio de la detección del ADN del parásito en diversos tipos de muestras procedentes de pacientes. La alta especificidad y sensibilidad obtenida con la PCR secuencial interna destacó en el diagnóstico de la toxoplasmosis. La sensibilidad se incrementa combinando el análisis de diferentes tipos de muestras y muestras secuenciales. Se realizó el estudio epidemiológico de la toxoplasmósis gestacional en el área de Ma...
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Meza, Giovanna; Ulloa, Juan Carlos; Uribe, Ana María; Gutiérrez, María Fernanda
2013-01-01
Los tejidos embebidos en parafina son muestras que reposan en los bancos de patología y almacenan importante información genética, útil para estudios retrospectivos de epidemiología y de patología molecular y para el diagnóstico de enfermedades en humanos y en animales. Dentro de las metodologías descritas para extraer ADN de tejidos en parafina, pocas resultan exitosas a la hora de obtener un material genético, con la cual se pueda amplificar fragmentos superiores a 200pb, por la técnica de ...
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1992-01-01
Technology originating in a NASA-sponsored study of the measurement of microbial growth in zero gravity led to the development of Biomerieux Vitek, Inc.'s VITEK system. VITEK provides a physician with accurate diagnostic information and identifies the most effective medication. Test cards are employed to identify organisms and determine susceptibility to antibiotics. A photo-optical scanner scans the card and monitors changes in the growth of cells contained within the card. There are two configurations - VITEK and VITEK JR as well as VIDAS, a companion system that detects bacteria, viruses, etc. from patient specimens. The company was originally created by McDonnell Douglas, the NASA contractor.
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I. Roncancio-Sánchez
2006-06-01
Full Text Available La producción de combustibles, solventes y algunos productos químicos a partir de sustratos celulósicos usando microorganismos ofrece una ventaja frente a los de origen fósil. Un acercamiento prometedor ha sido la implementación de ingeniería genética utilizando genes de enzimas involucradas en la degradación de desechos celulósicos. En la última década se han generado bibliotecas genéticas para proveer enzimas celulolíticas, que hagan el proceso más rentable, lo cual permitiría aprovechar mejor residuos celulósicos disponibles. Este trabajo describe el aislamiento de dos fragmentos de ADN que expresan actividad endo-β-1,4-glucanasa, a partir de un segmento ADN de 13Kb (clon 02080-25 aislado de una biblioteca genómica de la cepa nativa Clostridium sp IBUN22A. El aislamiento de la región codificadora se realizó a través de pruebas de inducción de la actividad, análisis por restricción del segmento y de una sub-biblioteca con la enzima Sau3A I. 325 clones fueron obtenidos, de los cuales 271 tenían inserto. El tamizaje molecular de estos últimos mostró que siete clones presentaron tamaños entre 3500pb y 7000pb y el tamizaje enzimático con carboximetilcelulosa como sustrato permitió el aislamiento de los clones pBSh-37 y pBSh-26 con la actividad endo-β-1,4-glucanasa original, de tamaños de inserto de 627pb y 879pb respectivamente. Este trabajo es el punto de partida para el aislamiento de enzimas de alto potencial biotecnológico.
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Energy Technology Data Exchange (ETDEWEB)
Tshitenge, G. [Centre nucléaire TRICO, Kinshasa (Congo, The Democratic Republic of the); Ledoux, L. [Centre d’étude de l' énergie nucléaire Mol (Belgium)
1970-01-15
Barley grains, after germinating for 11 hours in the presence of water, were cut into sections at the end opposite the embryo. They were incubated in solutions of {sup 3}H-DNA, {sup 13I}I-ribonuclease, and {sup 3}H-DNA {sup 131}I-ribonuclease complex for three hours. They were then placed in a water-saturated atmosphere for 24 hours. At this stage the different organs of the seedlings were separated and homogenized in a solution containing 0.15M sodium chloride and 0.1 M sodium ethylenediaminetetraacetate at pH 7. By measuring the radioactivity found in the homogenates one can estimate the penetration of the macromolecules under study. The results show that the quantity found varies from one case to the other and depends both on the nature of the macromolecule and of the organ studied. (author) [French] Des orges qui ont germé pendant 11 h en présence d’eau sont sectionnées au bout opposé à l’embryon. Elles sont incubées avec des solutions d’ADN{sup 3}H, de RNase{sup 131}1 et de complexe ADN{sup 3}H - RNase {sup 131}I, pendant 3 h. Elles sont ensuite placées dans une atmosphère saturée d'eau pendant 24 h. A ce moment, les différents organes des plantules sont séparés et homogénéisés en présence d'une solution 0,15M en NaCl et 0,1M en éthylènediamine-tétracétate de Na à pH 7. La mesure de la radioactivité retrouvée dans les homogénats permet d'évaluer la pénétration des macromolécules considérées. Les résultats montrent que la quantité retrouvée varie d'un cas â l'autre et dépend à la fois de la nature de la macromolécule et de l'organe considéré. (author)
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1980-01-01
Burns & McDonnell Engineering's environmental control study is assisted by NASA's Computer Software Management and Information Center's programs in environmental analyses. Company is engaged primarily in design of such facilities as electrical utilities, industrial plants, wastewater treatment systems, dams and reservoirs and aviation installations. Company also conducts environmental engineering analyses and advises clients as to the environmental considerations of a particular construction project. Company makes use of many COSMIC computer programs which have allowed substantial savings.
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Kogan, Alexander E; Filatov, Vladimir L; Kolosova, Olga V; Katrukha, Ivan A; Mironova, Ekaterina V; Zhuravleva, Natalya S; Nagibin, Oleg A; Kara, Andrei N; Bereznikova, Anastasiya V; Katrukha, Alexey G
2013-01-01
Adiponectin (Adn) is a protein that circulates in the blood in several oligomeric forms, namely low-, medium-, and high-molecular-weight forms. Adn may serve as a risk factor for type 2 diabetes mellitus (T2DM). The aims of this work were (1) to produce monoclonal antibodies (MAbs) specific to different Adn oligomeric forms, (2) to design immunoassays suitable for measuring the Adn forms present in human blood, and (3) to investigate the changes in Adn forms that occur in patients with T2DM. Gel filtration, fluoroimmunoassays, and Western blotting were utilized as major techniques in this study. MAbs recognizing various oligomeric forms of Adn were obtained. Complexes between Adn and complement component C1q and between the low molecular weight form of Adn and albumin were described in human blood. A decrease in the total Adn and Adn-albumin complex levels in the blood of patients with T2DM and no difference in the levels of the Adn-C1q complex in comparison with healthy volunteers were demonstrated. An Adn94-Adn63 fluoroimmunoassay was selected as the technique that most accurately measured the mass ratio of Adn oligomers in blood samples, and an Adn214-Adn27 assay that measured the low-molecular-weight form of Adn only.
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Directory of Open Access Journals (Sweden)
Jorge Fraga
2005-10-01
Full Text Available Random amplified polymorphic DNA (RAPD technique is a simple and reliable method to detect DNA polymorphism. Several factors can affect the amplification profiles, thereby causing false bands and non-reproducibility of assay. In this study, we analyzed the effect of changing the concentration of primer, magnesium chloride, template DNA and Taq DNA polymerase with the objective of determining their optimum concentration for the standardization of RAPD technique for genetic studies of Cuban Triatominae. Reproducible amplification patterns were obtained using 5 pmoL of primer, 2.5 mM of MgCl2, 25 ng of template DNA and 2 U of Taq DNA polymerase in 25 µL of the reaction. A panel of five random primers was used to evaluate the genetic variability of T. flavida. Three of these (OPA-1, OPA-2 and OPA-4 generated reproducible and distinguishable fingerprinting patterns of Triatominae. Numerical analysis of 52 RAPD amplified bands generated for all five primers was carried out with unweighted pair group method analysis (UPGMA. Jaccard's Similarity Coefficient data were used to construct a dendrogram. Two groups could be distinguished by RAPD data and these groups coincided with geographic origin, i.e. the populations captured in areas from east and west of Guanahacabibes, Pinar del Río. T. flavida present low interpopulation variability that could result in greater susceptibility to pesticides in control programs. The RAPD protocol and the selected primers are useful for molecular characterization of Cuban Triatominae.La técnica de ADN polimórfico amplificado al azar (RAPD es un método simple para detectar el polimorfismo genético del ADN. Diferentes factores afectan los perfiles de amplificación lo que se manifiesta en la presencia de bandas falsas y en la reproducibilidad del ensayo. En nuestro trabajo analizamos los cambios de la concentración de cebador, ADN molde, cloruro de magnesio y de Taq ADN polimerasa con el objetivo de determinar su
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Directory of Open Access Journals (Sweden)
Ana María García Cepero
2006-12-01
Full Text Available Uno de los mayores inconvenientes en la extracción y purificación de biomoléculas a partir de plantas del género Coffea, es un alto contenido de polifenoles y compuestos tánicos. En el presente artículo se describe una metodología que permite obtener ADN de alta pureza. La extracción del ADN del homogeneizado de tejido foliar en siete genotipos de Coffea sp., se realizó mediante la técnica citada por Chaparro (1993 y su purificación se logró mediante cromatografía de exclusión molecular sobre una fase estacionaria de Sephacryl S-1000. Los resultados muestran que la alta eficiencia de separación de ARN degradado, proteínas, pigmentos y compuestos que absorben entre 220 y 300 nm, permiten obtener un ADN de alta pureza a juzgar por los datos espectrofotométricos y electroforéticos.One of the greatest difficulties in extracting and purifying biomolecules from plants in the genus Coffea is the high polyphenol and tannin contents. In this study a methodology is described that allows obtaining high purity DNA from leaf tissues of seven genotypes of Coffea sp. by means of the technique desribed by Chaparro (1993 and its further purification was achieved by molecular exclusion chromatography on Sephacryl S-1000 (Pharmacia. The results showed that the high separation efficiency of degraded RNA, proteins, pigments, and other compounds that absorb between 220 and 300 nm allowed obtaining high purity DNA as judged by the spectophometric and electroforetic data.
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National Aeronautics and Space Administration — The NASA Thesaurus contains the authorized NASA subject terms used to index and retrieve materials in the NASA Technical Reports Server (NTRS) and the NTRS...
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Yoshida, Tomohide; Nagasaki, Hiraku; Asato, Yoshihide; Ohta, Takao
2009-05-01
Adiponectin consists of three subspecies (high-, middle- and low-molecular weight adiponectin). Among these, high-molecular weight adiponectin (H-adn) is suggested to be an active form of this protein. To assess the relationship between H-adn and postnatal growth in preterm infants (PIs), serum H-adn and total adiponectin (T-adn) were measured in 46 PIs at birth and at corrected term, and 26 term infants (TI) at birth. T-adn and H-adn concentrations, and the ratio of H-adn to T-adn (H/T-adn) were significantly greater in TI and PI at corrected term than in PI at birth (p adn and H-adn concentrations in PI at corrected term were similar to those in TI, but H/T-adn in PI at corrected term was less than that in TI (p adn and serum concentrations of T- and H-adn in PI at corrected term were different from those in TI. These data suggest that quality of early postnatal growth in PIs is different from that in normally developed TI. Postnatal growth accompanying adipose tissue similar to TI may be important for PI to prevent future development of cardiovascular disease.
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Yoshida, Tomohide; Nagasaki, Hiraku; Asato, Yoshihide; Ohta, Takao
2011-12-01
Extra-uterine growth retardation (EUGR) is associated with an increased risk for cardiometabolic diseases later in life. The aim of the present study was to examine the relationship between early weight change after birth in preterm infants and adiponectin (adn) multimeric complexes. Subjects included 28 preterm infants born between weeks 24 and 33 of gestation. Serum adn multimeric complexes and the anthropometric parameters were measured in preterm infants at birth and at corrected term. Bodyweight (BW) decreased during the first week of life, with birthweight restored at approximately 19 days after birth. Nineteen of the subjects had EUGR at corrected term. Total (T)-adn, high-molecular-weight (H)-adn, and the ratio of H-adn to T-adn (H/T-adn) were significantly elevated at corrected term than at birth. Postmenstrual age, birthweight, birth length and lowest BW after birth were positively correlated with H-adn and H/T-adn. Weight reduction after birth was negatively correlated with H-adn. Age to restore birthweight was negatively correlated with T-adn, H-adn and H/T-adn. Stepwise multiple regression analysis indicated age to restore birthweight as the major predictor of T-adn and H-adn. Early weight changes after birth may alter serum adn level in preterm infants at corrected term. The appropriate nutritional support in the early postnatal period could reduce the prevalence of EUGR and the future risk for cardiometabolic diseases. © 2011 The Authors. Pediatrics International © 2011 Japan Pediatric Society.
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NASA Astrophysics Technology Needs
Stahl, H. Philip
2012-01-01
July 2010, NASA Office of Chief Technologist (OCT) initiated an activity to create and maintain a NASA integrated roadmap for 15 key technology areas which recommend an overall technology investment strategy and prioritize NASA?s technology programs to meet NASA?s strategic goals. Science Instruments, Observatories and Sensor Systems(SIOSS) roadmap addresses technology needs to achieve NASA?s highest priority objectives -- not only for the Science Mission Directorate (SMD), but for all of NASA.
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Antígona y su biobanco de ADN: Desaparecidos, búsqueda y tecnologías forenses en México
Directory of Open Access Journals (Sweden)
Ernesto Schwartz Marin
2018-03-01
Full Text Available La tragedia de Antígona ha sido apropiada estética y políticamente por artistas y activistas en México para discutir la búsqueda de personas desaparecidas. Reflexionando sobre las relaciones entre la futilidad, las tecnologías forenses y la noción de un sujeto político-victima, este ensayo aborda las historias de las familias e individuos que constituyeron el órgano de gobierno del proyecto ‘Ciencia Forense Ciudadana’. Este proyecto diseñó la primera base de datos forense de ADN creada y administrada por familiares de desaparecidos en México. Esta investigación es producto de años de trabajo etnográfico y de investigación participativa realizada en la Ciudad de México. A través de este acercamiento teórico/metodológico, argumentamos que es sólo cuando las tecnologías forenses no están gobernadas por principios de eficiencia, lógicas del mercado o pericia exclusiva, que se pueden transgredir los viejos tropos del humanitarismo forense, y por lo tanto abrir nuevas relaciones entre ciencia, justicia y verdad.
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1994-01-01
The NASA Strategic Plan is a living document. It provides far-reaching goals and objectives to create stability for NASA's efforts. The Plan presents NASA's top-level strategy: it articulates what NASA does and for whom; it differentiates between ends and means; it states where NASA is going and what NASA intends to do to get there. This Plan is not a budget document, nor does it present priorities for current or future programs. Rather, it establishes a framework for shaping NASA's activities and developing a balanced set of priorities across the Agency. Such priorities will then be reflected in the NASA budget. The document includes vision, mission, and goals; external environment; conceptual framework; strategic enterprises (Mission to Planet Earth, aeronautics, human exploration and development of space, scientific research, space technology, and synergy); strategic functions (transportation to space, space communications, human resources, and physical resources); values and operating principles; implementing strategy; and senior management team concurrence.
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MD-11 PCA - First Landing at Edwards
1995-01-01
This McDonnell Douglas MD-11 approaches the first landing ever of a transport aircraft under engine power only on Aug. 29, 1995, at NASA's Dryden Flight Research Center, Edwards, California. The milestone flight, flown by NASA research pilot and former astronaut Gordon Fullerton, was part of a NASA project to develop a computer-assisted engine control system that enables a pilot to land a plane safely when it normal control surfaces are disabled. The Propulsion-Controlled Aircraft (PCA) system uses standard autopilot controls already present in the cockpit, together with the new programming in the aircraft's flight control computers. The PCA concept is simple--for pitch control, the program increases thrust to climb and reduces thrust to descend. To turn right, the autopilot increases the left engine thrust while decreasing the right engine thrust. The initial Propulsion-Controlled Aircraft studies by NASA were carried out at Dryden with a modified twin-engine F-15 research aircraft.
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Kennedy, Thomas L.
1956-01-01
A flight investigation was conducted to determine the effect of jet exhaust on the drag, trim characteristics, and afterbody pressures on a 0.125-scale rocket model of the McDonnell F-101A airplance. Power-off data were obtained over a Mach number range of 1.04 to 1.9 and power-on data were obtained at a Mach number of about 1.5. The data indicated that with power-on the change in external drag coefficient was within the data accuracy and there was a decrease in trim angle of attack of 1.27 degrees with a corresponding decrease of 0.07 in lift coefficient. Correspondingly, pressure coefficients on the side and bottom of the fuselage indicated a positive increment near the jet exit. As the distance downstream of the jet exit increased, the increment on the bottom of the fuselage increased, whereas the increments on the side decreased to a negative peak.
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Internal NASA Study: NASAs Protoflight Research Initiative
Coan, Mary R.; Hirshorn, Steven R.; Moreland, Robert
2015-01-01
The NASA Protoflight Research Initiative is an internal NASA study conducted within the Office of the Chief Engineer to better understand the use of Protoflight within NASA. Extensive literature reviews and interviews with key NASA members with experience in both robotic and human spaceflight missions has resulted in three main conclusions and two observations. The first conclusion is that NASA's Protoflight method is not considered to be "prescriptive." The current policies and guidance allows each Program/Project to tailor the Protoflight approach to better meet their needs, goals and objectives. Second, Risk Management plays a key role in implementation of the Protoflight approach. Any deviations from full qualification will be based on the level of acceptable risk with guidance found in NPR 8705.4. Finally, over the past decade (2004 - 2014) only 6% of NASA's Protoflight missions and 6% of NASA's Full qualification missions experienced a publicly disclosed mission failure. In other words, the data indicates that the Protoflight approach, in and of it itself, does not increase the mission risk of in-flight failure. The first observation is that it would be beneficial to document the decision making process on the implementation and use of Protoflight. The second observation is that If a Project/Program chooses to use the Protoflight approach with relevant heritage, it is extremely important that the Program/Project Manager ensures that the current project's requirements falls within the heritage design, component, instrument and/or subsystem's requirements for both the planned and operational use, and that the documentation of the relevant heritage is comprehensive, sufficient and the decision well documented. To further benefit/inform this study, a recommendation to perform a deep dive into 30 missions with accessible data on their testing/verification methodology and decision process to research the differences between Protoflight and Full Qualification
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The NASA Severe Thunderstorm Observations and Regional Modeling (NASA STORM) Project
Schultz, Christopher J.; Gatlin, Patrick N.; Lang, Timothy J.; Srikishen, Jayanthi; Case, Jonathan L.; Molthan, Andrew L.; Zavodsky, Bradley T.; Bailey, Jeffrey; Blakeslee, Richard J.; Jedlovec, Gary J.
2016-01-01
The NASA Severe Storm Thunderstorm Observations and Regional Modeling(NASA STORM) project enhanced NASA’s severe weather research capabilities, building upon existing Earth Science expertise at NASA Marshall Space Flight Center (MSFC). During this project, MSFC extended NASA’s ground-based lightning detection capacity to include a readily deployable lightning mapping array (LMA). NASA STORM also enabled NASA’s Short-term Prediction and Research Transition (SPoRT) to add convection allowing ensemble modeling to its portfolio of regional numerical weather prediction (NWP) capabilities. As a part of NASA STORM, MSFC developed new open-source capabilities for analyzing and displaying weather radar observations integrated from both research and operational networks. These accomplishments enabled by NASA STORM are a step towards enhancing NASA’s capabilities for studying severe weather and positions them for any future NASA related severe storm field campaigns.
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Energy Technology Data Exchange (ETDEWEB)
Bond, V. P.; Feinendegen, L. E.; Cronkite, E. P. [Medical Research Centre, Brookhaven National Laboratory, Upton, Long Island, NY (United States)
1962-02-15
DNA and RNA metabolism was studied using tritiated thymidine (H{sup 3}Th), a specific precursor for DNA, and tritiated cytidine (H{sup 3}C), a common precursor for both RNA and DNA. With H{sup 3}C, differential incorporation into RNA, DNA or the soluble pool was determined autoradiographically in the single cell, and/or chemically for cell populations by means of differential extraction using appropriate treatment with perchloric acid. Initial turnover studies in the Hela cell with H{sup 3}C indicated the precursor role of nuclear RNA for cytoplasmic RNA. Conservation and distribution of label in the RNA fraction was consistent with major macromolecular RNA stability, and continued incorporation of label into the DNA fraction was consistent with the presence of a late precursor for DNA. Similar findings were observed in the immature bone marrow cells of the rat studied over a period of several days after intravenous administration of H{sup 3}C. The amount of tritium activity in the acid-soluble' RNA and DNA fractions was followed chemically and/or autoradiographically. The three curves were found to be parallel from the first day after injection and parallel to curves for tritium label in DNA following H{sup 3}Th administration. The expected rate of fall off in label, calculated from kinetics of the rat bone marrow cell populations studied separately by H{sup 3}Th and autoradiography, assuming no turnover of RNA or DNA and loss of label only by loss of marrow cells by division and maturation, was in agreement with the slopes obtained. The results indicate that, once synthesized, soluble and macromolecular RNA is retained by the bone marrow cell in a manner similar to DNA. Newly formed RNA and DNA are diluted in the cells only through cell division. (author) [French] Les auteurs ont etudie le metabolisme de l'ADN et de l'ARN a l'aide de thymidine tritiee (Th-{sup 3}H), precurseur specifique de l'ADN, et de cytidine tritiee (Cy-{sup 3}H), precurseur a la fois de l
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Bouffard, Frédérick
2015-01-01
Tableau d’honneur de la Faculté des études supérieures et postdoctorales, 2015-2016 Divers évènements d’épissage alternatif ont été identifiés pour certains gènes de la famille FANC, notamment pour FANCE. La voie de réparation de l’ADN FANC-BRCA nécessite l’intégrité de l’ensemble des protéines Fanconi afin d’assurer l’efficacité de la réparation des pontages inter-brins. Nous avons alors étudié l’impact de l’expression du variant d’épissage alternatif FANCE∆4 au niveau de la voie FANC-BRC...
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Disseminating NASA-based science through NASA's Universe of Learning: Girls STEAM Ahead
Marcucci, E.; Meinke, B. K.; Smith, D. A.; Ryer, H.; Slivinski, C.; Kenney, J.; Arcand, K.; Cominsky, L.
2017-12-01
The Girls STEAM Ahead with NASA (GSAWN) initiative partners the NASA's Universe of Learning (UoL) resources with public libraries to provide NASA-themed activities for girls and their families. The program expands upon the legacy program, NASA Science4Girls and Their Families, in celebration of National Women's History Month. Program resources include hands-on activities for engaging girls, such as coding experiences and use of remote telescopes, complementary exhibits, and professional development for library partner staff. The science-institute-embedded partners in NASA's UoL are uniquely poised to foster collaboration between scientists with content expertise and educators with pedagogy expertise. The thematic topics related to NASA Astrophysics enable audiences to experience the full range of NASA scientific and technical disciplines and the different career skills each requires. For example, an activity may focus on understanding exoplanets, methods of their detection, and characteristics that can be determined remotely. The events focus on engaging underserved and underrepresented audiences in Science, Technology, Engineering, and Mathematics (STEM) via use of research-based best practices, collaborations with libraries, partnerships with local and national organizations (e.g. National Girls Collaborative Project or NGCP), and remote engagement of audiences. NASA's UoL collaborated with another NASA STEM Activation partner, NASA@ My Library, to announce GSAWN to their extensive STAR_Net network of libraries. This partnership between NASA SMD-funded Science learning and literacy teams has included NASA@ My Library hosting a professional development webinar featuring a GSAWN activity, a newsletter and blog post about the program, and plans for future exhibit development. This presentation will provide an overview of the program's progress to engage girls and their families through the development and dissemination of NASA-based science programming.
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Zebulum, Ricardo S.
2011-01-01
NASA's scientists are enjoying unprecedented access to astronomy data from space, both from missions launched and operated only by NASA, as well as missions led by other space agencies to which NASA contributed instruments or technology. This paper describes the NASA astrophysics program for the next decade, including NASA's response to the ASTRO2010 Decadal Survey.
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NASA systems engineering handbook
Shishko, Robert; Aster, Robert; Chamberlain, Robert G.; McDuffee, Patrick; Pieniazek, Les; Rowell, Tom; Bain, Beth; Cox, Renee I.; Mooz, Harold; Polaski, Lou
1995-06-01
This handbook brings the fundamental concepts and techniques of systems engineering to NASA personnel in a way that recognizes the nature of NASA systems and environment. It is intended to accompany formal NASA training courses on systems engineering and project management when appropriate, and is designed to be a top-level overview. The concepts were drawn from NASA field center handbooks, NMI's/NHB's, the work of the NASA-wide Systems Engineering Working Group and the Systems Engineering Process Improvement Task team, several non-NASA textbooks and guides, and material from independent systems engineering courses taught to NASA personnel. Five core chapters cover systems engineering fundamentals, the NASA Project Cycle, management issues in systems engineering, systems analysis and modeling, and specialty engineering integration. It is not intended as a directive.
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Zhou, Fengwu; Cui, Jian; Zhou, Jing; Yang, John; Li, Yong; Leng, Qiangmei; Wang, Yangqing; He, Dongyi; Song, Liyan; Gao, Min; Zeng, Jun; Chan, Andy
2018-03-27
Atmospheric deposition nitrogen (ADN) increases the N content in soil and subsequently impacts microbial activity of soil. However, the effects of ADN on paddy soil microbial activity have not been well characterized. In this study, we studied how red paddy soil microbial activity responses to different contents of ADN through a 10-months ADN simulation on well managed pot experiments. Results showed that all tested contents of ADN fluxes (27, 55, and 82kgNha -1 when its ratio of NH 4 + /NO 3 - -N (R N ) was 2:1) enhanced the soil enzyme activity and microbial biomass carbon and nitrogen and 27kgNha -1 ADN had maximum effects while comparing with the fertilizer treatment. Generally, increasing of both ADN flux and R N (1:2, 1:1 and 2:1 with the ADN flux of 55kgNha -1 ) had similar reduced effects on microbial activity. Furthermore, both ADN flux and R N significantly reduced soil bacterial alpha diversity (pADN flux and R N were the main drivers in shaping paddy soil bacteria community. Overall, the results have indicated that increasing ADN flux and ammonium reduced soil microbial activity and changed the soil bacterial community. The finding highlights how paddy soil microbial community response to ADN and provides information for N management in paddy soil. Copyright © 2018 Elsevier B.V. All rights reserved.
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Energy Technology Data Exchange (ETDEWEB)
Tshitenge, G. [Centre nucléaire TRICO, Kinshasa (Congo, The Democratic Republic of the); Ledoux, L. [Centre d’étude de l' énergie nucléaire Mol (Belgium)
1970-01-15
Bacterial DNA, both radioactive and non-radioactive, and pancreatic ribonuclease labelled with iodine-131 are mixed together at a high ion strength and neutral pH. They are then dialysed against 0.009M sodium chloride. During dialysis a precipitate is formed, which is then separated with a centrifuge and redissolved at a neutral pH in a 0.1M phosphate buffer solution, or in 0.15M sodium chloride and 0.015M sodium citrate solution adjusted to pH 7. This solution is then analysed: (1) by DEAE-cellulose paper chromatography using a centrifuge; (2) by sedimentation of caesium chloride along a gradient; (3) by electrophoresis in agar gel. The results obtained show that a stable complex is formed between the DNA and ribonuclease. The properties of this complex are such that it can be compared with natural nucleoproteins. (author) [French] Des ADN bactériens radioactifs ou non et de la ribonucléase pancréatique marquée a l'iode-131 sont mélangés, à force ionique élevée et à pH neutre. Ils sont ensuite dialyses contre du NaCl 0.009M. Au cours de cette dialyse, un précipité se forme. Ce précipité est séparé par centrifugation et redissous à pH neutre dans du tampon phosphate 0,1M, ou dans une solution 0.015M en citrate de Na et 0,15M en NaCl ajustée à pH 7. Cette solution a été analysée: 1) par Chromatographie centrifugée sur pulpe de papier de DEAE- cellulose; 2) par sédimentation en gradient de CsCl; 3) par électrophorèse en gel d'agar. Les résultats obtenus montrent qu'un complexe stable sfest formé entre l'ADN et la RNase. Les propriétés de ce complexe permettent de le comparer aux nucléoprotéines naturelles. (author)
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Daño del ADN en trabajadoras bananeras expuestas a plaguicidas en Limón, Costa Rica
Directory of Open Access Journals (Sweden)
Vanessa Ramírez
2002-06-01
Full Text Available El uso de plaguicidas en los países en desarrollo es extenso en cantidad y en tiempo. Un gran porcentaje de lo que se aplica queda en el entorno y en los organismos que ahí habitan, lo que acarrea problemas de contaminación ambiental y deterioro de la salud de las personas que están en contacto con ellos. Los efectos se pueden manifestar a corto o a largo plazo y los síntomas varían desde un dolor de cabeza hasta el desarrollo de cáncer. La mayoría de los estudios en esta área se han orientado hacia los efectos agudos o crónicos y recientemente se inicia el estudio del efecto genotóxico de los plaguicidas. En e1 presente trabajo se evaluó el efecto genotóxico de los plaguicidas utilizados en las empacadoras de banano, usando como marcador biológico la electroforesis de células únicas (conocido como ensayo cometa en linfocitos aislados de sangre periférica. La población en estudio correspondió a 30 trabajadoras expuestas a plaguicidas, procedentes de 15 fincas bananeras y 28 mujeres sin antecedentes de exposición ocupacional a plaguicidas, de la misma área geográfica. Las trabajadoras que tenían entre cinco y quince años de trabajo presentaron mayor daño en la hebra sencilla del ADN (R² =0.12. Se desconoce si este efecto se debe a los plaguicidas que se utilizan actualmente o a plaguicidas empleados en el pasado. Tampoco fue posible correlacionar las dosis y las frecuencias de exposición a los plaguicidas con el daño al ADN, debido a que no existe un registro histórico sobre los productos empleados en el cultivo de banano, no se sabe por cuánto tiempo y las épocas en que fueron utilizados. Se recomienda el ensayo cometa para monitoreo genético en poblaciones expuestas a plaguicidasPesticide use in Costa Rica is very high and all year round. A high percentage of what is sprayed remains in the environment and in the living organisms around. This situation brings contamination and health problems to people in contact
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Directory of Open Access Journals (Sweden)
Hiroshi Yamamoto
Full Text Available BACKGROUND AND PURPOSE: Infections are important causes of postoperative morbidity after gastric surgery; currently, no factors have been identified that can predict postoperative infection. Adiponectin (ADN mediates energy metabolism and functions as an immunomodulator. Perioperative ADN levels and perioperative immune functioning could be mutually related. Here we evaluated a potential biological marker to reliably predict the incidence of postoperative infections to prevent such comorbidities. METHODS: We analyzed 150 consecutive patients who underwent elective gastric cancer surgery at the Shiga University of Medical Science Hospital (Shiga, Japan from 1997 to 2009; of these, most surgeries (n = 100 were performed 2008 onwards. The patient characteristics and surgery-related factors between two groups (with and without infection were compared by the paired t-test and χ(2 test, including preoperative ADN levels, postoperative day 1 ADN levels, and ADN ratio (postoperative ADN levels/preoperative ADN levels as baseline factors. Logistic regression analysis was performed to access the independent association between ADN ratio and postoperative infection. Finally, receiver operating curves (ROCs were constructed to examine its clinical utility. RESULTS: Sixty patients (40% experienced postoperative infections. The baseline values of age, American Society of Anesthesiologists physical status, total operating time, blood loss, surgical procedure, C-reactive protein (CRP levels, preoperative ADN levels, and ADN ratio were significantly different between groups. Logistic regression analysis using these factors indicated that type 2 diabetes mellitus (T2DM and ADN ratio were significantly independent variables (*p<0.05, ** p<0.01, respectively. ROC analysis revealed that the useful cutoff values (sensitivity/specificity for preoperative ADN levels, ADN ratio, blood loss, operating time, and CRP levels were 8.81(0.567/0.568, 0.76 (0
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Obrien, John E.; Fisk, Lennard A.; Aldrich, Arnold A.; Utsman, Thomas E.; Griffin, Michael D.; Cohen, Aaron
1992-01-01
Activities and National Aeronautics and Space Administration (NASA) programs, both ongoing and planned, are described by NASA administrative personnel from the offices of Space Science and Applications, Space Systems Development, Space Flight, Exploration, and from the Johnson Space Center. NASA's multi-year strategic plan, called Vision 21, is also discussed. It proposes to use the unique perspective of space to better understand Earth. Among the NASA programs mentioned are the Magellan to Venus and Galileo to Jupiter spacecraft, the Cosmic Background Explorer, Pegsat (the first Pegasus payload), Hubble, the Joint U.S./German ROSAT X-ray Mission, Ulysses to Jupiter and over the sun, the Astro-Spacelab Mission, and the Gamma Ray Observatory. Copies of viewgraphs that illustrate some of these missions, and others, are provided. Also discussed were life science research plans, economic factors as they relate to space missions, and the outlook for international cooperation.
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Cañar Serna, Dubert Yamil; Vallejo Cabrera, Franco Alirio; Muñoz Florez, Jaime Eduardo
2014-01-01
En Colombia, Cucurbita moschata es la especie domesticada de mayor importancia por su área de siembra, producción, versatilidad y consumo directo (Vallejo y Estrada, 2004). Como método de conservación, los bancos de ADN en plantas son el equivalente a las bibliotecas que contienen colecciones de alícuotas vegetales viables, con el propósito de mantener vivo este material y preservar sus características para el beneficio futuro de la humanidad y el medio ambiente (Painting et al., 1995). Actua...
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International Nuclear Information System (INIS)
Vasavada, A.B.
1988-01-01
3-Acetyldeoxynivalenol (3-ADN) is a highly toxic secondary metabolite elaborated by several species of the filamentous fungus, Fusarium. The present research was aimed at investigating the cultural conditions governing the production of 3-ADN, and to elucidate the mechanism and metabolic regulation of the toxin production in submerged cultures. A two-stage submerged culture was developed in which the biosynthetically active mycelium from YEPD medium was transferred to the production medium to achieve as much as 90-105 mg/l 3-ADN. Phosphate inhibition was found to be a regulatory factor in 3-ADN biosynthesis. While Mg +2 and Zn +2 at 1 mM increased 3-ADN yields by 60% and 76% respectively, and Fe +2 at 5 mM doubled 3-ADN yields, Mn +2 completely inhibited 3-ADN biosynthesis at all concentrations used suggesting its regulatory role in the toxin production. Modulation of 3-ADN biosynthesis by using various metabolic inhibitors and stimulators of the TCA cycle, fatty acid biosynthesis, and ergosterol biosynthesis yielded increased levels of 3-ADN possibly by channelling more acetyl Co-A into the toxin production pathway. This was further evidenced by 14 C-acetate pulse-feeding studies where highly labelled 3-ADN was obtained by using known metabolic inhibitors of the competing pathways thereby specifically channelling the label into 3-ADN synthesis
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Adiponectin inhibits insulin function in primary trophoblasts by PPARα-mediated ceramide synthesis.
Aye, Irving L M H; Gao, Xiaoli; Weintraub, Susan T; Jansson, Thomas; Powell, Theresa L
2014-04-01
Maternal adiponectin (ADN) levels are inversely correlated with birth weight, and ADN infusion in pregnant mice down-regulates placental nutrient transporters and decreases fetal growth. In contrast to the insulin-sensitizing effects in adipose tissue and muscle, ADN inhibits insulin signaling in the placenta. However, the molecular mechanisms involved are unknown. We hypothesized that ADN inhibits insulin signaling and insulin-stimulated amino acid transport in primary human trophoblasts by peroxisome proliferator-activated receptor-α (PPARα)-mediated ceramide synthesis. Primary human term trophoblast cells were treated with ADN and/or insulin. ADN increased the phosphorylation of p38 MAPK and PPARα. ADN inhibited insulin signaling and insulin-stimulated amino acid transport. This effect was dependent on PPARα, because activation of PPARα with an agonist (GW7647) inhibited insulin signaling and function, whereas PPARα-small interfering RNA reversed the effects of ADN on the insulin response. ADN increased ceramide synthase expression and stimulated ceramide production. C2-ceramide inhibited insulin signaling and function, whereas inhibition of ceramide synthase (with Fumonisin B1) reversed the effects of ADN on insulin signaling and amino acid transport. These findings are consistent with the model that maternal ADN limits fetal growth mediated by activation of placental PPARα and ceramide synthesis, which inhibits placental insulin signaling and amino acid transport, resulting in reduced fetal nutrient availability.
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Nan, Mei Hua; Park, Jeong-Sook; Myung, Chang-Seon
2010-01-01
Adiponectin (ADN), an insulin-sensitizing adipokine, stimulates glucose uptake, inhibits gluconeogenesis, and plays an important role in improving insulin sensitivity. Since blood levels of ADN are low in type 2 diabetes mellitus (DM), this study was designed to investigate the therapeutic effectiveness of increasing the ADN level through injection of plasmid DNA encoding ADN in type 2 DM. A non-obese type 2 DM mouse model was established via combined administration of streptozotocin with nicotinamide and exhibited significantly higher plasma glucose concentration and insulin resistance compared with normal controls according to oral glucose tolerance and insulin challenge tests. Plasmid DNA encoding mouse ADN from differentiated NIH3T3 adipocytes was constructed in pVAX1 (pVAX/ADN). Transfection of pVAX/ADN into various cell lines including HeLa, HT22, HEK293, HepG2, and SK-Hep1 cells, increased ADN mRNA expression levels in a dose-dependent manner. The administration of pVAX/ADN into non-obese type 2 DM mice via tail vein significantly increased the blood level of ADN and decreased the plasma glucose concentration. Moreover, the parameters related to insulin resistance (HOMA-IR) and insulin sensitivity (QUICKI) were significantly improved. These results suggest that ADN gene therapy could be a clinically effective tool for the treatment of type 2 DM.
