WorldWideScience

Sample records for nanofabrication from ultralarge-scale integration

  1. Inferring the choreography of parental genomes during fertilization from ultralarge-scale whole-transcriptome analysis.

    Science.gov (United States)

    Park, Sung-Joon; Komata, Makiko; Inoue, Fukashi; Yamada, Kaori; Nakai, Kenta; Ohsugi, Miho; Shirahige, Katsuhiko

    2013-12-15

    Fertilization precisely choreographs parental genomes by using gamete-derived cellular factors and activating genome regulatory programs. However, the mechanism remains elusive owing to the technical difficulties of preparing large numbers of high-quality preimplantation cells. Here, we collected >14 × 10(4) high-quality mouse metaphase II oocytes and used these to establish detailed transcriptional profiles for four early embryo stages and parthenogenetic development. By combining these profiles with other public resources, we found evidence that gene silencing appeared to be mediated in part by noncoding RNAs and that this was a prerequisite for post-fertilization development. Notably, we identified 817 genes that were differentially expressed in embryos after fertilization compared with parthenotes. The regulation of these genes was distinctly different from those expressed in parthenotes, suggesting functional specialization of particular transcription factors prior to first cell cleavage. We identified five transcription factors that were potentially necessary for developmental progression: Foxd1, Nkx2-5, Sox18, Myod1, and Runx1. Our very large-scale whole-transcriptome profile of early mouse embryos yielded a novel and valuable resource for studies in developmental biology and stem cell research. The database is available at http://dbtmee.hgc.jp.

  2. Constraining cosmological ultra-large scale structure using numerical relativity

    CERN Document Server

    Braden, Jonathan; Peiris, Hiranya V; Aguirre, Anthony

    2016-01-01

    Cosmic inflation, a period of accelerated expansion in the early universe, can give rise to large amplitude ultra-large scale inhomogeneities on distance scales comparable to or larger than the observable universe. The cosmic microwave background (CMB) anisotropy on the largest angular scales is sensitive to such inhomogeneities and can be used to constrain the presence of ultra-large scale structure (ULSS). We numerically evolve nonlinear inhomogeneities present at the beginning of inflation in full General Relativity to assess the CMB quadrupole constraint on the amplitude of the initial fluctuations and the size of the observable universe relative to a length scale characterizing the ULSS. To obtain a statistically significant number of simulations, we adopt a toy model in which inhomogeneities are injected along a preferred direction. We compute the likelihood function for the CMB quadrupole including both ULSS and the standard quantum fluctuations produced during inflation. We compute the posterior given...

  3. Constraining cosmological ultralarge scale structure using numerical relativity

    Science.gov (United States)

    Braden, Jonathan; Johnson, Matthew C.; Peiris, Hiranya V.; Aguirre, Anthony

    2017-07-01

    Cosmic inflation, a period of accelerated expansion in the early universe, can give rise to large amplitude ultralarge scale inhomogeneities on distance scales comparable to or larger than the observable universe. The cosmic microwave background (CMB) anisotropy on the largest angular scales is sensitive to such inhomogeneities and can be used to constrain the presence of ultralarge scale structure (ULSS). We numerically evolve nonlinear inhomogeneities present at the beginning of inflation in full general relativity to assess the CMB quadrupole constraint on the amplitude of the initial fluctuations and the size of the observable universe relative to a length scale characterizing the ULSS. To obtain a statistically meaningful ensemble of simulations, we adopt a toy model in which inhomogeneities are injected along a preferred direction. We compute the likelihood function for the CMB quadrupole including both ULSS and the standard quantum fluctuations produced during inflation. We compute the posterior given the observed CMB quadrupole, finding that when including gravitational nonlinearities, ULSS curvature perturbations of order unity are allowed by the data, even on length scales not too much larger than the size of the observable universe. To demonstrate the robustness of our conclusions, we also explore a semianalytic model for the ULSS which reproduces our numerical results for the case of planar symmetry, and which can be extended to ULSS with a three-dimensional inhomogeneity structure. Our results illustrate the utility and importance of numerical relativity for constraining early universe cosmology.

  4. Observational signatures of modified gravity on ultra-large scales

    CERN Document Server

    Baker, Tessa

    2015-01-01

    Extremely large surveys with future experiments like Euclid and the SKA will soon allow us to access perturbation modes close to the Hubble scale, with wavenumbers $k \\sim {\\cal H}$. If a modified gravity theory is responsible for cosmic acceleration, the Hubble scale is a natural regime for deviations from General Relativity (GR) to become manifest. The majority of studies to date have concentrated on the consequences of alternative gravity theories for the subhorizon, quasi-static regime, however. We investigate how modifications to the gravitational field equations affect perturbations around the Hubble scale, and how this translates into deviations of ultra large-scale relativistic observables from their GR behaviour. Adopting a model-independent ethos that relies only on the broad physical properties of gravity theories, we find that the deviations of the observables are small unless modifications to GR are drastic. The angular dependence and redshift evolution of the deviations is highly parameterisatio...

  5. Ultra-large scale cosmology with next-generation experiments

    CERN Document Server

    Alonso, David; Ferreira, Pedro G; Maartens, Roy; Santos, Mario G

    2015-01-01

    Future surveys of large-scale structure will be able to measure perturbations on the scale of the cosmological horizon, and so could potentially probe a number of novel relativistic effects that are negligibly small on sub-horizon scales. These effects leave distinctive signatures in the power spectra of clustering observables and, if measurable, would open a new window on relativistic cosmology. We quantify the size and detectability of the effects for a range of future large-scale structure surveys: spectroscopic and photometric galaxy redshift surveys, intensity mapping surveys of neutral hydrogen, and continuum surveys of radio galaxies. Our forecasts show that next-generation experiments, reaching out to redshifts z ~ 4, will not be able to detect previously-undetected general-relativistic effects from the single-tracer power spectra alone, although they may be able to measure the lensing magnification in the auto-correlation. We also perform a rigorous joint forecast for the detection of primordial non-...

  6. Nanofabrication of Metallic Nanostructures and Integration with Light Detection Devices

    Science.gov (United States)

    Huang, Liang

    Metallic nanostructures have been investigated with various applications especially for integration with light detection devices. The incident light can be manipulated by those nanostructures to enhance light absorption therefor improve device performance. However, previous studies focused on optical design. The electrical properties of these integrated light detection devices have not been fully considered. The photon generated carriers transport and collection are critical for light detection devices as well. An optimized device platform considering from both the optical and electrical aspects to fully utilize these nanostructures is highly desired for future light detection devices. This dissertation targeted on three objectives, beginning with the fabrication process development of various nanostructures on different substrates. High quality nanostructures were achieved with minimum 20nm gap and 45nm line width. The second objective was developing the metallic fishnet nanostructures integrated Schottky contact a-Si solar cell to improve both light absorption and photon generated carrier collection. The fishnet was designed as the light trapping structure and 2D connected top contact to collect carriers. The third objective was developing metallic nanostructures integrated GeSn photodetectors. The H shape nano antennas were integrated on GeSn photodetectors. Multiple resonant absorption peaks at infrared range were observed using spectroscopic ellipsometry. However, there was no obvious photoresponse value improvement of developed solar cells and H shape antennas integrated GeSn photodetectors. For further investigation, interdigitated electrodes integrated GeSn photodetectors were designed. With less carrier transit time, the responsivity value of the integrated Ge0.991Sn0.009 photodetector was 72muA/W at 1.55mum at room temperature which was 6 times higher comparing to device without integration. Meanwhile, with the increased carrier life time by decreasing

  7. DNA nanostructure meets nanofabrication.

    Science.gov (United States)

    Zhang, Guomei; Surwade, Sumedh P; Zhou, Feng; Liu, Haitao

    2013-04-07

    Recent advances in DNA nanotechnology have made it possible to construct DNA nanostructures of almost arbitrary shapes with 2-3 nm of precision in their dimensions. These DNA nanostructures are ideal templates for bottom-up nanofabrication. This review highlights the challenges and recent advances in three areas that are directly related to DNA-based nanofabrication: (1) fabrication of large scale DNA nanostructures; (2) pattern transfer from DNA nanostructure to an inorganic substrate; and (3) directed assembly of DNA nanostructures.

  8. From cleanroom to desktop: emerging micro-nanofabrication technology for biomedical applications.

    Science.gov (United States)

    Pan, Tingrui; Wang, Wei

    2011-02-01

    This review is motivated by the growing demand for low-cost, easy-to-use, compact-size yet powerful micro-nanofabrication technology to address emerging challenges of fundamental biology and translational medicine in regular laboratory settings. Recent advancements in the field benefit considerably from rapidly expanding material selections, ranging from inorganics to organics and from nanoparticles to self-assembled molecules. Meanwhile a great number of novel methodologies, employing off-the-shelf consumer electronics, intriguing interfacial phenomena, bottom-up self-assembly principles, etc., have been implemented to transit micro-nanofabrication from a cleanroom environment to a desktop setup. Furthermore, the latest application of micro-nanofabrication to emerging biomedical research will be presented in detail, which includes point-of-care diagnostics, on-chip cell culture as well as bio-manipulation. While significant progresses have been made in the rapidly growing field, both apparent and unrevealed roadblocks will need to be addressed in the future. We conclude this review by offering our perspectives on the current technical challenges and future research opportunities.

  9. From Cleanroom to Desktop: Emerging Micro-Nanofabrication Technology for Biomedical Applications

    Science.gov (United States)

    Wang, Wei

    2010-01-01

    This review is motivated by the growing demand for low-cost, easy-to-use, compact-size yet powerful micro-nanofabrication technology to address emerging challenges of fundamental biology and translational medicine in regular laboratory settings. Recent advancements in the field benefit considerably from rapidly expanding material selections, ranging from inorganics to organics and from nanoparticles to self-assembled molecules. Meanwhile a great number of novel methodologies, employing off-the-shelf consumer electronics, intriguing interfacial phenomena, bottom-up self-assembly principles, etc., have been implemented to transit micro-nanofabrication from a cleanroom environment to a desktop setup. Furthermore, the latest application of micro-nanofabrication to emerging biomedical research will be presented in detail, which includes point-of-care diagnostics, on-chip cell culture as well as bio-manipulation. While significant progresses have been made in the rapidly growing field, both apparent and unrevealed roadblocks will need to be addressed in the future. We conclude this review by offering our perspectives on the current technical challenges and future research opportunities. PMID:21161384

  10. Ultra-large scale synthesis of high electrochemical performance SnO{sub 2} quantum dots within 5 min at room temperature following a growth self-termination mechanism

    Energy Technology Data Exchange (ETDEWEB)

    Cui, Hongtao, E-mail: htcui@ytu.edu.cn; Xue, Junying; Ren, Wanzhong; Wang, Minmin

    2015-10-05

    Highlights: • SnO{sub 2} quantum dots were prepared at an ultra-large scale at room temperature within 5 min. • The grinding of SnCl{sub 2}⋅2H{sub 2}O and ammonium persulphate with morpholine produces quantum dots. • The reactions were self-terminated through the rapid consumption of water. • The obtained SnO{sub 2} quantum dots own high electrochemical performance. - Abstract: SnO{sub 2} quantum dots are prepared at an ultra-large scale by a productive synthetic procedure without using any organic ligand. The grinding of solid mixture of SnCl{sub 2}⋅2H{sub 2}O and ammonium persulphate with morpholine in a mortar at room temperature produces 1.2 nm SnO{sub 2} quantum dots within 5 min. The formation of SnO{sub 2} is initiated by the reaction between tin ions and hydroxyl groups generated from hydrolysis of morpholine in the released hydrate water from SnCl{sub 2}⋅2H{sub 2}O. It is considered that as water is rapidly consumed by the hydrolysis reaction of morpholine, the growth process of particles is self-terminated immediately after their transitory period of nucleation and growth. As a result of simple procedure and high toleration to scaling up of preparation, at least 50 g of SnO{sub 2} quantum dots can be produced in one batch in our laboratory. The as prepared quantum dots present high electrochemical performance due to the effective faradaic reaction and the alternative trapping of electrons and holes.

  11. Nanofabrication principles, capabilities and limits

    CERN Document Server

    Cui, Zheng

    2017-01-01

    This second edition of Nanofabrication is one of the most comprehensive introductions on nanofabrication technologies and processes. A practical guide and reference, this book introduces readers to all of the developed technologies that are capable of making structures below 100nm. The principle of each technology is introduced and illustrated with minimum mathematics involved. Also analyzed are the capabilities of each technology in making sub-100nm structures, and the limits of preventing a technology from going further down the dimensional scale. This book provides readers with a toolkit that will help with any of their nanofabrication challenges.

  12. A coordination model for ultra-large scale systems of systems

    Directory of Open Access Journals (Sweden)

    Manuela L. Bujorianu

    2013-11-01

    Full Text Available The ultra large multi-agent systems are becoming increasingly popular due to quick decay of the individual production costs and the potential of speeding up the solving of complex problems. Examples include nano-robots, or systems of nano-satellites for dangerous meteorite detection, or cultures of stem cells for organ regeneration or nerve repair. The topics associated with these systems are usually dealt within the theories of intelligent swarms or biologically inspired computation systems. Stochastic models play an important role and they are based on various formulations of the mechanical statistics. In these cases, the main assumption is that the swarm elements have a simple behaviour and that some average properties can be deduced for the entire swarm. In contrast, complex systems in areas like aeronautics are formed by elements with sophisticated behaviour, which are even autonomous. In situations like this, a new approach to swarm coordination is necessary. We present a stochastic model where the swarm elements are communicating autonomous systems, the coordination is separated from the component autonomous activity and the entire swarm can be abstracted away as a piecewise deterministic Markov process, which constitutes one of the most popular model in stochastic control. Keywords: ultra large multi-agent systems, system of systems, autonomous systems, stochastic hybrid systems.

  13. Micro/nanofabricated solid-state thermoelectric generator devices for integrated high voltage power sources

    Science.gov (United States)

    Fleurial, J. P.; Snyder, G. J.; Patel, J.; Huang, C. K.; Ryan, M. A.; Averback, R.; Chen, G.; Hill, C.

    2002-01-01

    The Jet Propulsion Laboratory has been actively pursuing the development of thermoelectric micro/nanodevices that can be fabricated using a combination of electrochemical deposition and integrated circuit processing techniques.

  14. Micro/nanofabricated solid-state thermoelectric generator devices for integrated high voltage power sources

    Science.gov (United States)

    Fleurial, J. P.; Snyder, G. J.; Patel, J.; Huang, C. K.; Ryan, M. A.; Averback, R.; Chen, G.; Hill, C.

    2002-01-01

    The Jet Propulsion Laboratory has been actively pursuing the development of thermoelectric micro/nanodevices that can be fabricated using a combination of electrochemical deposition and integrated circuit processing techniques.

  15. Nanofabrication of SERS device by an integrated block-copolymer and nanoimprint lithography method.

    Energy Technology Data Exchange (ETDEWEB)

    Nealey, Paul (University of Wisconsin); Liu, Charlie (University of Wisconsin); Skinner, Jack L.; Yang, Elaine; Steinhaus, Charles A.; Yang, Chu-Yeu Peter

    2010-05-01

    The integration of block-copolymers (BCPs) and nanoimprint lithography (NIL) presents a novel and cost-effective approach to achieving nanoscale patterning capabilities. The authors demonstrate the fabrication of a surface-enhanced Raman scattering device using templates created by the BCP-NIL integrated method. The method utilizes a poly(styrene-block-methyl methacrylate) cylindrical-forming diblock-copolymer as a masking material to create a Si template, which is then used to perform a thermal imprint of a poly(methyl methacrylate) (PMMA) layer on a Si substrate. Au with a Cr adhesion layer was evaporated onto the patterned PMMA and the subsequent lift-off resulted in an array of nanodots. Raman spectra collected for samples of R6G on Si substrates with and without patterned nanodots showed enhancement of peak intensities due to the presence of the nanodot array. The demonstrated BCP-NIL fabrication method shows promise for cost-effective nanoscale fabrication of plasmonic and nanoelectronic devices.

  16. From nanofabrication to self-fabrication--tailored chemistry for control of single molecule electronic devices

    DEFF Research Database (Denmark)

    Moth-Poulsen, Kasper; Bjørnholm, Thomas

    2010-01-01

    as alternatives to the dominant top-down nanofabrication techniques. One example is solution-based self-assembly of a molecule enclosed by two gold nanorod electrodes. This article will discuss recent attempts to control the self-assembly process by the use of supramolecular chemistry and how to tailor......Single molecule electronics is a field of research focused on the use of single molecules as electronics components. During the past 15 years the field has concentrated on development of test beds for measurements on single molecules. Bottom-up approaches to single molecule devices are emerging...

  17. Gravity at the horizon: on relativistic effects, CMB-LSS correlations and ultra-large scales in Horndeski's theory

    Science.gov (United States)

    Renk, Janina; Zumalacárregui, Miguel; Montanari, Francesco

    2016-07-01

    We address the impact of consistent modifications of gravity on the largest observable scales, focusing on relativistic effects in galaxy number counts and the cross-correlation between the matter large scale structure (LSS) distribution and the cosmic microwave background (CMB). Our analysis applies to a very broad class of general scalar-tensor theories encoded in the Horndeski Lagrangian and is fully consistent on linear scales, retaining the full dynamics of the scalar field and not assuming quasi-static evolution. As particular examples we consider self-accelerating Covariant Galileons, Brans-Dicke theory and parameterizations based on the effective field theory of dark energy, using the hi class code to address the impact of these models on relativistic corrections to LSS observables. We find that especially effects which involve integrals along the line of sight (lensing convergence, time delay and the integrated Sachs-Wolfe effect—ISW) can be considerably modified, and even lead to O(1000%) deviations from General Relativity in the case of the ISW effect for Galileon models, for which standard probes such as the growth function only vary by O(10%). These effects become dominant when correlating galaxy number counts at different redshifts and can lead to ~ 50% deviations in the total signal that might be observable by future LSS surveys. Because of their integrated nature, these deep-redshift cross-correlations are sensitive to modifications of gravity even when probing eras much before dark energy domination. We further isolate the ISW effect using the cross-correlation between LSS and CMB temperature anisotropies and use current data to further constrain Horndeski models. Forthcoming large-volume galaxy surveys using multiple-tracers will search for all these effects, opening a new window to probe gravity and cosmic acceleration at the largest scales available in our universe.

  18. Nanofabrication of Hybrid Optoelectronic Devices

    Science.gov (United States)

    Dibos, Alan Michael

    The material requirements for optoelectronic devices can vary dramatically depending on the application. Often disparate material systems need to be combined to allow for full device functionality. At the nanometer scale, this can often be challenging because of the inherent chemical and structural incompatibilities of nanofabrication. This dissertation concerns the integration of seemingly dissimilar materials into hybrid optoelectronic devices for photovoltaic, plasmonic, and photonic applications. First, we show that combining a single strip of conjugated polymer and inorganic nanowire can yield a nanoscale solar cell, and modeling of optical absorption and exciton diffusion in this device can provide insight into the efficiency of charge separation. Second, we use an on-chip nanowire light emitting diode to pump a colloidal quantum dot coupled to a silver waveguide. The resulting device is an electro-optic single plasmon source. Finally, we transfer diamond waveguides onto near-field avalanche photodiodes fabricated from GaAs. Embedded in the diamond waveguides are nitrogen vacancy color centers, and the mapping of emission from these single-photon sources is demonstrated using our on-chip detectors, eliminating the need for external photodetectors on an optical table. These studies show the promise of hybrid optoelectronic devices at the nanoscale with applications in alternative energy, optical communication, and quantum optics.

  19. Micro/nanofabricated environments for synthetic biology.

    Science.gov (United States)

    Collier, C Patrick; Simpson, Michael L

    2011-08-01

    A better understanding of how confinement, crowding and reduced dimensionality modulate reactivity and reaction dynamics will aid in the rational and systematic discovery of functionality in complex biological systems. Artificial microfabricated and nanofabricated structures have helped elucidate the effects of nanoscale spatial confinement and segregation on biological behavior, particularly when integrated with microfluidics, through precise control in both space and time of diffusible signals and binding interactions. Examples of nanostructured interfaces for synthetic biology include the development of cell-like compartments for encapsulating biochemical reactions, nanostructured environments for fundamental studies of diffusion, molecular transport and biochemical reaction kinetics, and regulation of biomolecular interactions as functions of microfabricated and nanofabricated topological constraints.

  20. Gravity at the horizon: on relativistic effects, CMB-LSS correlations and ultra-large scales in Horndeski's theory

    CERN Document Server

    Renk, Janina; Montanari, Francesco

    2016-01-01

    Observations of cosmological large scale structures (LSS) offer a unique opportunity to test the nature of gravity. We address the impact of consistent modifications of gravity on the largest observable scales, focusing on relativistic effects in galaxy number counts and the cross-correlation between the matter distribution and the cosmic microwave background temperature anisotropies. Our analysis applies to a very broad class of general scalar-tensor theories encoded in the Horndeski Lagrangian and is fully consistent on linear scales, retaining the full dynamics of the scalar field and not assuming quasi-static evolution. As particular examples we consider both, self-accelerating covariant Galileons and parameterizations of the properties that fully describe the linear theory. We investigate the impact of these models on relativistic corrections to galaxy clustering using the hi_class code. We find that especially effects which involve integrals along the line of sight (gravitational lensing, time delay and...

  1. Zooming in to see the bigger picture: microfluidic and nanofabrication tools to study bacteria.

    Science.gov (United States)

    Hol, Felix J H; Dekker, Cees

    2014-10-24

    The spatial structure of natural habitats strongly affects bacterial life, ranging from nanoscale structural features that individual cells exploit for surface attachment, to micro- and millimeter-scale chemical gradients that drive population-level processes. Nanofabrication and microfluidics are ideally suited to manipulate the environment at those scales and have emerged as powerful tools with which to study bacteria. Here, we review the new scientific insights gained by using a diverse set of nanofabrication and microfluidic techniques to study individual bacteria and multispecies communities. This toolbox is beginning to elucidate disparate bacterial phenomena-including aging, electron transport, and quorum sensing-and enables the dissection of environmental communities through single-cell genomics. A more intimate integration of microfluidics, nanofabrication, and microbiology will enable further exploration of bacterial life at the smallest scales. Copyright © 2014, American Association for the Advancement of Science.

  2. Progression in the Fountain Pen Approach: From 2D Writing to 3D Free-Form Micro/Nanofabrication.

    Science.gov (United States)

    Je, Jung Ho; Kim, Jong-Man; Jaworski, Justyn

    2017-01-01

    The fountain pen approach, as a means for transferring materials to substrates, has shown numerous incarnations in recent years for creating 2D micro/nanopatterns and even generating 3D free-form nanostructures using a variety of material "inks". While the idea of filled reservoirs used to deliver material to a substrate via a capillary remains unchanged since antiquity, the advent of precise micromanipulation systems and functional material "inks" allows the extension of this mechanism to more high-tech applications. Herein, the recent growth in meniscus guided fountain pen approaches for benchtop micro/nanofabrication, which has occurred in the last decade, is discussed. Particular attention is given to the theory, equipment, and experimentation encompassing this unique direct writing approach. A detailed exploration of the diverse ink systems and functional device applications borne from this strategy is put forth to reveal its rapid expansion to a broad range of scientific and engineering disciplines. As such, this informative review is provided for researchers considering adoption of this recent advancement of a familiar technology.

  3. DNA-templated nanofabrication.

    Science.gov (United States)

    Becerril, Héctor A; Woolley, Adam T

    2009-02-01

    Nanofabrication, or the organizational control over matter at the nanometre scale, is an intriguing scientific challenge requiring multidisciplinary tools for its solution. DNA is a biomolecule that can be combined with other nanometre-scale entities through chemical self-assembly to form a broad variety of nanomaterials. In this tutorial review we present the principles that allow DNA to interact with other chemical species, and describe the challenges and potential applications of DNA as a template for making both biological and inorganic features with nanometre resolution. As such, this report should be of interest to chemists, surface and materials scientists, biologists, and nanotechnologists, as well as others who seek to use DNA in nanofabrication.

  4. MicroChannel Reactors for ISRU Applications Using Nanofabricated Catalysts

    Science.gov (United States)

    Carranza, Susana; Makel, Darby B.; Vander Wal, Randall L.; Berger, Gordon M.; Pushkarev, Vladimir V.

    2006-01-01

    With the new direction of NASA to emphasize the exploration of the Moon, Mars and beyond, quick development and demonstration of efficient systems for In-Situ Resources Utilization (ISRU) is more critical and timely than ever before. Affordable planning and execution of prolonged manned space missions depend upon the utilization of local resources and the waste products which are formed in manned spacecraft and surface bases. This paper presents current development of miniaturized chemical processing systems that combine microchannel reactor design with nanofabricated catalysts. Carbon nanotubes (CNT) are used to produce a nanostructure within microchannel reactors, as support for catalysts. By virtue of their nanoscale dimensions, nanotubes geometrically restrict the catalyst particle size that can be supported upon the tube walls. By confining catalyst particles to sizes smaller than the CNT diameter, a more uniform catalyst particle size distribution may be maintained. The high dispersion permitted by the vast surface area of the nanoscale material serves to retain the integrity of the catalyst by reducing sintering or coalescence. Additionally, catalytic efficiency increases with decreasing catalyst particle size (reflecting higher surface area per unit mass) while chemical reactivity frequently is enhanced at the nanoscale. Particularly significant is the catalyst exposure. Rather than being confined within a porous material or deposited upon a 2-d surface, the catalyst is fully exposed to the reactant gases by virtue of the nanofabricated support structure. The combination of microchannel technology with nanofabricated catalysts provides a synergistic effect, enhancing both technologies with the potential to produce much more efficient systems than either technology alone. The development of highly efficient microchannel reactors will be applicable to multiple ISRU programs. By selection of proper nanofabricated catalysts, the microchannel reactors can be

  5. Nanofabrication with molds & stamps

    Directory of Open Access Journals (Sweden)

    Byron D. Gates

    2005-02-01

    Full Text Available A number of methods can be used to fabricate patterns with features having dimensions <100 nm. These techniques, however, can require specialized equipment and are often restricted to a cleanroom environment. Nanofabrication can be made accessible to multiple users by using elastomeric molds or stamps to transfer high-resolution patterns into other materials. These techniques are inexpensive and can transfer patterns into functional materials and onto a number of surfaces. This review describes recent advances in fabricating nanostructures using these techniques.

  6. Nanofabrication with Pulsed Lasers

    Directory of Open Access Journals (Sweden)

    Kabashin AV

    2010-01-01

    Full Text Available Abstract An overview of pulsed laser-assisted methods for nanofabrication, which are currently developed in our Institute (LP3, is presented. The methods compass a variety of possibilities for material nanostructuring offered by laser–matter interactions and imply either the nanostructuring of the laser-illuminated surface itself, as in cases of direct laser ablation or laser plasma-assisted treatment of semiconductors to form light-absorbing and light-emitting nano-architectures, as well as periodic nanoarrays, or laser-assisted production of nanoclusters and their controlled growth in gaseous or liquid medium to form nanostructured films or colloidal nanoparticles. Nanomaterials synthesized by laser-assisted methods have a variety of unique properties, not reproducible by any other route, and are of importance for photovoltaics, optoelectronics, biological sensing, imaging and therapeutics.

  7. Nanofabrication with pulsed lasers.

    Science.gov (United States)

    Kabashin, Av; Delaporte, Ph; Pereira, A; Grojo, D; Torres, R; Sarnet, Th; Sentis, M

    2010-02-24

    An overview of pulsed laser-assisted methods for nanofabrication, which are currently developed in our Institute (LP3), is presented. The methods compass a variety of possibilities for material nanostructuring offered by laser-matter interactions and imply either the nanostructuring of the laser-illuminated surface itself, as in cases of direct laser ablation or laser plasma-assisted treatment of semiconductors to form light-absorbing and light-emitting nano-architectures, as well as periodic nanoarrays, or laser-assisted production of nanoclusters and their controlled growth in gaseous or liquid medium to form nanostructured films or colloidal nanoparticles. Nanomaterials synthesized by laser-assisted methods have a variety of unique properties, not reproducible by any other route, and are of importance for photovoltaics, optoelectronics, biological sensing, imaging and therapeutics.

  8. Simulation study of a 3-D device integrating FinFET and UTBFET

    KAUST Repository

    Fahad, Hossain M.

    2015-01-01

    By integrating 3-D nonplanar fins and 2-D ultrathin bodies, wavy FinFETs merge two formerly competing technologies on a silicon-on-insulator platform to deliver enhanced transistor performance compared with conventional trigate FinFETs with unprecedented levels of chip-area efficiency. This makes it suitable for ultralarge-scale integration high-performance logic at and beyond the 10-nm technology node.

  9. Harnessing Disorder in Compression Based Nanofabrication

    Science.gov (United States)

    Engel, Clifford John

    The future of nanotechnologies depends on the successful development of versatile, low-cost techniques for patterning micro- and nanoarchitectures. While most approaches to nanofabrication have focused primarily on making periodic structures at ever smaller length scales with an ultimate goal of massively scaling their production, I have focused on introducing control into relatively disordered nanofabrication systems. Well-ordered patterns are increasingly unnecessary for a growing range of applications, from anti-biofouling coatings to light trapping to omniphobic surfaces. The ability to manipulate disorder, at will and over multiple length scales, starting with the nanoscale, can open new prospects for textured substrates and unconventional applications. Taking advantage of previously considered defects; I have been able to develop nanofabrication techniques with potential for massive scalability and the incorporation into a wide range of potential application. This thesis first describes the manipulation of the non-Newtonian properties of liquid Ga and Ga alloys to confine the metal and metal alloys in gratings with sub-wavelength periodicities. Through a solid to liquid phase change, I was able to access the superior plasmonic properties of liquid Ga for the generation of surface plasmon polaritons (SPP). The switching contract between solid and liquid Ga confine in the nanogratings allowed for reversible manipulation of SPP properties through heating and cooling around the relatively low melting temperature of Ga (29.8 °C). The remaining chapters focus on the development and characterization of an all polymer wrinkle material system. Wrinkles, spontaneous disordered features that are produced in response to compressive force, are an ideal for a growing number of applications where fine feature control is no longer the main motivation. However the mechanical limitations of many wrinkle systems have restricted the potential applications of wrinkled surfaces

  10. Design of modern nanofabrication facilities

    Science.gov (United States)

    Beswick, Sarah; Smith, Andrew; Morrish, Dru; Day, Daniel J.; Juodkazis, Saulius; Gu, Min

    2011-12-01

    We present a set of practical rules critical for designing and building a modern nanotechnology laboratory, focused on photonic applications in a cleanroom environment. We show the impacts on time, cost and quality of early design decisions and its importance on achieving the final fully functional laboratory. Best practice examples are presented for setting up a modern laboratory/facility, following analysis of the time, cost and quality constraints. The case study presented is the engineering and architectural solution of the nanofabrication cleanroom facility in the Advanced Technology Centre at Swinburne University of Technology, Australia. Set of practical rules is established for the cost and time efficient set up of the nanotechnology facilities for the research and development.

  11. A Novel Nanofabrication Technique of Silicon-Based Nanostructures

    Science.gov (United States)

    Meng, Lingkuan; He, Xiaobin; Gao, Jianfeng; Li, Junjie; Wei, Yayi; Yan, Jiang

    2016-11-01

    A novel nanofabrication technique which can produce highly controlled silicon-based nanostructures in wafer scale has been proposed using a simple amorphous silicon (α-Si) material as an etch mask. SiO2 nanostructures directly fabricated can serve as nanotemplates to transfer into the underlying substrates such as silicon, germanium, transistor gate, or other dielectric materials to form electrically functional nanostructures and devices. In this paper, two typical silicon-based nanostructures such as nanoline and nanofin have been successfully fabricated by this technique, demonstrating excellent etch performance. In addition, silicon nanostructures fabricated above can be further trimmed to less than 10 nm by combing with assisted post-treatment methods. The novel nanofabrication technique will be expected a new emerging technology with low process complexity and good compatibility with existing silicon integrated circuit and is an important step towards the easy fabrication of a wide variety of nanoelectronics, biosensors, and optoelectronic devices.

  12. Bio-Nanofabrication: Structuring Polymer Thin Films via Bacterial S-layer Proteins for Subsequent Use with Subtractive Nanofabrication Techniques

    Science.gov (United States)

    Esch, Mandy B.; Amponsah, Ebenezer K.; Bergkvist, Magnus

    2007-03-01

    Bio-molecule assisted lithography is a novel approach to create ordered patterns on the micro and nanometer size scale on thin films. The technique bears the potential to utilize self assembling properties of bio-molecules and to be integrated with conventional nanofabrication techniques. In the past, bacterial cell wall proteins (S-layers proteins) have been utilized to create ordered nanoparticle arrays. The work presented here employs S-layer proteins to shape UV-curable resist via an S-layer imprinted parylene template. Using this technique we can replicate S-layer patterns in resist thereby rendering the shape more resistant to subtractive nanofabrication techniques. The technique also demonstrates the adequacy of Nano Imprint Lithography to produce complex patterns not achievable with conventional lithography.

  13. Model for biological communication in a nanofabricated cell-mimic driven by stochastic resonance

    Energy Technology Data Exchange (ETDEWEB)

    Karig, David K [ORNL; Siuti, Piro [ORNL; Dar, Roy D. [University of Tennessee, Knoxville (UTK); Retterer, Scott T [ORNL; Doktycz, Mitchel John [ORNL; Simpson, Michael L [ORNL

    2011-01-01

    Cells offer natural examples of highly efficient networks of nanomachines. Accordingly, both intracellular and intercellular communication mechanisms in nature are looked to as a source of inspiration and instruction for engineered nanocommunication. Harnessing biological functionality in this manner requires an interdisciplinary approach that integrates systems biology, synthetic biology, and nanofabrication. Recent years have seen the amassing of a tremendous wealth of data from the sequencing of new organisms and from high throughput expression experiments. At the same time, a deeper fundamental understanding of individual cell function has been developed, as exemplified by the growth of fields such as noise biology, which seeks to characterize the role of noise in gene expression. The availability of well characterized biological components coupled with a deeper understanding of cell function has led to efforts to engineer both living cells and to create bio-like functionality in non-living substrates in the field of synthetic biology. Here, we present a model system that exemplifies the synergism between these realms of research. We propose a synthetic gene network for operation in a nanofabricated cell mimic array that propagates a biomolecular signal over long distances using the phenomenon of stochastic resonance. Our system consists of a bacterial quorum sensing signal molecule, a bistable genetic switch triggered by this signal, and an array of nanofabricated cell mimic wells that contain the genetic system. An optimal level of noise in the system helps to propagate a time-varying AHL signal over long distances through the array of mimics. This noise level is determined both by the system volume and by the parameters of the genetic network. Our proposed genetically driven stochastic resonance system serves as a testbed for exploring the potential harnessing of gene expression noise to aid in the transmission of a time-varying molecular signal.

  14. Energy Harvesting Using PVDF Piezoelectric Nanofabric

    Science.gov (United States)

    Shafii, Chakameh Shafii

    Energy harvesting using piezoelectric nanomaterial provides an opportunity for advancement towards self-powered electronics. The fabrication complexities and limited power output of these nano/micro generators have hindered these advancements thus far. This thesis presents a fabrication technique with electrospinning using a grounded cylinder as the collector. This method addresses the difficulties with the production and scalability of the nanogenerators. The non-aligned nanofibers are woven into a textile form onto the cylindrical drum that can be easily removed. The electrical poling and mechanical stretching induced by the electric field and the drum rotation increase the concentration of the piezoelectric beta phase in the PVDF nanofabric. The nanofabric is placed between two layers of polyethylene terephthalate (PET) that have interdigitated electrodes painted on them with silver paint. Applying continuous load onto the flexible PVDF nanofabric at 35Hz produces a peak voltage of 320 mV and maximum power of 2200 pW/(cm2) .

  15. Rational design and nanofabrication of gecko-inspired fibrillar adhesives.

    Science.gov (United States)

    Hu, Shihao; Xia, Zhenhai

    2012-08-20

    Gecko feet integrate many intriguing functions such as strong adhesion, easy detachment, and self-cleaning. Mimicking gecko toe pad structure leads to the development of new types of fibrillar adhesives useful for various applications. In this Concept article, in addition to the design of adhesive mimics by replicating gecko geometric features, we show a new trend of rational design by adding other physical, chemical, and biological principles on to the geometric merits, for enhancing robustness, responsive control, and durability. Current challenges and future directions are highlighted in the design and nanofabrication of biomimetic fibrillar adhesives.

  16. Nanoimprint lithography an enabling process for nanofabrication

    CERN Document Server

    Zhou, Weimin

    2013-01-01

    Nanoimprint Lithography: An enabling process for nanofabrication presents a comprehensive description of nanotechnology that is one of the most promising low-cost, high-throughput technologies for manufacturing nanostructures, and an emerging lithography candidates for 22, 16 and 11 nm nodes. It provides the exciting, multidisciplinary field, offering a wide range of topics covering: principles, process, material and application. This book would be of specific interest for researchers and graduate students in the field of nanoscience, nanotechnology and nanofabrication, material, physical, chemical, electric engineering and biology. Dr. Weimin Zhou is an associate professor at Shanghai Nanotechnology Promotion Center, China.

  17. Tip-Based Nanofabrication for Scalable Manufacturing

    Directory of Open Access Journals (Sweden)

    Huan Hu

    2017-03-01

    Full Text Available Tip-based nanofabrication (TBN is a family of emerging nanofabrication techniques that use a nanometer scale tip to fabricate nanostructures. In this review, we first introduce the history of the TBN and the technology development. We then briefly review various TBN techniques that use different physical or chemical mechanisms to fabricate features and discuss some of the state-of-the-art techniques. Subsequently, we focus on those TBN methods that have demonstrated potential to scale up the manufacturing throughput. Finally, we discuss several research directions that are essential for making TBN a scalable nano-manufacturing technology.

  18. Nanoskiving: A new method for nanofabrication

    Science.gov (United States)

    Xu, Qiaobing

    oxygen plasma generates free-standing metallic nanostructures. Chapter 1 is an overview of nanoskiving---a technique that combines thin-film deposition of metal on a topographically contoured substrate with sectioning using an ultramicrotome---as a method of fabricating nanostructures. Nanoskiving provides a simple and convenient procedure to produce arrays (over areas of mm2 to cm2) of structures with cross-sectional dimensions in the thirty-nanometer regime embedded in epoxy. The ability to control the dimensions of nanostructures, combined with the ability to manipulate and position them, enables the fabrication of nanostructures with geometries that are difficult to prepare by other methods. Two classes of applications--- in optics and in electronics---demonstrate the utility of nanostructures fabricated by nanoskiving. Chapter 2 shows the fabrication by nanoskiving of complex nanostructures that are difficult or impossible to achieve by other nanofabrication methods. These include multilayer structures, structures on curved surfaces, structures that span gaps, structures in less familiar materials, structures with high-aspect ratios, and large-area structures comprising two-dimensional periodic arrays. Chapter 3 demonstrates the Fabrication patterned arrays of gold structures (for example, rings) with wall thickness of 40 nm, and with high aspect ratios up to 25. Chapter 4 introduces the fabrication by nanoskiving of gold nanowires of uniform, controllable length, width, and height, and describes a systematic study of the dependence of the surface plasmon resonance on the geometry of these wires. Chapter 5 describes the fabrication of arrays of closed and open, loop-shaped nanostructures over mm2 area by nanoskiving. These arrays of metallic structures serve as frequency-selective surfaces at mid-infrared wavelengths. Chapter 6 describes a procedure to fabricate an array of nanoelectrodes that can be addressed from the back face of the slab of epoxy resin.

  19. Imaging and nanofabrication with the helium ion microscope of the Van Leeuwenhoek Laboratory in Delft.

    Science.gov (United States)

    Alkemade, Paul F A; Koster, Emma M; van Veldhoven, Emile; Maas, Diederik J

    2012-01-01

    Although helium ion microscopy (HIM) was introduced only a few years ago, many new application fields are emerging. The connecting factor between these novel applications is the unique interaction of the primary helium ion beam with the sample material at and just below its surface. In particular, the HIM secondary electron signal stems from an area that is extremely well localized around the point of incidence of the primary beam. This makes the HIM well suited for both high-resolution imaging and high-resolution nanofabrication. Another advantage in nanofabrication is the low ion backscattering fraction, which leads to a weak proximity effect. The subnanometer probe size and the unique beam-materials interactions have opened new areas of research. This review presents a selection of studies conducted on a single instrument. The selection encompasses applications ranging from imaging to nanofabrication and from fundamental academic research to applied industrial developments.

  20. Safety Profile of TiO2-Based Photocatalytic Nanofabrics for Indoor Formaldehyde Degradation

    Directory of Open Access Journals (Sweden)

    Guixin Cui

    2015-11-01

    Full Text Available Anatase TiO2 nanoparticles (TNPs are synthesized using the sol-gel method and loaded onto the surface of polyester-cotton (65/35 fabrics. The nanofabrics degrade formaldehyde at an efficiency of 77% in eight hours with visible light irradiation or 97% with UV light. The loaded TNPs display very little release from nanofabrics (~0.0% during a standard fastness to rubbing test. Assuming TNPs may fall off nanofabrics during their life cycles, we also examine the possible toxicity of TNPs to human cells. We found that up to a concentration of 220 μg/mL, they do not affect viability of human acute monocytic leukemia cell line THP-1 macrophages and human liver and kidney cells.

  1. Nanomaterials and nanofabrication for biomedical applications

    Science.gov (United States)

    Cheng, Chao-Min; Chia-Wen Wu, Kevin

    2013-08-01

    Traditional boundaries between materials science and engineering and life sciences are rapidly disintegrating as interdisciplinary research teams develop new materials-science-based tools for exploring fundamental issues in both medicine and biology. With recent technological advances in multiple research fields such as materials science, cell and molecular biology and micro-/nano-technology, much attention is shifting toward evaluating the functional advantages of nanomaterials and nanofabrication, at the cellular and molecular levels, for specific, biomedically relevant applications. The pursuit of this direction enhances the understanding of the mechanisms of, and therapeutic potentials for, some of the most lethal diseases, including cardiovascular diseases, organ fibrosis and cancers. This interdisciplinary approach has generated great interest among researchers working in a wide variety of communities including industry, universities and research laboratories. The purpose of this focus issue in Science and Technology of Advanced Materials is to bridge nanotechnology and biology with medicine, focusing more on the applications of nanomaterials and nanofabrication in biomedically relevant issues. This focus issue, we believe, will provide a more comprehensive understanding of (i) the preparation of nanomaterials and the underlying mechanisms of nanofabrication, and (ii) the linkage of nanomaterials and nanofabrication with biomedical applications. The multidisciplinary focus issue that we have attempted to organize is of interest to various research fields including biomaterials and tissue engineering, bioengineering, nanotechnology and nanomaterials, i.e. chemistry, physics and engineering. Nanomaterials and nanofabrication topics addressed in this focus issue include sensing and diagnosis (e.g. immunosensing and diagnostic devices for diseases), cellular and molecular biology (e.g. probing cellular behaviors and stem cell differentiation) and drug delivery

  2. Green chemistry and nanofabrication in a levitated Leidenfrost drop

    Science.gov (United States)

    Abdelaziz, Ramzy; Disci-Zayed, Duygu; Hedayati, Mehdi Keshavarz; Pöhls, Jan-Hendrik; Zillohu, Ahnaf Usman; Erkartal, Burak; Chakravadhanula, Venkata Sai Kiran; Duppel, Viola; Kienle, Lorenz; Elbahri, Mady

    2013-10-01

    Green nanotechnology focuses on the development of new and sustainable methods of creating nanoparticles, their localized assembly and integration into useful systems and devices in a cost-effective, simple and eco-friendly manner. Here we present our experimental findings on the use of the Leidenfrost drop as an overheated and charged green chemical reactor. Employing a droplet of aqueous solution on hot substrates, this method is capable of fabricating nanoparticles, creating nanoscale coatings on complex objects and designing porous metal in suspension and foam form, all in a levitated Leidenfrost drop. As examples of the potential applications of the Leidenfrost drop, fabrication of nanoporous black gold as a plasmonic wideband superabsorber, and synthesis of superhydrophilic and thermal resistive metal-polymer hybrid foams are demonstrated. We believe that the presented nanofabrication method may be a promising strategy towards the sustainable production of functional nanomaterials.

  3. Green chemistry and nanofabrication in a levitated Leidenfrost drop.

    Science.gov (United States)

    Abdelaziz, Ramzy; Disci-Zayed, Duygu; Hedayati, Mehdi Keshavarz; Pöhls, Jan-Hendrik; Zillohu, Ahnaf Usman; Erkartal, Burak; Chakravadhanula, Venkata Sai Kiran; Duppel, Viola; Kienle, Lorenz; Elbahri, Mady

    2013-01-01

    Green nanotechnology focuses on the development of new and sustainable methods of creating nanoparticles, their localized assembly and integration into useful systems and devices in a cost-effective, simple and eco-friendly manner. Here we present our experimental findings on the use of the Leidenfrost drop as an overheated and charged green chemical reactor. Employing a droplet of aqueous solution on hot substrates, this method is capable of fabricating nanoparticles, creating nanoscale coatings on complex objects and designing porous metal in suspension and foam form, all in a levitated Leidenfrost drop. As examples of the potential applications of the Leidenfrost drop, fabrication of nanoporous black gold as a plasmonic wideband superabsorber, and synthesis of superhydrophilic and thermal resistive metal-polymer hybrid foams are demonstrated. We believe that the presented nanofabrication method may be a promising strategy towards the sustainable production of functional nanomaterials.

  4. Applications of excimer laser in nanofabrication

    Energy Technology Data Exchange (ETDEWEB)

    Xia, Qiangfei; Chou, Stephen Y. [Princeton University, Nanostructure Laboratory, Department of Electrical Engineering, Princeton, NJ (United States)

    2010-01-15

    This paper addresses novel applications of an excimer laser (308 nm wavelength, 20 ns pulse duration) in nanofabrication. Specifically, laser assisted nanoimprint lithography (LAN), self-perfection by liquefaction (SPEL), fabrication of metal nanoparticle arrays, and the fabrication of sub-10-nm nanofluidic channels are covered. In LAN, a polymeric resist is melted by the laser pulse, and then imprinted with a fused silica mold within 200 ns. LAN has been demonstrated in patterning various polymer nanostructures on different substrates with high fidelity and uniformity, and negligible heat effect on both the mold and the substrate. SPEL is a novel technology that uses selective melting to remove fabrication defects in nanostructures post fabrication. Depending on the boundary conditions, SPEL is categorized into three basic types: Open-SPEL that takes place with surface open, Capped-SPEL where a cap plate holds the top surface of the nanostructures and Guided-SPEL where a plate held a distance above the structure guides the molten materials to rise and form a new structure with better profile. Using SPEL (in less than 200 ns), we have achieved a reduction of line edge roughness (LER) of Cr lines to 1.5 nm (3{sigma}) (560% improvement from the original), which is well below what the previous technologies permit, and a dramatic increase of the aspect ratio of a nanostructure. We have used SPEL to make sub-25-nm smooth cylindrical NIL pillar molds and smoothing Si waveguides. Excimer laser is also used to make metal nanoparticles. Monolayers of particles are fabricated on various substrates (silicon, fused silica and plastics) by exposing thin metal films to a single laser pulse. Periodic nanoparticle arrays have been fabricated by fragmentation of metal grating lines. The periodicity of these nanoparticles can be regulated by surface topography such as shallow trenches. Finally, an excimer laser pulse has been used to melt the top portion of 1D and 2D Si gratings to

  5. Femtosecond laser three-dimensional micro- and nanofabrication

    Energy Technology Data Exchange (ETDEWEB)

    Sugioka, Koji, E-mail: ksugioka@riken.jp [RIKEN Center for Advanced Photonics, Hirosawa 2-1, Wako, Saitama 351-0198 (Japan); Cheng, Ya, E-mail: ya.cheng@siom.ac.cn [Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, P.O. Box 800-211, Shanghai 201800 (China)

    2014-12-15

    The rapid development of the femtosecond laser has revolutionized materials processing due to its unique characteristics of ultrashort pulse width and extremely high peak intensity. The short pulse width suppresses the formation of a heat-affected zone, which is vital for ultrahigh precision fabrication, whereas the high peak intensity allows nonlinear interactions such as multiphoton absorption and tunneling ionization to be induced in transparent materials, which provides versatility in terms of the materials that can be processed. More interestingly, irradiation with tightly focused femtosecond laser pulses inside transparent materials makes three-dimensional (3D) micro- and nanofabrication available due to efficient confinement of the nonlinear interactions within the focal volume. Additive manufacturing (stereolithography) based on multiphoton absorption (two-photon polymerization) enables the fabrication of 3D polymer micro- and nanostructures for photonic devices, micro- and nanomachines, and microfluidic devices, and has applications for biomedical and tissue engineering. Subtractive manufacturing based on internal modification and fabrication can realize the direct fabrication of 3D microfluidics, micromechanics, microelectronics, and photonic microcomponents in glass. These microcomponents can be easily integrated in a single glass microchip by a simple procedure using a femtosecond laser to realize more functional microdevices, such as optofluidics and integrated photonic microdevices. The highly localized multiphoton absorption of a tightly focused femtosecond laser in glass can also induce strong absorption only at the interface of two closely stacked glass substrates. Consequently, glass bonding can be performed based on fusion welding with femtosecond laser irradiation, which provides the potential for applications in electronics, optics, microelectromechanical systems, medical devices, microfluidic devices, and small satellites. This review paper

  6. Femtosecond laser three-dimensional micro- and nanofabrication

    Science.gov (United States)

    Sugioka, Koji; Cheng, Ya

    2014-12-01

    The rapid development of the femtosecond laser has revolutionized materials processing due to its unique characteristics of ultrashort pulse width and extremely high peak intensity. The short pulse width suppresses the formation of a heat-affected zone, which is vital for ultrahigh precision fabrication, whereas the high peak intensity allows nonlinear interactions such as multiphoton absorption and tunneling ionization to be induced in transparent materials, which provides versatility in terms of the materials that can be processed. More interestingly, irradiation with tightly focused femtosecond laser pulses inside transparent materials makes three-dimensional (3D) micro- and nanofabrication available due to efficient confinement of the nonlinear interactions within the focal volume. Additive manufacturing (stereolithography) based on multiphoton absorption (two-photon polymerization) enables the fabrication of 3D polymer micro- and nanostructures for photonic devices, micro- and nanomachines, and microfluidic devices, and has applications for biomedical and tissue engineering. Subtractive manufacturing based on internal modification and fabrication can realize the direct fabrication of 3D microfluidics, micromechanics, microelectronics, and photonic microcomponents in glass. These microcomponents can be easily integrated in a single glass microchip by a simple procedure using a femtosecond laser to realize more functional microdevices, such as optofluidics and integrated photonic microdevices. The highly localized multiphoton absorption of a tightly focused femtosecond laser in glass can also induce strong absorption only at the interface of two closely stacked glass substrates. Consequently, glass bonding can be performed based on fusion welding with femtosecond laser irradiation, which provides the potential for applications in electronics, optics, microelectromechanical systems, medical devices, microfluidic devices, and small satellites. This review paper

  7. Nanofabrication by advanced electron microscopy using intense and focused beam∗

    Science.gov (United States)

    Furuya, Kazuo

    2008-01-01

    The nanogrowth and nanofabrication of solid substances using an intense and focused electron beam are reviewed in terms of the application of scanning and transmission electron microscopy (SEM, TEM and STEM) to control the size, position and structure of nanomaterials. The first example discussed is the growth of freestanding nanotrees on insulator substrates by TEM. The growth process of the nanotrees was observed in situ and analyzed by high-resolution TEM (HRTEM) and was mainly controlled by the intensity of the electron beam. The second example is position- and size-controlled nanofabrication by STEM using a focused electron beam. The diameters of the nanostructures grown ranged from 4 to 20 nm depending on the size of the electron beam. Magnetic nanostructures were also obtained using an iron-containing precursor gas, Fe(CO)5. The freestanding iron nanoantennas were examined by electron holography. The magnetic field was observed to leak from the nanostructure body which appeared to act as a ‘nanomagnet’. The third example described is the effect of a vacuum on the size and growth process of fabricated nanodots containing W in an ultrahigh-vacuum field-emission TEM (UHV-FE-TEM). The size of the dots can be controlled by changing the dose of electrons and the partial pressure of the precursor. The smallest particle size obtained was about 1.5 nm in diameter, which is the smallest size reported using this method. Finally, the importance of a smaller probe and a higher electron-beam current with atomic resolution is emphasized and an attempt to develop an ultrahigh-vacuum spherical aberration corrected STEM (Cs-corrected STEM) at NIMS is reported. PMID:27877936

  8. Microchannel Reactors for ISRU Applications Using Nanofabricated Catalysts Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Makel Engineering, Inc. (MEI) and USRA propose to develop microchannel reactors for In-Situ Resources Utilization (ISRU) using nanofabricated catalysts. The proposed...

  9. Precision Analysis of Three Dimension Free Curves Nanofabrication

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Three dimension free curves find wide applications in engineering. There is no problem to express them exactly mathematically, but th e reportage has not been done on the investigation of precision analysis of thre e-dimension free curves nanofabrication. Nanofabrication Precision includes the geometrical precision and the precision of driving system (below simply cal led the system precision). This paper submits the precision analysis method of c urve normal vector to analyze geometrical precision. ...

  10. Micro- and nano-fabricated implantable drug-delivery systems

    OpenAIRE

    Meng, Ellis; Hoang, Tuan

    2012-01-01

    Implantable drug-delivery systems provide new means for achieving therapeutic drug concentrations over entire treatment durations in order to optimize drug action. This article focuses on new drug administration modalities achieved using implantable drug-delivery systems that are enabled by micro- and nano-fabrication technologies, and microfluidics. Recent advances in drug administration technologies are discussed and remaining challenges are highlighted.

  11. Dispersion engineering for integrated nanophotonics

    CERN Document Server

    Vanbésien, Olivier

    2014-01-01

    This book shows how dispersion engineering in two dimensional dielectric photonic crystals can provide new effects for the precise control of light propagation for integrated nanophotonics.Dispersion engineering in regular and graded photonic crystals to promote anomalous refraction effects is studied from the concepts to experimental demonstration via nanofabrication considerations. Self collimation, ultra and negative refraction, second harmonic generation, mirage and invisibility effects which lead to an unprecedented control of light propagation at the (sub-)wavelength scale for the

  12. Graphene and Other 2D Material Components Dynamic Characterization and Nanofabrication at Atomic Scale

    Directory of Open Access Journals (Sweden)

    Wei Wang

    2015-01-01

    Full Text Available We demonstrate how abreaction corrected transmission electron microscopy (TEM analysis techniques that are commonly used in nanostructure characterization can be used to study the morphology of graphene and other 2D materials at atomic scale, even subangstrom scale, and evolution of nanostructure and from which we determine the graphene components nanofabrication process. The key contributions of this work are perhaps focused on two areas: (1 recent progress on graphene characterization from the TEM aspect and (2 how the electron beam can be used to fabricate nanoribbon from graphene or similar 2D material.