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Shinahara, Masayuki; Nishiyama, Mitsuru; Iwasaki, Yasumasa; Nakayama, Shuichi; Noguchi, Toru; Kambayashi, Machiko; Okada, Yasushi; Tsuda, Masayuki; Stenzel-Poore, Mary P; Hashimoto, Kozo; Terada, Yoshio
2009-01-01
Adiponectin (AdN), an adipokine derived from the adipose tissue, has an insulin-sensitizing effect, and plasma AdN is shown to be decreased in obesity and/or insulin resistant state. To clarify whether changes in AdN are also responsible for the development of glucocorticoid-induced insulin resistance, we examined AdN concentration in plasma and AdN expression in the adipose tissue, using corticotropin-releasing hormone (CRH) transgenic mouse (CRH-Tg), an animal model of Cushing syndrome. We found, unexpectedly, that plasma AdN levels in CRHTg were significantly higher than those in wild-type littermates (wild-type: 19.7+/-2.5, CRH-Tg: 32.4+/-3.1 microg/mL, pAdN mRNA and protein levels were significantly decreased in the adipose tissue of CRH-Tg. Bilateral adrenalectomy in CRH-Tg eliminated both their Cushing's phenotype and their increase in plasma AdN levels (wild-type/sham: 9.4+/-0.5, CRH-Tg/sham: 15.7+/-2.0, CRH-Tg/ADX: 8.5+/-0.4 microg/mL). These results strongly suggest that AdN is not a major factor responsible for the development of insulin resistance in Cushing syndrome. Our data also suggest that glucocorticoid increases plasma AdN levels but decreases AdN expression in adipocytes, the latter being explained possibly by the decrease in AdN metabolism in the Cushing state.
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1979-01-01
For NASA's Apollo program, McDonnell Douglas Astronautics Company, Huntington Beach, California, developed and built the S-IVB, uppermost stage of the three-stage Saturn V moonbooster. An important part of the development task was fabrication of a tank to contain liquid hydrogen fuel for the stage's rocket engine. The liquid hydrogen had to be contained at the supercold temperature of 423 degrees below zero Fahrenheit. The tank had to be perfectly insulated to keep engine or solar heat from reaching the fuel; if the hydrogen were permitted to warm up, it would have boiled off, or converted to gaseous form, reducing the amount of fuel available to the engine. McDonnell Douglas' answer was a supereffective insulation called 3D, which consisted of a one-inch thickness of polyurethane foam reinforced in three dimensions with fiberglass threads. Over a 13-year development and construction period, the company built 30 tanks and never experienced a failure. Now, after years of additional development, an advanced version of 3D is finding application as part of a containment system for transporting Liquefied Natural Gas (LNG) by ship.
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Genética y Arqueología : Análisis molecular de ADN procedente de restos esqueléticos.
Directory of Open Access Journals (Sweden)
N. Izaguirre
1998-01-01
Full Text Available La recuperación de moléculas de ADN mitocondrial (ADNmt de muestras esqueléticas de diversa antigüedad, permite estudiar la variabilidad genética de los grupos humanos del pasado. El análisis del ADNmt en tejido antiguo presenta una ventaja fundamental frente al nuclear, debido a su alto número de copias por célula. Los principales problemas metodológicos descritos en este tipo de análisis, han podido resolverse en aquellos casos en que las muestras presentaban buenas condiciones de preservación. Estos han sido fundamentalmente : 1.- inhibición de la amplificación,2.- autentificación de los resultados y 3.- detección y eliminación de la contaminación. La variabilidad en el éxito de la amplificación entre individuos de un mismo yacimiento, indica que las condiciones individuales de cada inhumación son más importantes que la antigüedad. Por otro lado, las piezas dentarias han demostrado ser el material más adecuado para el estudio del ADNmt antiguo. La interpretación de los datos a nivel poblacional sólo es posible en aquellos yacimientos que presentan un amplio número de individuos, dado el relativamente bajo rendimiento de la metodología.
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MD-11 PCA - View of aircraft on ramp
1995-01-01
This McDonnell Douglas MD-11 is taxiing to a position on the flightline at NASA's Dryden Flight Research Center, Edwards, California, following its completion of the first and second landings ever performed by a transport aircraft under engine power only (on Aug. 29, 1995). The milestone flight, with NASA research pilot and former astronaut Gordon Fullerton at the controls, was part of a NASA project to develop a computer-assisted engine control system that enables a pilot to land a plane safely when its normal control surfaces are disabled. The Propulsion-Controlled Aircraft (PCA) system uses standard autopilot controls already present in the cockpit, together with the new programming in the aircraft's flight control computers. The PCA concept is simple. For pitch control, the program increases thrust to climb and reduces thrust to descend. To turn right, the autopilot increases the left engine thrust while decreasing the right engine thrust. The initial Propulsion-Controlled Aircraft studies by NASA were carried out at Dryden with a modified twin-engine F-15 research aircraft.
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MD-11 PCA - Closeup view of aircraft on ramp
1995-01-01
This McDonnell Douglas MD-11 has taxied to a position on the flightline at NASA's Dryden Flight Research Center, Edwards, California, following its completion of the first and second landings ever performed by a transport aircraft under engine power only (on Aug. 29, 1995). The milestone flight, with NASA research pilot and former astronaut Gordon Fullerton at the controls, was part of a NASA project to develop a computer-assisted engine control system that enables a pilot to land a plane safely when its normal control surfaces are disabled. The Propulsion-Controlled Aircraft (PCA) system uses standard autopilot controls already present in the cockpit, together with the new programming in the aircraft's flight control computers. The PCA concept is simple. For pitch control, the program increases thrust to climb and reduces thrust to descend. To turn right, the autopilot increases the left engine thrust while decreasing the right engine thrust. The initial Propulsion-Controlled Aircraft studies by NASA were carried out at Dryden with a modified twin-engine F-15 research aircraft.
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Scotto E, Carlos
2006-01-01
Las secuencias del ADN mitocondrial (ADNmt) de animales vertebrados han sido estudiadas desde hace 25 años. Sólo ahora se cuenta con el genoma mitocondrial completo de muchas especies para hacer un análisis más detallado de cómo evolucionan sus secuencias y como esto influye en la construcción de árboles filogenéticos con la aplicación de los diferentes modelos matemáticos y programas bioinformáticos. En definitiva, aún existe un recurrente debate evolutivo acerca de cuáles secuencias mitocon...
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Crabill, Norman L.
1956-01-01
The National Advisory Committee for Aeronautics has conducted a flight test of a model approximating the McDonnell F3H-lN airplane configuration to determine its pitch-up and buffet boundaries, as well as the usual longitudinal stability derivatives obtainable from the pulsed- tail technique. The test was conducted by the freely flying rocket- boosted model technique developed at the Langley Laboratory; results were obtained at Mach numbers from 0.40 to 1.27 at corresponding Reynolds numbers of 2.6 x 10(exp 6) and 9.0 x 10(exp 6). The phenomena of pitch-up, buffet, and maximum lift were encountered at Mach numbers between 0.42 and 0.85. The lift-curve slope and wing-root bending-moment slope increased with increasing angle of attack, whereas the static stability decreased with angle of attack at subsonic speeds and increased at transonic speeds. There was little change in trim at low lift at transonic speeds.
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Adiponectin modulates synaptic plasticity in hippocampal dentate gyrus.
Pousti, Farideh; Ahmadi, Ramesh; Mirahmadi, Fatemeh; Hosseinmardi, Narges; Rohampour, Kambiz
2018-01-01
Recent studies have suggested the involvement of some metabolic hormones in memory formation and synaptic plasticity. Insulin dysfunction is known as an essential process in the pathogenesis of sporadic Alzheimer's disease (AD). In this study we examined whether adiponectin (ADN), as an insulin-sensitizing adipokine, could affect hippocampal synaptic plasticity. Field potential recordings were performed on intracerebroventricular (icv) cannulated urethane anesthetized rats. After baseline recording from dentate gyrus (DG) and 10min prior to high/low frequency stimulation (HFS/LFS), 10μl icv ADN (600nm) were injected. The slope of field excitatory postsynaptic potentials (fEPSP) and the amplitude of population spikes (PS) were recorded in response to perforanth path (PP) stimulation. Paired pulse stimuli and ADN injection without any stimulation protocols were also evaluated. Application of ADN before HFS increased PS amplitude recorded in DG significantly (P≤0.05) in comparison to HFS only group. ADN suppressed the potency of LFS to induce long-term depression (LTD), causing a significant difference between fEPSP slope (P≤0.05) and PS amplitude (P≤0.01) between ADN+LFS and ADN group. Paired pulse stimuli applied at 20ms intervals showed more paired pulse facilitation (PPF), when applied after ADN (P≤0.05). ADN induced a chemical long-term potentiation (LTP) in which fEPSP slope and PS amplitude increased significantly (P≤0.01 and P≤0.05, respectively). It is concluded that ADN is able to potentiate the HFS-induced LTP and suppress LFS-induced LTD. ADN caused a chemical LTP, when applied without any tetanic protocol. ADN may enhance the presynaptic release probability. Copyright © 2017. Published by Elsevier B.V.
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NASA Airborne Astronomy Ambassadors (AAA) Professional Development and NASA Connections
Backman, D. E.; Clark, C.; Harman, P. K.
2017-12-01
NASA's Airborne Astronomy Ambassadors (AAA) program is a three-part professional development (PD) experience for high school physics, astronomy, and earth science teachers. AAA PD consists of: (1) blended learning via webinars, asynchronous content learning, and in-person workshops, (2) a STEM immersion experience at NASA Armstrong's B703 science research aircraft facility in Palmdale, California, and (3) ongoing opportunities for connection with NASA astrophysics and planetary science Subject Matter Experts (SMEs). AAA implementation in 2016-18 involves partnerships between the SETI Institute and seven school districts in northern and southern California. AAAs in the current cohort were selected by the school districts based on criteria developed by AAA program staff working with WestEd evaluation consultants. The selected teachers were then randomly assigned by WestEd to a Group A or B to support controlled testing of student learning. Group A completed their PD during January - August 2017, then participated in NASA SOFIA science flights during fall 2017. Group B will act as a control during the 2017-18 school year, then will complete their professional development and SOFIA flights during 2018. A two-week AAA electromagnetic spectrum and multi-wavelength astronomy curriculum aligned with the Science Framework for California Public Schools and Next Generation Science Standards was developed by program staff for classroom delivery. The curriculum (as well as the AAA's pre-flight PD) capitalizes on NASA content by using "science snapshot" case studies regarding astronomy research conducted by SOFIA. AAAs also interact with NASA SMEs during flight weeks and will translate that interaction into classroom content. The AAA program will make controlled measurements of student gains in standards-based learning plus changes in student attitudes towards STEM, and observe & record the AAAs' implementation of curricular changes. Funded by NASA: NNX16AC51
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Institutional Goal Priorities in Texas: A Look at an Associate Degree Nursing Program.
De Leon, John E.
A study examined the perceptions of four key constituent groups from the Southeast College Associate Degree Nursing (ADN) program regarding institutional goal priorities. (Southeast College manages the ADN program for the Houston Community College System.) The study involved 23 ADN faculty, 13 college administrators, 128 ADN students, and 5 ADN…
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Through the Eyes of NASA: NASA's 2017 Eclipse Education Progam
Mayo, L.
2017-12-01
Over the last three years, NASA has been developing plans to bring the August 21st total solar eclipse to the nation, "as only NASA can", leveraging its considerable space assets, technology, scientists, and its unmatched commitment to science education. The eclipse, long anticipated by many groups, represents the largest Big Event education program that NASA has ever undertaken. It is the latest in a long string of successful Big Event international celebrations going back two decades including both transits of Venus, three solar eclipses, solar maximum, and mission events such as the MSL/Curiosity landing on Mars, and the launch of the Lunar Reconnaissance Orbiter (LRO) to name a few. This talk will detail NASA's program development methods, strategic partnerships, and strategies for using this celestial event to engage the nation and improve overall science literacy.
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NASA Earthdata Forums: An Interactive Venue for Discussions of NASA Data and Earth Science
Hearty, Thomas J., III; Acker, James; Meyer, Dave; Northup, Emily A.; Bagwell, Ross E.
2017-01-01
We demonstrate how students and teachers can register to use the NASA Earthdata Forums. The NASA Earthdata forums provide a venue where registered users can pose questions regarding NASA Earth science data in a moderated forum, and have their questions answered by data experts and scientific subject matter experts connected with NASA Earth science missions and projects. Since the forums are also available for research scientists to pose questions and discuss pertinent topics, the NASA Earthdata Forums provide a unique opportunity for students and teachers to gain insight from expert scientists and enhance their knowledge of the many different ways that NASA Earth observations can be used in research and applications.
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NASA EEE Parts and NASA Electronic Parts and Packaging (NEPP) Program Update 2018
Label, Kenneth A.; Sampson, Michael J.; Pellish, Jonathan A.; Majewicz, Peter J.
2018-01-01
NASA Electronic Parts and Packaging (NEPP) Program and NASA Electronic Parts Assurance Group (NEPAG) are NASAs point-of-contacts for reliability and radiation tolerance of EEE parts and their packages. This presentation includes an FY18 program overview.
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NASA Parts Selection List (NPSL) WWW Site http://nepp.nasa.gov/npsl
Brusse, Jay
2000-01-01
The NASA Parts Selection List (NPSL) is an on-line resource for electronic parts selection tailored for use by spaceflight projects. The NPSL provides a list of commonly used electronic parts that have a history of satisfactory use in spaceflight applications. The objective of this www site is to provide NASA projects, contractors, university experimenters, et al with an easy to use resource that provides a baseline of electronic parts from which designers are encouraged to select. The NPSL is an ongoing resource produced by Code 562 in support of the NASA HQ funded NASA Electronic Parts and Packaging (NEPP) Program. The NPSL is produced as an electronic format deliverable made available via the referenced www site administered by Code 562. The NPSL does not provide information pertaining to patented or proprietary information. All of the information contained in the NPSL is available through various other public domain resources such as US Military procurement specifications for electronic parts, NASA GSFC's Preferred Parts List (PPL-21), and NASA's Standard Parts List (MIL-STD975).
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1997-01-01
NASA is piloting fiscal year (FY) 1997 Accountability Reports, which streamline and upgrade reporting to Congress and the public. The document presents statements by the NASA administrator, and the Chief Financial Officer, followed by an overview of NASA's organizational structure and the planning and budgeting process. The performance of NASA in four strategic enterprises is reviewed: (1) Space Science, (2) Mission to Planet Earth, (3) Human Exploration and Development of Space, and (4) Aeronautics and Space Transportation Technology. Those areas which support the strategic enterprises are also reviewed in a section called Crosscutting Processes. For each of the four enterprises, there is discussion about the long term goals, the short term objectives and the accomplishments during FY 1997. The Crosscutting Processes section reviews issues and accomplishments relating to human resources, procurement, information technology, physical resources, financial management, small and disadvantaged businesses, and policy and plans. Following the discussion about the individual areas is Management's Discussion and Analysis, about NASA's financial statements. This is followed by a report by an independent commercial auditor and the financial statements.
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1998-01-01
This NASA Strategic Plan describes an ambitious, exciting vision for the Agency across all its Strategic Enterprises that addresses a series of fundamental questions of science and research. This vision is so challenging that it literally depends on the success of an aggressive, cutting-edge advanced technology development program. The objective of this plan is to describe the NASA-wide technology program in a manner that provides not only the content of ongoing and planned activities, but also the rationale and justification for these activities in the context of NASA's future needs. The scope of this plan is Agencywide, and it includes technology investments to support all major space and aeronautics program areas, but particular emphasis is placed on longer term strategic technology efforts that will have broad impact across the spectrum of NASA activities and perhaps beyond. Our goal is to broaden the understanding of NASA technology programs and to encourage greater participation from outside the Agency. By relating technology goals to anticipated mission needs, we hope to stimulate additional innovative approaches to technology challenges and promote more cooperative programs with partners outside NASA who share common goals. We also believe that this will increase the transfer of NASA-sponsored technology into nonaerospace applications, resulting in an even greater return on the investment in NASA.
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NASA Information Technology Implementation Plan
2000-01-01
NASA's Information Technology (IT) resources and IT support continue to be a growing and integral part of all NASA missions. Furthermore, the growing IT support requirements are becoming more complex and diverse. The following are a few examples of the growing complexity and diversity of NASA's IT environment. NASA is conducting basic IT research in the Intelligent Synthesis Environment (ISE) and Intelligent Systems (IS) Initiatives. IT security, infrastructure protection, and privacy of data are requiring more and more management attention and an increasing share of the NASA IT budget. Outsourcing of IT support is becoming a key element of NASA's IT strategy as exemplified by Outsourcing Desktop Initiative for NASA (ODIN) and the outsourcing of NASA Integrated Services Network (NISN) support. Finally, technology refresh is helping to provide improved support at lower cost. Recently the NASA Automated Data Processing (ADP) Consolidation Center (NACC) upgraded its bipolar technology computer systems with Complementary Metal Oxide Semiconductor (CMOS) technology systems. This NACC upgrade substantially reduced the hardware maintenance and software licensing costs, significantly increased system speed and capacity, and reduced customer processing costs by 11 percent.
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Novel immunomodulatory effects of adiponectin on dendritic cell functions.
Tsang, Julia Yuen Shan; Li, Daxu; Ho, Derek; Peng, Jiao; Xu, Aimin; Lamb, Jonathan; Chen, Yan; Tam, Paul Kwong Hang
2011-05-01
Adiponectin (ADN) is an adipocytokine with anti-inflammatory properties. Although it has been reported that ADN can inhibit the immunostimulatory function of monocytes and macrophages, little is known of its effect on dendritic cells (DC). Recent data suggest that ADN can regulate immune responses. DCs are uniquely specialised antigen presenting cells that play a central role in the initiation of immunity and tolerance. In this study, we have investigated the immuno- modulatory effects of ADN on DC functions. We found that ADN has only moderate effect on the differentiation of murine bone marrow (BM) derived DCs but altered the phenotype of DCs. The expression of major histocompatibilty complex class II (MHCII), CD80 and CD86 on ADN conditioned DCs (ADN-DCs) was lower than that on untreated cells. The production of IL-12p40 was also suppressed in ADN-DCs. Interestingly, ADN treated DCs showed an increase in the expression of the inhibitory molecule, programmed death-1 ligand (PDL-1) compared to untreated cells. In vitro co-culture of ADN-DCs with allogeneic T cells led to a decrease in T cell proliferation and reduction of IL-2 production. Concomitant with that, a higher percentage of CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) was detected in co-cultures of T cells and ADN-DCs. Blocking PD-1/PDL-1 pathway could partially restore T cell function. These findings suggest that the immunomodulatory effect of ADN on immune responses could be at least partially be mediated by its ability to alter DC function. The PD-1/PDL-1 pathway and the enhancement of Treg expansion are implicated in the immunomodulatory mechanisms. Copyright © 2010 Elsevier B.V. All rights reserved.
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Directory of Open Access Journals (Sweden)
M. Mercado
2005-12-01
Full Text Available Este trabajo validó la técnica de PCR para la detección de L. monocytogenes a partir de ADN de cultivos puros y en muestras de leches crudas, quesos frescos, carne de res y carne de pollo. En DNA de cultivos puros la sensibilidad, la especificidad y la reproducibilidad encontrada fue de 100%, 101UFC/ml y K=1,respectivamente. Para la extracción del ADN de los alimentos se emplearon dos métodos, el primero, basado en la precipitación alcohólica en presencia de NaI, lo que redujo en gran medida las grasas; permitiendo la detección directa de 10 1 UFC/ml en leche cruda y 105 UFC/g en queso fresco. El segundo método, basado en la extracción con lisozima, proteinasa K y fenol-cloroformo, permitió establecer límites de detección de 102 y 104 UFC/g para las carnes de res y pollo respectivamente. La PCR se basó enla especificidad de los iniciadores LI1/U1 que amplificaron una banda de 938 pb (identificación de género característica del rDNA 16S y los iniciadores LF/LR que amplificaron una banda de 750 pbcaracterística del gen hlyA (identificación de especie. Los resultados de la validación reportaron con relación al método “Gold Standard” una reproducibilidad, sensibilidad y especificidad del 100% en leches crudas. Para las muestras de queso frescos se reportó una reproducibilidad de 97%, sensibilidad 96.3% y especificidad del 100%, para la carne de pollo la reproducibilidad fue 98.43%, sensibilidad96.9%, especificidad 100%, valor predictivo positivo 100% y valor predictivo negativo 100%, para la carne de res todos los parámetros fueron 100%. El método “Gold Standard” reportó 100% para todos losparámetros. El trabajo muestra que ambas técnicas pueden ser utilizadas para detectar L. monocytogenes en este tipo de alimentos y que la PCR reduce el tiempo de ensayo considerablemente.
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Holmes, C. P.; Kinter, J. L.; Beebe, R. F.; Feigelson, E.; Hurlburt, N. E.; Mentzel, C.; Smith, G.; Tino, C.; Walker, R. J.
2017-12-01
Two years ago NASA established the Ad Hoc Big Data Task Force (BDTF - https://science.nasa.gov/science-committee/subcommittees/big-data-task-force), an advisory working group with the NASA Advisory Council system. The scope of the Task Force included all NASA Big Data programs, projects, missions, and activities. The Task Force focused on such topics as exploring the existing and planned evolution of NASA's science data cyber-infrastructure that supports broad access to data repositories for NASA Science Mission Directorate missions; best practices within NASA, other Federal agencies, private industry and research institutions; and Federal initiatives related to big data and data access. The BDTF has completed its two-year term and produced several recommendations plus four white papers for NASA's Science Mission Directorate. This presentation will discuss the activities and results of the TF including summaries of key points from its focused study topics. The paper serves as an introduction to the papers following in this ESSI session.
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F-15B ACTIVE with thrust vectoring nozzles on test stand
1995-01-01
This November 13, 1995, photograph of the F-15 Advanced Controls Technology for Integrated Vehicles (ACTIVE) at NASA's Dryden Flight Research Center, Edwards, California, shows the thrust stand being used for ground testing of a new thrust-vectoring concept involving two new Pratt & Whitney nozzles that can turn up to 20 degrees in any direction. These nozzles give the aircraft thrust control in the pitch (up and down) and yaw (left and right) directions. This will reduce drag and increase fuel economy or range as compared with conventional aerodynamic controls, which increase the retarding forces (drag) acting upon the aircraft. These tests could lead to significant performance increases for military and commercial aircraft. The research program is the product of a collaborative effort by NASA, the Air Force's Wright Laboratory, Pratt & Whitney, and McDonnell Douglas Aerospace.
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Directory of Open Access Journals (Sweden)
JOSÉ G MEDINA H
2012-12-01
Full Text Available Este artículo identifica en una muestra de 21 empresas del sector agroindustrial del departamento de Antioquia - Colombia factores claves de innovación, que establecen una relación con los conceptos básicos de la estructura del acido desoxirribonucleico (ADN, con el fin de ayudar a las empresas a gestionar su estructura para la innovación. Para el desarrollo de este estudio se tomaron las variables definidas por el perfil innovador de la Metodología de Gestión Tecnológica por Proyectos 'MGT', la cual describe un perfil de las empresas respecto a las cuatro dimensiones de innovación: producto, proceso, mercadeo y organización [1] definidas por la Organización para la Cooperación y Desarrollo Económico [2]. Posteriormente se construyó una base de datos con los resultados del perfil innovador de empresas del sector agroindustrial obtenidos de la herramienta MGT; por último se implementó la herramienta estadística de análisis multivariable la cual permitió definir los factores claves de innovación más frecuentes e importantes de las empresas a las cuales se les aplicó la metodología 'MGT'[3].Este artigo identifica uma amostra de 21 empresas no setor de agronegócios do departamento de Antioquia - Colômbia fatores-chave da inovação, em seguida, estabelecer uma relação com o básico da estrutura do ácido desoxirribonucléico (ADN, a fim de ajudar as empresas estrutura para gerir a inovação. Para o desenvolvimento deste estudo foram tomadas pelo perfil de variáveis definidas Metodologia de Gestão de Projetos Inovadores de Tecnologia 'MGT', que descreve um perfil das empresas em relação as quatro dimensões da inovação: produto, processo, marketing e organização [1] definida pela Organização para a Cooperação e Desenvolvimento Econômico [2]. Mais tarde, ele construiu um banco de dados com os resultados do perfil inovador de empresas do agronegócio se reuniram a partir da MGT, e finalmente implementou a
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Directory of Open Access Journals (Sweden)
Caselli Chiara
2012-11-01
Full Text Available Abstract Background The role of systemic and myocardial adiponectin (ADN in dilated cardiomyopathy is still debated. We tested the regulation of both systemic and myocardial ADN and the relationship with AMP-activated protein kinase (AMPK activity in a swine model of non-ischemic dilated cardiomyopathy. Methods and results Cardiac tissue was collected from seven instrumented adult male minipigs by pacing the left ventricular (LV free wall (180 beats/min, 3 weeks, both from pacing (PS and opposite sites (OS, and from five controls. Circulating ADN levels were inversely related to global and regional cardiac function. Myocardial ADN in PS was down-regulated compared to control (p Conclusions Paradoxically, circulating ADN did not show any cardioprotective effect, confirming its role as negative prognostic biomarker of heart failure. Myocardial ADN was reduced in PS compared to control in an AMPK-independent fashion, suggesting the occurrence of novel mechanisms by which reduced cardiac ADN levels may regionally mediate the decline of cardiac function.
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NASA and the National Climate Assessment: Promoting awareness of NASA Earth science
Leidner, A. K.
2014-12-01
NASA Earth science observations, models, analyses, and applications made significant contributions to numerous aspects of the Third National Climate Assessment (NCA) report and are contributing to sustained climate assessment activities. The agency's goal in participating in the NCA was to ensure that NASA scientific resources were made available to understand the current state of climate change science and climate change impacts. By working with federal agency partners and stakeholder communities to develop and write the report, the agency was able to raise awareness of NASA climate science with audiences beyond the traditional NASA community. To support assessment activities within the NASA community, the agency sponsored two competitive programs that not only funded research and tools for current and future assessments, but also increased capacity within our community to conduct assessment-relevant science and to participate in writing assessments. Such activities fostered the ability of graduate students, post-docs, and senior researchers to learn about the science needs of climate assessors and end-users, which can guide future research activities. NASA also contributed to developing the Global Change Information System, which deploys information from the NCA to scientists, decision makers, and the public, and thus contributes to climate literacy. Finally, NASA satellite imagery and animations used in the Third NCA helped the pubic and decision makers visualize climate changes and were frequently used in social media to communicate report key findings. These resources are also key for developing educational materials that help teachers and students explore regional climate change impacts and opportunities for responses.
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Update on NASA Microelectronics Activities
Label, Kenneth A.; Sampson, Michael J.; Casey, Megan; Lauenstein, Jean-Marie
2017-01-01
Mission Statement: The NASA Electronic Parts and Packaging (NEPP) Program provides NASA's leadership for developing and maintaining guidance for the screening, qualification, test. and usage of EEE parts by NASA as well as in collaboration with other government Agencies and industry. NASA Space Technology Mission Directorate (STMD) "STMD rapidly develops, demonstrates, and infuses revolutionary, high-payoff technologies through transparent, collaborative partnerships, expanding the boundaries of the aerospace enterprise." Mission Statement: The Space Environments Testing Management Office (SETMO) will identify, prioritize, and manage a select suite of Agency key capabilities/assets that are deemed to be essential to the future needs of NASA or the nation, including some capabilities that lack an adequate business base over the budget horizon. NESC mission is to perform value-added independent testing, analysis, and assessments of NASA's high-risk projects to ensure safety and mission success. NASA Space Environments and Avionics Fellows as well as Radiation and EEE Parts Community of Practice (CoP) leads.
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MD-11 PCA - Research flight team photo
1995-01-01
On Aug. 30, 1995, a the McDonnell Douglas MD-11 transport aircraft landed equipped with a computer-assisted engine control system that has the potential to increase flight safety. In landings at NASA Dryden Flight Research Center, Edwards, California, on August 29 and 30, the aircraft demonstrated software used in the aircraft's flight control computer that essentially landed the MD-11 without a need for the pilot to manipulate the flight controls significantly. In partnership with McDonnell Douglas Aerospace (MDA), with Pratt & Whitney and Honeywell helping to design the software, NASA developed this propulsion-controlled aircraft (PCA) system following a series of incidents in which hydraulic failures resulted in the loss of flight controls. This new system enables a pilot to operate and land the aircraft safely when its normal, hydraulically-activated control surfaces are disabled. This August 29, 1995, photo shows the MD-11 team. Back row, left to right: Tim Dingen, MDA pilot; John Miller, MD-11 Chief pilot (MDA); Wayne Anselmo, MD-11 Flight Test Engineer (MDA); Gordon Fullerton, PCA Project pilot; Bill Burcham, PCA Chief Engineer; Rudey Duran, PCA Controls Engineer (MDA); John Feather, PCA Controls Engineer (MDA); Daryl Townsend, Crew Chief; Henry Hernandez, aircraft mechanic; Bob Baron, PCA Project Manager; Don Hermann, aircraft mechanic; Jerry Cousins, aircraft mechanic; Eric Petersen, PCA Manager (Honeywell); Trindel Maine, PCA Data Engineer; Jeff Kahler, PCA Software Engineer (Honeywell); Steve Goldthorpe, PCA Controls Engineer (MDA). Front row, left to right: Teresa Hass, Senior Project Management Analyst; Hollie Allingham (Aguilera), Senior Project Management Analyst; Taher Zeglum, PCA Data Engineer (MDA); Drew Pappas, PCA Project Manager (MDA); John Burken, PCA Control Engineer.
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Directory of Open Access Journals (Sweden)
J. M. González-Navajas
2007-10-01
Full Text Available Durante la última década hemos presenciado un aumento de la cantidad de datos relativos a la presencia de translocación bacteriana en los modelos experimentales de cirrosis. Sin embargo, los estudios clínicos se han visto limitados por la falta de métodos no invasivos para estudiar dicho fenómeno. En los últimos años, las investigaciones realizadas en nuestro laboratorio se han centrado en la detección del ADN bacteriano en el suero y el líquido ascítico de los pacientes con cirrosis y ascitis estéril, y en las implicaciones clínicas que ello conlleva. Al principio, gracias a un método basado en la reacción en cadena de la polimerasa (PCR y el secuenciamiento automatizado de nucleótidos, pudimos detectar e identificar la presencia de fragmentos de ADN bacteriano en dichos pacientes con ascitis no neutrocítica y con cultivo negativo. Desde entonces hemos acumulado una serie de datos que indican que la presencia de ADN bacteriano podría desempeñar un papel importante no sólo como marcador de translocación bacteriana, sino también como factor pronóstico a corto plazo. Expondremos aquí el pasado, el presente y el futuro de esta línea de investigación.During the last decade, we have witnessed an increase in the amount of data related with the presence of bacterial translocation in experimental models of cirrhosis. However, clinical studies have been limited by the lack of non-invasive methods to study this phenomenon. Over the past years, the research developed in our laboratory has been focused on the detection of bacterial DNA in serum and ascitic fluid of patients with cirrhosis and sterile ascites, the clinical and immunological implications of such finding. Initially, by means of a polymerase chain reaction (PCR-based method and automated nucleotide sequencing, we were able to detect and identify the presence of fragments of bacterial DNA in the mentioned patients with culture-negative, non-neutrocytic ascites. Since
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Toll, David L.
2011-01-01
With increasing population pressure and water usage coupled with climate variability and change, water issues are being reported by numerous groups as the most critical environmental problems facing us in the 21st century. Competitive uses and the prevalence of river basins and aquifers that extend across boundaries engender political tensions between communities, stakeholders and countries. In addition to the numerous water availability issues, water quality related problems are seriously affecting human health and our environment. The potential crises and conflicts especially arise when water is competed among multiple uses. For example, urban areas, environmental and recreational uses, agriculture, and energy production compete for scarce resources, not only in the Western U.S. but throughout much of the U.S. and also in numerous parts of the world. Mitigating these conflicts and meeting water demands and needs requires using existing water resources more efficiently. The NASA Water Resources Program Element works to use NASA products and technology to address these critical water issues. The primary goal of the Water Resources is to facilitate application of NASA Earth science products as a routine use in integrated water resources management for the sustainable use of water. This also includes the extreme events of drought and floods and the adaptation to the impacts from climate change. NASA satellite and Earth system observations of water and related data provide a huge volume of valuable data in both near-real-time and extended back nearly 50 years about the Earth's land surface conditions such as precipitation, snow, soil moisture, water levels, land cover type, vegetation type, and health. NASA Water Resources Program works closely to use NASA and Earth science data with other U.S. government agencies, universities, and non-profit and private sector organizations both domestically and internationally. The NASA Water Resources Program organizes its
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NASA Operational Environment Team (NOET): NASA's key to environmental technology
Cook, Beth
1993-01-01
NASA has stepped forward to face the environmental challenge to eliminate the use of Ozone-Layer Depleting Substances (OLDS) and to reduce our Hazardous Air Pollutants (HAP) by 50 percent in 1995. These requirements have been issued by the Clean Air Act, the Montreal Protocol, and various other legislative acts. A proactive group, the NASA Operational Environment Team or NOET, received its charter in April 1992 and was tasked with providing a network through which replacement activities and development experiences can be shared. This is a NASA-wide team which supports the research and development community by sharing information both in person and via a computerized network, assisting in specification and standard revisions, developing cleaner propulsion systems, and exploring environmentally-compliant alternatives to current processes.
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75 FR 70951 - NASA Advisory Council; NASA Commercial Space Committee; Meeting
2010-11-19
.... ADDRESSES: NASA Headquarters, 300 E Street, SW., Glennan Conference Center Room 1Q39, Washington, DC 20546... identification such as a driver's license to enter the NASA Headquarters building (West Lobby--Visitor Control..., company affiliation (if applicable) to include address, telephone number, and their title, place of birth...
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Franklin, James A.; Stortz, Michael W.; Borchers, Paul F.; Moralez, Ernesto, III
1996-01-01
Flight experiments were conducted on Ames Research Center's V/STOL Systems Research Aircraft (VSRA) to assess the influence of advanced control modes and head-up displays (HUD's) on flying qualities for precision approach and landing operations. Evaluations were made for decelerating approaches to hover followed by a vertical landing and for slow landings for four control/display mode combinations: the basic YAV-8B stability augmentation system; attitude command for pitch, roll, and yaw; flightpath/acceleration command with translational rate command in the hover; and height-rate damping with translational-rate command. Head-up displays used in conjunction with these control modes provided flightpath tracking/pursuit guidance and deceleration commands for the decelerating approach and a mixed horizontal and vertical presentation for precision hover and landing. Flying qualities were established and control usage and bandwidth were documented for candidate control modes and displays for the approach and vertical landing. Minimally satisfactory bandwidths were determined for the translational-rate command system. Test pilot and engineer teams from the Naval Air Warfare Center, the Boeing Military Airplane Group, Lockheed Martin, McDonnell Douglas Aerospace, Northrop Grumman, Rolls-Royce, and the British Defense Research Agency participated in the program along with NASA research pilots from the Ames and Lewis Research Centers. The results, in conjunction with related ground-based simulation data, indicate that the flightpath/longitudinal acceleration command response type in conjunction with pursuit tracking and deceleration guidance on the HUD would be essential for operation to instrument minimums significantly lower than the minimums for the AV-8B. It would also be a superior mode for performing slow landings where precise control to an austere landing area such as a narrow road is demanded. The translational-rate command system would reduce pilot workload for
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The writers guide to NASA. [NASA Centers and public affairs contacts
1978-01-01
NASA services of interest to writers and to the news media include personal interviews, daily audio reports of major missions, and projects via automated telephone, research assistance from historians or history monitors at technical libraries, the use of a collection of historical photographs, and the free loan of sound films of NASA research and development activities. The names and phones numbers are listed for public affairs contacts at Headquarters and at each of the major centers and their component installations. An overview of the six NASA program offices is included along with a vicinity map of each center and a description of their facilities and management responsibilities.
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NASA Space Radiation Laboratory
Federal Laboratory Consortium — The NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory is a NASA funded facility, delivering heavy ion beams to a target area where scientists...
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Mazrooie, R; Rohampour, K; Zamani, M; Hosseinmardi, N; Zeraati, M
2017-06-01
Alzheimer's disease (AD) has been reported to be linked with diabetes mellitus and insulin resistance. Adiponectin (ADN), an adipocytokine secreted from adipose tissue, is involved in the regulation of insulin sensitivity, energy homeostasis, and mitochondrial dysfunction. In this study, we examined the effect of ADN on passive avoidance memory in animal model of sporadic AD (sAD). On days 1 and 3 after cannulation, rats received intracerebroventricular (icv) injection of streptozotocin (STZ) (3 mg/kg). Thirty minutes before the learning process, animals received saline or ADN in different doses (6, 60, and 600 µg). The step-through latency (STL) and total time spent in the dark compartment (TDC) were recorded and analyzed. In STZ-treated rats, STL was significantly decreased, whereas TDC showed a dramatic increase. In ADN-treated rats, STL was significantly increased (P ADN (P ADN is useful to improve the STZ-induced memory impairment. This study showed, for the first time, that icv administration of ADN could improve the memory acquisition in animal model of sAD.
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2011-10-17
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (11-095)] NASA Advisory Committee; Renewal of NASA's International Space Station Advisory Committee Charter AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of renewal and amendment of the Charter of the International...
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Surface energy and crystallization phenomena of ammonium dinitramide
Energy Technology Data Exchange (ETDEWEB)
Teipel, Ulrich; Heintz, Thomas [Fraunhofer-Institut fuer Chemische Technologie (ICT), PO Box 1240, D-76318 Pfinztal (Germany)
2005-12-01
Ammonium dinitramide (ADN) was characterized during recrystallization from the melt. The surface tension of molten ADN at 97 C was measured to be 89 mN/m. The wetting angles between molten ADN and different solid surfaces (polytetrafluoroethylene, glass, steel, and aluminum) were determined. The wettability depends on the surface tension of molten ADN, the free surface energy of the solid surfaces and the interfacial tension between the solid and liquid. Observations of the recrystallization behavior of molten ADN showed that nucleation does not occur, even at super cooling rates of 70 K. Crystallization can be initiated by the application of seed crystals. (Abstract Copyright [2005], Wiley Periodicals, Inc.)
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NASA University Program Management Information System
2000-01-01
As basic policy, NASA believes that colleges and universities should be encouraged to participate in the nation's space and aeronautics program to the maximum extent practicable. Indeed, universities are considered as partners with government and industry in the nation's aerospace program. NASA:s objective is to have them bring their scientific, engineering, and social research competence to bear on aerospace problems and on the broader social, economic, and international implications of NASA's technical and scientific programs. It is expected that, in so doing, universities will strengthen both their research and their educational capabilities to contribute more effectively to the national well-being. NASA field codes and certain Headquarters program offices provide funds for those activities in universities which contribute to the mission needs of that particular NASA element. Although NASA has no predetermined amount of money to devote to university activities, the effort funded each year is substantial. This annual report is one means of documenting the NASA-university relationship, frequently denoted, collectively, as NASA's University Program. This report is consistent with agency accounting records, as the data is obtained from NASA:s Financial and Contractual Status (FACS) System, operated by the Financial Management Division and the Procurement Office. However, in accordance with interagency agreements, the orientation differs from that required for financial or procurement purposes. Any apparent discrepancies between this report and other NASA procurement or financial reports stem from the selection criteria for the data.* This report was prepared by the Education Division/FE, Office of Human Resources and Education, using a management information system which was modernized during FY 1993.
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Independent Orbiter Assessment (IOA): Assessment of instrumental subsystem FMEA/CIL
Gardner, J. R.; Addis, A. W.
1988-01-01
The McDonnell Douglas Astronautics Company (MDAC) was selected in June 1986 to perform an Independent Orbiter Assessment (IOA) of the Failure Modes and Effects Analysis (FMEA) and Critical Items List (CIL). The IOA effort first completed an analysis of the Instrumentation hardware, generating draft failure modes and potential critical items. To preserve independence, this analysis was accomplished without reliance upon the results contained within the NASA FMEA/CIL documentation. The IOA results were then compared to the NASA FMEA/CIL baseline. A resolution of each discrepancy from the comparison is provided through additional analysis as required. The results of that comparison for the Orbiter Instrumentation hardware are documented. The IOA product for Instrumentation analysis consisted of 107 failure mode worksheets that resulted in 22 critical items being identified. Comparison was made to the Pre 51-L NASA baseline with 14 Post 51-L FMEAs added, which consists of 96 FMEAs and 18 CIL items. This comparison produced agreement on all but 25 FMEAs which caused differences in 5 CIL items.
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F-15B ACTIVE with thrust vectoring nozzles on test stand at sunrise
1995-01-01
This November 13, 1995, photograph of the F-15 Advanced Controls Technology for Integrated Vehicles (ACTIVE) at NASA's Dryden Flight Research Center, Edwards, California, shows the aircraft on a test stand at sunrise. Not shown in this photograph are the aircraft's two new Pratt & Whitney nozzles that can turn up to 20 degrees in any direction. These nozzles give the aircraft thrust control in the pitch (up and down) and yaw (left and right) directions. This will reduce drag and increase fuel economy or range as compared with conventional aerodynamic controls, which increase the retarding forces (drag) acting upon the aircraft. These tests could result in significant performance increases for military and commercial aircraft. The research program is the product of a collaborative effort by NASA, the Air Force's Wright Laboratory, Pratt & Whitney, and McDonnell Douglas Aerospace. The aircraft was originally built as an F-15B (Serial #71-0290).
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NASA Product Peer Review Process
Jenks, Ken
2009-01-01
This viewgraph presentation describes NASA's product peer review process. The contents include: 1) Inspection/Peer Review at NASA; 2) Reasons for product peer reviews; 3) Different types of peer reviews; and 4) NASA requirements for peer reviews. This presentation also includes a demonstration of an actual product peer review.
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Lawton, Brandon L.; Smith, D. A.; SMD Astrophysics E/PO Community, NASA
2013-01-01
The NASA Science Education and Public Outreach Forums support the NASA Science Mission Directorate (SMD) and its education and public outreach (E/PO) community in enhancing the coherence, efficiency, and effectiveness of SMD-funded E/PO programs. As a part of this effort, the Astrophysics Forum is coordinating a collaborative project among the NASA SMD astrophysics missions and E/PO programs to create a broader impact for the use of real NASA data in classrooms. Among NASA's major education goals is the training of students in the Science, Technology, Engineering, and Math (STEM) disciplines. The use of real data, from some of the most sophisticated observatories in the world, provide educators an authentic opportunity to teach students basic science process skills, inquiry, and real-world applications of the STEM subjects. The goal of this NASA SMD astrophysics community collaboration is to find a way to maximize the reach of existing real data products produced by E/PO professionals working with NASA E/PO grants and missions in ways that enhance the teaching of the STEM subjects. We present an initial result of our collaboration: defining levels of basic science process skills that lie at the heart of authentic scientific research and national education standards (AAAS Benchmarks) and examples of NASA data products that align with those levels. Our results are the beginning of a larger goal of utilizing the new NASA education resource catalog, NASA Wavelength, for the creation of progressions that tie NASA education resources together. We aim to create an informational sampler that illustrates how an educator can use the NASA Wavelength resource catalog to connect NASA real-data resources that meet the educational goals of their class.
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Prados, A. I.; Blevins, B.; Hook, E.
2015-12-01
NASA ARSET http://arset.gsfc.nasa.gov has been providing applied remote sensing training since 2008. The goals of the program are to develop the technical and analytical skills necessary to utilize NASA resources for decision-support. The program has reached over 3500 participants, with 1600 stakeholders from 100 countries in 2015 alone. The target audience for the program are professionals engaged in environmental management in the public and private sectors, such as air quality forecasters, public utilities, water managers and non-governmental organizations engaged in conservation. Many program participants have little or no expertise in NASA remote sensing, and it's frequently their very first exposure to NASA's vast resources. One the key challenges for the program has been the evolution and refinement of its approach to communicating NASA data access, research, and ultimately its value to stakeholders. We discuss ARSET's best practices for sharing NASA science, which include 1) training ARSET staff and other NASA scientists on methods for science communication, 2) communicating the proper amount of scientific information at a level that is commensurate with the technical skills of program participants, 3) communicating the benefit of NASA resources to stakeholders, and 4) getting to know the audience and tailoring the message so that science information is conveyed within the context of agencies' unique environmental challenges.
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NASA IMAGESEER: NASA IMAGEs for Science, Education, Experimentation and Research
Le Moigne, Jacqueline; Grubb, Thomas G.; Milner, Barbara C.
2012-01-01
A number of web-accessible databases, including medical, military or other image data, offer universities and other users the ability to teach or research new Image Processing techniques on relevant and well-documented data. However, NASA images have traditionally been difficult for researchers to find, are often only available in hard-to-use formats, and do not always provide sufficient context and background for a non-NASA Scientist user to understand their content. The new IMAGESEER (IMAGEs for Science, Education, Experimentation and Research) database seeks to address these issues. Through a graphically-rich web site for browsing and downloading all of the selected datasets, benchmarks, and tutorials, IMAGESEER provides a widely accessible database of NASA-centric, easy to read, image data for teaching or validating new Image Processing algorithms. As such, IMAGESEER fosters collaboration between NASA and research organizations while simultaneously encouraging development of new and enhanced Image Processing algorithms. The first prototype includes a representative sampling of NASA multispectral and hyperspectral images from several Earth Science instruments, along with a few small tutorials. Image processing techniques are currently represented with cloud detection, image registration, and map cover/classification. For each technique, corresponding data are selected from four different geographic regions, i.e., mountains, urban, water coastal, and agriculture areas. Satellite images have been collected from several instruments - Landsat-5 and -7 Thematic Mappers, Earth Observing-1 (EO-1) Advanced Land Imager (ALI) and Hyperion, and the Moderate Resolution Imaging Spectroradiometer (MODIS). After geo-registration, these images are available in simple common formats such as GeoTIFF and raw formats, along with associated benchmark data.
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Williams-Byrd, Julie; Arney, Dale; Rodgers, Erica; Antol, Jeff; Simon, Matthew; Hay, Jason; Larman, Kevin
2015-01-01
NASA is engaged in transforming human spaceflight. The Agency is shifting from an exploration-based program with human activities focused on low Earth orbit (LEO) and targeted robotic missions in deep space to a more sustainable and integrated pioneering approach. Through pioneering, NASA seeks to address national goals to develop the capacity for people to work, learn, operate, live, and thrive safely beyond the Earth for extended periods of time. However, pioneering space involves more than the daunting technical challenges of transportation, maintaining health, and enabling crew productivity for long durations in remote, hostile, and alien environments. This shift also requires a change in operating processes for NASA. The Agency can no longer afford to engineer systems for specific missions and destinations and instead must focus on common capabilities that enable a range of destinations and missions. NASA has codified a capability driven approach, which provides flexible guidance for the development and maturation of common capabilities necessary for human pioneers beyond LEO. This approach has been included in NASA policy and is captured in the Agency's strategic goals. It is currently being implemented across NASA's centers and programs. Throughout 2014, NASA engaged in an Agency-wide process to define and refine exploration-related capabilities and associated gaps, focusing only on those that are critical for human exploration beyond LEO. NASA identified 12 common capabilities ranging from Environmental Control and Life Support Systems to Robotics, and established Agency-wide teams or working groups comprised of subject matter experts that are responsible for the maturation of these exploration capabilities. These teams, called the System Maturation Teams (SMTs) help formulate, guide and resolve performance gaps associated with the identified exploration capabilities. The SMTs are defining performance parameters and goals for each of the 12 capabilities
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Ataques de nervios in relation to anxiety sensitivity among island Puerto Ricans.
Cintrón, Jennifer A; Carter, Michele M; Sbrocco, Tracy
2005-12-01
This study investigated the symptom profile of ataques de nervios (ADN) among Puerto Rican volunteers from the community who self-identified as having experienced at least one ataque. As expected, the most commonly reported ataques-specific symptoms were crying, anger, nervousness, and becoming hysterical. Comparing the responses of those with ADN to those with no history of ADN but who reported elevated anxiety sensitivity (AS) indicated that both groups were comparable on measures of depression, state and trait anxiety, and associated panic symptoms. As expected, both groups scored significantly higher on all measures than did participants with no history of ADN and low AS with the exception of the measure of state anxiety. It is unclear, however, whether the overlap in symptom severity between those with ADN and those with elevated anxiety sensitivity indicates that ADN and AS are the same or distinct conditions.
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Collins, Jacob
2008-01-01
This viewgraph presentation is a review of the career paths for chemicals engineer at NASA (specifically NASA Johnson Space Center.) The author uses his personal experience and history as an example of the possible career options.
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NASA's Software Safety Standard
Ramsay, Christopher M.
2007-01-01
NASA relies more and more on software to control, monitor, and verify its safety critical systems, facilities and operations. Since the 1960's there has hardly been a spacecraft launched that does not have a computer on board that will provide command and control services. There have been recent incidents where software has played a role in high-profile mission failures and hazardous incidents. For example, the Mars Orbiter, Mars Polar Lander, the DART (Demonstration of Autonomous Rendezvous Technology), and MER (Mars Exploration Rover) Spirit anomalies were all caused or contributed to by software. The Mission Control Centers for the Shuttle, ISS, and unmanned programs are highly dependant on software for data displays, analysis, and mission planning. Despite this growing dependence on software control and monitoring, there has been little to no consistent application of software safety practices and methodology to NASA's projects with safety critical software. Meanwhile, academia and private industry have been stepping forward with procedures and standards for safety critical systems and software, for example Dr. Nancy Leveson's book Safeware: System Safety and Computers. The NASA Software Safety Standard, originally published in 1997, was widely ignored due to its complexity and poor organization. It also focused on concepts rather than definite procedural requirements organized around a software project lifecycle. Led by NASA Headquarters Office of Safety and Mission Assurance, the NASA Software Safety Standard has recently undergone a significant update. This new standard provides the procedures and guidelines for evaluating a project for safety criticality and then lays out the minimum project lifecycle requirements to assure the software is created, operated, and maintained in the safest possible manner. This update of the standard clearly delineates the minimum set of software safety requirements for a project without detailing the implementation for those
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NASA's Bio-Inspired Acoustic Absorber Concept
Koch, L. Danielle
2017-01-01
Transportation noise pollutes our worlds cities, suburbs, parks, and wilderness areas. NASAs fundamental research in aviation acoustics is helping to find innovative solutions to this multifaceted problem. NASA is learning from nature to develop the next generation of quiet aircraft.The number of road vehicles and airplanes has roughly tripled since the 1960s. Transportation noise is audible in nearly all the counties across the US. Noise can damage your hearing, raise your heart rate and blood pressure, disrupt your sleep, and make communication difficult. Noise pollution threatens wildlife when it prevents animals from hearing prey, predators, and mates. Noise regulations help drive industry to develop quieter aircraft. Noise standards for aircraft have been developed by the International Civil Aviation Organization and adopted by the US Federal Aviation Administration. The US National Park Service is working with the Federal Aviation Administration to try to balance the demand for access to the parks and wilderness areas with preservation of the natural soundscape. NASA is helping by conceptualizing quieter, more efficient aircraft of the future and performing the fundamental research to make these concepts a reality someday. Recently, NASA has developed synthetic structures that can absorb sound well over a wide frequency range, and particularly below 1000 Hz, and which mimic the acoustic performance of bundles of natural reeds. We are adapting these structures to control noise on aircraft, and spacecraft. This technology might be used in many other industrial or architectural applications where acoustic absorbers have tight constraints on weight and thickness, and may be exposed to high temperatures or liquids. Information about this technology is being made available through reports and presentations available through the NASA Technical Report Server, http:ntrs.nasa.gov. Organizations who would like to collaborate with NASA or commercialize NASAs technology
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Neuropatía óptica hereditaria de Leber por mutación G11778A del ADN mitocondrial. Manejo de un caso
Directory of Open Access Journals (Sweden)
David Barreda Gago
2016-11-01
Full Text Available La neuropatía óptica hereditaria de Leber es una enfermedad genética mitocondrial que típicamente produce ceguera bilateral en adultos jóvenes varones. Además de la mutación del ADN mitocondrial son necesarios otros factores genéticos y ambientales para el desarrollo de la enfermedad. En la actualidad no existe un tratamiento eficaz para la neuropatía óptica hereditaria de Leber, pero el consejo genético en portadores asintomáticos es importante. Presentamos el caso clínico de un paciente de 23 años de edad que refiere pérdida de agudeza visual central aguda unilateral que se convierte en bilateral en semanas. La exploración del fondo de ojo (tortuosidad vascular peripapilar, telangiectasias e hiperemia papilar, la angiografía con fluoresceína (con ausencia de exudación y el engrosamiento de la capa de fibras nerviosas nos hacen sospechar la enfermedad. El test genético molecular confirma la neuropatía óptica hereditaria de Leber al encontrar la mutación G11778A en homoplasmia. A pesar del tratamiento con idebenona y suplementos vitamínicos la enfermedad evoluciona a atrofia papilar bilateral. El futuro parece estar en la terapia génica, actualmente en investigación.
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NASA University Program Management Information System
1999-01-01
As basic policy, NASA believes that colleges and universities should be encouraged to participate in the nation's space and aeronautics program to the maximum extent practicable. Indeed, universities are considered as partners with government and industry in the nation's aerospace program. NASA's objective is to have them bring their scientific, engineering, and social research competence to bear on aerospace problems and on the broader social, economic, and international implications of NASA's technical and scientific programs. It is expected that, in so doing, universities will strengthen both their research and their educational capabilities to contribute more effectively to the national well-being. NASA field codes and certain Headquarters program offices provide funds for those activities in universities which contribute to the mission needs of that particular NASA element. Although NASA has no predetermined amount of money to devote to university activities, the effort funded each year is substantial. (See the bar chart on the next page). This annual report is one means of documenting the NASA-university relationship, frequently denoted, collectively, as NASA's University Program. This report is consistent with agency accounting records, as the data is obtained from NASA's Financial and Contractual Status (FACS) System, operated by the Financial Management Division and the Procurement Office. However, in accordance with interagency agreements, the orientation differs from that required for financial or procurement purposes. Any apparent discrepancies between this report and other NASA procurement or financial reports stem from the selection criteria for the data.
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Bauer, Jeffrey Ervin; Mulac, Brenda Lynn
2010-01-01
Last year may prove to be a pivotal year for the National Aeronautics and Space Administration (NASA) in the Unmanned Aircraft Systems (UAS) arena, especially in relation to routine UAS access to airspace as NASA accepted an invitation to join the UAS Executive Committee (UAS ExCom). The UAS ExCom is a multi-agency, Federal executive-level committee comprised of the Federal Aviation Administration (FAA), Department of Defense (DoD), Department of Homeland Security (DHS), and NASA with the goals to: 1) Coordinate and align efforts between key Federal Government agencies to achieve routine safe federal public UAS operations in the National Airspace System (NAS); 2) Coordinate and prioritize technical, procedural, regulatory, and policy solutions needed to deliver incremental capabilities; 3) Develop a plan to accommodate the larger stakeholder community at the appropriate time; and 4) Resolve conflicts between Federal Government agencies (FAA, DoD, DHS, and NASA), related to the above goals. The committee was formed in recognition of the need of UAS operated by these agencies to access to the National Airspace System (NAS) to support operational, training, development and research requirements. In order to meet that need, technical, procedural, regulatory, and policy solutions are required to deliver incremental capabilities leading to routine access. The formation of the UAS ExCom is significant in that it represents a tangible commitment by FAA senior leadership to address the UAS access challenge. While the focus of the ExCom is government owned and operated UAS, civil UAS operations are bound to benefit by the progress made in achieving routine access for government UAS. As the UAS ExCom was forming, NASA's Aeronautics Research Mission Directorate began to show renewed interest in UAS, particularly in relation to the future state of the air transportation system under the Next Generation Air Transportation System (NextGen). NASA made funding from the American
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NASA tire/runway friction projects
Yager, Thomas J.
1995-01-01
The paper reviews several aspects of NASA Langley Research Center's tire/runway friction evaluations directed towards improving the safety and economy of aircraft ground operations. The facilities and test equipment used in implementing different aircraft tire friction studies and other related aircraft ground performance investigations are described together with recent workshop activities at NASA Wallops Flight Facility. An overview of the pending Joint NASA/Transport Canada/FM Winter Runway Friction Program is given. Other NASA ongoing studies and on-site field tests are discussed including tire wear performance and new surface treatments. The paper concludes with a description of future research plans.
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Flexible Electronics Development Supported by NASA
Baumann, Eric
2014-01-01
The commercial electronics industry is leading development in most areas of electronics for NASA applications; however, working in partnership with industry and the academic community, results from NASA research could lead to better understanding and utilization of electronic materials by the flexible electronics industry. Innovative ideas explored by our partners in industry and the broader U.S. research community help NASA execute our missions and bring new American products and services to the global technology marketplace. [Mike Gazarik, associate administrator for Space Technology, NASA Headquarters, Washington DC] This presentation provides information on NASA needs in electronics looking towards the future, some of the work being supported by NASA in flexible electronics, and the capabilities of the Glenn Research Center supporting the development of flexible electronics.
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Davis, Jeffrey R.; Richard, Elizabeth E.
2011-01-01
On October 18, 2010, the NASA Human Health and Performance center (NHHPC) was opened to enable collaboration among government, academic and industry members. Membership rapidly grew to 60 members (http://nhhpc.nasa.gov ) and members began identifying collaborative projects as detailed below. In addition, a first workshop in open collaboration and innovation was conducted on January 19, 2011 by the NHHPC resulting in additional challenges and projects for further development. This first workshop was a result of the SLSD successes in running open innovation challenges over the past two years. In 2008, the NASA Johnson Space Center, Space Life Sciences Directorate (SLSD) began pilot projects in open innovation (crowd sourcing) to determine if these new internet-based platforms could indeed find solutions to difficult technical problems. From 2008 to 2010, the SLSD issued 34 challenges, 14 externally and 20 internally. The 14 external challenges were conducted through three different vendors: InnoCentive, Yet2.com and TopCoder. The 20 internal challenges were conducted using the InnoCentive platform, customized to NASA use, and promoted as NASA@Work. The results from the 34 challenges involved not only technical solutions that were reported previously at the 61st IAC, but also the formation of new collaborative relationships. For example, the TopCoder pilot was expanded by the NASA Space Operations Mission Directorate to the NASA Tournament Lab in collaboration with Harvard Business School and TopCoder. Building on these initial successes, the NHHPC workshop in January of 2011, and ongoing NHHPC member discussions, several important collaborations are in development: Space Act Agreement between NASA and GE for collaborative projects, NASA and academia for a Visual Impairment / Intracranial Hypertension summit (February 2011), NASA and the DoD through the Defense Venture Catalyst Initiative (DeVenCI) for a technical needs workshop (June 2011), NASA and the San Diego Zoo
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Technology transfer at NASA - A librarian's view
Buchan, Ronald L.
1991-01-01
The NASA programs, publications, and services promoting the transfer and utilization of aerospace technology developed by and for NASA are briefly surveyed. Topics addressed include the corporate sources of NASA technical information and its interest for corporate users of information services; the IAA and STAR abstract journals; NASA/RECON, NTIS, and the AIAA Aerospace Database; the RECON Space Commercialization file; the Computer Software Management and Information Center file; company information in the RECON database; and services to small businesses. Also discussed are the NASA publications Tech Briefs and Spinoff, the Industrial Applications Centers, NASA continuing bibliographies on management and patent abstracts (indexed using the NASA Thesaurus), the Index to NASA News Releases and Speeches, and the Aerospace Research Information Network (ARIN).
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NASA Guidelines for Promoting Scientific and Research Integrity
Kaminski, Amy P.; Neogi, Natasha A.
2017-01-01
This guidebook provides an overarching summary of existing policies, activities, and guiding principles for scientific and research integrity with which NASA's workforce and affiliates must conform. This document addresses NASA's obligations as both a research institution and as a funder of research, NASA's use of federal advisory committees, NASA's public communication of research results, and professional development of NASA's workforce. This guidebook is intended to provide a single resource for NASA researchers, NASA research program administrators and project managers, external entities who do or might receive funding from NASA for research or technical projects, evaluators of NASA research proposals, NASA advisory committee members, NASA communications specialists, and members of the general public so that they can understand NASA's commitment to and expectations for scientific and integrity across the agency.
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2012-12-17
... (HDE) applications and the collection of information regarding the annual distribution number (ADN... that the Secretary of Health and Human Services (the Secretary) will assign an ADN for devices that meet the eligibility criteria to be permitted to be sold for profit. The ADN is defined as the number...
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Energy Technology Data Exchange (ETDEWEB)
Rutberg, Ph; Kolikov, V; Snetov, V; Stogov, A [Institute for Electrophysics and Electric Power Russian Academy of Sciences, 18 Dvortsovaya nab., St.-Petersburg, 191186 (Russian Federation); Moshkin, A; Khalilov, M, E-mail: Stogov2007@yandex.ru [Oryol State University, Medical Institute, October st. 25, Oryol, 302028 (Russian Federation)
2011-04-01
Promising direction of surgery related to the treatment of acute purulent wounds with chronic component could be utilization of aqueous dispersions of nanostructures (ADN) produced by pulsed electric discharge in water. The investigation is addressed to finding out the opportunity of usage of an ADN for treatment of purulent wounds with a chronic component and comparison of its efficiency with the widespread antiseptics. For realization of investigation was used ADN, which has maximal share of 'small' nanostructures (<100 nm) with the greatest surface electric charge. High activity of reparative processes is established at use of ADN and subsequent moderate changes of the further healing. The attributes of cellular atypia and preternatural representations about inflammatory reactions are not revealed at local use of ADN.
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International Nuclear Information System (INIS)
Rutberg, Ph; Kolikov, V; Snetov, V; Stogov, A; Moshkin, A; Khalilov, M
2011-01-01
Promising direction of surgery related to the treatment of acute purulent wounds with chronic component could be utilization of aqueous dispersions of nanostructures (ADN) produced by pulsed electric discharge in water. The investigation is addressed to finding out the opportunity of usage of an ADN for treatment of purulent wounds with a chronic component and comparison of its efficiency with the widespread antiseptics. For realization of investigation was used ADN, which has maximal share of 'small' nanostructures (<100 nm) with the greatest surface electric charge. High activity of reparative processes is established at use of ADN and subsequent moderate changes of the further healing. The attributes of cellular atypia and preternatural representations about inflammatory reactions are not revealed at local use of ADN.
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Ashish, Naveen
2005-01-01
We provide an overview of several ongoing NASA endeavors based on concepts, systems, and technology from the Semantic Web arena. Indeed NASA has been one of the early adopters of Semantic Web Technology and we describe ongoing and completed R&D efforts for several applications ranging from collaborative systems to airspace information management to enterprise search to scientific information gathering and discovery systems at NASA.
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Science@NASA: Direct to People!
Koczor, Ronald J.; Adams, Mitzi; Gallagher, Dennis; Whitaker, Ann (Technical Monitor)
2002-01-01
Science@NASA is a science communication effort sponsored by NASA's Marshall Space Flight Center. It is the result of a four year research project between Marshall, the University of Florida College of Journalism and Communications and the internet communications company, Bishop Web Works. The goals of Science@NASA are to inform, inspire, and involve people in the excitement of NASA science by bringing that science directly to them. We stress not only the reporting of the facts of a particular topic, but also the context and importance of the research. Science@NASA involves several levels of activity from academic communications research to production of content for 6 websites, in an integrated process involving all phases of production. A Science Communications Roundtable Process is in place that includes scientists, managers, writers, editors, and Web technical experts. The close connection between the scientists and the writers/editors assures a high level of scientific accuracy in the finished products. The websites each have unique characters and are aimed at different audience segments: 1. http://science.nasa.gov. (SNG) Carries stories featuring various aspects of NASA science activity. The site carries 2 or 3 new stories each week in written and audio formats for science-attentive adults. 2. http://liftoff.msfc.nasa.gov. Features stories from SNG that are recast for a high school level audience. J-Track and J-Pass applets for tracking satellites are our most popular product. 3. http://kids. msfc.nasa.gov. This is the Nursemaids site and is aimed at a middle school audience. The NASAKids Club is a new feature at the site. 4. http://www.thursdaysclassroom.com . This site features lesson plans and classroom activities for educators centered around one of the science stories carried on SNG. 5. http://www.spaceweather.com. This site gives the status of solar activity and its interactions with the Earth's ionosphere and magnetosphere.
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NASA's Coordinated Efforts to Enhance STEM Education: Bringing NASA Science into the Library
Meinke, B. K.; Thomas, C.; Eyermann, S.; Mitchell, S.; LaConte, K.; Hauck, K.
2015-11-01
Libraries are community-centered, free-access venues serving learners of all ages and backgrounds. Libraries also recognize the importance of science literacy and strive to include science in their programming portfolio. Scientists and educators can partner with local libraries to advance mutual goals of connecting the public to Earth and Space Science. In this interactive Special Interest Group (SIG) discussion, representatives from the NASA Science Mission Directorate (SMD) Education and Public Outreach (EPO) community's library collaborations discussed the opportunities for partnership with public and school libraries; explored the resources, events, and programs available through libraries; explored NASA science programming and professional development opportunities available for librarians; and strategized about the types of support that librarians require to plan and implement programs that use NASA data and resources. We also shared successes, lessons learned, and future opportunities for incorporating NASA science programming into library settings.
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Directory of Open Access Journals (Sweden)
Sandra Milena Quijano
2013-09-01
Full Text Available Introducción. Del 60 al 80 % de los pacientes con leucemia linfoblástica aguda de precursores B presentan alteraciones genéticas que influyen en el pronóstico de la enfermedad y en la biología del tumor. Objetivo. Analizar distintas alteraciones genéticas en leucemia linfoblástica aguda de precursores B en niños, y su relación con el inmunofenotipo y con la tasa de proliferación, en comparación con precursores B normales. Materiales y métodos. En 44 pacientes se evaluó, por citometría de flujo, el inmunofenotipo, el contenido de ADN y la proliferación, y por RT-PCR, las traslocaciones t(9;22, t(12;21, t(4;11 y t(1;19. Mediante un análisis jerarquizado de conglomerados se identificaron los patrones inmunofenotípicosde expresión asociados a las traslocaciones, tomando como referencia precursores B normales. Resultados. La cuantificación del ADN mostró que el 21 % de los casos de leucemia linfoblástica aguda de precursores B eran hiperdiploides de índice alto y, el 47,7 %, hiperdiploides de índice bajo. La presencia de hiperdiploidía se asoció con mayor proliferación tumoral y con inmunofenotipos aberrantes, que incluyeron expresión anormal de CD10, TdT, CD38 y CD45 y un mayor tamaño de los linfoblastos. La presencia de t(9;22 y t(12;21 discrimina células normales de células tumorales con aberraciones en la expresión de CD19, CD20, CD13, CD33, CD38, CD34 y CD45. Conclusiones. El perfil de aberraciones fenotípicas detectado en conjunto con anormalidades en la proliferación tumoral, se asocia de forma significativa con hiperdiploidiía de ADN y discrimina deforma clara linfoblastos con t(9;22 y t(12;21 de los precursores B normales. La identificación de estos parámetros será de gran utilidad como herramienta para la clasificación y seguimiento de lospacientes. doi: http://dx.doi.org/10.7705/biomedica.v33i3.1441
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NASA Resources for Educators and Public
Morales, Lester
2012-01-01
A variety of NASA Classroom Activities, Educator Guides, Lithographs, Posters and more are available to Pre ]service and In ]service Educators through Professional Development Workshops. We are here for you to engage, demonstrate, and facilitate the use of educational technologies, the NASA Website, NASA Education Homepage and more! We are here for you to inspire you by providing in-service and pre- service training utilizing NASA curriculum support products. We are here for you to partner with your local, state, and regional educational organizations to better educate ALL! NASA AESP specialists are experienced professional educators, current on education issues and familiar with the curriculum frameworks, educational standards, and systemic architecture of the states they service. These specialists provide engaging and inspiring student presentations and teacher training right at YOUR school at no cost to you! Experience free out-of-this-world interactive learning with NASA's Digital Learning Network. Students of all ages can participate in LIVE events with NASA Experts and Education Specialists. The Exploration Station provides NASA educational programs that introduce the application of Science, Technology, Engineering, & Mathematics, to students. Students participate in a variety of hands-on activities that compliment related topics taught by the classroom teacher. NASA KSC ERC can create Professional Development Workshops for teachers in groups of fifteen or more. Education/Information Specialists also assist educators in developing lessons to meet Sunshine State and national curriculum standards.
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Batteries at NASA - Today and Beyond
Reid, Concha M.
2015-01-01
NASA uses batteries for virtually all of its space missions. Batteries can be bulky and heavy, and some chemistries are more prone to safety issues than others. To meet NASA's needs for safe, lightweight, compact and reliable batteries, scientists and engineers at NASA develop advanced battery technologies that are suitable for space applications and that can satisfy these multiple objectives. Many times, these objectives compete with one another, as the demand for more and more energy in smaller packages dictates that we use higher energy chemistries that are also more energetic by nature. NASA partners with companies and universities, like Xavier University of Louisiana, to pool our collective knowledge and discover innovative technical solutions to these challenges. This talk will discuss a little about NASA's use of batteries and why NASA seeks more advanced chemistries. A short primer on battery chemistries and their chemical reactions is included. Finally, the talk will touch on how the work under the Solid High Energy Lithium Battery (SHELiB) grant to develop solid lithium-ion conducting electrolytes and solid-state batteries can contribute to NASA's mission.
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Biophysics of NASA radiation quality factors
International Nuclear Information System (INIS)
Cucinotta, Francis A.
2015-01-01
NASA has implemented new radiation quality factors (QFs) for projecting cancer risks from space radiation exposures to astronauts. The NASA QFs are based on particle track structure concepts with parameters derived from available radiobiology data, and NASA introduces distinct QFs for solid cancer and leukaemia risk estimates. The NASA model was reviewed by the US National Research Council and approved for use by NASA for risk assessment for International Space Station missions and trade studies of future exploration missions to Mars and other destinations. A key feature of the NASA QFs is to represent the uncertainty in the QF assessments and evaluate the importance of the QF uncertainty to overall uncertainties in cancer risk projections. In this article, the biophysical basis for the probability distribution functions representing QF uncertainties was reviewed, and approaches needed to reduce uncertainties were discussed. (author)
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2010-02-18
... of Health and Human Services will assign an annual distribution number (ADN) for devices indicated for use in a pediatric population or in a pediatric subpopulation. The ADN shall be based on the... notify the agency if the number of devices distributed during any calendar year exceeds the ADN. Section...
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The NASA risk management program
International Nuclear Information System (INIS)
Buchbinder, B.; Philipson, L.L.
1989-01-01
This paper reports that the NASA Risk Management Program has been established to ensure the appropriate application of risk-based procedures in support of the elimination, reduction, or acceptance of significant safety risks of concern in NASA. The term appropriate is emphasized, in that the particular procedures applied to each given risk are to reflect its character and prioritized importance, the technological and economic feasibility of its treatment. A number of key documents have been produced in support of this implementation. Databases, risk analysis tools, and risk communication procedures requisite to the execution of the risk management functions also are being developed or documented. Several risk management applications have been made and a comprehensive application to a major new NASA program is underway. This paper summarizes the development and current status of the NASA Risk Management Program. Some principal actions that have been carried out in NASA in consonance with the program are noted particularly, and views are presented on the program's likely future directions
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NASA Advanced Supercomputing Facility Expansion
Thigpen, William W.
2017-01-01
The NASA Advanced Supercomputing (NAS) Division enables advances in high-end computing technologies and in modeling and simulation methods to tackle some of the toughest science and engineering challenges facing NASA today. The name "NAS" has long been associated with leadership and innovation throughout the high-end computing (HEC) community. We play a significant role in shaping HEC standards and paradigms, and provide leadership in the areas of large-scale InfiniBand fabrics, Lustre open-source filesystems, and hyperwall technologies. We provide an integrated high-end computing environment to accelerate NASA missions and make revolutionary advances in science. Pleiades, a petaflop-scale supercomputer, is used by scientists throughout the U.S. to support NASA missions, and is ranked among the most powerful systems in the world. One of our key focus areas is in modeling and simulation to support NASA's real-world engineering applications and make fundamental advances in modeling and simulation methods.
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NASA's computer science research program
Larsen, R. L.
1983-01-01
Following a major assessment of NASA's computing technology needs, a new program of computer science research has been initiated by the Agency. The program includes work in concurrent processing, management of large scale scientific databases, software engineering, reliable computing, and artificial intelligence. The program is driven by applications requirements in computational fluid dynamics, image processing, sensor data management, real-time mission control and autonomous systems. It consists of university research, in-house NASA research, and NASA's Research Institute for Advanced Computer Science (RIACS) and Institute for Computer Applications in Science and Engineering (ICASE). The overall goal is to provide the technical foundation within NASA to exploit advancing computing technology in aerospace applications.
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NASA's Applied Sciences for Water Resources
Doorn, Bradley; Toll, David; Engman, Ted
2011-01-01
The Earth Systems Division within NASA has the primary responsibility for the Earth Science Applied Science Program and the objective to accelerate the use of NASA science results in applications to help solve problems important to society and the economy. The primary goal of the Earth Science Applied Science Program is to improve future and current operational systems by infusing them with scientific knowledge of the Earth system gained through space-based observation, assimilation of new observations, and development and deployment of enabling technologies, systems, and capabilities. This paper discusses one of the major problems facing water resources managers, that of having timely and accurate data to drive their decision support tools. It then describes how NASA?s science and space based satellites may be used to overcome this problem. Opportunities for the water resources community to participate in NASA?s Water Resources Applications Program are described.
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Manzo, Michelle A.
2007-01-01
In 2007, the NASA Engineering Safety Center (NESC) chartered the NASA Aerospace Flight Battery Systems Working Group to bring forth and address critical battery-related performance/manufacturing issues for NASA and the aerospace community. A suite of tasks identifying and addressing issues related to Ni-H2 and Li-ion battery chemistries was submitted and selected for implementation. The current NESC funded are: (1) Wet Life of Ni-H2 Batteries (2) Binding Procurement (3) NASA Lithium-Ion Battery Guidelines (3a) Li-Ion Performance Assessment (3b) Li-Ion Guidelines Document (3b-i) Assessment of Applicability of Pouch Cells for Aerospace Missions (3b-ii) High Voltage Risk Assessment (3b-iii) Safe Charge Rates for Li-Ion Cells (4) Availability of Source Material for Li-Ion Cells (5) NASA Aerospace Battery Workshop This presentation provides a brief overview of the tasks in the 2007 plan and serves as an introduction to more detailed discussions on each of the specific tasks.