  13. Friction-induced nanofabrication method to produce protrusive nanostructures on quartz

    Science.gov (United States)

    Song, Chenfei; Li, Xiaoying; Yu, Bingjun; Dong, Hanshan; Qian, Linmao; Zhou, Zhongrong

    2011-12-01

    In this paper, a new friction-induced nanofabrication method is presented to fabricate protrusive nanostructures on quartz surfaces through scratching a diamond tip under given normal loads. The nanostructures, such as nanodots, nanolines, surface mesas and nanowords, can be produced on the target surface by programming the tip traces according to the demanded patterns. The height of these nanostructures increases with the increase of the number of scratching cycles or the normal load. Transmission electron microscope observations indicated that the lattice distortion and dislocations induced by the mechanical interaction may have played a dominating role in the formation of the protrusive nanostructures on quartz surfaces. Further analysis reveals that during scratching, a contact pressure ranged from 0.4 P y to P y ( P y is the critical yield pressure of quartz) is apt to produce protuberant nanostructures on quartz under the given experimental conditions. Finally, it is of great interest to find that the protrusive nanostructures can be selectively dissolved in 20% KOH solution. Since the nanowords can be easily 'written' by friction-induced fabrication and 'erased' through selective etching on a quartz surface, this friction-induced method opens up new opportunities for future nanofabrication.

  14. Friction-induced nanofabrication method to produce protrusive nanostructures on quartz

    Directory of Open Access Journals (Sweden)

    Li Xiaoying

    2011-01-01

    Full Text Available Abstract In this paper, a new friction-induced nanofabrication method is presented to fabricate protrusive nanostructures on quartz surfaces through scratching a diamond tip under given normal loads. The nanostructures, such as nanodots, nanolines, surface mesas and nanowords, can be produced on the target surface by programming the tip traces according to the demanded patterns. The height of these nanostructures increases with the increase of the number of scratching cycles or the normal load. Transmission electron microscope observations indicated that the lattice distortion and dislocations induced by the mechanical interaction may have played a dominating role in the formation of the protrusive nanostructures on quartz surfaces. Further analysis reveals that during scratching, a contact pressure ranged from 0.4Py to Py (Py is the critical yield pressure of quartz is apt to produce protuberant nanostructures on quartz under the given experimental conditions. Finally, it is of great interest to find that the protrusive nanostructures can be selectively dissolved in 20% KOH solution. Since the nanowords can be easily 'written' by friction-induced fabrication and 'erased' through selective etching on a quartz surface, this friction-induced method opens up new opportunities for future nanofabrication.

  15. Laser manipulation of atoms and nanofabrication

    NARCIS (Netherlands)

    Jurdík, Erich

    2001-01-01

    Fundamental interaction processes between atoms and photons are exploited to control external degrees of freedom of the atoms. Laser light, when properly tuned near an atomic resonance, exerts such forces that the atoms are repelled from or attracted to the regions with low light intensities. We use

  16. Nano-fabricated plasmonic optical transformer

    Science.gov (United States)

    Choo, Hyuck; Cabrini, Stefano; Schuck, P. James; Liang, Xiaogan; Yablonovitch, Eli

    2015-06-09

    The present invention provides a plasmonic optical transformer to produce a highly focuses optical beam spot, where the transformer includes a first metal layer, a dielectric layer formed on the first metal layer, and a second metal layer formed on the dielectric layer, where the first metal layer, the dielectric layer, and the second layer are patterned to a shape including a first section having a first cross section, a second section following the first section having a cross-section tapering from the first section to a smaller cross-section, and a third section following the second section having a cross-section matching the tapered smaller cross-section of the second section.

  17. NANOFILM - New metallic nanocomposites for micro and nanofabrication

    DEFF Research Database (Denmark)

    Fischer, Søren Vang

    or catalysts. The possibility to effectively structure the nanocomposites are however a limiting factor. In this project the UV sensitive photoresist SU-8 gold and silver nanocomposites have been fabricated which can be deposited and structured using standard micro and nanofabrication processes...... with the ex situ method. An in situ method was then tried for the development of both gold and silver SU-8 nanocomposites. In this procedure, the metal precursors were incorporated with SU-8 and the respective nanoparticles formed within the photoresist matrix. The nanoparticles should preferably be formed....... A technique called pre grafting was found to be most effective for the stabilisation process. In pre grafting the nanoparticles were formed in the presence of PVP-VA. For the two metal nanocomposites attempted to be fabricated only the gold SU-8 nanocomposite was successfully and reproducibly produced...

  18. Scalable nanofabrication of U-shaped nanowire resonators with tunable optical magnetism.

    Science.gov (United States)

    Zhou, Fan; Wang, Chen; Dong, Biqin; Chen, Xiangfan; Zhang, Zhen; Sun, Cheng

    2016-03-21

    Split ring resonators have been studied extensively in reconstituting the diminishing magnetism at high electromagnetic frequencies in nature. However, breakdown in the linear scaling of artificial magnetism is found to occur at the near-infrared frequency mainly due to the increasing contribution of self-inductance while reducing dimensions of the resonators. Although alternative designs have enabled artificial magnetism at optical frequencies, their sophisticated configurations and fabrication procedures do not lend themselves to easy implementation. Here, we report scalable nanofabrication of U-shaped nanowire resonators (UNWRs) using the high-throughput nanotransfer printing method. By providing ample area for conducting oscillating electric current, UNWRs overcome the saturation of the geometric scaling of the artificial magnetism. We experimentally demonstrated coarse and fine tuning of LC resonances over a wide wavelength range from 748 nm to 1600 nm. The added flexibility in transferring to other substrates makes UNWR a versatile building block for creating functional metamaterials in three dimensions.

  19. Nanocharacterization and nanofabrication of a Nafion thin film in liquids by atomic force microscopy.

    Science.gov (United States)

    Umemura, Kazuo; Wang, Tong; Hara, Masahiko; Kuroda, Reiko; Uchida, On; Nagai, Masayuki

    2006-03-28

    We demonstrated the nanocharacterization and nanofabrication of a Nafion thin film using atomic force microscopy (AFM). AFM images showed that the Nafion molecules form nanoclusters in water, in 5% methanol, and in acetic acid. Young's modulus E of a Nafion film was estimated by sequential force curve measurements in water and in 5% methanol on one sample surface. Ewater/E5% methanol was 1.75 +/- 0.40, so the film was much softer in 5% methanol than in water. Even when solvent was replaced from 5% methanol to water, Young's modulus was not recovered soon. We showed the first example of the mechanical properties of a Nafion film on the nanoscale. Furthermore, we succeeded in fabricating 3D nanostructures on a Nafion surface by AFM nanolithography in liquids. Our results showed the new potential of the AFM nanolithography of a polymer film by softening the molecules in liquids.

  20. Fermionic Correlators from Integrability

    CERN Document Server

    Caetano, Joao

    2016-01-01

    We study three-point functions of single-trace operators in the su(1|1) sector of planar N = 4 SYM borrowing several tools based on Integrability. In the most general configuration of operators in this sector, we have found a determinant expression for the tree-level structure constants. We then compare the predictions of the recently proposed hexagon program against all available data. We have obtained a match once additional sign factors are included when the two hexagon form-factors are assembled together to form the structure constants. In the particular case of one BPS and two non-BPS operators we managed to identify the relevant form-factors with a domain wall partition function of a certain six-vertex model. This partition function can be explicitly evaluated and factorizes at all loops. In addition, we use this result to compute the structure constants and show that at strong coupling in the so-called BMN regime, its leading order contribution has a determinant expression.

  1. Fermionic correlators from integrability

    Science.gov (United States)

    Caetano, João; Fleury, Thiago

    2016-09-01

    We study three-point functions of single-trace operators in the {s}{u}(1Big|1) sector of planar {N}=4 SYM borrowing several tools based on Integrability. In the most general configuration of operators in this sector, we have found a determinant expression for the tree-level structure constants. We then compare the predictions of the recently proposed hexagon program against all available data. We have obtained a match once additional sign factors are included when the two hexagon form-factors are assembled together to form the structure constants. In the particular case of one BPS and two non-BPS operators we managed to identify the relevant form-factors with a domain wall partition function of a certain six-vertex model. This partition function can be explicitly evaluated and factorizes at all loops. In addition, we use this result to compute the structure constants and show that at strong coupling in the so-called BMN regime, its leading order contribution has a determinant expression.

  2. Nondestructive tribochemistry-assisted nanofabrication on GaAs surface

    Science.gov (United States)

    Song, Chenfei; Li, Xiaoying; Dong, Hanshan; Yu, Bingjun; Wang, Zhiming; Qian, Linmao

    2015-03-01

    A tribochemistry-assisted method has been developed for nondestructive surface nanofabrication on GaAs. Without any applied electric field and post etching, hollow nanostructures can be directly fabricated on GaAs surfaces by sliding a SiO2 microsphere under an ultralow contact pressure in humid air. TEM observation on the cross-section of the fabricated area shows that there is no appreciable plastic deformation under a 4 nm groove, confirming that GaAs can be removed without destruction. Further analysis suggests that the fabrication relies on the tribochemistry with the participation of vapor in humid air. It is proposed that the formation and breakage of GaAs-O-Si bonding bridges are responsible for the removal of GaAs material during the sliding process. As a nondestructive and conductivity-independent method, it will open up new opportunities to fabricate defect-free and well-ordered nucleation positions for quantum dots on GaAs surfaces.

  3. Relationship between Length and Surface-Enhanced Raman Spectroscopy Signal Strength in Metal Nanoparticle Chains: Ideal Models versus Nanofabrication

    Directory of Open Access Journals (Sweden)

    Kristen D. Alexander

    2012-01-01

    Full Text Available We have employed capillary force deposition on ion beam patterned substrates to fabricate chains of 60 nm gold nanospheres ranging in length from 1 to 9 nanoparticles. Measurements of the surface-averaged SERS enhancement factor strength for these chains were then compared to the numerical predictions. The SERS enhancement conformed to theoretical predictions in the case of only a few chains, with the vast majority of chains tested not matching such behavior. Although all of the nanoparticle chains appear identical under electron microscope observation, the extreme sensitivity of the SERS enhancement to nanoscale morphology renders current nanofabrication methods insufficient for consistent production of coupled nanoparticle chains. Notwithstanding this fact, the aggregate data also confirmed that nanoparticle dimers offer a large improvement over the monomer enhancement while conclusively showing that, within the limitations imposed by current state-of-the-art nanofabrication techniques, chains comprising more than two nanoparticles provide only a marginal signal boost over the already considerable dimer enhancement.

  4. Nuclear astrophysics lessons from INTEGRAL.

    Science.gov (United States)

    Diehl, Roland

    2013-02-01

    Measurements of high-energy photons from cosmic sources of nuclear radiation through ESA's INTEGRAL mission have advanced our knowledge: new data with high spectral resolution showed that characteristic gamma-ray lines from radioactive decays occur throughout the Galaxy in its interstellar medium. Although the number of detected sources and often the significance of the astrophysical results remain modest, conclusions derived from this unique astronomical window of radiation originating from nuclear processes are important, complementing the widely-employed atomic-line based spectroscopy. We review the results and insights obtained in the past decade from gamma-ray line measurements of cosmic sources in the context of their astrophysical questions.

  5. Electron beam deposition for nanofabrication : Insights from surface science

    NARCIS (Netherlands)

    Wnuk, J. D.; Rosenberg, S. G.; Gorham, J. M.; van Dorp, W. F.; Hagen, C. W.; Fairbrother, D. H.

    2011-01-01

    Electron beam induced deposition (EBID) is a direct-write lithographic technique that utilizes the dissociation of volatile precursors by a focused electron beam in a low vacuum environment to create nanostructures. Notable advantages of EBID over competing lithographic techniques are that it is a s

  6. Nanofabrication of planar split ring resonators for negative refractive index metamaterials in the infrared range

    Directory of Open Access Journals (Sweden)

    ZORAN JAKSIC

    2006-06-01

    Full Text Available Experimental nanofabrication of planar structures for one-dimensional metamaterials designed to achieve a negative effective refractive index in the mid-infrared range (5–10 micrometers was performed. Double split ring and complementary double split ring resonators (SRR and CSRR with square and circular geometries, were chosen to be fabricated since these are the basic building blocks to achieve a negative effective dielectric permittivity and magnetic permeability. Scanning probe nanolithography with z-scanner movement was used to fabricate straight-line and curvilinear segments with a line width of 80 – 120 nm. The geometries were delineated in 20 nm thin silver layers sputter-deposited on a positive photoresist substrate spin-coated on polished single crystal silicon wafers, as well as on polycarbonate slabs. The morphology of the structures was characterized by atomic force microscopy. The feature repeatibility was 60 – 150 nm, depending on the process conditions and the feature complexity. The nanolithographic groove depth in different samples ranged from 4 nm to 80 nm.

  7. Nanofabrication and coloration study of artificial Morpho butterfly wings with aligned lamellae layers.

    Science.gov (United States)

    Zhang, Sichao; Chen, Yifang

    2015-11-18

    The bright and iridescent blue color from Morpho butterfly wings has attracted worldwide attentions to explore its mysterious nature for long time. Although the physics of structural color by the nanophotonic structures built on the wing scales has been well established, replications of the wing structure by standard top-down lithography still remains a challenge. This paper reports a technical breakthrough to mimic the blue color of Morpho butterfly wings, by developing a novel nanofabrication process, based on electron beam lithography combined with alternate PMMA/LOR development/dissolution, for photonic structures with aligned lamellae multilayers in colorless polymers. The relationship between the coloration and geometric dimensions as well as shapes is systematically analyzed by solving Maxwell's Equations with a finite domain time difference simulator. Careful characterization of the mimicked blue by spectral measurements under both normal and oblique angles are carried out. Structural color in blue reflected by the fabricated wing scales, is demonstrated and further extended to green as an application exercise of the new technique. The effects of the regularity in the replicas on coloration are analyzed. In principle, this approach establishes a starting point for mimicking structural colors beyond the blue in Morpho butterfly wings.

  8. Top-Down Nanofabrication and Characterization of 20 nm Silicon Nanowires for Biosensing Applications.

    Science.gov (United States)

    M Nuzaihan, M N; Hashim, U; Md Arshad, M K; Rahim Ruslinda, A; Rahman, S F A; Fathil, M F M; Ismail, Mohd H

    2016-01-01

    A top-down nanofabrication approach is used to develop silicon nanowires from silicon-on-insulator (SOI) wafers and involves direct-write electron beam lithography (EBL), inductively coupled plasma-reactive ion etching (ICP-RIE) and a size reduction process. To achieve nanometer scale size, the crucial factors contributing to the EBL and size reduction processes are highlighted. The resulting silicon nanowires, which are 20 nm in width and 30 nm in height (with a triangular shape) and have a straight structure over the length of 400 μm, are fabricated precisely at the designed location on the device. The device is applied in biomolecule detection based on the changes in drain current (Ids), electrical resistance and conductance of the silicon nanowires upon hybridization to complementary target deoxyribonucleic acid (DNA). In this context, the scaled-down device exhibited superior performances in terms of good specificity and high sensitivity, with a limit of detection (LOD) of 10 fM, enables for efficient label-free, direct and higher-accuracy DNA molecules detection. Thus, this silicon nanowire can be used as an improved transducer and serves as novel biosensor for future biomedical diagnostic applications.

  9. Nanofabrication and coloration study of artificial Morpho butterfly wings with aligned lamellae layers

    Science.gov (United States)

    Zhang, Sichao; Chen, Yifang

    2015-11-01

    The bright and iridescent blue color from Morpho butterfly wings has attracted worldwide attentions to explore its mysterious nature for long time. Although the physics of structural color by the nanophotonic structures built on the wing scales has been well established, replications of the wing structure by standard top-down lithography still remains a challenge. This paper reports a technical breakthrough to mimic the blue color of Morpho butterfly wings, by developing a novel nanofabrication process, based on electron beam lithography combined with alternate PMMA/LOR development/dissolution, for photonic structures with aligned lamellae multilayers in colorless polymers. The relationship between the coloration and geometric dimensions as well as shapes is systematically analyzed by solving Maxwell’s Equations with a finite domain time difference simulator. Careful characterization of the mimicked blue by spectral measurements under both normal and oblique angles are carried out. Structural color in blue reflected by the fabricated wing scales, is demonstrated and further extended to green as an application exercise of the new technique. The effects of the regularity in the replicas on coloration are analyzed. In principle, this approach establishes a starting point for mimicking structural colors beyond the blue in Morpho butterfly wings.

  10. Parallel computation with molecular-motor-propelled agents in nanofabricated networks.

    Science.gov (United States)

    Nicolau, Dan V; Lard, Mercy; Korten, Till; van Delft, Falco C M J M; Persson, Malin; Bengtsson, Elina; Månsson, Alf; Diez, Stefan; Linke, Heiner; Nicolau, Dan V

    2016-03-01

    The combinatorial nature of many important mathematical problems, including nondeterministic-polynomial-time (NP)-complete problems, places a severe limitation on the problem size that can be solved with conventional, sequentially operating electronic computers. There have been significant efforts in conceiving parallel-computation approaches in the past, for example: DNA computation, quantum computation, and microfluidics-based computation. However, these approaches have not proven, so far, to be scalable and practical from a fabrication and operational perspective. Here, we report the foundations of an alternative parallel-computation system in which a given combinatorial problem is encoded into a graphical, modular network that is embedded in a nanofabricated planar device. Exploring the network in a parallel fashion using a large number of independent, molecular-motor-propelled agents then solves the mathematical problem. This approach uses orders of magnitude less energy than conventional computers, thus addressing issues related to power consumption and heat dissipation. We provide a proof-of-concept demonstration of such a device by solving, in a parallel fashion, the small instance {2, 5, 9} of the subset sum problem, which is a benchmark NP-complete problem. Finally, we discuss the technical advances necessary to make our system scalable with presently available technology.

  11. MEMS-enabled Dip Pen Nanolithography for directed nanoscale deposition and high-throughput nanofabrication

    Science.gov (United States)

    Haaheim, J. R.; Nafday, O. A.; Levesque, T.; Fragala, J.; Shile, R.

    2009-02-01

    Precision nanoscale deposition is a fundamental requirement for nanoscience research, development, and commercial implementation. Dip Pen Nanolithography(R) (DPN) is an inherently additive SPM-based technique which operates under ambient conditions, making it suitable to deposit a wide range of biological and inorganic materials. This technique is fundamentally enabled by a portfolio of MEMS devices tailored for microfluidic ink delivery, directed placement of nanoscale materials via actuated cantilevers, and cm2 tip arrays for high-throughput nanofabrication. Multiplexed deposition of nanoscale materials is a challenging problem, but we have implemented InkWells(TM) to enable selective delivery of ink materials to different tips in multiple probe arrays, while preventing cross-contamination. Active Pens(TM) can take advantage of this, directly place a variety of materials in nanoscale proximity, and do so in a "clean" fashion since the cantilevers can be manipulated in Z. Further, massively parallel two-dimensional nanopatterning with DPN is now commercially available via NanoInk's 2D nano PrintArray(TM), making DPN a highthroughput, flexible and versatile method for precision nanoscale pattern formation. By fabricating 55,000 tip-cantilevers across a 1 cm2 chip, we leverage the inherent versatility of DPN and demonstrate large area surface coverage, routinely achieving throughputs of 3×107 μm2 per hour. Further, we have engineered the device to be easy to use, wire-free, and fully integrated with the NSCRIPTOR's scanner, stage, and sophisticated lithography routines. In this talk we discuss the methods of operating this commercially available device, and subsequent results showing sub-100 nm feature sizes and excellent uniformity (standard deviation portfolio including: 1) rapidly and flexibly generating nanostructures; 2) chemically directed assembly and 3) directly writing biological materials.

  12. From PACS to integrated EMR.

    Science.gov (United States)

    Ratib, Osman; Swiernik, Michael; McCoy, J Michael

    2003-01-01

    open systems which allows easier and more functional integration of medical data from different sources. Furthermore, the emergence of a new strategy for software development, based on open source components, allows software programs to be shared and exchanged between different institutions leading to more rapid deployment of standardized electronic patient record.

  13. STUDY OF UREMIC TOXIN FLUXES ACROSS NANOFABRICATED HEMODIALYSIS MEMBRANES USING IRREVERSIBLE THERMODYNAMICS

    Directory of Open Access Journals (Sweden)

    Assem Hedayat

    2013-03-01

    Conclusions: Nanofabricated hemodialysis membranes with a reduced thickness and an applied electric potential can enhance the effective diffusivity and electro-migration flux of the respective uremic toxins by 3 orders of magnitude as compared to those passing through the high flux hemodialyzer.

  14. Lessons learnt from INTEGRAL AGN

    CERN Document Server

    Beckmann, V; Soldi, S; Alfonso-Garzon, J; Courvoisier, T J -L; Domingo, A; Gehrels, N; Lubinski, P; Mas-Hesse, J M; Zdziarski, A A

    2010-01-01

    The INTEGRAL mission provides a large data set for studying the hard X-ray properties of AGN and allows to test the unified scheme for AGN. We present results based on the analysis of 199 AGN. A difference between the Seyfert types is detected in slightly flatter spectra with higher cut-off energies and lower luminosities for the more absorbed/type 2 AGN. When applying a Compton reflection model, the underlying continua (photon index 1.95) appear the same in Seyfert 1 and 2, and the reflection strength is R=1 in both cases, with differences in the inclination angle only. A difference is seen in the sense that Seyfert 1 are on average twice as luminous in hard X-rays than the Seyfert 2 galaxies. The unified model for Seyfert galaxies seems to hold, showing in hard X-rays that the central engine is the same in Seyfert 1 and 2 galaxies, seen under different inclination angle and absorption. Based on our knowledge of AGN from INTEGRAL data, we briefly outline open questions and investigations to answer them. In t...

  15. Monolithic optofluidic ring resonator lasers created by femtosecond laser nanofabrication.

    Science.gov (United States)

    Chandrahalim, Hengky; Chen, Qiushu; Said, Ali A; Dugan, Mark; Fan, Xudong

    2015-05-21

    We designed, fabricated, and characterized a monolithically integrated optofluidic ring resonator laser that is mechanically, thermally, and chemically robust. The entire device, including the ring resonator channel and sample delivery microfluidics, was created in a block of fused-silica glass using a 3-dimensional femtosecond laser writing process. The gain medium, composed of Rhodamine 6G (R6G) dissolved in quinoline, was flowed through the ring resonator. Lasing was achieved at a pump threshold of approximately 15 μJ mm(-2). Detailed analysis shows that the Q-factor of the optofluidic ring resonator is 3.3 × 10(4), which is limited by both solvent absorption and scattering loss. In particular, a Q-factor resulting from the scattering loss can be as high as 4.2 × 10(4), suggesting the feasibility of using a femtosecond laser to create high quality optical cavities.

  16. Soft X-Ray (1-7 nm) Solar Spectrometer based on novel Nanowriter Electron-Beam Nanofabrication Technology

    Science.gov (United States)

    Didkovsky, L. V.; Wieman, S. R.; Chao, W.

    2015-12-01

    A new soft X-ray (SXR) spectrometer combines proven detector technology demonstrated on the SOHO Solar EUV Monitor (SOHO/SEM) and SDO EUV SpectroPhotometer (SDO/EVE/ESP) instruments with novel technology for X-ray optics nanofabrication developed at the Lawrence Berkeley National Laboratory. The new spectrometer will provide solar SXR measurements of absolute irradiance in the 1.0 to 7.0 nm range spectrally resolved into bands narrower than 1 nm - measurements that are not available from existing solar-observing instruments but are important for studying and modeling coronal dynamics and the Sun-Earth's connection, e.g. the Earth's Ionosphere. For the proposed SXR spectrometer we will introduce a transmission grating based on novel Nanowriter Electron-Beam Nanofabrication technology developed at the Center for X-ray Optics (CXRO) at the Lawrence Berkeley National Laboratory. The CXRO technology has been used in the fabrication of X-ray zone plates with feature sizes as small as 25 nm in optical elements with overall sizes on the order of 1 cm. The CXRO technology has significant flexibility in terms of pattern geometry, and is thus capable of producing linear transmission gratings with aperture sizes similar to SEM and ESP but with four times the dispersion. With such dispersion, reasonable spectral resolution (< 1nm) can be obtained using commercial off-the shelf (COTS) X-ray sensitive AXUV type silicon photodiodes from the Optodiode Corp. in an instrument with overall size and mass similar to that of SEM or ESP.

  17. From integrable to conformal theory

    Energy Technology Data Exchange (ETDEWEB)

    Babelon, O. (Paris-6 Univ., 75 (France). Lab. de Physique Theorique et Hautes Energies)

    1990-12-01

    Working in the context of Toda field theory, we establish the relationship between their integrability properties and their conformal structure, thereby clarifying the role of the Yang-Baxter equation in conformal field theory. (orig.).

  18. From integrative bioethics to pseudoscience.

    Science.gov (United States)

    Bracanović, Tomislav

    2012-12-01

    Integrative bioethics is a brand of bioethics conceived and propagated by a group of Croatian philosophers and other scholars. This article discusses and shows that the approach encounters several serious difficulties. In criticizing certain standard views on bioethics and in presenting their own, the advocates of integrative bioethics fall into various conceptual confusions and inconsistencies. Although presented as a project that promises to deal with moral dilemmas created by modern science and technology, integrative bioethics does not contain the slightest normativity or action-guiding capacity. Portrayed as a scientific and interdisciplinary enterprise, integrative bioethics displays a large number of pseudoscientific features that throw into doubt its overall credibility. © 2012 Blackwell Publishing Ltd.

  19. A beam flexure-based nanopositioning stage supporting laser direct-write nanofabrication

    Science.gov (United States)

    Zhang, Zhen; Wang, Peng; Yan, Peng; Guan, YingChun

    2016-08-01

    A nanopositioning system of both millimetric stroke and nanometric tracking accuracy is a key component for nanofabrication in many applications. In this paper, a novel bi-axial beam-flexure nano servo stage is proposed to support a direct writing system for femtosecond laser nanofabrication. The important features of the stage lie in: a mirror symmetric instead of rotational symmetric configuration is adopted to restrict cross axis coupling, and a novel Z-shaped guidance module is proposed to achieve relative large linear stiffness range, in addition a redundant constraints module is introduced to increase off-axis stiffness of the stage. Mechanical analysis and system identification are provided, with which a feedback control algorithm demonstrates the tracking capability for laser fabrication purposes. Based on the fabricated XY nano-stage, real time control and measurements are deployed, demonstrating the millimetric operating workspace and 77.8 nm (RMS) error of tracking a circular trajectory.

  20. Transdisciplinary knowledge integration : cases from integrated assessment and vulnerability assessment

    NARCIS (Netherlands)

    Hinkel, J.

    2008-01-01

    Keywords: climate change, integrated assessment, knowledge integration, transdisciplinary research, vulnerability, vulnerability assessment. This thesis explores how transdisciplinary knowledge integration can be facilitated in the context of integrated assessments and vulnerability assessments of

  1. Measuring Integrated Information from the Decoding Perspective.

    Directory of Open Access Journals (Sweden)

    Masafumi Oizumi

    2016-01-01

    Full Text Available Accumulating evidence indicates that the capacity to integrate information in the brain is a prerequisite for consciousness. Integrated Information Theory (IIT of consciousness provides a mathematical approach to quantifying the information integrated in a system, called integrated information, Φ. Integrated information is defined theoretically as the amount of information a system generates as a whole, above and beyond the amount of information its parts independently generate. IIT predicts that the amount of integrated information in the brain should reflect levels of consciousness. Empirical evaluation of this theory requires computing integrated information from neural data acquired from experiments, although difficulties with using the original measure Φ precludes such computations. Although some practical measures have been previously proposed, we found that these measures fail to satisfy the theoretical requirements as a measure of integrated information. Measures of integrated information should satisfy the lower and upper bounds as follows: The lower bound of integrated information should be 0 and is equal to 0 when the system does not generate information (no information or when the system comprises independent parts (no integration. The upper bound of integrated information is the amount of information generated by the whole system. Here we derive the novel practical measure Φ* by introducing a concept of mismatched decoding developed from information theory. We show that Φ* is properly bounded from below and above, as required, as a measure of integrated information. We derive the analytical expression of Φ* under the Gaussian assumption, which makes it readily applicable to experimental data. Our novel measure Φ* can generally be used as a measure of integrated information in research on consciousness, and also as a tool for network analysis on diverse areas of biology.

  2. Measuring Integrated Information from the Decoding Perspective.

    Science.gov (United States)

    Oizumi, Masafumi; Amari, Shun-ichi; Yanagawa, Toru; Fujii, Naotaka; Tsuchiya, Naotsugu

    2016-01-01

    Accumulating evidence indicates that the capacity to integrate information in the brain is a prerequisite for consciousness. Integrated Information Theory (IIT) of consciousness provides a mathematical approach to quantifying the information integrated in a system, called integrated information, Φ. Integrated information is defined theoretically as the amount of information a system generates as a whole, above and beyond the amount of information its parts independently generate. IIT predicts that the amount of integrated information in the brain should reflect levels of consciousness. Empirical evaluation of this theory requires computing integrated information from neural data acquired from experiments, although difficulties with using the original measure Φ precludes such computations. Although some practical measures have been previously proposed, we found that these measures fail to satisfy the theoretical requirements as a measure of integrated information. Measures of integrated information should satisfy the lower and upper bounds as follows: The lower bound of integrated information should be 0 and is equal to 0 when the system does not generate information (no information) or when the system comprises independent parts (no integration). The upper bound of integrated information is the amount of information generated by the whole system. Here we derive the novel practical measure Φ* by introducing a concept of mismatched decoding developed from information theory. We show that Φ* is properly bounded from below and above, as required, as a measure of integrated information. We derive the analytical expression of Φ* under the Gaussian assumption, which makes it readily applicable to experimental data. Our novel measure Φ* can generally be used as a measure of integrated information in research on consciousness, and also as a tool for network analysis on diverse areas of biology.

  3. Electrospun assembly: a nondestructive nanofabrication for transparent photosensors

    Science.gov (United States)

    Wang, Yuting; Shahid, Muhammad; Cheng, Jing; Nishijima, Hiroki; Pan, Wei

    2017-04-01

    Transparent electrodes based on a metal nanotrough network show superior electrical and optical properties. However, most metal networks fabricated by electrospinning are formed as film electrodes and are hard to pattern for the geometry shape of the device without any loss. Herein, we fabricate a highly transparent and flexible photodetector (PD) via a simple controlled electrospinning method. Owing to the trough- and belt-like geometry of Pt network electrodes, up to 83% transmittance can be obtained when the sheet resistances is 16 Ω sq‑1, which may be the best performance for Pt-based transparent electrodes at present. The benefit of this advantage, is that a wearable UV PD could be obtained by a facile electrospun assembly. This all-transparent device achieves an extraordinary transparency of 90% at 550 nm and an even superior response sensitivity compared with that of a Pt film-based sensor (14 Ω sq‑1 at 50% transparency). More importantly, this assembly approach has the versatility to enable us to fabricate highly transparent and flexible electronics in wearable applications, especially for the integration of oxide semiconductors and adhesive photoelectric hybrids.

  4. Nanofabrication of Nonfouling Surfaces for Micropatterning of Cell and Microtissue

    Directory of Open Access Journals (Sweden)

    Hidenori Otsuka

    2010-08-01

    Full Text Available Surface engineering techniques for cellular micropatterning are emerging as important tools to clarify the effects of the microenvironment on cellular behavior, as cells usually integrate and respond the microscale environment, such as chemical and mechanical properties of the surrounding fluid and extracellular matrix, soluble protein factors, small signal molecules, and contacts with neighboring cells. Furthermore, recent progress in cellular micropatterning has contributed to the development of cell-based biosensors for the functional characterization and detection of drugs, pathogens, toxicants, and odorants. In this regards, the ability to control shape and spreading of attached cells and cell-cell contacts through the form and dimension of the cell-adhesive patches with high precision is important. Commitment of stem cells to different specific lineages depends strongly on cell shape, implying that controlled microenvironments through engineered surfaces may not only be a valuable approach towards fundamental cell-biological studies, but also of great importance for the design of cell culture substrates for tissue engineering. To develop this kind of cellular microarray composed of a cell-resistant surface and cell attachment region, micropatterning a protein-repellent surface is important because cellular adhesion and proliferation are regulated by protein adsorption. The focus of this review is on the surface engineering aspects of biologically motivated micropatterning of two-dimensional surfaces with the aim to provide an introductory overview described in the literature. In particular, the importance of non-fouling surface chemistries is discussed.

  5. Directing Matter: Toward Atomic-Scale 3D Nanofabrication.

    Science.gov (United States)

    Jesse, Stephen; Borisevich, Albina Y; Fowlkes, Jason D; Lupini, Andrew R; Rack, Philip D; Unocic, Raymond R; Sumpter, Bobby G; Kalinin, Sergei V; Belianinov, Alex; Ovchinnikova, Olga S

    2016-06-28

    Enabling memristive, neuromorphic, and quantum-based computing as well as efficient mainstream energy storage and conversion technologies requires the next generation of materials customized at the atomic scale. This requires full control of atomic arrangement and bonding in three dimensions. The last two decades witnessed substantial industrial, academic, and government research efforts directed toward this goal through various lithographies and scanning-probe-based methods. These technologies emphasize 2D surface structures, with some limited 3D capability. Recently, a range of focused electron- and ion-based methods have demonstrated compelling alternative pathways to achieving atomically precise manufacturing of 3D structures in solids, liquids, and at interfaces. Electron and ion microscopies offer a platform that can simultaneously observe dynamic and static structures at the nano- and atomic scales and also induce structural rearrangements and chemical transformation. The addition of predictive modeling or rapid image analytics and feedback enables guiding these in a controlled manner. Here, we review the recent results that used focused electron and ion beams to create free-standing nanoscale 3D structures, radiolysis, and the fabrication potential with liquid precursors, epitaxial crystallization of amorphous oxides with atomic layer precision, as well as visualization and control of individual dopant motion within a 3D crystal lattice. These works lay the foundation for approaches to directing nanoscale level architectures and offer a potential roadmap to full 3D atomic control in materials. In this paper, we lay out the gaps that currently constrain the processing range of these platforms, reflect on indirect requirements, such as the integration of large-scale data analysis with theory, and discuss future prospects of these technologies.

  6. Template-free electrochemical nanofabrication of polyaniline nanobrush and hybrid polyaniline with carbon nanohorns for supercapacitors

    Energy Technology Data Exchange (ETDEWEB)

    Wei Di; Andrew, Piers; Ryhaenen, Tapani [Nokia Research Centre Cambridge, Broers Building, 21 J J Thomson Avenue, Cambridge CB3 0FA (United Kingdom); Wang, Haolan; Hiralal, Pritesh; Amaratunga, Gehan A J [Electrical Engineering Division, Department of Engineering, University of Cambridge, 9 J J Thomson Avenue, Cambridge CB3 0FA (United Kingdom); Hayashi, Yasuhiko, E-mail: di.wei@nokia.com, E-mail: gaja1@cam.ac.uk [Department of Materials Science, Nagoya Institute of Technology, Nagoya 466-8555 (Japan)

    2010-10-29

    Polyaniline (PANI) nanobrushes were synthesized by template-free electrochemical galvanostatic methods. When the same method was applied to the carbon nanohorn (CNH) solution containing aniline monomers, a hybrid nanostructure containing PANI and CNHs was enabled after electropolymerization. This is the first report on the template-free method to make PANI nanobrushes and homogeneous hybrid soft matter (PANI) with carbon nanoparticles. Raman spectroscopy was used to analyze the interaction between CNH and PANI. Electrochemical nanofabrication offers simplicity and good control when used to make electronic devices. Both of these materials were applied in supercapacitors and an improvement capacitive current by using the hybrid material was observed.

  7. Development of yttrium alloy ion source and its application in nanofabrication

    Energy Technology Data Exchange (ETDEWEB)

    Kukharchyk, Nadezhda [Angewandte Festkoerperphysik, Ruhr-Universitaet Bochum, Bochum (Germany); Experimentalphysik, Universitaet des Saarlandes, Saarbruecken (Germany); Neumann, Ronna; Mazarov, Swetlana; Wieck, Andreas D. [Angewandte Festkoerperphysik, Ruhr-Universitaet Bochum, Bochum (Germany); Bushev, Pavel [Experimentalphysik, Universitaet des Saarlandes, Saarbruecken (Germany); Mazarov, Paul [Raith GmbH, Dortmund (Germany)

    2016-12-15

    We present a new YAuSi Liquid Metal Alloy Ion Source (LMAIS) generating focused ion beams of yttrium ions, and its prospective applications for nanofabrication, sample preparation, lithographic and implantation processes. Working parameters of the AuSiY LMAIS are similar to other gold-silicon based LMAIS. We found anomalously high emission current of triple charged yttrium ions. Influence of yttrium implantation on optical qualities of the implanted ion-ensembles is shown in luminescence of co-implanted Erbium ions. (orig.)

  8. Development of yttrium alloy ion source and its application in nanofabrication

    Science.gov (United States)

    Kukharchyk, Nadezhda; Neumann, Ronna; Mazarov, Swetlana; Bushev, Pavel; Wieck, Andreas D.; Mazarov, Paul

    2016-12-01

    We present a new YAuSi Liquid Metal Alloy Ion Source (LMAIS) generating focused ion beams of yttrium ions, and its prospective applications for nanofabrication, sample preparation, lithographic and implantation processes. Working parameters of the AuSiY LMAIS are similar to other gold-silicon based LMAIS. We found anomalously high emission current of triple charged yttrium ions. Influence of yttrium implantation on optical qualities of the implanted ion-ensembles is shown in luminescence of co-implanted Erbium ions.

  9. Development of Yttrium alloy ion source and its application in nanofabrication

    CERN Document Server

    Kukharchyk, Nadezhda; Mazarov, Swetlana; Bushev, Pavel; Wieck, Andreas; Mazarov, Paul

    2016-01-01

    We present a new YAuSi Liquid Metal Alloy Ion Source (LMAIS), generating focused ion beams of yttrium ions, and its prospective applications for nanofabrication, sample preparation, lithographic and implantation processes. Working parameters of the AuSiY LMAIS are similar to other gold-silicon based LMAIS. We found anomalously high emission current of triple charged Yttrium ions. Influence of Yttrium implantation on optical qualities of the implanted ion-ensembles is shown in luminescence of co-implanted Erbium ions.

  10. Sugar nanowires based on cyclodextrin prepared by single particle nanofabrication technique

    Energy Technology Data Exchange (ETDEWEB)

    Watanabe, Shogo; Asano, Atsushi [Division of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871 (Japan); Seki, Shu [Division of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871 (Japan)], E-mail: seki@chem.eng.osaka-u.ac.jp; Sugimoto, Masaki; Yoshikawa, Masahito [Japan Atomic Energy Agency, Takasaki Advanced Radiation Research Institute, 1233 Watanuki-machi, Takasaki, Gunma 370-1292 (Japan); Seiichi, Tagawa [The Institute of Scientific and Industrial Research, Osaka University, 8-1, Mihogaoka, Ibaraki, Osaka 567-0047 (Japan); Tsukuda, Satoshi; Tanaka, Shun-Ichiro [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1, Katahira, Aoba-ku, Sendai 980-8577 (Japan)

    2009-12-15

    The direct formation of nanowires consisting of cyclodextrins by single particle nanofabrication technique (SPNT) is investigated in the present paper. Substittuted cyclodextrin (CD) derivatives and their composite with poly(4-bromostyrene) caused efficient cross-linking reaction upon irradiation, and gave nanostructures by SPNT. Successful visualization of the nanostructures by atomic force microscopy suggested drastic increase in the surface area of the materials based on CDs, leading to considerable increase in the selective adsorption efficiency of the molecules fit to the size of the hydrophobic holes of CDs.

  11. Sugar nanowires based on cyclodextrin prepared by single particle nanofabrication technique

    Science.gov (United States)

    Watanabe, Shogo; Asano, Atsushi; Seki, Shu; Sugimoto, Masaki; Yoshikawa, Masahito; Seiichi, Tagawa; Tsukuda, Satoshi; Tanaka, Shun-Ichiro

    2009-12-01

    The direct formation of nanowires consisting of cyclodextrins by single particle nanofabrication technique (SPNT) is investigated in the present paper. Substittuted cyclodextrin (CD) derivatives and their composite with poly(4-bromostyrene) caused efficient cross-linking reaction upon irradiation, and gave nanostructures by SPNT. Successful visualization of the nanostructures by atomic force microscopy suggested drastic increase in the surface area of the materials based on CDs, leading to considerable increase in the selective adsorption efficiency of the molecules fit to the size of the hydrophobic holes of CDs.

  12. Micro and nano-fabrication of biodegradable polymers for drug delivery.

    Science.gov (United States)

    Lu, Y; Chen, S C

    2004-09-22

    This paper presents state-of-the-art micro and nano-fabrication techniques for biodegradable polymers. Replication molding, using a rigid or elastic master, can pattern structures on a polymer surface in a submicron resolution at a low cost. Layer-by-layer rapid prototyping methods are promising in producing controlled release units with complicated geometries, release mechanisms and the ability to control microstructure and composition. Special attention is paid to the fast, flexible, and non-invasive laser fabrication techniques that have great potential in the fabrication of biodegradable polymer drug delivery devices in both a laboratory and industry scale.

  13. Enzymatic activity induced by interactions with a nanofabricated hydrophobic Si surface

    Science.gov (United States)

    Nishiyama, Katsuhiko

    2013-07-01

    The binding of peptides of 2-10 glycine residues (2-10Gly) to papain on nanofabricated hydrophobic Si surfaces was investigated by molecular dynamics and docking simulations. 5Gly, 7Gly, 9Gly, and 10Gly were distributed on sites near the active center of papain on the Si surface, while 6-10Gly were distributed on sites near the active center of free papain. The Si surface changed the substrate specificity of papain, and modification of this surface should allow full control of substrate specificity. Molecular surgery of proteins in cells may be realized using papain on specially designed surfaces.

  14. Nano-fabricated pixelated micropolarizer array for visible imaging polarimetry

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Zhigang; Cheng, Teng; Qiu, Kang; Zhang, Qingchuan, E-mail: zhangqc@ustc.edu.cn, E-mail: wgchu@nanoctr.cn; Wu, Xiaoping [CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics, University of Science and Technology of China, Hefei 230027 (China); Dong, Fengliang; Chu, Weiguo, E-mail: zhangqc@ustc.edu.cn, E-mail: wgchu@nanoctr.cn [Nanofabrication Laboratory, National Center for Nanoscience and Technology, Beijing 100190 (China)

    2014-10-15

    Pixelated micropolarizer array (PMA) is a novel concept for real-time visible imaging polarimetry. A 320 × 240 aluminum PMA fabricated by electron beam lithography is described in this paper. The period, duty ratio, and depth of the grating are 140 nm, 0.5, and 100 nm, respectively. The units are standard square structures and the metal nanowires of the grating are collimating and uniformly thick. The extinction ratio of 75 and the maximum polarization transmittance of 78.8% demonstrate that the PMA is suitable for polarization imaging. When the PMA is applied to real-time polarization imaging, the degree of linear polarization image and the angle of linear polarization image are calculated from a single frame image. The polarized target object is highlighted from the unpolarized background, and the surface contour of the target object can be reflected by the polarization angle.

  15. Tipping solutions: emerging 3D nano-fabrication/ -imaging technologies

    Science.gov (United States)

    Seniutinas, Gediminas; Balčytis, Armandas; Reklaitis, Ignas; Chen, Feng; Davis, Jeffrey; David, Christian; Juodkazis, Saulius

    2017-06-01

    The evolution of optical microscopy from an imaging technique into a tool for materials modification and fabrication is now being repeated with other characterization techniques, including scanning electron microscopy (SEM), focused ion beam (FIB) milling/imaging, and atomic force microscopy (AFM). Fabrication and in situ imaging of materials undergoing a three-dimensional (3D) nano-structuring within a 1-100 nm resolution window is required for future manufacturing of devices. This level of precision is critically in enabling the cross-over between different device platforms (e.g. from electronics to micro-/nano-fluidics and/or photonics) within future devices that will be interfacing with biological and molecular systems in a 3D fashion. Prospective trends in electron, ion, and nano-tip based fabrication techniques are presented.

  16. Nano-fabricated pixelated micropolarizer array for visible imaging polarimetry.

    Science.gov (United States)

    Zhang, Zhigang; Dong, Fengliang; Cheng, Teng; Qiu, Kang; Zhang, Qingchuan; Chu, Weiguo; Wu, Xiaoping

    2014-10-01

    Pixelated micropolarizer array (PMA) is a novel concept for real-time visible imaging polarimetry. A 320 × 240 aluminum PMA fabricated by electron beam lithography is described in this paper. The period, duty ratio, and depth of the grating are 140 nm, 0.5, and 100 nm, respectively. The units are standard square structures and the metal nanowires of the grating are collimating and uniformly thick. The extinction ratio of 75 and the maximum polarization transmittance of 78.8% demonstrate that the PMA is suitable for polarization imaging. When the PMA is applied to real-time polarization imaging, the degree of linear polarization image and the angle of linear polarization image are calculated from a single frame image. The polarized target object is highlighted from the unpolarized background, and the surface contour of the target object can be reflected by the polarization angle.

  17. Tipping solutions: emerging 3D nano-fabrication/ -imaging technologies

    Directory of Open Access Journals (Sweden)

    Seniutinas Gediminas

    2017-06-01

    Full Text Available The evolution of optical microscopy from an imaging technique into a tool for materials modification and fabrication is now being repeated with other characterization techniques, including scanning electron microscopy (SEM, focused ion beam (FIB milling/imaging, and atomic force microscopy (AFM. Fabrication and in situ imaging of materials undergoing a three-dimensional (3D nano-structuring within a 1−100 nm resolution window is required for future manufacturing of devices. This level of precision is critically in enabling the cross-over between different device platforms (e.g. from electronics to micro-/nano-fluidics and/or photonics within future devices that will be interfacing with biological and molecular systems in a 3D fashion. Prospective trends in electron, ion, and nano-tip based fabrication techniques are presented.

  18. Tipping solutions: emerging 3D nano-fabrication/ -imaging technologies

    OpenAIRE

    Seniutinas Gediminas; Balčytis Armandas; Reklaitis Ignas; Chen Feng; Davis Jeffrey; David Christian; Juodkazis Saulius

    2017-01-01

    The evolution of optical microscopy from an imaging technique into a tool for materials modification and fabrication is now being repeated with other characterization techniques, including scanning electron microscopy (SEM), focused ion beam (FIB) milling/imaging, and atomic force microscopy (AFM). Fabrication and in situ imaging of materials undergoing a three-dimensional (3D) nano-structuring within a 1−100 nm resolution window is required for future manufacturing of devices. This level of ...

  19. Nanowall pinning for enhanced pinning force in YBCO films with nanofabricated structures

    Energy Technology Data Exchange (ETDEWEB)

    Palau, A.; Rouco, V.; Luccas, R.F.; Obradors, X.; Puig, T., E-mail: teresa.puig@icmab.es

    2014-11-15

    Highlights: • High resolution lithography techniques to fabricate artificial pinning centres in high temperature superconductors. • Enhanced critical currents of YBCO films with engineered nanofabricated structures. • Controlled nano-walls with weakened superconductivity acting as strong pinning centres. - Abstract: High resolution nanofabrication tools (Focused Ion Beam and Electron Beam Lithography) have been used to fabricate nano-metric milled structures in high critical current YBCO thin films able to further increase their vortex pinning capabilities. We have demonstrated that pinning forces at 77 K and 3 T are increased by a 70–80% by proper nanostructure designs. Model systems with linear trenches and triangular blind antidots of different sizes, distribution and density have been generated and studied. We demonstrate that specific milled nanostructures can increase the total current through the system at expenses of a limited decrease of cross section. We have identified the length of fabricated nano-walls as the main parameter controlling the pinning potential of nanostructures and thus defined the optimised milling conditions and nanostructure morphology to maximise pinning efficiency.

  20. The applications of in situ electron energy loss spectroscopy to the study of electron beam nanofabrication.

    Science.gov (United States)

    Chen, Shiahn J; Howitt, David G; Gierhart, Brian C; Smith, Rosemary L; Collins, Scott D

    2009-06-01

    An in situ electron energy loss spectroscopy (EELS) technique has been developed to investigate the dynamic processes associated with electron-beam nanofabrication on thin membranes. In this article, practical applications germane to e-beam nanofabrication are illustrated with a case study of the drilling of nanometer-sized pores in silicon nitride membranes. This technique involves successive acquisitions of the plasmon-loss and the core-level ionization-loss spectra in real time, both of which provide the information regarding the hole-drilling kinetics, including two respective rates for total mass loss, individual nitrogen and silicon element depletion, and the change of the atomic bonding environment. In addition, the in situ EELS also provides an alternative method for endpoint detection with a potentially higher time resolution than by imaging. On the basis of the time evolution of in situ EELS spectra, a qualitative working model combining knock-on sputtering, irradiation-induced mass transport, and phase separation can be proposed.

  1. From integrated control to integrated farming, an experimental approach

    NARCIS (Netherlands)

    Vereijken, P.H.

    1989-01-01

    Integrated control or integrated pest management (IPM), as envisaged originally, is not being practised to any large extent in arable farming, notwithstanding considerable research efforts. The reasons for this are discussed. A more basic approach called integrated farming is suggested. Preliminary

  2. A nanofabricated, monolithic, path-separated electron interferometer

    CERN Document Server

    Agarwal, Akshay; Hobbs, Richard; van Dyck, Dirk; Berggren, Karl K

    2016-01-01

    We report a self-aligned, monolithic electron interferometer, consisting of two 45 nm thick silicon layers separated by 20 $\\mu$m. This interferometer was fabricated from a single crystal silicon cantilever on a transmission electron microscope grid by gallium focused ion-beam milling. Using this interferometer, we demonstrate beam path-separation, and obtain interference fringes in a Mach-Zehnder geometry, in an unmodified 200 kV transmission electron microscope. The fringes have a period of 0.32 nm, which corresponds to the $\\left[\\bar{1}\\bar{1}1\\right]$ lattice planes of silicon, and a maximum contrast of 15 %. This design can potentially be scaled to millimeter-scale, and used in electron holography. It can also be applied to perform fundamental physics experiments, such as interaction-free measurement with electrons.

  3. Nanofabrication of SERS Substrates for Single/Few Molecules Detection

    KAUST Repository

    Melino, Gianluca

    2015-05-04

    Raman spectroscopy is among the most widely employed methods to investigate the properties of materials in several fields of study. Evolution in materials science allowed us to fabricate suitable substrates, at the nanoscale, capable to enhance the electromagnetic field of the signals coming from the samples which at this range turn out to be in most cases singles or a few molecules. This particular variation of the classical technique is called SERS (Surface Enanched Raman Spectroscopy). In this work, the enhancement of the electromagnetic field is obtained by manipulation of the optical properties of metals with respect to their size. By using electroless deposition (bottom up technique), gold and silver nanoparticles were deposited in nanostructured patterns obtained on silicon wafers by means of electron beam lithography (top down technique). Rhodamine 6G in aqueous solution at extremely low concentration (10-8 M) was absorbed on the resultant dimers and the collection of the Raman spectra demonstrated the high efficiency of the substrates.

  4. PUBLIC INTEGRITY AND THE DIVERGENCE FROM IT

    Directory of Open Access Journals (Sweden)

    Simona‐Roxana ULMAN

    2013-12-01

    Full Text Available Public Integrity is one of the public sector’s essential objectives to attain. In contradiction, as a divergence from it, corruption is one of the persistent problems of the societies over years and it affects the credibility of public institutions and its ambassadors in front of the citizens and of the other related countries. All nations complain of corruption and, as it is observed in the Corruption Perception Index 2012, no country has a maximum score which shows that a country is totally clean. In this context, the study of the most important elements of the public integrity concept, the identification of what causes the divergence from it and the solutions detection become a relevant option for economic literature. In this context, the main objective of this paper is to emphasize the public integrity concept and its main aspects and to make a comparison between countries to achieve a large perspective of the world’s public integrity juncture.

  5. Enabling Desktop Nanofabrication with the Targeted Use of Soft Materials

    Science.gov (United States)

    Eichelsdoerfer, Daniel James

    with a simple chemical change to the composition of the elastomer. In particular, the extent of cross-linking within the elastomer is found to dictate the k the backing layer, and arrays with spring constants tuned from 7 to 150 N/m are described. Furthermore, a simple geometric model is developed that explains the low variation of k within each cantilever-free array; this stands in contrast to arrays of cantilevers, which typically show large variations of k within an array. Chapter 4 addresses the problem of individual actuation in SPL by embedding resistive heaters directly beneath the elastomeric backing layer. This actuation scheme was chosen because the elastomer used in the cantilever-free tip arrays has extraordinary thermal expansion properties, and thorough exploration of their actuation behavior shows that the heater arrays are fast (> 100 microm/s) and powerful (> 4 microm) enough for actuation. After implementing several corrections for the tip height -- a problem that is intractable without the heaters, and has never been addressed before -- printing of alkanethiols onto Au is demonstrated with a 2D array of individually actuated probes. Chapter 5 examines the hypothesis that elastomeric tips can absorb solvent and be used to transport materials in the absence of environmental solvent. This is evaluated by first using tip arrays soaked in a nonpolar solvent to pattern a hydrophobic block copolymer that cannot be patterned by traditional DPN, and is subsequently explored for the case of water uptake into the pen arrays. Surprisingly, despite their poor water retention ability, the tip arrays can store enough water to pattern hydrophilic polymers in dry environments for over 2 hours. The dynamics of the solvent absorption are captured by a simple calculation that accounts for the dynamical behavior of water retention and the backing layer thickness, thereby allowing these results to be generalized to other solvents. This exploration of the subtle and

  6. High Throughput Nanofabrication of Silicon Nanowire and Carbon Nanotube Tips on AFM Probes by Stencil-Deposited Catalysts

    DEFF Research Database (Denmark)

    Engstrøm, Daniel Southcott; Savu, Veronica; Zhu, Xueni;

    2011-01-01

    A new and versatile technique for the wafer scale nanofabrication of silicon nanowire (SiNW) and multiwalled carbon nanotube (MWNT) tips on atomic force microscope (AFM) probes is presented. Catalyst material for the SiNW and MWNT growth was deposited on prefabricated AFM probes using aligned wafer...

  7. EMBA Integration: From Rhetoric to Practice

    Science.gov (United States)

    Scott, Charles; Derrick, Frederick; Hoadley, Ellen

    2012-01-01

    For the modern business world, business education needs to molt from the cocoon of discipline silos to the integrated business education model to train the next generation of managers. Upper management problems are rarely silo specific. Managers do things right, but leaders do the right things; and executive programs exist to build business…

  8. Science Education: From Separation to Integration

    Science.gov (United States)

    Linn, Marcia C.; Gerard, Libby; Matuk, Camillia; McElhaney, Kevin W.

    2016-01-01

    Advances in technology, science, and learning sciences research over the past 100 years have reshaped science education. This chapter focuses on how investigators from varied fields of inquiry who initially worked separately began to interact, eventually formed partnerships, and recently integrated their perspectives to strengthen science…

  9. The Nanofabrication and Application of Substrates for Surface-Enhanced Raman Scattering

    Directory of Open Access Journals (Sweden)

    Xian Zhang

    2012-01-01

    Full Text Available Surface-enhanced Raman scattering (SERS was discovered in 1974 and impacted Raman spectroscopy and surface science. Although SERS has not been developed to be an applicable detection tool so far, nanotechnology has promoted its development in recent decades. The traditional SERS substrates, such as silver electrode, metal island film, and silver colloid, cannot be applied because of their enhancement factor or stability, but newly developed substrates, such as electrochemical deposition surface, Ag porous film, and surface-confined colloids, have better sensitivity and stability. Surface enhanced Raman scattering is applied in other fields such as detection of chemical pollutant, biomolecules, DNA, bacteria, and so forth. In this paper, the development of nanofabrication and application of surface-enhanced Ramans scattering substrate are discussed.

  10. The possibility of multi-layer nanofabrication via atomic force microscope-based pulse electrochemical nanopatterning.

    Science.gov (United States)

    Kim, Uksu; Morita, Noboru; Lee, Deug; Jun, Martin; Park, Jeong Woo

    2017-03-27

    Pulse electrochemical nanopatterning (PECN), a non-contact scanning probe lithography (NC-SPL) process using ultrashort voltage pulses, is based primarily on an electrochemical machining (ECM) process using localized electrochemical oxidation between a sharp tool tip and the sample surface. In this study, nanoscale oxide patterns were formed on silicon Si (100) wafer surfaces via electrochemical surface nanopatterning, by supplying external pulsed currents through non-contact atomic force microscopy. Nanoscale oxide width and height were controlled by modulating the applied pulse duration. Additionally, protruding nanoscale oxides were removed completely by simple chemical etching, showing a depressed pattern on the sample substrate surface. Nanoscale two-dimensional oxides, prepared by a localized electrochemical reaction, can be defined easily by controlling physical and electrical variables, before proceeding further to a layer-by-layer nanofabrication process.

  11. Scientific expectations from the INTEGRAL spectrometer SPI

    Science.gov (United States)

    Schoenfelder, Volker

    2003-03-01

    The spectrometer SPI - one of the two main instruments aboard ESA's INTEGRAL - is dedicated to high resolution gamma-ray line spectroscopy with modest imaging. SPI will mainly concentrate on the study of lines from radioactive isotopes. A wealth of new information is expected from interstellar line emission with narrow line profiles. But existing results are also expected from profile measurements of individual line emitting objects such as supernovae, supernova remnants, novae or stellar black hole systems. In addition, sensitive measurements of continuum emission from compact sources and from interstellar space are expected, especially in the sub-MeV region.

  12. PUBLIC INTEGRITY AND THE DIVERGENCE FROM IT

    OpenAIRE

    Simona‐Roxana ULMAN

    2013-01-01

    Public Integrity is one of the public sector’s essential objectives to attain. In contradiction, as a divergence from it, corruption is one of the persistent problems of the societies over years and it affects the credibility of public institutions and its ambassadors in front of the citizens and of the other related countries. All nations complain of corruption and, as it is observed in the Corruption Perception Index 2012, no country has a maximum score which shows that a countr...

  13. Thermoelectricity from wasted heat of integrated circuits

    KAUST Repository

    Fahad, Hossain M.

    2012-05-22

    We demonstrate that waste heat from integrated circuits especially computer microprocessors can be recycled as valuable electricity to power up a portion of the circuitry or other important accessories such as on-chip cooling modules, etc. This gives a positive spin to a negative effect of ever increasing heat dissipation associated with increased power consumption aligned with shrinking down trend of transistor dimension. This concept can also be used as an important vehicle for self-powered systemson- chip. We provide theoretical analysis supported by simulation data followed by experimental verification of on-chip thermoelectricity generation from dissipated (otherwise wasted) heat of a microprocessor.

  14. Large-Scale Nanofabrication of Designed Nanostructures Using Angled Nanospherical-Lens Lithography for Surface Enhanced Infrared Absorption Spectroscopy.

    Science.gov (United States)

    Chien, Yi-Hsin; Wang, Chang-Han; Liu, Chi-Ching; Chang, Shih-Hui; Kong, Kien Voon; Chang, Yun-Chorng

    2017-07-26

    Nanophotonics has been a focused research discipline for the past decade and has resulted in many novel concepts that promise to change human life. However, the actual penetration of this research into real products is severely limited mostly due to the slow development of economic nanofabrication. In this study, we have demonstrated a versatile and low-cost nanofabrication method referred to as "angled nanospherical-lens lithography (A-NLL)", which is able to produce large-scale and periodic nanopatterns. The nanopatterns designed within a two-dimensional polar chart can be carefully fabricated on the substrate. The fabricated patterns easily cover an area larger than 1 cm(2), which is beneficial as platforms for surface enhanced infrared absorption (SEIRA) where an expensive and bulky IR microscope is not required. We believe that the proposed A-NLL method is ideal for industrialization of future nanophotonic applications.

  15. Thermodynamic integration from classical to quantum mechanics.

    Science.gov (United States)

    Habershon, Scott; Manolopoulos, David E

    2011-12-14

    We present a new method for calculating quantum mechanical corrections to classical free energies, based on thermodynamic integration from classical to quantum mechanics. In contrast to previous methods, our method is numerically stable even in the presence of strong quantum delocalization. We first illustrate the method and its relationship to a well-established method with an analysis of a one-dimensional harmonic oscillator. We then show that our method can be used to calculate the quantum mechanical contributions to the free energies of ice and water for a flexible water model, a problem for which the established method is unstable.

  16. What is the Integral in Integral Education? From Progressive Pedagogy to Integral Pedagogy

    OpenAIRE

    Tom Murray

    2009-01-01

    Integrally-informed educational approaches have much in common with progressive (including reform, alternative, holistic, and transformative) approaches, and share many of the same values. One function of the integral approach is to provide an overarching model within which to coordinate different progressive methods. Though integral adds much more than that, descriptions of integral education sometimes sound like progressive educational principles recast with new terminology. This essay atte...

  17. Nanofabrication of high aspect ratio structures using an evaporated resist containing metal

    Science.gov (United States)

    Con, Celal; Zhang, Jian; Cui, Bo

    2014-05-01

    Organic electron beam resists are typically not resistant to the plasma etching employed to transfer the pattern into the underlying layer. Here, the authors present the incorporation of a metal hard mask material into negative resist polystyrene by co-evaporation of the polystyrene and the metal onto a substrate. With a volume ratio of 1:15 between Cr and polystyrene, this nanocomposite resist showed an etching selectivity to silicon one order higher than pure polystyrene resist. Silicon structures of 100 nm width and 3.5 μm height (aspect ratio 1:35) were obtained using a non-switching deep silicon etching recipe with SF6 and C4F8 gas. Moreover, unlike the common spin coating method, evaporated nanocomposite resist can be coated onto irregular and non-flat surfaces such as optical fibers and AFM cantilevers. As a proof of concept, we fabricated high aspect ratio structures on top of an AFM cantilever. Nanofabrication on non-flat surfaces may find applications in the fields of (AFM) tip enhanced Raman spectroscopy for chemical analysis and lab-on-fiber technology.

  18. Laser 3D micro/nanofabrication of polymers for tissue engineering applications

    Science.gov (United States)

    Danilevičius, P.; Rekštytė, S.; Balčiūnas, E.; Kraniauskas, A.; Širmenis, R.; Baltriukienė, D.; Bukelskienė, V.; Gadonas, R.; Sirvydis, V.; Piskarskas, A.; Malinauskas, M.

    2013-02-01

    In this work, we applied a constructed multi-photon polymerization system based on diode-pumped solid state femtosecond Yb:KGW laser used as pulsed irradiation light source (300 fs, 1030 nm, 200 kHz) in combination with large area high sample translation velocity (up to 300 mm/s) linear motor-driven stages (100×100×50 mm3) designed for high resolution and throughput 3D micro/nanofabrication. It enables rapid prototyping out of most polymers up to cm in scale with sub-micrometer spatial resolution. This can be used for production of three-dimensional artificial polymeric scaffolds applied for cell growth and expansion experiments as well as tissue engineering. Biocompatibilities of different acrylate, hybrid organic-inorganic and biodegradable polymeric materials were evaluated experimentally in vitro. Various in size and form scaffolds of biocompatible photopolymers were successfully fabricated having intricate 3D geometry, thus demonstrating the potential of the applied method. Adult rabbit myogenic stem cell proliferation tests show artificial scaffolds to be applicable for biomedical practice. Additionally, a micromolding technique was used for a rapid multiplication of adequate laser manufactured structures.

  19. Laser-induced periodic surface structures nanofabricated on poly(trimethylene terephthalate) spin-coated films.

    Science.gov (United States)

    Martín-Fabiani, I; Rebollar, E; Pérez, S; Rueda, D R; García-Gutiérrez, M C; Szymczyk, A; Roslaniec, Z; Castillejo, M; Ezquerra, T A

    2012-05-22

    Here we present a precise morphological description of laser-induced periodic surface structures (LIPSS) nanofabricated on spin-coated poly(trimethylene terephthalate) (PTT) films by irradiation with 266 nm, 6 ns laser pulses and by using a broad range of fluences and number of pulses. By accomplishing real and reciprocal space measurements by means of atomic force microscopy and grazing incidence wide- and small-angle X-ray scattering respectively on LIPSS samples, the range of optimum structural order has been established. For a given fluence, an increase in the number of pulses tends to improve LIPSS in PTT. However, as the pulse doses increase above a certain limit, a distortion of the structures is observed and a droplet-like morphology appears. It is proposed that this effect could be related to a plausible decrease of the molecular weight of PTT due to laser-induced chain photo-oxidation by irradiation with a high number of pulses. A concurrent decrease in viscosity enables destabilization of LIPSS by the formation of droplets in a process similar to surface-limited dewetting.

  20. From waste treatment to integrated resource management.

    Science.gov (United States)

    Wilsenach, J A; Maurer, M; Larsen, T A; van Loosdrecht, M C M

    2003-01-01

    Wastewater treatment was primarily implemented to enhance urban hygiene. Treatment methods were improved to ensure environmental protection by nutrient removal processes. In this way, energy is consumed and resources like potentially useful minerals and drinking water are disposed of. An integrated management of assets, including drinking water, surface water, energy and nutrients would be required to make wastewater management more sustainable. Exergy analysis provides a good method to quantify different resources, e.g. utilisable energy and nutrients. Dilution is never a solution for pollution. Waste streams should best be managed to prevent dilution of resources. Wastewater and sanitation are not intrinsically linked. Source separation technology seems to be the most promising concept to realise a major breakthrough in wastewater treatment. Research on unit processes, such as struvite recovery and treatment of ammonium rich streams, also shows promising results. In many cases, nutrient removal and recovery can be combined, with possibilities for a gradual change from one system to another.

  1. Sustainable NREL: From Integration to Innovation

    Energy Technology Data Exchange (ETDEWEB)

    2015-09-01

    NREL's sustainability practices are integrated throughout the laboratory and are essential to our mission to develop clean energy and energy efficiency technologies and practices, advance related science and engineering, and provide knowledge and innovations to integrate energy systems at all scales. Sustainability initiatives are integrated through our campus, our staff, and our environment allowing NREL to provide leadership in modeling a sustainability energy future for companies, organizations, governments, and communities.

  2. Integrated communications: From one look to normative consistency

    DEFF Research Database (Denmark)

    Torp, Simon

    2009-01-01

    and conceptual development in relation to the range and scope of integrated communication.   Findings The ideal of integration in connection with marketing communication is not new. The analysis shows that the IMC field is marked by great diversity and disagreement. The ideal scope of integration has expanded...... ambitious interpretations of the concept the integration endeavour extends from the external integration of visual design to the internal integration of the organization's culture and "soul".   Design/methodology/approach The paper is based on a critical and thematic reading of the integrated marketing...

  3. Studying Teacher Selection of Resources in an Ultra-Large Scale Interactive System: Does Metadata Guide the Way?

    Science.gov (United States)

    Abramovich, Samuel; Schunn, Christian

    2012-01-01

    Ultra-large-scale interactive systems on the Internet have begun to change how teachers prepare for instruction, particularly in regards to resource selection. Consequently, it is important to look at how teachers are currently selecting resources beyond content or keyword search. We conducted a two-part observational study of an existing popular…

  4. Avoiding unintentional eviction from integral projection models.

    Science.gov (United States)

    Williams, Jennifer L; Miller, Tom E X; Ellner, Stephen P

    2012-09-01

    Integral projection models (IPMs) are increasingly being applied to study size-structured populations. Here we call attention to a potential problem in their construction that can have important consequences for model results. IPMs are implemented using an approximating matrix and bounded size range. Individuals near the size limits can be unknowingly "evicted" from the model because their predicted future size is outside the range. We provide simple measures for the magnitude of eviction and the sensitivity of the population growth rate (lambda) to eviction, allowing modelers to assess the severity of the problem in their IPM. For IPMs of three plant species, we found that eviction occurred in all cases and caused underestimation of the population growth rate (lambda) relative to eviction-free models; it is likely that other models are similarly affected. Models with frequent eviction should be modified because eviction is only possible when size transitions are badly mis-specified. We offer several solutions to eviction problems, but we emphasize that the modeler must choose the most appropriate solution based on an understanding of why eviction occurs in the first place. We recommend testing IPMs for eviction problems and resolving them, so that population dynamics are modeled more accurately.

  5. Integral and measure from rather simple to rather complex

    CERN Document Server

    Mackevicius, Vigirdas

    2014-01-01

    This book is devoted to integration, one of the two main operations in calculus. In Part 1, the definition of the integral of a one-variable function is different (not essentially, but rather methodically) from traditional definitions of Riemann or Lebesgue integrals. Such an approach allows us, on the one hand, to quickly develop the practical skills of integration as well as, on the other hand, in Part 2, to pass naturally to the more general Lebesgue integral. Based on the latter, in Part 2, the author develops a theory of integration for functions of several variables. In Part 3, within

  6. Integrating curvature: from Umlaufsatz to J^+ invariant

    CERN Document Server

    Lanzat, Sergei

    2011-01-01

    Hopf's Umlaufsatz relates the total curvature of a closed immersed plane curve to its rotation number. While the curvature of a curve changes under local deformations, its integral over a closed curve is invariant under regular homotopies. A natural question is whether one can find some non-trivial densities on a curve, such that the corresponding integrals are (possibly after some corrections) also invariant under regular homotopies of the curve in the class of generic immersions. We construct a family of such densities using indices of points relative to the curve. This family depends on a formal parameter q and may be considered as a quantization of the total curvature. The linear term in the Taylor expansion at q=1 coincides, up to a normalization, with Arnold's J^+ invariant. This leads to an integral expression for J^+.

  7. From Social Simulation to Integrative System Design

    CERN Document Server

    Helbing, Dirk

    2010-01-01

    As the recent financial crisis showed, today there is a strong need to gain "ecological perspective" of all relevant interactions in socio-economic-techno-environmental systems. For this, we suggested to set-up a network of Centers for integrative systems design, which shall be able to run all potentially relevant scenarios, identify causality chains, explore feedback and cascading effects for a number of model variants, and determine the reliability of their implications (given the validity of the underlying models). They will be able to detect possible negative side effect of policy decisions, before they occur. The Centers belonging to this network of Integrative Systems Design Centers would be focused on a particular field, but they would be part of an attempt to eventually cover all relevant areas of society and economy and integrate them within a "Living Earth Simulator". The results of all research activities of such Centers would be turned into informative input for political Decision Arenas. For exam...

  8. Local integration of refugees: reflections from Liberian refugees in Ghana

    OpenAIRE

    Acheampong, Anthony

    2015-01-01

    This study examines the local integration of former Liberian refugees in Ghana. The objective is to provide insight into the program based mainly on the reflections and views of individual refugees who are taking part in the integration program. This is done not only to gain a better understanding of the phenomenon, but also, ascertain the real impact of the integration program in the refugees’ lives. To this end, the study draws on 14 qualitative interviews from integrating refugees, and off...

  9. Academic Information Systems: From Segregation to Integration.

    Science.gov (United States)

    Bernbom, Gerald; And Others

    1992-01-01

    Through integration of administrative information systems across diverse technology platforms and opening access to institutional data, Indiana University has begun to expand the concept of academic information systems. The university's experience has resulted in conclusions and guidelines for other institutions to use in AIS planning and…

  10. OPE in planar QCD from integrability

    CERN Document Server

    Ahn, Changrim; Nepomechie, Rafael I

    2012-01-01

    We consider the operator product expansion of local single-trace operators composed of the self-dual components of the field strength tensor in planar QCD. Using the integrability of the one-loop matrix of anomalous dimensions of such operators, we obtain a determinant expression for certain tree-level structure constants in the OPE.

  11. Results from the First INTEGRAL AGN Catalogue

    CERN Document Server

    Beckmann, V; Shrader, C R; Gehrels, N

    2005-01-01

    We present results based on the first INTEGRAL AGN catalogue. The catalogue includes 42 AGN, of which 10 are Seyfert 1, 17 are Seyfert 2, and 9 are intermediate Seyfert 1.5. The fraction of blazars is rather small with 5 detected objects, and only one galaxy cluster and no star-burst galaxies have been detected so far. The sample consists of bright (fx > 5e-12 erg/cm**2/s), low luminosity (L = 2e43 erg/s), local (z = 0.020) AGN. Although the sample is not flux limited, we find a ratio of obscured to unobscured AGN of 1.5 - 2.0, consistent with luminosity dependent unified models for AGN. Only four Compton-thick AGN are found in the sample. This implies that the missing Compton-thick AGN needed to explain the cosmic hard X-ray background would have to have lower fluxes than discovered by INTEGRAL so far.

  12. Integrable Lattice Models From Gauge Theory

    CERN Document Server

    Witten, Edward

    2016-01-01

    These notes provide an introduction to recent work by Kevin Costello in which integrable lattice models of classical statistical mechanics in two dimensions are understood in terms of quantum gauge theory in four dimensions. This construction will be compared to the more familiar relationship between quantum knot invariants in three dimensions and Chern-Simons gauge theory. (Based on a Whittaker Colloquium at the University of Edinburgh and a lecture at Strings 2016 in Beijing.)

  13. Multidisciplinary integration in the context of integrated care – results from the North West London Integrated Care Pilot

    Directory of Open Access Journals (Sweden)

    Matthew Harris

    2013-10-01

    Full Text Available Background: In the context of integrated care, Multidisciplinary Group (MDG meetings involve participants from diverse professional groups and organizations and are potential vehicles to advance efficiency improvements within the local health economy.  We advance a novel method to evaluate the effectiveness of MDGs by measuring the extent to which participants integrate within MDG meetings and whether this integration leads to improved working. Methods: We purposively selected four MDG meetings, and conducted a content analysis of audio-recorded and transcribed case discussions. Two coders independently coded utterances according to their ‘integrative intensity’ which was defined against three a priori independent domains – the Level (i.e. Individual, Collective and Systems; the Valence (Problem, Information and Solution; the Focus (Concrete and Abstract. Inter- and intra-rater reliability was tested with Kappa scores on one randomly selected Case Discussion.  Standardized weighted mean integration scores were calculated for Case Discussions across utterance deciles, indicating how integrative intensity changed during the conversations. Results: Twenty-three Case Discussions in four different MDG groups were transcribed and coded. Inter- and intra-rater reliability was good as shown by the Prevalence and Bias Adjusted Kappa Scores for one randomly selected Case Discussion.  There were differences in the proportion of utterances per participant type (Consultant 14.6%; Presenting GP 38.75%; Chair 7.8%; Non-Presenting GP 2.25%; Allied Health Professional 4.8%. Utterances were predominantly coded at low levels of integrative intensity; however there was a gradual increase (R2=0.66 in integrative intensity during the Case Discussions.  Based on analysis of the minutes and action points arising from the Case Discussions, this improved integration did not translate into actions moving forward. Interpretation: We characterize the MDGs as

  14. Cross-Order Integral Relations from Maximal Cuts

    CERN Document Server

    Johansson, Henrik; Larsen, Kasper J.; Søgaard, Mads

    2015-01-01

    We study the ABDK relation using maximal cuts of one- and two-loop integrals with up to five external legs. We show how to find a special combination of integrals that allows the relation to exist, and how to reconstruct the terms with one-loop integrals squared. The reconstruction relies on the observation that integrals across different loop orders can have support on the same generalized unitarity cuts and can share global poles. We discuss the appearance of nonhomologous integration contours in multivariate residues. Their origin can be understood in simple terms, and their existence enables us to distinguish contributions from different integrals. Our analysis suggests that maximal and near-maximal cuts can be used to infer the existence of integral identities more generally.

  15. Phosphorus removal from secondary effluents through integrated constructed treatment system.

    Science.gov (United States)

    Xiong, Jibing; Qin, Yong; Mahmood, Qaisar; Liu, Hanhu; Yang, Dejun

    2011-01-01

    The treatment capacity of an integrated constructed treatment system (CTS) was explored which was designed to reduce phosphorus (P) from secondary effluents. The integrated CTS was combined with vertical-flow constructed wetland, floating bed and sand filter. The vertical wetland was filled from the bottom to the top with gravels, steel slag and peat. Vetiverzizanioides (L.) Nash was selected to grow in the vertical constructed wetland while Coixlacrymajobi L. was grown in floating bed. The results suggested that integrated CTS displayed excellent removal efficiency for chemical oxygen demand (COD), dissolved phosphorus (DP), and total phosphorus (TP). The average COD removal efficiency of the integrated CTS was 90.45% after 40 days of operation, the average DP and TP removal efficiencies of the integrated CTS were 97.43% and 96.40%, respectively. The integrated CTS has good potential in removing COD as well as P from secondary effluents. Copyright © 2011 Elsevier Ltd. All rights reserved.

  16. Nanofabrication de boites quantiques laterales pour l'optimisation de qubits de spin

    Science.gov (United States)

    Camirand Lemyre, Julien

    On présente dans ce travail un nouveau type de qubit de spin dont les performances reposent sur les propriétés d'un seul électron dans une double boîte quantique. Le fort moment dipolaire de la double boite combiné à une large variation du champ magnétique entre les deux boîtes permettrait de réaliser des opérations logiques plus rapidement que dans une seule boîte quantique. Pour maximiser les variations du champ magnétique, on utilisera un micro-aimant placé le plus près possible d'une des deux boîtes. À cette fin, une hétérostructure de GaAs/A1GaAs sur laquelle sont déposées des grilles d'aluminium a été utilisée pour former une double boite quantique latérale. L'occupation par un seul électron de la double boîte est confirmée par des mesures de transport électrique à basse température ainsi que par l'observation du blocage de spin. De plus, un procédé d'oxydation des grilles par plasma d'oxygène a été développé. Une étude des propriétés de l'oxyde formé par cette méthode montre qu'il est possible de placer un micro-aimant directement sur la surface de l'hétérostructure sans affecter l'isolation électrique entre les grilles. Cette nouvelle approche permet de produire des champs magnétiques encore plus intenses que dans les expériences antérieures, pour lesquelles le micro-aimant est placé beaucoup plus loin de la surface. L'ensemble du procédé de fabrication, de la photolithographie à l'électrolithographie, a été développé au cours de ce travail dans les salles blanches du département de génie électrique et dans les salles propres du département de physique de l'Université de Sherbrooke. Ce travail est une étape importante dans la réalisation de qubits de spin plus performants dans les boîtes quantiques latérales. Mots-clés: Information quantique, Spin, Rotations ultra-rapides, Boîtes quantiques latérales, Micro-aimants, Oxydation plasma, Nanofabrication.

  17. From clinical integration to accountable care.

    Science.gov (United States)

    Shields, Mark

    2011-01-01

    Four key challenges to reforming health care organizations can be addressed by a clinical integration model patterned after Advocate Physician Partners (APP). These challenges are: predominance of small group practices, dominant fee-for-service reimbursement methods, weaknesses of the traditional hospital medical staff structure and a need to partner with commercial insurance companies. APP has demonstrated teamwork between 3800 physicians and hospitals to improve quality, patient safety and cost-effectiveness. Building on this model, an innovative contract with Blue Cross Blue Shield of Illinois serves as a prototype for a commercial Accountable Care Organization. For this contract to succeed, APP must outperform the market competition. To accomplish this, APP has implemented strategies to reduce readmissions, avoid unnecessary admissions and emergency room visits, expand primary care access, and enhance quality and patient safety.

  18. Psychiatry and neurology: from dualism to integration.

    Science.gov (United States)

    Sobański, Jerzy A; Dudek, Dominika

    2013-01-01

    The two objectives of the following paper are: to make few remarks on the topic absorbing neurologists, psychiatrists, and neuropsychiatrists - integration and division of their specialties; and to describe the situation in Poland, reflected in the latest literature. The authors describe the former and present processes of approaches and divisions in psychiatry and neurology. They indicate dissemination of mutual methods of structural and action brain neuroimaging, neurophysiology, neurogenetics, and advanced neurophysiology diagnostics. As it seems, even the effectiveness of psychotherapy, has recently been associated with changes in brain in functional and even structural markers. The authors indicate the value of the strive to join the still divided specialties, reflected worldwide in attempts of common education and clinical cooperation of physicians. It can be expected that subsequent years will bring further triumphs of neuropsychiatry - a field that combines psychiatry and neurology.

  19. Symbols of one-loop integrals from mixed Tate motives

    Science.gov (United States)

    Spradlin, Marcus; Volovich, Anastasia

    2011-11-01

    We use a result on mixed Tate motives due to Goncharov [1] to show that the symbol of an arbitrary one-loop 2 m-gon integral in 2 m dimensions may be read off directly from its Feynman parameterization. The algorithm proceeds via recursion in m seeded by the well-known box integrals in four dimensions. As a simple application of this method we write down the symbol of a three-mass hexagon integral in six dimensions.

  20. ASEAN Integration: Potential and Learning from Experience from Europe

    OpenAIRE

    Egill Helgason 1989

    2017-01-01

    This thesis puts the regional integration process in South-East Asia under the scope. It looks at the Association of Southeast Asian Nations (ASEAN), and analyses its position and potential by examining the history, structure and policies of the organization and the domestic policies of the member states, with a comparison between its integration process and that of the European Union. ASEAN has a declared goal of establishing an organization that is highly integrated and cohesive. ASE...

  1. Thermoresponsive nanofabricated substratum for the engineering of three-dimensional tissues with layer-by-layer architectural control.

    Science.gov (United States)

    Jiao, Alex; Trosper, Nicole E; Yang, Hee Seok; Kim, Jinsung; Tsui, Jonathan H; Frankel, Samuel D; Murry, Charles E; Kim, Deok-Ho

    2014-05-27

    Current tissue engineering methods lack the ability to properly recreate scaffold-free, cell-dense tissues with physiological structures. Recent studies have shown that the use of nanoscale cues allows for precise control over large-area 2D tissue structures without restricting cell growth or cell density. In this study, we developed a simple and versatile platform combining a thermoresponsive nanofabricated substratum (TNFS) incorporating nanotopographical cues and the gel casting method for the fabrication of scaffold-free 3D tissues. Our TNFS allows for the structural control of aligned cell monolayers which can be spontaneously detached via a change in culture temperature. Utilizing our gel casting method, viable, aligned cell sheets can be transferred without loss of anisotropy or stacked with control over individual layer orientations. Transferred cell sheets and individual cell layers within multilayered tissues robustly retain structural anisotropy, allowing for the fabrication of scaffold-free, 3D tissues with hierarchical control of overall tissue structure.

  2. Micro/nanofabrication of poly({sub L}-lactic acid) using focused ion beam direct etching

    Energy Technology Data Exchange (ETDEWEB)

    Oyama, Tomoko Gowa; Nagasawa, Naotsugu; Taguchi, Mitsumasa [Quantum Beam Science Directorate, Japan Atomic Energy Agency, 1233 Watanuki-machi, Takasaki, Gunma 370-1292 (Japan); Hinata, Toru; Washio, Masakazu [Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555 (Japan); Oshima, Akihiro; Tagawa, Seiichi [Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555 (Japan); The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047 (Japan)

    2013-10-14

    Micro/nanofabrication of biocompatible and biodegradable poly({sub L}-lactic acid) (PLLA) using focused Ga ion beam direct etching was evaluated for future bio-device applications. The fabrication performance was determined with different ion fluences and fluxes (beam currents), and it was found that the etching speed and fabrication accuracy were affected by irradiation-induced heat. Focused ion beam (FIB)-irradiated surfaces were analyzed using micro-area X-ray photoelectron spectroscopy. Owing to reactions such as the physical sputtering of atoms and radiation-induced decomposition, PLLA was gradually carbonized with increasing C=C bonds. Controlled micro/nanostructures of PLLA were fabricated with C=C bond-rich surfaces expected to have good cell attachment properties.

  3. Integration Of Data From Heterogeneous Sources Using Etl Technology.

    Directory of Open Access Journals (Sweden)

    Marek Macura

    2014-01-01

    Full Text Available Data integration is a crucial issue in environments of heterogeneous data sources. At present mentioned heterogeneity is becoming widespread. Whenever, based on various data sources, we want to gain useful information and knowledge we must solve data integration problem in order to apply appropriate analytical methods on comprehensive and uniform data. Such activity is known as knowledge discovery from data process. Therefore approaches to data integration problem are very interesting and bring us closer to the "age of information". The paper presents an architecture, which implements knowledge discovery from data process. The solution combines ETL technology and wrapper layer known from mediated systems. It also provides semantic integration through connections mechanism between data elements. The solution allows for integration of any data sources and implementation of analytical methods in one environment. The proposed environment is verified by applying it to data sources on the foundry industry.

  4. Accurate Kirkwood-Buff Integrals from Molecular Dynamics Simulations

    DEFF Research Database (Denmark)

    Wedberg, Nils Hejle Rasmus Ingemar; O'Connell, John P.; Peters, Günther H.J.

    2010-01-01

    A method is proposed for obtaining thermodynamic properties via Kirkwood–Buff (KB) integrals from molecular simulations. In order to ensure that the KB integration converges, the pair distribution function is extrapolated to large distances using the extension method of Verlet, which enforces...

  5. Integration

    DEFF Research Database (Denmark)

    Emerek, Ruth

    2004-01-01

    Bidraget diskuterer de forskellige intergrationsopfattelse i Danmark - og hvad der kan forstås ved vellykket integration......Bidraget diskuterer de forskellige intergrationsopfattelse i Danmark - og hvad der kan forstås ved vellykket integration...

  6. [Integrity].

    Science.gov (United States)

    Gómez Rodríguez, Rafael Ángel

    2014-01-01

    To say that someone possesses integrity is to claim that that person is almost predictable about responses to specific situations, that he or she can prudentially judge and to act correctly. There is a closed interrelationship between integrity and autonomy, and the autonomy rests on the deeper moral claim of all humans to integrity of the person. Integrity has two senses of significance for medical ethic: one sense refers to the integrity of the person in the bodily, psychosocial and intellectual elements; and in the second sense, the integrity is the virtue. Another facet of integrity of the person is la integrity of values we cherish and espouse. The physician must be a person of integrity if the integrity of the patient is to be safeguarded. The autonomy has reduced the violations in the past, but the character and virtues of the physician are the ultimate safeguard of autonomy of patient. A field very important in medicine is the scientific research. It is the character of the investigator that determines the moral quality of research. The problem arises when legitimate self-interests are replaced by selfish, particularly when human subjects are involved. The final safeguard of moral quality of research is the character and conscience of the investigator. Teaching must be relevant in the scientific field, but the most effective way to teach virtue ethics is through the example of the a respected scientist.

  7. Nanofabrication for On-Chip Optical Levitation, Atom-Trapping, and Superconducting Quantum Circuits

    Science.gov (United States)

    Norte, Richard Alexander

    Researchers have spent decades refining and improving their methods for fabricating smaller, finer-tuned, higher-quality nanoscale optical elements with the goal of making more sensitive and accurate measurements of the world around them using optics. Quantum optics has been a well-established tool of choice in making these increasingly sensitive measurements which have repeatedly pushed the limits on the accuracy of measurement set forth by quantum mechanics. A recent development in quantum optics has been a creative integration of robust, high-quality, and well-established macroscopic experimental systems with highly-engineerable on-chip nanoscale oscillators fabricated in cleanrooms. However, merging large systems with nanoscale oscillators often require them to have extremely high aspect-ratios, which make them extremely delicate and difficult to fabricate with an experimentally reasonable repeatability, yield and high quality. In this work we give an overview of our research, which focused on microscopic oscillators which are coupled with macroscopic optical cavities towards the goal of cooling them to their motional ground state in room temperature environments. The quality factor of a mechanical resonator is an important figure of merit for various sensing applications and observing quantum behavior. We demonstrated a technique for pushing the quality factor of a micromechanical resonator beyond conventional material and fabrication limits by using an optical field to stiffen and trap a particular motional mode of a nanoscale oscillator. Optical forces increase the oscillation frequency by storing most of the mechanical energy in a nearly loss-less optical potential, thereby strongly diluting the effects of material dissipation. By placing a 130 nm thick SiO2 pendulum in an optical standing wave, we achieve an increase in the pendulum center-of-mass frequency from 6.2 to 145 kHz. The corresponding quality factor increases 50-fold from its intrinsic value to

  8. GDH Integral on the Proton from Asymmetries

    Energy Technology Data Exchange (ETDEWEB)

    Yelena Prok

    2004-05-01

    Inclusive double spin electron asymmetries have been measured by scattering polarized electrons off the solid polarized {sup 15}NH{sub 3} target in Hall B of Jefferson Lab in 2000-2001. The virtual photon asymmetry A{sub 1} (x), the longitudinal spin structure function, g{sub 1} (x, Q{sup 2}), and the first moment, {Gamma}{sub 1}{sup p}, have been evaluated for a kinematic range of 0.05 {ge} Q{sup 2} {ge} 4.5 GeV{sup 2}. The extracted results complement the existing data in the resonance region, extending it to lower and higher Q{sup 2} regions. The results are important in the study of Q{sup 2} evolution of nucleon structure from the hadronic to partonic degrees of freedom.

  9. GDH Integral on the Proton from Asymmetries

    Energy Technology Data Exchange (ETDEWEB)

    Prok, Yelena [Univ. of Virginia, Charlottesville, VA (United States)

    2004-05-01

    Inclusive double spin electron asymmetries have been measured by scattering polarized electrons off the solid polarized 15NH3 target in Hall B of Jefferson Lab in 2000-2001. The virtual photon asymmetry A1 (x), the longitudinal spin structure function, g1 (x, Q2), and the first moment, γ1p, have been evaluated for a kinematic range of 0.05 ≥ Q2 ≥ 4.5 GeV2. The extracted results complement the existing data in the resonance region, extending it to lower and higher Q2 regions. The results are important in the study of Q2 evolution of nucleon structure from the hadronic to partonic degrees of freedom.

  10. Barriers and facilitators to integrating care: experiences from the English Integrated Care Pilots.

    Science.gov (United States)

    Ling, Tom; Brereton, Laura; Conklin, Annalijn; Newbould, Jennifer; Roland, Martin

    2012-01-01

    In 2008, the English Department of Health appointed 16 'Integrated Care Pilots' which used a range of approaches to provide better integrated care. We report qualitative analyses from a three-year multi-method evaluation to identify barriers and facilitators to successful integration of care. Data were analysed from transcripts of 213 in-depth staff interviews, and from semi-structured questionnaires (the 'Living Document') completed by staff in pilot sites at six points over a two-year period. Emerging findings were therefore built from 'bottom up' and grounded in the data. However, we were then interested in how these findings compared and contrasted with more generic analyses. Therefore after our analyses were complete we then systematically compared and contrasted the findings with the analysis of barriers and facilitators to quality improvement identified in a systematic review by Kaplan et al. (2010) and the analysis of more micro-level shapers of behaviour found in Normalisation Process Theory (May et al. 2007). Neither of these approaches claims to be full blown theories but both claim to provide mid-range theoretical arguments which may be used to structure existing data and which can be undercut or reinforced by new data. Many barriers and facilitators to integrating care are those of any large-scale organisational change. These include issues relating to leadership, organisational culture, information technology, physician involvement, and availability of resources. However, activities which appear particularly important for delivering integrated care include personal relationships between leaders in different organisations, the scale of planned activities, governance and finance arrangements, support for staff in new roles, and organisational and staff stability. We illustrate our analyses with a 'routemap' which identifies questions that providers may wish to consider when planning interventions to improve the integration of care.

  11. Barriers and facilitators to integrating care: experiences from the English Integrated Care Pilots

    Directory of Open Access Journals (Sweden)

    Tom Ling

    2012-07-01

    Full Text Available Background. In 2008, the English Department of Health appointed 16 'Integrated Care Pilots' which used a range of approaches to provide better integrated care. We report qualitative analyses from a three year multi-method evaluation to identify barriers and facilitators to successful integration of care. Theory and methods. Data were analysed from transcripts of 213 in-depth staff interviews, and from semi-structured questionnaires (the 'Living Document' completed by staff in pilot sites at six points over a two-year period. Emerging findings were therefore built from 'bottom up' and grounded in the data. However, we were then interested in how these findings compared and contrasted with more generic analyses. Therefore after our analyses were complete we then systematically compared and contrasted the findings with the analysis of barriers and facilitators to quality improvement identified in a systematic review by Kaplan et al (2010 and the analysis of more micro-level shapers of behaviour found in Normalisation Process Theory (May et al 2007. Neither of these approaches claims to be full blown theories but both claim to provide mid-range theoretical arguments which may be used to structure existing data and which can be undercut or reinforced by new data.Results and discussion. Many barriers and facilitators to integrating care are those of any large scale organisational change. These include issues relating to leadership, organisational culture, information technology, physician involvement, and availability of resources. However, activities which appear particularly important for delivering integrated care include personal relationships between leaders in different organisations, the scale of planned activities, governance and finance arrangements, support for staff in new roles, and organisational and staff stability. We illustrate our analyses with a 'routemap' which identifies questions that providers may wish to consider when planning

  12. Barriers and facilitators to integrating care: experiences from the English Integrated Care Pilots

    Directory of Open Access Journals (Sweden)

    Tom Ling

    2012-07-01

    Full Text Available Background. In 2008, the English Department of Health appointed 16 'Integrated Care Pilots' which used a range of approaches to provide better integrated care. We report qualitative analyses from a three year multi-method evaluation to identify barriers and facilitators to successful integration of care.  Theory and methods. Data were analysed from transcripts of 213 in-depth staff interviews, and from semi-structured questionnaires (the 'Living Document' completed by staff in pilot sites at six points over a two-year period. Emerging findings were therefore built from 'bottom up' and grounded in the data. However, we were then interested in how these findings compared and contrasted with more generic analyses. Therefore after our analyses were complete we then systematically compared and contrasted the findings with the analysis of barriers and facilitators to quality improvement identified in a systematic review by Kaplan et al (2010 and the analysis of more micro-level shapers of behaviour found in Normalisation Process Theory (May et al 2007. Neither of these approaches claims to be full blown theories but both claim to provide mid-range theoretical arguments which may be used to structure existing data and which can be undercut or reinforced by new data. Results and discussion. Many barriers and facilitators to integrating care are those of any large scale organisational change. These include issues relating to leadership, organisational culture, information technology, physician involvement, and availability of resources. However, activities which appear particularly important for delivering integrated care include personal relationships between leaders in different organisations, the scale of planned activities, governance and finance arrangements, support for staff in new roles, and organisational and staff stability. We illustrate our analyses with a 'routemap' which identifies questions that providers may wish to consider when

  13. Does integrated governance lead to integrated patient care? Findings from the innovation forum.

    Science.gov (United States)

    Beech, Roger; Henderson, Catherine; Ashby, Sue; Dickinson, Angela; Sheaff, Rod; Windle, Karen; Wistow, Gerald; Knapp, Martin

    2013-11-01

    Good integration of services that aim to reduce avoidable acute hospital bed use by older people requires frontline staff to be aware of service options and access them in a timely manner. In three localities where closer inter-organisational integration was taking place, this research sought patients' perceptions of the care received across and within organisational boundaries. Between February and July 2008, qualitative methods were used to map the care journeys of 18 patients (six from each site). Patient interviews (46) covered care received before, at the time of and following a health crisis. Additional interviews (66) were undertaken with carers and frontline staff. Grounded theory-based approaches showed examples of well-integrated care against a background of underuse of services for preventing health crises and a reliance on 'traditional' referral patterns and services at the time of a health crisis. There was scope to raise both practitioner and patient awareness of alternative care options and to expand the availability and visibility of care 'closer to home' services such as rapid response teams. Concerns voiced by patients centred on the adequacy of arrangements for organising ongoing care, while family members reported being excluded from discussions about care arrangements and the roles they were expected to play. The coordination of care was also affected by communication difficulties between practitioners (particularly across organisational boundaries) and a lack of compatible technologies to facilitate information sharing. Finally, closer organisational integration seemed to have limited impact on care at the patient/practitioner interface. To improve care experienced by patients, organisational integration needs to be coupled with vertical integration within organisations to ensure that strategic goals influence the actions of frontline staff. As they experience the complete care journey, feedback from patients can play an important role in the

  14. Quantum tunneling splittings from path-integral molecular dynamics

    Science.gov (United States)

    Mátyus, Edit; Wales, David J.; Althorpe, Stuart C.

    2016-03-01

    We illustrate how path-integral molecular dynamics can be used to calculate ground-state tunnelling splittings in molecules or clusters. The method obtains the splittings from ratios of density matrix elements between the degenerate wells connected by the tunnelling. We propose a simple thermodynamic integration scheme for evaluating these elements. Numerical tests on fully dimensional malonaldehyde yield tunnelling splittings in good overall agreement with the results of diffusion Monte Carlo calculations.

  15. Position-resolved Surface Characterization and Nanofabrication Using an Optical Microscop e Combined with a Nanopip ette/Quartz Tuning Fork Atomic Force Microscop e

    Institute of Scientific and Technical Information of China (English)

    Sangmin An; Baekman Sung; Haneol Noh; Corey Stambaugh; Soyoung Kwon; Kunyoung Lee; Bongsu Kim; Qhwan Kim; Wonho Jhe

    2014-01-01

    In this work, we introduce position-resolved surface characterization and nanofabrication us-ing an optical microscope (OM) combined with a nanopipette-based quartz tuning fork atomic force micro-scope (nanopipette/QTF-AFM) system. This system is used to accurately determine substrate position and nanoscale phenomena under ambient conditions. Solutions consisting of 5 nm Au nanoparticles, nanowires, and polydimethylsiloxane (PDMS) are deposited onto the substrate through the nano/microaperture of a pulled pipette. Nano/microscale patterning is performed using a nanopipette/QTF-AFM, while position is resolved by monitoring the substrate with a custom OM. With this tool, one can perform surface characterization (force spectroscopy/microscopy) using the quartz tuning fork (QTF) sensor. Nanofabrication is achieved by accu-rately positioning target materials on the surface, and on-demand delivery and patterning of various solutions for molecular architecture.

  16. National Call for Organizational Change from Sheltered to Integrated Employment

    Science.gov (United States)

    Rogan, Patricia; Rinne, Susan

    2011-01-01

    Our purpose in this article is to contend that organizational change from sheltered to integrated employment is not only possible but necessary, and a federal Employment First agenda must be advanced. Findings are reported from interviews with senior managers from 10 organizations that have shifted their service delivery to community employment,…

  17. National Call for Organizational Change from Sheltered to Integrated Employment

    Science.gov (United States)

    Rogan, Patricia; Rinne, Susan

    2011-01-01

    Our purpose in this article is to contend that organizational change from sheltered to integrated employment is not only possible but necessary, and a federal Employment First agenda must be advanced. Findings are reported from interviews with senior managers from 10 organizations that have shifted their service delivery to community employment,…

  18. A systematic construction of completely integrable Hamiltonians from coalgebras

    CERN Document Server

    Ballesteros, A; Ballesteros, Angel; Ragnisco, Orlando

    1998-01-01

    A universal algorithm to construct N-particle (classical and quantum) completely integrable Hamiltonian systems from representations of coalgebras with Casimir element is presented. In particular, this construction shows that quantum deformations can be interpreted as generating structures for integrable deformations of Hamiltonian systems with coalgebra symmetry. In order to illustrate this general method, the $so(2,1)$ algebra and the oscillator algebra $h_4$ are used to derive new classical integrable systems including a generalization of Gaudin-Calogero systems and oscillator chains. Quantum deformations are then used to obtain some explicit integrable deformations of the previous long-range interacting systems and a (non-coboundary) deformation of the $(1+1)$ Poincaré algebra is shown to provide a new Ruijsenaars-Schneider-like Hamiltonian.

  19. Integrating Ecological and Social Knowledge: Learning from CHANS Research

    Directory of Open Access Journals (Sweden)

    Bruce Shindler

    2017-03-01

    Full Text Available Scientists are increasingly called upon to integrate across ecological and social disciplines to tackle complex coupled human and natural system (CHANS problems. Integration of these disciplines is challenging and many scientists do not have experience with large integrated research projects. However, much can be learned about the complicated process of integration from such efforts. We document some of these lessons from a National Science Foundation-funded CHANS project (Forests, People, Fire and present considerations for developing and engaging in coupled human and natural system projects. Certainly we are not the first to undertake this endeavor, and many of our findings complement those of other research teams. We focus here on the process of coming together, learning to work as an integrated science team, and describe the challenges and opportunities of engaging stakeholders (agency personnel and citizen communities of interests in our efforts. Throughout this project our intention was to foster dialogue among diverse interests and, thus, incorporate this knowledge into uncovering primary social and ecological drivers of change. A primary tool was an agent-based model, Envision, that used this information in landscape simulation, visualization models, and scenario development. Although integration can be an end in itself, the proof of value in the approach can be the degree to which it provides new insights or tools to CHANS, including closer interaction among multiple stakeholders, that could not have been reached without it.

  20. Defining nephrotic syndrome from an integrative genomics perspective.

    Science.gov (United States)

    Sampson, Matthew G; Hodgin, Jeffrey B; Kretzler, Matthias

    2015-01-01

    Nephrotic syndrome (NS) is a clinical condition with a high degree of morbidity and mortality, caused by failure of the glomerular filtration barrier, resulting in massive proteinuria. Our current diagnostic, prognostic and therapeutic decisions in NS are largely based upon clinical or histological patterns such as "focal segmental glomerulosclerosis" or "steroid sensitive". Yet these descriptive classifications lack the precision to explain the physiologic origins and clinical heterogeneity observed in this syndrome. A more precise definition of NS is required to identify mechanisms of disease and capture various clinical trajectories. An integrative genomics approach to NS applies bioinformatics and computational methods to comprehensive experimental, molecular and clinical data for holistic disease definition. A unique aspect is analysis of data together to discover NS-associated molecules, pathways, and networks. Integrating multidimensional datasets from the outset highlights how molecular lesions impact the entire individual. Data sets integrated range from genetic variation to gene expression, to histologic changes, to progression of chronic kidney disease (CKD). This review will introduce the tenets of integrative genomics and suggest how it can increase our understanding of NS from molecular and pathophysiological perspectives. A diverse group of genome-scale experiments are presented that have sought to define molecular signatures of NS. Finally, the Nephrotic Syndrome Study Network (NEPTUNE) will be introduced as an international, prospective cohort study of patients with NS that utilizes an integrated systems genomics approach from the outset. A major NEPTUNE goal is to achieve comprehensive disease definition from a genomics perspective and identify shared molecular drivers of disease.

  1. Integrating order and distance relationships from heterogeneous maps.

    Science.gov (United States)

    Graves, M

    1993-01-01

    There is no automatic mechanism to integrate information between heterogeneous genome maps. Currently, integration is a difficult, manual process. We have developed a process for knowledge base design, and we use this to integrate order and distance relationships between genetic linkage, radiation hybrid, and physical maps. Until now, the only way to develop a persistent, knowledge-intensive application was to either develop a new knowledge base from scratch or coerce the application to fit an existing knowledge base. This was not from lack of interest by the knowledge base or database community, but merely from a lack of theoretical tools powerful enough to tackle the problem. We import formalisms from knowledge representation, natural language semantics, programming language research, and databases. These form a strong, theoretical foundation for knowledge base design upon which we have implemented the knowledge base design tool called WEAVE.

  2. Integration of Point Clouds Dataset from Different Sensors

    Science.gov (United States)

    Abdullah, C. K. A. F. Che Ku; Baharuddin, N. Z. S.; Ariff, M. F. M.; Majid, Z.; Lau, C. L.; Yusoff, A. R.; Idris, K. M.; Aspuri, A.

    2017-02-01

    Laser Scanner technology become an option in the process of collecting data nowadays. It is composed of Airborne Laser Scanner (ALS) and Terrestrial Laser Scanner (TLS). ALS like Phoenix AL3-32 can provide accurate information from the viewpoint of rooftop while TLS as Leica C10 can provide complete data for building facade. However if both are integrated, it is able to produce more accurate data. The focus of this study is to integrate both types of data acquisition of ALS and TLS and determine the accuracy of the data obtained. The final results acquired will be used to generate models of three-dimensional (3D) buildings. The scope of this study is focusing on data acquisition of UTM Eco-home through laser scanning methods such as ALS which scanning on the roof and the TLS which scanning on building façade. Both device is used to ensure that no part of the building that are not scanned. In data integration process, both are registered by the selected points among the manmade features which are clearly visible in Cyclone 7.3 software. The accuracy of integrated data is determined based on the accuracy assessment which is carried out using man-made registration methods. The result of integration process can achieve below 0.04m. This integrated data then are used to generate a 3D model of UTM Eco-home building using SketchUp software. In conclusion, the combination of the data acquisition integration between ALS and TLS would produce the accurate integrated data and able to use for generate a 3D model of UTM eco-home. For visualization purposes, the 3D building model which generated is prepared in Level of Detail 3 (LOD3) which recommended by City Geographic Mark-Up Language (CityGML).

  3. Monopolistic Market Position and Losses from Monetary Integration

    Directory of Open Access Journals (Sweden)

    Paweł Młodkowski

    2009-12-01

    Full Text Available The objective of the paper is to show how a market position influences company’s gains and losses from monetary integration. The literature on monetary integration already features cost and benefit analysis. However the proposed examples of both results (negative and positive are not offered for different market structures and most often are macroeconomic in nature. The paper develops an idea that a monopolistic enterprise might be worse off because of monetary integration. The case discussed, shows that prior to monetary integration, a specific solution regarding pricing of imported goods allowed the company for: (1 hedging effectively from exchange rate risk, (2 benefiting from long-term appreciation trend of the domestic currency against the euro. Both goals were achieved due to privileged market position (legal monopoly of the company. The monetary integration and the expected full EMU accession is going to remove the need for hedging but simultaneously it will result in loosing the ability to achieve extra profits extracted so far. This is a basis for a claim that costs and benefits flowing from monetary integration could depend on market structure an entity operates in. We conclude that in a more monopolized economies, the microeconomic benefits achieved by households are at the cost of firms, while in a perfect competition gains are uniformly distributed across agents at supply and demand sides of markets. Therefore, producers in monopolized economies could be less prone to join a monetary union. The opposite hypothesis might also be true. In economies with fewer monopolies there are fewer incentives to oppose monetary integration. The comparison of the two extreme settings allows posting a hypothesis that the perfect competition is monetary integration-neutral and the monopoly is monetary integration-averse market structure. Data for the paper and the studied case are originating from one of the largest legal monopolists in Poland that

  4. From Classical Nonlinear Integrable Systems to Quantum Shortcuts to Adiabaticity

    Science.gov (United States)

    Okuyama, Manaka; Takahashi, Kazutaka

    2016-08-01

    Using shortcuts to adiabaticity, we solve the time-dependent Schrödinger equation that is reduced to a classical nonlinear integrable equation. For a given time-dependent Hamiltonian, the counterdiabatic term is introduced to prevent nonadiabatic transitions. Using the fact that the equation for the dynamical invariant is equivalent to the Lax equation in nonlinear integrable systems, we obtain the counterdiabatic term exactly. The counterdiabatic term is available when the corresponding Lax pair exists and the solvable systems are classified in a unified and systematic way. Multisoliton potentials obtained from the Korteweg-de Vries equation and isotropic X Y spin chains from the Toda equations are studied in detail.

  5. Integrated information theory: from consciousness to its physical substrate.

    Science.gov (United States)

    Tononi, Giulio; Boly, Melanie; Massimini, Marcello; Koch, Christof

    2016-07-01

    In this Opinion article, we discuss how integrated information theory accounts for several aspects of the relationship between consciousness and the brain. Integrated information theory starts from the essential properties of phenomenal experience, from which it derives the requirements for the physical substrate of consciousness. It argues that the physical substrate of consciousness must be a maximum of intrinsic cause-effect power and provides a means to determine, in principle, the quality and quantity of experience. The theory leads to some counterintuitive predictions and can be used to develop new tools for assessing consciousness in non-communicative patients.

  6. Integrated TiO2 resonators for visible photonics

    CERN Document Server

    Choy, Jennifer T; Deotare, Parag B; Burgess, Ian B; Evans, Christopher C; Mazur, Eric; Loncar, Marko

    2011-01-01

    We demonstrate waveguide-coupled titanium dioxide (TiO2) racetrack resonators with loaded quality factors of 2x10^4 for the visible wavelengths. The structures were fabricated in sputtered TiO2 thin films on oxidized silicon substrates using standard top-down nanofabrication techniques, and passively probed in transmission measurements using a tunable red laser. Devices based on this material could serve as integrated optical elements as well as passive platforms for coupling to visible quantum emitters.

  7. On holographic three point functions for GKP strings from integrability

    CERN Document Server

    Kazama, Yoichi

    2011-01-01

    Adapting the powerful integrability-based formalism invented previously for the calculation of gluon scattering amplitudes at strong coupling, we develop a method for computing the holographic three point functions for the large spin limit of Gubser-Klebanov- Polyakov (GKP) strings. Although many of the ideas from the gluon scattering problem can be transplanted with minor modifications, the fact that the information of the external states is now encoded in the singularities at the vertex insertion points necessitates several new techniques. Notably, we develop a new generalized Riemann bilinear identity, which allows one to express the area integral in terms of appropriate contour integrals in the presence of such singularities. We also give some general discussions on how semiclassical vertex operators for heavy string states should be constructed systematically from the solutions of the Hamilton-Jacobi equation.

  8. Bottom-Up Nanofabrication of Supported Noble Metal Alloy Nanoparticle Arrays for Plasmonics

    DEFF Research Database (Denmark)

    Nugroho, Ferry A. A.; Iandolo, Beniamino; Wagner, Jakob Birkedal;

    2016-01-01

    Mixing different elements at the nanoscale to obtain alloy nanostructures with fine-tuned physical and chemical properties offers appealing opportunities for nanotechnology and nanoscience. However, despite widespread successful application of alloy nanoparticles made by colloidal synthesis...... in heterogeneous catalysis, nanoalloy systems have been used very rarely in solid-state devices and nanoplasmonics-related applications. One reason is that such applications require integration in arrays on a surface with compelling demands on nanoparticle arrangement, uniformity in surface coverage...... the concept, we focus on Au-based binary and ternary alloy systems with Ag, Cu, and Pd, due to their high relevance for nanoplasmonics and complete miscibility, and characterize their optical properties. Moreover, as an example for the relevance of the obtained materials for integration in devices, we...

  9. Serotyping of Salmonella Isolates from Broiler Vertical Integrations in Colombia

    Science.gov (United States)

    This study analyzed 106 Salmonella isolates from different points in broiler vertical integrations of two important poultry areas of Colombia. It was possible to identify the presence of Salmonella in five categories: breeder farm (17.9%), hatchery (6.6 %), broiler farm (38.7 %), processing plant (9...

  10. Financial integration in Europe : Evidence from Euler equation tests

    NARCIS (Netherlands)

    Lemmen, J.J.G.; Eijffinger, S.C.W.