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2013-04-03
... that the Secretary of Health and Human Services (the Secretary) will assign an ADN for devices that meet the eligibility criteria to be permitted to be sold for profit. The ADN is defined as the number... the Agency if the number of devices distributed during any calendar year exceeds the ADN. Section 520...
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Quantitative risk analysis of a space shuttle subsystem
International Nuclear Information System (INIS)
Frank, M.V.
1989-01-01
This paper reports that in an attempt to investigate methods for risk management other than qualitative analysis techniques, NASA has funded pilot study quantitative risk analyses for space shuttle subsystems. The authors performed one such study of two shuttle subsystems with McDonnell Douglas Astronautics Company. The subsystems were the auxiliary power units (APU) on the orbiter, and the hydraulic power units on the solid rocket booster. The technology and results of the APU study are presented in this paper. Drawing from a rich in-flight database as well as from a wealth of tests and analyses, the study quantitatively assessed the risk of APU-initiated scenarios on the shuttle during all phases of a flight mission. Damage states of interest were loss of crew/vehicle, aborted mission, and launch scrub. A quantitative risk analysis approach to deciding on important items for risk management was contrasted with the current NASA failure mode and effects analysis/critical item list approach
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Flight testing a propulsion-controlled aircraft emergency flight control system on an F-15 airplane
Burcham, F. W., Jr.; Burken, John; Maine, Trindel A.
1994-01-01
Flight tests of a propulsion-controlled aircraft (PCA) system on an F-15 airplane have been conducted at the NASA Dryden Flight Research Center. The airplane was flown with all flight control surfaces locked both in the manual throttles-only mode and in an augmented system mode. In the latter mode, pilot thumbwheel commands and aircraft feedback parameters were used to position the throttles. Flight evaluation results showed that the PCA system can be used to land an airplane that has suffered a major flight control system failure safely. The PCA system was used to recover the F-15 airplane from a severe upset condition, descend, and land. Pilots from NASA, U.S. Air Force, U.S. Navy, and McDonnell Douglas Aerospace evaluated the PCA system and were favorably impressed with its capability. Manual throttles-only approaches were unsuccessful. This paper describes the PCA system operation and testing. It also presents flight test results and pilot comments.
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1995-01-01
This November 13, 1995, photograph of the underside of the F-15 Advanced Controls Technology for Integrated Vehicles (ACTIVE) at NASA's Dryden Flight Research Center, Edwards, California, shows the thrust stand being used for ground testing of a new thrust-vectoring concept. The twin-engine F-15 research aircraft is equipped with new Pratt & Whitney nozzles that can turn up to 20 degrees in any direction. They give the aircraft thrust control in the pitch (up and down) and yaw (left and right) directions. This will reduce drag and increase fuel economy or range as compared with conventional aerodynamic controls, which increase the retarding forces (drag) acting upon the aircraft. Ground testing during the first two weeks of November 1995 went well, and flight tests began in March 1996. These tests could result in significant performance increases for military and commercial aircraft. The research program is the product of a collaborative effort by NASA, the Air Force's Wright Laboratory, Pratt & Whitney, and McDonnell Douglas Aerospace.
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F-15B ACTIVE with thrust vectoring nozzles on test stand view from rear
1995-01-01
This November 13, 1995, photograph of the F-15 Advanced Controls Technology for Integrated Vehicles (ACTIVE) at NASA's Dryden Flight Research Center, Edwards, California, shows the aircraft's two new Pratt & Whitney nozzles that can turn up to 20 degrees in any direction. These nozzles give the aircraft thrust control in the pitch (up and down) and yaw (left and right) directions. This will reduce drag and increase fuel economy or range as compared with conventional aerodynamic controls, which increase the retarding forces (drag) acting upon the aircraft. Ground testing of a new thrust-vectoring concept employing the nozzles took place during the first two weeks of November 1995 and went well, and flight tests began in March 1996. These tests could result in significant performance increases for military and commercial aircraft. The research program is the product of a collaborative effort by NASA, the Air Force's Wright Laboratory, Pratt & Whitney, and McDonnell Douglas Aerospace.
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NASA directives master list and index
1995-01-01
This handbook sets forth in two parts, Master List of Management Directives and Index to NASA Management Directives, the following information for the guidance of users of the NASA Management Directives System. Chapter 1 contains introductory information material on how to use this handbook. Chapter 2 is a complete master list of agencywide management directives, describing each directive by type, number, effective date, expiration date, title, and organization code of the office responsible for the directive. Chapter 3 includes a consolidated numerical list of all delegations of authority and a breakdown of such delegation by the office or center to which special authority is assigned. Chapter 4 sets forth a consolidated list of all NASA handbooks (NHB's) and important footnotes covering the control and ordering of such documents. Chapter 5 is a consolidated list of NASA management directives applicable to the Jet Propulsion Laboratory. Chapter 6 is a consolidated list of NASA regulations published in the Code of Federal Regulations. Chapter 7 is a consolidated list of NASA regulations published in Title 14 of the Code of Federal Regulations. Complementary manuals to the NASA Management Directives System are described in Chapter 8. The second part contains an in depth alphabetical index to all NASA management directives other than handbooks, most of which are indexed by titles only.
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NASA Systems Engineering Handbook
Hirshorn, Steven R.; Voss, Linda D.; Bromley, Linda K.
2017-01-01
The update of this handbook continues the methodology of the previous revision: a top-down compatibility with higher level Agency policy and a bottom-up infusion of guidance from the NASA practitioners in the field. This approach provides the opportunity to obtain best practices from across NASA and bridge the information to the established NASA systems engineering processes and to communicate principles of good practice as well as alternative approaches rather than specify a particular way to accomplish a task. The result embodied in this handbook is a top-level implementation approach on the practice of systems engineering unique to NASA. Material used for updating this handbook has been drawn from many sources, including NPRs, Center systems engineering handbooks and processes, other Agency best practices, and external systems engineering textbooks and guides. This handbook consists of six chapters: (1) an introduction, (2) a systems engineering fundamentals discussion, (3) the NASA program project life cycles, (4) systems engineering processes to get from a concept to a design, (5) systems engineering processes to get from a design to a final product, and (6) crosscutting management processes in systems engineering. The chapters are supplemented by appendices that provide outlines, examples, and further information to illustrate topics in the chapters. The handbook makes extensive use of boxes and figures to define, refine, illustrate, and extend concepts in the chapters.
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Microgravity effects on electrodeposition of metals and metal-cermet mixtures
Maybee, George W.; Riley, Clyde; Coble, H. Dwain
1987-01-01
An experimental system, designed to investigate the potential advantages of electrodeposition in microgravity, is being developed by the McDonnell Douglas Astronautics Company-Huntsville Division and the University of Alabama in Huntsville. It is intended to fly as an Orbiter payload when NASA resumes STS operations. The system will provide power, thermal conditioning, command and control for the production of electrodeposits; system performance data will be recorded for post-flight analysis. Plated metal surfaces will be created using simple electrolytic cells with pure metal electrodes immersed in aqueous electrolytic solutions. Crystalline structure and other properties will be analyzed to identify differences between samples produced in flight and those obtained from ground-based operations.
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Hypersonic nozzle/afterbody CFD code validation. I - Experimental measurements
Spaid, Frank W.; Keener, Earl R.
1993-01-01
This study was conducted to obtain a detailed experimental description of the flow field created by the interaction of a single-expansion-ramp-nozzle flow with a hypersonic external stream. Data were obtained from a generic nozzle/afterbody model in the 3.5-Foot Hypersonic Wind Tunnel of the NASA Ames Research Center in a cooperative experimental program involving Ames and the McDonnell Douglas Research Laboratories. This paper presents experimental results consisting primarily of surveys obtained with a five-hole total-pressure/flow-direction probe and a total-temperature probe. These surveys were obtained in the flow field created by the interaction between the underexpanded jet plume and the external flow.
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Performance study for inlet installations
Bingaman, Donald C.
1992-01-01
A conceptual design trade study was conducted by McDonnell Aircraft Company (MCAIR) and NASA LARC PAB to determine the impact of inlet design features incorporated for reduced detectability on inlet performance, weight, and cost, for both fighter and attack-type aircraft. Quality Function Deployment (QFD) techniques were used to prioritize trade study issues, and select 'best' air induction system configurations for each of two notional aircraft, the Multi-Role Fighter (MRF) and the Advanced Medium Attack (AMA) bomber. Database deficiencies discovered in the trade study process were identified, and technology roadmaps were developed to address these deficiencies. Finally, two high speed inlet wind tunnel model concepts were developed for follow-on wind tunnel investigations.
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Globular adiponectin controls insulin-mediated vasoreactivity in muscle through AMPKα2
DEFF Research Database (Denmark)
de Boer, Michiel P; Meijer, Rick I; Richter, Erik
2016-01-01
Decreased tissue perfusion increases the risk of developing insulin resistance and cardiovascular disease in obesity, and decreased levels of globular adiponectin (gAdn) have been proposed to contribute to this risk. We hypothesized that gAdn controls insulin's vasoactive effects through AMP......-activated protein kinase (AMPK), specifically its α2 subunit, and studied the mechanisms involved. In healthy volunteers, we found that decreased plasma gAdn levels in obese subjects associate with insulin resistance and reduced capillary perfusion during hyperinsulinemia. In cultured human microvascular...... endothelial cells (HMEC), gAdn increased AMPK activity. In isolated muscle resistance arteries gAdn uncovered insulin-induced vasodilation by selectively inhibiting insulin-induced activation of ERK1/2, and the AMPK inhibitor compound C as well as genetic deletion of AMPKα2 blunted insulin...
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48 CFR 1842.271 - NASA clause.
2010-10-01
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true NASA clause. 1842.271 Section 1842.271 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION... NASA clause. Insert the clause at 1852.242-70, Technical Direction, when paragraph 3(m) of the NASA...
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Biophysics of NASA radiation quality factors.
Cucinotta, Francis A
2015-09-01
NASA has implemented new radiation quality factors (QFs) for projecting cancer risks from space radiation exposures to astronauts. The NASA QFs are based on particle track structure concepts with parameters derived from available radiobiology data, and NASA introduces distinct QFs for solid cancer and leukaemia risk estimates. The NASA model was reviewed by the US National Research Council and approved for use by NASA for risk assessment for International Space Station missions and trade studies of future exploration missions to Mars and other destinations. A key feature of the NASA QFs is to represent the uncertainty in the QF assessments and evaluate the importance of the QF uncertainty to overall uncertainties in cancer risk projections. In this article, the biophysical basis for the probability distribution functions representing QF uncertainties was reviewed, and approaches needed to reduce uncertainties were discussed. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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NASA's Internal Space Weather Working Group
St. Cyr, O. C.; Guhathakurta, M.; Bell, H.; Niemeyer, L.; Allen, J.
2011-01-01
Measurements from many of NASA's scientific spacecraft are used routinely by space weather forecasters, both in the U.S. and internationally. ACE, SOHO (an ESA/NASA collaboration), STEREO, and SDO provide images and in situ measurements that are assimilated into models and cited in alerts and warnings. A number of years ago, the Space Weather laboratory was established at NASA-Goddard, along with the Community Coordinated Modeling Center. Within that organization, a space weather service center has begun issuing alerts for NASA's operational users. NASA's operational user community includes flight operations for human and robotic explorers; atmospheric drag concerns for low-Earth orbit; interplanetary navigation and communication; and the fleet of unmanned aerial vehicles, high altitude aircraft, and launch vehicles. Over the past three years we have identified internal stakeholders within NASA and formed a Working Group to better coordinate their expertise and their needs. In this presentation we will describe this activity and some of the challenges in forming a diverse working group.
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DEFF Research Database (Denmark)
Sonne, Mette P; Højbjerre, Lise; Alibegovic, Amra A
2009-01-01
. Forearm blood flow (FBF) was measured by venous occlusion plethysmography upon stimulation with systemic hyperinsulinemia (291 +/- 11 pmol/L, pooled data from both groups) and upon intraarterial infusion of adenosine (ADN) and acetylcholine (ACH) +/- hyperinsulinemia. Forearm blood flow response to ADN...... and ACH was less in FDR vs CON (P ADN in CON (P
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The NASA Polarimetric Radar (NPOL)
Petersen, Walter A.; Wolff, David B.
2013-01-01
Characteristics of the NASA NPOL S-band dual-polarimetric radar are presented including its operating characteristics, field configuration, scanning capabilities and calibration approaches. Examples of precipitation science data collections conducted using various scan types, and associated products, are presented for different convective system types and previous field campaign deployments. Finally, the NASA NPOL radar location is depicted in its home base configuration within the greater Wallops Flight Facility precipitation research array supporting NASA Global Precipitation Measurement Mission ground validation.
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Shared Curriculum Model: A Promising Practice for Education Transformation.
Close, Liz; Gorski, Mary Sue; Sroczynski, Maureen; Farmer, Pat; Wortock, Jean
2015-12-01
The shared curriculum model is one of four successful models of academic progression identified through a consensus-building process facilitated by The Future of Nursing: Campaign for Action, with support from the Robert Wood Johnson Foundation, AARP, and the AARP Foundation. Seamless academic progression from the associate degree in nursing (ADN) to the baccalaureate degree in nursing (BSN) is achieved either by simultaneously revising both ADN and BSN curricula or by making targeted adjustments in ADN or BSN curricula to create a unified academic progression. Systematic vetting and definitive agreement on nursing prerequisites and corequisites, general education courses, nursing major content, and general degree requirements are necessary to ensure coordinated degree progression. A standardized set of expectations for beginning professional practice and for unique baccalaureate nursing knowledge ensures vital nursing content across the ADN-to-BSN continuum. Examples of state and regional ADN-to-BSN progression programs using the shared curriculum model are highlighted. The shared curriculum model is a promising practical and sustainable approach to seamless ADN-to-BSN academic progression. Copyright 2015, SLACK Incorporated.
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NASA Education Implementation Plan 2015-2017
National Aeronautics and Space Administration, 2015
2015-01-01
The NASA Education Implementation Plan (NEIP) provides an understanding of the role of NASA in advancing the nation's STEM education and workforce pipeline. The document outlines the roles and responsibilities that NASA Education has in approaching and achieving the agency's and administration's strategic goals in STEM Education. The specific…
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NASA Microgravity Materials Science Conference
Gillies, D. C. (Compiler); McCauley, D. E. (Compiler)
1999-01-01
The Microgravity Materials Science Conference was held July 14-16, 1998 at the Von Braun Center in Huntsville, AL. It was organized by the Microgravity Materials Science Discipline Working Group, sponsored by the Microgravity Research Division at NASA Headquarters, and hosted by the NASA Marshall Space Flight Center and the Alliance for Microgravity Materials Science and Applications. It was the third NASA conference of this type in the microgravity materials science discipline. The microgravity science program sponsored approximately 125 investigations and 100 principal investigators in FY98, almost all of whom made oral or poster presentations at this conference. The conference's purpose was to inform the materials science community of research opportunities in reduced gravity in preparation for a NASA Research Announcement scheduled for release in late 1998 by the Microgravity Research Division at NASA Headquarters. The conference was aimed at materials science researchers from academia, industry, and government. A tour of the Marshall Space Flight Center microgravity research facilities was held on July 16, 1998. This volume is comprised of the research reports submitted by the principal investigators after the conference.
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Roman, Juan A.
2014-01-01
This presentation provides an overview of the activities National Aeronautics and Space Administration (NASA) is doing to encourage innovation across the agency. All information provided is available publicly.
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Directory of Open Access Journals (Sweden)
Rey, I.
2006-05-01
Full Text Available This work presents the catalogue of preserved samples of animal species (vertebrate and invertebrate from Comunidad de Madrid kept in the Tissues and DNA Collection of the Museo Nacional de Ciencias Naturales. Percentages are shown, calculated against the total number of samples and animal class kept in the collection. This information shows the effort developed by the Museo Nacional de Ciencias Naturales to preserve at the genomic level the greatest possible level of genomic biodiversity in Comunidad de Madrid.
Este trabajo presenta el catálogo de muestras conservadas en la colección de Tejidos y ADN de las especies animales (vertebrados e invertebrados de la Comunidad de Madrid. Se proporcionan los porcentajes frente al total de las muestras conservadas en la colección y las clases animales representadas. Esta información pone de manifiesto el esfuerzo que el Museo Nacional de Ciencias Naturales realiza para conservar a nivel genómico el mayor porcentaje posible de la diversidad actual de la Comunidad de Madrid. -
NASA Technologies for Product Identification
Schramm, Fred, Jr.
2006-01-01
Since 1975 bar codes on products at the retail counter have been accepted as the standard for entering product identity for price determination. Since the beginning of the 21st century, the Data Matrix symbol has become accepted as the bar code format that is marked directly on a part, assembly or product that is durable enough to identify that item for its lifetime. NASA began the studies for direct part marking Data Matrix symbols on parts during the Return to Flight activities after the Challenger Accident. Over the 20 year period that has elapsed since Challenger, a mountain of studies, analyses and focused problem solutions developed by and for NASA have brought about world changing results. NASA Technical Standard 6002 and NASA Handbook 6003 for Direct Part Marking Data Matrix Symbols on Aerospace Parts have formed the basis for most other standards on part marking internationally. NASA and its commercial partners have developed numerous products and methods that addressed the difficulties of collecting part identification in aerospace operations. These products enabled the marking of Data Matrix symbols in virtually every situation and the reading of symbols at great distances, severe angles, under paint and in the dark without a light. Even unmarkable delicate parts now have a process to apply a chemical mixture called NanocodesTM that can be converted to a Data Matrix. The accompanying intellectual property is protected by 10 patents, several of which are licensed. Direct marking Data Matrix on NASA parts virtually eliminates data entry errors and the number of parts that go through their life cycle unmarked, two major threats to sound configuration management and flight safety. NASA is said to only have people and stuff with information connecting them. Data Matrix is one of the most significant improvements since Challenger to the safety and reliability of that connection. This presentation highlights the accomplishments of NASA in its efforts to develop
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Cui, Jian; Zhou, Jing; Peng, Ying; Chan, Andrew; Mao, Jingdong
2015-12-01
A detailed study on the solution chemistry of red soil in South China is presented. Data are collected from two simulated column-leaching experiments with an improved setup to evaluate the effects of atmospheric N deposition (ADN) composition and ADN flux on agricultural soil acidification using a (15)N tracer technique and an in situ soil solution sampler. The results show that solution pH values decline regardless of the increase of the NH4(+)/NO3(-) ratio in the ADN composition or ADN flux, while exchangeable Al(3+), Ca(2+), Mg(2+), and K(+) concentrations increase at different soil depths (20, 40, and 60 cm). Compared with the control, ADN (60 kg per ha per year N, NH4(+)/NO3(-) ratio of 2 : 1) decreases solution pH values, increases solution concentrations of NO3(-)-N, Al(3+), Ca(2+) and Mg(2+) at the middle and lower soil depths, and promotes their removal. NH4(+)-N was not detected in red soil solutions of all the three soil layers, which might be attributed to effects of nitrification, absorption and fixation in farmland red soil. Some of the NO3(-)-N concentrations at 40-60 cm soil depth exceed the safe drinking level of 10 mg L(-1), especially when the ADN flux is beyond 60 kg ha(-1) N. These features are critical for understanding the ADN agro-ecological effects, and for future assessment of ecological critical loads of ADN in red soil farmlands.
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NASA Airborne Science Program: NASA Stratospheric Platforms
Curry, Robert E.
2010-01-01
The National Aeronautics and Space Administration conducts a wide variety of remote sensing projects using several unique aircraft platforms. These vehicles have been selected and modified to provide capabilities that are particularly important for geophysical research, in particular, routine access to very high altitudes, long range, long endurance, precise trajectory control, and the payload capacity to operate multiple, diverse instruments concurrently. While the NASA program has been in operation for over 30 years, new aircraft and technological advances that will expand the capabilities for airborne observation are continually being assessed and implemented. This presentation will review the current state of NASA's science platforms, recent improvements and new missions concepts as well as provide a survey of emerging technologies unmanned aerial vehicles for long duration observations (Global Hawk and Predator). Applications of information technology that allow more efficient use of flight time and the ability to rapidly reconfigure systems for different mission objectives are addressed.
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NASA Ames Environmental Sustainability Report 2011
Clarke, Ann H.
2011-01-01
The 2011 Ames Environmental Sustainability Report is the second in a series of reports describing the steps NASA Ames Research Center has taken toward assuring environmental sustainability in NASA Ames programs, projects, and activities. The Report highlights Center contributions toward meeting the Agency-wide goals under the 2011 NASA Strategic Sustainability Performance Program.
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Dusenbery, P.; LaConte, K.; Holland, A.; Harold, J. B.; Johnson, A.; Randall, C.; Fitzhugh, G.
2017-12-01
NASA research programs are helping humanity understand the origin and evolution of galaxies, stars, and planets, how our Sun varies and impacts the heliosphere, and defining the conditions necessary to support life beyond Earth. As places that offer their services for free, public libraries have become the "public square" by providing a place where members of a community can gather for information, educational programming, and policy discussions. Libraries are also developing new ways to engage their patrons in STEM learning. The Space Science Institute's (SSI) National Center for Interactive Learning (NCIL) was funded by NASA`s Science Mission Directorate (SMD) to develop and implement a project called NASA@ My Library: A National Earth and Space Science Initiative That Connects NASA, Public Libraries and Their Communities. NCIL's STAR Library Network (STAR_Net) is providing important leverage to expand its community of practice that serves both librarians and STEM professionals. Seventy-five libraries were selected through a competitive application process to receive NASA STEM Facilitation Kits, NASA STEM Backpacks for circulation, financial resources, training, and partnership opportunities. Initial survey data from the 75 NASA@ My Library partners showed that, while they are actively providing programming, few STEM programs connected with NASA science and engineering. With the launch of the initiative - including training, resources, and STEM-related event opportunities - all 75 libraries are engaged in offering NASA-focused programs, including with NASA subject matter experts. This talk will highlight the impacts the initiative is having on both public library partners and many others across the country.
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NASA directives: Master list and index
1994-01-01
This Handbook sets forth in two parts the following information for the guidance of users of the NASA Management Directives System. Chapter 1 contains introductory information material on how to use this Handbook. Chapter 2 is a complete master list of Agency-wide management directives, describing each directive by type, number, effective date, expiration date, title, and organization code of the office responsible for the directive. Chapter 3 includes a consolidated numerical list of all delegations of authority and a breakdown of such delegation by the office of Installation to which special authority is assigned. Chapter 4 sets forth a consolidated list of all NASA Handbooks (NHB's) and important footnotes covering the control and ordering of such documents. Chapter 5 is a consolidated list of NASA management directives applicable to the Jet Propulsion Laboratory. Chapter 6 is a consolidated list of NASA management directives published in the code of Federal Regulations. Complementary manuals to the NASA Management Directives System are described in Chapter 7. Part B contains an in-depth alphabetical index to all NASA management directives other than Handbooks.
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NASA OSMA NDE Program Additive Manufacturing Foundational Effort
Waller, Jess; Walker, James; Burke, Eric; Wells, Douglas; Nichols, Charles
2016-01-01
NASA is providing key leadership in an international effort linking NASA and non-NASA resources to speed adoption of additive manufacturing (AM) to meet NASA's mission goals. Participants include industry, NASA's space partners, other government agencies, standards organizations and academia. Nondestructive Evaluation (NDE) is identified as a universal need for all aspects of additive manufacturing.
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New NASA Technologies for Space Exploration
Calle, Carlos I.
2015-01-01
NASA is developing new technologies to enable planetary exploration. NASA's Space Launch System is an advance vehicle for exploration beyond LEO. Robotic explorers like the Mars Science Laboratory are exploring Mars, making discoveries that will make possible the future human exploration of the planet. In this presentation, we report on technologies being developed at NASA KSC for planetary exploration.
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Ataques de nervios: culturally bound and distinct from panic attacks?
Keough, Meghan E; Timpano, Kiara R; Schmidt, Norman B
2009-01-01
The Diagnostic and Statistical Manual of Mental Disorders [DSM-IV-TR; American Psychiatric Association [APA], 2000) has emphasized the importance of understanding psychopathology within a cultural framework by including culture-bound syndromes within its appendices. These syndromes are proposed to be bound to certain cultures and distinct from other psychological disorders. Included among the syndromes are ataques de nervios (ADN), which are reported to be bound to the Hispanic culture and closely resemble panic attacks. However, the cultural distinctiveness and phenomenology of ADN has not been adequately investigated. The current study employed an ethnically diverse study sample (N=342) of undergraduates. Participants completed a number of measures that assessed acculturation, syndrome and anxiety risk factors. In contrast to the DSM-IV's conceptualization of ADN, the rate of ADN did not significantly vary across the three main groups (African American, Caucasian, and Hispanic participants) nor did it vary based on acculturation. More consistent with the DSM-IV, the symptom comparisons indicated some differentiation between ADN and panic attacks. The present report provides data indicating that ADNs, as described by the DSM-IV, are not unique to the Hispanic culture and are experienced by non-Hispanic individuals at similar rates to Hispanic-endorsement. The findings are consistent with the DSM-IV assertion that ADNs and PAs are distinct syndromes. (c) 2008 Wiley-Liss, Inc.
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NASA SMD STEM Activation: Enabling NASA Science Experts and Content into the Learning Environment
Hasan, Hashima; Erickson, Kristen
2018-01-01
The NASA Science Mission Directorate (SMD) restructured its efforts to enhance learning in science, technology, engineering, and mathematics (STEM) content areas through a cooperative agreement notice issued in 2015. This effort resulted in the competitive selection of 27 organizations to implement a strategic approach that leverages SMD’s unique assets. Three of these are exclusively directed towards Astrophysics. These unique assets include SMD’s science and engineering content and Science Discipline Subject Matter Experts. Awardees began their work during 2016 and span all areas of Earth and space science and the audiences NASA SMD intends to reach. The goal of the restructured STEM Activation program is to further enable NASA science experts and content into the learning environment more effectively and efficiently with learners of all ages. The objectives are to enable STEM education, improve US scientific literacy, advance national educational goals, and leverage efforts through partnerships. This presentation will provide an overview of the NASA SMD STEM Activation landscape and its commitment to meeting user needs.
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14 CFR 1221.103 - Establishment of the NASA Insignia.
2010-01-01
..., NASA Program Identifiers, NASA Flags, and the Agency's Unified Visual Communications System § 1221.103... approved by the Commission of Fine Arts and the NASA Administrator. It symbolizes NASA's role in... visual communications formerly reserved for the NASA Logotype. The NASA Insignia shall be used as set...
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Industrial and Systems Engineering Applications in NASA
Shivers, Charles H.
2006-01-01
A viewgraph presentation on the many applications of Industrial and Systems Engineering used for safe NASA missions is shown. The topics include: 1) NASA Information; 2) Industrial Engineering; 3) Systems Engineering; and 4) Major NASA Programs.
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NASA Science Engagement Through "Sky Art"
Bethea, K. L.; Damadeo, K.
2013-12-01
Sky Art is a NASA-funded online community where the public can share in the beauty of nature and the science behind it. At the center of Sky Art is a gallery of amateur sky photos submitted by users that are related to NASA Earth science mission research areas. Through their submissions, amateur photographers from around the world are engaged in the process of making observations, or taking pictures, of the sky just like many NASA science instruments. By submitting their pictures and engaging in the online community discussions and interactions with NASA scientists, users make the connection between the beauty of nature and atmospheric science. Sky Art is a gateway for interaction and information aimed at drawing excitement and interest in atmospheric phenomena including sunrises, sunsets, moonrises, moonsets, and aerosols, each of which correlates to a NASA science mission. Educating the public on atmospheric science topics in an informal way is a central goal of Sky Art. NASA science is included in the community through interaction from scientists, NASA images, and blog posts on science concepts derived from the images. Additionally, the website connects educators through the formal education pathway where science concepts are taught through activities and lessons that align with national learning standards. Sky Art was conceived as part of the Education and Public Outreach program of the SAGE III on ISS mission. There are currently three other NASA mission involved with Sky Art: CALIPSO, GPM, and CLARREO. This paper will discuss the process of developing the Sky Art online website, the challenges of growing a community of users, as well as the use of social media and mobile applications in science outreach and education.
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Technological Innovations from NASA
Pellis, Neal R.
2006-01-01
The challenge of human space exploration places demands on technology that push concepts and development to the leading edge. In biotechnology and biomedical equipment development, NASA science has been the seed for numerous innovations, many of which are in the commercial arena. The biotechnology effort has led to rational drug design, analytical equipment, and cell culture and tissue engineering strategies. Biomedical research and development has resulted in medical devices that enable diagnosis and treatment advances. NASA Biomedical developments are exemplified in the new laser light scattering analysis for cataracts, the axial flow left ventricular-assist device, non contact electrocardiography, and the guidance system for LASIK surgery. Many more developments are in progress. NASA will continue to advance technologies, incorporating new approaches from basic and applied research, nanotechnology, computational modeling, and database analyses.
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The successful test launch of two three-quarter ton satellites in the European Space Agency's (ESA) Ariane rocket last June firmly placed ESA in competition with NASA for the lucrative and growing satellite launching market. Under the auspices of the private (but largely French-government financed) Arianespace company, ESA is already attracting customers to its three-stage rocket by offering low costs.According to recent reports [Nature, 292, pp. 785 and 788, 1981], Arianespace has been able to win several U.S. customers away from NASA, including Southern Pacific Communications, Western Union, RCA, Satellite Television Corporation, and GTE. Nature [292, 1981] magazine in an article entitled ‘More Trouble for the Hapless Shuttle’ suggests that it will be possible for Ariane to charge lower prices for a launch than NASA, even with the space shuttle.
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14 CFR 1221.102 - Establishment of the NASA Seal.
2010-01-01
... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Establishment of the NASA Seal. 1221.102 Section 1221.102 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION THE NASA SEAL AND OTHER DEVICES, AND THE CONGRESSIONAL SPACE MEDAL OF HONOR NASA Seal, NASA Insignia, NASA Logotype, NASA...
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14 CFR 1221.106 - Establishment of the NASA Flag.
2010-01-01
... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Establishment of the NASA Flag. 1221.106 Section 1221.106 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION THE NASA SEAL AND OTHER DEVICES, AND THE CONGRESSIONAL SPACE MEDAL OF HONOR NASA Seal, NASA Insignia, NASA Logotype, NASA...
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14 CFR 1221.109 - Use of the NASA Seal.
2010-01-01
... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Use of the NASA Seal. 1221.109 Section 1221.109 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION THE NASA SEAL AND OTHER DEVICES, AND THE CONGRESSIONAL SPACE MEDAL OF HONOR NASA Seal, NASA Insignia, NASA Logotype, NASA Program...
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14 CFR 1221.113 - Use of the NASA Flags.
2010-01-01
... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Use of the NASA Flags. 1221.113 Section 1221.113 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION THE NASA SEAL AND OTHER DEVICES, AND THE CONGRESSIONAL SPACE MEDAL OF HONOR NASA Seal, NASA Insignia, NASA Logotype, NASA Program...
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Semantic-Web Technology: Applications at NASA
Ashish, Naveen
2004-01-01
We provide a description of work at the National Aeronautics and Space Administration (NASA) on building system based on semantic-web concepts and technologies. NASA has been one of the early adopters of semantic-web technologies for practical applications. Indeed there are several ongoing 0 endeavors on building semantics based systems for use in diverse NASA domains ranging from collaborative scientific activity to accident and mishap investigation to enterprise search to scientific information gathering and integration to aviation safety decision support We provide a brief overview of many applications and ongoing work with the goal of informing the external community of these NASA endeavors.
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Aye, Irving L M H; Rosario, Fredrick J; Powell, Theresa L; Jansson, Thomas
2015-10-13
Mothers with obesity or gestational diabetes mellitus have low circulating levels of adiponectin (ADN) and frequently deliver large babies with increased fat mass, who are susceptible to perinatal complications and to development of metabolic syndrome later in life. It is currently unknown if the inverse correlation between maternal ADN and fetal growth reflects a cause-and-effect relationship. We tested the hypothesis that ADN supplementation in obese pregnant dams improves maternal insulin sensitivity, restores normal placental insulin/mechanistic target of rapamycin complex 1 (mTORC1) signaling and nutrient transport, and prevents fetal overgrowth. Compared with dams on a control diet, female C57BL/6J mice fed an obesogenic diet before mating and throughout gestation had increased fasting serum leptin, insulin, and C-peptide, and reduced high-molecular-weight ADN at embryonic day (E) 18.5. Placental insulin and mTORC1 signaling was activated, peroxisome proliferator-activated receptor-α (PPARα) phosphorylation was reduced, placental transport of glucose and amino acids in vivo was increased, and fetal weights were 29% higher in obese dams. Maternal ADN infusion in obese dams from E14.5 to E18.5 normalized maternal insulin sensitivity, placental insulin/mTORC1 and PPARα signaling, nutrient transport, and fetal growth without affecting maternal fat mass. Using a mouse model with striking similarities to obese pregnant women, we demonstrate that ADN functions as an endocrine link between maternal adipose tissue and fetal growth by regulating placental function. Importantly, maternal ADN supplementation reversed the adverse effects of maternal obesity on placental function and fetal growth. Improving maternal ADN levels may serve as an effective intervention strategy to prevent fetal overgrowth caused by maternal obesity.
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Eclipse 2017: Through the Eyes of NASA
Mayo, Louis; NASA Heliophysics Education Consortium
2017-10-01
The August 21, 2017 total solar eclipse across America was, by all accounts, the biggest science education program ever carried out by NASA, significantly larger than the Curiosity Mars landing and the New Horizons Pluto flyby. Initial accounting estimates over two billion people reached and website hits exceeding five billion. The NASA Science Mission Directorate spent over two years planning and developing this enormous public education program, establishing over 30 official NASA sites along the path of totality, providing imagery from 11 NASA space assets, two high altitude aircraft, and over 50 high altitude balloons. In addition, a special four focal plane ground based solar telescope was developed in partnership with Lunt Solar Systems that observed and processed the eclipse in 6K resolution. NASA EDGE and NASA TV broadcasts during the entirity of totality across the country reached hundreds of millions, world wide.This talk will discuss NASA's strategy, results, and lessons learned; and preview some of the big events we plan to feature in the near future.
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Olórtegui, José; Espinoza, Marco; Espinoza, José; Montoya, Ysabel
2005-01-01
Tres mini preparaciones de extracción de ADN de algodón fueron comparadas en términos de calidad y rendimiento. El método de extracción de ADN usando CTAB fue el más eficiente (30 ug) en comparación con un kit comercial de extracción (20 ug) a partir de 100 mg de hojas cotiledonarias. La óptima calidad del ADN fue evaluada con las enzimas de restricción EcoRI y MseI. El ADN preparado será usado para iniciar el análisis de la biodiversidad genética del algodón peruano, usando marcadores mole...
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2011 NASA Range Safety Annual Report
Dumont, Alan G.
2012-01-01
Welcome to the 2011 edition of the NASA Range Safety Annual Report. Funded by NASA Headquarters, this report provides a NASA Range Safety overview for current and potential range users. As is typical with odd year editions, this is an abbreviated Range Safety Annual Report providing updates and links to full articles from the previous year's report. It also provides more complete articles covering new subject areas, summaries of various NASA Range Safety Program activities conducted during the past year, and information on several projects that may have a profound impact on the way business will be done in the future. Specific topics discussed and updated in the 2011 NASA Range Safety Annual Report include a program overview and 2011 highlights; Range Safety Training; Range Safety Policy revision; Independent Assessments; Support to Program Operations at all ranges conducting NASA launch/flight operations; a continuing overview of emerging range safety-related technologies; and status reports from all of the NASA Centers that have Range Safety responsibilities. Every effort has been made to include the most current information available. We recommend this report be used only for guidance and that the validity and accuracy of all articles be verified for updates. Once again the web-based format was used to present the annual report. We continually receive positive feedback on the web-based edition and hope you enjoy this year's product as well. As is the case each year, contributors to this report are too numerous to mention, but we thank individuals from the NASA Centers, the Department of Defense, and civilian organizations for their contributions. In conclusion, it has been a busy and productive year. I'd like to extend a personal Thank You to everyone who contributed to make this year a successful one, and I look forward to working with all of you in the upcoming year.
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NASA science communications strategy
1995-01-01
In 1994, the Clinton Administration issued a report, 'Science in the National Interest', which identified new national science goals. Two of the five goals are related to science communications: produce the finest scientists and engineers for the 21st century, and raise scientific and technological literacy of all Americans. In addition to the guidance and goals set forth by the Administration, NASA has been mandated by Congress under the 1958 Space Act to 'provide for the widest practicable and appropriate dissemination concerning its activities and the results thereof'. In addition to addressing eight Goals and Plans which resulted from a January 1994 meeting between NASA and members of the broader scientific, education, and communications community on the Public Communication of NASA's Science, the Science Communications Working Group (SCWG) took a comprehensive look at the way the Agency communicates its science to ensure that any changes the Agency made were long-term improvements. The SCWG developed a Science Communications Strategy for NASA and a plan to implement the Strategy. This report outlines a strategy from which effective science communications programs can be developed and implemented across the agency. Guiding principles and strategic themes for the strategy are provided, with numerous recommendations for improvement discussed within the respective themes of leadership, coordination, integration, participation, leveraging, and evaluation.
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Current and Future Parts Management at NASA
Sampson, Michael J.