    1995-01-01

    This paper applies Obstfeld's Euler equation tests to assess the degree of financial integration in the European Union. In addition, we design a new Euler equation test which is intimately related to Obstfeld's Euler equation tests. Using data from the latest Penn World Table (Mark 6), we arrive at

  11. Integrative medicine selects best practice from public health and biomedicine

    Directory of Open Access Journals (Sweden)

    Terence J Ryan

    2013-01-01

    Full Text Available The meaning of terms Integrated and Integrative are described variously by an amalgam of latest scientific advances with ancient healing systems, of complementary medicine and biomedicine, and sexually transmitted infections and HIV/AIDS. It means seamless good quality care between hospital and primary care. They provoke approval mostly from patients and disapproval mostly from advocates of science and evidence-based medicine. The Institute of Applied Dermatology in Kasaragod, Kerala, India has championed a mix of Biomedicine, Yoga and herbals from Ayurvedic medicine, partly based on publications from the Department of Dermatology of the University of Oxford. In Oxford dermatology, acceptance of value of integrative medicine (IM is demonstrated, especially in wound healing and the skin′s blood supply. This has long featured in the university′s research program. A variety of approaches to the practice of medicine are illustrated with reference to Osler, Garrod, and Doll. IM is believed to underlie contemporarily best practice. Particular emphasis is given to the control of heat, pain, redness, and swelling, all manifestations of inflammation, and the importance of emotion as a stimulus or inhibitor carried by neural pathways. These may explain some unbelievable Asian practices and one of the many roles of Yoga. The concept of Integrative is expanded to include care of the earth and nutrition, the hazards of climate change, Gardens for Health, do (k no (w harm as a key to good practice.

  12. When Can Information from Ordinal Scale Variables Be Integrated?

    Science.gov (United States)

    Kemp, Simon; Grace, Randolph C.

    2010-01-01

    Many theoretical constructs of interest to psychologists are multidimensional and derive from the integration of several input variables. We show that input variables that are measured on ordinal scales cannot be combined to produce a stable weakly ordered output variable that allows trading off the input variables. Instead a partial order is…

  13. p-adic Gauss integrals from the Poison summarizing formula

    CERN Document Server

    Prokhorenko, D V

    2011-01-01

    In the present paper we show how to obtain the well-known formula for Gauss sums and the Gauss reciprocity low from the Poison summarizing formula by using some ideas of renormalization and ergodic theories. We also apply our method to obtain new simple derivation of the standard formula for p-adic Gauss integrals.

  14. Business intelligence guidebook from data integration to analytics

    CERN Document Server

    Sherman, Rick

    2015-01-01

    Between the high-level concepts of business intelligence and the nitty-gritty instructions for using vendors’ tools lies the essential, yet poorly-understood layer of architecture, design and process. Without this knowledge, Big Data is belittled – projects flounder, are late and go over budget. Business Intelligence Guidebook: From Data Integration to Analytics shines a bright light on an often neglected topic, arming you with the knowledge you need to design rock-solid business intelligence and data integration processes. Practicing consultant and adjunct BI professor Rick Sherman takes the guesswork out of creating systems that are cost-effective, reusable and essential for transforming raw data into valuable information for business decision-makers. After reading this book, you will be able to design the overall architecture for functioning business intelligence systems with the supporting data warehousing and data-integration applications. You will have the information you need to get a project laun...

  15. Mining and integration of pathway diagrams from imaging data.

    Science.gov (United States)

    Kozhenkov, Sergey; Baitaluk, Michael

    2012-03-01

    Pathway diagrams from PubMed and World Wide Web (WWW) contain valuable highly curated information difficult to reach without tools specifically designed and customized for the biological semantics and high-content density of the images. There is currently no search engine or tool that can analyze pathway images, extract their pathway components (molecules, genes, proteins, organelles, cells, organs, etc.) and indicate their relationships. Here, we describe a resource of pathway diagrams retrieved from article and web-page images through optical character recognition, in conjunction with data mining and data integration methods. The recognized pathways are integrated into the BiologicalNetworks research environment linking them to a wealth of data available in the BiologicalNetworks' knowledgebase, which integrates data from >100 public data sources and the biomedical literature. Multiple search and analytical tools are available that allow the recognized cellular pathways, molecular networks and cell/tissue/organ diagrams to be studied in the context of integrated knowledge, experimental data and the literature. BiologicalNetworks software and the pathway repository are freely available at www.biologicalnetworks.org. Supplementary data are available at Bioinformatics online.

  16. Bottom-Up Nanofabrication of Supported Noble Metal Alloy Nanoparticle Arrays for Plasmonics.

    Science.gov (United States)

    Nugroho, Ferry A A; Iandolo, Beniamino; Wagner, Jakob B; Langhammer, Christoph

    2016-02-23

    Mixing different elements at the nanoscale to obtain alloy nanostructures with fine-tuned physical and chemical properties offers appealing opportunities for nanotechnology and nanoscience. However, despite widespread successful application of alloy nanoparticles made by colloidal synthesis in heterogeneous catalysis, nanoalloy systems have been used very rarely in solid-state devices and nanoplasmonics-related applications. One reason is that such applications require integration in arrays on a surface with compelling demands on nanoparticle arrangement, uniformity in surface coverage, and optimization of the surface density. These cannot be fulfilled even using state-of-the-art self-assembly strategies of colloids. As a solution, we present here a generic bottom-up nanolithography-compatible fabrication approach for large-area arrays of alloy nanoparticles on surfaces. To illustrate the concept, we focus on Au-based binary and ternary alloy systems with Ag, Cu, and Pd, due to their high relevance for nanoplasmonics and complete miscibility, and characterize their optical properties. Moreover, as an example for the relevance of the obtained materials for integration in devices, we demonstrate the superior and hysteresis-free plasmonic hydrogen-sensing performance of the AuPd alloy nanoparticle system.

  17. Integrated process for preparing a carboxylic acid from an alkane

    Science.gov (United States)

    Benderly, Abraham; Chadda, Nitin; Sevon, Douglass

    2011-12-20

    The present invention relates to an integrated process for producing unsaturated carboxylic acids from the corresponding C.sub.2-C.sub.4 alkane. The process begins with performance of thermally integrated dehydrogenation reactions which convert a C.sub.2-C.sub.4 alkane to its corresponding C.sub.2-C.sub.4 alkene, and which involve exothermically converting a portion of an alkane to its corresponding alkene by oxidative dehydrogenation in an exothermic reaction zone, in the presence of oxygen and a suitable catalyst, and then feeding the products of the exothermic reaction zone to an endothermic reaction zone wherein at least a portion of the remaining unconverted alkane is endothermically dehydrogenated to form an additional quantity of the same corresponding alkene, in the presence of carbon dioxide and an other suitable catalyst. The alkene products of the thermally integrated dehydrogenation reactions are then provided to a catalytic vapor phase partial oxidation process for conversion of the alkene to the corresponding unsaturated carboxylic acid or nitrile. Unreacted alkene and carbon dioxide are recovered from the oxidation product stream and recycled back to the thermally integrated dehydrogenation reactions.

  18. INTEGRAL non detection of renewed activity from Terzan 5

    DEFF Research Database (Denmark)

    Vovk, I.; Kuulkers, E.; Chenevez, Jérôme;

    2011-01-01

    Cluster. From the JEM-X mosaic, we estimated a 5 sigma upper limit of 6 mCrab in the 3-10 keV energy band (effective exposure time 5.2 ks). The 5 sigma upper limit in the 20-40 keV energy band derived from the IBIS/ISGRI data was of 11 mCrab (effective exposure 12 ks). The INTEGRAL observations took place...

  19. European Integration and Outward FDI from Central and Eastern Europe

    DEFF Research Database (Denmark)

    Jindra, B.; Hassan, S. S.; Gunther, J.

    2015-01-01

    The European Union (EU) Member States in central and eastern Europe (CEE) witnessed a surge in outward foreign direct investment (OFDI) between 2000 and the start of the global financial crisis. This article investigates whether the European integration process altered the relative importance...... of host country location factors. In particular, we investigate to what extent knowledge-seeking is a relevant investment motive, which has been documented as a key determinant for OFDI from other emerging economies. We apply a discrete choice approach to model foreign location choice of firms from CEE...... countries (CEECs) within the EU 27 (1996-2010). We find that the EU integration process is related with increasing importance of market access and less emphasis on labour cost advantages. We find heterogeneity in the valuation of foreign knowledge-related assets. The location probability within the EU15...

  20. INTEGRAL non detection of renewed activity from Terzan 5

    DEFF Research Database (Denmark)

    Vovk, I.; Kuulkers, E.; Chenevez, Jérôme

    2011-01-01

    Cluster. From the JEM-X mosaic, we estimated a 5 sigma upper limit of 6 mCrab in the 3-10 keV energy band (effective exposure time 5.2 ks). The 5 sigma upper limit in the 20-40 keV energy band derived from the IBIS/ISGRI data was of 11 mCrab (effective exposure 12 ks). The INTEGRAL observations took place...... about 8 hours before the RXTE detection reported in Atel #3714, and thus probably just before the onset of renewed activity. Due to Sun visibility constraints, no other INTEGRAL observations in the direction of Terzan 5 are planned for the next months....

  1. Nanofabrication by electrochemical routes of Ni-coated ordered arrays of carbon nanotubes

    Science.gov (United States)

    Tamburri, Emanuela; Toschi, Francesco; Guglielmotti, Valeria; Scatena, Elisa; Orlanducci, Silvia; Terranova, Maria Letizia

    2009-08-01

    Ordered arrays of carbon nanotubes (CNT) have been coated by Ni nanoparticles and Ni thin films by using the chronoamperometry technique for nickel reduction. Two different kinds of nanotube arrays have been used: aligned bundles of CNT grown on Si substrates by chemical vapour deposition (CVD) and networks of CNT bundles positioned via a dielectrophoretic post-synthesis process between the electrodes of a multifinger device. The morphology and structure of the Ni-coated CNT bundles have been characterized by field emission scanning electron microscopy (FE-SEM) and X-ray diffraction (XRD). By changing the parameters of the electrochemical process, it is possible to modulate the morphological characteristics of the Ni deposits, which can be obtained in form of nanoparticles uniformly distributed along the whole length of the CNT bundles or of Ni thin films. A qualitative study of the nucleation and growth mechanism of Ni onto CNT has been performed using the theoretical model for diffusion-controlled electrocrystallization, and a correlation between growth mechanism and samples morphology is presented and discussed. The possibility to maintain the architecture of the pristine nanotube deposits after the Ni coating process opens new perspectives for integration of CNT/Ni systems in magnetic and spintronics devices.

  2. Integrated pest management: theoretical insights from a threshold policy.

    Science.gov (United States)

    Costa, Michel I da Silveira; Faria, Lucas Del B

    2010-01-01

    An Integrated Pest Management is formulated as a threshold policy. It is shown that when this strategy is applied to a food web consisting of generalist, specialist predators and endemic and pest prey, the dynamics can be stable and useful from the pest control point of view, despite the dynamical complexities inherent to the application of biocontrol only. In addition, pesticide toxicity depends rather on the species intrinsic parameters than on the chemical agent concentration.

  3. Team Teaching: Integrating Research and Lessons from the Field

    Science.gov (United States)

    2013-11-01

    USSOCOM RESEARCH CONDUCTED BY: SWA CONSULTING INC. Team teaching: Integrating research and lessons from the field Olin , J., & Harman, R. P. (2013...and Contributors: Mr. Hyderhusain Abadin Ms. Lindsey Jeralds Mrs. Cristina Lambert Mr. Jack  Olin Dr. Daniel Stanhope Dr. Eric A. Surface Sponsored by

  4. Integrated pest management: theoretical insights from a threshold policy

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Michel I. da Silveira [Laboratorio Nacional de Computacao Cientifica (LNCC), Petropolis, RJ (Brazil)], e-mail: michel@lncc.br; Faria, Lucas del B. [Universidade Federal de Lavras, MG (Brazil). Dept. de Biologia. Setor de Ecologia], e-mail: lucasdbf@gmail.com

    2010-01-15

    An Integrated Pest Management is formulated as a threshold policy. It is shown that when this strategy is applied to a food web consisting of generalist, specialist predators and endemic and pest prey, the dynamics can be stable and useful from the pest control point of view, despite the dynamical complexities inherent to the application of biocontrol only. In addition, pesticide toxicity depends rather on the species intrinsic parameters than on the chemical agent concentration. (author)

  5. INTEGRAL detects renewed activity from IGR J11435-6109

    DEFF Research Database (Denmark)

    Fiocchi, M.; Chenevez, J.; Sguera, V.

    2015-01-01

    During a recent INTEGRAL public observation of Musca region, performed between 2015-12-11 17:54 and 2015-12-12 12:54 (UTC), renewed activity from the transient X-ray pulsar IGR J11435-6109 has been detected. The 22-60 keV IBIS/ISGRI flux corresponds to (10+/-1) mCrab with an effective exposure time...

  6. Enabling the Internet of Things from integrated circuits to integrated systems

    CERN Document Server

    2017-01-01

    This book offers the first comprehensive view on integrated circuit and system design for the Internet of Things (IoT), and in particular for the tiny nodes at its edge. The authors provide a fresh perspective on how the IoT will evolve based on recent and foreseeable trends in the semiconductor industry, highlighting the key challenges, as well as the opportunities for circuit and system innovation to address them. This book describes what the IoT really means from the design point of view, and how the constraints imposed by applications translate into integrated circuit requirements and design guidelines. Chapter contributions equally come from industry and academia. After providing a system perspective on IoT nodes, this book focuses on state-of-the-art design techniques for IoT applications, encompassing the fundamental sub-systems encountered in Systems on Chip for IoT: ultra-low power digital architectures and circuits low- and zero-leakage memories (including emerging technologies) circuits for hardwar...

  7. Integration of plastids with their hosts: Lessons learned from dinoflagellates.

    Science.gov (United States)

    Dorrell, Richard G; Howe, Christopher J

    2015-08-18

    After their endosymbiotic acquisition, plastids become intimately connected with the biology of their host. For example, genes essential for plastid function may be relocated from the genomes of plastids to the host nucleus, and pathways may evolve within the host to support the plastid. In this review, we consider the different degrees of integration observed in dinoflagellates and their associated plastids, which have been acquired through multiple different endosymbiotic events. Most dinoflagellate species possess plastids that contain the pigment peridinin and show extreme reduction and integration with the host biology. In some species, these plastids have been replaced through serial endosymbiosis with plastids derived from a different phylogenetic derivation, of which some have become intimately connected with the biology of the host whereas others have not. We discuss in particular the evolution of the fucoxanthin-containing dinoflagellates, which have adapted pathways retained from the ancestral peridinin plastid symbiosis for transcript processing in their current, serially acquired plastids. Finally, we consider why such a diversity of different degrees of integration between host and plastid is observed in different dinoflagellates and how dinoflagellates may thus inform our broader understanding of plastid evolution and function.

  8. From molecules to behavior and the clinic: Integration in chronobiology.

    Science.gov (United States)

    Bechtel, William

    2013-12-01

    Chronobiology, especially the study of circadian rhythms, provides a model scientific field in which philosophers can study how investigators from a variety of disciplines working at different levels of organization are each contributing to a multi-level account of the responsible mechanism. I focus on how the framework of mechanistic explanation integrates research designed to decompose the mechanism with efforts directed at recomposition that relies especially on computation models. I also examine how recently the integration has extended beyond basic research to the processes through which the disruption of circadian rhythms contributes to disease, including various forms of cancer. Understanding these linkages has been facilitated by discoveries about how circadian mechanisms interact with mechanisms involved in other physiological processes, including the cell cycle and the immune system.

  9. Accuracy of Star Cluster Parameters from Integrated UBVRIJHK Photometry

    CERN Document Server

    Bridzius, A; Stonkute, R; Deveikis, V; Vansevicius, V

    2009-01-01

    We investigate the capability of the UBVRIJHK photometric system to quantify star clusters in terms of age, metallicity and color excess by their integrated photometry in the framework of PEGASE single stellar population (SSP) models. The age-metallicity-extinction degeneracy was analyzed for various parameter combinations, assuming different levels of photometric accuracy. We conclude, that most of the parameter degeneracies, typical to the UBVRI photometric system, are broken in the case when the photometry data are supplemented with at least one infrared magnitude of the JHK passbands, with an accuracy better than ~0.05 mag. The presented analysis with no preassumptions on the distribution of photometric errors of star cluster models, provides estimate of the intrinsic capability of any photometric system to determine star cluster parameters from integrated photometry.

  10. Software for systems biology: from tools to integrated platforms.

    Science.gov (United States)

    Ghosh, Samik; Matsuoka, Yukiko; Asai, Yoshiyuki; Hsin, Kun-Yi; Kitano, Hiroaki

    2011-11-03

    Understanding complex biological systems requires extensive support from software tools. Such tools are needed at each step of a systems biology computational workflow, which typically consists of data handling, network inference, deep curation, dynamical simulation and model analysis. In addition, there are now efforts to develop integrated software platforms, so that tools that are used at different stages of the workflow and by different researchers can easily be used together. This Review describes the types of software tools that are required at different stages of systems biology research and the current options that are available for systems biology researchers. We also discuss the challenges and prospects for modelling the effects of genetic changes on physiology and the concept of an integrated platform.

  11. Reexamination of molecular integrals arising from the Dirac equation. Analytical evaluation of molecular auxiliary functions integrals

    CERN Document Server

    Bagci, A

    2016-01-01

    The author in his previous works were presented a numerical integration method, namely, global-adaptive with the Gauss-Kronrod numerical integration extension in order to accurate calculation of molecular auxiliary functions integrals involve power functions with non-integer exponents. They are constitute elements of molecular integrals arising in Dirac equation when Slater-type orbitals with non-integer principal quantum numbers are used. Binomial series representation of power functions method, so far, is used for analytical evaluation of the molecular auxiliary function integrals however, intervals of integration cover areas beyond the condition of convergence. In the present study, analytical evaluation of these integrals is re-examined. They are expressed via prolate spheroidal coordinates. An alternative analytical approximation are derived. Slowly convergent binomial series representation formulae for power functions is investigated through nonlinear sequence transformations for the acceleration of con...

  12. 'Integration'

    DEFF Research Database (Denmark)

    Olwig, Karen Fog

    2011-01-01

    After a long history dominated by out-migration, Denmark, Norway and Sweden have, in the past 50 years, become immigration societies. This article compares how these Scandinavian welfare societies have sought to incorporate immigrants and refugees into their national communities. It suggests that......, while the countries have adopted disparate policies and ideologies, differences in the actual treatment and attitudes towards immigrants and refugees in everyday life are less clear, due to parallel integration programmes based on strong similarities in the welfare systems and in cultural notions...... of equality in the three societies. Finally, it shows that family relations play a central role in immigrants’ and refugees’ establishment of a new life in the receiving societies, even though the welfare society takes on many of the social and economic functions of the family....

  13. Integrated superconducting detectors on semiconductors for quantum optics applications

    Science.gov (United States)

    Kaniber, M.; Flassig, F.; Reithmaier, G.; Gross, R.; Finley, J. J.

    2016-05-01

    Semiconductor quantum photonic circuits can be used to efficiently generate, manipulate, route and exploit nonclassical states of light for distributed photon-based quantum information technologies. In this article, we review our recent achievements on the growth, nanofabrication and integration of high-quality, superconducting niobium nitride thin films on optically active, semiconducting GaAs substrates and their patterning to realize highly efficient and ultra-fast superconducting detectors on semiconductor nanomaterials containing quantum dots. Our state-of-the-art detectors reach external detection quantum efficiencies up to 20 % for ~4 nm thin films and single-photon timing resolutions <72 ps. We discuss the integration of such detectors into quantum dot-loaded, semiconductor ridge waveguides, resulting in the on-chip, time-resolved detection of quantum dot luminescence. Furthermore, a prototype quantum optical circuit is demonstrated that enabled the on-chip generation of resonance fluorescence from an individual InGaAs quantum dot, with a linewidth <15 μeV displaced by 1 mm from the superconducting detector on the very same semiconductor chip. Thus, all key components required for prototype quantum photonic circuits with sources, optical components and detectors on the same chip are reported.

  14. European Integration and Outward FDI from Central and Eastern Europe

    DEFF Research Database (Denmark)

    Jindra, B.; Hassan, S. S.; Gunther, J.

    2015-01-01

    The European Union (EU) Member States in central and eastern Europe (CEE) witnessed a surge in outward foreign direct investment (OFDI) between 2000 and the start of the global financial crisis. This article investigates whether the European integration process altered the relative importance...... of host country location factors. In particular, we investigate to what extent knowledge-seeking is a relevant investment motive, which has been documented as a key determinant for OFDI from other emerging economies. We apply a discrete choice approach to model foreign location choice of firms from CEE...

  15. Assessing the environmental sustainability of ethanol from integrated biorefineries.

    Science.gov (United States)

    Falano, Temitope; Jeswani, Harish K; Azapagic, Adisa

    2014-06-01

    This paper considers the life cycle environmental sustainability of ethanol produced in integrated biorefineries together with chemicals and energy. Four types of second-generation feedstocks are considered: wheat straw, forest residue, poplar, and miscanthus. Seven out of 11 environmental impacts from ethanol are negative, including greenhouse gas (GHG) emissions, when the system is credited for the co-products, indicating environmental savings. Ethanol from poplar is the best and straw the worst option for most impacts. Land use change from forest to miscanthus increases the GHG emissions several-fold. For poplar, the effect is opposite: converting grassland to forest reduces the emissions by three-fold. Compared to fossil and first-generation ethanol, ethanol from integrated biorefineries is more sustainable for most impacts, with the exception of wheat straw. Pure ethanol saves up to 87% of GHG emissions compared to petrol per MJ of fuel. However, for the current 5% ethanol-petrol blends, the savings are much smaller (<3%). Therefore, unless much higher blends become widespread, the contribution of ethanol from integrated biorefineries to the reduction of GHG emissions will be insignificant. Yet, higher ethanol blends would lead to an increase in some impacts, notably terrestrial and freshwater toxicity as well as eutrophication for some feedstocks. © 2014 The Authors. Biotechnology Journal published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

  16. Wearable smart systems: from technologies to integrated systems.

    Science.gov (United States)

    Lymberis, A

    2011-01-01

    Wearable technology and integrated systems, so called Smart Wearable Systems (SWS) have demonstrated during the last 10-15 years significant advances in terms of, miniaturisation, seamless integration, data processing & communication, functionalisation and comfort. This is mainly due to the huge progress in sciences and technologies e.g. biomedical and micro & nano technologies, but also to a strong demand for new applications such as continuous personal health monitoring, healthy lifestyle support, human performance monitoring and support of professionals at risk. Development of wearable systems based of smart textile have, in addition, benefited from the eagerness of textile industry to develop new value-added apparel products like functionalized garments and smart clothing. Research and development in these areas has been strongly promoted worldwide. In Europe the major R&D activities were supported through the Information & Communication Technologies (ICT) priority of the R&D EU programs. The paper presents and discusses the main achievements towards integrated systems as well as future challenges to be met in order to reach a market with reliable and high value-added products.

  17. From social integration to health: Durkheim in the new millennium.

    Science.gov (United States)

    Berkman, L F; Glass, T; Brissette, I; Seeman, T E

    2000-09-01

    It is widely recognized that social relationships and affiliation have powerful effects on physical and mental health. When investigators write about the impact of social relationships on health, many terms are used loosely and interchangeably including social networks, social ties and social integration. The aim of this paper is to clarify these terms using a single framework. We discuss: (1) theoretical orientations from diverse disciplines which we believe are fundamental to advancing research in this area; (2) a set of definitions accompanied by major assessment tools; and (3) an overarching model which integrates multilevel phenomena. Theoretical orientations that we draw upon were developed by Durkheim whose work on social integration and suicide are seminal and John Bowlby, a psychiatrist who developed attachment theory in relation to child development and contemporary social network theorists. We present a conceptual model of how social networks impact health. We envision a cascading causal process beginning with the macro-social to psychobiological processes that are dynamically linked together to form the processes by which social integration effects health. We start by embedding social networks in a larger social and cultural context in which upstream forces are seen to condition network structure. Serious consideration of the larger macro-social context in which networks form and are sustained has been lacking in all but a small number of studies and is almost completely absent in studies of social network influences on health. We then move downstream to understand the influences network structure and function have on social and interpersonal behavior. We argue that networks operate at the behavioral level through four primary pathways: (1) provision of social support; (2) social influence; (3) on social engagement and attachment; and (4) access to resources and material goods.

  18. DASMiner: discovering and integrating data from DAS sources

    Directory of Open Access Journals (Sweden)

    Vasconcelos Ana

    2009-01-01

    Full Text Available Abstract Background DAS is a widely adopted protocol for providing syntactic interoperability among biological databases. The popularity of DAS is due to a simplified and elegant mechanism for data exchange that consists of sources exposing their RESTful interfaces for data access. As a growing number of DAS services are available for molecular biology resources, there is an incentive to explore this protocol in order to advance data discovery and integration among these resources. Results We developed DASMiner, a Matlab toolkit for querying DAS data sources that enables creation of integrated biological models using the information available in DAS-compliant repositories. DASMiner is composed by a browser application and an API that work together to facilitate gathering of data from different DAS sources, which can be used for creating enriched datasets from multiple sources. The browser is used to formulate queries and navigate data contained in DAS sources. Users can execute queries against these sources in an intuitive fashion, without the need of knowing the specific DAS syntax for the particular source. Using the source's metadata provided by the DAS Registry, the browser's layout adapts to expose only the set of commands and coordinate systems supported by the specific source. For this reason, the browser can interrogate any DAS source, independently of the type of data being served. The API component of DASMiner may be used for programmatic access of DAS sources by programs in Matlab. Once the desired data is found during navigation, the query is exported in the format of an API call to be used within any Matlab application. We illustrate the use of DASMiner by creating integrative models of histone modification maps and protein-protein interaction networks. These enriched datasets were built by retrieving and integrating distributed genomic and proteomic DAS sources using the API. Conclusion The support of the DAS protocol allows that

  19. Atomic-Level Sculpting of Crystalline Oxides: Toward Bulk Nanofabrication with Single Atomic Plane Precision.

    Science.gov (United States)

    Jesse, Stephen; He, Qian; Lupini, Andrew R; Leonard, Donovan N; Oxley, Mark P; Ovchinnikov, Oleg; Unocic, Raymond R; Tselev, Alexander; Fuentes-Cabrera, Miguel; Sumpter, Bobby G; Pennycook, Stephen J; Kalinin, Sergei V; Borisevich, Albina Y

    2015-11-25

    The atomic-level sculpting of 3D crystalline oxide nanostructures from metastable amorphous films in a scanning transmission electron microscope (STEM) is demonstrated. Strontium titanate nanostructures grow epitaxially from the crystalline substrate following the beam path. This method can be used for fabricating crystalline structures as small as 1-2 nm and the process can be observed in situ with atomic resolution. The fabrication of arbitrary shape structures via control of the position and scan speed of the electron beam is further demonstrated. Combined with broad availability of the atomic resolved electron microscopy platforms, these observations suggest the feasibility of large scale implementation of bulk atomic-level fabrication as a new enabling tool of nanoscience and technology, providing a bottom-up, atomic-level complement to 3D printing.

  20. Billiard simulation and FFT analysis of AAS oscillations in nanofabricated InGaAs

    Science.gov (United States)

    Koga, Takaaki; Faniel, Sebastien; Mineshige, Shunsuke; Matsuura, Toru; Sekine, Yoshiaki

    2010-03-01

    Gate-voltage-dependent amplitude of magneto-conductance oscillation was analyzed using FFT method. The obtained FFT spectrum was compared with the areal dependence of the occurrence and spin interferece amplitude, calculated for Altshuler-Aronov-Spivak (AAS) type time-reversal pairs of the interference paths on all possible classical trajectroies that were obtained by extensive billiard simulations within the given structures. We have calcuated generic spin interference (SI) curves as a function of the Rashba parameter α, for various values of the Dresselhaus parameter b41^6c6c [eVå^3]. The comparison between theory and experiment suggested that the value of b41^6c6c should be considerably reduced from 27 eVå^3, the generally known value from the k.p theory.

  1. Long Coherence Length 193 nm Laser for High-Resolution Nano-Fabrication

    Science.gov (United States)

    2008-06-27

    laser spectral bandwidth to coherence length and the measurement method used. A Michelson interferometer was used to directly measure the coherence...Using the SNLO non-linear optics modeling program and new fiber laser models both developed at Sandia National Labs, we were able to analyze pulsed and...scattering preclude pulsed fiber laser amplifiers from meeting our required power and coherence specifications. While CW fiber laser amplifiers are

  2. Integrability from 2d N=(2,2) Dualities

    CERN Document Server

    Yamazaki, Masahito

    2015-01-01

    We study integrable models in the context of the recently discovered Gauge/YBE correspondence, where the Yang-Baxter equation is promoted to a duality between two supersymmetric gauge theories. We study flavored elliptic genus of 2d $\\mathcal{N}=(2,2)$ quiver gauge theories, which theories are defined from statistical lattices regarded as quiver diagrams. Our R-matrices are written in terms of theta functions, and simplifies considerably when the gauge groups at the quiver nodes are Abelian. We also discuss the modularity properties of the R-matrix, reduction of 2d index to 1d Witten index, and string theory realizations of our theories.

  3. Observing integrals of heat kernels from a distance

    DEFF Research Database (Denmark)

    Heat kernels have integrals such as Brownian motion mean exit time, potential capacity, and torsional rigidity. We show how to obtain bounds on these values - essentially by observing their behaviour in terms of the distance function from a point and then comparing with corresponding values...... in tailor-made warped product spaces. The results will be illustrated by applications to the so-called 'type' problem: How to decide if a given manifold or surface is transient (hyperbolic) or recurrent (parabolic). Specific examples of minimal surfaces and constant pressure dry foams will be shown...

  4. Quantum field theory from operators to path integrals

    CERN Document Server

    Huang, Kerson

    1998-01-01

    A unique approach to quantum field theory, with emphasis on the principles of renormalization Quantum field theory is frequently approached from the perspective of particle physics. This book adopts a more general point of view and includes applications of condensed matter physics. Written by a highly respected writer and researcher, it first develops traditional concepts, including Feynman graphs, before moving on to key topics such as functional integrals, statistical mechanics, and Wilson's renormalization group. The connection between the latter and conventional perturbative renormalization is explained

  5. From experience to integration: the arts in nursing education.

    Science.gov (United States)

    McCaffrey, Ruth; Purnell, Marguerite

    2007-01-01

    Exploring the expressive arts within nursing education promotes understanding of what it means to be human and allows students to communicate with patients in unique and meaningful ways. "Arts in Healing," a three-credit elective course designed to provide experiences in creating and appreciating different art forms and to illuminate the healing elements in each, was offered in both the graduate and undergraduate nursing programs. Students at all levels, including pre-nursing, participated together. The article provides a course description and objectives and discusses implications for nurse educators. Examples of how nurses integrated what they learned from the course into their own practice are provided.

  6. From integrable models to gauge theories Festschrift Matinyan (Sergei G)

    CERN Document Server

    Gurzadyan, V G

    2002-01-01

    This collection of twenty articles in honor of the noted physicist and mentor Sergei Matinyan focuses on topics that are of fundamental importance to high-energy physics, field theory and cosmology. The topics range from integrable quantum field theories, three-dimensional Ising models, parton models and tests of the Standard Model, to black holes in loop quantum gravity, the cosmological constant and magnetic fields in cosmology. A pedagogical essay by Lev Okun concentrates on the problem of fundamental units. The articles have been written by well-known experts and are addressed to graduate

  7. Polymer Micro- and Nanofabrication for On-Chip Immune Cell Handling

    DEFF Research Database (Denmark)

    Hobæk, Thor Christian

    anti-mouse IgG showed similar affinity for mouse IgG in sandwich enzyme-linked immunosorbent assay (ELISA) as capture antibodies deposited by passive adsorption to bare thermoplastic replica. The transferred proteins were stable during incubation in serumcontaining cell medium for >1 week. Finally...... outside a CO2 cell incubator. Numerical simulations of oxygen transport were performed to establish guidelines for medium exchange rates in an impermeable culture system. Maturation of CD83+ mature DCs generated from CD14+ monocytes was demonstrated inside the disposable culture chip, with a yield almost......There is an increasing interest in combining micro- and nanotechnology with mass-fabrication techniques for clinical applications such as diagnostics and therapeutics. One of the most promising strategies for developing a cancer vaccine is immunotherapy based on dendritic cells (DCs). However...

  8. Information Systems Integration and Enterprise Application Integration (EAI) Adoption: A Case from Financial Services

    Science.gov (United States)

    Lam, Wing

    2007-01-01

    Increasingly, organizations find that they need to integrate large number of information systems in order to support enterprise-wide business initiatives such as e-business, supply chain management and customer relationship management. To date, organizations have largely tended to address information systems (IS) integration in an ad-hoc manner.…

  9. Information Systems Integration and Enterprise Application Integration (EAI) Adoption: A Case from Financial Services

    Science.gov (United States)

    Lam, Wing

    2007-01-01

    Increasingly, organizations find that they need to integrate large number of information systems in order to support enterprise-wide business initiatives such as e-business, supply chain management and customer relationship management. To date, organizations have largely tended to address information systems (IS) integration in an ad-hoc manner.…

  10. From Integrative to Game-Based Integrative Peer Response: High Ability versus Low Ability

    Science.gov (United States)

    Wang, J. H.; Chen, S. Y.; Chang, B.; Chan, T. W.

    2016-01-01

    Peer response is useful to improve student writing. However, traditional peer response takes a single mode, which has some problems, such as effort for preparation of documents or ambiguous feedback. To address these problems, this study presents two peer response approaches, that is, an integrative approach and a game-based integrative approach.…

  11. Nanofabrication Yields. Hybridization and Click-Fixation of Polycyclic DNA Nanoassemblies

    KAUST Repository

    Lundberg, Erik P.

    2011-09-27

    We demonstrate the stepwise assembly of a fully addressable polycyclic DNA hexagon nanonetwork for the preparation of a four-ring system, one of the biggest networks yet constructed from tripodal building blocks. We find that the yield exhibits a distinct upper level <100%, a fundamental problem of thermodynamic DNA assembly that appears to have been overlooked in the DNA nanotechnology literature. A simplistic model based on a single step-yield parameter y can quantitatively describe the total yield of DNA assemblies in one-pot reactions as Y = yduplex n, with n the number of hybridization steps. Experimental errors introducing deviations from perfect stoichiometry and the thermodynamics of hybridization equilibria contribute to decreasing the value of yduplex (on average y = 0.96 for our 10 base pair hybridization). For the four-ring system (n = 31), the total yield is thus less than 30%, which is clearly unsatisfactory if bigger nanoconstructs of this class are to be designed. Therefore, we introduced site-specific click chemistry for making and purifying robust building blocks for future modular constructs of larger assemblies. Although the present yield of this robust module was only about 10%, it demonstrates a first step toward a general fabrication approach. Interestingly, we find that the click yields follow quantitatively a binomial distribution, the predictability of which indicates the usefulness of preparing pools of pure and robust building blocks in this way. The binomial behavior indicates that there is no interference between the six simultaneous click reactions but that step-yield limiting factors such as topological constraints and Cu(I) catalyst concentration are local and independent. © 2011 American Chemical Society.

  12. Advanced Nanofabrication Process Development for Self-Powered System-on-Chip

    KAUST Repository

    Rojas, Jhonathan Prieto

    2010-11-01

    In this work the development of a Self-Powered System-On-Chip is explored by examining two components of process development in different perspectives. On one side, an energy component is approached from a biochemical standpoint where a Microbial Fuel Cell (MFC) is built with standard microfabrication techniques, displaying a novel electrode based on Carbon Nanotubes (CNTs). The fabrication process involves the formation of a micrometric chamber that hosts an enhanced CNT-based anode. Preliminary results are promising, showing a high current density (113.6mA/m2) compared with other similar cells. Nevertheless many improvements can be done to the main design and further characterization of the anode will give a more complete understanding and bring the device closer to a practical implementation. On a second point of view, nano-patterning through silicon nitride spacer width control is developed, aimed at producing alternative sub-100nm device fabrication with the potential of further scaling thanks to nanowire based structures. These nanostructures are formed from a nano-pattern template, by using a bottom-up fabrication scheme. Uniformity and scalability of the process are demonstrated and its potential described. An estimated area of 0.120μm2 for a 6T-SRAM (Static Random Access Memory) bitcell (6 devices) can be achieved. In summary, by using a novel sustainable energy component and scalable nano-patterning for logic and computing module, this work has successfully collected the essential base knowledge and joined two different elements that synergistically will contribute for the future implementation of a Self-Powered System-on-Chip.

  13. NanoLiterBioReactor: long-term mammalian cell culture at nanofabricated scale.

    Science.gov (United States)

    Prokop, Ales; Prokop, Zdenka; Schaffer, David; Kozlov, Eugene; Wikswo, John; Cliffel, David; Baudenbacher, Franz

    2004-12-01

    There is a need for microminiaturized cell-culture environments, i.e. NanoLiter BioReactors (NBRs), for growing and maintaining populations of up to several hundred cultured mammalian cells in volumes three orders of magnitude smaller than those contained in standard multi-well screening plates. These devices would enable the development of a new class of miniature, automated cell-based bioanalysis arrays for monitoring the immediate environment of multiple cell lines and assessing the effects of drug or toxin exposure. We fabricated NBR prototypes, each of which incorporates a culture chamber, inlet and outlet ports, and connecting microfluidic conduits. The fluidic components were molded in polydimethylsiloxane (PDMS) using soft-lithography techniques, and sealed via plasma activation against a glass slide, which served as the primary culture substrate in the NBR. The input and outlet ports were punched into the PDMS block, and enabled the supply and withdrawal of culture medium into/from the culture chamber (10-100 nL volume), as well as cell seeding. Because of the intrinsically high oxygen permeability of the PDMS material, no additional CO(2)/air supply was necessary. The developmental process for the NBR typically employed several iterations of the following steps: Conceptual design, mask generation, photolithography, soft lithography, and proof-of-concept culture assay. We have arrived at several intermediate designs. One is termed "circular NBR with a central post (CP-NBR)," another, "perfusion (grid) NBR (PG-NBR)," and a third version, "multitrap (cage) NBR (MT-NBR)," the last two providing total cell retention. Three cells lines were tested in detail: a fibroblast cell line, CHO cells, and hepatocytes. Prior to the culturing trials, extensive biocompatibility tests were performed on all materials to be employed in the NBR design. To delineate the effect of cell seeding density on cell viability and survival, we conducted separate plating experiments

  14. NASICs: A 'fabric-centric' approach towards integrated nanosystems

    Science.gov (United States)

    Narayanan, Pritish

    This dissertation addresses the fundamental problem of how to build computing systems for the nanoscale. With CMOS reaching fundamental limits, emerging nanomaterials such as semiconductor nanowires, carbon nanotubes, graphene etc. have been proposed as promising alternatives. However, nanoelectronics research has largely focused on a 'device-first' mindset without adequately addressing system-level capabilities, challenges for integration and scalable assembly. In this dissertation, we propose to develop an integrated nano-fabric, (broadly defined as nanostructures/devices in conjunction with paradigms for assembly, interconnection and circuit styles), as opposed to approaches that focus on MOSFET replacement devices as the ultimate goal. In the 'fabric-centric' mindset, design choices at individual levels are made compatible with the fabric as a whole and minimize challenges for nanomanufacturing while achieving system-level benefits vs. scaled CMOS. We present semiconductor nanowire based nano-fabrics incorporating these fabric-centric principles called NASICs and N3ASICs and discuss how we have taken them from initial design to experimental prototype. Manufacturing challenges are mitigated through careful design choices at multiple levels of abstraction. Regular fabrics with limited customization mitigate overlay alignment requirements. Cross-nanowire FET devices and interconnect are assembled together as part of the uniform regular fabric without the need for arbitrary fine-grain interconnection at the nanoscale, routing or device sizing. Unconventional circuit styles are devised that are compatible with regular fabric layouts and eliminate the requirement for using complementary devices. Core fabric concepts are introduced and validated. Detailed analyses on device-circuit co-design and optimization, cascading, noise and parameter variation are presented. Benchmarking of nanowire processor designs vs. equivalent scaled 16nm CMOS shows up to 22X area, 30X

  15. Nanofabrication of gate-defined GaAs/AlGaAs lateral quantum dots.

    Science.gov (United States)

    Bureau-Oxton, Chloé; Camirand Lemyre, Julien; Pioro-Ladrière, Michel

    2013-11-01

    A quantum computer is a computer composed of quantum bits (qubits) that takes advantage of quantum effects, such as superposition of states and entanglement, to solve certain problems exponentially faster than with the best known algorithms on a classical computer. Gate-defined lateral quantum dots on GaAs/AlGaAs are one of many avenues explored for the implementation of a qubit. When properly fabricated, such a device is able to trap a small number of electrons in a certain region of space. The spin states of these electrons can then be used to implement the logical 0 and 1 of the quantum bit. Given the nanometer scale of these quantum dots, cleanroom facilities offering specialized equipment- such as scanning electron microscopes and e-beam evaporators- are required for their fabrication. Great care must be taken throughout the fabrication process to maintain cleanliness of the sample surface and to avoid damaging the fragile gates of the structure. This paper presents the detailed fabrication protocol of gate-defined lateral quantum dots from the wafer to a working device. Characterization methods and representative results are also briefly discussed. Although this paper concentrates on double quantum dots, the fabrication process remains the same for single or triple dots or even arrays of quantum dots. Moreover, the protocol can be adapted to fabricate lateral quantum dots on other substrates, such as Si/SiGe.

  16. Nanofabrication and characterization of PVA-organofiller/Ag nanocoatings on pMAD plasmids

    Science.gov (United States)

    Erdonmez, D.; Mosayyebi, S.; Erkan, K.; Salimi, K.; Nagizade, N.; Saglam, N.; Rzayev, Z. M. O.

    2014-11-01

    Nowadays, the most important problem in microbial researches is bacterial resistance which is carried out by DNA plasmids against antibacterial agents. The effect of antibacterial nanoparticles on bacteria is remarkable, but studies on the interactions of these particles with plasmids do not search or there are no adequate studies. We proposed that the nanoparticles, which are disrupted the self-assembled structure of plasmids, may decrease the resistance of bacteria, and therefore, increase the activity of utilized antibacterial agents. In this work, we synthesized polymer nanofiber webs samples by electrospinning technique from pure water solution of nanocomposites with different contents of silver nanoparticles, and surface morphology of nanofibers composites were characterized by SEM microscopy. Their interactions with pMAD DNA plasmids were investigated. It was demonstrated that the synthesized Ag-carrying nanohybrid composites with higher surface contacted areas were significantly inhibited the activity of plasmid DNA against bacterial resistance. Agreeing with obtained results, synthesized nanofiber coatings can be recommended for the widely applications in nanobiotechnology, nanomedicine, and bioengineering processing.

  17. Nanofabrication at 1nm resolution by quantum optical lithography (Presentation Recording)

    Science.gov (United States)

    Pavel, Eugen

    2015-08-01

    A major problem in the optical lithography was the diffraction limit. Here, we report and demonstrate a lithography method, Quantum Optical Lithography [1,2], able to attain 1 nm resolution by optical means using new materials (fluorescent photosensitive glass-ceramics and QMC-5 resist). The performance is several times better than that described for any optical or Electron Beam Lithography (EBL) methods. In Fig. 1 we present TEM images of 1 nm lines recorded at 9.6 m/s. a) b) Fig. 1 TEM images of: a) multiple 1 nm lines written in a fluorescent photosensitive glass-ceramics sample; b) single 1 nm line written in QMC-5 resist. References [1] E. Pavel, S. Jinga, B.S. Vasile, A. Dinescu, V. Marinescu, R. Trusca and N. Tosa, "Quantum Optical Lithography from 1 nm resolution to pattern transfer on silicon wafer", Optics and Laser Technology, 60 (2014) 80-84. [2] E. Pavel, S. Jinga, E. Andronescu, B.S. Vasile, G. Kada, A. Sasahara, N. Tosa, A. Matei, M. Dinescu, A. Dinescu and O.R. Vasile, "2 nm Quantum Optical Lithography", Optics Communications,291 (2013) 259-263

  18. Quantifying chaotic dynamics from integrate-and-fire processes

    Energy Technology Data Exchange (ETDEWEB)

    Pavlov, A. N. [Department of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov (Russian Federation); Saratov State Technical University, Politehnicheskaya Str. 77, 410054 Saratov (Russian Federation); Pavlova, O. N. [Department of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov (Russian Federation); Mohammad, Y. K. [Department of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov (Russian Federation); Tikrit University Salahudin, Tikrit Qadisiyah, University Str. P.O. Box 42, Tikrit (Iraq); Kurths, J. [Potsdam Institute for Climate Impact Research, Telegraphenberg A 31, 14473 Potsdam (Germany); Institute of Physics, Humboldt University Berlin, 12489 Berlin (Germany)

    2015-01-15

    Characterizing chaotic dynamics from integrate-and-fire (IF) interspike intervals (ISIs) is relatively easy performed at high firing rates. When the firing rate is low, a correct estimation of Lyapunov exponents (LEs) describing dynamical features of complex oscillations reflected in the IF ISI sequences becomes more complicated. In this work we discuss peculiarities and limitations of quantifying chaotic dynamics from IF point processes. We consider main factors leading to underestimated LEs and demonstrate a way of improving numerical determining of LEs from IF ISI sequences. We show that estimations of the two largest LEs can be performed using around 400 mean periods of chaotic oscillations in the regime of phase-coherent chaos. Application to real data is discussed.

  19. Crowding is unlike ordinary masking: distinguishing feature integration from detection.

    Science.gov (United States)

    Pelli, Denis G; Palomares, Melanie; Majaj, Najib J

    2004-12-30

    A letter in the peripheral visual field is much harder to identify in the presence of nearby letters. This is "crowding." Both crowding and ordinary masking are special cases of "masking," which, in general, refers to any effect of a "mask" pattern on the discriminability of a signal. Here we characterize crowding, and propose a diagnostic test to distinguish it from ordinary masking. In ordinary masking, the signal disappears. In crowding, it remains visible, but is ambiguous, jumbled with its neighbors. Masks are usually effective only if they overlap the signal, but the crowding effect extends over a large region. The width of that region is proportional to signal eccentricity from the fovea and independent of signal size, mask size, mask contrast, signal and mask font, and number of masks. At 4 deg eccentricity, the threshold contrast for identification of a 0.32 deg signal letter is elevated (up to six-fold) by mask letters anywhere in a 2.3 deg region, 7 times wider than the signal. In ordinary masking, threshold contrast rises as a power function of mask contrast, with a shallow log-log slope of 0.5 to 1, whereas, in crowding, threshold is a sigmoidal function of mask contrast, with a steep log-log slope of 2 at close spacing. Most remarkably, although the threshold elevation decreases exponentially with spacing, the threshold and saturation contrasts of crowding are independent of spacing. Finally, ordinary masking is similar for detection and identification, but crowding occurs only for identification, not detection. More precisely, crowding occurs only in tasks that cannot be done based on a single detection by coarsely coded feature detectors. These results (and observers' introspections) suggest that ordinary masking blocks feature detection, so the signal disappears, while crowding (like "illusory conjunction") is excessive feature integration - detected features are integrated over an inappropriately large area because there are no smaller integration

  20. [From virtue bioethics to bioethics personalistic: is integration possible?].

    Science.gov (United States)

    Pastor, Luis Miguel

    2013-01-01

    In this article we analyze how the idea of virtue as an important element of human ethical action is slowly being lost. There are proposals both in ethics and in bioethics to rehabilitate virtue and to consider it as a very important element of human morality. In particular, in the health sector the rehabilitation of virtue, would imply greater focus on the ethical character of professionals and personal improvement rather than on training for the resolution of ethical cases. Such guidance would also improve the health professional-patient relationship with an increase not only in the technical quality but also in human dimension of health sciences. However, this orientation or tendency in bioethics suffers from a deficit in reasoning due to lack of a complete theory of human action that covers the good and also norms. The second part of the article looks at the relation between of virtue and personalistic bioethics. Virtue is considered as an important element of human action and is integrated with the good and norms. After analyzing and distinguishing between what is today considered personalistic bioethics and the contributions of personalism to bioethics, the paper concludes that the integration of virtue in personalistic bioethics is not only possible but desirable to overcome the ethical minimalism that has resulted from modern day principlism driven bioethics.

  1. Integration in urban climate adaptation: Lessons from Rotterdam on integration between scientific disciplines and integration between scientific and stakeholder knowledge

    NARCIS (Netherlands)

    Groot, A.M.E.; Bosch, P.R.; Buijs, S.; Jacobs, C.M.J.; Moors, E.J.

    2015-01-01

    Based on the experience acquired in the Bergpolder Zuid district in the city of Rotterdam, The Netherlands, this paper presents lessons learned so far on science-policy interactions supporting the adaptation to climate change in an urban district. Two types of integration issues were considered: (1)

  2. Integrals of $K$ and $E$ from Lattice Sums

    OpenAIRE

    J. G. WAN; Zucker, I. J.

    2014-01-01

    We give closed form evaluations for many families of integrals, whose integrands contain algebraic functions of the complete elliptic integrals $K$ and $E$. Our methods exploit the rich structures connecting complete elliptic integrals, Jacobi theta functions, lattice sums, and Eisenstein series. Various examples are given, and along the way new (including 10-dimensional) lattice sum evaluations are produced.

  3. Pathogenesis and prediction of diabetes mellitus: lessons from integrative physiology.

    Science.gov (United States)

    Bergman, Richard N

    2002-10-01

    The molecular revolution in biology is providing an exponentially increasing body of data regarding subcellular events in normal and pathological conditions. The task of integrating even a small part of this deluge of information is a formidable challenge. Many integrative regulatory principles are still unknown. The present article argues that important principles may be discovered by the repetitive experimental testing of simple isomorphic computer or mathematical models of biological regulation. The system regulating the blood glucose is used as an example. Implicit in a minimal model, postulated more than 20 years ago, were specific but untested assumptions. These assumptions, which were tested over the ensuing decades, have enriched our understanding of metabolic regulation and the causes of diabetes. Currently accepted concepts emerging from modeling include: (a) the importance of sluggish insulin transport across the capillary endothelium in stimulation of glucose uptake; (b) the single gateway concept, that insulin transport across endothelium of adipose tissue suppresses free fatty acids, which act in turn to reduce endogenous glucose production by the liver; (c) the importance of the single gateway mechanism in the metabolic syndrome, whereby increased fat in the abdominal compartment relates to insulin resistance and risk for type 2 diabetes; and (d) the hyperbolic relationship between insulin action and insulin secretion, which provides an accurate prediction of diabetes risk. It is hoped that the experience with the metabolic system will provide a metaphor for other regulatory systems less subjected to critical quantitative analysis. Such analysis may well lead to analogous conceptual understanding of other important integrated biological systems, and provide approaches for early intervention in the pathogenic process of other chronic and devastating diseases.

  4. Development and Integration of a Pulsed 2-micron Direct Detection Integrated Path Differential Absorption (IPDA) Lidar for CO2 Column Measurement from Airborne platform Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Develop, integrate and demonstrate a 2-micron pulsed Integrated Path Differential Absorption Lidar (IPDA) instrument CO2 Column Measurement from Airborne platform...

  5. Nanofabrication in Polymer Solutions

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    This review covers recent advances in fabrication of nanomaterials in polymersolutions with emphasis on using the self-assembled amphiphilic block copolymers in solutionto fabricate organic/inorganic composites with nanoscale modifications. The phase behaviorof block copolymers in water and the use of templates to form ordered nanostructures arereviewed in detail. Modern physical techniques for nanoscale characterization are alsointroduced. The authors suggested that this approach should provide new routes to creatematerials with interesting morphologies for many different applications.

  6. Supercapacitive Iontronic Nanofabric Sensing.

    Science.gov (United States)

    Li, Ruya; Si, Yang; Zhu, Zijie; Guo, Yaojun; Zhang, Yingjie; Pan, Ning; Sun, Gang; Pan, Tingrui

    2017-07-31

    The study of wearable devices has become a popular research topic recently, where high-sensitivity, noise proof sensing mechanisms with long-term wearability play critical roles in a real-world implementation, while the existing mechanical sensing technologies (i.e., resistive, capacitive, or piezoelectric) have yet offered a satisfactory solution to address them all. Here, we successfully introduced a flexible supercapacitive sensing modality to all-fabric materials for wearable pressure and force sensing using an elastic ionic-electronic interface. Notably, an electrospun ionic fabric utilizing nanofibrous structures offers an extraordinarily high pressure-to-capacitance sensitivity (114 nF kPa(-1) ), which is at least 1000 times higher than any existing capacitive sensors and one order of magnitude higher than the previously reported ionic devices, with a pressure resolution of 2.4 Pa, achieving high levels of noise immunity and signal stability for wearable applications. In addition, its fabrication process is fully compatible with existing industrial manufacturing and can lead to cost-effective production for its utility in emerging wearable uses in a foreseeable future. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Algebraic reconstruction of piecewise-smooth functions from integral measurements

    CERN Document Server

    Batenkov, Dmitry; Yomdin, Yosef

    2011-01-01

    This paper presents some results on a well-known problem in Algebraic Signal Sampling and in other areas of applied mathematics: reconstruction of piecewise-smooth functions from their integral measurements (like moments, Fourier coefficients, Radon transform, etc.). Our results concern reconstruction (from the moments or Fourier coefficients) of signals in two specific classes: linear combinations of shifts of a given function, and "piecewise $D$-finite functions" which satisfy on each continuity interval a linear differential equation with polynomial coefficients. In each case the problem is reduced to a solution of a certain type of non-linear algebraic system of equations ("Prony-type system"). We recall some known methods for explicitly solving such systems in one variable, and provide extensions to some multi-dimensional cases. Finally, we investigate the local stability of solving the Prony-type systems.

  8. Lessons learned from CIRFT testing on SNF vibration integrity study

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Jy-An John [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wang, Hong [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Jiang, Hao [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bevard, Bruce Balkcom [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Howard, Rob L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Scaglione, John M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-01-01

    A cyclic integrated reversible-bending fatigue tester (CIRFT) was developed to support U.S. NRC and DOE Used Fuel Disposition Campaign studies on high burn-up (HBU) spent nuclear fuel (SNF) transportation during normal conditions of transport (NCT). Two devices were developed; the first CIRFT was successfully installed and operated in the ORNL hot-cells in September 2013. Since hot cell testing commenced several HBU SNF samples from both Zr-4 and M5 clads were investigated. The second CIRFT device was developed in February 2014, and has been used to test clad/fuel surrogate rods (stainless steel with alumina pellet inserts). The second CIRFT machine has also been used for sensor development and test sensitivity analyses, as well as loading boundary condition parameter studies. The lessons learned from CIRFT testing will be presented in this paper.

  9. Discrete Integrable Systems and Poisson Algebras From Cluster Maps

    Science.gov (United States)

    Fordy, Allan P.; Hone, Andrew

    2014-01-01

    We consider nonlinear recurrences generated from cluster mutations applied to quivers that have the property of being cluster mutation-periodic with period 1. Such quivers were completely classified by Fordy and Marsh, who characterised them in terms of the skew-symmetric matrix that defines the quiver. The associated nonlinear recurrences are equivalent to birational maps, and we explain how these maps can be endowed with an invariant Poisson bracket and/or presymplectic structure. Upon applying the algebraic entropy test, we are led to a series of conjectures which imply that the entropy of the cluster maps can be determined from their tropical analogues, which leads to a sharp classification result. Only four special families of these maps should have zero entropy. These families are examined in detail, with many explicit examples given, and we show how they lead to discrete dynamics that is integrable in the Liouville-Arnold sense.

  10. Understanding Organizational Memory from the Integrated Management Systems (ERP

    Directory of Open Access Journals (Sweden)

    Gilberto Perez

    2013-10-01

    Full Text Available With this research, in the form of a theoretical essay addressing the theme of Organizational Memory and Integrated Management Systems (ERP, we tried to present some evidence of how this type of system can contribute to the consolidation of certain features of Organizational Memory. From a theoretical review of the concepts of Human Memory, extending to the Organizational Memory and Information Systems, with emphasis on Integrated Management Systems (ERP we tried to draw a parallel between the functions and structures of Organizational Memory and features and characteristics of ERPs. The choice of the ERP system for this study was made due to the complexity and broad scope of this system. It was verified that the ERPs adequately support many functions of the Organizational Memory, highlighting the implementation of logical processes, practices and rules in business. It is hoped that the dialogue presented here can contribute to the advancement of the understanding of organizational memory, since the similarity of Human Memory is a fertile field and there is still much to be researched.

  11. Quantum Field Theory: From Operators to Path Integrals

    Science.gov (United States)

    Huang, Kerson

    1998-07-01

    A unique approach to quantum field theory, with emphasis on the principles of renormalization Quantum field theory is frequently approached from the perspective of particle physics. This book adopts a more general point of view and includes applications of condensed matter physics. Written by a highly respected writer and researcher, it first develops traditional concepts, including Feynman graphs, before moving on to key topics such as functional integrals, statistical mechanics, and Wilson's renormalization group. The connection between the latter and conventional perturbative renormalization is explained. Quantum Field Theory is an exceptional textbook for graduate students familiar with advanced quantum mechanics as well as physicists with an interest in theoretical physics. It features: * Coverage of quantum electrodynamics with practical calculations and a discussion of perturbative renormalization * A discussion of the Feynman path integrals and a host of current subjects, including the physical approach to renormalization, spontaneous symmetry breaking and superfluidity, and topological excitations * Nineteen self-contained chapters with exercises, supplemented with graphs and charts

  12. Reexamination of molecular integrals arising from the Dirac equation. Analytical evaluation of molecular auxiliary functions integrals

    OpenAIRE

    Bagci, A.

    2016-01-01

    In this work, analytical solutions to relativistic molecular integrals are proposed for use in ab-initio molecular electronic structure calculations. They are expressed through molecular auxiliary functions integrals in prolate spheroidal coordinates. Recurrence relations and new convergent series representation formulae are derived. They involve Slater-type orbitals basis set with non-integer principal quantum numbers. The comparison is made with the benchmark results of use numerical global...

  13. 45 CFR 61.12 - Requesting information from the Healthcare Integrity and Protection Data Bank.

    Science.gov (United States)

    2010-10-01

    ... Integrity and Protection Data Bank. 61.12 Section 61.12 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION HEALTHCARE INTEGRITY AND PROTECTION DATA BANK FOR FINAL ADVERSE INFORMATION... Integrity and Protection Data Bank § 61.12 Requesting information from the Healthcare Integrity...

  14. The Glory Program: Global Science from a Unique Spacecraft Integration

    Science.gov (United States)

    Bajpayee Jaya; Durham, Darcie; Ichkawich, Thomas

    2006-01-01

    The Glory program is an Earth and Solar science mission designed to broaden science community knowledge of the environment. The causes and effects of global warming have become a concern in recent years and Glory aims to contribute to the knowledge base of the science community. Glory is designed for two functions: one is solar viewing to monitor the total solar irradiance and the other is observing the Earth s atmosphere for aerosol composition. The former is done with an active cavity radiometer, while the latter is accomplished with an aerosol polarimeter sensor to discern atmospheric particles. The Glory program is managed by NASA Goddard Space Flight Center (GSFC) with Orbital Sciences in Dulles, VA as the prime contractor for the spacecraft bus, mission operations, and ground system. This paper will describe some of the more unique features of the Glory program including the integration and testing of the satellite and instruments as well as the science data processing. The spacecraft integration and test approach requires extensive analysis and additional planning to ensure existing components are successfully functioning with the new Glory components. The science mission data analysis requires development of mission unique processing systems and algorithms. Science data analysis and distribution will utilize our national assets at the Goddard Institute for Space Studies (GISS) and the University of Colorado's Laboratory for Atmospheric and Space Physics (LASP). The Satellite was originally designed and built for the Vegetation Canopy Lidar (VCL) mission, which was terminated in the middle of integration and testing due to payload development issues. The bus was then placed in secure storage in 2001 and removed from an environmentally controlled container in late 2003 to be refurbished to meet the Glory program requirements. Functional testing of all the components was done as a system at the start of the program, very different from a traditional program

  15. Spin diffusion from an inhomogeneous quench in an integrable system

    Science.gov (United States)

    Ljubotina, Marko; Žnidarič, Marko; Prosen, Tomaž

    2017-07-01

    Generalized hydrodynamics predicts universal ballistic transport in integrable lattice systems when prepared in generic inhomogeneous initial states. However, the ballistic contribution to transport can vanish in systems with additional discrete symmetries. Here we perform large scale numerical simulations of spin dynamics in the anisotropic Heisenberg XXZ spin 1/2 chain starting from an inhomogeneous mixed initial state which is symmetric with respect to a combination of spin reversal and spatial reflection. In the isotropic and easy-axis regimes we find non-ballistic spin transport which we analyse in detail in terms of scaling exponents of the transported magnetization and scaling profiles of the spin density. While in the easy-axis regime we find accurate evidence of normal diffusion, the spin transport in the isotropic case is clearly super-diffusive, with the scaling exponent very close to 2/3, but with universal scaling dynamics which obeys the diffusion equation in nonlinearly scaled time.

  16. Spectral Duality in Integrable Systems from AGT Conjecture

    CERN Document Server

    Mironov, A; Zenkevich, Y; Zotov, A

    2012-01-01

    We describe relationships between integrable systems with N degrees of freedom arising from the AGT conjecture. Namely, we prove the equivalence (spectral duality) between the N-cite Heisenberg spin chain and a reduced gl(N) Gaudin model both at classical and quantum level. The former one appears on the gauge theory side of the AGT relation in the Nekrasov-Shatashvili (and further the Seiberg-Witten) limit while the latter one is natural on the CFT side. At the classical level, the duality transformation relates the Seiberg-Witten differentials and spectral curves via a bispectral involution. The quantum duality extends this to the equivalence of the corresponding Baxter-Schrodinger equations (quantum spectral curves). This equivalence generalizes both the spectral self-duality between the 2x2 and NxN representations of the Toda chain and the famous AHH duality.

  17. Fast Escape from Quantum Mazes in Integrated Photonics

    CERN Document Server

    Caruso, Filippo; Ciriolo, Anna Gabriella; Sciarrino, Fabio; Osellame, Roberto

    2015-01-01

    Escaping from a complex maze, by exploring different paths with several decision-making branches in order to reach the exit, has always been a very challenging and fascinating task. Wave field and quantum objects may explore a complex structure in parallel by interference effects, but without necessarily leading to more efficient transport. Here, inspired by recent observations in biological energy transport phenomena, we demonstrate how a quantum walker can efficiently reach the output of a maze by partially suppressing the presence of interference. In particular, we show theoretically an unprecedented improvement in transport efficiency for increasing maze size with respect to purely quantum and classical approaches. In addition, we investigate experimentally these hybrid transport phenomena, by mapping the maze problem in an integrated waveguide array, probed by coherent light, hence successfully testing our theoretical results. These achievements may lead towards future bio-inspired photonics technologies...

  18. Spacelab - From early integration to first flight. I

    Science.gov (United States)

    Thirkettle, A.; di Mauro, F.; Stephens, R.

    1984-05-01

    Spacelab is a series of flight elements that can be assembled together in different configurations. The laboratory is designed to accommodate many payloads with totally different characteristics. Two models were built: one was tested functionally, integrated into an Engineering Model and delivered to NASA. The other was used for subsystem testing. The Spacelab system consists of several functional elements within the Module, Igloo and Pallet structures: an Electric Power Distribution Subsystem, a Command and Data Management Subsystem, Software, Caution-and-Warning Subsystem and an Environmental Control Subsystem. The Engineering Model tests were conducted in Europe from April 1978 through October 1980, delivery of the laboratory to JFK Space Center, Florida was in December 1980, and the first flight was made in November 1983 on Space Shuttle STS-9.

  19. Integrated flash flood vulnerability assessment: Insights from East Attica, Greece

    Science.gov (United States)

    Karagiorgos, Konstantinos; Thaler, Thomas; Heiser, Micha; Hübl, Johannes; Fuchs, Sven

    2016-10-01

    In the framework of flood risk assessment, vulnerability is a key concept to assess the susceptibility of elements at risk. Besides the increasing amount of studies on flash floods available, in-depth information on vulnerability in Mediterranean countries was missing so far. Moreover, current approaches in vulnerability research are driven by a divide between social scientists who tend to view vulnerability as representing a set of socio-economic factors, and natural scientists who view vulnerability in terms of the degree of loss to an element at risk. Further, vulnerability studies in response to flash flood processes are rarely answered in the literature. In order to close this gap, this paper implemented an integrated vulnerability approach focusing on residential buildings exposed to flash floods in Greece. In general, both physical and social vulnerability was comparable low, which is interpreted as a result from (a) specific building regulations in Greece as well as general design principles leading to less structural susceptibility of elements at risk exposed, and (b) relatively low economic losses leading to less social vulnerability of citizens exposed. The population show high risk awareness and coping capacity to response to natural hazards event and in the same time the impact of the events are quite low, because of the already high use of local protection measures. The low vulnerability score for East Attica can be attributed especially to the low physical vulnerability and the moderate socio-economic well-being of the area. The consequence is to focus risk management strategies mainly in the reduction of the social vulnerability. By analysing both physical and social vulnerability an attempt was made to bridge the gap between scholars from sciences and humanities, and to integrate the results of the analysis into the broader vulnerability context.

  20. Meat science: From proteomics to integrated omics towards system biology.

    Science.gov (United States)

    D'Alessandro, Angelo; Zolla, Lello

    2013-01-14

    Since the main ultimate goal of farm animal raising is the production of proteins for human consumption, research tools to investigate proteins play a major role in farm animal and meat science. Indeed, proteomics has been applied to the field of farm animal science to monitor in vivo performances of livestock animals (growth performances, fertility, milk quality etc.), but also to further our understanding of the molecular processes at the basis of meat quality, which are largely dependent on the post mortem biochemistry of the muscle, often in a species-specific way. Post mortem alterations to the muscle proteome reflect the biological complexity of the process of "muscle to meat conversion," a process that, despite decades of advancements, is all but fully understood. This is mainly due to the enormous amounts of variables affecting meat tenderness per se, including biological factors, such as animal species, breed specific-characteristic, muscle under investigation. However, it is rapidly emerging that the tender meat phenotype is not only tied to genetics (livestock breeding selection), but also to extrinsic factors, such as the rearing environment, feeding conditions, physical activity, administration of hormonal growth promotants, pre-slaughter handling and stress, post mortem handling. From this intricate scenario, biochemical approaches and systems-wide integrated investigations (metabolomics, transcriptomics, interactomics, phosphoproteomics, mathematical modeling), which have emerged as complementary tools to proteomics, have helped establishing a few milestones in our understanding of the events leading from muscle to meat conversion. The growing integration of omics disciplines in the field of systems biology will soon contribute to take further steps forward.

  1. Genic insights from integrated human proteomics in GeneCards.

    Science.gov (United States)

    Fishilevich, Simon; Zimmerman, Shahar; Kohn, Asher; Iny Stein, Tsippi; Olender, Tsviya; Kolker, Eugene; Safran, Marilyn; Lancet, Doron

    2016-01-01

    GeneCards is a one-stop shop for searchable human gene annotations (http://www.genecards.org/). Data are automatically mined from ∼120 sources and presented in an integrated web card for every human gene. We report the application of recent advances in proteomics to enhance gene annotation and classification in GeneCards. First, we constructed the Human Integrated Protein Expression Database (HIPED), a unified database of protein abundance in human tissues, based on the publically available mass spectrometry (MS)-based proteomics sources ProteomicsDB, Multi-Omics Profiling Expression Database, Protein Abundance Across Organisms and The MaxQuant DataBase. The integrated database, residing within GeneCards, compares favourably with its individual sources, covering nearly 90% of human protein-coding genes. For gene annotation and comparisons, we first defined a protein expression vector for each gene, based on normalized abundances in 69 normal human tissues. This vector is portrayed in the GeneCards expression section as a bar graph, allowing visual inspection and comparison. These data are juxtaposed with transcriptome bar graphs. Using the protein expression vectors, we further defined a pairwise metric that helps assess expression-based pairwise proximity. This new metric for finding functional partners complements eight others, including sharing of pathways, gene ontology (GO) terms and domains, implemented in the GeneCards Suite. In parallel, we calculated proteome-based differential expression, highlighting a subset of tissues that overexpress a gene and subserving gene classification. This textual annotation allows users of VarElect, the suite's next-generation phenotyper, to more effectively discover causative disease variants. Finally, we define the protein-RNA expression ratio and correlation as yet another attribute of every gene in each tissue, adding further annotative information. The results constitute a significant enhancement of several Gene

  2. Flow units from integrated WFT and NMR data

    Energy Technology Data Exchange (ETDEWEB)

    Kasap, E.; Altunbay, M.; Georgi, D.

    1997-08-01

    Reliable and continuous permeability profiles are vital as both hard and soft data required for delineating reservoir architecture. They can improve the vertical resolution of seismic data, well-to-well stratigraphic correlations, and kriging between the well locations. In conditional simulations, permeability profiles are imposed as the conditioning data. Variograms, covariance functions and other geostatistical indicators are more reliable when based on good quality permeability data. Nuclear Magnetic Resonance (NMR) logging and Wireline Formation Tests (WFT) separately generate a wealth of information, and their synthesis extends the value of this information further by providing continuous and accurate permeability profiles without increasing the cost. NMR and WFT data present a unique combination because WFTs provide discrete, in situ permeability based on fluid-flow, whilst NMR responds to the fluids in the pore space and yields effective porosity, pore-size distribution, bound and moveable fluid saturations, and permeability. The NMR permeability is derived from the T{sub 2}-distribution data. Several equations have been proposed to transform T{sub 2} data to permeability. Regardless of the transform model used, the NMR-derived permeabilities depend on interpretation parameters that may be rock specific. The objective of this study is to integrate WFT permeabilities with NMR-derived, T{sub 2} distribution-based permeabilities and thereby arrive at core quality, continuously measured permeability profiles. We outlined the procedures to integrate NMR and WFT data and applied the procedure to a field case. Finally, this study advocates the use of hydraulic unit concepts to extend the WFT-NMR derived, core quality permeabilities to uncored intervals or uncored wells.

  3. Optimizing Computation of Repairs from Active Integrity Constraints

    DEFF Research Database (Denmark)

    Cruz-Filipe, Luís

    2014-01-01

    Active integrity constraints (AICs) are a form of integrity constraints for databases that not only identify inconsistencies, but also suggest how these can be overcome. The semantics for AICs defines different types of repairs, but deciding whether an inconsistent database can be repaired...

  4. Alkane production from biomass: chemo-, bio- and integrated catalytic approaches.

    Science.gov (United States)

    Deneyer, Aron; Renders, Tom; Van Aelst, Joost; Van den Bosch, Sander; Gabriëls, Dries; Sels, Bert F

    2015-12-01

    Linear, branched and cyclic alkanes are important intermediates and end products of the chemical industry and are nowadays mainly obtained from fossil resources. In search for alternatives, biomass feedstocks are often presented as a renewable carbon source for the production of fuels, chemicals and materials. However, providing a complete market for all these applications seems unrealistic due to both financial and logistic issues. Despite the very large scale of current alkane-based fuel applications, biomass definitely has the potential to offer a partial solution to the fuel business. For the smaller market of chemicals and materials, a transition to biomass as main carbon source is more realistic and even probably unavoidable in the long term. The appropriate use and further development of integrated chemo- and biotechnological (catalytic) process strategies will be crucial to successfully accomplish this petro-to-bio feedstock transition. Furthermore, a selection of the most promising technologies from the available chemo- and biocatalytic tool box is presented. New opportunities will certainly arise when multidisciplinary approaches are further explored in the future. In an attempt to select the most appropriate biomass sources for each specific alkane-based application, a diagram inspired by van Krevelen is applied, taking into account both the C-number and the relative functionality of the product molecules.

  5. Consumer exposure to phthalates from paper packaging: an integrated approach.

    Science.gov (United States)

    Poças, M F; Oliveira, J C; Pereira, J R; Hogg, T

    2010-10-01

    This paper presents an integrated approach to estimate the exposure of the Portuguese population to phthalates as a contaminant originating from paperboard packaging. The approach combined data of migrant concentration in the foods resulting from a stochastic simulation with consumption data of food packaged in paperboard. The results from the exposure model were validated with experimental values actually found in the food. A short surveillance exercise was conducted with samples collection from market shelves to identify and quantify the phthalates present in both the packages and the food. The distribution of values for the di-butyl phthalate concentration in the packages was used as the input of the initial concentration in the Weibull model to estimate the concentration of this phthalate in the foods. This distribution of occurrence data was then combined with the packaging usage data in a probabilistic simulation with a Monte Carlo sampling method. Exposure values ranged between zero and 8.95 microg day(-1) kg(bw), a value close to the tolerable daily intake established by the European Food Safety Authority (EFSA)--10 microg day(-1) kg(bw). However, the 97.5th percentile and the average were 1.82 and 0.44 day(-1) kg(bw), respectively, indicating that further refinement of the estimates is not necessary. Other phthalates were also detected in the packaging samples: di-isobutyl phthalate and di-ethylhexyl phthalate. The latter was present in all packaging samples collected and was detected in a few food samples at values requiring further investigation.

  6. ATLAS from Data Research Associates: A Fully Integrated Automation System.

    Science.gov (United States)

    Mellinger, Michael J.

    1987-01-01

    This detailed description of a fully integrated, turnkey library system includes a complete profile of the system (functions, operational characteristics, hardware, operating system, minimum memory and pricing); history of the technologies involved; and descriptions of customer services and availability. (CLB)

  7. TESTING STOCK MARKETS’ INTEGRATION FROM CENTRAL AND EASTERN EUROPEAN COUNTRIES WITHIN EURO ZONE

    Directory of Open Access Journals (Sweden)

    Viorica CHIRILA

    2014-10-01

    Full Text Available Stock market integration gives the opportunity of risk diversification on international level. The main effects of this integration are the development of stock markets and economic growth. This paper analyses the integration of stock markets from Central and Eastern Europe using convergence. Beta-convergence gives us information about integration’s speed and sigma-convergence presents information about the degree of integration of stock markets from Central and Eastern Europe on the stock market of Euro Zone.

  8. Integrated results from the COPERNICUS and GALILEO studies.

    Science.gov (United States)

    Pielen, Amelie; Clark, W Lloyd; Boyer, David S; Ogura, Yuichiro; Holz, Frank G; Korobelnik, Jean-Francois; Stemper, Brigitte; Asmus, Friedrich; Rittenhouse, Kay D; Ahlers, Christiane; Vitti, Robert; Saroj, Namrata; Zeitz, Oliver; Haller, Julia A

    2017-01-01

    To report on the efficacy and safety of intravitreal aflibercept in patients with macular edema secondary to central retinal vein occlusion (CRVO) in an integrated analysis of COPERNICUS and GALILEO. Patients were randomized to receive intravitreal aflibercept 2 mg every 4 weeks or sham injections until week 24. From week 24 to week 52, all intravitreal aflibercept-treated patients in both studies and sham-treated patients in COPERNICUS were eligible to receive intravitreal aflibercept based on prespecified criteria. In GALILEO, sham-treated patients continued to receive sham treatment through week 52. At week 24, mean gain in best-corrected visual acuity and mean reduction in central retinal thickness were greater for intravitreal aflibercept-treated patients compared with sham, consistent with individual trial results. At week 52, after 6 months of intravitreal aflibercept as-needed treatment in COPERNICUS, patients originally randomized to sham group experienced visual and anatomic improvements but did not improve to the extent of those initially treated with intravitreal aflibercept, while the sham group in GALILEO did not improve over week 24 mean best-corrected visual acuity scores. Ocular serious adverse events occurred in COPERNICUS and GALILEO confirmed that intravitreal aflibercept is an effective treatment for macular edema following CRVO.

  9. Audiovisual integration of emotional signals from others’ social interactions.

    Directory of Open Access Journals (Sweden)

    Lukasz ePiwek

    2015-05-01

    Full Text Available Audiovisual perception of emotions has been typically examined using displays of a solitary character (e.g. the face-voice and/or body-sound of one actor. However, in real life humans often face more complex multisensory social situations, involving more than one person. Here we ask if the audiovisual facilitation in emotion recognition previously found in simpler social situations extends to more complex and ecological situations. Stimuli consisting of the biological motion and voice of two interacting agents were used in two experiments. In Experiment 1, participants were presented with visual, auditory, auditory filtered/noisy, and audiovisual congruent and incongruent clips. We asked participants to judge whether the two agents were interacting happily or angrily. In Experiment 2, another group of participants repeated the same task, as in Experiment 1, while trying to ignore either the visual or the auditory information. The findings from both experiments indicate that when the reliability of the auditory cue was decreased participants weighted more the visual cue in their emotional judgments. This in turn translated in increased emotion recognition accuracy for the multisensory condition. Our findings thus point to a common mechanism of multisensory integration of emotional signals irrespective of social stimulus complexity.

  10. Integration models in health information systems: experiences from the PlugIT project.

    Science.gov (United States)

    Mykkänen, Juha; Porrasmaa, Jari; Korpela, Mikko; Häkkinen, Heidi; Toivanen, Marika; Tuomainen, Mika; Häyrinen, Kristiina; Rannanheimo, Juha

    2004-01-01

    Different approaches are available for the integration of existing health information systems (HIS) in integration projects. Within the PlugIT project in Finland, we have found it necessary to design and implement integration in a collaborative, multidisciplinary and open way. In this paper, we use some generic integration models and relate them to the methods, solutions and experiences of the project. We summarize the results from nine integration teams, methods development and supporting surveys and studies, and discuss these experiences to provide some guidelines for the HIS integration projects in general.

  11. Integrated protection from prevalent wheat parasites in semiarid region

    Directory of Open Access Journals (Sweden)

    Jerković Zoran J.

    2013-01-01

    Full Text Available This paper is aimed at presenting contemporary knowledge in the field of integral wheat protection against parasites, i.e. the use of cultural measures and genetic analyses directed at adequate use of breeding results, monitoring and forecasting of prevalent parasite growth and development with the aim of rational fungicide application. In addition, the paper suggests the proper use of biological measures through artificial infection with Pyrenophora tritici repentis (Ptr in years not favourable for facultative parasite development. Growing of the varieties not lower than 85 cm with optimal stem growth ratio in regions with 550-650 mm precipitation, deep and complete soil cultivation plus nutrition before sowing in late October reduced the risk of facultative parasite appearance on lower and middle leaves by over 15%, which was considered useful because of the antagonism to obligate parasites. Severity of Puccinia triticina on last two leaves when facultative parasites were absent was increased at 60-70% as maximal level according to suggested SAGR. Nevertheless, we suggest growing of varieties with prolonged latency period resistant to Puccinia triticina. The aim is to avoid overaccumulation of resistance genes consequential through the decrease of wheat grain yielding potential. Genes facilitating toxin from Ptr spreading have to be excluded because of necessary antagonistic effect from the middle leaves. This implies gene for the obligate parasite specific resistance diversity of varieties in order to reduce the probability of simultaneous overcoming of resistance and avoid insurmountable changes in seed production. The final result of the proposed system should be the last two leaves with mostly minimal parasite appearance and the possibility of economical and efficient single curative treatment application once in ten years when facultative parasites are absent in spring or after the resistance of variety is overcome in standard conditions

  12. The Integrated Medical Model: Outcomes from Independent Review

    Science.gov (United States)

    Myers, J.; Garcia, Y.; Griffin, D.; Arellano, J.; Boley, L.; Goodenow, D. A.; Kerstman, E.; Reyes, D.; Saile, L.; Walton, M.; hide

    2017-01-01

    In 2016, the Integrated Medical Model (IMM) v4.0 underwent an extensive external review in preparation for transition to an operational status. In order to insure impartiality of the review process, the Exploration Medical Capabilities Element of NASA's Human Research Program convened the review through the Systems Review Office at NASA Goddard Space Flight Center (GSFC). The review board convened by GSFC consisted of persons from both NASA and academia with expertise in the fields of statistics, epidemiology, modeling, software development, aerospace medicine, and project management (see Figure 1). The board reviewed software and code standards, as well as evidence pedigree associated with both the input and outcomes information. The board also assesses the models verification, validation, sensitivity to parameters and ability to answer operational questions. This talk will discuss the processes for designing the review, how the review progressed and the findings from the board, as well as summarize the IMM project responses to those findings. Overall, the board found that the IMM is scientifically sound, represents a necessary, comprehensive approach to identifying medical and environmental risks facing astronauts in long duration missions and is an excellent tool for communication between engineers and physicians. The board also found IMM and its customer(s) should convene an additional review of the IMM data sources and to develop a sustainable approach to augment, peer review, and maintain the information utilized in the IMM. The board found this is critically important because medical knowledge continues to evolve. Delivery of IMM v4.0 to the Crew Health and Safety (CHS) Program will occur in the 2017. Once delivered for operational decision support, IMM v4.0 will provide CHS with additional quantitative capability in to assess astronaut medical risks and required medical capabilities to help drive down overall mission risks.

  13. Templates for integrated nanofiber growth

    DEFF Research Database (Denmark)

    Oliveira Hansen, Roana Melina de

    Para-hexaphenylene (p6P) molecules have the ability to self-assemble into organic nanofibers. These nanofibers hold unique optoelectronic properties, which make them interesting candidates as elements in electronic and optoelectronic devices. Typically these nanofibers are grown on specific single......, high-volume integration. Besides such single-crystalline templates, the nanofibers can also be grown on non-crystalline gold surfaces, on which the orientation of the nanofibers can be manipulated by structuring the gold surface prior to p6P deposition. In this work, a novel method for in-situ growth...... of p6P nanofibers on nano-structured gold surfaces is presented. The substrates are prepared by conventional nanofabrication techniques such as e-beam lithography and metal deposition, which increase their potential as device platforms. Some of the results presented here demonstrate, that both...

  14. PARTICIPATION AND INTEGRATION FROM THE PERSPECTIVE OF PERSONS WITH SPINAL CORD INJURY FROM FIVE EUROPEAN COUNTRIES

    NARCIS (Netherlands)

    Ruoranen, Kaisa; Post, Marcel W. M.; Juvalta, Sibylle; Reinhardt, Jan D.

    2015-01-01

    Objective: To examine the subjective understanding of participation and integration of persons with spinal cord injuries from 5 European countries and to compare these findings with the International Classification of Functioning, Disability and Health (ICF)'s conceptualization of participation. Met

  15. The Integrated Design Process from the Facilitator's Perspective

    Science.gov (United States)

    Lee, Jeehyun

    2014-01-01

    The focus of this study was to clarify the integrated design process from an educational standpoint, and identify its influencing factors and the role of facilitator. Through a literature review, the integrated design process and the role of facilitator were framed, and through the case study, the whole process of integrated design and the…

  16. HURWITZ-HODGE INTEGRAL IDENTITIES FROM THE ORBIFOLD MARI(N)O-VAFA FORMULA

    Institute of Scientific and Technical Information of China (English)

    Chen ZHAO

    2016-01-01

    In this paper, we present some polynomial identities of Hurwitz-Hodge integral. Subsequently, we present how to obtain some Hurwitz-Hodge integral identities from the poly-nomial identity. Lastly, we give a recursion formula for Hurwitz-Hodge integral 〈τbLλgλ1〉aq.

  17. INTEGRAL reports renewed activity from KS 1741-293

    DEFF Research Database (Denmark)

    Chenevez, Jérôme; Kuulkers, E.; Alfonso-Garzón, J.

    2010-01-01

    The low-mass X-ray binary and burster source KS 1741-293 has been detected during recent INTEGRAL Galactic bulge (see ATel #438) observations by the JEM-X instrument. On February 25, 2010, between UTC 13:04 and 14:08, KS 1741-293 was detected at a 3-10 keV flux of 9 +/- 4 mCrab, and an upper limit...... in the same energy bands. The region will be observed again by INTEGRAL on March 10, and the regular INTEGRAL monitoring of the Galactic bulge will continue until April 17, 2010. We encourage follow-up observations of this source at all wavelengths....

  18. INTEGRAL reports renewed activity from KS 1741-293

    DEFF Research Database (Denmark)

    Chenevez, Jérôme; Kuulkers, E.; Alfonso-Garzón, J.;

    2010-01-01

    The low-mass X-ray binary and burster source KS 1741-293 has been detected during recent INTEGRAL Galactic bulge (see ATel #438) observations by the JEM-X instrument. On February 25, 2010, between UTC 13:04 and 14:08, KS 1741-293 was detected at a 3-10 keV flux of 9 +/- 4 mCrab, and an upper limi...... in the same energy bands. The region will be observed again by INTEGRAL on March 10, and the regular INTEGRAL monitoring of the Galactic bulge will continue until April 17, 2010. We encourage follow-up observations of this source at all wavelengths....

  19. OzFlux data: network integration from collection to curation

    Science.gov (United States)

    Isaac, Peter; Cleverly, James; McHugh, Ian; van Gorsel, Eva; Ewenz, Cacilia; Beringer, Jason

    2017-06-01

    Measurement of the exchange of energy and mass between the surface and the atmospheric boundary-layer by the eddy covariance technique has undergone great change in the last 2 decades. Early studies of these exchanges were confined to brief field campaigns in carefully controlled conditions followed by months of data analysis. Current practice is to run tower-based eddy covariance systems continuously over several years due to the need for continuous monitoring as part of a global effort to develop local-, regional-, continental- and global-scale budgets of carbon, water and energy. Efficient methods of processing the increased quantities of data are needed to maximise the time available for analysis and interpretation. Standardised methods are needed to remove differences in data processing as possible contributors to observed spatial variability. Furthermore, public availability of these data sets assists with undertaking global research efforts. The OzFlux data path has been developed (i) to provide a standard set of quality control and post-processing tools across the network, thereby facilitating inter-site integration and spatial comparisons; (ii) to increase the time available to researchers for analysis and interpretation by reducing the time spent collecting and processing data; (iii) to propagate both data and metadata to the final product; and (iv) to facilitate the use of the OzFlux data by adopting a standard file format and making the data available from web-based portals. Discovery of the OzFlux data set is facilitated through incorporation in FLUXNET data syntheses and the publication of collection metadata via the RIF-CS format. This paper serves two purposes. The first is to describe the data sets, along with their quality control and post-processing, for the other papers of this Special Issue. The second is to provide an example of one solution to the data collection and curation challenges that are encountered by similar flux tower networks

  20. Integrated bioethanol and biomanure production from potato waste.

    Science.gov (United States)

    Chintagunta, Anjani Devi; Jacob, Samuel; Banerjee, Rintu

    2016-03-01

    Disposal of potato processing waste and the problem of pollution associated with it is a vital issue that is being faced by the potato processing plants. The conventional peeling methods presently followed in the processing plants for removing the potato peel, also result in the loss of some portion of the mash which is rich in starch. Indiscriminate discharge of the waste causes detrimental effects in the environment, so this problem can be resolved by successful utilization of the waste for the generation of value added products. Hence, the present work focuses on integrated production of bioethanol and biomanure to utilize the waste completely leading to zero waste generation. The first part of the work describes a comparative study of ethanol production from potato peel and mash wastes by employing co-culture of Aspergillus niger and Saccharomyces cerevisiae at various incubation time (24-120 h) instead of application of enzymes. The solid state fermentation of potato peel and mash inoculated with co-culture, resulted in bioethanol production of 6.18% (v/v) and 9.30% (v/v) respectively. In the second part of the work, the residue obtained after ethanol production was inoculated with seven different microorganisms (Nostoc muscorum, Fischerella muscicola, Anabaena variabilis, Aulosira fertilissima, Cylindrospermum muscicola, Azospirillium lipoferum, Azotobacter chroococcum) and mixture of all the organisms in equal ratio for nitrogen (N), phosphorous (P) and potassium (K) enrichment. Among them, A. variabilis was found to enrich N, P and K content of the residue by nearly 7.66, 21.66 and 15 fold than that of the initial content, ultimately leading to improved N:P:K ratio of approximately 2:1:1. The application of simultaneous saccharification and fermentation (SSF) for the conversion of potato waste to ethanol and enrichment of residue obtained after ethanol production with microorganisms to be used as manure envisages environmental sustainability.

  1. Integrating Data from Geological Investigations into Urban Watershed Restoration Efforts

    Science.gov (United States)

    Kaufman, M.; Rogers, D.; Murray, K.

    2012-04-01

    To improve urban watershed restoration efforts, a framework for integrating the outputs from subsurface geological investigations into land use planning is developed. This framework synthesizes the data generated at the individual parcel scale, including a full inventory of water flows on the surface and within the subsurface, and the synergy between contaminant properties and the geological environment. Using a case study approach, over 3000 sites of environmental contamination were investigated in the heavily urbanized Rouge River watershed of southeastern Michigan, USA. Analysis of the remediation costs at these contaminated sites and the patterns of groundwater contamination strongly suggest that land use planning in this region has not incorporated the basic sciences of geology and geomorphology. At a broad geographical scale, the siting of cities near flowing water and their industries above vulnerable geology resulted in large extents of contamination that are costly to remediate. This historical process was complicated by the unplanned nature of urban sprawl, as industrial sites were located in areas of high groundwater vulnerability, and their spatial juxtaposition created unintended consequences by expanding the pathways for contamination transport. To help remedy this situation, it is recommended that urban watershed restoration efforts include groundwater vulnerability studies, and these studies should become a basic component of the land use planning process, much as environmental site assessments are for the real estate industry. Moreover, through source control, the parcel scale is where science-based landscape planning can most effectively aid in urban watershed restoration efforts and prevent further environmental damage to land being considered for new development or redevelopment.

  2. Total Correlation Function Integrals and Isothermal Compressibilities from Molecular Simulations

    DEFF Research Database (Denmark)

    Wedberg, Rasmus; Peters, Günther H.j.; Abildskov, Jens

    2008-01-01

    Generation of thermodynamic data, here compressed liquid density and isothermal compressibility data, using molecular dynamics simulations is investigated. Five normal alkane systems are simulated at three different state points. We compare two main approaches to isothermal compressibilities: (1...... in approximately the same amount of time. This suggests that computation of total correlation function integrals is a route to isothermal compressibility, as accurate and fast as well-established benchmark techniques. A crucial step is the integration of the radial distribution function. To obtain sensible results...

  3. From colleague to patient: ethical challenges in integrated primary care.

    Science.gov (United States)

    Kanzler, Kathryn E; Goodie, Jeffrey L; Hunter, Christopher L; Glotfelter, Michael Ann; Bodart, Jennifer J

    2013-03-01

    Ethical codes and guidelines for mental health professionals focus on traditional avenues of practice, leaving considerable gaps for clinicians in unique settings, such as behavioral health providers in integrated primary care. In this article, an ethical scenario is presented, where a behavioral health provider is faced with a colleague physician seeking assistance for emotional distress. The scenario highlights important ethical questions about multiple relationships/conflict of interest, impaired colleagues, informed consent, and confidentiality. We review gaps in ethical guidance pertinent to the scenario and provide an eight-step rubric for ethical clinical decision making in integrated primary care.

  4. From su(2 Gaudin Models to Integrable Tops

    Directory of Open Access Journals (Sweden)

    Matteo Petrera

    2007-04-01

    Full Text Available In the present paper we derive two well-known integrable cases of rigid body dynamics (the Lagrange top and the Clebsch system performing an algebraic contraction on the two-body Lax matrices governing the (classical su(2 Gaudin models. The procedure preserves the linear r-matrix formulation of the ancestor models. We give the Lax representation of the resulting integrable systems in terms of su(2 Lax matrices with rational and elliptic dependencies on the spectral parameter. We finally give some results about the many-body extensions of the constructed systems.

  5. Microsystem integration from RF to millimeter wave applications

    Science.gov (United States)

    Vähä-Heikkilä, T.; Lahti, M.

    2015-05-01

    Radio frequency systems have been applied successfully to consumer products. Typically these radios operate up to 6 GHz. During recent years, interest towards microwave (up to 30 GHz) and millimeter wave frequencies (30 ... 300 GHz) has increased significantly. Technologies have been developed to have high performance microwave and millimeter wave components. On the other hand, integration and packaging technologies have not developed as fast while their importance is crucial especially in consumer applications. This presentation focuses to latest trends in wireless microsystem component integration and packaging trends backed up with demonstrators and measured results based on VTT's demonstrations.

  6. Recent advances in nanoplasmonic biosensors: applications and lab-on-a-chip integration

    Science.gov (United States)

    Lopez, Gerardo A.; Estevez, M.-Carmen; Soler, Maria; Lechuga, Laura M.

    2017-01-01

    Motivated by the recent progress in the nanofabrication field and the increasing demand for cost-effective, portable, and easy-to-use point-of-care platforms, localized surface plasmon resonance (LSPR) biosensors have been subjected to a great scientific interest in the last few years. The progress observed in the research of this nanoplasmonic technology is remarkable not only from a nanostructure fabrication point of view but also in the complete development and integration of operative devices and their application. The potential benefits that LSPR biosensors can offer, such as sensor miniaturization, multiplexing opportunities, and enhanced performances, have quickly positioned them as an interesting candidate in the design of lab-on-a-chip (LOC) optical biosensor platforms. This review covers specifically the most significant achievements that occurred in recent years towards the integration of this technology in compact devices, with views of obtaining LOC devices. We also discuss the most relevant examples of the use of the nanoplasmonic biosensors for real bioanalytical and clinical applications from assay development and validation to the identification of the implications, requirements, and challenges to be surpassed to achieve fully operative devices.

  7. Recent advances in nanoplasmonic biosensors: applications and lab-on-a-chip integration

    Directory of Open Access Journals (Sweden)

    Lopez Gerardo A.

    2016-08-01

    Full Text Available Motivated by the recent progress in the nanofabrication field and the increasing demand for cost-effective, portable, and easy-to-use point-of-care platforms, localized surface plasmon resonance (LSPR biosensors have been subjected to a great scientific interest in the last few years. The progress observed in the research of this nanoplasmonic technology is remarkable not only from a nanostructure fabrication point of view but also in the complete development and integration of operative devices and their application. The potential benefits that LSPR biosensors can offer, such as sensor miniaturization, multiplexing opportunities, and enhanced performances, have quickly positioned them as an interesting candidate in the design of lab-on-a-chip (LOC optical biosensor platforms. This review covers specifically the most significant achievements that occurred in recent years towards the integration of this technology in compact devices, with views of obtaining LOC devices. We also discuss the most relevant examples of the use of the nanoplasmonic biosensors for real bioanalytical and clinical applications from assay development and validation to the identification of the implications, requirements, and challenges to be surpassed to achieve fully operative devices.

  8. The integration of immigrants

    OpenAIRE

    Bauböck, Rainer

    1995-01-01

    from the Table of Contents: Migration and integration - Basic concepts and definitions; Immigration and Integration policies; The legal framework for integration; Dimension of social integration; Cultural integration; Conclusions;

  9. INTEGRAL spots renewed activity from H1743-322

    DEFF Research Database (Denmark)

    Kuulkers, E.; Brandt, Søren Kristian; Budtz-Jørgensen, Carl;

    2008-01-01

    INTEGRAL Galactic Bulge monitoring (see ATels #438, #874, #1005, #1385) observations on UT 2008 Sep 23 08:51-12:34 reveal a new outburst of the Galactic black-hole candidate and X-ray transient H1743-322/IGR J17464-3213 (see ATels #132, #136, #576, #593, #1348, #1385, #1414). JEM-X and IBIS...

  10. Human Processing of Knowledge from Texts: Acquisition, Integration, and Reasoning

    Science.gov (United States)

    1979-06-01

    and shared schema. The concepts labeled ~i’ Person i, and ~i represent placeholders, or slots, that are associated with (i.e., bind ) different...Educational Psychology, 1975, 67, 445-450. Garrod, S. and Sanford, A. Interpreting anaphoric relations: The integration of semantic information while reading

  11. From integral manifolds and metrics to potential maps

    Directory of Open Access Journals (Sweden)

    Udriste, C

    2004-01-01

    Full Text Available Our paper contains two main results: (1 the integral manifolds of a distribution together with two Riemann metrics produce potential maps which are in fact least squares approximations of the starting integral manifolds; (2 the least squares energy admits extremals satisfying periodic boundary conditions. Section 1 contains historical and bibliographical notes. Section 2 analyses some elements of the geometry produced on the jet bundle of order one by a semi-Riemann Sasaki-like metric. Section 3 describes the maximal integral manifolds of a distribution as solutions of a PDEs system of order one. Section 4 studies Poisson-like second-order prolongations of first order PDE systems and formulates the Lorentz-Udriste World-Force Law on a suitable semi-Riemann-Lagrange manifold (the base manifold of the jet bundle of order one. Section 5 exploits the idea of least squares Lagrangians, to include the integral manifolds of a distribution into a class of extremals. Section 6 gives conditions for the existence of extremals in conditions of multi-periodicity. Section 7 refers to the canonical forms of the vertical metric d-tensor produced by a density of energy on jet bundle of order one.

  12. INTEGRAL spots renewed activity from H1743-322

    DEFF Research Database (Denmark)

    Kuulkers, E.; Brandt, Søren Kristian; Budtz-Jørgensen, Carl

    2008-01-01

    INTEGRAL Galactic Bulge monitoring (see ATels #438, #874, #1005, #1385) observations on UT 2008 Sep 23 08:51-12:34 reveal a new outburst of the Galactic black-hole candidate and X-ray transient H1743-322/IGR J17464-3213 (see ATels #132, #136, #576, #593, #1348, #1385, #1414). JEM-X and IBIS...

  13. From Knowledge Theory to Management Practice: Towards an Integrated Approach.

    Science.gov (United States)

    Shin, Minsoo; Holden, Tony; Schmidt, Ruth A.

    2001-01-01

    Critically contrasts the three main schools of thought on knowledge and assesses the resulting implications for knowledge management. Presents a conceptual model to integrate theoretical and practical themes to serve as a framework for developing a future research agenda for the development of knowledge management business tools and applications.…

  14. Historical Business Cycles and Market Integration: Evidence from Comovement

    NARCIS (Netherlands)

    Uebele, Martin

    2009-01-01

    This thesis addresses historical business cycles and market integration in Europe and America in the 19th and 20th centuries. For the analysis of historical business cycles, the widely used methodology of historical national accounting is complemented with a dynamic factor model that allows for usin

  15. THE NEW YEAR MESSAGE FROM CHINESE JOURNAL OF INTEGRATIVE MEDICINE

    Institute of Scientific and Technical Information of China (English)

    陈可冀

    2003-01-01

    @@ Two months into the year 2003 and one month into the Chinese lunar New Year of goat, on behalf of the editorial board of the Chinese Journal of Integrative Medicine, I wish our readers, contributors and board members around the world a prosperous and successful new year.

  16. Lessons from Large-Scale Renewable Energy Integration Studies: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Bird, L.; Milligan, M.

    2012-06-01

    In general, large-scale integration studies in Europe and the United States find that high penetrations of renewable generation are technically feasible with operational changes and increased access to transmission. This paper describes other key findings such as the need for fast markets, large balancing areas, system flexibility, and the use of advanced forecasting.

  17. An Integrated Library System from Existing Microcomputer Programs.

    Science.gov (United States)

    Kuntz, Lynda S.

    1988-01-01

    Demonstrates how three commercial microcomputer software packages--PC-Talk III, Wordstar, and dBase III--were combined to produce an integrated library system at the U.S. Army Concepts Analysis Agency library. The retrospective conversion process is discussed, and the four modules of the system are described: acquisitions/cataloging; online…

  18. LS/2000--The Integrated Library System from OCLC.

    Science.gov (United States)

    Olson, Susan

    1984-01-01

    Discusses design features of the Online Catalog of LS/2000, OCLC's enhanced version of Integrated Library System. This minicomputer-based system provides bibliographic file maintenance, circulation control, and online catalog searching. Examples of available displays--holdings, full MARC, work forms, keyword entry, index selection, brief citation,…

  19. Historical Business Cycles and Market Integration: Evidence from Comovement

    NARCIS (Netherlands)

    Uebele, Martin

    2009-01-01

    This thesis addresses historical business cycles and market integration in Europe and America in the 19th and 20th centuries. For the analysis of historical business cycles, the widely used methodology of historical national accounting is complemented with a dynamic factor model that allows for

  20. 18Regional integration and social cohesion: Perspectives from the ...

    African Journals Online (AJOL)

    between social cohesion and regional integration in the developing world. Candice ... of public policy, and the EU even prioritises the EU Social Cohesion Funds in its .... networks of ethnic entrepreneurs and grassroots non-state actors. ... definitions and issues', Paper SRA-309, Strategic Research and Analysis Directorate,.

  1. First results from the INTEGRAL galactic plane scans

    DEFF Research Database (Denmark)

    Winkler, C.; Gehrels, N.; Schonfelder, V.

    2003-01-01

    Scans of the Galactic plane performed at regular intervals constitute a key element of the guaranteed time observations of the INTEGRAL observing programme. These scans are done for two reasons: frequent monitoring of the Galactic plane in order to detect transient sources, and time resolved...

  2. The Value of ERP Curriculum Integration: Perspectives from the Research

    Science.gov (United States)

    Hepner, Michelle; Dickson, Warren

    2013-01-01

    In the current economic conditions, many institutions face dwindling budgets and an increased focus on proving the value of the education provided. The effort and costs required to integrate Enterprise Resource Planning systems into course curricula are a significant investment of resources for any university. This paper examines the expense of…

  3. Integrating HIV prevention and treatment: from slogans to impact.

    Directory of Open Access Journals (Sweden)

    Joshua A Salomon

    2005-01-01

    in the long term. In the various scenarios the numbers of people being treated in 2020 ranges from 9.2 million in a treatment-only scenario with mixed effects, to 4.2 million in a combined response scenario with positive treatment-prevention synergies. CONCLUSIONS: These analyses demonstrate the importance of integrating expanded care activities with prevention activities if there are to be long-term reductions in the number of new HIV infections and significant declines in AIDS mortality. Treatment can enable more effective prevention, and prevention makes treatment affordable. Sustained progress in the global fight against HIV/AIDS will be attained only through a comprehensive response.

  4. Integrative mental health care: from theory to practice, Part 2.

    Science.gov (United States)

    Lake, James

    2008-01-01

    Integrative approaches will lead to more accurate and different understandings of mental illness. Beneficial responses to complementary and alternative therapies provide important clues about the phenomenal nature of the human body in space-time and disparate biological, informational, and energetic factors associated with normal and abnormal psychological functioning. The conceptual framework of contemporary Western psychiatry includes multiple theoretical viewpoints, and there is no single best explanatory model of mental illness. Future theories of mental illness causation will not depend exclusively on empirical verification of strictly biological processes but will take into account both classically described biological processes and non-classical models, including complexity theory, resulting in more complete explanations of the characteristics and causes of symptoms and mechanisms of action that result in beneficial responses to treatments. Part 1 of this article examined the limitations of the theory and contemporary clinical methods employed in Western psychiatry and discussed implications of emerging paradigms in physics and the biological sciences for the future of psychiatry. In part 2, a practical methodology, for planning integrative assessment and treatment strategies in mental health care is proposed. Using this methodology the integrative management of moderate and severe psychiatric symptoms is reviewed in detail. As the conceptual framework of Western medicine evolves toward an increasingly integrative perspective, novel understanding of complex relationships between biological, informational, and energetic processes associated with normal psychological functioning and mental illness will lead to more effective integrative assessment and treatment strategies addressing the causes or meanings of symptoms at multiple hierarchic levels of body-brain-mind.

  5. Integrative mental health care: from theory to practice, part 1.

    Science.gov (United States)

    Lake, James

    2007-01-01

    Integrative approaches will lead to more accurate and different understandings of mental illness. Beneficial responses to complementary and alternative therapies provide important clues about the phenomenal nature of the human body in space-time and disparate biological, informational, and energetic factors associated with normal and abnormal psychological functioning. The conceptual framework of contemporary Western psychiatry includes multiple theoretical viewpoints, and there is no single best explanatory model of mental illness. Future theories of mental illness causation will not depend exclusively on empirical verification of strictly biological processes but will take into account both classically described biological processes and non-classical models, including complexity theory, resulting in more complete explanations of the characteristics and causes of symptoms and mechanisms of action that result in beneficial responses to treatments. Part 1 of this article examines the limitations of the theory and contemporary clinical methods employed in Western psychiatry and discusses implications of emerging paradigms in physics and the biological sciences for the future of psychiatry. In part 2, a practical methodology for planning integrative assessment and treatment strategies in mental health care is proposed. Using this methodology the integrative management of moderate and severe psychiatric symptoms is reviewed in detail. As the conceptual framework of Western medicine evolves toward an increasingly integrative perspective, novel understandings of complex relationships between biological, informational, and energetic processes associated with normal psychological functioning and mental illness will lead to more effective integrative assessment and treatment strategies addressing the causes or meanings of symptoms at multiple hierarchic levels of body-brain-mind.

  6. Integration, Configuration and Coordination: from Project to Reality, at CERN

    CERN Document Server

    Barberan Marin, Maria; Bernardini, Marzia; Birtwistle, Thomas; Chemli, Samy; Corso, Jean-Pierre; Coupard, Julie; Foraz, Katy; Grillot, Serge; Muttoni, Yvon; Perrot, Anne-Laure

    2016-01-01

    The rigorous process in place at CERN to approve and follow-up the implementation of any modification of the LHC machine and its Injectors is presented in this paper. Our methodology implies the support of three teams, in charge of the configuration management, the scheduling and safety coordination, and the 3D integration studies. At each stage of the project the support of the three teams evolves, to provide the adequate support in the preparation phase and during the technical stops and long shutdowns. The formal roles and the processes used to govern the interaction of the Integration, Configuration and Coordination teams, and their relation to the project teams during the preparation and implementation phases, for activities to be performed in LHC and its injector chain are described and discussed.

  7. Planning for Integrated Transport in Indonesia: Some Lessons from the UK’s Experience

    Directory of Open Access Journals (Sweden)

    Yos Sunitiyoso

    2012-01-01

    Full Text Available Traffic congestion has been a major problem in many cities in Indonesia, thus requiring abetter transport policy. Many developed countries, including the United Kingdom, has beenimplementing the integrated transport policy to replace traditional transport policy that focuson only building roads to anticipate traffic demand. This paper provides a highlight on theimplementation of integrated transport policy in the United Kingdom. Some key issues thatcan be learnt by the Indonesian government from their experience are discussed. This includesthe integration within and between all types of transport, integration with land use planning,integration with environment policy and integration with policies for education, health andwealth creations. In the implementation, the policy requires continuity and stability inorganization and politics, coordination in local transport plans, more devolution on powerand revenue funding from the government in addition to capital funding.Key words: traffic congestion, integrated transport policy

  8. From NHS Choices to the integrated customer service platform.

    Science.gov (United States)

    Gann, Bob; Grant, Maria J

    2013-03-01

    In 2013 the NHS Commissioning Board launches its new integrated customer service platform. The new service utilises the full range of channels (web, telephone, apps etc) to provide access to information to support transparency, participation and transactions. Digital health services have proven benefits in informed choice, shared decision making and patient participation. © 2013 The authors. Health Information and Libraries Journal © 2013 Health Libraries Group.

  9. Accuracy of Star Cluster Parameters from Integrated UBVRI Photometry

    CERN Document Server

    Narbutis, D; Stonkute, R; Vansevicius, V

    2007-01-01

    We study the capability of the UBVRI photometric system to quantify star clusters in terms of age, metallicity, and color excess by their integrated photometry. The well known age-metallicity-extinction degeneracy was analyzed for various parameter combinations, assuming different levels of photometric accuracy. We conclude that the UBVRI photometric system enables us to estimate star cluster parameters over a wide range, if the overall photometric accuracy is better than ~0.03 mag.

  10. Integrated Defense: Lessons Learned from Joint Base Balad

    Science.gov (United States)

    2013-01-01

    integrator (BOS-I) for Joint Base Balad (JBB)—formerly known as Logis- tics Support Area (LSA) Anaconda and Balad Air Base. This gave the Air Force...all com- manders. Moreover, normal Army campaign strategy and tac- tics for defending land areas inevitably left small areas or points open to attack...police services during special events. Large United Service Organizations ( USO ), Armed Forces Entertainment, and MWR functions are common

  11. From Statistical to Biological Interactions via Omics Integration

    OpenAIRE

    Bessonov, Kyrylo

    2016-01-01

    The XXI century opened a new ‘Big Data’ era in which, thanks to rapid technological advancements and appearance of high throughput technologies, vast amounts of unstructured omics data (e.g., transcriptomic, genomic, etc.) are generated every day. This thesis mainly focuses on solving the problems related diverse omics data integration and interaction identification tasks. Particular attention is given to useful knowledge extraction in the context of complex diseases including pathological me...