2011-01-01
This presentation provides a high level view of current and future electronic parts management at NASA. It describes a current perspective of the new human space flight direction that NASA is beginning to take and how that could influence parts management in the future. It provides an overview of current NASA electronic parts policy and how that is implemented at the NASA flight Centers. It also describes some of the technical challenges that lie ahead and suggests approaches for their mitigation. These challenges include: advanced packaging, obsolescence and counterfeits, the global supply chain and Commercial Crew, a new direction by which NASA will utilize commercial launch vehicles to get astronauts to the International Space Station.
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78 FR 41804 - NASA Advisory Council; Meeting.
2013-07-11
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (13-077)] NASA Advisory Council; Meeting... Space Administration announces a meeting of the NASA Advisory Council (NAC). DATES: Wednesday, July 31... ADDRESSES: NASA Headquarters, Room 9H40, Program Review Center, 300 E Street SW., Washington, DC 20456 FOR...
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Standards of conduct for NASA employees
1987-01-01
'Standards of Conduct' for employees (14 CFR Part 1207) is set forth in this handbook and is hereby incorporated in the NASA Directives System. This handbook incorporates, for the convenience of NASA employees, the regulations now in effect prescribing standards of conduct for NASA employees. These regulations set forth the high ethical standards of conduct required of NASA employees in carrying out their duties and responsibilities. These regulations have been approved by the Office of Government Ethics, Office of Personnel Management. The regulations incorporated in this handbook were first published in the Federal Register on October 21, 1967 (32 FR 14648-14659); Part B concerning the acceptance of gifts, gratuities, or entertainment was extensively revised on January 19, 1976 (41 FR 2631-2633) to clarify and generally to restrict the exceptions to the general rule against the acceptance by a NASA employee from persons or firms doing or seeking business with NASA. Those regulations were updated on January 29, 1985 (50 FR 3887) to ensure conformity to the Ethics in Government Act of 1978 regarding the public financial disclosure statement. These regulations were published in the Federal Register on June 16, 1987 (52 FR 22755-764) and a correction was printed on Sept. 28, 1987 (52 FR 36234).
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NASA Occupational Health Program FY98 Self-Assessment
Brisbin, Steven G.
1999-01-01
The NASA Functional Management Review process requires that each NASA Center conduct self-assessments of each functional area. Self-Assessments were completed in June 1998 and results were presented during this conference session. During FY 97 NASA Occupational Health Assessment Team activities, a decision was made to refine the NASA Self-Assessment Process. NASA Centers were involved in the ISO registration process at that time and wanted to use the management systems approach to evaluate their occupational health programs. This approach appeared to be more consistent with NASA's management philosophy and would likely confer status needed by Senior Agency Management for the program. During FY 98 the Agency Occupational Health Program Office developed a revised self-assessment methodology based on the Occupational Health and Safety Management System developed by the American Industrial Hygiene Association. This process was distributed to NASA Centers in March 1998 and completed in June 1998. The Center Self Assessment data will provide an essential baseline on the status of OHP management processes at NASA Centers. That baseline will be presented to Enterprise Associate Administrators and DASHO on September 22, 1998 and used as a basis for discussion during FY 99 visits to NASA Centers. The process surfaced several key management system elements warranting further support from the Lead Center. Input and feedback from NASA Centers will be essential to defining and refining future self assessment efforts.
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NASA Applications of Molecular Nanotechnology
Globus, Al; Bailey, David; Han, Jie; Jaffe, Richard; Levit, Creon; Merkle, Ralph; Srivastava, Deepak
1998-01-01
Laboratories throughout the world are rapidly gaining atomically precise control over matter. As this control extends to an ever wider variety of materials, processes and devices, opportunities for applications relevant to NASA's missions will be created. This document surveys a number of future molecular nanotechnology capabilities of aerospace interest. Computer applications, launch vehicle improvements, and active materials appear to be of particular interest. We also list a number of applications for each of NASA's enterprises. If advanced molecular nanotechnology can be developed, almost all of NASA's endeavors will be radically improved. In particular, a sufficiently advanced molecular nanotechnology can arguably bring large scale space colonization within our grasp.
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Tse, S. C.; So, S. K.; Yeung, M. Y.; Lo, C. F.; Wen, S. W.; Chen, C. H.
2006-01-01
The charge transport properties of three tertiary-butyl (t-Bu) substituted anthracene derivatives (ADN), critical blue host materials for organic light-emitting diodes (OLEDs), have been investigated experimentally and computationally. From time-of-flight (TOF) measurements, all ADN compounds exhibit ambipolar characters. The hole and electron mobilities are in the range (1--5)× 10-7 cm2 V-1 s-1 under an external applied field of about 1 MV cm-1. Un-substituted ADN has the highest carrier mobilities while heavily t-Bu substituted ADN has the least. The electron and hole conducting properties of are consistent with ab initio calculation, which indicates that the frontier orbitals are localized mainly on the anthracene moiety. t-Bu substitutions in ADN increase the hopping path lengths among the molecules and hence reduce the electron and hole mobilities. The results demonstrate that t-Bu substitution is an effective means of engineering the conductivity of organic charge transporter for OLED applications.
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76 FR 4133 - NASA Advisory Council; Meeting
2011-01-24
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (11-007)] NASA Advisory Council; Meeting... Space Administration announces a meeting of the NASA Advisory Council. DATES: Thursday, February 10, 2011, 8 a.m.-5 p.m., Local Time. Friday, February 11, 2011, 8 a.m.-12 p.m., Local Time. ADDRESSES: NASA...
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75 FR 5629 - NASA Advisory Council; Meeting
2010-02-03
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-019)] NASA Advisory Council; Meeting... Space Administration announces a meeting of the NASA Advisory Council. DATES: Thursday, February 18, 2010, 9 a.m.-5 p.m. EST; Friday, February 19, 2010, 9 a.m.-1 p.m., EST. ADDRESSES: NASA Headquarters...
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75 FR 4875 - NASA Advisory Council; Meeting
2010-01-29
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-015)] NASA Advisory Council; Meeting... the NASA Advisory Council. This will be the first meeting of this Committee. DATES: February 17, 2010--10 a.m.-4 p.m. (EST). ADDRESSES: NASA Headquarters, 300 E Street, SW., Washington, DC, Room CD61. FOR...
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76 FR 41824 - NASA Advisory Council; Science Committee; Meeting
2011-07-15
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (11-068)] NASA Advisory Council; Science... Aeronautics and Space Administration (NASA) announces a meeting of the Science Committee of the NASA Advisory..., 2011, 7:30 a.m. to 11:30 a.m., Local Time. ADDRESSES: NASA Ames Research Center, NASA Ames Conference...
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Space astronomy and astrophysics program by NASA
Hertz, Paul L.
2014-07-01
The National Aeronautics and Space Administration recently released the NASA Strategic Plan 20141, and the NASA Science Mission Directorate released the NASA 2014 Science Plan3. These strategic documents establish NASA's astrophysics strategic objectives to be (i) to discover how the universe works, (ii) to explore how it began and evolved, and (iii) to search for life on planets around other stars. The multidisciplinary nature of astrophysics makes it imperative to strive for a balanced science and technology portfolio, both in terms of science goals addressed and in missions to address these goals. NASA uses the prioritized recommendations and decision rules of the National Research Council's 2010 decadal survey in astronomy and astrophysics2 to set the priorities for its investments. The NASA Astrophysics Division has laid out its strategy for advancing the priorities of the decadal survey in its Astrophysics 2012 Implementation Plan4. With substantial input from the astrophysics community, the NASA Advisory Council's Astrophysics Subcommittee has developed an astrophysics visionary roadmap, Enduring Quests, Daring Visions5, to examine possible longer-term futures. The successful development of the James Webb Space Telescope leading to a 2018 launch is an Agency priority. One important goal of the Astrophysics Division is to begin a strategic mission, subject to the availability of funds, which follows from the 2010 decadal survey and is launched after the James Webb Space Telescope. NASA is studying a Wide Field Infrared Survey Telescope as its next large astrophysics mission. NASA is also planning to partner with other space agencies on their missions as well as increase the cadence of smaller Principal Investigator led, competitively selected Astrophysics Explorers missions.
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NASA Education Recommendation Report - Education Design Team 2011
Pengra, Trish; Stofan, James
2011-01-01
NASA people are passionate about their work. NASA's missions are exciting to learners of all ages. And since its creation in 1958, NASA's people have been passionate about sharing their inspiring discoveries, research and exploration with students and educators. In May 2010, NASA administration chartered an Education Design Team composed of 12 members chosen from the Office of Education, NASA's Mission Directorates and Centers for their depth of knowledge and education expertise, and directed them to evaluate the Agency's program in the context of current trends in education. By improving NASA's educational offerings, he was confident that the Agency can play a leading role in inspiring student interest in science, technology, engineering and mathematics (STEM) as few other organizations can. Through its unique workforce, facilities, research and innovations, NASA can expand its efforts to engage underserved and underrepresented communities in science and mathematics. Through the Agency's STEM education efforts and science and exploration missions, NASA can help the United States successfully compete, prosper and be secure in the 21st century global community. After several months of intense effort, including meeting with education experts; reviewing Administration policies, congressional direction and education research; and seeking input from those passionate about education at NASA, the Education Design Team made six recommendations to improve the impact of NASA's Education Program: (1) Focus the NASA Education Program to improve its impact on areas of greatest national need (2) Identify and strategically manage NASA Education partnerships (3) Participate in National and State STEM Education policy discussions (4) Establish a structure to allow the Office of Education, Centers and Mission Directorates to implement a strategically integrated portfolio (5) Expand the charter of the Education Coordinating Committee to enable deliberate Education Program design (6
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NASA, NOAA administrators nominated
Richman, Barbara T.
President Ronald Reagan recently said he intended to nominate James Montgomery Beggs as NASA Administrator and John V. Byrne as NOAA Administrator. These two positions are key scientific posts that have been vacant since the start of the Reagan administration on January 20. The President also said he intends to nominate Hans Mark as NASA Deputy Administrator. At press time, Reagan had not designated his nominee for the director of the Office of Science and Technology Policy.
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NASA Risk Management Handbook. Version 1.0
Dezfuli, Homayoon; Benjamin, Allan; Everett, Christopher; Maggio, Gaspare; Stamatelatos, Michael; Youngblood, Robert; Guarro, Sergio; Rutledge, Peter; Sherrard, James; Smith, Curtis;
2011-01-01
The purpose of this handbook is to provide guidance for implementing the Risk Management (RM) requirements of NASA Procedural Requirements (NPR) document NPR 8000.4A, Agency Risk Management Procedural Requirements [1], with a specific focus on programs and projects, and applying to each level of the NASA organizational hierarchy as requirements flow down. This handbook supports RM application within the NASA systems engineering process, and is a complement to the guidance contained in NASA/SP-2007-6105, NASA Systems Engineering Handbook [2]. Specifically, this handbook provides guidance that is applicable to the common technical processes of Technical Risk Management and Decision Analysis established by NPR 7123.1A, NASA Systems Engineering Process and Requirements [3]. These processes are part of the \\Systems Engineering Engine. (Figure 1) that is used to drive the development of the system and associated work products to satisfy stakeholder expectations in all mission execution domains, including safety, technical, cost, and schedule. Like NPR 7123.1A, NPR 8000.4A is a discipline-oriented NPR that intersects with product-oriented NPRs such as NPR 7120.5D, NASA Space Flight Program and Project Management Requirements [4]; NPR 7120.7, NASA Information Technology and Institutional Infrastructure Program and Project Management Requirements [5]; and NPR 7120.8, NASA Research and Technology Program and Project Management Requirements [6]. In much the same way that the NASA Systems Engineering Handbook is intended to provide guidance on the implementation of NPR 7123.1A, this handbook is intended to provide guidance on the implementation of NPR 8000.4A. 1.2 Scope and Depth This handbook provides guidance for conducting RM in the context of NASA program and project life cycles, which produce derived requirements in accordance with existing systems engineering practices that flow down through the NASA organizational hierarchy. The guidance in this handbook is not meant
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NASA Schedule Management Handbook
2011-01-01
The purpose of schedule management is to provide the framework for time-phasing, resource planning, coordination, and communicating the necessary tasks within a work effort. The intent is to improve schedule management by providing recommended concepts, processes, and techniques used within the Agency and private industry. The intended function of this handbook is two-fold: first, to provide guidance for meeting the scheduling requirements contained in NPR 7120.5, NASA Space Flight Program and Project Management Requirements, NPR 7120.7, NASA Information Technology and Institutional Infrastructure Program and Project Requirements, NPR 7120.8, NASA Research and Technology Program and Project Management Requirements, and NPD 1000.5, Policy for NASA Acquisition. The second function is to describe the schedule management approach and the recommended best practices for carrying out this project control function. With regards to the above project management requirements documents, it should be noted that those space flight projects previously established and approved under the guidance of prior versions of NPR 7120.5 will continue to comply with those requirements until project completion has been achieved. This handbook will be updated as needed, to enhance efficient and effective schedule management across the Agency. It is acknowledged that most, if not all, external organizations participating in NASA programs/projects will have their own internal schedule management documents. Issues that arise from conflicting schedule guidance will be resolved on a case by case basis as contracts and partnering relationships are established. It is also acknowledged and understood that all projects are not the same and may require different levels of schedule visibility, scrutiny and control. Project type, value, and complexity are factors that typically dictate which schedule management practices should be employed.
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75 FR 4588 - NASA Advisory Council; Meeting
2010-01-28
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 10-011] NASA Advisory Council; Meeting... Committee of the NASA Advisory Council. This will be the first meeting of this Committee. DATES: February 11, 2010--11 a.m.-1 p.m. (EST). Meet-Me-Number: 1-877-613-3958; 2939943. ADDRESSES: NASA Headquarters, 300...
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77 FR 9997 - NASA Advisory Council; Meeting
2012-02-21
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (12-016)] NASA Advisory Council; Meeting... Space Administration announces a meeting of the NASA Advisory Council (NAC). DATES: Thursday, March 8, 2012, 8 a.m.-5 p.m., local time and Friday, March 9, 2012, 8 a.m.-12 p.m., local time. ADDRESSES: NASA...
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NASA's Planetary Science Missions and Participations
Daou, Doris; Green, James L.
2017-04-01
NASA's Planetary Science Division (PSD) and space agencies around the world are collaborating on an extensive array of missions exploring our solar system. Planetary science missions are conducted by some of the most sophisticated robots ever built. International collaboration is an essential part of what we do. NASA has always encouraged international participation on our missions both strategic (ie: Mars 2020) and competitive (ie: Discovery and New Frontiers) and other Space Agencies have reciprocated and invited NASA investigators to participate in their missions. NASA PSD has partnerships with virtually every major space agency. For example, NASA has had a long and very fruitful collaboration with ESA. ESA has been involved in the Cassini mission and, currently, NASA funded scientists are involved in the Rosetta mission (3 full instruments, part of another), BepiColombo mission (1 instrument in the Italian Space Agency's instrument suite), and the Jupiter Icy Moon Explorer mission (1 instrument and parts of two others). In concert with ESA's Mars missions NASA has an instrument on the Mars Express mission, the orbit-ground communications package on the Trace Gas Orbiter (launched in March 2016) and part of the DLR/Mars Organic Molecule Analyzer instruments going onboard the ExoMars Rover (to be launched in 2018). NASA's Planetary Science Division has continuously provided its U.S. planetary science community with opportunities to include international participation on NASA missions too. For example, NASA's Discovery and New Frontiers Programs provide U.S. scientists the opportunity to assemble international teams and design exciting, focused planetary science investigations that would deepen the knowledge of our Solar System. The PSD put out an international call for instruments on the Mars 2020 mission. This procurement led to the selection of Spain and Norway scientist leading two instruments and French scientists providing a significant portion of another
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NASA's Earth Science Data Systems Standards Process Experiences
Ullman, Richard E.; Enloe, Yonsook
2007-01-01
NASA has impaneled several internal working groups to provide recommendations to NASA management on ways to evolve and improve Earth Science Data Systems. One of these working groups is the Standards Process Group (SPC). The SPG is drawn from NASA-funded Earth Science Data Systems stakeholders, and it directs a process of community review and evaluation of proposed NASA standards. The working group's goal is to promote interoperability and interuse of NASA Earth Science data through broader use of standards that have proven implementation and operational benefit to NASA Earth science by facilitating the NASA management endorsement of proposed standards. The SPC now has two years of experience with this approach to identification of standards. We will discuss real examples of the different types of candidate standards that have been proposed to NASA's Standards Process Group such as OPeNDAP's Data Access Protocol, the Hierarchical Data Format, and Open Geospatial Consortium's Web Map Server. Each of the three types of proposals requires a different sort of criteria for understanding the broad concepts of "proven implementation" and "operational benefit" in the context of NASA Earth Science data systems. We will discuss how our Standards Process has evolved with our experiences with the three candidate standards.
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Curating NASA's Past, Present, and Future Extraterrestrial Sample Collections
McCubbin, F. M.; Allton, J. H.; Evans, C. A.; Fries, M. D.; Nakamura-Messenger, K.; Righter, K.; Zeigler, R. A.; Zolensky, M.; Stansbery, E. K.
2016-01-01
The Astromaterials Acquisition and Curation Office (henceforth referred to herein as NASA Curation Office) at NASA Johnson Space Center (JSC) is responsible for curating all of NASA's extraterrestrial samples. Under the governing document, NASA Policy Directive (NPD) 7100.10E "Curation of Extraterrestrial Materials", JSC is charged with "...curation of all extra-terrestrial material under NASA control, including future NASA missions." The Directive goes on to define Curation as including "...documentation, preservation, preparation, and distribution of samples for research, education, and public outreach." Here we describe some of the past, present, and future activities of the NASA Curation Office.
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Educational NASA Computational and Scientific Studies (enCOMPASS)
Memarsadeghi, Nargess
2013-01-01
Educational NASA Computational and Scientific Studies (enCOMPASS) is an educational project of NASA Goddard Space Flight Center aimed at bridging the gap between computational objectives and needs of NASA's scientific research, missions, and projects, and academia's latest advances in applied mathematics and computer science. enCOMPASS achieves this goal via bidirectional collaboration and communication between NASA and academia. Using developed NASA Computational Case Studies in university computer science/engineering and applied mathematics classes is a way of addressing NASA's goals of contributing to the Science, Technology, Education, and Math (STEM) National Objective. The enCOMPASS Web site at http://encompass.gsfc.nasa.gov provides additional information. There are currently nine enCOMPASS case studies developed in areas of earth sciences, planetary sciences, and astrophysics. Some of these case studies have been published in AIP and IEEE's Computing in Science and Engineering magazines. A few university professors have used enCOMPASS case studies in their computational classes and contributed their findings to NASA scientists. In these case studies, after introducing the science area, the specific problem, and related NASA missions, students are first asked to solve a known problem using NASA data and past approaches used and often published in a scientific/research paper. Then, after learning about the NASA application and related computational tools and approaches for solving the proposed problem, students are given a harder problem as a challenge for them to research and develop solutions for. This project provides a model for NASA scientists and engineers on one side, and university students, faculty, and researchers in computer science and applied mathematics on the other side, to learn from each other's areas of work, computational needs and solutions, and the latest advances in research and development. This innovation takes NASA science and
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Defining an Open Source Strategy for NASA
Mattmann, C. A.; Crichton, D. J.; Lindsay, F.; Berrick, S. W.; Marshall, J. J.; Downs, R. R.
2011-12-01
Over the course of the past year, we have worked to help frame a strategy for NASA and open source software. This includes defining information processes to understand open source licensing, attribution, commerciality, redistribution, communities, architectures, and interactions within the agency. Specifically we held a training session at the NASA Earth Science Data Systems Working Group meeting in Open Source software as it relates to the NASA Earth Science data systems enterprise, including EOSDIS, the Distributed Active Archive Centers (DAACs), ACCESS proposals, and the MEASURES communities, and efforts to understand how open source software can be both consumed and produced within that ecosystem. In addition, we presented at the 1st NASA Open Source Summit (OSS) and helped to define an agency-level strategy, a set of recommendations and paths forward for how to identify healthy open source communities, how to deal with issues such as contributions originating from other agencies, and how to search out talent with the right skills to develop software for NASA in the modern age. This talk will review our current recommendations for open source at NASA, and will cover the set of thirteen recommendations output from the NASA Open Source Summit and discuss some of their implications for the agency.
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Development of Risk Uncertainty Factors from Historical NASA Projects
Amer, Tahani R.
2011-01-01
NASA is a good investment of federal funds and strives to provide the best value to the nation. NASA has consistently budgeted to unrealistic cost estimates, which are evident in the cost growth in many of its programs. In this investigation, NASA has been using available uncertainty factors from the Aerospace Corporation, Air Force, and Booz Allen Hamilton to develop projects risk posture. NASA has no insight into the developmental of these factors and, as demonstrated here, this can lead to unrealistic risks in many NASA Programs and projects (P/p). The primary contribution of this project is the development of NASA missions uncertainty factors, from actual historical NASA projects, to aid cost-estimating as well as for independent reviews which provide NASA senior management with information and analysis to determine the appropriate decision regarding P/p. In general terms, this research project advances programmatic analysis for NASA projects.
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NASA Facts, The Viking Mission.
National Aeronautics and Space Administration, Washington, DC. Educational Programs Div.
Presented is one of a series of publications of National Aeronautics and Space Administration (NASA) facts about the exploration of Mars. The Viking mission to Mars, consisting of two unmanned NASA spacecraft launched in August and September, 1975, is described. A description of the spacecraft and their paths is given. A diagram identifying the…
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Enhancing Undergraduate Education with NASA Resources
Manning, James G.; Meinke, Bonnie; Schultz, Gregory; Smith, Denise Anne; Lawton, Brandon L.; Gurton, Suzanne; Astrophysics Community, NASA
2015-08-01
The NASA Astrophysics Science Education and Public Outreach Forum (SEPOF) coordinates the work of NASA Science Mission Directorate (SMD) Astrophysics EPO projects and their teams to bring cutting-edge discoveries of NASA missions to the introductory astronomy college classroom. Uniquely poised to foster collaboration between scientists with content expertise and educators with pedagogical expertise, the Forum has coordinated the development of several resources that provide new opportunities for college and university instructors to bring the latest NASA discoveries in astrophysics into their classrooms.To address the needs of the higher education community, the Astrophysics Forum collaborated with the astrophysics E/PO community, researchers, and introductory astronomy instructors to place individual science discoveries and learning resources into context for higher education audiences. The resulting products include two “Resource Guides” on cosmology and exoplanets, each including a variety of accessible resources. The Astrophysics Forum also coordinates the development of the “Astro 101” slide set series. The sets are five- to seven-slide presentations on new discoveries from NASA astrophysics missions relevant to topics in introductory astronomy courses. These sets enable Astronomy 101 instructors to include new discoveries not yet in their textbooks in their courses, and may be found at: https://www.astrosociety.org/education/resources-for-the-higher-education-audience/.The Astrophysics Forum also coordinated the development of 12 monthly “Universe Discovery Guides,” each featuring a theme and a representative object well-placed for viewing, with an accompanying interpretive story, strategies for conveying the topics, and supporting NASA-approved education activities and background information from a spectrum of NASA missions and programs. These resources are adaptable for use by instructors and may be found at: http://nightsky.jpl.nasa
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14 CFR 1206.401 - Location of NASA Information Centers.
2010-01-01
... Locator (URL) addresses are as follows: (1) (HQ) http://www.hq.nasa.gov/office/pao/FOIA/; (2) (ARC) http://george.arc.nasa.gov/dx/FOIA/elec.html; (3) (DFRC) http://www.dfrc.nasa.gov/FOIA/readroom.html; (4) (GRC) http://www.grc.nasa.gov/WWW/FOIA/ReadingRm.htm; (5) (GSFC) http://genesis.gsfc.nasa.gov//foia/read-rm...
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NASA Software Engineering Benchmarking Study
Rarick, Heather L.; Godfrey, Sara H.; Kelly, John C.; Crumbley, Robert T.; Wifl, Joel M.
2013-01-01
To identify best practices for the improvement of software engineering on projects, NASA's Offices of Chief Engineer (OCE) and Safety and Mission Assurance (OSMA) formed a team led by Heather Rarick and Sally Godfrey to conduct this benchmarking study. The primary goals of the study are to identify best practices that: Improve the management and technical development of software intensive systems; Have a track record of successful deployment by aerospace industries, universities [including research and development (R&D) laboratories], and defense services, as well as NASA's own component Centers; and Identify candidate solutions for NASA's software issues. Beginning in the late fall of 2010, focus topics were chosen and interview questions were developed, based on the NASA top software challenges. Between February 2011 and November 2011, the Benchmark Team interviewed a total of 18 organizations, consisting of five NASA Centers, five industry organizations, four defense services organizations, and four university or university R and D laboratory organizations. A software assurance representative also participated in each of the interviews to focus on assurance and software safety best practices. Interviewees provided a wealth of information on each topic area that included: software policy, software acquisition, software assurance, testing, training, maintaining rigor in small projects, metrics, and use of the Capability Maturity Model Integration (CMMI) framework, as well as a number of special topics that came up in the discussions. NASA's software engineering practices compared favorably with the external organizations in most benchmark areas, but in every topic, there were ways in which NASA could improve its practices. Compared to defense services organizations and some of the industry organizations, one of NASA's notable weaknesses involved communication with contractors regarding its policies and requirements for acquired software. One of NASA's strengths
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Communicating the Science from NASA's Astrophysics Missions
Hasan, Hashima; Smith, Denise A.
2015-01-01
Communicating science from NASA's Astrophysics missions has multiple objectives, which leads to a multi-faceted approach. While a timely dissemination of knowledge to the scientific community follows the time-honored process of publication in peer reviewed journals, NASA delivers newsworthy research result to the public through news releases, its websites and social media. Knowledge in greater depth is infused into the educational system by the creation of educational material and teacher workshops that engage students and educators in cutting-edge NASA Astrophysics discoveries. Yet another avenue for the general public to learn about the science and technology through NASA missions is through exhibits at museums, science centers, libraries and other public venues. Examples of the variety of ways NASA conveys the excitement of its scientific discoveries to students, educators and the general public will be discussed in this talk. A brief overview of NASA's participation in the International Year of Light will also be given, as well as of the celebration of the twenty-fifth year of the launch of the Hubble Space Telescope.
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Mars Sample Return: Do Australians trust NASA?
Joyce, S.; Tomkins, C. S.; Weinstein, P.
2008-09-01
Mars Sample Return (MSR) represents an important scientific goal in space exploration. Any sample return mission will be extremely challenging from a scientific, economic and technical standpoint. But equally testing, will be communicating with a public that may have a very different perception of the mission. A MSR mission will generate international publicity and it is vital that NASA acknowledge the nature and extent of public concern about the mission risks and, perhaps equally importantly, the public’s confidence in NASA’s ability to prepare for and manage these risks. This study investigated the level of trust in NASA in an Australian population sample, and whether this trust was dependent on demographic variables. Participants completed an online survey that explored their attitudes towards NASA and a MSR mission. The results suggested that people believe NASA will complete the mission successfully but have doubts as to whether NASA will be honest when communicating with the public. The most significant finding to emerge from this study was that confidence in NASA was significantly (p communication.
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NASA System Engineering Design Process
Roman, Jose
2011-01-01
This slide presentation reviews NASA's use of systems engineering for the complete life cycle of a project. Systems engineering is a methodical, disciplined approach for the design, realization, technical management, operations, and retirement of a system. Each phase of a NASA project is terminated with a Key decision point (KDP), which is supported by major reviews.
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NASA's EOSDIS, Trust and Certification
Ramapriyan, H. K.
2017-01-01
NASA's Earth Observing System Data and Information System (EOSDIS) has been in operation since August 1994, managing most of NASA's Earth science data from satellites, airborne sensors, filed campaigns and other activities. Having been designated by the Federal Government as a project responsible for production, archiving and distribution of these data through its Distributed Active Archive Centers (DAACs), the Earth Science Data and Information System Project (ESDIS) is responsible for EOSDIS, and is legally bound by the Office of Management and Budgets circular A-130, the Federal Records Act. It must follow the regulations of the National Institute of Standards and Technologies (NIST) and National Archive and Records Administration (NARA). It must also follow the NASA Procedural Requirement 7120.5 (NASA Space Flight Program and Project Management). All these ensure that the data centers managed by ESDIS are trustworthy from the point of view of efficient and effective operations as well as preservation of valuable data from NASA's missions. Additional factors contributing to this trust are an extensive set of internal and external reviews throughout the history of EOSDIS starting in the early 1990s. Many of these reviews have involved external groups of scientific and technological experts. Also, independent annual surveys of user satisfaction that measure and publish the American Customer Satisfaction Index (ACSI), where EOSDIS has scored consistently high marks since 2004, provide an additional measure of trustworthiness. In addition, through an effort initiated in 2012 at the request of NASA HQ, the ESDIS Project and 10 of 12 DAACs have been certified by the International Council for Science (ICSU) World Data System (WDS) and are members of the ICSUWDS. This presentation addresses questions such as pros and cons of the certification process, key outcomes and next steps regarding certification. Recently, the ICSUWDS and Data Seal of Approval (DSA) organizations
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Balboni, John A.; Gokcen, Tahir; Hui, Frank C. L.; Graube, Peter; Morrissey, Patricia; Lewis, Ronald
2015-01-01
The paper describes the consolidation of NASA's high powered arc-jet testing at a single location. The existing plasma arc-jet wind tunnels located at the Johnson Space Center were relocated to Ames Research Center while maintaining NASA's technical capability to ground-test thermal protection system materials under simulated atmospheric entry convective heating. The testing conditions at JSC were reproduced and successfully demonstrated at ARC through close collaboration between the two centers. New equipment was installed at Ames to provide test gases of pure nitrogen mixed with pure oxygen, and for future nitrogen-carbon dioxide mixtures. A new control system was custom designed, installed and tested. Tests demonstrated the capability of the 10 MW constricted-segmented arc heater at Ames meets the requirements of the major customer, NASA's Orion program. Solutions from an advanced computational fluid dynamics code were used to aid in characterizing the properties of the plasma stream and the surface environment on the calorimeters in the supersonic flow stream produced by the arc heater.
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NASA's Scientific Visualization Studio
Mitchell, Horace G.
2003-01-01
Since 1988, the Scientific Visualization Studio(SVS) at NASA Goddard Space Flight Center has produced scientific visualizations of NASA s scientific research and remote sensing data for public outreach. These visualizations take the form of images, animations, and end-to-end systems and have been used in many venues: from the network news to science programs such as NOVA, from museum exhibits at the Smithsonian to White House briefings. This presentation will give an overview of the major activities and accomplishments of the SVS, and some of the most interesting projects and systems developed at the SVS will be described. Particular emphasis will be given to the practices and procedures by which the SVS creates visualizations, from the hardware and software used to the structures and collaborations by which products are designed, developed, and delivered to customers. The web-based archival and delivery system for SVS visualizations at svs.gsfc.nasa.gov will also be described.
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NASA spinoffs to energy and the environment
Gilbert, Ray L.; Lehrman, Stephen A.
1989-01-01
Thousands of aerospace innovations have found their way into everyday use, and future National Aeronautics and Space Administration (NASA) missions promise to provide many more spinoff opportunities. Each spinoff has contributed some measure of benefit to the national economy, productivity, or lifestyle. In total, these spinoffs represent a substantial dividend on the national investment in aerospace research. Along with examples of the many terrestrial applications of NASA technology to energy and the environment, this paper presents the mechanisms by which NASA promotes technology transfer. Also discussed are new NASA initiatives in superconductivity research, global warming, and aeropropulsion.
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Adiponectin and adiponectin receptor 1 overexpression enhance inflammatory bowel disease.
Peng, Yu-Ju; Shen, Tang-Long; Chen, Yu-Shan; Mersmann, Harry John; Liu, Bing-Hsien; Ding, Shih-Torng
2018-03-14
Adiponectin (ADN) is an adipokine derived from adipocytes. It binds to adiponectin receptor 1 and 2 (AdipoR1 and R2) to exert its function in regulating whole-body energy homeostasis and inflammatory responses. However, the role of ADN-AdipoR1 signaling in intestinal inflammation is controversial, and its role in the regulation of neutrophils is still unclear. Our goal was to clarify the role of AdipoR1 signaling in colitis and the effects on neutrophils. We generated porcine AdipoR1 transgenic mice (pAdipoR1 mice) and induced murine colitis using dextran sulfate sodium (DSS) to study the potential role of AdipoR1 in inflammatory bowel disease. We also treated a THP-1 macrophage and a HT-29 colon epithelial cell line with ADN recombinant protein to study the effects of ADN on inflammation. After inducing murine colitis, pAdipoR1 mice developed more severe symptoms than wild-type (WT) mice. Treatment with ADN increased the expression of pro-inflammatory factors in THP-1 and HT-29 cells. Moreover, we also observed that the expression of cyclooxygenase2 (cox2), neutrophil chemokines (CXCL1, CXCL2 and CXCL5), and the infiltration of neutrophils were increased in the colon of pAdipoR1 mice. Our study showed that ADN-AdipoR1 signaling exacerbated colonic inflammation through two possible mechanisms. First, ADN-AdipoR1 signaling increased pro-inflammatory factors. Second, AdipoR1 enhanced neutrophil chemokine expression and recruited neutrophils into the colonic tissue to increase inflammation.
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The Crucial Role of Additive Manufacturing at NASA
Vickers, John
2016-01-01
At NASA, the first steps of the Journey to Mars are well underway with the development of NASA's next generation launch system and investments in research and technologies that should increase the affordability, capability, and safety of exploration activities. Additive Manufacturing presents a disruptive opportunity for NASA to design and manufacture hardware with new materials at dramatically reduced cost and schedule. Opportunities to incorporate additive manufacturing align very well with NASA missions and with most NASA programs related to space, science, and aeronautics. The Agency also relies on many partnerships with other government agencies, industry and academia.
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Developing an Open Source Option for NASA Software
Moran, Patrick J.; Parks, John W. (Technical Monitor)
2003-01-01
We present arguments in favor of developing an Open Source option for NASA software; in particular we discuss how Open Source is compatible with NASA's mission. We compare and contrast several of the leading Open Source licenses, and propose one - the Mozilla license - for use by NASA. We also address some of the related issues for NASA with respect to Open Source. In particular, we discuss some of the elements in the External Release of NASA Software document (NPG 2210.1A) that will likely have to be changed in order to make Open Source a reality withm the agency.
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Dezfuli, Homayoon
2010-01-01
This slide presentation reviews the evolution of risk management (RM) at NASA. The aim of the RM approach at NASA is to promote an approach that is heuristic, proactive, and coherent across all of NASA. Risk Informed Decision Making (RIDM) is a decision making process that uses a diverse set of performance measures along with other considerations within a deliberative process to inform decision making. RIDM is invoked for key decisions such as architecture and design decisions, make-buy decisions, and budget reallocation. The RIDM process and how it relates to the continuous Risk Management (CRM) process is reviewed.
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NASA Education: Yesterday's Dream...Today's Vision...Tomorrow's Hope
Winterton, Joyce L.
2010-01-01
For 50 years, NASA's journeys into air and space have developed humankind's understanding of the universe, advanced technology breakthroughs, enhanced air travel safety and security, and expanded the frontiers of scientific research. These accomplishments share a common genesis: education. Education is a fundamental element of NASA's activities, reflecting a balanced and diverse portfolio of: Elementary and Secondary Education, Higher Education, e-Education, Informal Education, and Minority University Research and Education Programs (MUREP). Previous experience has shown that implementing exciting and compelling NASA missions are critical to inspiring the next generation of explorers, innovators, and leaders. Through partnerships with the Agency's Mission Directorates, other federal agencies, private industries, scientific research, and education/academic organizations, NASA's unique mission and education initiatives (content, people, and facilities) are helping to spark student interest and to guide them toward careers in science, technology, engineering, and mathematics (STEM). NASA continues to inspire the next generation of explorers, innovators, and future leaders through its educational investments, which are designed to: (1) Strengthen NASA and the Nation's future workforce -- NASA will identify and develop the critical skills and capabilities needed to ensure achievement of exploration, science, and aeronautics. (2) Attract and retain students in STEM disciplines through a progression of educational opportunities for students, teachers, and faculty -- To compete effectively for the minds, imaginations, and career ambitions of America's young people, NASA will focus on engaging and retaining students in STEM education programs to encourage their pursuit of educational disciplines critical to NASA's future engineering, scientific, and technical missions. 3. Engage Americans in NASA's mission -- NASA will build strategic partnerships and links between formal
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NASA Astrophysics E/PO Impact: NASA SOFIA AAA Program Evaluation Results
Harman, Pamela; Backman, Dana E.; Clark, Coral; Inverness Research Sofia Aaa Evaluation Team, Wested Sofia Aaa Evaluation Team
2015-01-01
SOFIA is an airborne observatory, studying the universe at infrared wavelengths, capable of making observations that are impossible for even the largest and highest ground-based telescopes. SOFIA also inspires the development of new scientific instrumentation and fosters the education of young scientists and engineers.SOFIA is an 80% - 20% partnership of NASA and the German Aerospace Center (DLR), consisting of an extensively modified Boeing 747SP aircraft carrying a reflecting telescope with an effective diameter of 2.5 meters (100 inches). The SOFIA aircraft is based at NASA Armstrong Flight Research Center, Building 703, in Palmdale, California. The Science Program and Outreach Offices are located at NASA Ames Research center. SOFIA is a program in NASA's Science Mission Directorate, Astrophysics Division.Data will be collected to study many different kinds of astronomical objects and phenomena, including star cycles, solar system formation, identification of complex molecules in space, our solar system, galactic dust, nebulae and ecosystems.Airborne Astronomy Ambassador (AAA) Program:The SOFIA Education and Communications program exploits the unique attributes of airborne astronomy to contribute to national goals for the reform of science, technology, engineering, and math (STEM) education, and to elevate public scientific and technical literacy.The AAA effort is a professional development program aspiring to improve teaching, inspire students, and inform the community. To date, 55 educators from 21 states; Cycles 0, 1 and 2; have completed their astronomy professional development and their SOFIA science flight experience. Evaluation has confirmed the program's positive impact on the teacher participants, on their students, and in their communities. The inspirational experience has positively impacted their practice and career trajectory. AAAs have incorporated content knowledge and specific components of their experience into their curricula, and have given
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NASA Goddard Thermal Technology Overview 2016
Butler, Dan; Swanson, Ted
2016-01-01
This presentation summarizes the current plans and efforts at NASA Goddard to develop new thermal control technology for anticipated future missions. It will also address some of the programmatic developments currently underway at NASA, especially with respect to the NASA Technology Development Program. The effects of the recently enacted FY 16 NASA budget, which includes a sizeable increase, will also be addressed. While funding for basic technology development is still tight, significant efforts are being made in direct support of flight programs. Thermal technology implementation on current flight programs will be reviewed, and the recent push for Cube-sat mission development will also be addressed. Many of these technologies also have broad applicability to DOD, DOE, and commercial programs. Partnerships have been developed with the Air Force, Navy, and various universities to promote technology development. In addition, technology development activities supported by internal research and development (IRAD) program and the Small Business Innovative Research (SBIR) program are reviewed in this presentation. Specific technologies addressed include; two-phase systems applications and issues on NASA missions, latest developments of electro-hydrodynamically pumped systems, Atomic Layer Deposition (ALD), Micro-scale Heat Transfer, and various other research activities.
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NASA Goddard Thermal Technology Overview 2018
Butler, Dan; Swanson, Ted
2018-01-01
This presentation summarizes the current plans and efforts at NASA/Goddard to develop new thermal control technology for anticipated future missions. It will also address some of the programmatic developments currently underway at NASA, especially with respect to the NASA Technology Development Program. The effects of the recently submitted NASA budget will also be addressed. While funding for basic technology development is still tight, significant efforts are being made in direct support of flight programs. Thermal technology Implementation on current flight programs will be reviewed, and the recent push for Cube-sat mission development will also be addressed. Many of these technologies also have broad applicability to DOD, DOE, and commercial programs. Partnerships have been developed with the Air Force, Navy, and various universities to promote technology development. In addition, technology development activities supported by internal research and development (IRAD) program and the Small Business Innovative Research (SBIR) program are reviewed in this presentation. Specific technologies addressed include; two-phase systems applications and issues on NASA missions, latest developments of thermal control coatings, Atomic Layer Deposition (ALD), Micro-scale Heat Transfer, and various other research activities.
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NASA university program management information system, FY 1985
1985-01-01
The University Program Report provides current information and related statistics for approximately 4200 grants/contracts/cooperative agreements active during the reporting period. NASA Field Centers and certain Headquarters Program Offices provide funds for those research and development activities in universities which contribute to the mission needs of that particular NASA element. This annual report is one means of documenting the NASA-University relationship, frequently denoted, collectively, as NASA's University Program.
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NASA university program management information system, FY 1994
1994-01-01
The University Program report, Fiscal Year 1994, provides current information and related statistics for 7841 grants/contracts/cooperative agreements active during the reporting period. NASA field centers and certain Headquarters program offices provide funds for those activities in universities which contribute to the mission needs of that particular NASA element. This annual report is one means of documenting the NASA-university relationship, frequently denoted, collectively, as NASA's University Program.
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NASA University Program Management Information System: FY 1995
1995-01-01
The University Program Report, Fiscal Year 1995, provides current information and related statistics for grants/contracts/cooperative agreements active during the report period. NASA field centers and certain Headquarters program offices provide funds for those R&D activities in universities which contribute to the mission needs of that particular NASA element. This annual report is one means of documenting the NASA-university relationship, frequently denoted, collectively, as NASA's University Program.
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NASA university program management information system, FY 1986
1986-01-01
The University Program Report provides current information and related statistics for approximately 4300 grants/contracts/cooperative agreements active during the report period. NASA Field centers and certain Headquarters Program Offices provide funds for those R&D activities in universities which contribute to the mission needs of that particular NASA element. This annual report is one means of documenting the NASA-university relationship, frequently denoted, collectively, as NASA's University Program.
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NASA University program management information system, FY 1993
1993-01-01
The University Program Report, Fiscal Year 1993, provides current information and related statistics for 7682 grants/contracts/cooperative agreements active during the report period. NASA field centers and certain Headquarters program offices provide funds for those R&D activities in universities which contribute to the mission needs of that particular NASA element. This annual report is one means of documenting the NASA-university relationship, frequently denoted, collectively, as NASA's University Program.
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Garg, Sanjay
2015-01-01
The Intelligent Control and Autonomy Branch (ICA) at NASA (National Aeronautics and Space Administration) Glenn Research Center (GRC) in Cleveland, Ohio, is leading and participating in various projects in partnership with other organizations within GRC and across NASA, the U.S. aerospace industry, and academia to develop advanced controls and health management technologies that will help meet the goals of the NASA Aeronautics Research Mission Directorate (ARMD) Programs. These efforts are primarily under the various projects under the Advanced Air Vehicles Program (AAVP), Airspace Operations and Safety Program (AOSP) and Transformative Aeronautics Concepts Program (TAC). The ICA Branch is focused on advancing the state-of-the-art of aero-engine control and diagnostics technologies to help improve aviation safety, increase efficiency, and enable operation with reduced emissions. This paper describes the various ICA research efforts under the NASA Aeronautics Research Mission Programs with a summary of motivation, background, technical approach, and recent accomplishments for each of the research tasks.
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The 2004 NASA Faculty Fellowship Program Research Reports
Pruitt, J. R.; Karr, G.; Freeman, L. M.; Hassan, R.; Day, J. B. (Compiler)
2005-01-01
This is the administrative report for the 2004 NASA Faculty Fellowship Program (NFFP) held at the George C. Marshall Space Flight Center (MSFC) for the 40th consecutive year. The NFFP offers science and engineering faculty at U.S. colleges and universities hands-on exposure to NASA s research challenges through summer research residencies and extended research opportunities at participating NASA research Centers. During this program, fellows work closely with NASA colleagues on research challenges important to NASA's strategic enterprises that are of mutual interest to the fellow and the Center. The nominal starting and .nishing dates for the 10-week program were June 1 through August 6, 2004. The program was sponsored by NASA Headquarters, Washington, DC, and operated under contract by The University of Alabama, The University of Alabama in Huntsville, and Alabama A&M University. In addition, promotion and applications are managed by the American Society for Engineering Education (ASEE) and assessment is completed by Universities Space Research Association (USRA). The primary objectives of the NFFP are to: Increase the quality and quantity of research collaborations between NASA and the academic community that contribute to the Agency s space aeronautics and space science mission. Engage faculty from colleges, universities, and community colleges in current NASA research and development. Foster a greater public awareness of NASA science and technology, and therefore facilitate academic and workforce literacy in these areas. Strengthen faculty capabilities to enhance the STEM workforce, advance competition, and infuse mission-related research and technology content into classroom teaching. Increase participation of underrepresented and underserved faculty and institutions in NASA science and technology.
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Eclipse Across America: Through the Eyes of NASA
Young, C. Alex; Heliophysics Education Consortium
2018-01-01
Monday, August 21, 2017, marked the first total solar eclipse to cross the continental United States coast-to-coast in almost a century. NASA scientists and educators, working alongside many partners, were spread across the entire country, both inside and outside the path of totality. Like many other organizations, NASA prepared for this eclipse for several years. The August 21 eclipse was NASA's biggest media event in recent history, and was made possible by the work of thousands of volunteers, collaborators and NASA employees. The agency supported science, outreach, and media communications activities along the path of totality and across the country. This culminated in a 3 ½-hour broadcast from Charleston, SC, showcasing the sights and sounds of the eclipse – starting with the view from a plane off the coast of Oregon and ending with images from the International Space Station as the Moon's inner shadow left the US East Coast. Along the way, NASA shared experiments and research from different groups of scientists, including 11 NASA-supported studies, 50+ high-altitude balloon launches, and 12 NASA and partner space-based assets. This talk shares the timeline of this momentous event from NASA's perspective, describing outreach successes and providing a glimpse at some of the science results available and yet to come.
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NASA Office of Small and Disadvantaged Business Utilization
2001-01-01
The Office of Small and Disadvantaged Business Utilization (OSDBU) within NASA promotes the utilization of small, disadvantaged, and women-owned small businesses in compliance with Federal laws, regulations, and policies. We assist such firms in obtaining contracts and subcontracts with NASA and its prime contractors. The OSDBU also facilitates the participation of small businesses in NASA's technology transfer and commercialization activities. Our driving philosophy is to consider small businesses as our products. Our customers are the NASA Enterprises, Field Centers, Functional Staff Offices, major prime contractors, and other large institutions. We hone the skills of our products to make them marketable to our customers in the performance of NASA missions.
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The NASA Integrated Information Technology Architecture
Baldridge, Tim
1997-01-01
This document defines an Information Technology Architecture for the National Aeronautics and Space Administration (NASA), where Information Technology (IT) refers to the hardware, software, standards, protocols and processes that enable the creation, manipulation, storage, organization and sharing of information. An architecture provides an itemization and definition of these IT structures, a view of the relationship of the structures to each other and, most importantly, an accessible view of the whole. It is a fundamental assumption of this document that a useful, interoperable and affordable IT environment is key to the execution of the core NASA scientific and project competencies and business practices. This Architecture represents the highest level system design and guideline for NASA IT related activities and has been created on the authority of the NASA Chief Information Officer (CIO) and will be maintained under the auspices of that office. It addresses all aspects of general purpose, research, administrative and scientific computing and networking throughout the NASA Agency and is applicable to all NASA administrative offices, projects, field centers and remote sites. Through the establishment of five Objectives and six Principles this Architecture provides a blueprint for all NASA IT service providers: civil service, contractor and outsourcer. The most significant of the Objectives and Principles are the commitment to customer-driven IT implementations and the commitment to a simpler, cost-efficient, standards-based, modular IT infrastructure. In order to ensure that the Architecture is presented and defined in the context of the mission, project and business goals of NASA, this Architecture consists of four layers in which each subsequent layer builds on the previous layer. They are: 1) the Business Architecture: the operational functions of the business, or Enterprise, 2) the Systems Architecture: the specific Enterprise activities within the context
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78 FR 41115 - NASA Advisory Council; Science Committee; Meeting
2013-07-09
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-074] NASA Advisory Council; Science... Aeronautics and Space Administration (NASA) announces a meeting of the Science Committee of the NASA Advisory... Time. ADDRESSES: NASA Headquarters, Room 7H45, 300 E Street SW., Washington, DC 20546. FOR FURTHER...
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Continuous Risk Management at NASA
Hammer, Theodore F.; Rosenberg, Linda
1999-01-01
NPG 7120.5A, "NASA Program and Project Management Processes and Requirements" enacted in April, 1998, requires that "The program or project manager shall apply risk management principles..." The Software Assurance Technology Center (SATC) at NASA GSFC has been tasked with the responsibility for developing and teaching a systems level course for risk management that provides information on how to comply with this edict. The course was developed in conjunction with the Software Engineering Institute at Carnegie Mellon University, then tailored to the NASA systems community. This presentation will briefly discuss the six functions for risk management: (1) Identify the risks in a specific format; (2) Analyze the risk probability, impact/severity, and timeframe; (3) Plan the approach; (4) Track the risk through data compilation and analysis; (5) Control and monitor the risk; (6) Communicate and document the process and decisions. This risk management structure of functions has been taught to projects at all NASA Centers and is being successfully implemented on many projects. This presentation will give project managers the information they need to understand if risk management is to be effectively implemented on their projects at a cost they can afford.
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Bailey, Brandon
2015-01-01
The Space Data Link Security (SDLS) Protocol is a Consultative Committee for Space Data Systems (CCSDS) standard which extends the known Data Link protocols to secure data being sent over a space link by providing confidentiality and integrity services. This plan outlines the approach by National Aeronautics Space Administration (NASA) in performing testing of the SDLS protocol using a prototype based on an existing NASA missions simulator.
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NASA's Astronant Family Support Office
Beven, Gary; Curtis, Kelly D.; Holland, Al W.; Sipes, Walter; VanderArk, Steve
2014-01-01
During the NASA-Mir program of the 1990s and due to the challenges inherent in the International Space Station training schedule and operations tempo, it was clear that a special focus on supporting families was a key to overall mission success for the ISS crewmembers pre-, in- and post-flight. To that end, in January 2001 the first Family Services Coordinator was hired by the Behavioral Health and Performance group at NASA JSC and matrixed from Medical Operations into the Astronaut Office's organization. The initial roles and responsibilities were driven by critical needs, including facilitating family communication during training deployments, providing mission-specific and other relevant trainings for spouses, serving as liaison for families with NASA organizations such as Medical Operations, NASA management and the Astronaut Office, and providing assistance to ensure success of an Astronaut Spouses Group. The role of the Family Support Office (FSO) has modified as the ISS Program matured and the needs of families changed. The FSO is currently an integral part of the Astronaut Office's ISS Operations Branch. It still serves the critical function of providing information to families, as well as being the primary contact for US and international partner families with resources at JSC. Since crews launch and return on Russian vehicles, the FSO has the added responsibility for coordinating with Flight Crew Operations, the families, and their guests for Soyuz launches, landings, and Direct Return to Houston post-flight. This presentation will provide a summary of the family support services provided for astronauts, and how they have changed with the Program and families the FSO serves. Considerations for future FSO services will be discussed briefly as NASA proposes one year missions and beyond ISS missions. Learning Objective: 1) Obtain an understanding of the reasons a Family Support Office was important for NASA. 2) Become familiar with the services provided for
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NASA Missions Inspire Online Video Games
2012-01-01
Fast forward to 2035. Imagine being part of a community of astronauts living and working on the Moon. Suddenly, in the middle of just another day in space, a meteorite crashes into the surface of the Moon, threatening life as you know it. The support equipment that provides oxygen for the entire community has been compromised. What would you do? While this situation is one that most people will never encounter, NASA hopes to place students in such situations - virtually - to inspire, engage, and educate about NASA technologies, job opportunities, and the future of space exploration. Specifically, NASA s Learning Technologies program, part of the Agency s Office of Education, aims to inspire and motivate students to pursue careers in the science, technology, engineering, and math (STEM) disciplines through interactive technologies. The ultimate goal of these educational programs is to support the growth of a pool of qualified scientific and technical candidates for future careers at places like NASA. STEM education has been an area of concern in the United States; according to the results of the 2009 Program for International Student Assessment, 23 countries had higher average scores in mathematics literacy than the United States. On the science literacy scale, 18 countries had higher average scores. "This is part of a much bigger picture of trying to grow skilled graduates for places like NASA that will want that technical expertise," says Daniel Laughlin, the Learning Technologies project manager at Goddard Space Flight Center. "NASA is trying to increase the number of students going into those fields, and so are other government agencies."
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78 FR 20357 - NASA Advisory Council; Science Committee; Meeting
2013-04-04
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-037] NASA Advisory Council; Science... Aeronautics and Space Administration (NASA) announces a meeting of the Science Committee of the NASA Advisory...:30 a.m. to 3:00 p.m., Local Time. ADDRESSES: NASA Headquarters, 300 E Street SW., Room 6H45...
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77 FR 38093 - NASA Advisory Council; Science Committee; Meeting
2012-06-26
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-046] NASA Advisory Council; Science... Aeronautics and Space Administration (NASA) announces a meeting of the Science Committee of the NASA Advisory.... to 2:30 p.m., local time. ADDRESSES: NASA Goddard Space Flight Center (GSFC), Building 1, Room E100E...
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76 FR 17158 - NASA Advisory Council; Science Committee; Meeting
2011-03-28
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (11-026)] NASA Advisory Council; Science... Aeronautics and Space Administration (NASA) announces a meeting of the Science Committee of the NASA Advisory....m. to 2 p.m., Local Time. ADDRESSES: NASA Headquarters, 300 E Street, SW., Room 5H45, Washington, DC...
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78 FR 67202 - NASA Advisory Council; Science Committee; Meeting
2013-11-08
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: 13-131] NASA Advisory Council; Science... Aeronautics and Space Administration (NASA) announces a meeting of the Science Committee of the NASA Advisory..., 2013, 8:30 a.m. to 3:00 p.m., Local Time. ADDRESSES: This meeting will take place at NASA Headquarters...
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Anbari, Allison Brandt; Vogelsmeier, Amy
2018-05-01
Associate Degree in Nursing (ADN)-to-Bachelor of Science in Nursing (BSN) programs are designed to advance the ADN-prepared RNs' clinical reasoning and analytical skills. However, little is known about exactly how their BSN education may improve their clinical practice, specifically in the area of patient safety. During semi-structured one-to-one interviews, ADN-to-BSN graduates were asked about their educational process and the perceived affect their education made on their ability to keep patients safe. Content analysis were used to identify emerging themes and categories. Three themes emerged from the data: (a) an unaltered approach to keeping patients safe, (b) experience as an ADN matters, and (c) BSN degree as a stepping stone. The call to increase the number of BSN-prepared nurses at the bedside is supported in the evidence and noteworthy of pursuit. However, as ADN-to-BSN programs increase in numbers to meet this demand, the outcomes of graduates need to be considered. [J Nurs Educ. 2018;57(5):300-303.]. Copyright 2018, SLACK Incorporated.
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NASA's Contribution to Global Space Geodesy Networks
Bosworth, John M.
1999-01-01
The NASA Space Geodesy program continues to be a major provider of space geodetic data for the international earth science community. NASA operates high performance Satellite Laser Ranging (SLR), Very Long Baseline Interferometry (VLBI) and Global Positioning System (GPS) ground receivers at well over 30 locations around the world and works in close cooperation with space geodetic observatories around the world. NASA has also always been at the forefront in the quest for technical improvement and innovation in the space geodesy technologies to make them even more productive, accurate and economical. This presentation will highlight the current status of NASA's networks; the plans for partnerships with international groups in the southern hemisphere to improve the geographic distribution of space geodesy sites and the status of the technological improvements in SLR and VLBI that will support the new scientific thrusts proposed by interdisciplinary earth scientists. In addition, the expanding role of the NASA Space geodesy data archive, the CDDIS will be described.
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ECHO Responds to NASA's Earth Science User Community
Pfister, Robin; Ullman, Richard; Wichmann, Keith; Perkins, Dorothy C. (Technical Monitor)
2001-01-01
Over the past decade NASA has designed, built, evolved, and operated the Earth Observing System Data and Information System (EOSDIS) Information Management System (IMS) in order to provide user access to NASA's Earth Science data holdings. During this time revolutionary advances in technology have driven changes in NASA's approach to providing an IMS service. This paper will describe NASA's strategic planning and approach to build and evolve the EOSDIS IMS and to serve the evolving needs of NASA's Earth Science community. It discusses the original strategic plan and how lessons learned help to form a new plan, a new approach and a new system. It discusses the original technologies and how they have evolved to today.
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NASA's Interests in Bioregenerative Life Support
Wheeler, Raymond M.
2018-01-01
NASA and other space agencies and around the world have had long-standing interest in using plants and biological approaches for regenerative life support. In particular, NASA's Kennedy Space Center, has conducted research in this area for over 30 years. One unique aspect to this testing was NASA's Biomass Production Chamber, which had four vertically stacked growing shelves inside a large, 113 cubic meter chamber. This was perhaps one of the first working examples of a vertical agriculture system in the world. A review of some of this research along with some of the more salient findings will be presented.
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In Brief: NASA Advisory Council structure
Showstack, Randy
2009-11-01
NASA Administrator Charles Bolden has added four new committees to the NASA Advisory Council in the areas of commercial space, education and public outreach, information technology infrastructure, and technology and innovation, the agency announced on 2 November. Other committees are in the areas of aeronautics; audit, finance, and analysis; exploration; science; and space operations. The council, which provides advice and makes recommendations to the administrator about agency programs, policies, plans, financial controls, and other matters, holds its next meeting on 18-19 February 2010. For more information, visit http://www.nasa.gov/offices/nac/home/index.html.
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Des Marais, David J.; Allamandola, Louis J.; Benner, Steven A.; Boss, Alan P.; Deamer, David; Falkowski, Paul G.; Farmer, Jack D.; Hedges, S. Blair; Jakosky, Bruce M.; Knoll, Andrew H.;
2003-01-01
The NASA Astrobiology Roadmap provides guidance for research and technology development across the NASA enterprises that encompass the space, Earth, and biological sciences. The ongoing development of astrobiology roadmaps embodies the contributions of diverse scientists and technologists from government, universities, and private institutions. The Roadmap addresses three basic questions: How does life begin and evolve, does life exist elsewhere in the universe, and what is the future of life on Earth and beyond? Seven Science Goals outline the following key domains of investigation: understanding the nature and distribution of habitable environments in the universe, exploring for habitable environments and life in our own solar system, understanding the emergence of life, determining how early life on Earth interacted and evolved with its changing environment, understanding the evolutionary mechanisms and environmental limits of life, determining the principles that will shape life in the future, and recognizing signatures of life on other worlds and on early Earth. For each of these goals, Science Objectives outline more specific high-priority efforts for the next 3-5 years. These 18 objectives are being integrated with NASA strategic planning.
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NASA Goddard Thermal Technology Overview 2017
Butler, Dan; Swanson, Ted
2017-01-01
This presentation summarizes the current plans and efforts at NASA Goddard to develop new thermal control technology for anticipated future missions. It will also address some of the programmatic developments currently underway at NASA, especially with respect to the NASA Technology Development Program. The effects of the recently enacted FY 17 NASA budget, which includes a sizeable increase, will also be addressed. While funding for basic technology development is still tight, significant efforts are being made in direct support of flight programs. Thermal technology Implementation on current flight programs will be reviewed, and the recent push for CubeSat mission development will also be addressed. Many of these technologies also have broad applicability to DOD (Dept. of Defense), DOE (Dept. of the Environment), and commercial programs. Partnerships have been developed with the Air Force, Navy, and various universities to promote technology development. In addition, technology development activities supported by internal research and development (IRAD) program and the Small Business Innovative Research (SBIR) program are reviewed in this presentation. Specific technologies addressed include; two-phase systems applications and issues on NASA missions, latest developments of electro-hydrodynamically pumped systems, Atomic Layer Deposition (ALD), Micro-scale Heat Transfer, and various other research activities.
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Advanced Methodologies for NASA Science Missions
Hurlburt, N. E.; Feigelson, E.; Mentzel, C.
2017-12-01
Most of NASA's commitment to computational space science involves the organization and processing of Big Data from space-based satellites, and the calculations of advanced physical models based on these datasets. But considerable thought is also needed on what computations are needed. The science questions addressed by space data are so diverse and complex that traditional analysis procedures are often inadequate. The knowledge and skills of the statistician, applied mathematician, and algorithmic computer scientist must be incorporated into programs that currently emphasize engineering and physical science. NASA's culture and administrative mechanisms take full cognizance that major advances in space science are driven by improvements in instrumentation. But it is less well recognized that new instruments and science questions give rise to new challenges in the treatment of satellite data after it is telemetered to the ground. These issues might be divided into two stages: data reduction through software pipelines developed within NASA mission centers; and science analysis that is performed by hundreds of space scientists dispersed through NASA, U.S. universities, and abroad. Both stages benefit from the latest statistical and computational methods; in some cases, the science result is completely inaccessible using traditional procedures. This paper will review the current state of NASA and present example applications using modern methodologies.
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77 FR 6824 - NASA Advisory Council; Science Committee; Meeting
2012-02-09
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-010] NASA Advisory Council; Science... Aeronautics and Space Administration (NASA) announces a meeting of the Science Committee of the NASA Advisory....m. to 2 p.m., Local Time. ADDRESSES: NASA Headquarters, 300 E Street SW., Room 3H46 and 7H45...
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78 FR 64442 - NASA FAR Supplement: Proposal Adequacy Checklist
2013-10-29
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 48 CFR Parts 1815 and 1852 RIN 2700-AE13 NASA FAR...: Proposed rule. SUMMARY: NASA is proposing to amend the NASA FAR Supplement (NFS) to incorporate a proposal... or pricing data. DATES: Interested parties should submit comments to NASA at the address below on or...
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76 FR 59446 - NASA Advisory Council; Science Committee; Meeting
2011-09-26
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice11-084] NASA Advisory Council; Science... Aeronautics and Space Administration (NASA) announces a meeting of the Science Committee of the NASA Advisory..., 2011, 8:30 a.m. to 2 p.m., Local Time. ADDRESSES: NASA Headquarters, 300 E Street, SW., Room 3H46...
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75 FR 35091 - NASA Advisory Council; Science Committee; Meeting
2010-06-21
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-068)] NASA Advisory Council; Science... Aeronautics and Space Administration (NASA) announces a meeting of the Science Committee of the NASA Advisory....m. to 1:30 p.m., e.d.t. ADDRESSES: NASA Headquarters, 300 E Street, SW., Room 3H46, Washington, DC...
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76 FR 67482 - NASA Advisory Council; Charter Renewal
2011-11-01
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (11-108)] NASA Advisory Council; Charter Renewal AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of renewal and amendment of the charter of the NASA Advisory Council. SUMMARY: Pursuant to sections 14(b)(1) and 9(c) of...
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78 FR 66964 - NASA Advisory Council; Charter Renewal
2013-11-07
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (13-130)] NASA Advisory Council; Charter Renewal AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of renewal and amendment of the charter of the NASA Advisory Council. SUMMARY: Pursuant to sections 14(b)(1) and 9(c) of...
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75 FR 52375 - NASA Advisory Council; Exploration Committee
2010-08-25
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (10-094)] NASA Advisory Council... National Aeronautics and Space Administration announces a meeting of the Exploration Committee of the NASA Advisory Council. DATES: Tuesday, September 21, 2010, 1 p.m.-6:30 p.m., Local Time. ADDRESSES: NASA...
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75 FR 4875 - NASA Commercial Space Committee; Meeting
2010-01-29
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (10-014)] NASA Commercial Space Committee... and Space Administration announces a meeting of the Commercial Space Committee to the NASA Advisory Council. DATES: Tuesday, February 16, 2010, 10 a.m.-5 p.m., Eastern. ADDRESSES: NASA Headquarters, 300 E...
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Greene, Benjamin; McClure, Mark B.
2012-01-01
The NASA Johnson Space Center White Sands Test Facility (WSTF) has performed testing of hazardous and reactive aerospace fluids, including hypergolic propellants, with materials since the 1960s with the Apollo program. Amongst other test activities, Test 15 is a NASA standard test for evaluating the reactivity of materials with selected aerospace fluids, in particular hydrazine, monomethylhydrazine, uns-dimethylhydrazine, Aerozine 50, dinitrogen tetroxide oxidizers, and ammonia. This manuscript provides an overview of the history of Test 15 over a timeline ranging from prior to its development and first implementation as a NASA standard test in 1974 to its current refinement. Precursor documents to NASA standard tests, as they are currently known, are reviewed. A related supplementary test, international standardization, and enhancements to Test 15 are also discussed. Because WSTF was instrumental in the development and implementation of Test 15, WSTF experience and practices are referred to in this manuscript.
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Zhang, Kai; Guo, Yawei; Ge, Zhenzhen; Zhang, Zhihui; Da, Yurong; Li, Wen; Zhang, Zimu; Xue, Zhenyi; Li, Yan; Ren, Yinghui; Jia, Long; Chan, Koon-Ho; Yang, Fengrui; Yan, Jun; Yao, Zhi; Xu, Aimin; Zhang, Rongxin
2017-09-01
T helper 17 (Th17) cells are vital components of the adaptive immune system involved in the pathogenesis of most autoimmune and inflammatory syndromes, and adiponectin(ADN) is correlated with inflammatory diseases such as multiple sclerosis (MS) and type II diabetes. However, the regulatory effects of adiponectin on pathogenic Th17 cell and Th17-mediated autoimmune central nervous system (CNS) inflammation are not fully understood. In this study, we demonstrated that ADN could inhibit Th1 and Th17 but not Th2 cells differentiation in vitro. In the in vivo study, we demonstrated that ADN deficiency promoted CNS inflammation and demyelination and exacerbated experimental autoimmune encephalomyelitis (EAE), an animal model of human MS. Furthermore, ADN deficiency increased the Th1 and Th17 cell cytokines of both the peripheral immune system and CNS in mice suffering from EAE. It is worth mentioning that ADN deficiency predominantly promoted the antigen-specific Th17 cells response in autoimmune encephalomyelitis. In addition, in vitro and in vivo, ADN upregulated sirtuin 1 (SIRT1) and peroxisome proliferator-activated receptor γ (PPARγ) and inhibited retinoid-related orphan receptor-γt (RORγt); the key transcription factor during Th17 cell differentiation. These results systematically uncovered the role and mechanism of adiponectin on pathogenic Th17 cells and suggested that adiponectin could inhibit Th17 cell-mediated autoimmune CNS inflammation.
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Wang, Zheng; He, Shengbing; Huang, Jungchen; Zhou, Weili; Chen, Wanning
2018-03-29
Phosphorus (P) limitation has been demonstrated for micro-polluted surface water denitrification treatment in previous study. In this paper, a lab-scale comparative study of autotrophic denitrification (ADN) and heterotrophic denitrification (HDN) in phosphorus-limited surface water was investigated, aiming to find out the optimal nitrogen/phosphorus (N/P) ratio and the mechanism of the effect of P limitation on ADN and HDN. Furthermore, the optimal denitrification process was applied to the West Lake denitrification project, aiming to improve the water quality of the West Lake from worse than grade V to grade IV (GB3838-2006). The lab-scale study showed that the lack of P indeed inhibited HDN more greatly than ADN. The optimal N/P ratio for ADN and HDN was 25 and a 0.15 mg PO 4 3- -P L -1 of microbial available phosphorus (MAP) was observed. P additions could greatly enhance the resistance of ADN and HDN to hydraulic loading shock. Besides, The P addition could effectively stimulate the HDN performance via enriching the heterotrophic denitrifiers and the denitrifying phosphate-accumulating organisms (DNPAOs). Additionally, HDN was more effective and cost-effective than ADN for treating P-limited surface water. The study of the full-scale HDBF (heterotrophic denitrification biofilter) indicated that the denitrification performance was periodically impacted by P limitation, particularly at low water temperatures. Copyright © 2018 Elsevier Ltd. All rights reserved.
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Unique Education and Workforce Development for NASA Engineers
Forsgren, Roger C.; Miller, Lauren L.
2010-01-01
NASA engineers are some of the world's best-educated graduates, responsible for technically complex, highly significant scientific programs. Even though these professionals are highly proficient in traditional analytical competencies, there is a unique opportunity to offer continuing education that further enhances their overall scientific minds. With a goal of maintaining the Agency's passionate, "best in class" engineering workforce, the NASA Academy of Program/Project & Engineering Leadership (APPEL) provides educational resources encouraging foundational learning, professional development, and knowledge sharing. NASA APPEL is currently partnering with the scientific community's most respected subject matter experts to expand its engineering curriculum beyond the analytics and specialized subsystems in the areas of: understanding NASA's overall vision and its fundamental basis, and the Agency initiatives supporting them; sharing NASA's vast reservoir of engineering experience, wisdom, and lessons learned; and innovatively designing hardware for manufacturability, assembly, and servicing. It takes collaboration and innovation to educate an organization that possesses such a rich and important historyand a future that is of great global interest. NASA APPEL strives to intellectually nurture the Agency's technical professionals, build its capacity for future performance, and exemplify its core valuesalJ to better enable NASA to meet its strategic visionand beyond.
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FAA/NASA UAS Traffic Management Pilot Program (UPP)
Johnson, Ronald D.; Kopardekar, Parimal H.; Rios, Joseph L.
2018-01-01
NASA Ames is leading ATM R&D organization. NASA started working on UTM in 2012, it's come a long way primarily due to close relationship with FAA and industry. We have a research transition team between FAA and NASA for UTM. We have a few other RTTs as well. UTM is a great example of collaborative innovation, and now it's reaching very exciting stage of UTM Pilot Project (UPP). NASA is supporting FAA and industry to make the UPP most productive and successful.
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76 FR 8380 - NASA Advisory Council; Science Committee; Meeting
2011-02-14
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (11-114)] NASA Advisory Council; Science... Aeronautics and Space Administration (NASA) announces a meeting of the Science Committee of the NASA Advisory...:30 a.m. to 2 p.m., Local Time. ADDRESSES: NASA Headquarters, 300 E Street, SW., Rooms 9H40 and 3H46...
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NASA logo painted on orbiter Endeavour
1998-01-01
A KSC worker paints the NASA logo on the port wing of the orbiter Endeavour, which is scheduled to launch in December for STS-88. The paint is a special pigment that takes 18 hours to dry; the whole process takes approximately two weeks to complete. The NASA logo, termed 'meatball,' was originally designed in the late 1950s. It symbolized NASA's role in aeronautics and space in the early years of the agency. The original design included a white border surrounding it. The border was dropped for the Apollo 7 mission in October 1968, replaced with royal blue to match the background of the emblem. In 1972 the logo was replaced by a simple and contemporary design -- the 'worm' -- which was retired from use last year. NASA reverted to its original logo in celebration of the agency's 40th anniversary in October, and the 'golden age' of America's space program. All the orbiters will bear the new logo.
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Aplicaciones de la genética molecular en la practica forense
Directory of Open Access Journals (Sweden)
Oscar F. Ramos M.
1993-10-01
Full Text Available Desde el desarrollo de las huellas digitales a finales del siglo XIX, la tipificación del ADN por VNTR, representa la innovación más poderosa que se haya desarrollado en las ciencias forenses durante el siglo XX. Con el descubrimiento en 1980 del polimorfismo del ADN en el genoma humano y con la subsecuente demostración de que tal hipervariabilidad esta ampliamente distribuida en los humanos, las ciencias forenses han reconocido el enorme potencial que ofrece la tipificación del ADN para la identificación de un individuo a partir de una muestra biológica dejada en la escena del crimen. La utilidad de la tipificación del ADN como herramienta forense recae no solo en su alto poder de discriminación entre los individuos de una población, sino también porque se pueden utilizar muchos materiales de origen biológico, en diferentes circunstancias, que de otra manera serian inútiles en las pruebas de tipificación tradicional. El debate actual sobre las pruebas de ADN pone de relieve la necesidad de imponer un mayor rigor ante las dificultades que aparecen cuando una tecnología científica bastante compleja se introduce como prueba ante un tribunal de justicia. Se discuten las ventajas y limitaciones sobre el uso del polimorfismo del ADN en la medicina forense. En Colombia se deben establecer criterios nacionales para que las pruebas forenses del ADN sirvan a los intereses de la justicia, bien sea para identificar a un criminal o para absolver a un inocente.
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Public Access to NASA's Earth Science Data
Behnke, J.; James, N.
2013-12-01
Many steps have been taken over the past 20 years to make NASA's Earth Science data more accessible to the public. The data collected by NASA represent a significant public investment in research. NASA holds these data in a public trust to promote comprehensive, long-term Earth science research. Consequently, NASA developed a free, open and non-discriminatory policy consistent with existing international policies to maximize access to data and to keep user costs as low as possible. These policies apply to all data archived, maintained, distributed or produced by NASA data systems. The Earth Observing System Data and Information System (EOSDIS) is a major core capability within NASA Earth Science Data System Program. EOSDIS is designed to ingest, process, archive, and distribute data from approximately 90 instruments. Today over 6800 data products are available to the public through the EOSDIS. Last year, EOSDIS distributed over 636 million science data products to the user community, serving over 1.5 million distinct users. The system supports a variety of science disciplines including polar processes, land cover change, radiation budget, and most especially global climate change. A core philosophy of EOSDIS is that the general user is best served by providing discipline specific support for the data. To this end, EOSDIS has collocated NASA Earth science data with centers of science discipline expertise, called Distributed Active Archive Centers (DAACs). DAACs are responsible for data management, archive and distribution of data products. There are currently twelve DAACs in the EOSDIS system. The centralized entrance point to the NASA Earth Science data collection can be found at http://earthdata.nasa.gov. Over the years, we have developed several methods for determining needs of the user community including use of the American Customer Satisfaction Index survey and a broad metrics program. Annually, we work with an independent organization (CFI Group) to send this
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2012-01-01
Success in executing future NASA space missions will depend on advanced technology developments that should already be underway. It has been years since NASA has had a vigorous, broad-based program in advanced space technology development, and NASA's technology base is largely depleted. As noted in a recent National Research Council report on the U.S. civil space program: Future U.S. leadership in space requires a foundation of sustained technology advances that can enable the development of more capable, reliable, and lower-cost spacecraft and launch vehicles to achieve space program goals. A strong advanced technology development foundation is needed also to enhance technology readiness of new missions, mitigate their technological risks, improve the quality of cost estimates, and thereby contribute to better overall mission cost management. Yet financial support for this technology base has eroded over the years. The United States is now living on the innovation funded in the past and has an obligation to replenish this foundational element. NASA has developed a draft set of technology roadmaps to guide the development of space technologies under the leadership of the NASA Office of the Chief Technologist. The NRC appointed the Steering Committee for NASA Technology Roadmaps and six panels to evaluate the draft roadmaps, recommend improvements, and prioritize the technologies within each and among all of the technology areas as NASA finalizes the roadmaps. The steering committee is encouraged by the initiative NASA has taken through the Office of the Chief Technologist (OCT) to develop technology roadmaps and to seek input from the aerospace technical community with this study.