  12. The BIG Data Center: from deposition to integration to translation.

    Science.gov (United States)

    2017-01-04

    Biological data are generated at unprecedentedly exponential rates, posing considerable challenges in big data deposition, integration and translation. The BIG Data Center, established at Beijing Institute of Genomics (BIG), Chinese Academy of Sciences, provides a suite of database resources, including (i) Genome Sequence Archive, a data repository specialized for archiving raw sequence reads, (ii) Gene Expression Nebulas, a data portal of gene expression profiles based entirely on RNA-Seq data, (iii) Genome Variation Map, a comprehensive collection of genome variations for featured species, (iv) Genome Warehouse, a centralized resource housing genome-scale data with particular focus on economically important animals and plants, (v) Methylation Bank, an integrated database of whole-genome single-base resolution methylomes and (vi) Science Wikis, a central access point for biological wikis developed for community annotations. The BIG Data Center is dedicated to constructing and maintaining biological databases through big data integration and value-added curation, conducting basic research to translate big data into big knowledge and providing freely open access to a variety of data resources in support of worldwide research activities in both academia and industry. All of these resources are publicly available and can be found at http://bigd.big.ac.cn. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

  13. The BIG Data Center: from deposition to integration to translation

    Science.gov (United States)

    2017-01-01

    Biological data are generated at unprecedentedly exponential rates, posing considerable challenges in big data deposition, integration and translation. The BIG Data Center, established at Beijing Institute of Genomics (BIG), Chinese Academy of Sciences, provides a suite of database resources, including (i) Genome Sequence Archive, a data repository specialized for archiving raw sequence reads, (ii) Gene Expression Nebulas, a data portal of gene expression profiles based entirely on RNA-Seq data, (iii) Genome Variation Map, a comprehensive collection of genome variations for featured species, (iv) Genome Warehouse, a centralized resource housing genome-scale data with particular focus on economically important animals and plants, (v) Methylation Bank, an integrated database of whole-genome single-base resolution methylomes and (vi) Science Wikis, a central access point for biological wikis developed for community annotations. The BIG Data Center is dedicated to constructing and maintaining biological databases through big data integration and value-added curation, conducting basic research to translate big data into big knowledge and providing freely open access to a variety of data resources in support of worldwide research activities in both academia and industry. All of these resources are publicly available and can be found at http://bigd.big.ac.cn. PMID:27899658

  14. Integratives versus traditionelles Lernen aus Sicht der Studierenden [Integrative vs. Traditional Learning from the Student Perspective

    Directory of Open Access Journals (Sweden)

    Kadmon, Guni

    2011-05-01

    Full Text Available [english] Background: The interdisciplinary surgery block of the reformed undergraduate curriculum HeiCuMed includes daily cycles of interactive case-based seminars, problem-based tutorials, case presentation by students, skills and communication training, and bedside teaching. The teaching doctors receive didactic training. In contrast, the previous traditional course was based on lectures with only two weekly hours of bedside teaching. Didactic training was not available.Objective: The present work aims at analysing the importance of active participation of students and the didactic components of the reformed and traditional curricula, which contribute to successful learning as evaluated by the students.Method: Differentiated student evaluations of the undergraduate surgical courses between 1999 and 2008 were examined by correlation and regression analyses. Results: The evaluation scores for organisation, dedication of the teaching staff, their ability to make lessons interesting and complex topics easily understandable, and the subjective gain of knowledge were significantly better in HeiCuMed than in the traditional curriculum. However, the dependence of knowledge gain on the didactic quality was the same in both curricula. The quality of discussions and the ability of the teaching doctors to promote active student participation were important to the subjective gain of knowledge in both seminars and practical courses of the reformed curriculum as well as for the overall evaluation of the practical courses but not the gain of knowledge in the traditional curriculum. Conclusion: The findings confirm psychological-educational perceptions, that competent implementation of integrative didactical methods is more important to successful teaching and the subjective gain of knowledge than knowledge transfer by traditional classroom teaching. [german] Hintergrund: Der interdisziplinäre Chirurgische Block des Heidelberger Reformcurriculums Hei

  15. Electrochemical micro/nano-machining: principles and practices.

    Science.gov (United States)

    Zhan, Dongping; Han, Lianhuan; Zhang, Jie; He, Quanfeng; Tian, Zhao-Wu; Tian, Zhong-Qun

    2017-03-06

    Micro/nano-machining (MNM) is becoming the cutting-edge of high-tech manufacturing because of the increasing industrial demand for supersmooth surfaces and functional three-dimensional micro/nano-structures (3D-MNS) in ultra-large scale integrated circuits, microelectromechanical systems, miniaturized total analysis systems, precision optics, and so on. Taking advantage of no tool wear, no surface stress, environmental friendliness, simple operation, and low cost, electrochemical micro/nano-machining (EC-MNM) has an irreplaceable role in MNM. This comprehensive review presents the state-of-art of EC-MNM techniques for direct writing, surface planarization and polishing, and 3D-MNS fabrications. The key point of EC-MNM is to confine electrochemical reactions at the micro/nano-meter scale. This review will bring together various solutions to "confined reaction" ranging from electrochemical principles through technical characteristics to relevant applications.

  16. Classical and quantum dynamics from classical paths to path integrals

    CERN Document Server

    Dittrich, Walter

    2016-01-01

    Graduate students who want to become familiar with advanced computational strategies in classical and quantum dynamics will find here both the fundamentals of a standard course and a detailed treatment of the time-dependent oscillator, Chern-Simons mechanics, the Maslov anomaly and the Berry phase, to name a few. Well-chosen and detailed examples illustrate the perturbation theory, canonical transformations, the action principle and demonstrate the usage of path integrals. This new edition has been revised and enlarged with chapters on quantum electrodynamics, high energy physics, Green’s functions and strong interaction.

  17. From behavior to neural dynamics: An integrated theory of attention

    Science.gov (United States)

    Buschman, Timothy J.; Kastner, Sabine

    2015-01-01

    The brain has a limited capacity and therefore needs mechanisms to selectively enhance the information most relevant to one’s current behavior. We refer to these mechanisms as ‘attention’. Attention acts by increasing the strength of selected neural representations and preferentially routing them through the brain’s large-scale network. This is a critical component of cognition and therefore has been a central topic in cognitive neuroscience. Here we review a diverse literature that has studied attention at the level of behavior, networks, circuits and neurons. We then integrate these disparate results into a unified theory of attention. PMID:26447577

  18. Integrated systems: from library to campus and beyond.

    Science.gov (United States)

    Jones, C L; Marcum, D B

    1983-07-01

    Integrated library systems have not yet been created, although they have been emphasized for nearly two decades. Now and in the future, the task is even more complex because the principal issue is access to information itself, wherever it is located and in whatever form it may exist. The goal becomes more feasible because of changes in library practices achieved with technological innovation. Although individual elements of a campus-wide information system may already exist, the details for implementation are yet to be articulated.

  19. Integrable Cosmological Models From Higher Dimensional Einstein Equations

    CERN Document Server

    Sano, M; Sano, Masakazu; Suzuki, Hisao

    2007-01-01

    We consider the cosmological models for the higher dimensional spacetime which includes the curvatures of our space as well as the curvatures of the internal space. We find that the condition for the integrability of the cosmological equations is that the total space-time dimensions are D=10 or D=11 which is exactly the conditions for superstrings or M-theory. We obtain analytic solutions with generic initial conditions in the four dimensional Einstein frame and study the accelerating universe when both our space and the internal space have negative curvatures.

  20. Integrated presentation of ecological risk from multiple stressors.

    Science.gov (United States)

    Goussen, Benoit; Price, Oliver R; Rendal, Cecilie; Ashauer, Roman

    2016-10-26

    Current environmental risk assessments (ERA) do not account explicitly for ecological factors (e.g. species composition, temperature or food availability) and multiple stressors. Assessing mixtures of chemical and ecological stressors is needed as well as accounting for variability in environmental conditions and uncertainty of data and models. Here we propose a novel probabilistic ERA framework to overcome these limitations, which focusses on visualising assessment outcomes by construct-ing and interpreting prevalence plots as a quantitative prediction of risk. Key components include environmental scenarios that integrate exposure and ecology, and ecological modelling of relevant endpoints to assess the effect of a combination of stressors. Our illustrative results demonstrate the importance of regional differences in environmental conditions and the confounding interactions of stressors. Using this framework and prevalence plots provides a risk-based approach that combines risk assessment and risk management in a meaningful way and presents a truly mechanistic alternative to the threshold approach. Even whilst research continues to improve the underlying models and data, regulators and decision makers can already use the framework and prevalence plots. The integration of multiple stressors, environmental conditions and variability makes ERA more relevant and realistic.

  1. Action and language integration: from humans to cognitive robots.

    Science.gov (United States)

    Borghi, Anna M; Cangelosi, Angelo

    2014-07-01

    The topic is characterized by a highly interdisciplinary approach to the issue of action and language integration. Such an approach, combining computational models and cognitive robotics experiments with neuroscience, psychology, philosophy, and linguistic approaches, can be a powerful means that can help researchers disentangle ambiguous issues, provide better and clearer definitions, and formulate clearer predictions on the links between action and language. In the introduction we briefly describe the papers and discuss the challenges they pose to future research. We identify four important phenomena the papers address and discuss in light of empirical and computational evidence: (a) the role played not only by sensorimotor and emotional information but also of natural language in conceptual representation; (b) the contextual dependency and high flexibility of the interaction between action, concepts, and language; (c) the involvement of the mirror neuron system in action and language processing; (d) the way in which the integration between action and language can be addressed by developmental robotics and Human-Robot Interaction.

  2. Nutritional phenotype databases and integrated nutrition: from molecules to populations.

    Science.gov (United States)

    Gibney, Michael J; McNulty, Breige A; Ryan, Miriam F; Walsh, Marianne C

    2014-05-01

    In recent years, there has been a great expansion in the nature of new technologies for the study of all biologic subjects at the molecular and genomic level and these have been applied to the field of human nutrition. The latter has traditionally relied on a mix of epidemiologic studies to generate hypotheses, dietary intervention studies to test these hypotheses, and a variety of experimental approaches to understand the underlying explanatory mechanisms. Both the novel and traditional approaches have begun to carve out separate identities vís-a-vís their own journals, their own international societies, and their own national and international symposia. The present review draws on the advent of large national nutritional phenotype databases and related technological developments to argue the case that there needs to be far more integration of molecular and public health nutrition. This is required to address new joint approaches to such areas as the measurement of food intake, biomarker discovery, and the genetic determinants of nutrient-sensitive genotypes and other areas such as personalized nutrition and the use of new technologies with mass application, such as in dried blood spots to replace venipuncture or portable electronic devices to monitor food intake and phenotype. Future development requires the full integration of these 2 disciplines, which will provide a challenge to both funding agencies and to university training of nutritionists.

  3. Integrated presentation of ecological risk from multiple stressors

    Science.gov (United States)

    Goussen, Benoit; Price, Oliver R.; Rendal, Cecilie; Ashauer, Roman

    2016-10-01

    Current environmental risk assessments (ERA) do not account explicitly for ecological factors (e.g. species composition, temperature or food availability) and multiple stressors. Assessing mixtures of chemical and ecological stressors is needed as well as accounting for variability in environmental conditions and uncertainty of data and models. Here we propose a novel probabilistic ERA framework to overcome these limitations, which focusses on visualising assessment outcomes by construct-ing and interpreting prevalence plots as a quantitative prediction of risk. Key components include environmental scenarios that integrate exposure and ecology, and ecological modelling of relevant endpoints to assess the effect of a combination of stressors. Our illustrative results demonstrate the importance of regional differences in environmental conditions and the confounding interactions of stressors. Using this framework and prevalence plots provides a risk-based approach that combines risk assessment and risk management in a meaningful way and presents a truly mechanistic alternative to the threshold approach. Even whilst research continues to improve the underlying models and data, regulators and decision makers can already use the framework and prevalence plots. The integration of multiple stressors, environmental conditions and variability makes ERA more relevant and realistic.

  4. INTEGRATIVE APPROACH ON FRAMING THEORY FROM ITS MULTIPARADIGMATIC CONDITION

    Directory of Open Access Journals (Sweden)

    Juan Antonio Marín Albaladejo

    2014-06-01

    Full Text Available Framing theory has reached an increasing role in media communication research, including common principles between different research perspectives. Besides the multiple ways of understanding the concept of frame, a controversy about the types of frames exists. Despite considerable integrating research efforts (D’Angelo, 2002; De Vreese, 2005; Entman, 1993, 2004; López-Rabadán, 2010; Matthes, 2012; Reese, 2007; Scheufele, 1999, scholars have not reached yet full conceptual and methodological convergence, so that definitions, theoretical models, frames measuring mode, types of frames, processes or effects differ in each study (Scheufele, 1999. This article provides an updated review of the different paradigms that define research efforts on this theory, and mentions the advantages to invest in an integrative model or paradigmatic synthesis for future studies. Through a comprehensive review of the published literature, we propose two objectives. On the one hand, to provide a taxonomy of the types of frame to clarify differences detected among studies labeled under this theory. It also seeks to justify the need to consider Framing theory as a multiparadigmatic research program (D'Angelo, 2002 that could include all perspectives established so far.

  5. Cerebral mechanisms of prosodic integration: evidence from connected speech.

    Science.gov (United States)

    Hesling, Isabelle; Clément, Sylvain; Bordessoules, Martine; Allard, Michèle

    2005-02-15

    Using functional Magnetic Resonance Imaging (fMRI) and long connected speech stimuli, we addressed the question of neuronal networks involved in prosodic integration by comparing (1) differences in brain activity when hearing connected speech stimuli with high and low degrees of prosodic expression; (2) differences in brain activity in two different diotic listening conditions (normal speech delivery to both ears, i.e., NN; and low-pass-filtered speech delivery to both ears, i.e., FF); and (3) effects of high and low degrees of prosodic information in the NN and FF conditions. Twelve right-handed French men listened passively to the stimuli. Each stimulus induced a specific cerebral network, the flat one weakening activations, which were mainly reduced to the bilateral STG for both listening conditions. High degrees of prosodic information were found to trigger right specific activations in a wider neuronal network involved in speech integration (such as BA44, BA21-22 and BA39-40) than low degrees of prosodic information did. More precisely, the right BA44 was found to be specifically involved in the process of F(0) modulations, which are the main acoustic correlate of prosody. Not only do the results achieved in the present experiment using 30-s-long connected speech stimuli show the involvement of a bilateral neuronal network but they also strongly suggest that high degrees of prosodic information elicit activations in a wider neuronal network involved in speech perception than low degrees of prosodic information do.

  6. Resources from waste : integrated resource management phase 1 study report

    Energy Technology Data Exchange (ETDEWEB)

    Corps, C. [Asset Strategics, Victoria BC (Canada); Salter, S. [Farallon Consultants Ltd., Victoria, BC (Canada); Lucey, P. [Aqua-Tex Scientific Consulting Ltd., Victoria, BC (Canada); O' Riordan, J.

    2008-02-29

    Integrated resource management (IRM) of municipal waste streams and water systems requires a structured analysis of options that consider environmental aspects such as greenhouse gases, carbon taxes and credits. Each option's inputs and outputs are assessed to determine the net highest and best use and value. IRM focuses on resource recovery and extracting maximum value. It considers the overall net impact on the taxpayer and requires the integration of liquid and solid waste streams to maximize values for recovering energy in the form of biofuels, heat, minerals, water and reducing electricity demand. IRM is linked to water management through reuse of treated water for groundwater recharge and to offset potable water use for non-potable purposes such as irrigation, including potential commercial use, which contributes to maintaining or improving the health of watersheds. This report presented a conceptual design for the application of IRM in the province of British Columbia (BC) and analyzed its potential contribution to the provincial climate change agenda. The report discussed traditional waste management, the IRM approach, and resource recovery technology and opportunities. The business case for IRM in BC was also outlined. It was concluded that IRM has the potential to be a viable solution to water, solid and liquid waste management that should be less expensive, result in fewer environmental impacts, and provide greater flexibility than traditional approaches to waste management. 63 refs., 17 tabs., 21 figs., 10 appendices.

  7. 16 CFR 312.8 - Confidentiality, security, and integrity of personal information collected from children.

    Science.gov (United States)

    2010-01-01

    ... personal information collected from children. 312.8 Section 312.8 Commercial Practices FEDERAL TRADE... Confidentiality, security, and integrity of personal information collected from children. The operator must... personal information collected from children....

  8. Integrated SFM Techniques Using Data Set from Google Earth 3d Model and from Street Level

    Science.gov (United States)

    Inzerillo, L.

    2017-08-01

    Structure from motion (SfM) represents a widespread photogrammetric method that uses the photogrammetric rules to carry out a 3D model from a photo data set collection. Some complex ancient buildings, such as Cathedrals, or Theatres, or Castles, etc. need to implement the data set (realized from street level) with the UAV one in order to have the 3D roof reconstruction. Nevertheless, the use of UAV is strong limited from the government rules. In these last years, Google Earth (GE) has been enriched with the 3D models of the earth sites. For this reason, it seemed convenient to start to test the potentiality offered by GE in order to extract from it a data set that replace the UAV function, to close the aerial building data set, using screen images of high resolution 3D models. Users can take unlimited "aerial photos" of a scene while flying around in GE at any viewing angle and altitude. The challenge is to verify the metric reliability of the SfM model carried out with an integrated data set (the one from street level and the one from GE) aimed at replace the UAV use in urban contest. This model is called integrated GE SfM model (i-GESfM). In this paper will be present a case study: the Cathedral of Palermo.

  9. Trigonometric potentials arising from the spheroidal equation: Supersymmetric partners and integral formulas

    Science.gov (United States)

    Schulze-Halberg, Axel

    2016-06-01

    We construct supersymmetric partners of a quantum system featuring a class of trigonometric potentials that emerge from the spheroidal equation. Examples of both standard and confluent supersymmetric transformations are presented. Furthermore, we use integral formulas arising from the confluent supersymmetric formalism to derive new representations for single and multiple integrals of spheroidal functions.

  10. Thermal momentum distribution from path integrals with shifted boundary conditions

    CERN Document Server

    Giusti, Leonardo

    2011-01-01

    For a thermal field theory formulated in the grand canonical ensemble, the distribution of the total momentum is an observable characterizing the thermal state. We show that its cumulants are related to thermodynamic potentials. In a relativistic system for instance, the thermal variance of the total momentum is a direct measure of the enthalpy. We relate the generating function of the cumulants to the ratio of (a) a partition function expressed as a Matsubara path integral with shifted boundary conditions in the compact direction, and (b) the ordinary partition function. In this form the generating function is well suited for Monte-Carlo evaluation, and the cumulants can be extracted straightforwardly. We test the method in the SU(3) Yang-Mills theory and obtain the entropy density at three different temperatures.

  11. The Impact on Wind Power Integration from Geothermal Absorption

    DEFF Research Database (Denmark)

    Østergaard, Poul Alberg

    2012-01-01

    and lowtemperature geothermal resources. The analyses have also demonstrated that the municipality will still rely heavily on surrounding areas for electric load balancing assistance. With a departure in a previously elaborated 100% renewable energy scenario, this paper investigates how absorption heat pumps (AHP......Aalborg Municipality, Denmark is investigating ways of switching to 100 % renewable energy supply over the next 40 years. Analyses so far have demonstrated a potential for such a transition through energy savings, district heating (DH) and the use of locally available biomass, wind power......) and compression heat pumps (HP) for the supply of DH impact the integration of wind power. Hourly scenarioanalyses made using the EnergyPLAN model reveal a boiler production and electricity excess which is higher with AHPs than with HPs whereas condensing mode power generation is increased by the application...

  12. The Impact on Wind Power Integration from Geothermal Absorption

    DEFF Research Database (Denmark)

    Østergaard, Poul Alberg

    2012-01-01

    and lowtemperature geothermal resources. The analyses have also demonstrated that the municipality will still rely heavily on surrounding areas for electric load balancing assistance. With a departure in a previously elaborated 100% renewable energy scenario, this paper investigates how absorption heat pumps (AHP......Aalborg Municipality, Denmark is investigating ways of switching to 100 % renewable energy supply over the next 40 years. Analyses so far have demonstrated a potential for such a transition through energy savings, district heating (DH) and the use of locally available biomass, wind power......) and compression heat pumps (HP) for the supply of DH impact the integration of wind power. Hourly scenarioanalyses made using the EnergyPLAN model reveal a boiler production and electricity excess which is higher with AHPs than with HPs whereas condensing mode power generation is increased by the application...

  13. Integrating social science and genetics: news from the political front.

    Science.gov (United States)

    Hatemi, Peter K; Dawes, Christopher T; Frost-Keller, Amanda; Settle, Jaime E; Verhulst, Brad

    2011-01-01

    There has been growing interest in the use of genetic models to expand the understanding of political preferences, attitudes, and behaviors. Researchers in the social sciences have begun incorporating these models and have revealed that genetic differences account for individual differences in political beliefs, behaviors, and responses to the political environment. The first Integrating Genetics and the Social Sciences Conference, held at Boulder, Colorado in May of 2010, brought together these researchers. As a result, we jointly review the last 5 years of research in this area. In doing so, we explicate the methods, findings, and limitations of behavior genetic approaches, including twin designs, association studies, and genome-wide analyses, in their application toward exploring political preferences.

  14. Classical and quantum dynamics from classical paths to path integrals

    CERN Document Server

    Dittrich, Walter

    2017-01-01

    Graduate students who wish to become familiar with advanced computational strategies in classical and quantum dynamics will find in this book both the fundamentals of a standard course and a detailed treatment of the time-dependent oscillator, Chern-Simons mechanics, the Maslov anomaly and the Berry phase, to name just a few topics. Well-chosen and detailed examples illustrate perturbation theory, canonical transformations and the action principle, and demonstrate the usage of path integrals. The fifth edition has been revised and enlarged to include chapters on quantum electrodynamics, in particular, Schwinger’s proper time method and the treatment of classical and quantum mechanics with Lie brackets and pseudocanonical transformations. It is shown that operator quantum electrodynamics can be equivalently described with c-numbers, as demonstrated by calculating the propagation function for an electron in a prescribed classical electromagnetic field.

  15. Global sourcing - performance and integration : reflections on performance, implications from cross-functional and external integration

    NARCIS (Netherlands)

    Horn, Philipp

    2013-01-01

    Despite the fact that firms and individuals have been sourcing on a global basis since ancient times, global sourcing as a topic has received considerable attention from managers and scholars in recent years. Global business has been reported to be growing considerably during the last decades and

  16. Global sourcing - performance and integration : reflections on performance, implications from cross-functional and external integration

    NARCIS (Netherlands)

    Horn, Philipp

    2013-01-01

    Despite the fact that firms and individuals have been sourcing on a global basis since ancient times, global sourcing as a topic has received considerable attention from managers and scholars in recent years. Global business has been reported to be growing considerably during the last decades and th

  17. Integrated management of information inside maintenance processes. From the building registry to BIM systems

    Directory of Open Access Journals (Sweden)

    Cinzia Talamo

    2014-10-01

    Full Text Available The paper presents objec- tives, methods and results of two researches dealing with the improvement of integrated information management within maintenance processes. Focusing on information needs regarding the last phases of the building process, the two researches draft approaches characterizing a path of progressive improve- ment of strategies for integration: from a building registry, unique for the whole construction process, to an integrated management of the building process with the support of BIM systems.

  18. Developnemt of Integration Processes in Africa - from Political to Economic Goals

    OpenAIRE

    Marinov, Eduard

    2015-01-01

    The paper discusses the historic development and current trends in integration processes in Africa. Integration is seen as a means for ensuring competitiveness by better opportunities in international trade and as a factor supporting the resolution of the political and economic problems of the continent. Integration processes go through several stages of development, in which the focus gradually shifted from political to economic goals – the establishment of a functioning African Economic Com...

  19. Integrated circuit for processing a low-frequency signal from a seismic detector

    Energy Technology Data Exchange (ETDEWEB)

    Malashevich, N. I.; Roslyakov, A. S.; Polomoshnov, S. A., E-mail: S.Polomoshnov@tsen.ru; Fedorov, R. A. [Research and Production Complex ' Technological Center' of the Moscow Institute of Electronic Technology (Russian Federation)

    2011-12-15

    Specific features for the detection and processing of a low-frequency signal from a seismic detector are considered in terms of an integrated circuit based on a large matrix crystal of the 5507 series. This integrated circuit is designed for the detection of human movements. The specific features of the information signal, obtained at the output of the seismic detector, and the main characteristics of the integrated circuit and its structure are reported.

  20. Microgrippers: A case study for batch-compatible integration of MEMS with nanostructures

    DEFF Research Database (Denmark)

    Sardan, Özlem; Alaca, B. Erdem; Yalcinkaya, Arda Deniz;

    2007-01-01

    A batch- compatible integration of micro- electro- mechanical systems ( MEMS) with nanoscale objects is demonstrated using the example of a gripping device with nanoscale end- effectors. The proposed nanofabrication technique is based on creating a certain number of nanowires/ ribbons on a planar...... surface, each with a known orientation, using self- assembled crack networks as a template. Since both the location and orientation of the nanowires/ ribbons are known, the gripping device can be lithographically transferred on to the substrate ensuring full integration of MEMS with nanoscale end...

  1. Countermeasures for Intensive Use of Land from the Perspective of Urban-Rural Integration

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    This paper analyzes problems of excessive emphasis on expansion of urban land,improper village and town construction,and low land utilization efficiency in urban-rural integration construction.In line with characteristics and principle of intensive land use of urban-rural integration,it puts forward integration of urban-rural land layout,practically exploring connotation,and improving land intensification in many ways.Based on these,it presents countermeasures for intensive use of land from the perspective of urban-rural integration,including stressing function of overall planning of land use in integration and control of urban-rural regional development,raising population,ecological and economic bearing capacity of land on the condition of protecting arable land and focusing on intensive use of land,and promoting healthy,sustainable and coordinated development of industrialization,urbanization and urban-rural integration.

  2. Communication: Kirkwood-Buff integrals in the thermodynamic limit from small-sized molecular dynamics simulations

    Science.gov (United States)

    Cortes-Huerto, R.; Kremer, K.; Potestio, R.

    2016-10-01

    We present an accurate and efficient method to obtain Kirkwood-Buff (KB) integrals in the thermodynamic limit from small-sized molecular dynamics simulations. By introducing finite size effects into integral equations of statistical mechanics, we derive an analytical expression connecting the KB integrals of the bulk system with the fluctuations of the number of molecules in the corresponding closed system. We validate the method by calculating the activity coefficients of aqueous urea mixtures and the KB integrals of Lennard-Jones fluids. Moreover, our results demonstrate how to identify simulation conditions under which computer simulations reach the thermodynamic limit.

  3. From false integration of viewers on informative TV

    Directory of Open Access Journals (Sweden)

    Felisbela Lopes

    2011-12-01

    Full Text Available New media fast-paced technologies are constantly feeding the contemporary (telespectator with the promise of "empowerment". In the last decades, an "empowered user" notion is being built around the mythical narrative of 'omnipotence', that becomes the verb and the active complement to the modern promise of 'omnividence": the one who sees everything, can do everything. However, what we actually find when we scan the news and information broadcasts of portuguese TV, is that we don't find many traces of this supposedly "empowered" spectator. Broadcasts scarcely consider a structural participation of their public,or they only include spectators in euphemistical terms, letting them in just for the sake of having them in, thus treating the public not as citizens but as audiences and revealing a false "empowerment". In this article we analyze the integration of TV spectators on a total of 1673 news and information broadcasts in 6 Portuguese channels (RTP1, SIC, TVI, SICN, RTPN, TVI 24. This work is part of a research project called "Television journalism and citizenship".

  4. Minimizing dioxin emissions from integrated MSW thermal treatment.

    Science.gov (United States)

    Cheung, Wai Hung; Lee, Vinci K C; McKay, Gordon

    2007-03-15

    The combustion of wastes has very significant benefits in reducing the volume of waste materials and producing energy. However, combustion processes produce emissions, which must be below the Best Practical Means (BPM) specified legislative limits. Several wastes, such as tires and meat meal, have been successfully combusted in cement kilns, up to 20% w/w, while retaining emission standards well below legislative limits. In the case of municipal solid waste (MSW) the introduction of large amounts of MSW into cement kilns is not practical because the additional kiln volume required is too great, the large amounts of ash generated will affect the cement clinker quality, and it would be difficult to sustain the required very high clinkering temperature of 1500 degrees C with large quantities of low calorific value MSW. A completely novel process, termed the Co-Co process, has been developed, integrating MSW combustion in a synergistic fashion with the cement production. This process is based on combining the cement "front-end" calcination reaction and incorporating it with a high temperature, at 1200 degrees C, combustion process, providing a giant acid gas scrubber. A pilot plant was designed, constructed, and operated to demonstrate the benefits of the Co-Co process. The pilot plant achieved emissions minimization: dioxins were typically 0.5-1% of the European BPM limits, HCl, SOx, NOx, and particulates were 15, 10, 20, and 25% of BPM limits, respectively. Heavy metals were typically below 25% of BPM limit values.

  5. Cavalieri integration

    CSIR Research Space (South Africa)

    Ackermann, ER

    2012-09-01

    Full Text Available We use Cavalieri’s principle to develop a novel integration technique which we call Cavalieri integration. Cavalieri integrals differ from Riemann integrals in that non-rectangular integration strips are used. In this way we can use single Cavalieri...

  6. A Proposal for Considering Research Integrity from the Perspective of Behavioral Economics

    Directory of Open Access Journals (Sweden)

    Melissa S. Anderson

    2014-10-01

    Full Text Available This paper proposes that theory and findings from behavioral economics may shed light on research integrity and misconduct.  It suggests ways in which strategies based on behavioral theory and research might be used by principal investigators to support research integrity among their research teams.

  7. Entropy in Postmerger and Acquisition Integration from an Information Technology Perspective

    Science.gov (United States)

    Williams, Gloria S.

    2012-01-01

    Mergers and acquisitions have historically experienced failure rates from 50% to more than 80%. Successful integration of information technology (IT) systems can be the difference between postmerger success or failure. The purpose of this phenomenological study was to explore the entropy phenomenon during postmerger IT integration. To that end, a…

  8. TIME-DOMAIN VOLUME INTEGRAL EQUATION FOR TRANSIENT SCATTERING FROM INHOMOGENEOUS OBJECTS-2D TM CASE

    Institute of Scientific and Technical Information of China (English)

    Wang Jianguo; Fan Ruyu

    2001-01-01

    This letter proposes a time-domain volume integral equation based method for analyzing the transient scattering from a 2D inhomogeneous cylinder by involking the volume equivalence principle for the transverse magnetic case. This integral equation is solved by using an MOT scheme. Numerical results obtained using this method agree very well with those obtained using the FDTD method.

  9. TIME-DOMAIN VOLUME INTEGRAL EQUATION FOR TRANSIENT SCATTERING FROM INHOMOGENEOUS OBJECTS-2D TE CASE

    Institute of Scientific and Technical Information of China (English)

    Wang Jianguo; Fan Ruyu

    2001-01-01

    This letter proposes a time-domain volume integral equation based method for analyzing the transient scattering from a 2D inhomogeneous cylinder by involking the volume equivalence principle for the transverse electric case. This integral equation is solved by using an MOT scheme. Numerical results obtained using this method agree very well with those obtained using the FDTD method.

  10. Infrared High-Resolution Integrated Light Spectral Analyses of M31 Globular Clusters from APOGEE

    CERN Document Server

    Sakari, Charli M; Schiavon, Ricardo P; Bizyaev, Dmitry; Prieto, Carlos Allende; Beers, Timothy C; Caldwell, Nelson; Garcia-Hernandez, Domingo Anibal; Lucatello, Sara; Majewski, Steven; O'Connell, Robert W; Pan, Kaike; Strader, Jay

    2016-01-01

    Chemical abundances are presented for 25 M31 globular clusters (GCs), based on moderately high resolution (R = 22, 500) H-band integrated light spectra from the Apache Point Observatory Galactic Evolution Experiment (APOGEE). Infrared spectra offer lines from new elements, of different strengths, and at higher excitation potentials compared to the optical. Integrated abundances of C, N, and O are derived from CO, CN, and OH molecular features, while Fe, Na, Mg, Al, Si, K, Ca, and Ti abundances are derived from atomic features. These abundances are compared to previous results from the optical, demonstrating the validity and value of infrared integrated light analyses. The CNO abundances are consistent with typical tip of the red giant branch stellar abundances, but are systematically offset from optical, Lick index abundances. With a few exceptions, the other abundances agree between the optical and the infrared within the 1{\\sigma} uncertainties. The first integrated K abundances are also presented, and demo...

  11. Benchmark values for molecular two-electron integrals arising from the Dirac equation

    Science.gov (United States)

    Baǧcı, A.; Hoggan, P. E.

    2015-02-01

    The two-center two-electron Coulomb and hybrid integrals arising in relativistic and nonrelativistic ab initio calculations on molecules are evaluated. Compact, arbitrarily accurate expressions are obtained. They are expressed through molecular auxiliary functions and evaluated with the numerical Global-adaptive method for arbitrary values of parameters in the noninteger Slater-type orbitals. Highly accurate benchmark values are presented for these integrals. The convergence properties of new molecular auxiliary functions are investigated. The comparison for two-center two-electron integrals is made with results obtained from single center expansions by translation of the wave function to a single center with integer principal quantum numbers and results obtained from the Cuba numerical integration algorithm, respectively. The procedures discussed in this work are capable of yielding highly accurate two-center two-electron integrals for all ranges of orbital parameters.

  12. Benchmark values for molecular two-electron integrals arising from the Dirac equation.

    Science.gov (United States)

    Bağcı, A; Hoggan, P E

    2015-02-01

    The two-center two-electron Coulomb and hybrid integrals arising in relativistic and nonrelativistic ab initio calculations on molecules are evaluated. Compact, arbitrarily accurate expressions are obtained. They are expressed through molecular auxiliary functions and evaluated with the numerical Global-adaptive method for arbitrary values of parameters in the noninteger Slater-type orbitals. Highly accurate benchmark values are presented for these integrals. The convergence properties of new molecular auxiliary functions are investigated. The comparison for two-center two-electron integrals is made with results obtained from single center expansions by translation of the wave function to a single center with integer principal quantum numbers and results obtained from the Cuba numerical integration algorithm, respectively. The procedures discussed in this work are capable of yielding highly accurate two-center two-electron integrals for all ranges of orbital parameters.

  13. Findings from the Harvard Medical School Cambridge Integrated Clerkship, a Year-Long Longitudinal Psychiatry Experience.

    Science.gov (United States)

    Cheng, Elisa; Hirsh, David; Gaufberg, Elizabeth; Griswold, Todd; Wesley Boyd, J

    2017-06-23

    The Harvard Medical School Cambridge Integrated Clerkship is a longitudinal integrated clerkship that has provided an alternative clinical model for medical education in psychiatry since its inception in 2004. This study was undertaken in an effort to better understand the student experience of the Cambridge Integrated Clerkship and how it may have impacted students' perceptions of and interest in psychiatry, as well as performance. Qualitative surveys were sent via e-mail to the first 11 student cohorts who had completed the Cambridge Integrated Clerkship (from 2004 to 2014) and for whom we had e-mail addresses (N = 100), and the free-text responses were coded thematically. All available standardized scoring data and residency match data for Cambridge Integrated Clerkship graduates were obtained. From 2006 to 2014, 12 out of 73 Cambridge Integrated Clerkship students who entered the match chose a psychiatry residency (16.4%), four times more than students in traditional clerkships at Harvard Medical School (3.8% of 1355 students) or the national average (4.1% of 146,066 US applicants). Thirty of the 100 surveyed Cambridge Integrated Clerkship graduates (30%) responded to the qualitative survey with free-text remarks on a number of themes. Cambridge Integrated Clerkship students compared positively to their classmates in terms of standardized test performance. Their fourfold higher match rate into psychiatry compared to other students raises intriguing questions as to what role a longitudinal clerkship might have played in developing interest in psychiatry as a career.

  14. Critical exponents for a transition from integrability to non-integrability via localization of invariant tori in the Hamiltonian system

    Energy Technology Data Exchange (ETDEWEB)

    Leonel, Edson D; De Oliveira, Juliano A; Saif, Farhan, E-mail: edleonel@rc.unesp.br [Departamento de EstatIstica, Matematica Aplicada e Computacao, UNESP-Univ. Estadual Paulista, Av. 24A, 1515, Bela Vista, 13506-900 Rio Claro, Sao Paulo (Brazil)

    2011-07-29

    Critical exponents that describe a transition from integrability to non-integrability in a two-dimensional, nonlinear and area-preserving map are obtained via localization of the first invariant spanning curve (invariant tori) in the phase space. In a general class of systems, the position of the first invariant tori is estimated by reducing the mapping of the system to the standard mapping where a transition takes place from local to global chaos. The phase space of the mapping shows a large chaotic sea surrounding periodic islands and limited by a set of invariant tori whose position of the first of them depends on the control parameters. The formalism leads us to obtain analytically critical exponents that describe the behaviour of the average variable (action) along the chaotic sea. The result is compared to several models in the literature confirming the approach is of large interest. The formalism used is general and the procedure can be extended to many other different systems. (fast track communication)

  15. Networks: Blending and Integrating Data From Multiple Sources

    Energy Technology Data Exchange (ETDEWEB)

    Sheng, Shawn; Helsen, Jan

    2017-06-19

    This presentation covers gathering data from turbines to provide full transparency for reporting purposes, validating human-entered data to eradicate errors, exploring data-enabled remaining useful life predictions, and supervisory controls being used today.

  16. Three-dimensional nonparaxial accelerating beams from the transverse Whittaker integral

    Science.gov (United States)

    Zhang, Yiqi; Belić, Milivoj R.; Sun, Jia; Zheng, Huaibin; Chen, Haixia; Li, Changbiao; Wang, Zhiguo; Zhang, Yanpeng

    2014-08-01

    We investigate three-dimensional nonparaxial linear accelerating beams arising from the transverse Whittaker integral. These beams accelerate along a semicircular trajectory, with almost invariant nondiffracting shapes. The transverse patterns of accelerating beams are determined by their angular spectra, which are constructed from the Mathieu functions, Weber functions, and Fresnel integrals. Our results not only enrich the understanding of multidimensional nonparaxial accelerating beams, but also display their real applicative potential —owing to the usefulness of Mathieu and Weber functions, and Fresnel integrals in describing a wealth of wave phenomena in nature.

  17. Three-dimensional nonparaxial accelerating beams from the transverse Whittaker integral

    CERN Document Server

    Zhang, Yiqi; Zheng, Huaibin; Chen, Haixia; Li, Changbiao; Wang, Zhiguo; Zhang, Yanpeng

    2014-01-01

    We investigate three-dimensional nonparaxial linear accelerating beams arising from the transverse Whittaker integral. They include different Mathieu, Weber, and Fresnel beams, among other. These beams accelerate along a semicircular trajectory, with almost invariant nondiffracting shapes. The transverse patterns of accelerating beams are determined by their angular spectra, which are constructed from the Mathieu functions, Weber functions, and Fresnel integrals. Our results not only enrich the understanding of multidimensional nonparaxial accelerating beams, but also display their real applicative potential -- owing to the usefulness of Mathieu and Weber functions, and Fresnel integrals in describing a wealth of wave phenomena in nature.

  18. Efficient ethanol recovery from yeast fermentation broth with integrated distillation-membrane process

    Science.gov (United States)

    A hybrid process integrating vapor stripping with vapor compression and vapor permeation membrane separation, termed Membrane Assisted Vapor Stripping (MAVS), was evaluated for recovery and dehydration of ethanol from aqueous solution as an alternative to conventional distillatio...

  19. Efficient ethanol recovery from yeast fermentation broth with integrated distillation-membrane process

    Science.gov (United States)

    A hybrid process integrating vapor stripping with vapor compression and vapor permeation membrane separation, termed Membrane Assisted Vapor Stripping (MAVS), was evaluated for recovery and dehydration of ethanol from aqueous solution as an alternative to conventional distillatio...

  20. Suitability of integrated protection diodes from diverse semiconductor technologies

    NARCIS (Netherlands)

    Wanum, van Maurice; Lebouille, Tom; Visser, Guido; Vliet, van Frank E.

    2009-01-01

    Abstract In this article diodes from three different semiconductor technologies are compared based on their suitability to protect a receiver. The semiconductor materials involved are silicon, gallium arsenide and gallium nitride. The diodes in the diverse semiconductor technologies themselves are c

  1. Suitability of integrated protection diodes from diverse semiconductor technologies

    NARCIS (Netherlands)

    Wanum, M. van; Lebouille, T.T.N.; Visser, G.C.; Vliet, F.E. van

    2009-01-01

    In this article diodes from three different semiconductor technologies are compared based on their suitability to protect a receiver. The semiconductor materials involved are Silicon, Gallium Arsenide and Gallium Nitride. The diodes in the diverse semiconductor technologies themselves are close in p

  2. Integrating Learning from Examples into the Search for Diagnostic Policies

    CERN Document Server

    Bayer-Zubek, V; 10.1613/jair.1512

    2011-01-01

    This paper studies the problem of learning diagnostic policies from training examples. A diagnostic policy is a complete description of the decision-making actions of a diagnostician (i.e., tests followed by a diagnostic decision) for all possible combinations of test results. An optimal diagnostic policy is one that minimizes the expected total cost, which is the sum of measurement costs and misdiagnosis costs. In most diagnostic settings, there is a tradeoff between these two kinds of costs. This paper formalizes diagnostic decision making as a Markov Decision Process (MDP). The paper introduces a new family of systematic search algorithms based on the AO* algorithm to solve this MDP. To make AO* efficient, the paper describes an admissible heuristic that enables AO* to prune large parts of the search space. The paper also introduces several greedy algorithms including some improvements over previously-published methods. The paper then addresses the question of learning diagnostic policies from examples. Wh...

  3. Integrating Problem Solvers from Analogous Markets in New Product Ideation

    DEFF Research Database (Denmark)

    Franke, Nikolaus; Poetz, Marion; Schreier, Martin

    2014-01-01

    Who provides better inputs to new product ideation tasks, problem solvers with expertise in the area for which new products are to be developed or problem solvers from “analogous” markets that are distant but share an analogous problem or need? Conventional wisdom appears to suggest that target...... that including problem solvers from analogous markets versus the target market accounts for almost two-thirds of the well-known effect of involving lead users instead of average problem solvers. This effect is further amplified when the analogous distance between the markets increases, i.e., when searching...... market expertise is indispensable, which is why most managers searching for new ideas tend to stay within their own market context even when they do search outside their firms' boundaries. However, in a unique symmetric experiment that isolates the effect of market origin, we find evidence...

  4. Coordinate Systems Integration for Craniofacial Database from Multimodal Devices

    Directory of Open Access Journals (Sweden)

    Deni Suwardhi

    2005-05-01

    Full Text Available This study presents a data registration method for craniofacial spatial data of different modalities. The data consists of three dimensional (3D vector and raster data models. The data is stored in object relational database. The data capture devices are Laser scanner, CT (Computed Tomography scan and CR (Close Range Photogrammetry. The objective of the registration is to transform the data from various coordinate systems into a single 3-D Cartesian coordinate system. The standard error of the registration obtained from multimodal imaging devices using 3D affine transformation is in the ranged of 1-2 mm. This study is a step forward for storing the craniofacial spatial data in one reference system in database.

  5. Integrating data converters for picoampere currents from electrochemical transducers

    DEFF Research Database (Denmark)

    Breten, Madalina; Lehmann, Torsten; Bruun, Erik

    2000-01-01

    This paper describes a current mode A/D converter designed for a maximum input current range of 5 nA and a resolution of the order of 1 pA. The converter is designed for a potentiostat for amperometric chemical sensors and provides a constant polarization voltage for the measuring electrode....... A prototype chip using the dual slope conversion method has been fabricated in a 0.7 μm CMOS process. Experimental results from this converter are reported. Design problems and limitations of the converter are discussed and a new conversion technique providing a larger dynamic range and easy calibration...

  6. Integrating feedback from a clinical data warehouse into practice organisation.

    Science.gov (United States)

    Grant, Andrew; Moshyk, Andriy; Diab, Hassan; Caron, Philippe; de Lorenzi, Fabien; Bisson, Guy; Menard, Line; Lefebvre, Richard; Gauthier, Patricia; Grondin, Richard; Desautels, Michel

    2006-01-01

    A patient oriented hospital information system (ARIANE) was inaugurated at the Sherbrooke University hospital (CHUS) in 1990 and a clinical data warehouse (CDW) completed 2004. The CDW is updated from ARIANE every 24h and includes ICD discharge diagnosis data, visit DRG and SNOMED encoding. The data is encrypted on storage. Data is accessed according to institutional approval. To facilitate data access two levels of tool have been made accessible using a web-browser. The first level consists of a 'dashboard' that has a defined design and enables a set of pre-determined dynamic queries about a patient population. This level can be operated with minimal training. The second level uses a convivial database query tool, which requires some prior training. Two prototype dashboards have been designed and evaluated for acceptability. The first for the emergency department enables analysis of patient occupancy. The second for the biochemistry department enables quality assurance evaluation. In most cases worldwide the clinical data warehouse is only beginning to be exploited, often impeded by lack of connection between different enterprise databases. Our CDW is expected rapidly to create a culture change so that clinical practice can be continuously evaluated using compiled data readily available from the electronic health record/hospital information system.

  7. Super-resolution for imagery from integrated microgrid polarimeters.

    Science.gov (United States)

    Hardie, Russell C; LeMaster, Daniel A; Ratliff, Bradley M

    2011-07-04

    Imagery from microgrid polarimeters is obtained by using a mosaic of pixel-wise micropolarizers on a focal plane array (FPA). Each distinct polarization image is obtained by subsampling the full FPA image. Thus, the effective pixel pitch for each polarization channel is increased and the sampling frequency is decreased. As a result, aliasing artifacts from such undersampling can corrupt the true polarization content of the scene. Here we present the first multi-channel multi-frame super-resolution (SR) algorithms designed specifically for the problem of image restoration in microgrid polarization imagers. These SR algorithms can be used to address aliasing and other degradations, without sacrificing field of view or compromising optical resolution with an anti-aliasing filter. The new SR methods are designed to exploit correlation between the polarimetric channels. One of the new SR algorithms uses a form of regularized least squares and has an iterative solution. The other is based on the faster adaptive Wiener filter SR method. We demonstrate that the new multi-channel SR algorithms are capable of providing significant enhancement of polarimetric imagery and that they outperform their independent channel counterparts.

  8. The Conceptual Integration Modeling Framework: Abstracting from the Multidimensional Model

    CERN Document Server

    Rizzolo, Flavio; Pottinger, Rachel; Wong, Kwok

    2010-01-01

    Data warehouses are overwhelmingly built through a bottom-up process, which starts with the identification of sources, continues with the extraction and transformation of data from these sources, and then loads the data into a set of data marts according to desired multidimensional relational schemas. End user business intelligence tools are added on top of the materialized multidimensional schemas to drive decision making in an organization. Unfortunately, this bottom-up approach is costly both in terms of the skilled users needed and the sheer size of the warehouses. This paper proposes a top-down framework in which data warehousing is driven by a conceptual model. The framework offers both design time and run time environments. At design time, a business user first uses the conceptual modeling language as a multidimensional object model to specify what business information is needed; then she maps the conceptual model to a pre-existing logical multidimensional representation. At run time, a system will tra...

  9. From mechanisms to function: an integrated framework of animal innovation

    Science.gov (United States)

    Tebbich, Sabine; Griffin, Andrea S.; Peschl, Markus F.; Sterelny, Kim

    2016-01-01

    Animal innovations range from the discovery of novel food types to the invention of completely novel behaviours. Innovations can give access to new opportunities, and thus enable innovating agents to invade and create novel niches. This in turn can pave the way for morphological adaptation and adaptive radiation. The mechanisms that make innovations possible are probably as diverse as the innovations themselves. So too are their evolutionary consequences. Perhaps because of this diversity, we lack a unifying framework that links mechanism to function. We propose a framework for animal innovation that describes the interactions between mechanism, fitness benefit and evolutionary significance, and which suggests an expanded range of experimental approaches. In doing so, we split innovation into factors (components and phases) that can be manipulated systematically, and which can be investigated both experimentally and with correlational studies. We apply this framework to a selection of cases, showing how it helps us ask more precise questions and design more revealing experiments. PMID:26926285

  10. From r-spin intersection numbers to Hodge integrals

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Xiang-Mao; Li, Yuping [Institute of Applied Mathematics, Academy of Mathematics and Systems Science,Chinese Academy of Sciences,Beijing 100190, People’s Republic of (China); Meng, Lingxian [Institute of Applied Mathematics, Academy of Mathematics and Systems Science,Chinese Academy of Sciences,Beijing 100190, People’s Republic of (China); College of Mathematics and Information Science, Zhengzhou University of Light Industry,Zhengzhou 450002, People’s Republic of (China)

    2016-01-04

    Generalized Kontsevich Matrix Model (GKMM) with a certain given potential is the partition function of r-spin intersection numbers. We represent this GKMM in terms of fermions and expand it in terms of the Schur polynomials by boson-fermion correspondence, and link it with a Hurwitz partition function and a Hodge partition by operators in a (GL)-hat (∞) group. Then, from a W{sub 1+∞} constraint of the partition function of r-spin intersection numbers, we get a W{sub 1+∞} constraint for the Hodge partition function. The W{sub 1+∞} constraint completely determines the Schur polynomials expansion of the Hodge partition function.

  11. From mechanisms to function: an integrated framework of animal innovation.

    Science.gov (United States)

    Tebbich, Sabine; Griffin, Andrea S; Peschl, Markus F; Sterelny, Kim

    2016-03-19

    Animal innovations range from the discovery of novel food types to the invention of completely novel behaviours. Innovations can give access to new opportunities, and thus enable innovating agents to invade and create novel niches. This in turn can pave the way for morphological adaptation and adaptive radiation. The mechanisms that make innovations possible are probably as diverse as the innovations themselves. So too are their evolutionary consequences. Perhaps because of this diversity, we lack a unifying framework that links mechanism to function. We propose a framework for animal innovation that describes the interactions between mechanism, fitness benefit and evolutionary significance, and which suggests an expanded range of experimental approaches. In doing so, we split innovation into factors (components and phases) that can be manipulated systematically, and which can be investigated both experimentally and with correlational studies. We apply this framework to a selection of cases, showing how it helps us ask more precise questions and design more revealing experiments.

  12. Reconstruction of Planar Domains from Partial Integral Measurements

    CERN Document Server

    Batenkov, Dmitry; Yomdin, Yosef

    2012-01-01

    We consider the problem of reconstruction of planar domains from their moments. Specifically, we consider domains with boundary which can be represented by a union of a finite number of pieces whose graphs are solutions of a linear differential equation with polynomial coefficients. This includes domains with piecewise-algebraic and, in particular, piecewise-polynomial boundaries. Our approach is based on one-dimensional reconstruction method of [Bat]* and a kind of "separation of variables" which reduces the planar problem to two one-dimensional problems, one of them parametric. Several explicit examples of reconstruction are given. Another main topic of the paper concerns "invisible sets" for various types of incomplete moment measurements. We suggest a certain point of view which stresses remarkable similarity between several apparently unrelated problems. In particular, we discuss zero quadrature domains (invisible for harmonic polynomials), invisibility for powers of a given polynomial, and invisibility ...

  13. Spatial data integration from distributed and heterogeneous sources

    Directory of Open Access Journals (Sweden)

    Genoveva Vargas S.

    2004-01-01

    Full Text Available El presente trabajo discute los retos asociados a la integración de datos espaciales y presenta el enfoque adoptado en el proyecto SPIDHERS (SPatial data Integraction from Distributed and HEteRogeneous Sources – Integración de Datos Espaciales a partir de Fuentes Heterogéneas y Distribuidas basado en técnicas de mediación, recuperación, análisis y extracción eficientes de datos. Finalmente, este trabajo muestra la forma en que se puede utilizar la tecnología producida en SPIDHERS para integrar, analizar y tomar decisiones utilizando datos del Popocatépetl, volcán ubicado en la región de Puebla y la Ciudad de México.

  14. Advanced Energy Harvesting from Macroalgae—Innovative Integration of Drying, Gasification and Combined Cycle

    Directory of Open Access Journals (Sweden)

    Muhammad Aziz

    2014-12-01

    Full Text Available State-of-the-art integrated macroalgae utilization processes, consisting of drying, gasification, and combined cycle, are proposed and their performance with respect to energy efficiency are evaluated. To achieve high exergy efficiency, the integration is performed through two main principles: exergy recovery and process integration. Initially, the energy involved in one process is recirculated intensively through exergy elevation and effective heat coupling. Furthermore, the unrecoverable energy from one process will be utilized in the other processes through process integration. As the result, the total exergy destruction from the whole integrated processes can be minimized significantly leading to significant improvement in energy efficiency. The first analysis relates to the performance of integrated drying process, especially the influence of target moisture content to energy consumption. Furthermore, the influences of gasification fluidization velocity to the total generated power and power generation efficiency are also calculated. As the results of study, the proposed integrated-processes proved a very high energy efficiency. A positive energy harvesting with the total power generation efficiency of about 40% could be achieved.

  15. With a little help from our friends: couple social integration in marriage.

    Science.gov (United States)

    Barton, Allen W; Futris, Ted G; Nielsen, Robert B

    2014-12-01

    The benefits of social integration (i.e., structural or affective connectedness with others and with social institutions) have been frequently noted for individuals' personal well-being. In a similar fashion, recent marital research has highlighted how the social integration of a couple also appears to positively affect marital well-being. However, beyond main effects, little research to date has considered whether couples' social integration possesses moderating effects for spouses' marital quality as well. Among a sample of 492 married individuals, the present study explored whether spouses' reports of the social integration of their marriage moderated the associations between (a) financial distress and marital happiness, and (b) residing in more urban areas and marital happiness. Results from latent interaction structural equation modeling revealed a significant interaction between couple social integration and each contextual factor. Specifically, higher levels of couple social integration buffered marital happiness from lower levels associated with greater financial distress and with residing in more urban areas. These results, along with cultural shifts that have led to lower levels of communal ties and involvement throughout society, suggest couple social integration to be a pertinent construct for marital research and enrichment efforts.

  16. Integrated Arrays on Silicon at Terahertz Frequencies

    Science.gov (United States)

    Chattopadhayay, Goutam; Lee, Choonsup; Jung, Cecil; Lin, Robert; Peralta, Alessandro; Mehdi, Imran; Llombert, Nuria; Thomas, Bertrand

    2011-01-01

    In this paper we explore various receiver font-end and antenna architecture for use in integrated arrays at terahertz frequencies. Development of wafer-level integrated terahertz receiver front-end by using advanced semiconductor fabrication technologies and use of novel integrated antennas with silicon micromachining are reported. We report novel stacking of micromachined silicon wafers which allows for the 3-dimensional integration of various terahertz receiver components in extremely small packages which easily leads to the development of 2- dimensioanl multi-pixel receiver front-ends in the terahertz frequency range. We also report an integrated micro-lens antenna that goes with the silicon micro-machined front-end. The micro-lens antenna is fed by a waveguide that excites a silicon lens antenna through a leaky-wave or electromagnetic band gap (EBG) resonant cavity. We utilized advanced semiconductor nanofabrication techniques to design, fabricate, and demonstrate a super-compact, low-mass submillimeter-wave heterodyne frontend. When the micro-lens antenna is integrated with the receiver front-end we will be able to assemble integrated heterodyne array receivers for various applications such as multi-pixel high resolution spectrometer and imaging radar at terahertz frequencies.

  17. Antipsychotics from theory to practice: integrating clinical and basic data.

    Science.gov (United States)

    Tandon, R; Milner, K; Jibson, M D

    1999-01-01

    The recent introduction of the atypical antipsychotics into the treatment arena for psychoses and related disorders comes with justifiable excitement. These newer antipsychotics offer several clinical benefits over the conventional antipsychotics, which have been the mainstays of care thus far. The primary advantage of these atypical agents is their superior side effect profiles, particularly with regard to extrapyramidal side effects (EPS). The implications from a reduction in EPS touch on virtually every aspect of pathology in schizophrenic illness, including short- and long-term movement disorders, negative symptoms, noncompliance, cognitive dysfunction, and dysphoria. It should be emphasized that while atypical antipsychotics share many clinical attributes, there are also substantial differences among them. This review will examine the pharmacology, clinical efficacy, and side effect profiles of the atypical antipsychotics and attempt to relate the attributes observed in clinical practice and clinical trials to their basic pharmacologic profiles. There is a fair, but not perfect, correspondence between the pharmacologic profiles of the different atypical antipsychotics and their respective clinical attributes. After a comparative overview of their receptor-binding profiles, a brief pharmacokinetic summary will be provided. Finally, the clinical profiles of these agents will be summarized with regard to both their efficacy and adverse effects.