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NASA research in aeropropulsion
Energy Technology Data Exchange (ETDEWEB)
Stewart, W.L.; Weber, R.J.
1981-12-01
Future advances in aircraft propulsion systems will be aided by the research performed by NASA and its contractors. This paper gives selected examples of recent accomplishments and current activities relevant to the principal classes of civil and military aircraft. Some instances of new emerging technologies with potential high impact on further progress are discussed. NASA research described includes noise abatement and fuel economy measures for commercial subsonic, supersonic, commuter, and general aviation aircraft, aircraft engines of the jet, turboprop, diesel and rotary types, VTOL, X-wing rotocraft, helicopters, and ''stealth'' aircraft. Applications to military aircraft are also discussed.
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K-12 Project Management Education: NASA Hunch Projects
Morgan, Joe; Zhan, Wei; Leonard, Matt
2013-01-01
To increase the interest in science, technology, engineering, and math (STEM) among high school students, the National Aeronautics and Space Administration (NASA) created the "High Schools United with NASA to Create Hardware" (HUNCH) program. To enhance the experience of the students, NASA sponsored two additional projects that require…
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NASA/Air Force Cost Model: NAFCOM
Winn, Sharon D.; Hamcher, John W. (Technical Monitor)
2002-01-01
The NASA/Air Force Cost Model (NAFCOM) is a parametric estimating tool for space hardware. It is based on historical NASA and Air Force space projects and is primarily used in the very early phases of a development project. NAFCOM can be used at the subsystem or component levels.
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... person's age, general health, pre-existing neurological conditions, adn time between rupture and medical attention. Early diagnosis ... person's age, general health, pre-existing neurological conditions, adn time between rupture and medical attention. Early diagnosis ...
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NASA Education Recommendation Report. Education Design Team 2011
National Aeronautics and Space Administration (NASA), 2011
2011-01-01
The people at National Aeronautics and Space Administration (NASA) are passionate about their work. NASA's missions are exciting to learners of all ages. Since its creation in 1958, NASA's people have been passionate about sharing their inspiring discoveries, research and exploration with students and educators. When retired Marine Corps General…
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NASA Technology Applications Team: Commercial applications of aerospace technology
1994-01-01
The Research Triangle Institute (RTI) Team has maintained its focus on helping NASA establish partnerships with U.S. industry for dual use development and technology commercialization. Our emphasis has been on outcomes, such as licenses, industry partnerships and commercialization of technologies, that are important to NASA in its mission of contributing to the improved competitive position of U.S. industry. The RTI Team has been successful in the development of NASA/industry partnerships and commercialization of NASA technologies. RTI ongoing commitment to quality and customer responsiveness has driven our staff to continuously improve our technology transfer methodologies to meet NASA's requirements. For example, RTI has emphasized the following areas: (1) Methodology For Technology Assessment and Marketing: RTI has developed and implemented effective processes for assessing the commercial potential of NASA technologies. These processes resulted from an RTI study of best practices, hands-on experience, and extensive interaction with the NASA Field Centers to adapt to their specific needs. (2) Effective Marketing Strategies: RTI surveyed industry technology managers to determine effective marketing tools and strategies. The Technology Opportunity Announcement format and content were developed as a result of this industry input. For technologies with a dynamic visual impact, RTI has developed a stand-alone demonstration diskette that was successful in developing industry interest in licensing the technology. And (3) Responsiveness to NASA Requirements: RTI listened to our customer (NASA) and designed our processes to conform with the internal procedures and resources at each NASA Field Center and the direction provided by NASA's Agenda for Change. This report covers the activities of the Research Triangle Institute Technology Applications Team for the period 1 October 1993 through 31 December 1994.
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1992-08-01
entrepreneurship courses for laid-off McDonnell Douglas employees. Over 500 have participated in the classes. • McDonnell Douglas donated its lease-hold...international programs and organizations • Analysis of regional financing programs The St. Louis World Trade Center franchise was acquired for the region...averaged over the 1970’s, the defense cutbacks are likely contribute only a small part of that objective. 2 38 7 Figure 5.3 REAL GDP BASE VS
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Targeting Prostate Cancer with Bifunctional Modulators of the Androgen Receptor
2015-06-01
Wittmann, B.; Dwyer, M.; Cui, H.; Dye, D.; McDonnell, D.; Norris , J. Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists...Wittmann, B.; Dwyer, M.; Cui, H.; Dye, D.; McDonnell, D.; Norris , J. Inhibition of prostate cancer cell growth by second-site androgen receptor...important clin- ical problem in diseases such as asthma (51, 52), ne- phrotic syndrome (53), and malignancies such as acute lymphoblastic leukemia (54
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76 FR 41825 - NASA Advisory Council; Meeting
2011-07-15
... Avenue, NASA Research Park, NASA Ames Research Center (ARC), Moffett Field, CA 94035-1000. FOR FURTHER... Headquarters, Washington, DC 20546, 202/358-1148. SUPPLEMENTARY INFORMATION: The agenda for the meeting will...
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Pharmacy in Space: A Session on NASA Technologies
Richmond, Robert C.
1998-01-01
In 1993, Vice-president Gore was charged with creation of a correctional plan for the poor findings from an efficiency study of governmental agencies. That correctional analysis was then used to support efforts to balance the budget in ways anticipated to improve the value returned per tax payer dollar spent. The final result was a broad initiative collectively termed "reinventing the government", which included major restructuring within NASA as well, termed "reinventing NASA This included substantial elimination of middle management and downsizing such that about 2 million government workers employed in 1992 has shrunk now to about 1.2 million government workers who are employed in ways that at least somewhat decrease bureaucratic and programmatic inefficiencies. Today, "reinvented NASA" has an awareness of contractual commitment to the public. NASA now operates within a so-called "strategic plan" that requires awareness and response to domestic needs. This is important to this audience because it means that NASA is committed to exploring interactions that you may wish to initiate. That is, you are urged to explore with NASA on topics of educational support, collaborative research, or commercial partnerships in drug development and application, as the pertinent examples here, in ways that can include involvement of central NASA resources and missions.
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National Aeronautics and Space Administration — MY NASA DATA (MND) is a tool that allows anyone to make use of satellite data that was previously unavailable.Through the use of MND’s Live Access Server (LAS) a...
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Status of NASA's commercial cargo and crew transportation initiative
Lindenmoyer, Alan; Stone, Dennis
2010-03-01
To stimulate the commercial space transportation industry, the National Aeronautics and Space Administration (NASA) is facilitating the demonstration of Commercial Orbital Transportation Services (COTS) to Low Earth Orbit (LEO) by private-sector companies. In 2006, NASA entered into funded agreements with two such companies to share NASA's 500 million investment, Space Exploration Technologies (SpaceX) and Rocketplane Kistler (RpK), each of which proposed to obtain the additional private financing needed to complete its flight demonstrations. In 2007, NASA terminated the agreement with RpK because it failed to meet a series of technical and financial milestones which were necessary to receive the incremental NASA payments. In 2008, NASA conducted another competition for the remaining 170 million of NASA funding and entered into a funded agreement with Orbital Sciences Corporation (OSC). This paper provides an overview of the COTS approach of SpaceX and OSC and the status of their efforts to develop reliable and cost-effective commercial transportation to serve the LEO marketplace.
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48 CFR 1852.233-70 - Protests to NASA.
2010-10-01
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Protests to NASA. 1852.233... 1852.233-70 Protests to NASA. As prescribed in 1833.106-70, insert the following provision: Protests to NASA (OCT 2002) Potential bidders or offerors may submit a protest under 48 CFR part 33 (FAR part 33...
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Hong, Seok Kwan; Gul, Yunus A; Ithnin, Hairuszah; Talib, Arni; Seow, Heng Fong
2004-01-01
Promising new pharmacological agents and gene therapy targeting cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) could modulate treatment of colorectal cancer in the future. The aim of this study was to elucidate the expression fo beta-catenin and teh presence of COX-2 and iNOS in colorectal cancer specimens in Malaysia. This is a useful prelude to future studies investigating interventions directed towards COX-2 adn iNOS. A cross-section study using retrospective data over a 2-year period (1999-2000) involved 101 archival, formalin-fixed, paraffin-embedded tissue samples of colorectal cancers that were surgically resected in a tertiary referral. COX-2 production was detected in adjacent normal tissue in 34 sample (33.7%) and in tumour tissue in 60 samples (59.4%). More tumours expressed iNOS (82/101, 81.2%) than COX-2. No iNOS expression was detected in adjacent normal tissue. Intense beta-catenin immunoreactivity at the cell-to-cell border. Poorly differentiated tumours had significantly lower total beta-catenin (p = 0.009) and COX-2 scores (p = 0.031). No significant relationships were established between pathological stage and beta-catenin, COX-2 and iNOS scores. the accumulation of beta-catenin does not seem to be sufficient to activate pathways that lead to increased COX-2 and iNOS expression. A high proportion of colorectal cancers were found to express COX-2 and a significant number produced iNOS, suggesting that their inhibitors may be potentially useful as chemotherapeutic agents in the management of colorectal cancer.
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Study of aging mechanism of ammonium dinitramide using thermal analysis and spectrometry
Matsunaga, Hiroki; Yoshino, Satoru; Kumasaki, Mieko; Miyake, Atsumi; Habu, Hiroto; 松永, 浩貴; 吉野, 悟; 熊崎, 美枝子; 三宅, 淳巳; 羽生, 宏人
2011-01-01
To get better information about aging mechanism of ammonium dinitramide (ADN) during storage, thermal analysis and spectrometry were carried out. The infrared, Raman, ultraviolet spectrometry and the sealed cell differential scanning calorimetry (SC-DSC) of AND (1998) which has been stored for 11 years in a dark place suggested that ADN has degraded to ammonium nitrate (AN) during the storage. The amount of ADN in AND (1998) was determined to be 57 wt.％ at the surface region and 89 wt.％ at th...
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The NASA Astrobiology Roadmap.
Des Marais, David J; Nuth, Joseph A; Allamandola, Louis J; Boss, Alan P; Farmer, Jack D; Hoehler, Tori M; Jakosky, Bruce M; Meadows, Victoria S; Pohorille, Andrew; Runnegar, Bruce; Spormann, Alfred M
2008-08-01
The NASA Astrobiology Roadmap provides guidance for research and technology development across the NASA enterprises that encompass the space, Earth, and biological sciences. The ongoing development of astrobiology roadmaps embodies the contributions of diverse scientists and technologists from government, universities, and private institutions. The Roadmap addresses three basic questions: how does life begin and evolve, does life exist elsewhere in the universe, and what is the future of life on Earth and beyond? Seven Science Goals outline the following key domains of investigation: understanding the nature and distribution of habitable environments in the universe, exploring for habitable environments and life in our own Solar System, understanding the emergence of life, determining how early life on Earth interacted and evolved with its changing environment, understanding the evolutionary mechanisms and environmental limits of life, determining the principles that will shape life in the future, and recognizing signatures of life on other worlds and on early Earth. For each of these goals, Science Objectives outline more specific high priority efforts for the next three to five years. These eighteen objectives are being integrated with NASA strategic planning.
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NASA's "Eyes" Focus on Education
Hussey, K.
2016-12-01
NASA's "Eyes on…" suite of products continues to grow in capability and popularity. The "Eyes on the Earth", "Eyes on the Solar System" and "Eyes on Exoplanets" real-time, 3D interactive visualization products have proven themselves as highly effective demonstration and communication tools for NASA's Earth and Space Science missions. This presentation will give a quick look at the latest updates to the "Eyes" suite plus what is being done to make them tools for STEM Education.
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Challenges of Information Technology Security in the NASA Environment
Santiago, S. S.
2000-01-01
A brief description of the NASA organization and how the CIO responsibilities are integrated into that organization followed by an introduction of the NASA ITS Program goals and objectives. An overview of the four major enterprises' cultures and how those cultures tie back to the Enterprises' missions. A description of the ITS challenges that exist stemming from the competing NASA Enterprises' requirements and how they have formed the basis of the NASA ITS Program. A talk will focus on policies and procedures and the technology being incorporated into the NASA infrastructure and how that technology ties back to the policies and procedures.
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The NASA Carbon Monitoring System
Hurtt, G. C.
2015-12-01
Greenhouse gas emission inventories, forest carbon sequestration programs (e.g., Reducing Emissions from Deforestation and Forest Degradation (REDD and REDD+), cap-and-trade systems, self-reporting programs, and their associated monitoring, reporting and verification (MRV) frameworks depend upon data that are accurate, systematic, practical, and transparent. A sustained, observationally-driven carbon monitoring system using remote sensing data has the potential to significantly improve the relevant carbon cycle information base for the U.S. and world. Initiated in 2010, NASA's Carbon Monitoring System (CMS) project is prototyping and conducting pilot studies to evaluate technological approaches and methodologies to meet carbon monitoring and reporting requirements for multiple users and over multiple scales of interest. NASA's approach emphasizes exploitation of the satellite remote sensing resources, computational capabilities, scientific knowledge, airborne science capabilities, and end-to-end system expertise that are major strengths of the NASA Earth Science program. Through user engagement activities, the NASA CMS project is taking specific actions to be responsive to the needs of stakeholders working to improve carbon MRV frameworks. The first phase of NASA CMS projects focused on developing products for U.S. biomass/carbon stocks and global carbon fluxes, and on scoping studies to identify stakeholders and explore other potential carbon products. The second phase built upon these initial efforts, with a large expansion in prototyping activities across a diversity of systems, scales, and regions, including research focused on prototype MRV systems and utilization of COTS technologies. Priorities for the future include: 1) utilizing future satellite sensors, 2) prototyping with commercial off-the-shelf technology, 3) expanding the range of prototyping activities, 4) rigorous evaluation, uncertainty quantification, and error characterization, 5) stakeholder
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Evolving Metadata in NASA Earth Science Data Systems
Mitchell, A.; Cechini, M. F.; Walter, J.
2011-12-01
NASA's Earth Observing System (EOS) is a coordinated series of satellites for long term global observations. NASA's Earth Observing System Data and Information System (EOSDIS) is a petabyte-scale archive of environmental data that supports global climate change research by providing end-to-end services from EOS instrument data collection to science data processing to full access to EOS and other earth science data. On a daily basis, the EOSDIS ingests, processes, archives and distributes over 3 terabytes of data from NASA's Earth Science missions representing over 3500 data products ranging from various types of science disciplines. EOSDIS is currently comprised of 12 discipline specific data centers that are collocated with centers of science discipline expertise. Metadata is used in all aspects of NASA's Earth Science data lifecycle from the initial measurement gathering to the accessing of data products. Missions use metadata in their science data products when describing information such as the instrument/sensor, operational plan, and geographically region. Acting as the curator of the data products, data centers employ metadata for preservation, access and manipulation of data. EOSDIS provides a centralized metadata repository called the Earth Observing System (EOS) ClearingHouse (ECHO) for data discovery and access via a service-oriented-architecture (SOA) between data centers and science data users. ECHO receives inventory metadata from data centers who generate metadata files that complies with the ECHO Metadata Model. NASA's Earth Science Data and Information System (ESDIS) Project established a Tiger Team to study and make recommendations regarding the adoption of the international metadata standard ISO 19115 in EOSDIS. The result was a technical report recommending an evolution of NASA data systems towards a consistent application of ISO 19115 and related standards including the creation of a NASA-specific convention for core ISO 19115 elements. Part of
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DOE and NASA joint Dark Energy mission
2003-01-01
"DOE and NASA announced their plan for a Joint Dark Energy Mission (JDEM) on October 23, 2003, at the NASA Office of Space Science Structure and Evolution of the Universe Subcommittee (SEUS) meeting" (1 paragraph).
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NASA Year 2000 (Y2K) Program Plan
1998-01-01
NASA initiated the Year 2000 (Y2K) program in August 1996 to address the challenges imposed on Agency software, hardware, and firmware systems by the new millennium. The Agency program is centrally managed by the NASA Chief Information Officer, with decentralized execution of program requirements at each of the nine NASA Centers, Headquarters and the Jet Propulsion Laboratory. The purpose of this Program Plan is to establish Program objectives and performance goals; identify Program requirements; describe the management structure; and detail Program resources, schedules, and controls. Project plans are established for each NASA Center, Headquarters, and the Jet Propulsion Laboratory.
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NASA-427: A New Aluminum Alloy
Nabors, Sammy A.
2015-01-01
NASA's Marshall Space Flight Center researchers have developed a new, stronger aluminum alloy, ideal for cast aluminum products that have powder or paint-baked thermal coatings. With advanced mechanical properties, the NASA-427 alloy shows greater tensile strength and increased ductility, providing substantial improvement in impact toughness. In addition, this alloy improves the thermal coating process by decreasing the time required for heat treatment. With improvements in both strength and processing time, use of the alloy provides reduced materials and production costs, lower product weight, and better product performance. The superior properties of NASA-427 can benefit many industries, including automotive, where it is particularly well-suited for use in aluminum wheels.
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NASA preferred reliability-practices for design and test
Lisk, Ronald C.
1992-01-01
NASA HQ established the NASA R&M Steering Committee (R&MSC) comprised of membership from each NASA field center. The primary charter of the R&MSC is to obtain, record, and share the best design practices that NASA has applied to successful space flight programs and current design considerations (guidelines) that should enhance flight reliability on emerging programs. The practices and guidelines are being assembled in a living document for distribution to NASA centers and the aerospace community. The document will be updated annually with additional practices and guidelines as contributions from the centers are reviewed and approved by the R&MSC. Practices and guidelines are not requirements, but rather a means of sharing procedures and techniques that a given center and the R&MSC together feel have strong technical merit and application to the design of space-related equipment.
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NASA Science Served Family Style
Noel-Storr, Jacob; Mitchell, S.; Drobnes, E.
2010-01-01
Family oriented innovative programs extend the reach of many traditional out-of-school venues to involve the entire family in learning in comfortable and fun environments. Research shows that parental involvement is key to increasing student achievement outcomes, and family-oriented programs have a direct impact on student performance. Because families have the greatest influence on children's attitudes towards education and career choices, we have developed a Family Science program that provides families a venue where they can explore the importance of science and technology in our daily lives by engaging in learning activities that change their perception and understanding of science. NASA Family Science Night strives to change the way that students and their families participate in science, within the program and beyond. After three years of pilot implementation and assessment, our evaluation data shows that Family Science Night participants have positive change in their attitudes and involvement in science. Even after a single session, families are more likely to engage in external science-related activities and are increasingly excited about science in their everyday lives. As we enter our dissemination phase, NASA Family Science Night will be compiling and releasing initial evaluation results, and providing facilitator training and online support resources. Support for NASA Family Science Nights is provided in part through NASA ROSES grant NNH06ZDA001N.
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48 CFR 1852.242-73 - NASA contractor financial management reporting.
2010-10-01
... Provisions and Clauses 1852.242-73 NASA contractor financial management reporting. As prescribed in 1842.7202, insert the following clause: NASA Contractor Financial Management Reporting (NOV 2004) (a) The Contractor... instructions in NASA Procedures and Guidelines (NPR) 9501.2, NASA Contractor Financial Management Reporting...
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75 FR 17437 - NASA Advisory Council; Commercial Space Committee; Meeting
2010-04-06
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (10-039)] NASA Advisory Council; Commercial... Committee of the NASA Advisory Council. DATES: Monday, April 26, 2010, 1:30 p.m.-6 p.m. CDT. ADDRESSES: NASA Johnson Space Center, Gilruth Conference Center, 2101 NASA Parkway, Houston, TX 77058. FOR FURTHER...
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77 FR 52067 - NASA Advisory Council; Commercial Space Committee; Meeting
2012-08-28
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [12-069] NASA Advisory Council; Commercial Space.... DATES: Tuesday, September 18, 2012, 11:45 a.m.-5:30 p.m.; Local Time. ADDRESSES: NASA Ames Research Center (ARC), The Showroom, Building M-3, NASA Ames Conference Center, 500 Severyns Road, NASA Research...
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NASA Space Biology Plant Research for 2010-2020
Levine, H. G.; Tomko, D. L.; Porterfield, D. M.
2012-01-01
The U.S. National Research Council (NRC) recently published "Recapturing a Future for Space Exploration: Life and Physical Sciences Research for a New Era" (http://www.nap.edu/catalog.php?record id=13048), and NASA completed a Space Biology Science Plan to develop a strategy for implementing its recommendations ( http://www.nasa.gov/exploration/library/esmd documents.html). The most important recommendations of the NRC report on plant biology in space were that NASA should: (1) investigate the roles of microbial-plant systems in long-term bioregenerative life support systems, and (2) establish a robust spaceflight program of research analyzing plant growth and physiological responses to the multiple stimuli encountered in spaceflight environments. These efforts should take advantage of recently emerged analytical technologies (genomics, transcriptomics, proteomics, metabolomics) and apply modern cellular and molecular approaches in the development of a vigorous flight-based and ground-based research program. This talk will describe NASA's strategy and plans for implementing these NRC Plant Space Biology recommendations. New research capabilities for Plant Biology, optimized by providing state-of-the-art automated technology and analytical techniques to maximize scientific return, will be described. Flight experiments will use the most appropriate platform to achieve science results (e.g., ISS, free flyers, sub-orbital flights) and NASA will work closely with its international partners and other U.S. agencies to achieve its objectives. One of NASA's highest priorities in Space Biology is the development research capabilities for use on the International Space Station and other flight platforms for studying multiple generations of large plants. NASA will issue recurring NASA Research Announcements (NRAs) that include a rapid turn-around model to more fully engage the biology community in designing experiments to respond to the NRC recommendations. In doing so, NASA
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NASA Occupant Protection Standards Development
Somers, Jeffrey; Gernhardt, Michael; Lawrence, Charles
2012-01-01
Historically, spacecraft landing systems have been tested with human volunteers, because analytical methods for estimating injury risk were insufficient. These tests were conducted with flight-like suits and seats to verify the safety of the landing systems. Currently, NASA uses the Brinkley Dynamic Response Index to estimate injury risk, although applying it to the NASA environment has drawbacks: (1) Does not indicate severity or anatomical location of injury (2) Unclear if model applies to NASA applications. Because of these limitations, a new validated, analytical approach was desired. Leveraging off of the current state of the art in automotive safety and racing, a new approach was developed. The approach has several aspects: (1) Define the acceptable level of injury risk by injury severity (2) Determine the appropriate human surrogate for testing and modeling (3) Mine existing human injury data to determine appropriate Injury Assessment Reference Values (IARV). (4) Rigorously Validate the IARVs with sub-injurious human testing (5) Use validated IARVs to update standards and vehicle requirement
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NASA-IGES Translator and Viewer
Chou, Jin J.; Logan, Michael A.
1995-01-01
NASA-IGES Translator (NIGEStranslator) is a batch program that translates a general IGES (Initial Graphics Exchange Specification) file to a NASA-IGES-Nurbs-Only (NINO) file. IGES is the most popular geometry exchange standard among Computer Aided Geometric Design (CAD) systems. NINO format is a subset of IGES, implementing the simple and yet the most popular NURBS (Non-Uniform Rational B-Splines) representation. NIGEStranslator converts a complex IGES file to the simpler NINO file to simplify the tasks of CFD grid generation for models in CAD format. The NASA-IGES Viewer (NIGESview) is an Open-Inventor-based, highly interactive viewer/ editor for NINO files. Geometry in the IGES files can be viewed, copied, transformed, deleted, and inquired. Users can use NIGEStranslator to translate IGES files from CAD systems to NINO files. The geometry then can be examined with NIGESview. Extraneous geometries can be interactively removed, and the cleaned model can be written to an IGES file, ready to be used in grid generation.
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78 FR 64253 - NASA Asteroid Initiative Idea Synthesis Workshop
2013-10-28
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: 13-124] NASA Asteroid Initiative Idea.... SUMMARY: The National Aeronautics and Space Administration announces that the agency will resume the NASA... INFORMATION CONTACT: Michele Gates, Senior Technical Advisor, NASA Human Exploration and Operations Mission...
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78 FR 69885 - NASA Advisory Council; Aeronautics Committee; Meeting
2013-11-21
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: 13-133] NASA Advisory Council; Aeronautics... Aeronautics and Space Administration announces a meeting of the Aeronautics Committee of the NASA Advisory... INFORMATION CONTACT: Ms. Susan L. Minor, Executive Secretary for the Aeronautics Committee, NASA Headquarters...
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NASA/FAA North Texas Research Station Overview
Borchers, Paul F.
2012-01-01
NTX Research Staion: NASA research assets embedded in an interesting operational air transport environment. Seven personnel (2 civil servants, 5 contractors). ARTCC, TRACON, Towers, 3 air carrier AOCs(American, Eagle and Southwest), and 2 major airports all within 12 miles. Supports NASA Airspace Systems Program with research products at all levels (fundamental to system level). NTX Laboratory: 5000 sq ft purpose-built, dedicated, air traffic management research facility. Established data links to ARTCC, TRACON, Towers, air carriers, airport and NASA facilities. Re-configurable computer labs, dedicated radio tower, state-of-the-art equipment.
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The Role of Synthetic Biology in NASA's Missions
Rothschild, Lynn J.
2016-01-01
The time has come to for NASA to exploit synthetic biology in pursuit of its missions, including aeronautics, earth science, astrobiology and most notably, human exploration. Conversely, NASA advances the fundamental technology of synthetic biology as no one else can because of its unique expertise in the origin of life and life in extreme environments, including the potential for alternate life forms. This enables unique, creative "game changing" advances. NASA's requirement for minimizing upmass in flight will also drive the field toward miniaturization and automation. These drivers will greatly increase the utility of synthetic biology solutions for military, health in remote areas and commercial purposes. To this end, we have begun a program at NASA to explore the use of synthetic biology in NASA's missions, particular space exploration. As part of this program, we began hosting an iGEM team of undergraduates drawn from Brown and Stanford Universities to conduct synthetic biology research at NASA Ames Research Center. The 2011 team (http://2011.igem.org/Team:Brown-Stanford) produced an award-winning project on using synthetic biology as a basis for a human Mars settlement.
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The 2003 NASA Faculty Fellowship Program Research Reports
Nash-Stevenson, S. K.; Karr, G.; Freeman, L. M.; Bland, J. (Editor)
2004-01-01
For the 39th consecutive year, the NASA Faculty Fellowship Program (NFFP) was conducted at Marshall Space Flight Center. The program was sponsored by NASA Headquarters, Washington, DC, and operated under contract by The University of Alabama in Huntsville. In addition, promotion and applications are managed by the American Society for Engineering Education (ASEE) and assessment is completed by Universities Space Research Association (USRA). The nominal starting and finishing dates for the 10-week program were May 27 through August 1, 2003. The primary objectives of the NASA Faculty Fellowship Program are to: (1) Increase the quality and quantity of research collaborations between NASA and the academic community that contribute to NASA s research objectives; (2) provide research opportunities for college and university faculty that serve to enrich their knowledge base; (3) involve students in cutting-edge science and engineering challenges related to NASA s strategic enterprises, while providing exposure to the methods and practices of real-world research; (4) enhance faculty pedagogy and facilitate interdisciplinary networking; (5) encourage collaborative research and technology transfer with other Government agencies and the private sector; and (6) establish an effective education and outreach activity to foster greater awareness of this program.
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78 FR 54680 - NASA Federal Advisory Committees
2013-09-05
... Committee Management Division, Office of International and Interagency Relations, NASA Headquarters... AGENCY: National Aeronautics and Space Administration. ACTION: Annual Invitation for Public Nominations... invitation for public nominations for service on NASA Federal advisory committees. U.S. citizens may nominate...
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75 FR 11200 - NASA Advisory Council; Commercial Space Committee; Meeting
2010-03-10
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (10-025)] NASA Advisory Council; Commercial... Committee of the NASA Advisory Council. DATES: Tuesday, March 30, 2010, 1 p.m.-5 p.m., EST. ADDRESSES: NASA... Administration, Washington, DC, 20546. Phone 202-358-1686, fax: 202-358-3878, [email protected]nasa.gov...
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75 FR 28821 - NASA Advisory Council; Commercial Space Committee; Meeting
2010-05-24
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-060)] NASA Advisory Council; Commercial... Committee of the NASA Advisory Council. DATES: Thursday, June 17, 2010, 1 p.m.-4 p.m., EDST. ADDRESSES: NASA... Space Administration, Washington, DC 20546. Phone 202- 358-1686, fax: 202-358-3878, [email protected]nasa...
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75 FR 53349 - NASA Advisory Council; Commercial Space Committee; Meeting
2010-08-31
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-098)] NASA Advisory Council; Commercial... Committee of the NASA Advisory Council. DATES: Tuesday September 14, 8 a.m. to 12 noon CDT. ADDRESSES: NASA..., Washington, DC 20546. Phone 202- 358-1686, fax: 202-358-3878, [email protected]nasa.gov . SUPPLEMENTARY...
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78 FR 23199 - NASA FAR Supplement Regulatory Review No. 1
2013-04-18
... 2700-AE01 NASA FAR Supplement Regulatory Review No. 1 AGENCY: National Aeronautics and Space Administration. ACTION: Proposed rule. SUMMARY: NASA is updating the NASA FAR Supplement (NFS) with the goal of... existing regulations. The revisions to this rule are part of NASA's retrospective plan under EO 13563...
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75 FR 59747 - NASA Advisory Council; Meeting.
2010-09-28
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (10-113)] NASA Advisory Council; Meeting. AGENCY: National Aeronautics and Space Administration. ACTION: Notice of meeting. SUMMARY: In accordance... Space Administration announces a meeting of the NASA Advisory Council. DATES: Wednesday, October 6, 2010...
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An Overview of NASA Automotive Component Reliability Studies
Sampson, Michael J.
2016-01-01
The results of NASAs studies into the appropriateness of using US Automotive electronic parts in NASA spaceflight systems will be presented. The first part of the presentation provides an overview of the United States Automotive Electronics Councils AECQ standardization program, the second part provides a summary of the results of NASAs procurement and testing experiences and other lessons learned along with preliminary test results.
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Ulysses - An ESA/NASA cooperative programme
Meeks, W.; Eaton, D.
1990-01-01
Cooperation between ESA and NASA is discussed, noting that the Memorandum of Understanding lays the framework for this relationship, defining the responsibilities of ESA and NASA and providing for appointment of leadership and managers for the project. Members of NASA's Jet Propulsion Laboratory and ESA's ESTEC staff have been appointed to leadership positions within the project and ultimate control of the project rests with the Joint Working Group consisting of two project managers and two project scientists, equally representing both organizations. Coordination of time scales and overall mission design is discussed, including launch cooperation, public relations, and funding of scientific investigations such as Ulysses. Practical difficulties of managing an international project are discussed such as differing documentation requirements and communication techniques, and assurance of equality on projects.
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76 FR 16643 - NASA Advisory Council; Aeronautics Committee; Meeting
2011-03-24
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (11-024)] NASA Advisory Council; Aeronautics... Aeronautics and Space Administration announces a meeting of the Aeronautics Committee of the NASA Advisory.... ADDRESSES: Thursday, April 14, 2011--NASA Dryden Flight Research Center (DFRC), Lilly Drive Building 4825...
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76 FR 58843 - NASA Advisory Council; Aeronautics Committee; Meeting
2011-09-22
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 11-082] NASA Advisory Council; Aeronautics... Aeronautics and Space Administration announces a meeting of the Aeronautics Committee of the NASA Advisory... Headquarters, Washington, DC 20546, (202) 358-0566, or [email protected]nasa.gov . SUPPLEMENTARY INFORMATION: The...
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78 FR 77502 - NASA Applied Sciences Advisory Committee Meeting
2013-12-23
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (13-152)] NASA Applied Sciences Advisory... Aeronautics and Space Administration (NASA) announces a meeting of the Applied Sciences Advisory Committee.... ADDRESSES: NASA Headquarters, Room 3P40, 300 E Street SW., Washington, DC 20546. FOR FURTHER INFORMATION...
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75 FR 41240 - NASA Advisory Council; Aeronautics Committee; Meeting
2010-07-15
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-079)] NASA Advisory Council; Aeronautics... Aeronautics and Space Administration announces a meeting of the Aeronautics Committee of the NASA Advisory....m. to 4 p.m. (local time). ADDRESSES: NASA Glenn Research Center, Building 15, Small Dining...
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75 FR 15743 - NASA Advisory Council; Exploration Committee; Meeting
2010-03-30
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-034)] NASA Advisory Council; Exploration... Aeronautics and Space Administration announces a meeting of the Exploration Committee of the NASA Advisory...-358-1715; [email protected]nasa.gov . SUPPLEMENTARY INFORMATION: The agenda topics for the meeting will...
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78 FR 57178 - NASA Applied Sciences Advisory Committee Meeting
2013-09-17
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-115] NASA Applied Sciences Advisory... Aeronautics and Space Administration (NASA) announces a meeting of the Applied Sciences Advisory Committee.... ADDRESSES: NASA Headquarters, Room 1Q39, 300 E Street SW., Washington, DC 20546. FOR FURTHER INFORMATION...
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NASA FY 2000 Accountability Report
2000-01-01
This Accountability Report consolidates reports required by various statutes and summarizes NASA's program accomplishments and its stewardship over budget and financial resources. It is a culmination of NASA's management process, which begins with mission definition and program planning, continues with the formulation and justification of budgets for the President and Congress, and ends with scientific and engineering program accomplishments. The report covers activities from October 1, 1999, through September 30, 2000. Achievements are highlighted in the Statement of the Administrator and summarized in the Report.
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75 FR 17166 - NASA Advisory Council; Aeronautics Committee; Meeting
2010-04-05
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-038)] NASA Advisory Council; Aeronautics... Aeronautics and Space Administration announces a meeting of the Aeronautics Committee of the NASA Advisory... a.m. to 1 p.m.; Eastern Daylight Time. ADDRESSES: NASA Langley Research Center, Building 1219, Room...
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75 FR 2892 - NASA Advisory Council; Science Committee; Meeting
2010-01-19
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-003)] NASA Advisory Council; Science...: The National Aeronautics and Space Administration (NASA) announces a meeting of the Science Committee of the NASA Advisory Council (NAC). This Committee reports to the NAC. The Meeting will be held for...
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78 FR 10640 - NASA Advisory Council; Aeronautics Committee; Meeting
2013-02-14
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (13-010)] NASA Advisory Council; Aeronautics... Aeronautics and Space Administration announces a meeting of the Aeronautics Committee of the NASA Advisory..., or [email protected]nasa.gov . SUPPLEMENTARY INFORMATION: The meeting will be open to the public up to...
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76 FR 18800 - NASA Advisory Council; Exploration Committee; Meeting.
2011-04-05
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (11-028)] NASA Advisory Council; Exploration... National Aeronautics and Space Administration announces a meeting of the Exploration Committee of the NASA Advisory Council. DATES: Tuesday, April 26, 2011, 1 p.m.-6 p.m., Local Time ADDRESSES: NASA Headquarters...
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75 FR 14472 - NASA Advisory Council; Science Committee; Meeting
2010-03-25
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-033)] NASA Advisory Council; Science...: The National Aeronautics and Space Administration (NASA) announces a meeting of the Science Committee of the NASA Advisory Council (NAC). This Committee reports to the NAC. The Meeting will be held for...
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75 FR 54389 - NASA Advisory Council; Science Committee; Meeting.
2010-09-07
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-103)] NASA Advisory Council; Science... National Aeronautics and Space Administration (NASA) announces a meeting of the Science Committee of the NASA Advisory Council (NAC). This Committee reports to the NAC. The Meeting will be held for the...
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76 FR 183 - NASA Advisory Council; Aeronautics Committee; Meeting
2011-01-03
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (10-172)] NASA Advisory Council... the NASA Advisory Council. The meeting will be held for the purpose of soliciting from the aeronautics... 20546, (202) 358-0566, or [email protected]nasa.gov . SUPPLEMENTARY INFORMATION: The meeting will be open...
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76 FR 40753 - NASA Advisory Council; Aeronautics Committee; Meeting
2011-07-11
..., Building 152, Dailey Road, NASA Research Park, NASA Ames Research Center (ARC), Moffett Field, CA 95035... Committee, National Aeronautics and Space Administration Headquarters, Washington, DC 20546, (202) 358-0566... Christensen, Protocol Specialist, Office of the Center Director, NASA ARC, Moffett Field, CA. For questions...
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2005 NASA Seal/Secondary Air System Workshop, Volume 1
Steinetz, Bruce M. (Editor); Hendricks, Robert C. (Editor)
2006-01-01
The 2005 NASA Seal/Secondary Air System workshop covered the following topics: (i) Overview of NASA s new Exploration Initiative program aimed at exploring the Moon, Mars, and beyond; (ii) Overview of the NASA-sponsored Propulsion 21 Project; (iii) Overview of NASA Glenn s seal project aimed at developing advanced seals for NASA s turbomachinery, space, and reentry vehicle needs; (iv) Reviews of NASA prime contractor, vendor, and university advanced sealing concepts including tip clearance control, test results, experimental facilities, and numerical predictions; and (v) Reviews of material development programs relevant to advanced seals development. Turbine engine studies have shown that reducing high-pressure turbine (HPT) blade tip clearances will reduce fuel burn, lower emissions, retain exhaust gas temperature margin, and increase range. Several organizations presented development efforts aimed at developing faster clearance control systems and associated technology to meet future engine needs. The workshop also covered several programs NASA is funding to develop technologies for the Exploration Initiative and advanced reusable space vehicle technologies. NASA plans on developing an advanced docking and berthing system that would permit any vehicle to dock to any on-orbit station or vehicle. Seal technical challenges (including space environments, temperature variation, and seal-on-seal operation) as well as plans to develop the necessary "androgynous" seal technologies were reviewed. Researchers also reviewed tests completed for the shuttle main landing gear door seals.