  18. Insights to integrated river management from a geomorphological viewpoint

    Science.gov (United States)

    Valyrakis, Manousos; Liu, Da

    2016-04-01

    In the context of increasing magnitude and frequency of extreme hydrologic events, eco-hydraulic engineers have a dual role of providing novel designs that both help stabilise river systems, as well as help effectively route floodwater safely downstream, though the catchment. One of such soft and green measures commonly used in engineering to protect channel banks and floodplains, is riverbank vegetation. Riverbank vegetation can be of high importance both in preserving the form (morphology) and function (ecology) of our natural as well as engineered river systems. Here the results of an experimental flume study, investigating riverbank hydrodynamics are presented. The effect of different riverbank vegetation densities on flow hydrodynamics across the channel are reported and discussed. Flow diagnostics including mean and turbulent intensity flow profiles along the streamwise and lateral directions, are being assessed via acoustic Doppler velocimetry (ADV) both at the main channel and within the riverbank. The configuration of vegetation elements follows a linear or staggered arrangement as vegetation density is progressively increased. Implications for sediment transport are discussed by considering the change in near-bed shear stresses at the main channel (increasing) and riverbank (decreasing) as the riverbank density increases. As such processes have the potential to affect both the form and function of the river system, the insights from this study are of significant importance to geomorphologists and hydraulic engineers, as well as ecologists.

  19. Integrating messages from the eating disorders field into obesity prevention.

    Science.gov (United States)

    Neumark-Sztainer, Dianne

    2012-12-01

    Weight-related problems, including unhealthy weight control behaviors, binge eating, overweight and obesity, and eating disorders, are prevalent in youth. Furthermore, many young people exhibit more than one of these problems. Therefore, it is essential to consider how to simultaneously work toward the prevention of a broad range of weight-related problems in youth. Dieting, body dissatisfaction, weight talk, and weight-related teasing are commonly addressed risk factors within eating disorder prevention interventions, whereas low levels of physical activity and high intakes of foods high in fat and sugar are commonly addressed within interventions aimed at obesity prevention. Empirical data to be presented in this article demonstrate why risk factors such as dieting and body dissatisfaction, which are typically addressed within the eating disorder field, need to also be addressed within the obesity field. Although dieting and body dissatisfaction strongly predict weight gain over time, these findings are not always taken into account in the design of obesity interventions for youth. Possible reasons as to why risk factors such as dieting, body dissatisfaction, and weight stigmatization may be not adequately addressed within interventions addressing obesity are discussed. Suggestions for how physicians and other nonphysician clinicians might link messages from the fields of both eating disorders and obesity into their work with youth are provided. Finally, the potential for work on mindfulness and yoga to decrease risk factors for both eating disorders and obesity are explored.

  20. Display of travelling 3D scenes from single integral-imaging capture

    Science.gov (United States)

    Martinez-Corral, Manuel; Dorado, Adrian; Hong, Seok-Min; Sola-Pikabea, Jorge; Saavedra, Genaro

    2016-06-01

    Integral imaging (InI) is a 3D auto-stereoscopic technique that captures and displays 3D images. We present a method for easily projecting the information recorded with this technique by transforming the integral image into a plenoptic image, as well as choosing, at will, the field of view (FOV) and the focused plane of the displayed plenoptic image. Furthermore, with this method we can generate a sequence of images that simulates a camera travelling through the scene from a single integral image. The application of this method permits to improve the quality of 3D display images and videos.

  1. Automatic Authorship Detection Using Textual Patterns Extracted from Integrated Syntactic Graphs

    Science.gov (United States)

    Gómez-Adorno, Helena; Sidorov, Grigori; Pinto, David; Vilariño, Darnes; Gelbukh, Alexander

    2016-01-01

    We apply the integrated syntactic graph feature extraction methodology to the task of automatic authorship detection. This graph-based representation allows integrating different levels of language description into a single structure. We extract textual patterns based on features obtained from shortest path walks over integrated syntactic graphs and apply them to determine the authors of documents. On average, our method outperforms the state of the art approaches and gives consistently high results across different corpora, unlike existing methods. Our results show that our textual patterns are useful for the task of authorship attribution. PMID:27589740

  2. From frequency of use to social integration: The mediation of routinization and infusion in Tuenti community

    Directory of Open Access Journals (Sweden)

    José L. Roldán

    2017-05-01

    Full Text Available This study examines post-adoption behaviors (i.e., frequency of use, routinization and infusion and their effects on the sense of community in the domain of social network sites. In particular, this contribution formulates mediation hypotheses, which posit how frequency of use affects social integration via routinization and infusion. The data was collected from 278 users of Tuenti, a highly-popular social network site among the Spanish college student population during the period 2006–2012. Results from partial least squares structural equation modeling (PLS-SEM show these sophisticated types of usage are interrelated in such a way that routinization and infusion (a fully mediate the effect of frequency of use on social integration; and (b exert significant influences on social integration, as an active sense of belongingness to a social network site. In order to attain social integration, it is therefore essential for managers to devise strategies to foster advanced post-adoption behaviors.

  3. On the moments and distribution of discrete Choquet integrals from continuous distributions

    Science.gov (United States)

    Kojadinovic, Ivan; Marichal, Jean-Luc

    2009-08-01

    We study the moments and the distribution of the discrete Choquet integral when regarded as a real function of a random sample drawn from a continuous distribution. Since the discrete Choquet integral includes weighted arithmetic means, ordered weighted averaging functions, and lattice polynomial functions as particular cases, our results encompass the corresponding results for these aggregation functions. After detailing the results obtained in [J.-L. Marichal, I. Kojadinovic, Distribution functions of linear combinations of lattice polynomials from the uniform distribution, Statistics & Probability Letters 78 (2008) 985-991] in the uniform case, we present results for the standard exponential case, show how approximations of the moments can be obtained for other continuous distributions such as the standard normal, and elaborate on the asymptotic distribution of the Choquet integral. The results presented in this work can be used to improve the interpretation of discrete Choquet integrals when employed as aggregation functions.

  4. Integral type operators from normal weighted Bloch spaces to QT,S spaces

    Directory of Open Access Journals (Sweden)

    Yongyi GU

    2016-08-01

    Full Text Available Operator theory is an important research content of the analytic function space theory. The discussion of simultaneous operator and function space is an effective way to study operator and function space. Assuming that  is an analytic self map on the unit disk Δ, and the normal weighted bloch space μ-B is a Banach space on the unit disk Δ, defining a composition operator C∶C(f=f on μ-B for all f∈μ-B, integral type operator JhC and CJh are generalized by integral operator and composition operator. The boundeness and compactness of the integral type operator JhC acting from normal weighted Bloch spaces to QT,S spaces are discussed, as well as the boundeness of the integral type operators CJh acting from normal weighted Bloch spaces to QT,S spaces. The related sufficient and necessary conditions are given.

  5. Postnatal experiences influence how the brain integrates information from different senses

    Directory of Open Access Journals (Sweden)

    Barry E Stein

    2009-09-01

    Full Text Available Sensory Processing Disorder (SPD is characterized by anomalous reactions to, and integration of, sensory cues. Although the underlying etiology of SPD is unknown, one brain region likely to reflect these sensory and behavioral anomalies is the Superior Colliculus (SC; a structure involved in the synthesis of information from multiple sensory modalities and the control of overt orientation responses. In this review we describe normal functional properties of this structure, the manner in which its individual neurons integrate cues from different senses, and the overt SC-mediated behaviors that are believed to manifest this “multisensory integration.” Of particular interest here is how SC neurons develop their capacity to engage in multisensory integration during early postnatal life as a consequence of early sensory experience, and that it is the intimate communication between cortex and the midbrain makes this developmental process possible.

  6. Distribution of Flagella Secreted Protein and Integral Membrane Protein Among Campylobacter jejuni Isolated from Thailand

    Science.gov (United States)

    2011-01-01

    secreted protein and integral membrane protein among Campylobacter jejuni isolated from Thailand Piyarat Pootong 1·, Oralak Serichantalergs...Ladaporn Bodhidatta \\ Frederic Poly2, Patricia Guerry2 and Carl J Mason 1 Abstract Background: Campylobacter jejuni, a gram-negative bacterium, is a...groups of integral membrane protein. The significance of these different FspA variants to virulence requires further study. Background Campylobacter

  7. INDIGO - INtegrated data warehouse of microbial genomes with examples from the red sea extremophiles.

    KAUST Repository

    Alam, Intikhab

    2013-12-06

    The next generation sequencing technologies substantially increased the throughput of microbial genome sequencing. To functionally annotate newly sequenced microbial genomes, a variety of experimental and computational methods are used. Integration of information from different sources is a powerful approach to enhance such annotation. Functional analysis of microbial genomes, necessary for downstream experiments, crucially depends on this annotation but it is hampered by the current lack of suitable information integration and exploration systems for microbial genomes.

  8. Ranking of integration factors within supply chains of forward and backward types - recommendations from researches

    Directory of Open Access Journals (Sweden)

    Bernd Hentschel

    2015-06-01

    management, production planning and accessibility of recycled materials.  Conclusions: The integration offers new possibilities therefore it is the promising option of actions. In complicated and complex logistic reality, it is more and more difficult to function, in economic sense, without starting and tightening close cooperation. Sometimes it is even not possible at all.  The growing popularity of two-way supply chains opens the dimensions of the possible cooperation. However, both science and the practice need the reliable quantitative information covering the conscious creation of the integration in supply chains. Such tool could be a ranking, recommended in this paper, of integration factors from the perspective of three measures of evaluation of global level of functioning of the supply chain.

  9. A Bayesian Approach to Discovering Truth from Conflicting Sources for Data Integration

    CERN Document Server

    Zhao, Bo; Gemmell, Jim; Han, Jiawei

    2012-01-01

    In practical data integration systems, it is common for the data sources being integrated to provide conflicting information about the same entity. Consequently, a major challenge for data integration is to derive the most complete and accurate integrated records from diverse and sometimes conflicting sources. We term this challenge the truth finding problem. We observe that some sources are generally more reliable than others, and therefore a good model of source quality is the key to solving the truth finding problem. In this work, we propose a probabilistic graphical model that can automatically infer true records and source quality without any supervision. In contrast to previous methods, our principled approach leverages a generative process of two types of errors (false positive and false negative) by modeling two different aspects of source quality. In so doing, ours is also the first approach designed to merge multi-valued attribute types. Our method is scalable, due to an efficient sampling-based inf...

  10. From Great Men to Ordinary Citizens? The Biographical Approach to Narrating European Integration in Museums

    Directory of Open Access Journals (Sweden)

    Wolfram Kaiserm

    2011-10-01

    Full Text Available The history of European integration is not easy to tell – in books or, for that matter, in museums. Most importantly, it appears to lack drama. This lack of drama creates a dilemma for museum practitioners who wish to tell stories about the contemporary history of Europe as shared history. In these circumstances, one prominent way of telling stories about European integration history in museums, and the focus of this article, is the biographical approach. Drawing upon research in all of the museums mentioned in this article and many more, and some 60 interviews with museum practitioners from across Europe, this article first discusses three biographical approaches to narrating European integration history in museums. It proceeds to draw out general conclusions about the prospects of mainstreaming European integration in history museums, and about the particular opportunities and pitfalls of the biographical approach and its different varieties.

  11. Developmental integration in a functional unit: deciphering processes from adult dental morphology.

    Science.gov (United States)

    Labonne, Gaëlle; Navarro, Nicolas; Laffont, Rémi; Chateau-Smith, Carmela; Montuire, Sophie

    2014-01-01

    The evolution of mammalian dentition is constrained by functional necessity and by the non-independence of morphological structures. Efficient chewing implies coherent tooth coordination from development to motion, involving covariation patterns (integration) within dental parts. Using geometric morphometrics, we investigate the modular organization of the highly derived vole dentition. Integration patterns between and within the upper and lower molar rows are analyzed to identify potential modules and their origins (functional and developmental). Results support an integrated adult dentition pattern for both developmental and functional aspects. The integration patterns between opposing molar pairs suggest a transient role for the second upper and lower molars during the chewing motion. Upper and lower molar rows form coherent units but the relative integration of molar pairs is in contradiction with existing developmental models. Emphasis on the first three cusps to grow leads to a very different integration pattern, which would be congruent with developmental models. The early developmental architecture of traits is masked by later stages of growth, but may still be deciphered from the adult phenotype, if careful attention is paid to relevant features.

  12. The Relationship between Manufacturing Integration and Performance from an Activity-Oriented Perspective

    Directory of Open Access Journals (Sweden)

    Ely Laureano Paiva

    2011-10-01

    Full Text Available Manufacturing integration with other functional areas and suppliers is a key aspect for achieving sustainable competitive advantage. The objective of this study is to analyze manufacturing integration from an activity-based perspective. We hypothesize that manufacturing integration with suppliers, marketing, and R&D is positively related to profit and sales growth when it occurs simultaneously in key internal activities. We surveyed 366 companies located in the southern region of Brazil, chosen from the SEBRAE(1 database. We used structural equations modeling to address validity and reliability issues. We evaluated common method variance (CMV with the MTMM model and used path analysis to test the structural relations. We found that all manufacturing integration aspects are positively related to sales growth, but only manufacturing-R&D integration is positively related to profitability. Therefore, managers interested in improving the performance of their plants should favor the integration between manufacturing and R&D teams, at all hierarchical levels. We did not find any evidence, however, that direct interaction between manufacturing and marketing improves performance.

  13. A self-aligned nano-fabrication process for vertical NbN-MgO-NbN Josephson junctions

    Science.gov (United States)

    Grimm, A.; Jebari, S.; Hazra, D.; Blanchet, F.; Gustavo, F.; Thomassin, J.-L.; Hofheinz, M.

    2017-10-01

    We present a new process for fabricating vertical NbN-MgO-NbN Josephson junctions using self-aligned silicon nitride spacers. It allows for a wide range of junction areas from 0.02 to several 100 μm2. At the same time, it is suited for the implementation of complex microwave circuits with transmission line impedances ranging from 1 {{k}}{{Ω }}. The constituent thin films and the finished junctions are characterized. The latter are shown to have high gap voltages (> 4 {mV}) and low sub-gap leakage currents.

  14. Focused ion beam damage to MOS integrated circuits

    Energy Technology Data Exchange (ETDEWEB)

    FLEETWOOD,D.M.; CAMPBELL,ANN N.; HEMBREE,CHARLES E.; TANGYUNYONG,PAIBOON; JESSING,JEFFREY R.; SODEN,JERRY M.

    2000-05-10

    Commercial focused ion beam (FIB) systems are commonly used to image integrated circuits (ICS) after device processing, especially in failure analysis applications. FIB systems are also often employed to repair faults in metal lines for otherwise functioning ICS, and are being evaluated for applications in film deposition and nanofabrication. A problem that is often seen in FIB imaging and repair is that ICS can be damaged during the exposure process. This can result in degraded response or out-right circuit failure. Because FIB processes typically require the surface of an IC to be exposed to an intense beam of 30--50 keV Ga{sup +} ions, both charging and secondary radiation damage are potential concerns. In previous studies, both types of effects have been suggested as possible causes of device degradation, depending on the type of device examined and/or the bias conditions. Understanding the causes of this damage is important for ICS that are imaged or repaired by a FIB between manufacture and operation, since the performance and reliability of a given IC is otherwise at risk in subsequent system application. In this summary, the authors discuss the relative roles of radiation damage and charging effects during FIB imaging. Data from exposures of packaged parts under controlled bias indicate the possibility for secondary radiation damage during FIB exposure. On the other hand, FIB exposure of unbiased wafers (a more common application) typically results in damage caused by high-voltage stress or electrostatic discharge. Implications for FIB exposure and subsequent IC use are discussed.

  15. Peptides derived from HIV-1 integrase that bind Rev stimulate viral genome integration.

    Directory of Open Access Journals (Sweden)

    Aviad Levin

    Full Text Available BACKGROUND: The human immunodeficiency virus type 1 (HIV-1 integrase protein (IN, catalyzes the integration of viral DNA into the host cell genome. IN catalyzes the first step of the integration process, namely the 3'-end processing in which IN removes a pGT dinucleotide from the 3' end of each viral long terminal repeat (LTR. Following nuclear import of the viral preintegration complex, the host chromosomal DNA becomes accessible to the viral cDNA and the second step of the integration process, namely the strand-transfer step takes place. This ordered sequence of events, centered on integration, is mandatory for HIV replication. METHODOLOGY/PRINCIPAL FINDINGS: Using an integrase peptide library, we selected two peptides, designated INr-1 and INr-2, which interact with the Rev protein and probably mediate the Rev-integrase interaction. Using an in-vitro assay system, we show that INr-1 and INr-2 are able to abrogate the inhibitory effects exerted by Rev and Rev-derived peptides on integrase activity. Both INr-1 and INr-2 were found to be cell-permeable and nontoxic, allowing a study of their effect in HIV-1-infected cultured cells. Interestingly, both INr peptides stimulated virus infectivity as estimated by production of the viral P24 protein, as well as by determination of the appearance of newly formed virus particles. Furthermore, kinetics studies revealed that the cell-permeable INr peptides enhance the integration process, as was indeed confirmed by direct determination of viral DNA integration by real-time PCR. CONCLUSIONS/SIGNIFICANCE: The results of the present study raise the possibility that in HIV-infected cells, the Rev protein may be involved in the integration of proviral DNA by controlling/regulating the activity of the integrase. Release from such inhibition leads to stimulation of IN activity and multiple viral DNA integration events.

  16. The Integration of MEPs from Central and Eastern Europe into the European Parliament

    Directory of Open Access Journals (Sweden)

    Radko Hokovský

    2012-04-01

    Full Text Available This article evaluates the level of integration of Members of the European Parliament from Central and Eastern Europe in the European Parliament after the EU enlargements of 2004 and 2007. The main objective is to address the puzzle of how the European Parliament’s political groups could maintain or even increase their voting cohesion after the influx of a significantly large number of new MEPs coming from countries with different historical experience, socio-economic characteristics, and political and party systems. Three indicators of MEP integration are defined: integration into parliamentary leadership, integration into parliamentary work, and integration into voting patterns. The article uses data from the VoteWatch.eu website on MEPs’ activities and voting between the years 2004-2011, as well as data from official documents of the European Parliament and its political groups. Analysis of the data reveals that the new member states’ MEPs were significantly under-represented in parliamentary leadership and key legislative activities, despite the fact that their voting loyalty to their political groups was greater than that of their colleagues from older member states.

  17. Hybrid plasmon photonic crystal resonance grating for integrated spectrometer biosensor.

    Science.gov (United States)

    Guo, Hong; Guo, Junpeng

    2015-01-15

    Using nanofabricated hybrid metal-dielectric nanohole array photonic crystal gratings, a hybrid plasmonic optical resonance spectrometer biosensor is demonstrated. The new spectrometer sensor technique measures plasmonic optical resonance from the first-order diffraction rather than via the traditional method of measuring optical resonance from transmission. The resonance spectra measured with the new spectrometer technique are compared with the spectra measured using a commercial optical spectrometer. It is shown that the new optical resonance spectrometer can be used to measure plasmonic optical resonance that otherwise cannot be measured with a regular optical spectrometer.

  18. Can service integration work for universal health coverage? Evidence from around the globe.

    Science.gov (United States)

    Lê, Gillian; Morgan, Rosemary; Bestall, Janine; Featherstone, Imogen; Veale, Thomas; Ensor, Tim

    2016-04-01

    Universal health coverage (UHC) is at the heart of the new 2030 Agenda for Sustainable Development. Health service integration is seen by World Health Organization as an essential requirement to achieve UHC. However, to date the debate on service integration has focused on perceived benefits rather than empirical impact. We conducted a global review in a systematic manner searching for empirical outcomes of service integration experiments in UHC countries and those on the path to UHC. Sixty-seven articles and reports were found. We grouped results into a unique integration typology with six categories - medical staff from different disciplines; patients and medical staff; care package for one medical condition; care package for two or more medical conditions; specialist stand-alone services with GP services; community locations. We showed that it is possible to integrate services in different human development contexts delivering positive outcomes for patients and clinicians without incurring additional costs. However, the improved outcomes shown were incremental rather than radical and suggest that integration is likely to enhance already well established systems rather than fundamentally changing the outcomes of care.

  19. Thermalization away from integrability and the role of operator off-diagonal elements.

    Science.gov (United States)

    Konstantinidis, N P

    2015-05-01

    We investigate the rate of thermalization of local operators in the one-dimensional anisotropic antiferromagnetic Heisenberg model with next-nearest neighbor interactions that break integrability. This is done by calculating the scaling of the difference of the diagonal and canonical thermal ensemble values as a function of system size, and by directly calculating the time evolution of the expectation values of the operators with the Chebyshev polynomial expansion. Spatial and spin symmetry is exploited and the Hamiltonian is divided into subsectors according to their symmetry. The rate of thermalization depends on the proximity to the integrable limit. When integrability is weakly broken thermalization is slow, and becomes faster the stronger the next-nearest neighbor interaction is. Three different regimes for the rate of thermalization with respect to the strength of the integrability breaking parameter are identified. These are shown to be directly connected with the relative strength of the low and higher energy difference off-diagonal operator matrix elements in the symmetry eigenbasis of the Hamiltonian. Close to the integrable limit the off-diagonal matrix elements peak at higher energies and high-frequency fluctuations are important and slow down thermalization. Away from the integrable limit a strong low-energy peak gradually develops that takes over the higher frequency fluctuations and leads to quicker thermalization.

  20. Brain network analysis: separating cost from topology using cost-integration.

    Directory of Open Access Journals (Sweden)

    Cedric E Ginestet

    Full Text Available A statistically principled way of conducting brain network analysis is still lacking. Comparison of different populations of brain networks is hard because topology is inherently dependent on wiring cost, where cost is defined as the number of edges in an unweighted graph. In this paper, we evaluate the benefits and limitations associated with using cost-integrated topological metrics. Our focus is on comparing populations of weighted undirected graphs that differ in mean association weight, using global efficiency. Our key result shows that integrating over cost is equivalent to controlling for any monotonic transformation of the weight set of a weighted graph. That is, when integrating over cost, we eliminate the differences in topology that may be due to a monotonic transformation of the weight set. Our result holds for any unweighted topological measure, and for any choice of distribution over cost levels. Cost-integration is therefore helpful in disentangling differences in cost from differences in topology. By contrast, we show that the use of the weighted version of a topological metric is generally not a valid approach to this problem. Indeed, we prove that, under weak conditions, the use of the weighted version of global efficiency is equivalent to simply comparing weighted costs. Thus, we recommend the reporting of (i differences in weighted costs and (ii differences in cost-integrated topological measures with respect to different distributions over the cost domain. We demonstrate the application of these techniques in a re-analysis of an fMRI working memory task. We also provide a Monte Carlo method for approximating cost-integrated topological measures. Finally, we discuss the limitations of integrating topology over cost, which may pose problems when some weights are zero, when multiplicities exist in the ranks of the weights, and when one expects subtle cost-dependent topological differences, which could be masked by cost-integration.

  1. Analysis of Far-Field Radiation from Apertures Using Monte Carlo Integration Technique

    Directory of Open Access Journals (Sweden)

    Mohammad Mehdi Fakharian

    2014-12-01

    Full Text Available An integration technique based on the use of Monte Carlo Integration (MCI is proposed for the analysis of the electromagnetic radiation from apertures. The technique that can be applied to the calculation of the aperture antenna radiation patterns is the equivalence principle followed by physical optics, which can then be used to compute far-field antenna radiation patterns. However, this technique is often complex mathematically, because it requires integration over the closed surface. This paper presents an extremely simple formulation to calculate the far-fields from some types of aperture radiators by using MCI technique. The accuracy and effectiveness of this technique are demonstrated in three cases of radiation from the apertures and results are compared with the solutions using FE simulation and Gaussian quadrature rules.

  2. Facilitating Dance Making from a Teacher's Perspective within a Community Integrated Dance Class

    Science.gov (United States)

    Cheesman, Sue

    2011-01-01

    Integrated dance has featured in several publications from the mid-1990's onwards, particularly from the standpoints of equity of access, and contesting perceptions of dominant conventional notions of what dance is and who can dance including issues of embodiment and representation. Other publications and manuals focus primarily on how to teach…

  3. Assessment of the integration capability of system architectures from a complex and distributed software systems perspective

    Science.gov (United States)

    Leuchter, S.; Reinert, F.; Müller, W.

    2014-06-01

    Procurement and design of system architectures capable of network centric operations demand for an assessment scheme in order to compare different alternative realizations. In this contribution an assessment method for system architectures targeted at the C4ISR domain is presented. The method addresses the integration capability of software systems from a complex and distributed software system perspective focusing communication, interfaces and software. The aim is to evaluate the capability to integrate a system or its functions within a system-of-systems network. This method uses approaches from software architecture quality assessment and applies them on the system architecture level. It features a specific goal tree of several dimensions that are relevant for enterprise integration. These dimensions have to be weighed against each other and totalized using methods from the normative decision theory in order to reflect the intention of the particular enterprise integration effort. The indicators and measurements for many of the considered quality features rely on a model based view on systems, networks, and the enterprise. That means it is applicable to System-of-System specifications based on enterprise architectural frameworks relying on defined meta-models or domain ontologies for defining views and viewpoints. In the defense context we use the NATO Architecture Framework (NAF) to ground respective system models. The proposed assessment method allows evaluating and comparing competing system designs regarding their future integration potential. It is a contribution to the system-of-systems engineering methodology.

  4. Integration of Metagenomic and Biogeochemical Data from Soils Sampled from a Long-Term Reciprocal Transplant

    Science.gov (United States)

    Bailey, V. L.; Hess, N. J.; McCue, L. A.

    2014-12-01

    The long-term impacts of climate conditions on soil ecosystems are difficult to discern with sufficient resolution to underpin a predictive understanding of ecosystem response to global climate change. The structure and function of the microbial community is intimately linked to soil organic carbon (SOC) by both the deposition of new carbon, and metabolism and respiration of existing SOC. We are studying the resilience of the microbial community, and the vulnerability of the soil carbon reservoirs, to changing climate conditions using a reciprocal soil transplant experiment initiated in 1994 in eastern Washington. Soil cores were reciprocally transplanted between two elevations (310 m and 844 m); the lower site is warmer and drier with 0.8% soil carbon, and the upper site is cooler and wetter with 1.8% soil carbon. We resampled these cores in 2012-13 to analyze the structure of the microbial community, biochemical activities of carbohydrate-active enzymes, and the soil carbon and nitrogen content. We hypothesized that microbial and biochemical dynamics developed under cool, moist conditions would destabilize under hot, dry conditions, such that carbon and nitrogen losses would be faster in warmer climate soils than the accruals in cooler climate soils. Metagenomics data analyses show that the microbial communities below 5 cm depth in the transplanted soils are most similar to those in the native and control soils from their original (pre-1994) location, whereas the surface microbial community has been influenced by their new (post-1994) location. Enzyme activities are highest in soils from the cooler, moister location, and the activities of the reciprocally transplanted soils are shifting toward the activities typical of their new location. Integration of these results with high-resolution mass spectrometry data of the soil carbon moieties will contribute to our fundamental understanding of climate change effects on the terrestrial ecosystem carbon cycle.

  5. Nano-Fabrication Methods for Micro-Miniature Optical Thermometers Suited to High Temperatures and Harsh Environments

    Science.gov (United States)

    DePew, K. A.; Ma, C.; Schiffbauer, J. D.; Wang, J.; Dong, B.; Lally, E.; Wang, A.

    2012-12-01

    The Center for Photonics Technology (CPT) at Virginia Tech is engaged in cutting edge research of fiber optic sensing technologies. One current research area is the design of fiber optic temperature sensors for harsh environments. Fiber optic temperature sensing offers significant advantages over electronic sensing in terms of size and insensitivity to harsh environmental conditions and electromagnetic interference. In the field, fiber optic thermometers have been used in recent snow cover studies as well as fluvial temperature profiling projects. The extended capabilities of CPT optical sensors open further possibilities for application in additional geologic realms requiring high temperature sensing in corrosive environments. Significant strides have been made in developing single-crystal sapphire based fiber optic sensing elements for high temperature environments which are otherwise difficult to instrument. Utilization of strain insensitive designs and optical sapphire materials allow for thermometers capable of operation above 1500°C with reduced sensitivity to chemical corrosion and mechanical interference. Current efforts in fabrication techniques are reducing the footprint of temperature sensors below the millimeter scale while maintaining high resolution and operating range. The FEI Helios 600 NanoLab workstation at the Virginia Tech Institute for Critical Technologies and Applied Science has been employed, providing the capabilities necessary to reduce the footprint of sensing elements to the dimensions of standard optical communication fiber using a Ga+ focused ion beam (FIB). The capability of semi-distributed multi-point sensing can also be accomplished at this scale using similar FIB milling techniques. The fiber optic thermometer designs resulting from these methods are compact, lightweight, and able to provide remote sensing without need for electrical power at the measurement point. These traits make them an ideal sensing platform for laboratory

  6. Robust integral formulations for electromagnetic scattering from three-dimensional cavities

    Science.gov (United States)

    Lai, Jun; Greengard, Leslie; O'Neil, Michael

    2017-09-01

    Scattering from large, open cavity structures is of importance in a variety of electromagnetic applications. In this paper, we propose a new well conditioned integral equation for scattering from general open cavities embedded in an infinite, perfectly conducting half-space. The integral representation permits the stable evaluation of both the electric and magnetic field, even in the low-frequency regime, using the continuity equation in a post-processing step. We establish existence and uniqueness results, and demonstrate the performance of the scheme in the cavity-of-revolution case. High-order accuracy is obtained using a Nyström discretization with generalized Gaussian quadratures.

  7. Decentralized identification for multivariable integrating processes with time delays from closed-loop step tests.

    Science.gov (United States)

    Mei, Hua; Li, Shaoyuan

    2007-04-01

    In order to identify those multivariable processes with integrating factors in their transfer function matrices, a simple yet robust decentralized identification method from closed-loop step tests is proposed. By the frequency response matrix computed from the closed-loop system data and the knowledge of the decentralized controller, the structural information of the multivariable integrating process is determined firstly and then the continuous parametric model with dead times is approximated similarly with the parameterization of the open-loop stable process. Computer simulations and an application to a 3 x 3 integrating multiple-tank water level system verify the validation of the proposed method even if the closed-loop system is affected by some stochastic noise sources.

  8. Integration of Lean and Agile Manufacturing Based on Principles from Wikinomics

    Directory of Open Access Journals (Sweden)

    Tatiana Ustyugová

    2013-07-01

    Full Text Available The purporse of this paper is to show the algorithm of the lean and agile manufacturing integration based on the principles from Wikinomics, which will lead to a steady production process and easier growth of company’s success. Lean and agile manufacturing are production concepts, which become more and more popular at the modern market. Nowadays we live at the period of possible, global communication, where the success of companies depends on customers’ satisfaction and the correct cost management. Therefore the principles from Wikinomics can be used like as integration method of lean and agile manufacturing. The originality of this paper lies in the creation of the new general algorithm of the lean and agile manufacturing integration was created, which will be used for the future research with special limitations of the Czech market. 

  9. Total and Direct Correlation Function Integrals from Molecular Simulation of Binary Systems

    DEFF Research Database (Denmark)

    Wedberg, Nils Hejle Rasmus Ingemar; O’Connell, John P.; Peters, Günther H.J.

    2011-01-01

    The possibility for obtaining derivative properties for mixtures from integrals of spatial total and direct correlation functions obtained from molecular dynamics simulations is explored. Theoretically well-supported methods are examined to extend simulation radial distribution functions to long...... range so the integrals can converge. A previously published method developed for pure atomic fluids is here extended to handle simulations of molecular mixtures using all-atom force fields. We first test the method on simulations of Lennard-Jones/Stockmayer mixtures and show that that the results...... are consistent with an excess Helmholtz energy model fitted to available simulations. In addition, simulations of water/methanol and water/t-butanol mixtures have been carried out. The method yields results for partial molar volumes, activity coefficient derivatives, and individual correlation function integrals...

  10. Integrating Variable Renewable Energy in Electric Power Markets: Best Practices from International Experience (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    2014-10-01

    Many countries--reflecting very different geographies, markets, and power systems--are successfully managing high levels of variable renewable energy (RE) on the grid. Australia (South Australia), Denmark, Germany, Ireland, Spain, and the United States (Colorado and Texas), for example, have effectively integrated variable RE utilizing diverse approaches. Analysis of the results from these case studies reveals a wide range of mechanisms that can be used to accommodate high penetrations of variable RE (e.g., from new market designs to centralized planning). Nevertheless, the myriad approaches collectively suggest that governments can best enable variable RE grid integration by implementing best practices in five areas of intervention: lead public engagement, particularly for new transmission; coordinate and integrate planning; develop rules for market evolution that enable system flexibility; expand access to diverse resources and geographic footprint of operations; and improve system operations.

  11. Infrared High-resolution Integrated Light Spectral Analyses of M31 Globular Clusters from APOGEE

    Science.gov (United States)

    Sakari, Charli M.; Shetrone, Matthew D.; Schiavon, Ricardo P.; Bizyaev, Dmitry; Allende Prieto, Carlos; Beers, Timothy C.; Caldwell, Nelson; Aníbal García-Hernández, Domingo; Lucatello, Sara; Majewski, Steven; O'Connell, Robert W.; Pan, Kaike; Strader, Jay

    2016-10-01

    Chemical abundances are presented for 25 M31 globular clusters (GCs), based on moderately high resolution (R = 22,500) H-band integrated light (IL) spectra from the Apache Point Observatory Galactic Evolution Experiment (APOGEE). Infrared (IR) spectra offer lines from new elements, lines of different strengths, and lines at higher excitation potentials compared to the optical. Integrated abundances of C, N, and O are derived from CO, CN, and OH molecular features, while Fe, Na, Mg, Al, Si, K, Ca, and Ti abundances are derived from atomic features. These abundances are compared to previous results from the optical, demonstrating the validity and value of IR IL analyses. The CNO abundances are consistent with typical tip of the red giant branch stellar abundances but are systematically offset from optical Lick index abundances. With a few exceptions, the other abundances agree between the optical and the IR within the 1σ uncertainties. The first integrated K abundances are also presented and demonstrate that K tracks the α elements. The combination of IR and optical abundances allows better determinations of GC properties and enables probes of the multiple populations in extragalactic GCs. In particular, the integrated effects of the Na/O anticorrelation can be directly examined for the first time.

  12. Demand-Side Management and Integrated Resource Planning: Findings from a Survey of 24 Electric Utilities

    Energy Technology Data Exchange (ETDEWEB)

    Schweitzer, M.

    1991-01-01

    Integrated resource planning differs from traditional utility planning practices primarily in its increased attention to demand-side management (DSM) programs and its integration of supply- and demand-side resources into a combined resource portfolio. This report details the findings from an Oak Ridge National Laboratory (ORNL) survey of 24 electric utilities that have well-developed integrated planning processes. These utilities account for roughly one-third of total capacity, electricity generation, and DSM-program expenditures nationwide. The ORNL survey was designed to obtain descriptive data on a national sample of utilities and to test a number of hypothesized relationships between selected utility characteristics and the mix of resources selected for the integrated plan, with an emphasis on the use of DSM resources and the processes by which they are chosen. The survey solicited information on each utility's current and projected resource mix, operating environment, procedures used to screen potential DSM resources, techniques used to obtain public input and to integrate supply- and demand-side options into a unified plan, and procedures used in the final selection of resources for the plan.

  13. Flexible and low-voltage integrated circuits constructed from high-performance nanocrystal transistors.

    Science.gov (United States)

    Kim, David K; Lai, Yuming; Diroll, Benjamin T; Murray, Christopher B; Kagan, Cherie R

    2012-01-01

    Colloidal semiconductor nanocrystals are emerging as a new class of solution-processable materials for low-cost, flexible, thin-film electronics. Although these colloidal inks have been shown to form single, thin-film field-effect transistors with impressive characteristics, the use of multiple high-performance nanocrystal field-effect transistors in large-area integrated circuits has not been shown. This is needed to understand and demonstrate the applicability of these discrete nanocrystal field-effect transistors for advanced electronic technologies. Here we report solution-deposited nanocrystal integrated circuits, showing nanocrystal integrated circuit inverters, amplifiers and ring oscillators, constructed from high-performance, low-voltage, low-hysteresis CdSe nanocrystal field-effect transistors with electron mobilities of up to 22 cm(2) V(-1) s(-1), current modulation >10(6) and subthreshold swing of 0.28 V dec(-1). We fabricated the nanocrystal field-effect transistors and nanocrystal integrated circuits from colloidal inks on flexible plastic substrates and scaled the devices to operate at low voltages. We demonstrate that colloidal nanocrystal field-effect transistors can be used as building blocks to construct complex integrated circuits, promising a viable material for low-cost, flexible, large-area electronics.

  14. DNA Based Molecular Scale Nanofabrication

    Science.gov (United States)

    2015-12-04

    water adsorption on DNA origami template and its impact on DNA- mediated chemical reactions. We also extended the concept of DNA- mediated reaction to...addition, we have expanded our efforts to include DNA- mediated HF etching of SiÜ2, DNA- mediated nanoimprinting lithography, DNA-based patterning of self...detailed kinetics study of DNA- mediated chemical reactions. Examples of such reactions include chemical vapor deposition (CVD) of inorganic oxide and HF

  15. Nanofabrication by Focused Ion Beam

    Science.gov (United States)

    1993-09-28

    MASTER COPY KEEP THIS COPY FOR REPRODUCTION PURPOSES AD-A271 290 )N PAGE orhan Sand .01fMI.,r re ~’.nq tn., Oiurda N0o.me 0& Of .018l 04v~~t P - .L...Institute of Technology Cambridge, MA 02139 APPROVED FOR PUBLIC RELEASE; N, S c; . DISTRIBUTION UNLIMITED u..d.. `. B y .. . . . . . .. Dist A-jr I...defined sidewalls indicate that much finer lithography would be possible with a1 more optimum beam. b ) Preferential Oxide growth after ion exposure. (In

  16. Learning From The Socio-Religious Integration In Solor Village Indonesia

    Directory of Open Access Journals (Sweden)

    Irene Ludji

    2015-06-01

    Full Text Available The Indonesian nation with the motto “Bhineka Tunggal Ika” (Unity in Diversity is a nation that believes in the beauty of pluralism as the primary model to build unity. Therefore, in building relationships that produce social integration, it should be characterized by acceptance and respect of pluralism and a willingness to learn from this pluralism. Unfortunately, the increasing number of conflicts results in the inability of society to tolerate differences, as seen in the nation’s self-identity becoming unstable. It is clear that the national identity needs to be reinforced through strategic steps that are systematic, clear-cut, and integrated, so that the national unity can be strongly united again. One of the ways to accomplish this is by learning from social integration that occurs in various locations in Indonesia. One such place is in Solor Village, Kupang.  In the midst of various conflicts that center on ethnic groups, race, religion, and class issues in Indonesia, the relationship between the indigenous people and newcomers in Solor Village offers an alternative for social integration that can occur in this “Unity in Diversity” nation. This is the focus of this research, which uses a descriptive-qualitative format to analyze social integration strategic issues between newcomers with different religious and cultural backgrounds from the native inhabitants of Solor Village. The research shows that Solor Village residents succeed in building a harmonious life because in facing multiculturalism, religious and cultural values play an important role.Harmonious life in Solor Village confirm that social integration that build on respect to pluralism is possible.

  17. From integrative genomics to systems genetics in the rat to link genotypes to phenotypes

    Science.gov (United States)

    Moreno-Moral, Aida

    2016-01-01

    ABSTRACT Complementary to traditional gene mapping approaches used to identify the hereditary components of complex diseases, integrative genomics and systems genetics have emerged as powerful strategies to decipher the key genetic drivers of molecular pathways that underlie disease. Broadly speaking, integrative genomics aims to link cellular-level traits (such as mRNA expression) to the genome to identify their genetic determinants. With the characterization of several cellular-level traits within the same system, the integrative genomics approach evolved into a more comprehensive study design, called systems genetics, which aims to unravel the complex biological networks and pathways involved in disease, and in turn map their genetic control points. The first fully integrated systems genetics study was carried out in rats, and the results, which revealed conserved trans-acting genetic regulation of a pro-inflammatory network relevant to type 1 diabetes, were translated to humans. Many studies using different organisms subsequently stemmed from this example. The aim of this Review is to describe the most recent advances in the fields of integrative genomics and systems genetics applied in the rat, with a focus on studies of complex diseases ranging from inflammatory to cardiometabolic disorders. We aim to provide the genetics community with a comprehensive insight into how the systems genetics approach came to life, starting from the first integrative genomics strategies [such as expression quantitative trait loci (eQTLs) mapping] and concluding with the most sophisticated gene network-based analyses in multiple systems and disease states. Although not limited to studies that have been directly translated to humans, we will focus particularly on the successful investigations in the rat that have led to primary discoveries of genes and pathways relevant to human disease. PMID:27736746

  18. Responses to GM food content in context with food integrity issues: results from Australian population surveys.

    Science.gov (United States)

    Mohr, Philip; Golley, Sinéad

    2016-01-25

    This study examined community responses to use of genetically modified (GM) content in food in the context of responses to familiar food additives by testing an empirically and theoretically derived model of the predictors of responses to both GM content and food integrity issues generally. A nationwide sample of 849 adults, selected at random from the Australian Electoral Roll, responded to a postal Food and Health Survey. Structural equation modelling analyses confirmed that ratings of general concern about food integrity (related to the presence of preservatives and other additives) strongly predicted negativity towards GM content. Concern about food integrity was, in turn, predicted by environmental concern and health engagement. In addition, both concern about food integrity generally and responses to GM content specifically were weakly predicted by attitudes to benefits of science and an intuitive (i.e., emotionally-based) reasoning style. Data from a follow-up survey conducted under the same conditions (N=1184) revealed that ratings of concern were significantly lower for use of genetic engineering in food than for four other common food integrity issues examined. Whereas the question of community responses to GM is often treated as a special issue, these findings support the conclusion that responses to the concept of GM content in food in Australia are substantially a specific instance of a general sensitivity towards the integrity of the food supply. They indicate that the origins of responses to GM content may be largely indistinguishable from those of general responses to preservatives and other common food additives. Copyright © 2015 Elsevier B.V. All rights reserved.

  19. Obtain Lower-Dimensional Turbulence Systems from Higher-Dimensional Lax Integrable Models

    Institute of Scientific and Technical Information of China (English)

    LOU Sen-Yue

    2001-01-01

    Taking the well known (1-+l)-dimensional turbulence system,the Korteweg de-Vries Burgers equation,as a special example,we show that some types of lower-dimensional turbulence systems may be derived from some higherdimensional Lax integrable models,say,the (2+1)-dimensional asymmetric Nizhnik-Novikov-Veselov equation.On the other hand,using the Lax pair of the original higher-dimensional integrable model(s),we may obtain higher-dimensional Lax pair(s) for a lower-dimensional turbulence system.``

  20. How to derive Feynman diagrams for finite-dimensional integrals directly from the BV formalism

    CERN Document Server

    Gwilliam, Owen

    2012-01-01

    The Batalin-Vilkovisky formalism in quantum field theory was originally invented to avoid the difficult problem of finding diagrammatic descriptions of oscillating integrals with degenerate critical points. But since then, BV algebras have become interesting objects of study in their own right, and mathematicians sometimes have good understanding of the homological aspects of the story without any access to the diagrammatics. In this note we reverse the usual direction of argument: we begin by asking for an explicit calculation of the homology of a BV algebra, and from it derive Wick's Theorem and the other Feynman rules for finite-dimensional integrals.

  1. Economic integration in North America: Learning from the experience of the European Union for the NAFTA

    Directory of Open Access Journals (Sweden)

    Ramón de Jesús Ramírez Acosta

    2009-01-01

    Full Text Available In this document we analyze, based on previous work from various authors, the degree of economic synchronization between Central and Eastern European countries and the European Union prior to the 2004 adhesion treaties. Then, we formally determine the degree of economic synchronization in North America for the nafta transitional period. In particular, we perform cointegration and common features tests for the gdps of Canada, Mexico and the US. We find that the economies of the region are highly integrated. Based on these results, and the facts identified for the European case, we discuss some possibilities for the evolution of nafta into a deeper form of economic integration.

  2. Time-Domain Volume Integral Equation for TM-Case Scattering from Nonlinear Penetrable Objects

    Institute of Scientific and Technical Information of China (English)

    WANG Jianguo; Eric Michielssen

    2001-01-01

    This paper presents the time-domainvolume integral equation (TDVIE) method to analyzescattering from nonlinear penetrable objects, whichare illuminated by the transverse magnetic (TM) in-cident pulse. The time-domain volume integral equa-tion is formulated in terms of two-dimensional (2D)Green's function, and solved by using the march-on-in time (MOT) technique. Some numerical results aregiven to validate this method, and comparisons aremade with the results obtained by using the finite-difference time-domain (FDTD) method.

  3. Integration and Typologies of Vulnerability to Climate Change: A Case Study from Australian Wheat Sheep Zones.

    Science.gov (United States)

    Huai, Jianjun

    2016-09-27

    Although the integrated indicator methods have become popular for assessing vulnerability to climate change, their proliferation has introduced a confusing array of scales and indicators that cause a science-policy gap. I argue for a clear adaptation pathway in an "integrative typology" of regional vulnerability that matches appropriate scales, optimal measurements and adaptive strategies in a six-dimensional and multi-level analysis framework of integration and typology inspired by the "5W1H" questions: "Who is concerned about how to adapt to the vulnerability of what to what in some place (where) at some time (when)?" Using the case of the vulnerability of wheat, barley and oats to drought in Australian wheat sheep zones during 1978-1999, I answer the "5W1H" questions through establishing the "six typologies" framework. I then optimize the measurement of vulnerability through contrasting twelve kinds of vulnerability scores with the divergence of crops yields from their regional mean. Through identifying the socioeconomic constraints, I propose seven generic types of crop-drought vulnerability and local adaptive strategy. Our results illustrate that the process of assessing vulnerability and selecting adaptations can be enhanced using a combination of integration, optimization and typology, which emphasize dynamic transitions and transformations between integration and typology.

  4. From use cases of the Joint European Torus towards integrated commissioning requirements of the ITER tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Neto, A.C. [Fusion for Energy, 08019 Barcelona (Spain); Stephen, A. [CCFE, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Sartori, F.; Cavinato, M. [Fusion for Energy, 08019 Barcelona (Spain); Farthing, J.W. [CCFE, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Ranz, R.; Saibene, G. [Fusion for Energy, 08019 Barcelona (Spain); Winter, A. [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul Lez Durance Cedex (France); Arnoux, G. [CCFE, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Alves, D. [Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa (Portugal); Blackman, T.; Boboc, A.; Card, P.J.; Dalley, S.; Day, I.E. [CCFE, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); De Tommasi, G. [Consorzio CREATE/Dipartimento di Ingegneria Elettrica e delle Tecnologie dell’Informazione, Università degli Studi di Napoli Federico II, Via Claudio 21, 80125 Napoli (Italy); Drewelow, P.; Elsmore, C.; Ivings, E.; Felton, R. [CCFE, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); and others

    2015-10-15

    The Joint European Torus (JET) is the largest tokamak currently in operation in the world. One of the greatest challenges of JET is the integrated commissioning of all its major plant systems. This is driven, partially, by the size and complexity of its operational infrastructure and also by the fact that, being an international environment, it has to address the issues of integrating, commissioning and maintaining plant systems developed by third parties. The ITER tokamak, now in construction, is a fusion device twice the size of JET and, being a joint effort between the European Union, China, India, Japan, South Korea, the Russian Federation and the USA, it will share on a wider scale all of the JET challenges regarding integration and integrated commissioning of very large and complex plant systems. With the scope of taking advantage from the history and experience of JET, Fusion for Energy (F4E) has worked together with the Culham Centre for Fusion Energy (CCFE), the host and operator of JET, for the provision of ITER relevant user experiences related to the integrated commissioning of the tokamak. This work presents and discusses the main results and the methods that were used to extract and translate the commissioning experience information into ITER requirements.

  5. Integration and Typologies of Vulnerability to Climate Change: A Case Study from Australian Wheat Sheep Zones

    Science.gov (United States)

    Huai, Jianjun

    2016-09-01

    Although the integrated indicator methods have become popular for assessing vulnerability to climate change, their proliferation has introduced a confusing array of scales and indicators that cause a science-policy gap. I argue for a clear adaptation pathway in an “integrative typology” of regional vulnerability that matches appropriate scales, optimal measurements and adaptive strategies in a six-dimensional and multi-level analysis framework of integration and typology inspired by the “5W1H” questions: “Who is concerned about how to adapt to the vulnerability of what to what in some place (where) at some time (when)?” Using the case of the vulnerability of wheat, barley and oats to drought in Australian wheat sheep zones during 1978–1999, I answer the “5W1H” questions through establishing the “six typologies” framework. I then optimize the measurement of vulnerability through contrasting twelve kinds of vulnerability scores with the divergence of crops yields from their regional mean. Through identifying the socioeconomic constraints, I propose seven generic types of crop-drought vulnerability and local adaptive strategy. Our results illustrate that the process of assessing vulnerability and selecting adaptations can be enhanced using a combination of integration, optimization and typology, which emphasize dynamic transitions and transformations between integration and typology.

  6. Racial Integration and Learners from Limited Income Families--An Essay for American Educators.

    Science.gov (United States)

    Boyer, James B.

    The challenge of educating learners from limited-income families, combined with the challenge of racial integration in the schools, is discussed in this essay. Some learning problems among impoverished children are attributed to segregation, prejudice, and the class-caste system. The inadequacies of segregated schools serving minority groups as…

  7. Ontology-based data integration from heterogeneous urban systems: A knowledge representation framework for smart cities

    NARCIS (Netherlands)

    Psyllidis, A.

    2015-01-01

    This paper presents a novel knowledge representation framework for smart city planning and management that enables the semantic integration of heterogeneous urban data from diverse sources. Currently, the combination of information across city agencies is cumbersome, as the increasingly available da

  8. Quantitative and qualitative proteome characteristics extracted from in-depth integrated genomics and proteomics analysis

    NARCIS (Netherlands)

    Low, T.Y.; van Heesch, S.; van den Toorn, H.; Giansanti, P.; Cristobal, A.; Toonen, P.; Schafer, S.; Hubner, N.; van Breukelen, B.; Mohammed, S.; Cuppen, E.; Heck, A.J.R.; Guryev, V.

    2013-01-01

    Quantitative and qualitative protein characteristics are regulated at genomic, transcriptomic, and posttranscriptional levels. Here, we integrated in-depth transcriptome and proteome analyses of liver tissues from two rat strains to unravel the interactions within and between these layers. We obtain

  9. Do Integrated Children's Services Improve Children's Outcomes?: Evidence from England's Children's Trust Pathfinders

    Science.gov (United States)

    O'Brien, Margaret; Bachmann, Max O.; Jones, Natalia R.; Reading, Richard; Thoburn, June; Husbands, Chris; Shreeve, Ann; Watson, Jacqueline

    2009-01-01

    Thirty-five children's trust pathfinders, local cross-sector partnerships, were introduced across England in 2003 to promote greater integration in children's services. Using administrative performance data, this paper tracks yearly trends in child service outputs and child well-being outcomes from 1997 to 2004 in these local areas, including the…

  10. From collision to collaboration - Integrating informal recyclers and re-use operators in Europe: A review.

    Science.gov (United States)

    Scheinberg, Anne; Nesić, Jelena; Savain, Rachel; Luppi, Pietro; Sinnott, Portia; Petean, Flaviu; Pop, Flaviu

    2016-09-01

    The European Union hosts some of the world's most developed waste management systems and an ambitious policy commitment to the circular economy. The existence of informal recycling and re-use activities in Europe has been vigorously denied until quite recently, and remains a very challenging subject for the European solid waste management sector, as well as for European government and private institutions. In countries ranging from Malta to Macedonia and from France to Turkey, informal recyclers excluded from legal recycling niches increasingly collide with formalised and controlled European Union approaches to urban waste management, packaging recovery schemes, formal re-use enterprises, and extended producer responsibility systems.This review focuses on the period from 2004 through the first half of 2016. The 78 sources on European (and neighbouring) informal recycling and re-use are contextualised with global sources and experience. The articles focus on informal recovery in and at the borders of the European Union, document the conflicts and collisions, and elaborate some constructive approaches towards legalisation, integration, and reconciliation. The overarching recommendation, to locate the issue of informal recovery and integration in the framework of the European circular economy package, is supported by four specific pillars of an integration strategy: Documentation, legalisation, occupational and enterprise recognition, and preparation for structural integration.

  11. Disciplinary integration into English teaching from the student’s perspective

    Institute of Scientific and Technical Information of China (English)

    汤熙; 姚烨

    2015-01-01

    This report is based on a survey of a Jiangsu college students innovation and entrepreneurship project which accessed858 respondent questionnaires and interviews with 46 students from 30 undergraduate programmes at 4 applied higher education institutions.The research aims to investigate university students’perception and anticipation of disciplinary integration into university English classrooms.

  12. Integrating conflicting information from multiple texts: Effects of prior attitudes and text format

    NARCIS (Netherlands)

    Van Strien, Johan; Brand-Gruwel, Saskia; Boshuizen, Els

    2011-01-01

    Van Strien, J. L. H., Brand-Gruwel, S., & Boshuizen, H. P. A. (2011, August). Integrating conflicting information from multiple texts: Effects of prior attitudes and text format. Round table session presented at the Junior Researchers pre-conference of the biannual meeting of the European Associatio

  13. 78 FR 22225 - Solicitation of Input From Stakeholders Regarding the Integrated Forest Products Research Program

    Science.gov (United States)

    2013-04-15

    ... National Institute of Food and Agriculture Solicitation of Input From Stakeholders Regarding the Integrated... Agriculture. ACTION: Notice of Request for Stakeholder Input. SUMMARY: As part of the National Institute of..., NIFA is soliciting stakeholder input that will allow it to identify the needs and opportunities of...

  14. INTEGRAL SPI Limits on Electron-Positron Annihilation Radiation from the Galactic Plane

    DEFF Research Database (Denmark)

    Teegarden, B. J.; Watanabe, K.; Jean, P.;

    2005-01-01

    ‐Ray Astrophysics Laboratory) mission, launched in 2002 October, is the detailed study of this radiation. The Spectrometer on INTEGRAL (SPI) is a high‐resolution, coded‐aperture gamma‐ray telescope with an unprecedented combination of sensitivity, angular resolution, and energy resolution. We report results from...

  15. Teaching for Civic Engagement: Lesson Learned from Integrating Positive Psychology and Future Studies

    Science.gov (United States)

    Allen, Jeanie K.

    2011-01-01

    Teaching for civic education holds promise for assisting colleges and universities that suggest the promotion of global citizenship in their mission statements. This paper presents the study of a course where readings and activities from the literature of positive psychology were integrated with studies about current global issues and potential…

  16. Understanding Introductory Students' Application of Integrals in Physics from Multiple Perspectives

    Science.gov (United States)

    Hu, Dehui

    2013-01-01

    Calculus is used across many physics topics from introductory to upper-division level college courses. The concepts of differentiation and integration are important tools for solving real world problems. Using calculus or any mathematical tool in physics is much more complex than the straightforward application of the equations and algorithms that…

  17. Integrating Corpus Work into Secondary Education: From Data-Driven Learning to Needs-Driven Corpora

    Science.gov (United States)

    Braun, Sabine

    2007-01-01

    This paper reports on an empirical case study conducted to investigate the overall conditions and challenges of integrating corpus materials and corpus-based learning activities into English-language classes at a secondary school in Germany. Starting from the observation that in spite of the large amount of research into corpus-based language…

  18. Lessons from the Desert: Integrating Managerial Expertise and Learning for Organizational Transformation

    Science.gov (United States)

    Roth, George

    2004-01-01

    Reflection upon a field study of a corporate transformation provides insights into the application and integration of organizational learning theory and frameworks with local, corporate knowledge. In the corporate transformation studied this local knowledge came from consumer psychology, marketing campaigns and the use of media. When these ideas…

  19. Conditionality of inverse solutions to discretised integral equations in geoid modelling from local gravity data

    NARCIS (Netherlands)

    Tenzer, R.; Novák, P.