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NASA total quality management 1989 accomplishments report
Tai, Betty P. (Editor); Stewart, Lynne M. (Editor)
1990-01-01
NASA and contractor employees achieved many notable improvements in 1989. The highlights of those improvements, described in this seventh annual Accomplishments Report, demonstrate that the people who support NASA's activities are getting more involved in quality and continuous improvement efforts. Their gains solidly support NASA's and this Nation's goal to remain a leader in space exploration and in world-wide market competition, and, when communicated to others through avenues such as this report, foster improvement efforts across government and industry. The principles in practice which led to these process refinements are important cultural elements to any organization's productivity and quality efforts. The categories in this report reflect NASA principles set forth in the 1980's and are more commonly known today as Total Quality Management (TQM): top management leadership and support; strategic planning; focus on the customer; employee training and recognition; employee empowerment and teamwork; measurement and analysis; and quality assurance.
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Directory of Open Access Journals (Sweden)
Ana Teresa Herrera-Reveles
2012-03-01
Full Text Available Con la finalidad de evaluar la asociación de índices de crecimiento en estadios tempranos de peces marinos, se estimó la tasa de crecimiento somático y las condiciones fisiológicas de Eucinostomus argenteus en dos zonas del nor-oriente venezolano: Bahía de Mochima y Golfo de Cariaco. La edad y el crecimiento fueron estimados basados en análisis de otolitos sagitta. Las condiciones fisiológicas fueron evaluadas por medio de las concentraciones de proteínas y la relación ARN/ADN, empleando técnicas espectofotométricas y fluorométricas sobre tejido muscular. Las relaciones entre tallas con la edad y el diámetro de los otolitos resultaron positivas, significativas y ajustadas a un modelo de regresión lineal. Los valores de la tasa de crecimiento reciente oscilaron entre 0.178 y 0.418mm día-1, la tasa de crecimiento retrocalculado varió entre 0.295 y 0.393mm día-1, y la tasa ARN/ADN osciló entre 1.65 y 6.97. No se registraron diferencias entre las zonas de estudio, sin embargo se reportaron diferencias entre localidades. A pesar de no encontrarse correlación entre la tasa de crecimiento y la relación ARN/ADN, los valores reportados sugieren crecimiento positivo de los individuos silvestres en las localidades evaluadas. No obstante, ciertas localidades mostraron valores que indican pobres condiciones nutricionales, pudiendo afectarse a futuro otras tasas vitales.Somatic growth and RNA/DNA rate of Eucinostomus argenteus (Pisces: Gerreidae juveniles stages at two localities of the Venezuelan Caribbean. In order to evaluate the association among growth indices of marine fishes at early life stages, the somatic growth rate and physiological conditions of Eucinostomus argenteus were estimated at two Venezuelan North-East zones: Mochima Bay and Cariaco Gulf. The age and somatic growth rate were estimated based on daily growth increments in sagitta otoliths. The physiological conditions were evaluated with proteins concentrations and RNA
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NASA Earth Science Education Collaborative
Schwerin, T. G.; Callery, S.; Chambers, L. H.; Riebeek Kohl, H.; Taylor, J.; Martin, A. M.; Ferrell, T.
2016-12-01
The NASA Earth Science Education Collaborative (NESEC) is led by the Institute for Global Environmental Strategies with partners at three NASA Earth science Centers: Goddard Space Flight Center, Jet Propulsion Laboratory, and Langley Research Center. This cross-organization team enables the project to draw from the diverse skills, strengths, and expertise of each partner to develop fresh and innovative approaches for building pathways between NASA's Earth-related STEM assets to large, diverse audiences in order to enhance STEM teaching, learning and opportunities for learners throughout their lifetimes. These STEM assets include subject matter experts (scientists, engineers, and education specialists), science and engineering content, and authentic participatory and experiential opportunities. Specific project activities include authentic STEM experiences through NASA Earth science themed field campaigns and citizen science as part of international GLOBE program (for elementary and secondary school audiences) and GLOBE Observer (non-school audiences of all ages); direct connections to learners through innovative collaborations with partners like Odyssey of the Mind, an international creative problem-solving and design competition; and organizing thematic core content and strategically working with external partners and collaborators to adapt and disseminate core content to support the needs of education audiences (e.g., libraries and maker spaces, student research projects, etc.). A scaffolded evaluation is being conducted that 1) assesses processes and implementation, 2) answers formative evaluation questions in order to continuously improve the project; 3) monitors progress and 4) measures outcomes.
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The NASA CSTI High Capacity Power Program
International Nuclear Information System (INIS)
Winter, J.M.
1991-09-01
The SP-100 program was established in 1983 by DOD, DOE, and NASA as a joint program to develop the technology necessary for space nuclear power systems for military and civil applications. During 1986 and 1987, the NASA Advanced Technology Program was responsible for maintaining the momentum of promising technology advancement efforts started during Phase 1 of SP-100 and to strengthen, in key areas, the chances for successful development and growth capability of space nuclear reactor power systems for future space applications. In 1988, the NASA Advanced Technology Program was incorporated into NASA's new Civil Space Technology Initiative (CSTI). The CSTI program was established to provide the foundation for technology development in automation and robotics, information, propulsion, and power. The CSTI High Capacity Power Program builds on the technology efforts of the SP-100 program, incorporates the previous NASA advanced technology project, and provides a bridge to the NASA exploration technology programs. The elements of CSTI high capacity power development include conversion systems: Stirling and thermoelectric, thermal management, power management, system diagnostics, and environmental interactions. Technology advancement in all areas, including materials, is required to provide the growth capability, high reliability, and 7 to 10 year lifetime demanded for future space nuclear power systems. The overall program will develop and demonstrate the technology base required to provide a wide range of modular power systems while minimizing the impact of day/night operations as well as attitudes and distance from the Sun. Significant accomplishments in all of the program elements will be discussed, along with revised goals and project timelines recently developed
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75 FR 80081 - NASA Advisory Council; Exploration Committee; Meeting
2010-12-21
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (10-167)] NASA Advisory Council... the NASA Advisory Council. DATES: Tuesday, January 11, 2011, 10:30 a.m.-5:45 p.m., Local Time ADDRESSES: NASA Headquarters, Glennan Conference Room-1Q39; 300 E Street, SW., Washington, DC 20546 FOR...
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78 FR 5122 - NASA Security and Protective Services Enforcement
2013-01-24
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 14 CFR Parts 1203a, 1203b, and 1204 [Docket No NASA-2012-0007] RIN 2700-AD89 NASA Security and Protective Services Enforcement AGENCY: National Aeronautics... nonsubstantive changes to NASA regulations to clarify the procedures for establishing controlled/ secure areas...
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78 FR 41114 - NASA Advisory Council; Aeronautics Committee; Meeting
2013-07-09
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-075] NASA Advisory Council; Aeronautics... Aeronautics and Space Administration announces a meeting of the Aeronautics Committee of the NASA Advisory... planning. DATES: Tuesday, July 30, 2013, 9:00 a.m. to 5:00 p.m.; Local Time. ADDRESSES: NASA Headquarters...
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77 FR 38091 - NASA Advisory Council; Aeronautics Committee; Meeting.
2012-06-26
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: 12-047] NASA Advisory Council; Aeronautics... National Aeronautics and Space Administration announces a meeting of the Aeronautics Committee of the NASA..., July 24, 2012, 8 a.m. to 3 p.m. local time. ADDRESSES: NASA Goddard Space Flight Center (GSFC...
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75 FR 50782 - NASA Advisory Council; Aeronautics Committee; Meeting
2010-08-17
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-087)] NASA Advisory Council; Aeronautics... Aeronautics and Space Administration announces a meeting of the Aeronautics Committee of the NASA Advisory..., 2010, 8 a.m. to 12:30 p.m.; Local Time. ADDRESSES: NASA Ames Conference Center, Building 3, 500...
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NASA Standards Inform Comfortable Car Seats
2014-01-01
NASA developed standards, which included the neutral body posture (NBP), to specify ways to design flight systems that support human health and safety. Nissan Motor Company, with US offices in Franklin, Tennessee, turned to NASA's NBP research for the development of a new driver's seat. The 2013 Altima now features the new seat, and the company plans to incorporate the seats in upcoming vehicles.
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NASA Technology Readiness Level Definitions
Mcnamara, Karen M.
2012-01-01
This presentation will cover the basic Technology Readiness Level (TRL) definitions used by the National Aeronautics and Space Administration (NASA) and their specific wording. We will discuss how they are used in the NASA Project Life Cycle and their effectiveness in practice. We'll also discuss the recent efforts by the International Standards Organization (ISO) to develop a broadly acceptable set of TRL definitions for the international space community and some of the issues brought to light. This information will provide input for further discussion of the use of the TRL scale in manufacturing.
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NASA program planning on nuclear electric propulsion
International Nuclear Information System (INIS)
Bennett, G.L.; Miller, T.J.
1992-03-01
As part of the focused technology planning for future NASA space science and exploration missions, NASA has initiated a focused technology program to develop the technologies for nuclear electric propulsion and nuclear thermal propulsion. Beginning in 1990, NASA began a series of interagency planning workshops and meetings to identify key technologies and program priorities for nuclear propulsion. The high-priority, near-term technologies that must be developed to make NEP operational for space exploration include scaling thrusters to higher power, developing high-temperature power processing units, and developing high power, low-mass, long-lived nuclear reactors. 28 refs
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Stirling Technology Development at NASA GRC
Thieme, Lanny G.; Schreiber, Jeffrey G.; Mason, Lee S.
2001-01-01
The Department of Energy, Stirling Technology Company (STC), and NASA Glenn Research Center (NASA Glenn) are developing a free-piston Stirling convertor for a high efficiency Stirling Radioisotope Generator (SRG) for NASA Space Science missions. The SRG is being developed for multimission use, including providing electric power for unmanned Mars rovers and deep space missions. NASA Glenn is conducting an in-house technology project to assist in developing the convertor for space qualification and mission implementation. Recent testing of 55-We Technology Demonstration Convertors (TDCs) built by STC includes mapping of a second pair of TDCs, single TDC testing, and TDC electromagnetic interference and electromagnetic compatibility characterization on a nonmagnetic test stand. Launch environment tests of a single TDC without its pressure vessel to better understand the convertor internal structural dynamics and of dual-opposed TDCs with several engineering mounting structures with different natural frequencies have recently been completed. A preliminary life assessment has been completed for the TDC heater head, and creep testing of the IN718 material to be used for the flight convertors is underway. Long-term magnet aging tests are continuing to characterize any potential aging in the strength or demagnetization resistance of the magnets used in the linear alternator (LA). Evaluations are now beginning on key organic materials used in the LA and piston/rod surface coatings. NASA Glenn is also conducting finite element analyses for the LA, in part to look at the demagnetization margin on the permanent magnets. The world's first known integrated test of a dynamic power system with electric propulsion was achieved at NASA Glenn when a Hall-effect thruster was successfully operated with a free-piston Stirling power source. Cleveland State University is developing a multidimensional Stirling computational fluid dynamics code to significantly improve Stirling loss
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National Aeronautics and Space Administration — NASA Technical Reports Server (NTRS) provides access to aerospace-related citations, full-text online documents, and images and videos. The types of information...
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NASA Technology Demonstrations Missions Program Overview
Turner, Susan
2011-01-01
The National Aeronautics and Space Administration (NASA) Fiscal Year 2010 (FY10) budget introduced a new strategic plan that placed renewed emphasis on advanced missions beyond Earth orbit. This supports NASA s 2011 strategic goal to create innovative new space technologies for our exploration, science, and economic future. As a result of this focus on undertaking many and more complex missions, NASA placed its attention on a greater investment in technology development, and this shift resulted in the establishment of the Technology Demonstrations Missions (TDM) Program. The TDM Program, within the newly formed NASA Office of the Chief Technologist, supports NASA s grand challenges by providing a steady cadence of advanced space technology demonstrations (Figure 1), allowing the infusion of flexible path capabilities for future exploration. The TDM Program's goal is to mature crosscutting capabilities to flight readiness in support of multiple future space missions, including flight test projects where demonstration is needed before the capability can transition to direct mission The TDM Program has several unique criteria that set it apart from other NASA program offices. For instance, the TDM Office matures a small number of technologies that are of benefit to multiple customers to flight technology readiness level (TRL) 6 through relevant environment testing on a 3-year development schedule. These technologies must be crosscutting, which is defined as technology with potential to benefit multiple mission directorates, other government agencies, or the aerospace industry, and they must capture significant public interest and awareness. These projects will rely heavily on industry partner collaboration, and funding is capped for all elements of the flight test demonstration including planning, hardware development, software development, launch costs, ground operations, and post-test assessments. In order to inspire collaboration across government and industry
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Pearce, M. D.
2017-12-01
CCRI is a year-long STEM education program designed to bring together teams of NASA scientists, graduate, undergraduate and high school interns and high school STEM educators to become immersed in NASA research focused on atmospheric and climate changes in the 21st century. GISS climate research combines analysis of global datasets with global models of atmospheric, land surface, and oceanic processes to study climate change on Earth and other planetary atmospheres as a useful tool in assessing our general understanding of climate change. CCRI interns conduct research, gain knowledge in assigned research discipline, develop and present scientific presentations summarizing their research experience. Specifically, CCRI interns write a scientific research paper explaining basic ideas, research protocols, abstract, results, conclusion and experimental design. Prepare and present a professional presentation of their research project at NASA GISS, prepare and present a scientific poster of their research project at local and national research symposiums along with other federal agencies. CCRI Educators lead research teams under the direction of a NASA GISS scientist, conduct research, develop research based learning units and assist NASA scientists with the mentoring of interns. Educators create an Applied Research STEM Curriculum Unit Portfolio based on their research experience integrating NASA unique resources, tools and content into a teacher developed unit plan aligned with the State and NGSS standards. STEM Educators also Integrate and implement NASA unique units and content into their STEM courses during academic year, perform community education STEM engagement events, mentor interns in writing a research paper, oral research reporting, power point design and scientific poster design for presentation to local and national audiences. The CCRI program contributes to the Federal STEM Co-STEM initiatives by providing opportunities, NASA education resources and
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Human Factors Interface with Systems Engineering for NASA Human Spaceflights
Wong, Douglas T.
2009-01-01
This paper summarizes the past and present successes of the Habitability and Human Factors Branch (HHFB) at NASA Johnson Space Center s Space Life Sciences Directorate (SLSD) in including the Human-As-A-System (HAAS) model in many NASA programs and what steps to be taken to integrate the Human-Centered Design Philosophy (HCDP) into NASA s Systems Engineering (SE) process. The HAAS model stresses systems are ultimately designed for the humans; the humans should therefore be considered as a system within the systems. Therefore, the model places strong emphasis on human factors engineering. Since 1987, the HHFB has been engaging with many major NASA programs with much success. The HHFB helped create the NASA Standard 3000 (a human factors engineering practice guide) and the Human Systems Integration Requirements document. These efforts resulted in the HAAS model being included in many NASA programs. As an example, the HAAS model has been successfully introduced into the programmatic and systems engineering structures of the International Space Station Program (ISSP). Success in the ISSP caused other NASA programs to recognize the importance of the HAAS concept. Also due to this success, the HHFB helped update NASA s Systems Engineering Handbook in December 2007 to include HAAS as a recommended practice. Nonetheless, the HAAS model has yet to become an integral part of the NASA SE process. Besides continuing in integrating HAAS into current and future NASA programs, the HHFB will investigate incorporating the Human-Centered Design Philosophy (HCDP) into the NASA SE Handbook. The HCDP goes further than the HAAS model by emphasizing a holistic and iterative human-centered systems design concept.
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Anbari, Allison Brandt; Vogelsmeier, Amy; Dougherty, Debbie S
2017-12-01
Studies that suggest an increased number of bachelor's prepared nurses (BSNs) at the bedside improves patient safety do not stratify their samples into traditional bachelor's and associates (ADN) to BSN graduates. This qualitative study investigated potential differences in patient safety meaning among BSNs and ADN to BSN graduates. Guided by the theory of Language Convergence/Meaning Divergence, interview data from eight BSN and eight ADN to BSN graduates were analyzed. Findings indicate there are two meaning levels or systems, the local level and the systemic level. At the local level, the meaning of patient safety is focused at the patient's bedside and regulated by the nurse. The systemic level included the notion that health system factors such as policies and staffing are paramount to keeping patients safe. More frequently, ADN to BSN graduates' meaning of patient safety was at the local level, while BSNs' meaning centered at the systemic level.
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National Aeronautics and Space Administration — The NASA Earth Exchange (NEX) represents a new platform for the Earth science community that provides a mechanism for scientific collaboration and knowledge sharing....
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NASA Technologies that Benefit Society
Griffin, Amanda
2012-01-01
Applications developed on Earth of technology needed for space flight have produced thousands of spinoffs that contribute to improving national security, the economy, productivity and lifestyle. Over the course of it s history, NASA has nurtured partnerships with the private sector to facilitate the transfer of NASA-developed technology. For every dollar spent on research and development in the space program, it receives back $7 back in the form of corporate and personal income taxes from increased jobs and economic growth. A new technology, known as Liquid-metal alloy, is the result of a project funded by NASA s Jet Propulsion Lab. The unique technology is a blend of titanium, zirconium, nickel, copper and beryllium that achieves a strength greater than titanium. NASA plans to use this metal in the construction of a drill that will help for the search of water beneath the surface of Mars. Many other applications include opportunities in aerospace, defense, military, automotive, medical instrumentation and sporting goods.Developed in the 1980 s, the original Sun Tigers Inc sunlight-filtering lens has withstood the test of time. This technology was first reported in 1987 by NASA s JPL. Two scientists from JPL were later tasked with studying the harmful effects of radiation produced during laser and welding work. They came up with a transparent welding curtain that absorbs, filters and scatters light to maximize protection of human eyes. The two scientists then began doing business as Eagle Eye Optics. Each pair of sunglasses comes complete with ultraviolet protection, dual layer scratch resistant coating, polarized filters for maximum protection against glare and high visual clarity. Sufficient evidence shows that damage to the eye, especially to the retina, starts much earlier than most people realize. Sun filtering sunglasses are important. Winglets seen at the tips of airplane wings are among aviations most visible fuel-saving, performance enhancing technology
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Aerospace Communications Technologies in Support of NASA Mission
Miranda, Felix A.
2016-01-01
NASA is endeavoring in expanding communications capabilities to enable and enhance robotic and human exploration of space and to advance aero communications here on Earth. This presentation will discuss some of the research and technology development work being performed at the NASA Glenn Research Center in aerospace communications in support of NASAs mission. An overview of the work conducted in-house and in collaboration with academia, industry, and other government agencies (OGA) to advance radio frequency (RF) and optical communications technologies in the areas of antennas, ultra-sensitive receivers, power amplifiers, among others, will be presented. In addition, the role of these and other related RF and optical communications technologies in enabling the NASA next generation aerospace communications architecture will be also discussed.
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Pre-Project planning of Capital Facilities at NASA
Barrow, Benjamin John
1999-01-01
This thesis details the development of a NASA specific Project Definition Rating Index (PDRI) tool. This tool is to be used as a checklist for determining the necessary steps to follow in defining project scope and as a means to monitor progress and assess scope definition completeness at various stages during the NASA Pre-Project Planning process. This thesis also describes and identifies specific points in the NASA Capital Facility Programming Cycle for the performance of PDRI assessments ...
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Innovation in NASA's Astrophysics Education and Public Outreach
Hasan, H.; Smith, D.
2014-07-01
New technology and media are being rapidly incorporated in NASA's Astrophysics Education and Public Outreach (EPO) portfolio. In addition to web pages that provide basic information on missions and links to educational sites, missions have developed Facebook and Twitter followers. Recent highlights are presented about the innovative techniques used in presenting NASA science to the public, educators and students, together with representative examples. The immense treasure trove of electronic NASA EPO material is available to the public.
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NASA's Earth Science Data Systems Standards Endorsement Process
National Research Council Canada - National Science Library
Ullman, Richard E; Enloe, Yonsook
2005-01-01
Starting in January 2004, NASA instituted a set of internal working groups to develop ongoing recommendations for the continuing broad evolution of Earth Science Data Systems development and management within NASA...
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Henderson, Brenda
2016-01-01
The presentation highlights NASA's jet noise research for 2016. Jet-noise modeling efforts, jet-surface interactions results, acoustic characteristics of multi-stream jets, and N+2 Supersonic Aircraft system studies are presented.
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NASA's Water Solutions Using Remote Sensing
Toll, David
2012-01-01
NASA Water Resources works within Earth sciences to leverage investments of space-based observation, model results, and development and deployment of enabling technologies, systems, and capabilities into water resources management decision support tools for the sustainable use of water. Earth science satellite observations and modelling products provide a huge volume of valuable data in both near-real-time and extended back nearly 50 years about the Earth's land surface conditions such as land cover type, vegetation type and health, precipitation, snow, soil moisture, and water levels and radiation. Observations of this type combined with models and analysis enable satellite-based assessment of the water cycle. With increasing population pressure and water usage coupled with climate variability and change, water issues are being reported by numerous groups as the most critical environmental problems facing us in the 21st century. Competitive uses and the prevalence of river basins and aquifers that extend across boundaries engender political tensions between communities, stakeholders and countries. The NASA Water Resources Program has the objective to provide NASA products to help deal with these issues with the goal for the sustainable use of water. The Water Resources program organizes its projects under five functional themes: 1) stream-flow and flood forecasting; 2) water consumptive use (includes evapotranspiration) and irrigation; 3) drought; 4) water quality; and 5) climate and water resources. NASA primarily works with national and international groups such as other US government agencies (NOAA, EPA, USGS, USAID) and various other groups to maximize the widest use of the water products. A summary of NASA's water activities linked to helping solve issues for developing countries will be highlighted.
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NASA Armstrong's Approach to Store Separation Analysis
Acuff, Chris; Bui, Trong
2015-01-01
Presentation will an overview of NASA Armstrong's store separation capabilities and how they have been applied recently. Objective of the presentation is to brief Generation Orbit and other potential partners on NASA Armstrong's store separation capabilities. It will include discussions on the use of NAVSEP and Cart3D, as well as some Python scripting work to perform the analysis, and a short overview of this methodology applied to the Towed Glider Air Launch System. Collaboration with potential customers in this area could lead to funding for the further development of a store separation capability at NASA Armstrong, which would boost the portfolio of engineering expertise at the center.
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14 CFR 1201.402 - NASA Industrial Applications Centers.
2010-01-01
... and innovative technology to nonaerospace sectors of the economy—NASA operates a network of Industrial..., Department of Computer Science, Baton Rouge, LA 70813-2065. (b) To obtain access to NASA-developed computer...
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2007 NASA Seal/Secondary Air System Workshop. Volume 1
Steinetz, Bruce M.; Hendricks, Robert C.; Delgado, Irebert
2008-01-01
The 2007 NASA Seal/Secondary Air System workshop covered the following topics: (i) Overview of NASA's new Orion project aimed at developing a new spacecraft that will fare astronauts to the International Space Station, the Moon, Mars, and beyond; (ii) Overview of NASA's fundamental aeronautics technology project; (iii) Overview of NASA Glenn s seal project aimed at developing advanced seals for NASA's turbomachinery, space, and reentry vehicle needs; (iv) Reviews of NASA prime contractor, vendor, and university advanced sealing concepts, test results, experimental facilities, and numerical predictions; and (v) Reviews of material development programs relevant to advanced seals development. Turbine engine studies have shown that reducing seal leakage as well as high-pressure turbine (HPT) blade tip clearances will reduce fuel burn, lower emissions, retain exhaust gas temperature margin, and increase range. Turbine seal development topics covered include a method for fast-acting HPT blade tip clearance control, noncontacting low-leakage seals, intershaft seals, and a review of engine seal performance requirements for current and future Army engine platforms.
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NASA Lunar and Meteorite Sample Disk Program
Foxworth, Suzanne
2017-01-01
The Lunar and Meteorite Sample Disk Program is designed for K-12 classroom educators who work in K-12 schools, museums, libraries, or planetariums. Educators have to be certified to borrow the Lunar and Meteorite Sample Disks by attending a NASA Certification Workshop provided by a NASA Authorized Sample Disk Certifier.
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Functional oligonucleotide recognition nanomodules for electrochemical DNA biosensors
Campàs i Homs, Mònica
2002-01-01
El objetivo de esta tesis ha sido diseñar, caracterizar y optimizar un array de sensores de ADN electroquímico. Para el estudio de la inmovilización de las sondas de oligonucleótidos y la detección de la hibridación se realizaron experimentos preliminares con un sistema simplificado. Dicho sistema demostró que las monocapas auto-ensambladas (SAMs) en superficies de oro eran apropiadas como método de inmovilización. Debido al rápido desarrollo de los sensores de ADN hacia los arrays de ADN, se...
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Flat tie-line power scheduling control of grid-connected hybrid microgrids
DEFF Research Database (Denmark)
Xiao, Zhao xia; Guerrero, Josep M.; Shuang, Jia
2018-01-01
In future active distribution networks (ADNs), microgrids (MGs) may have the possibility to control the power dispatched to the ADN by coordinating the output power of their multiple renewable generation units and energy storage units (ESUs). In this way, each MG may support the active distribution....... Also, a method to calculate the tie-line power flow to be exchanged between the MG and the ADN is explored, and a power ramp rate is given between different dispatch intervals. Finally, a simulation model of the hybrid MG is built and tested. Simulation results show that the proposed hierarchical...
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NASA Risk-Informed Decision Making Handbook
Dezfuli, Homayoon; Stamatelatos, Michael; Maggio, Gaspare; Everett, Christopher; Youngblood, Robert; Rutledge, Peter; Benjamin, Allan; Williams, Rodney; Smith, Curtis; Guarro, Sergio
2010-01-01
This handbook provides guidance for conducting risk-informed decision making in the context of NASA risk management (RM), with a focus on the types of direction-setting key decisions that are characteristic of the NASA program and project life cycles, and which produce derived requirements in accordance with existing systems engineering practices that flow down through the NASA organizational hierarchy. The guidance in this handbook is not meant to be prescriptive. Instead, it is meant to be general enough, and contain a sufficient diversity of examples, to enable the reader to adapt the methods as needed to the particular decision problems that he or she faces. The handbook highlights major issues to consider when making decisions in the presence of potentially significant uncertainty, so that the user is better able to recognize and avoid pitfalls that might otherwise be experienced.
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NASA Developments in Personnel Protective Equipment
Graf, John
2015-01-01
NASA has some unique and challenging PPE needs: there are credible threats to air quality (fire, ammonia leak, hydrazine leak)that require a contingency breathing apparatus that operates for many hours - but there is not enough space or up-mass to provide supplied air tanks. We cannot use "Scott Air Tanks" commonly used by firefighters and other first responders. NASA has developed a respirator based emergency breathing device. It uses a "one size fits everybody in the astronaut corps" hooded mask with excellent chemical permeability and fire resistance properties, and a filtering respirator cartridge that protects the wearer from ammonia leaks, hydrazine leaks, or products of combustion. If you need a small, lightweight emergency breathing system that lasts longer than a supplied air system, we should meet and learn if NASA sponsored technology development can help.
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NASA, Engineering, and Swarming Robots
Leucht, Kurt
2015-01-01
This presentation is an introduction to NASA, to science and engineering, to biologically inspired robotics, and to the Swarmie ant-inspired robot project at KSC. This presentation is geared towards elementary school students, middle school students, and also high school students. This presentation is suitable for use in STEM (science, technology, engineering, and math) outreach events. The first use of this presentation will be on Oct 28, 2015 at Madison Middle School in Titusville, Florida where the author has been asked by the NASA-KSC Speakers Bureau to speak to the students about the Swarmie robots.
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77 FR 13153 - Information Collection; NASA Contractor Financial Management Reports
2012-03-05
..., [email protected] . SUPPLEMENTARY INFORMATION: I. Abstract The NASA Contractor Financial Management... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-019] Information Collection; NASA Contractor Financial Management Reports AGENCY: National Aeronautics and Space Administration (NASA). ACTION...
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14 CFR 1245.109 - Assignment of title to NASA.
2010-01-01
... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Assignment of title to NASA. 1245.109... INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.109 Assignment of title to NASA. (a) The instrument of waiver set forth in § 1245.115(c) shall be voided by NASA with respect to the domestic title to...
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Complete NASA Dryden Staff of 1985, in front of building 4800
1985-01-01
In 1985 the NASA Ames-Dryden Flight Research Facility employees and contractors gathered around the base of the X-1E for a picture. The X-1E is mounted in front of building 4800, the main building at Dryden. On Wednesday, October 1, 1958, the NACA yellow-backed winged symbol (see E-33718) that represented the National Advisory Committee for Aeronautics for 43-years, was removed from the front of the main building at the NASA High Speed Flight Station, making room for a new insignia belonging to the National Aeronautics and Space Administration. This NASA Insignia was created by retiree James J. Modarelli, former Chief of Technical Publication of Lewis Research Center; designed by the Army Institute of Heraldry; and approved by the Commission of Fine Arts and the NASA Administrator. This official insignia of the NASA is a dark blue disc with white stars. The white hand-cut letters 'NASA' are in the center of the disc and are encircled by a white diagonal orbit. A solid red 'V' shape appears behind and in front of the letters and extends beyond the disc. The 'V' is patterned after an actual wing design being tested by NACA researchers during the late 1950s. This insignia was used from 1958 to 1975 and was affectionately known at the 'meatball,' returning to NASA Insignia status in 1992. In the photo above the NASA Logotype appearing on the front of the main building replaced the NASA Insignia. The NASA Logotype was developed under the Federal Design Improvement Program initiated by the President in 1972, with the preferred color being red. It was approved by the Commission of Fine Arts and the NASA Administrator in October 1975. It symbolized NASA's role in aeronautics and space from 1975 to 1992 and has since been retired. In the logotype, the letters 'NASA' are reduced with the strokes being of one width; the elimination of cross strokes in the two 'A' letters imparts a quality of uniqueness and contemporary character. This familiar logo was known as 'The Worm'. On
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1998 NASA-ASEE-Stanford Summer Faculty Fellowship Program
1998-01-01
This report presents the essential features and highlights of the 1998 Summer Faculty Fellowship Program at Ames Research Center and Dryden Flight Research Center in a comprehensive and concise form. Summary reports describing the fellows' technical accomplishments are enclosed in the attached technical report. The proposal for the 1999 NASA-ASEE-Stanford Summer Faculty Fellowship Program is being submitted under separate cover. Of the 31 participating fellows, 27 were at Ames and 4 were at Dryden. The Program's central feature is the active participation by each fellow in one of the key technical activities currently under way at either the NASA Ames Research Center or the NASA Dryden Flight Research Center. The research topic is carefully chosen in advance to satisfy the criteria of: (1) importance to NASA, (2) high technical level, and (3) a good match to the interests, ability, and experience of the fellow, with the implied possibility of NASA-supported follow-on work at the fellow's home institution. Other features of the Summer Faculty Fellowship Program include participation by the fellows in workshops and seminars at Stanford, the Ames Research Center, and other off-site locations. These enrichment programs take place either directly or remotely, via the Stanford Center for Professional Development, and also involve specific interactions between fellows and Stanford faculty on technical and other academic subjects. A few, brief remarks are in order to summarize the fellows' opinions of the summer program. It is noteworthy that 90% of the fellows gave the NASA-Ames/Dryden- Stanford program an "excellent" rating and the remaining 10%, "good." Also, 100% would recommend the program to their colleagues as an effective means of furthering their professional development as teachers and researchers. Last, but not least, 87% of the fellows stated that a continuing research relationship with their NASA colleagues' organization probably would be maintained. Therefore
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NASA's Astrophysics Data Archives
Hasan, H.; Hanisch, R.; Bredekamp, J.
2000-09-01
The NASA Office of Space Science has established a series of archival centers where science data acquired through its space science missions is deposited. The availability of high quality data to the general public through these open archives enables the maximization of science return of the flight missions. The Astrophysics Data Centers Coordinating Council, an informal collaboration of archival centers, coordinates data from five archival centers distiguished primarily by the wavelength range of the data deposited there. Data are available in FITS format. An overview of NASA's data centers and services is presented in this paper. A standard front-end modifyer called `Astrowbrowse' is described. Other catalog browsers and tools include WISARD and AMASE supported by the National Space Scince Data Center, as well as ISAIA, a follow on to Astrobrowse.
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NASA Operational Environment Team (NOET) - NASA's key to environmental technology
Cook, Beth
1993-01-01
NOET is a NASA-wide team which supports the research and development community by sharing information both in person and via a computerized network, assisting in specification and standard revisions, developing cleaner propulsion systems, and exploring environmentally compliant alternatives to current processes. NOET's structure, dissemination of materials, electronic information, EPA compliance, specifications and standards, and environmental research and development are discussed.
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NASA Remote Sensing Data for Epidemiological Studies
Maynard, Nancy G.; Vicente, G. A.
2002-01-01
In response to the need for improved observations of environmental factors to better understand the links between human health and the environment, NASA has established a new program to significantly improve the utilization of NASA's diverse array of data, information, and observations of the Earth for health applications. This initiative, lead by Goddard Space Flight Center (GSFC) has the following goals: (1) To encourage interdisciplinary research on the relationships between environmental parameters (e.g., rainfall, vegetation) and health, (2) Develop practical early warning systems, (3) Create a unique system for the exchange of Earth science and health data, (4) Provide an investigator field support system for customers and partners, (5) Facilitate a system for observation, identification, and surveillance of parameters relevant to environment and health issues. The NASA Environment and Health Program is conducting several interdisciplinary projects to examine applications of remote sensing data and information to a variety of health issues, including studies on malaria, Rift Valley Fever, St. Louis Encephalitis, Dengue Fever, Ebola, African Dust and health, meningitis, asthma, and filariasis. In addition, the NASA program is creating a user-friendly data system to help provide the public health community with easy and timely access to space-based environmental data for epidemiological studies. This NASA data system is being designed to bring land, atmosphere, water and ocean satellite data/products to users not familiar with satellite data/products, but who are knowledgeable in the Geographic Information Systems (GIS) environment. This paper discusses the most recent results of the interdisciplinary environment-health research projects and provides an analysis of the usefulness of the satellite data to epidemiological studies. In addition, there will be a summary of presently-available NASA Earth science data and a description of how it may be obtained.
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National Aeronautics and Space Administration — NASA has released a series of space sounds via sound cloud. We have abstracted away some of the hassle in accessing these sounds, so that developers can play with...
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NASA Administrative Data Base Management Systems, 1984
Radosevich, J. D. (Editor)
1984-01-01
Strategies for converting to a data base management system (DBMS) and the implementation of the software packages necessary are discussed. Experiences with DBMS at various NASA centers are related including Langley's ADABAS/NATURAL and the NEMS subsystem of the NASA metrology informaton system. The value of the integrated workstation with a personal computer is explored.
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77 FR 41203 - NASA International Space Station Advisory Committee; Meeting
2012-07-12
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-057] NASA International Space Station Advisory Committee; Meeting AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of..., the National Aeronautics and Space Administration announces an open meeting of the NASA International...
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78 FR 77502 - NASA International Space Station Advisory Committee; Meeting
2013-12-23
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (13-154)] NASA International Space Station Advisory Committee; Meeting AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of..., the National Aeronautics and Space Administration announces a meeting of the NASA International Space...
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77 FR 2765 - NASA International Space Station Advisory Committee; Meeting
2012-01-19
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (12-003)] NASA International Space Station Advisory Committee; Meeting AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of..., the National Aeronautics and Space Administration announces an open meeting of the NASA International...
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77 FR 66082 - NASA International Space Station Advisory Committee; Meeting
2012-11-01
... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-090] NASA International Space Station Advisory Committee; Meeting AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of..., the National Aeronautics and Space Administration announces an open meeting of the NASA International...
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NASA tells physicists to aim for the stars
MacIlwain, C
1999-01-01
Dan Goldin, administrator at NASA, suggested that the next generation of instruments for high-energy physics research should be built in space. This did not go down well at Fermilab where a case is being made for a new ground-based accelerator. Goldin's aim though was simply to tell the scientific community that NASA is prepared to spend big money on physics in space. NASA also wants to work more closely with the DOE and the NSF to support space-based experiments (1 page).
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78 FR 11235 - Information Collection Notice/NASA Great Moonbuggy Race
2013-02-15
... and Space Administration published a notice in the Federal Register of January 28, 2013, inviting the... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-013] Information Collection Notice/NASA Great Moonbuggy Race AGENCY: National Aeronautics and Space Administration (NASA). ACTION: NASA...
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Bringing NASA Technology Down to Earth
Lockney, Daniel P.; Taylor, Terry L.
2018-01-01
Whether putting rovers on Mars or sustaining life in extreme conditions, NASA develops technologies to solve some of the most difficult challenges ever faced. Through its Technology Transfer Program, the agency makes the innovations behind space exploration available to industry, academia, and the general public. This paper describes the primary mechanisms through which NASA disseminates technology to solve real-life problems; illustrates recent program accomplishments; and provides examples of spinoff success stories currently impacting everyday life.
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NASA Customer Data and Operations System
Butler, Madeline J.; Stallings, William H.
1991-01-01
In addition to the currently provided NASA services such as Communications and Tracking and Data Relay Satellite System services, the NASA's Customer Data and Operations System (CDOS) will provide the following services to the user: Data Delivery Service, Data Archive Service, and CDOS Operations Management Service. This paper describes these services in detail and presents respective block diagrams. The CDOS services will support a variety of multipurpose missions simultaneously with centralized and common hardware and software data-driven systems.