    2008-01-01

    The eigenvalue decomposition technique is used for analysis of conditionality of two alternative solutions for a determination of the geoid from local gravity data. The first solution is based on the standard two-step approach utilising the inverse of the Abel-Poisson integral equation (downward

  20. INTEGRAL detection of renewed activity from the SFXT IGR J16479-4514

    Science.gov (United States)

    Fiocchi, M.; Lepingwell, V. A.; Bazzano, A.; Natalucci, L.; Ubertini, P.; Bird, A. J.; Kuulkers, Erik

    2017-02-01

    During a recent INTEGRAL public observation of the Norma region, performed between 2017-02-14 00:07:42 and 2017-02-14 08:49:44 (UTC), activity from the Supergiant Fast X-ray Transient (SFXT) IGR J16479-4514 has been detected.

  1. Integrable light-cone lattice discretizations from the universal R-matrix

    CERN Document Server

    Meneghelli, C

    2015-01-01

    Our goal is to develop a more general scheme for constructing integrable lattice regularisations of integrable quantum field theories. Considering the affine Toda theories as examples, we show how to construct such lattice regularisations using the representation theory of quantum affine algebras. This requires us to clarify in particular the relations between the light-cone approach to integrable lattice models and the representation theory of quantum affine algebras. Both are found to be related in a very natural way, suggesting a general scheme for the construction of generalised Baxter Q-operators. One of the main difficulties we need to deal with is coming from the infinite-dimensionality of the relevant families of representations. It is handled by means of suitable renormalisation prescriptions defining what may be called the modular double of quantum affine algebras. This framework allows us to give a representation-theoretic proof of finite-difference equations generalising the Baxter equation.

  2. Dynamic stability of the Solar System: Statistically inconclusive results from ensemble integrations

    CERN Document Server

    Zeebe, Richard E

    2015-01-01

    Due to the chaotic nature of the Solar System, the question of its long-term stability can only be answered in a statistical sense, for instance, based on numerical ensemble integrations of nearby orbits. Destabilization of the inner planets, leading to close encounters and/or collisions can be initiated through a large increase in Mercury's eccentricity, with a currently assumed likelihood of ~1%. However, little is known at present about the robustness of this number. Here I report ensemble integrations of the full equations of motion of the eight planets and Pluto over 5 Gyr, including contributions from general relativity. The results show that different numerical algorithms lead to statistically different results for the evolution of Mercury's eccentricity (eM). For instance, starting at present initial conditions (eM ~= 0.21), Mercury's maximum eccentricity achieved over 5 Gyr is on average significantly higher in symplectic ensemble integrations using heliocentricthan Jacobi coordinates and stricter er...

  3. ICT Integration in Accounting Education: Evidence from Two Private Higher Institutions in Nigeria

    Directory of Open Access Journals (Sweden)

    Oyebisi Mary Ogundana

    2015-12-01

    Full Text Available This study examined the role of ICT integration in accounting education on the value adding capacity of accounting students in Nigeria. The study adopted the Survey research design involving the collection of data from accounting students in selected private universities in Nigeria. Copies of Questionnaire were administered to 147 respondents out of which 111 were gathered. Pearson Correlation and Linear Regression were employed in the analysis of the data collected with the use of Statistical Packages for Social Sciences (SPSS. The results revealed that integration of ICT (accounting software packages and IT knowledge and skills into accounting education (curriculum would help accounting graduates fulfill their responsibility of adding value to organizations. Consequently, it was recommended that the Nigeria Universities Commission (NUC and relevant educational bodies should compulsorily integrate (in all higher institution into accounting curriculum at all level a practical course on accounting packages and IT knowledge and skills.

  4. Enhanced light emission from Carbon Nanotubes integrated in silicon micro-resonator

    CERN Document Server

    Noury, Adrien; Vivien, Laurent; Izard, Nicolas

    2015-01-01

    Single-wall carbon nanotube are considered a fascinating nanomaterial for photonic applications and are especially promising for efficient light emitter in the telecommunication wavelength range. Furthermore, their hybrid integration with silicon photonic structures makes them an ideal platform to explore the carbon nanotube instrinsic properties. Here we report on the strong photoluminescence enhancement from carbon nanotubes integrated in silicon ring resonator circuit under two pumping configurations: surface-illuminated pumping at 735 nm and collinear pumping at 1.26 {\\mu}m. Extremely efficient rejection of the non-resonant photoluminescence was obtained. In the collinear approach, an emission efficiency enhancement by a factor of 26 has been demonstrated in comparison with classical pumping scheme. This demonstration pave the way for the development of integrated light source in silicon based on carbon nanotubes.

  5. Integrating experiences from operations into engineering design: modelling knowledge transfer in the offshore oil industry

    DEFF Research Database (Denmark)

    Souza da Conceição, Carolina; Broberg, Ole; Paravizo, Esdras

    2017-01-01

    and workwise distance between operations and engineering design teams, integrating human factors and transferring knowledge are key aspects when designing for better performance systems. Research Objective: Based on an in-depth empirical investigation in an offshore oil company, this study aims to provide......Summative Statement: Integrating human factors and users’ experiences in design projects is a well-known challenge. This study focus on the specific challenges for transferring these experiences and how using a knowledge transfer model can help this integration on the design of high-risk productive...... a framework for the knowledge transfer process from operations into engineering design that helps identifying and facing the challenges for such a transfer process. Methodology: The study was carried out as a case study in an offshore oil company. We used the empirical data collected through interviews...

  6. THE INTEGRATION OF PIGMEAT MARKETS IN THE EU. EVIDENCE FROM A REGULAR MIXED VINE COPULA

    Directory of Open Access Journals (Sweden)

    Vasilis GRIGORIADIS

    2016-04-01

    Full Text Available The objective of this work is to investigate the degree of integration of national pigmeat markets in the EU. This is pursued using monthly wholesale prices from seven major markets and the statistical tool of mixed R-vine copulas. The empirical results suggest that the markets considered do not constitute a great pool in which prices move, boom, and crash together. The markets of Belgium, Germany, and the Netherlands exhibit a higher degree of integration relative to the others, whereas the Italian market exhibits a lower degree of integration. Also, there is an indication that, in certain cases, the benefits of free trade may be unequally distributed between the trading partners.

  7. Shuttle Program Loads Integration: Going From Concept to Operations and Staying Successful

    Science.gov (United States)

    Bernstein, Karen; James, George; Mackey, alden; Murphy, Neil C.; Brolliar, Steve

    2011-01-01

    From the beginning of the Shuttle Program to its end, integrated loads and dynamics analyses and tests have been critical in shaping the vehicle design and operational decisions for NASA and its customers. Starting with scaled models and simple mathematical simulations of the structural dynamics, engineers defined the required structural stiffness and predicted the limit loads for each element of the system. Early structural tests provided reasonable confidence that the models and predictions were good. The first launch of the Space Shuttle brought surprises, though, when the ignition overpressure event caused a forward fuel tank support strut to buckle, among several unexpected effects. The launch pad and other ground equipment became an integral part of the system integration, especially where the acoustic and pressure environments of ignition and lift-off were concerned. Following the Challenger accident, operating limits were changed in response to new understandings of how the integrated system performed. Controlling loads while maximizing performance was a key tenet of the Performance Enhancement design process, which enabled construction of the International Space Station. During the return to flight after the Columbia accident, engineers grew to understand that loads during the roll maneuver were also important to the vehicle s structural margin and life. At this point the crawler transport from the Vehicle Assembly Building to the launch pad also became a part of the integrated loads analysis. Even in the last years of the Space Shuttle Program, new data still provided interesting insights into this complicated and fascinating spaceship. This paper will present some examples of the important findings by the team of specialists that supported the Integrated Loads and Dynamics Panel for the Space Shuttle Program.

  8. Enhanced Device and Circuit-Level Performance Benchmarking of Graphene Nanoribbon Field-Effect Transistor against a Nano-MOSFET with Interconnects

    OpenAIRE

    Huei Chaeng Chin; Cheng Siong Lim; Weng Soon Wong; Danapalasingam, Kumeresan A.; Arora, Vijay K.; Michael Loong Peng Tan

    2014-01-01

    Comparative benchmarking of a graphene nanoribbon field-effect transistor (GNRFET) and a nanoscale metal-oxide-semiconductor field-effect transistor (nano-MOSFET) for applications in ultralarge-scale integration (ULSI) is reported. GNRFET is found to be distinctly superior in the circuit-level architecture. The remarkable transport properties of GNR propel it into an alternative technology to circumvent the limitations imposed by the silicon-based electronics. Budding GNRFET, using the circui...

  9. Moving integrated weed management from low level to a truly integrated and highly specific weed management system using advanced technologies

    NARCIS (Netherlands)

    Young, S.L.; Pitla, S.K.; Evert, Van F.K.; Schueller, J.K.; Pierce, F.J.; Liebman, Matt

    2017-01-01

    Integrated weed management (IWM) is one of the most commonly referred to approaches for sustainable and effective weed control in agriculture, yet it is not widely practiced, likely because current IWM systems fail to meet performance expectations of growers. The effectiveness and value of IWM syste

  10. On the integration of financial markets: How strong is the evidence from five international stock markets?

    Science.gov (United States)

    Bentes, Sónia R.

    2015-07-01

    This paper examines the integration of financial markets using data from five international stock markets in the context of globalization. The theoretical basis of this study relies on the price theory and the Law of One Price, which was adjusted to the framework of financial markets. When price levels are nonstationary, cointegration and the error correction model constitute a powerful tool for the empirical examination of market integration. The error correction model provides a fully dynamic framework that allows to separating the long and the short run effects of the integration process. A dataset encompassing the daily stock price series of the PSI 20 (Portugal), IBEX 35 (Spain), FTSE 100 (UK), NIKKEI 225 (Japan) and SP 500 (US) indices from January 4th 1999 to September 19th 2014 is employed. The results highlight that these five stock markets are linked together by just one long-run relationship, although short-run movements are also present, which causes distinct deviations from the long-run equilibrium relationship. Endogeneity prevails in the system as a whole. While market integration in the sense of the Law of One Price holds, pairwise full price transmission has limited evidence. The results therefore show that stock market price movements are highly nonlinear and complex.

  11. From a Generic Framework for Expressing Integrity Properties to a Dynamic mac Enforcement for Operating Systems

    Science.gov (United States)

    Clemente, Patrice; Rouzaud-Cornabas, Jonathan; Toinard, Christian

    Protection deals with the enforcement of integrity and confidentiality. Integrity violations often lead to confidentiality vulnerabilities. This paper proposes a novel approach of Mandatory Access Control enforcement for guaranteeing a large range of integrity properties. In the literature, many integrity models are proposed such as the Biba model, data integrity, subject integrity, domain integrity and Trusted Path Execution. There can be numerous integrity models. In practice, an administrator needs to combine various integrity models. The major limitations of existing solutions deal first with the support of indirect activities aiming at violating integrity and second with the impossibility to extend existing models or even define new ones.

  12. Learning from graphically integrated 2D and 3D representations improves retention of neuroanatomy

    Science.gov (United States)

    Naaz, Farah

    Visualizations in the form of computer-based learning environments are highly encouraged in science education, especially for teaching spatial material. Some spatial material, such as sectional neuroanatomy, is very challenging to learn. It involves learning the two dimensional (2D) representations that are sampled from the three dimensional (3D) object. In this study, a computer-based learning environment was used to explore the hypothesis that learning sectional neuroanatomy from a graphically integrated 2D and 3D representation will lead to better learning outcomes than learning from a sequential presentation. The integrated representation explicitly demonstrates the 2D-3D transformation and should lead to effective learning. This study was conducted using a computer graphical model of the human brain. There were two learning groups: Whole then Sections, and Integrated 2D3D. Both groups learned whole anatomy (3D neuroanatomy) before learning sectional anatomy (2D neuroanatomy). The Whole then Sections group then learned sectional anatomy using 2D representations only. The Integrated 2D3D group learned sectional anatomy from a graphically integrated 3D and 2D model. A set of tests for generalization of knowledge to interpreting biomedical images was conducted immediately after learning was completed. The order of presentation of the tests of generalization of knowledge was counterbalanced across participants to explore a secondary hypothesis of the study: preparation for future learning. If the computer-based instruction programs used in this study are effective tools for teaching anatomy, the participants should continue learning neuroanatomy with exposure to new representations. A test of long-term retention of sectional anatomy was conducted 4-8 weeks after learning was completed. The Integrated 2D3D group was better than the Whole then Sections group in retaining knowledge of difficult instances of sectional anatomy after the retention interval. The benefit

  13. From "glycosyltransferase" to "congenital muscular dystrophy": integrating knowledge from NCBI Entrez Gene and the Gene Ontology.

    Science.gov (United States)

    Sahoo, Satya S; Zeng, Kelly; Bodenreider, Olivier; Sheth, Amit

    2007-01-01

    Entrez Gene (EG), Online Mendelian Inheritance in Man (OMIM) and the Gene Ontology (GO) are three complementary knowledge resources that can be used to correlate genomic data with disease information. However, bridging between genotype and phenotype through these resources currently requires manual effort or the development of customized software. In this paper, we argue that integrating EG and GO provides a robust and flexible solution to this problem. We demonstrate how the Resource Description Framework (RDF) developed for the Semantic Web can be used to represent and integrate these resources and enable seamless access to them as a unified resource. We illustrate the effectiveness of our approach by answering a real-world biomedical query linking a specific molecular function, glycosyltransferase, to the disorder congenital muscular dystrophy.

  14. Scattering from the Potential Barrier $V=cosh^{-2} \\omega x$ from the Path Integration over SO(1,2)

    CERN Document Server

    Ahmedov, H

    1996-01-01

    Unitary irreducible representation of the group SO(1,2) is obtained in the mixed basis, i.e. between the compact and noncompact basis and the new addition theorems are derived which are required in path integral applications involving the positively signed potential. The Green function for the potential barrier $V=cosh^{-2}\\omega x$ is evaluated from the path integration over the coset space SO(1,2)/K where K is the compact subgroup.The transition and the reflection coefficients are given.Results for the moving barrier $V=cosh^{-2}\\omega (x-g_0t)$ are also presented.

  15. Preservice Teachers' Capacity to Teach Self-Regulated Learning: Integrating Learning from Problems and Learning from Successes

    Science.gov (United States)

    Michalsky, Tova; Schechter, Chen

    2013-01-01

    Using a quasi-experimental design, we integrated systematic learning from problematic and successful experiences into teachers' preparatory programs and examined how such learning affected preservice physics teachers' capacity to teach students self-regulated learning (SRL). Results indicated that preservice teachers who contemplated both…

  16. Measurements of Integration Gain for the Cospas-Sarsat System from Geosynchronous Satellites

    Science.gov (United States)

    Klein-Lebbink, Elizabeth; Christo, James; Peters, Robert; Nguyen, Xuan

    2015-01-01

    The GOES-R satellite is the first satellite to use a standard straight bent pipe transponder with no on-board re-modulation to support Search and Rescue (SAR) operations. Here, we report on the link measurements with a high fidelity satellite transponder simulator made up of satellite EDU (Engineering Design Units) components using an uplink from a beacon simulator and received by a GEOLUT (GEOsynchronous satellite Local User Terminal). We also report on the first ever measurements showing the performance gain obtained by the signal integration performed by the GEOLUT. In addition, a simulator made of commercially available off-the-shelf components assembled to develop the test plan was found to perform very close to the high fidelity simulator. In this paper, we describe what message integration is, how it is implemented in the particular satellite receiving station model used for this tests, and show the measured improvement in message decoding due to this integration process. These are the first tests to quantify the integration gain and are the first tests on the new SARSAT standard for the bent pipe (no onboard re-modulation) repeater used in GOES-R. An inexpensive satellite simulator to run test scripts built from off the shelf components was also found to have the same performance as a high fidelity simulator using actual satellite EDUs.

  17. Land cover data from Landsat single-date archive imagery: an integrated classification approach

    Science.gov (United States)

    Bajocco, Sofia; Ceccarelli, Tomaso; Rinaldo, Simone; De Angelis, Antonella; Salvati, Luca; Perini, Luigi

    2012-10-01

    The analysis of land cover dynamics provides insight into many environmental problems. However, there are few data sources which can be used to derive consistent time series, remote sensing being one of the most valuable ones. Due to their multi-temporal and spatial coverage needs, such analysis is usually based on large land cover datasets, which requires automated, objective and repeatable procedures. The USGS Landsat archives provide free access to multispectral, high-resolution remotely sensed data starting from the mid-eighties; in many cases, however, only single date images are available. This paper suggests an objective approach for generating land cover information from 30m resolution and single date Landsat archive satellite imagery. A procedure was developed integrating pixel-based and object-oriented classifiers, which consists of the following basic steps: i) pre-processing of the satellite image, including radiance and reflectance calibration, texture analysis and derivation of vegetation indices, ii) segmentation of the pre-processed image, iii) its classification integrating both radiometric and textural properties. The integrated procedure was tested for an area in Sardinia Region, Italy, and compared with a purely pixel-based one. Results demonstrated that a better overall accuracy, evaluated against the available land cover cartography, was obtained with the integrated (86%) compared to the pixel-based classification (68%) at the first CORINE Land Cover level. The proposed methodology needs to be further tested for evaluating its trasferability in time (constructing comparable land cover time series) and space (for covering larger areas).

  18. From Foucault to Freire Through Facebook: Toward an Integrated Theory of mHealth.

    Science.gov (United States)

    Bull, Sheana; Ezeanochie, Nnamdi

    2016-08-01

    To document the integration of social science theory in literature on mHealth (mobile health) and consider opportunities for integration of classic theory, health communication theory, and social networking to generate a relevant theory for mHealth program design. A secondary review of research syntheses and meta-analyses published between 2005 and 2014 related to mHealth, using the AMSTAR (A Measurement Tool to Assess Systematic Reviews) methodology for assessment of the quality of each review. High-quality articles from those reviews using a randomized controlled design and integrating social science theory in program design, implementation, or evaluation were reviewed. Results There were 1,749 articles among the 170 reviews with a high AMSTAR score (≥30). Only 13 were published from 2005 to 2014, used a randomized controlled design and made explicit mention of theory in any aspect of their mHealth program. All 13 included theoretical perspectives focused on psychological and/or psychosocial theories and constructs. Conclusions There is a very limited use of social science theory in mHealth despite demonstrated benefits in doing so. We propose an integrated theory of mHealth that incorporates classic theory, health communication theory, and social networking to guide development and evaluation of mHealth programs. © 2015 Society for Public Health Education.

  19. Scientific publications from Arab world in leading journals of Integrative and Complementary Medicine: a bibliometric analysis

    OpenAIRE

    Zyoud, Sa’ed H.; Al-Jabi, Samah W; Sweileh, Waleed M.

    2015-01-01

    Background Bibliometric analysis is increasingly employed as a useful tool to assess the quantity and quality of research performance. The specific goal of the current study was to evaluate the performance of research output originating from Arab world and published in international Integrative and Complementary Medicine (ICM) journals. Methods Original scientific publications and reviews from the 22 Arab countries that were published in 22 international peer-reviewed ICM journals during all ...

  20. Responses to mineral nutrient availability and heterogeneity in physiologically integrated sedges from contrasting habitats.

    Science.gov (United States)

    D'Hertefeldt, T; Falkengren-Grerup, U; Jónsdóttir, I S

    2011-05-01

    Clonal plants from poor habitats benefit less from morphologically plastic responses to heterogeneity than plants from more productive sites. In addition, physiological integration has been suggested to either increase or decrease the foraging efficiency of clonal plants. We tested the capacity for biomass production and morphological response in two closely related, rhizomatous species from habitats that differ in resource availability, Carex arenaria (from poor sand dunes) and C. disticha (from nutrient-richer, moister habitats). We expected lower total biomass production and reduced morphological plasticity in C. arenaria, and that both species would produce more ramets in high nutrient patches, either in response to signals transported through physiological integration, or by locally determined responses to nutrient availability. To investigate mineral nutrient heterogeneity, plants were grown in boxes divided into two compartments with homogeneous or heterogeneous supply of high (H) or low (L) nutrient levels, resulting in four treatments, H-H, H-L, L-H and L-L. Both C. arenaria and C. disticha produced similar biomass in high nutrient treatments. C. disticha responded to high nutrients by increased biomass production and branching of the young parts and by altering root:shoot ratio and rhizome lengths, while C. arenaria showed localised responses to high nutrients in terms of local biomass and branch production in high nutrient patches. The results demonstrated that although it has a conservative morphology, C. arenaria responded to nutrient heterogeneity through morphological plasticity. An analysis of costs and benefits of integration on biomass production showed that young ramets of both species benefited significantly from physiological integration, but no corresponding costs were found. This suggests that plants from resource-poor but dynamic habitats like sand dunes respond morphologically to high nutrient patches. The two species responded to nutrient

  1. Reflections on the Past and Future of Integrative Medicine from a Lifelong Student of the Integration of Chinese and Western Medicine

    Institute of Scientific and Technical Information of China (English)

    David Eisenberg, M.D.

    2011-01-01

    This issue of the Chinese Joumal of Integrative Medicine includes a discussion of integrative medicine (IM)from various perspectives.Dr.Andrew Weil provides a comprehensive overview of the field from the US and Western perspectives(1);doctors Dobos and Tao(2) delineate those aspects of Westem IM which relate directly to Traditional Chinese Medicine (TCM);doctors Lee,Shin,et al(3) provide a systematic review of controlled trials of IM from the Korean literature;and Dr.Robinson contrasts IM in the West (United Kingdom) with IM in China(4).Importantly,each of these articles highlights the extraordinary relevance of TCM to emerging models of "IM" worldwide.

  2. INDIGO - INtegrated data warehouse of microbial genomes with examples from the red sea extremophiles.

    Science.gov (United States)

    Alam, Intikhab; Antunes, André; Kamau, Allan Anthony; Ba Alawi, Wail; Kalkatawi, Manal; Stingl, Ulrich; Bajic, Vladimir B

    2013-01-01

    The next generation sequencing technologies substantially increased the throughput of microbial genome sequencing. To functionally annotate newly sequenced microbial genomes, a variety of experimental and computational methods are used. Integration of information from different sources is a powerful approach to enhance such annotation. Functional analysis of microbial genomes, necessary for downstream experiments, crucially depends on this annotation but it is hampered by the current lack of suitable information integration and exploration systems for microbial genomes. We developed a data warehouse system (INDIGO) that enables the integration of annotations for exploration and analysis of newly sequenced microbial genomes. INDIGO offers an opportunity to construct complex queries and combine annotations from multiple sources starting from genomic sequence to protein domain, gene ontology and pathway levels. This data warehouse is aimed at being populated with information from genomes of pure cultures and uncultured single cells of Red Sea bacteria and Archaea. Currently, INDIGO contains information from Salinisphaera shabanensis, Haloplasma contractile, and Halorhabdus tiamatea - extremophiles isolated from deep-sea anoxic brine lakes of the Red Sea. We provide examples of utilizing the system to gain new insights into specific aspects on the unique lifestyle and adaptations of these organisms to extreme environments. We developed a data warehouse system, INDIGO, which enables comprehensive integration of information from various resources to be used for annotation, exploration and analysis of microbial genomes. It will be regularly updated and extended with new genomes. It is aimed to serve as a resource dedicated to the Red Sea microbes. In addition, through INDIGO, we provide our Automatic Annotation of Microbial Genomes (AAMG) pipeline. The INDIGO web server is freely available at http://www.cbrc.kaust.edu.sa/indigo.

  3. INDIGO - INtegrated data warehouse of microbial genomes with examples from the red sea extremophiles.

    Directory of Open Access Journals (Sweden)

    Intikhab Alam

    Full Text Available BACKGROUND: The next generation sequencing technologies substantially increased the throughput of microbial genome sequencing. To functionally annotate newly sequenced microbial genomes, a variety of experimental and computational methods are used. Integration of information from different sources is a powerful approach to enhance such annotation. Functional analysis of microbial genomes, necessary for downstream experiments, crucially depends on this annotation but it is hampered by the current lack of suitable information integration and exploration systems for microbial genomes. RESULTS: We developed a data warehouse system (INDIGO that enables the integration of annotations for exploration and analysis of newly sequenced microbial genomes. INDIGO offers an opportunity to construct complex queries and combine annotations from multiple sources starting from genomic sequence to protein domain, gene ontology and pathway levels. This data warehouse is aimed at being populated with information from genomes of pure cultures and uncultured single cells of Red Sea bacteria and Archaea. Currently, INDIGO contains information from Salinisphaera shabanensis, Haloplasma contractile, and Halorhabdus tiamatea - extremophiles isolated from deep-sea anoxic brine lakes of the Red Sea. We provide examples of utilizing the system to gain new insights into specific aspects on the unique lifestyle and adaptations of these organisms to extreme environments. CONCLUSIONS: We developed a data warehouse system, INDIGO, which enables comprehensive integration of information from various resources to be used for annotation, exploration and analysis of microbial genomes. It will be regularly updated and extended with new genomes. It is aimed to serve as a resource dedicated to the Red Sea microbes. In addition, through INDIGO, we provide our Automatic Annotation of Microbial Genomes (AAMG pipeline. The INDIGO web server is freely available at http://www.cbrc.kaust.edu.sa/indigo.

  4. Integration of Capital Markets from Central and Eastern Europe: Implications for EU Investors

    Directory of Open Access Journals (Sweden)

    Alexandra HOROBET

    2014-04-01

    Full Text Available Our paper investigates the extent of capital market co-movements between three emerging markets Czech Republic, Hungary and Poland and three developed markets from the European Union – Austria, France and Germany. We test whether an increase in correlations between the six markets took place in recent years, as revealing higher integration of capital markets in the region. We find a statistically significant positive trend in cross-market correlations between 1999 and 2008, before the emergence of the global financial crisis. Movements in national stock markets are not fully synchronized, but increases in market volatilities lead to increases in cross-country correlations. There is a long-term relationship between some of these countries capital markets, and information is transmitted from one market to the other. Our findings confirm previous studies and lead to the conclusion that stock markets from Central and Eastern Europe became more integrated with the developed markets in European Union.

  5. Multimedia integration of cartographic source materials for researching and presenting phenomena from economic history

    Science.gov (United States)

    Lorek, Dariusz

    2016-12-01

    The article presents a framework for integrating historical sources with elements of the geographical space recorded in unique cartographic materials. The aim of the project was to elaborate a method of integrating spatial data sources that would facilitate studying and presenting the phenomena of economic history. The proposed methodology for multimedia integration of old materials made it possible to demonstrate the successive stages of the transformation which was characteristic of the 19th-century space. The point of reference for this process of integrating information was topographic maps from the first half of the 19th century, while the research area comprised the castle complex in Kórnik together with the small town - the pre-industrial landscape in Wielkopolska (Greater Poland). On the basis of map and plan transformation, graphic processing of the scans of old drawings, texture mapping of the facades of historic buildings, and a 360° panorama, the source material collected was integrated. The final product was a few-minute-long video, composed of nine sequences. It captures the changing form of the castle building together with its facades, the castle park, and its further topographic and urban surroundings, since the beginning of the 19th century till the present day. For a topographic map sheet dating back to the first half of the 19th century, in which the hachuring method had been used to present land relief, a terrain model was generated. The transition from parallel to bird's-eye-view perspective served to demonstrate the distinctive character of the pre-industrial landscape.

  6. Pentoxifylline increase sperm motility in devitrified spermatozoa from asthenozoospermic patient without damage chromatin and DNA integrity.

    Science.gov (United States)

    Nabi, Ali; Khalili, Mohammad Ali; Fesahat, Farzaneh; Talebi, Alireza; Ghasemi-Esmailabad, Saeed

    2017-06-01

    The freeze-thaw process results in reduced motility, viability and fertilization potential of human spermatozoa. So, a variety of substances were evaluated in order to enhance human sperm resistance to the stress of cryopreservation, such as Pentoxifylline (PTX) for improving the Intracytoplasmic sperm injection (ICSI) outcomes. The aim was to investigate the effect of PTX on sperm parameters and chromatin/DNA integrity of asthenozoospermic semen post vitrification. A total of 30 semen specimens were obtained from infertile men with asthenozoospermia. The cryoprotectant-free vitrification was performed for the samples after assessment of sperm parameters. After warming, each sample was exposed for 30 min to 3.6 mmol/l PTX in experimental group and the control group without any treatment apposing at 37 °C for 30 min in regard, to repeat all in vitro analysis (sperm parameters and DNA integrity assay). Regardless of the vitrification devastating impacts on sperm parameters, incubation of post vitrified samples with PTX increased the rate of progressive motility (P integrity of asthenozoospermic sperm samples. The data showed that PTX was able to improve sperm movement without any adverse effects on sperm chromatin/DNA integrity in vitrification program. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Detecting transforming growth factor-β release from liver cells using an aptasensor integrated with microfluidics.

    Science.gov (United States)

    Matharu, Zimple; Patel, Dipali; Gao, Yandong; Haque, Amranul; Zhou, Qing; Revzin, Alexander

    2014-09-02

    We developed a cell-culture/biosensor platform consisting of aptamer-modified Au electrodes integrated with reconfigurable microfluidics for monitoring of transforming growth factor-beta 1 (TGF-β1), an important inflammatory and pro-fibrotic cytokine. Aptamers were thiolated, labeled with redox reporters, and self-assembled on gold surfaces. The biosensor was determined to be specific for TGF-β1 with an experimental detection limit of 1 ng/mL and linear range extending to 250 ng/mL. Upon determining figures of merit, aptasensor was miniaturized and integrated with human hepatic stellate cells inside microfluidic devices. Reconfigurable microfluidics were developed to ensure that seeding of "sticky" stromal cells did not foul the electrode and compromise sensor performance. This microsystem with integrated aptasensors was used to monitor TGF-β1 release from activated stellate cells over the course of 20 h. The electrochemical response went down upon infusing anti-TGF-β1 antibodies into the microfluidic devices containing activated stellate cells. To further validate aptasensor responses, stellate cells were stained for markers of activation (e.g., alpha smooth muscle actin) and were also tested for presence of TGF-β1 using enzyme linked immunosorbent assay (ELISA). Given the importance of TGF-β1 as a fibrogenic signal, a microsystem with integrated biosensors for local and continuous detection of TGF-β1 may prove to be an important tool to study fibrosis of the liver and other organs.

  8. Situation of Integrative Medicine in China:Results from a National Survey in 2004

    Institute of Scientific and Technical Information of China (English)

    CHEN Ke-ji; LU Ai-ping

    2006-01-01

    Integrative medicine (IM) usually called integrated traditional and Western medicine in China, which came into being in the 1950s as a new form of medicine, although is now developing quickly, little is known about its status and existing problems. So a national survey in China was conducted through questionnaire in 2004 by Chinese Association of Integrative Medicine with the support of State Administration of Traditional Chinese Medicine (SATCM). The results show that, of all the medical professionals investigated in this survey, 91.21% and 93.52% respondents respectively favored IM as the best diagnostic and therapeutic method. Of all the patients who once went through TCM, Western medicine (WM) and IM therapies,68.85%, 65.45% and 71.2% respondents respectively most appreciated IM, IM hospitals and IM therapeutic treatments. Most of the 6 595 respondents held that the optimal scientific research strategy in TCM should be integrating modern medical research method (n = 2 380) or modern scientific method (n = 2 920). However, many hospitals exposed the problems in the aspects of governmental supports and funding supports, human resources, and domestic or international academic activities. These results indicated that IM is the patients' social needs and doctors' aspiration in China. For further development of IM, the enhancement of scientific research construction and assistance by policies and finance from the government and other institutions are urgently needed in China.

  9. MSblender: A probabilistic approach for integrating peptide identifications from multiple database search engines.

    Science.gov (United States)

    Kwon, Taejoon; Choi, Hyungwon; Vogel, Christine; Nesvizhskii, Alexey I; Marcotte, Edward M

    2011-07-01

    Shotgun proteomics using mass spectrometry is a powerful method for protein identification but suffers limited sensitivity in complex samples. Integrating peptide identifications from multiple database search engines is a promising strategy to increase the number of peptide identifications and reduce the volume of unassigned tandem mass spectra. Existing methods pool statistical significance scores such as p-values or posterior probabilities of peptide-spectrum matches (PSMs) from multiple search engines after high scoring peptides have been assigned to spectra, but these methods lack reliable control of identification error rates as data are integrated from different search engines. We developed a statistically coherent method for integrative analysis, termed MSblender. MSblender converts raw search scores from search engines into a probability score for every possible PSM and properly accounts for the correlation between search scores. The method reliably estimates false discovery rates and identifies more PSMs than any single search engine at the same false discovery rate. Increased identifications increment spectral counts for most proteins and allow quantification of proteins that would not have been quantified by individual search engines. We also demonstrate that enhanced quantification contributes to improve sensitivity in differential expression analyses.

  10. From polarisation to practice: puzzles and insights on integrated approaches from public health professionals.

    Science.gov (United States)

    Buffardi, Anne L

    2014-01-01

    Much of the debate in the global health literature about vertical and horizontal programmatic approaches, between narrowly targeted interventions and those providing broader system-wide support, has taken place at the global level. Based on a comparative case study of international donors in the health sector in Peru that varied in their vertical-horizontal orientation, this article examines the extent to which health care practitioners and national policy-makers perceive and attempt to reconcile the tension between these approaches. Informants readily identified advantages and disadvantages of both approaches, but did not perceive a marked vertical-horizontal division, suggesting that tensions appear to be less pronounced in practice than academic debates suggest. A clear consensus did not emerge, and although more people spoke of a mixed approached, they too puzzled over how best to balance trade-offs. In practice, there were examples of more integrated approaches, targeted aspects of horizontal programmes and system-strengthening elements of vertical programmes; however, they were not explicitly identified as such. Practitioner perspectives reinforced the diverse and dynamic nature of disease, both epidemics and country profiles, and suggest that focusing on periods of transition and points of integration may be a fruitful path forward.

  11. INTEGRAL/SPI Observations of Electron-Positron Annihilation Radiation from our Galaxy

    Science.gov (United States)

    Teegarden, B. J.; Watanabe, K.; Knoedlseder, J.; Jean, P.; Lonjou, V.; Weidenspointner, G.; Skinner, G.; von Ballmoos, P.; Vedrenne, G.; Roques, J.-P.; Schanne, S.; Schoenfelder, V.

    2004-12-01

    The spectrometer on INTEGRAL (SPI) is a coded-aperture gamma-ray telescope with moderate angular resolution (3 deg) and superior energy resolution (2 keV at 511 keV). One of it's principal science goals is the detailed study of 511 keV electron-positron annihilation from our Galaxy. The origin of this radiation remains a mystery, however current morphological studies suggest an older stellar population. There has also been recent speculation on the possibility of the existence of light (< 100 MeV) dark matter particles whose annihilation or decay could produce the observed 511 keV emission. In this paper we summarize the current results from SPI, compare them with previous results and discuss their implication on possible models for the production of the annihilation radiation. INTEGRAL is a project of ESA. This work was supported by NASA and CNES.

  12. Safeguard By Design Lessons Learned from DOE Experience Integrating Safety into Design

    Energy Technology Data Exchange (ETDEWEB)

    Hockert, John; Burbank, Roberta L.

    2010-04-13

    This paper identifies the lessons to be learned for the institutionalization of Safeguards by Design (SBD) from the Department of Energy (DOE) experience developing and implementing DOE-STD-1189-2008, Integration of Safety into the Design Process. The experience is valuable because of the similarity of the challenges of integrating safety and safeguards into the design process. The paper reviews the content and development of DOE-STD-1189-2008 from its initial concept in January 2006 to its issuance in March 2008. Lessons learned are identified in the areas of the development and structure of requirements for the SBD process; the target audience for SBD requirements and guidance, the need for a graded approach to SBD, and a possible strategy for development and implementation of SBD within DOE.

  13. An Integrated, Low Temperature Process to Capture and Sequester Carbon Dioxide from Industrial Emissions

    Science.gov (United States)

    Wendlandt, R. F.; Foremski, J. J.

    2013-12-01

    Laboratory experiments show that it is possible to integrate (1) the chemistry of serpentine dissolution, (2) capture of CO2 gas from the combustion of natural gas and coal-fired power plants using aqueous amine-based solvents, (3) long-term CO2 sequestration via solid phase carbonate precipitation, and (4) capture solvent regeneration with acid recycling in a single, continuous process. In our process, magnesium is released from serpentine at 300°C via heat treatment with ammonium sulfate salts or at temperatures as low as 50°C via reaction with sulfuric acid. We have also demonstrated that various solid carbonate phases can be precipitated directly from aqueous amine-based (NH3, MEA, DMEA) CO2 capture solvent solutions at room temperature. Direct precipitation from the capture solvent enables regenerating CO2 capture solvent without the need for heat and without the need to compress the CO2 off gas. We propose that known low-temperature electrochemical methods can be integrated with this process to regenerate the aqueous amine capture solvent and recycle acid for dissolution of magnesium-bearing mineral feedstocks and magnesium release. Although the direct precipitation of magnesite at ambient conditions remains elusive, experimental results demonstrate that at temperatures ranging from 20°C to 60°C, either nesquehonite Mg(HCO3)(OH)●2H2O or a double salt with the formula [NH4]2Mg(CO3)2●4H2O or an amorphous magnesium carbonate precipitate directly from the capture solvent. These phases are less desirable for CO2 sequestration than magnesite because they potentially remove constituents (water, ammonia) from the reaction system, reducing the overall efficiency of the sequestration process. Accordingly, the integrated process can be accomplished with minimal energy consumption and loss of CO2 capture and acid solvents, and a net generation of 1 to 4 moles of H2O/6 moles of CO2 sequestered (depending on the solid carbonate precipitate and amount of produced H2

  14. Integrating the results of user research into medical device development: insights from a case study

    Directory of Open Access Journals (Sweden)

    Martin Jennifer L

    2012-07-01

    Full Text Available Abstract Background It is well established that considering users is an important aspect of medical device development. However it is also well established that there are numerous barriers to successfully conducting user research and integrating the results into product development. It is not sufficient to simply conduct user research, it must also be effectively integrated into product development. Methods A case study of the development of a new medical imaging device was conducted to examine in detail how users were involved in a medical device development project. Two user research studies were conducted: a requirements elicitation interview study and an early prototype evaluation using contextual inquiry. A descriptive in situ approach was taken to investigate how these studies contributed to the product development process and how the results of this work influenced the development of the technology. Data was collected qualitatively through interviews with the development team, participant observation at development meetings and document analysis. The focus was on investigating the barriers that exist to prevent user data from being integrated into product development. Results A number of individual, organisational and system barriers were identified that functioned to prevent the results of the user research being fully integrated into development. The user and technological aspects of development were seen as separate work streams during development. The expectations of the developers were that user research would collect requirements for the appearance of the device, rather than challenge its fundamental concept. The manner that the user data was communicated to the development team was not effective in conveying the significance or breadth of the findings. Conclusion There are a range of informal and formal organisational processes that can affect the uptake of user data during medical device development. Adopting formal decision

  15. Integrating the results of user research into medical device development: insights from a case study.

    Science.gov (United States)

    Martin, Jennifer L; Barnett, Julie

    2012-07-19

    It is well established that considering users is an important aspect of medical device development. However it is also well established that there are numerous barriers to successfully conducting user research and integrating the results into product development. It is not sufficient to simply conduct user research, it must also be effectively integrated into product development. A case study of the development of a new medical imaging device was conducted to examine in detail how users were involved in a medical device development project. Two user research studies were conducted: a requirements elicitation interview study and an early prototype evaluation using contextual inquiry. A descriptive in situ approach was taken to investigate how these studies contributed to the product development process and how the results of this work influenced the development of the technology. Data was collected qualitatively through interviews with the development team, participant observation at development meetings and document analysis. The focus was on investigating the barriers that exist to prevent user data from being integrated into product development. A number of individual, organisational and system barriers were identified that functioned to prevent the results of the user research being fully integrated into development. The user and technological aspects of development were seen as separate work streams during development. The expectations of the developers were that user research would collect requirements for the appearance of the device, rather than challenge its fundamental concept. The manner that the user data was communicated to the development team was not effective in conveying the significance or breadth of the findings. There are a range of informal and formal organisational processes that can affect the uptake of user data during medical device development. Adopting formal decision making processes may assist manufacturers to take a more integrated and

  16. Rural bioenergy: innovative integrated biosystem design for fuel and food from agrowastes

    Energy Technology Data Exchange (ETDEWEB)

    Selvam, Pagandai V. Pannir; Santiago, Brunno Henrique de S. [Universidade Federal de Alagoas (UFAL), Maceio, AL (Brazil)], email: pannirbr@gmail.com; Almeida, Louizy Minora C.A. de; Israel, Samy B.S. [Universidade Federal do Rio Grande do Norte (DEQ/CT/UFRN), Natal, RN (Brazil). Centro de Tecnologia. Dept. de Engenharia Quimica

    2008-07-01

    Brazil is the leader known for its ethanol biofuel development, but also for biomass charcoal, yet lacks in clean rural biofuel production. This paper deals with the system design for sustainable rural projects developments based on the the bioenergy production from biomass wastes using Innovative process equipment design and the process optimization. With the economic objective towards sustainable clean small scale rural energy production, and also the co-production of hot, cold thermal energy, at first, several preliminary projects had been developed and analysed. Then, a detailed project engineering and the results on economical viability were obtained. The dynamic material, energy and cash flow models of the complex integrated food processing and small scale energy productions, were at first constructed using excel electronic spread sheet for Windows. Computer aided system for process modeling and simulation using SUPERPRO, Intelligent Inc. Economic feasibilities studies using genetics algorithms are under developments. The preliminary analysis of cost and investments of the the integrated biomass utilisation projects which are included for this study are: biological aerobic treatment process, methane gas production using anaerobic digestion process, aerobic composting, drying of tropical fruits, effluent treatments, biogas and syngas production as well as cogeneration of energy production for drying and cooling using biogas. These models allowed us the identification of tech economical and scale up problems. The results obtained with several preliminary project development with few case studies are reported for integrated project developments for fuel and food using process and cost simulation models. Several economic problems related with implementation of the small scale rural energy system for sustained local developments based on tropical fruit producing rural areas are analysed and a concept of the integrated bio system for micro enterprise has been

  17. Segregation versus Integration: The Racial Policy of the Marine Corps from 1942-1962

    Science.gov (United States)

    2013-04-21

    quickly diminished. “Paralleling the rise of Jim Crow and legalized segregation in much of America was the cutback in the number of Black sailors, who...intended more to appease the Negro press and other ‘interested’ In essence, these officers felt the social transformation of America should occur in the...abolished segregation, it still was far from being fully integrated. Racism was still prevalent and the Marine Corps continued to place restriction on the

  18. An integrated chip for rapid, sensitive, and multiplexed detection of cardiac biomarkers from fingerprick blood.

    Science.gov (United States)

    Zhang, Guo-Jun; Luo, Zhan Hong Henry; Huang, Min Joon; Ang, Jun'an Jason; Kang, Tae Goo; Ji, Hongmiao

    2011-10-15

    Cardiovascular diseases are the major cause of death among adults worldwide. Electrocardiogram (ECG) is a first test when a patient suffering from chest pain sees a doctor, however, it is lack of the required sensitivity. Standard assays to detect cardiac biomarkers, like enzyme-linked immunosorbent assay (ELISA) are sensitive, but suffer from important sample and reagent consumption in large-scale studies. Moreover they are performed in central laboratories of clinics and hospitals and take a long time, which is highly incompatible with the quick decisions needed to save a heart attack patient. Herein, we describe an integrated chip allowing rapid, sensitive, and simultaneous analysis of three cardiac biomarkers in fingerprick blood. The integrated chip is composed of a filtration chip for plasma separation from blood and a silicon nanowire (SiNW) array sensor chip for protein detection. These two chips are fabricated separately and bonded to form a single unit after alignment. The integrated chip is capable of reducing the dead volume of the sample by eliminating the tubing between the two chips. After the plasma is filtrated by the filtration chip, the SiNW sensor, spotted with three different antibodies, enabled us to detect three cardiac biomarkers, troponin T (cTnT), creatine kinase MM (CK-MM) and creatine kinase MB (CK-MB), simultaneously. The integrated chip is able to attain a low detection limit of 1 pg/ml for the three cardiac biomarkers from 2 μl blood in 45 min. Copyright © 2011 Elsevier B.V. All rights reserved.

  19. An Integrated E-government Adoption Model from Both Citizen and Government Perspectives

    OpenAIRE

    Shang Shanshan

    2014-01-01

    The purpose of E-Government is to provide better services for citizens by taking use of Information Communication Technology and the standard to evaluate the success of an E-Government project is its adoption. The study establishes an integrated E-government adoption model from both the citizen and government perspectives after a deep review of the main support theories in related E-government adoption literatures and the main E-government adoption models. The proposed model includes the citi...

  20. Pyrolyzed Photoresist Electrodes for Integration in Microfluidic Chips for Transmitter Detection from Biological Cells

    DEFF Research Database (Denmark)

    Larsen, Simon Tylsgaard; Argyraki, Aikaterini; Amato, Letizia

    2013-01-01

    In this study, we show how pyrolyzed photoresist carbon electrodes can be used for amperometric detection of potassium-induced transmitter release from large groups of neuronal PC 12 cells. This opens the way for the use of carbon film electrodes in microfabricated devices for neurochemical drug ...... by the difference in photoresist viscosity. By adding a soft bake step to the fabrication procedure, the flatness of pyrolyzed AZ 5214 electrodes could be improved which would facilitate their integration in microfluidic chip devices....

  1. Protecting integrated circuits from excessive charge accumulation during plasma cleaning of multichip modules

    Energy Technology Data Exchange (ETDEWEB)

    Rodenbeck, Christopher T; Girardi, Michael

    2015-04-21

    Internal nodes of a constituent integrated circuit (IC) package of a multichip module (MCM) are protected from excessive charge during plasma cleaning of the MCM. The protected nodes are coupled to an internal common node of the IC package by respectively associated discharge paths. The common node is connected to a bond pad of the IC package. During MCM assembly, and before plasma cleaning, this bond pad receives a wire bond to a ground bond pad on the MCM substrate.

  2. First superburst observed by INTEGRAL, from SAX J1747.0-2853

    DEFF Research Database (Denmark)

    Chenevez, Jérôme; Brandt, Søren; Kuulkers, E.;

    2011-01-01

    A re-analysis of the INTEGRAL Galactic Bulge monitoring observation on February 13 (ATel #3172) shows that the flaring behaviour reported from SAX J1747.0-2853 is in fact due to a superburst. The event started on February 13, 2011 at 13:01:40 UTC with a 2 minutes spike, but the JEM-X (3-30 keV) s...

  3. Linear and Nonlinear Plasmonics from Isotropic and Anisotropic Integrated Nanocomposites for Quantum Information Applications

    Science.gov (United States)

    2014-01-09

    nanoparticles (NPs) were added to luminescent porous silicon by drop casting. These NPs interact with this system by modifying its optical properties ...response by Au NPs in sapphire: Nonlinear optical response of Au metallic NPs, synthesized and embedded in sapphire by using ion implantation, as a...Linear and nonlinear plasmonics from isotropic and anisotropic integrated nanocomposites for quantum information applications. Jorge-Alejandro Reyes

  4. An integrating current transformer for fast extraction from the HIRFL-CSR main ring

    Science.gov (United States)

    Wu, Jun-Xia; Zheng, Jian-Hua; Zhao, Tie-Cheng; Mao, Rui-Shi; Yin, Yan; Yuan, You-Jin; Yang, Jian-Cheng

    2010-01-01

    For any experiment that uses the beam of an accelerator, monitoring the beam intensity is always an important concern. It is particularly useful if one can continuously measure the beam current without disturbing the beam. We report here on test experiments for an Integrating Current Transformer (ICT) used to measure fast extraction beams from the HIRFL-CSR main ring (CSRm). The laboratory tests and beam intensity measurement results are presented in this paper. The influence of the kicker noise is also analyzed.

  5. Structural elucidation of sorghum lignins from an integrated biorefinery process based on hydrothermal and alkaline treatments.

    Science.gov (United States)

    Sun, Shao-Long; Wen, Jia-Long; Ma, Ming-Guo; Sun, Run-Cang

    2014-08-13

    An integrated process based on hydrothermal pretreatment (HTP) (i.e., 110-230 °C, 0.5-2.0 h) and alkaline post-treatment (2% NaOH at 90 °C for 2.0 h) has been performed for the production of xylooligosaccharide, lignin, and digestible substrate from sweet sorghum stems. The yield, purity, dissociation mechanisms, structural features, and structural transformations of alkali lignins obtained from the integrated process were investigated. It was found that the HTP process facilitated the subsequent alkaline delignification, releasing lignin with the highest yield (79.3%) and purity from the HTP residue obtained at 190 °C for 0.5 h. All of the results indicated that the cleavage of the β-O-4 linkages and degradation of β-β and β-5 linkages occurred under the harsh HTP conditions. Depolymerization and condensation reactions simultaneously occurred at higher temperatures (≥ 170 °C). Moreover, the thermostability of lignin was positively related to its molecular weight, but was also affected by the inherent structures, such as β-O-4 linkages and condensed units. These findings will enhance the understanding of structural transformations of the lignins during the integrated process and maximize the potential utilizations of the lignins in a current biorefinery process.

  6. Integrative Modeling of Macromolecular Assemblies from Low to Near-Atomic Resolution

    Directory of Open Access Journals (Sweden)

    Xiaojun Xu

    2015-01-01

    Full Text Available While conventional high-resolution techniques in structural biology are challenged by the size and flexibility of many biological assemblies, recent advances in low-resolution techniques such as cryo-electron microscopy (cryo-EM and small angle X-ray scattering (SAXS have opened up new avenues to define the structures of such assemblies. By systematically combining various sources of structural, biochemical and biophysical information, integrative modeling approaches aim to provide a unified structural description of such assemblies, starting from high-resolution structures of the individual components and integrating all available information from low-resolution experimental methods. In this review, we describe integrative modeling approaches, which use complementary data from either cryo-EM or SAXS. Specifically, we focus on the popular molecular dynamics flexible fitting (MDFF method, which has been widely used for flexible fitting into cryo-EM maps. Second, we describe hybrid molecular dynamics, Rosetta Monte-Carlo and minimum ensemble search (MES methods that can be used to incorporate SAXS into pseudoatomic structural models. We present concise descriptions of the two methods and their most popular alternatives, along with select illustrative applications to protein/nucleic acid assemblies involved in DNA replication and repair.

  7. Integration of Detectors Into a Large Experiment: Examples From ATLAS and CMS

    CERN Document Server

    Froidevaux, D

    2011-01-01

    Integration of Detectors Into a Large Experiment: Examples From ATLAS andCMS, part of 'Landolt-Börnstein - Group I Elementary Particles, Nuclei and Atoms: Numerical Data and Functional Relationships in Science and Technology, Volume 21B2: Detectors for Particles and Radiation. Part 2: Systems and Applications'. This document is part of Part 2 'Principles and Methods' of Subvolume B 'Detectors for Particles and Radiation' of Volume 21 'Elementary Particles' of Landolt-Börnstein - Group I 'Elementary Particles, Nuclei and Atoms'. It contains the Chapter '5 Integration of Detectors Into a Large Experiment: Examples From ATLAS and CMS' with the content: 5 Integration of Detectors Into a Large Experiment: Examples From ATLAS and CMS 5.1 Introduction 5.1.1 The context 5.1.2 The main initial physics goals of ATLAS and CMS at the LHC 5.1.3 A snapshot of the current status of the ATLAS and CMS experiments 5.2 Overall detector concept and magnet systems 5.2.1 Overall detector concept 5.2.2 Magnet systems 5.2.2.1 Rad...

  8. Observing with a space-borne gamma-ray telescope: selected results from INTEGRAL

    CERN Document Server

    Schanne, S

    2006-01-01

    The International Gamma-Ray Astrophysics Laboratory, i.e. the INTEGRAL satellite of ESA, in orbit since about 3 years, performs gamma-ray observations of the sky in the 15 keV to 8 MeV energy range. Thanks to its imager IBIS, and in particular the ISGRI detection plane based on 16384 CdTe pixels, it achieves an excellent angular resolution (12 arcmin) for point source studies with good continuum spectrum sensitivity. Thanks to its spectrometer SPI, based on 19 germanium detectors maintained at 85 K by a cryogenic system, located inside an active BGO veto shield, it achieves excellent spectral resolution of about 2 keV for 1 MeV photons, which permits astrophysical gamma-ray line studies with good narrow-line sensitivity. In this paper we review some goals of gamma-ray astronomy from space and present the INTEGRAL satellite, in particular its instruments ISGRI and SPI. Ground and in-flight calibration results from SPI are presented, before presenting some selected astrophysical results from INTEGRAL. In partic...

  9. From the phenomenology to the mechanisms of consciousness: Integrated Information Theory 3.0.

    Science.gov (United States)

    Oizumi, Masafumi; Albantakis, Larissa; Tononi, Giulio

    2014-05-01

    This paper presents Integrated Information Theory (IIT) of consciousness 3.0, which incorporates several advances over previous formulations. IIT starts from phenomenological axioms: information says that each experience is specific--it is what it is by how it differs from alternative experiences; integration says that it is unified--irreducible to non-interdependent components; exclusion says that it has unique borders and a particular spatio-temporal grain. These axioms are formalized into postulates that prescribe how physical mechanisms, such as neurons or logic gates, must be configured to generate experience (phenomenology). The postulates are used to define intrinsic information as "differences that make a difference" within a system, and integrated information as information specified by a whole that cannot be reduced to that specified by its parts. By applying the postulates both at the level of individual mechanisms and at the level of systems of mechanisms, IIT arrives at an identity: an experience is a maximally irreducible conceptual structure (MICS, a constellation of concepts in qualia space), and the set of elements that generates it constitutes a complex. According to IIT, a MICS specifies the quality of an experience and integrated information ΦMax its quantity. From the theory follow several results, including: a system of mechanisms may condense into a major complex and non-overlapping minor complexes; the concepts that specify the quality of an experience are always about the complex itself and relate only indirectly to the external environment; anatomical connectivity influences complexes and associated MICS; a complex can generate a MICS even if its elements are inactive; simple systems can be minimally conscious; complicated systems can be unconscious; there can be true "zombies"--unconscious feed-forward systems that are functionally equivalent to conscious complexes.

  10. Cue integration in categorical tasks: insights from audio-visual speech perception.

    Directory of Open Access Journals (Sweden)

    Vikranth Rao Bejjanki

    Full Text Available Previous cue integration studies have examined continuous perceptual dimensions (e.g., size and have shown that human cue integration is well described by a normative model in which cues are weighted in proportion to their sensory reliability, as estimated from single-cue performance. However, this normative model may not be applicable to categorical perceptual dimensions (e.g., phonemes. In tasks defined over categorical perceptual dimensions, optimal cue weights should depend not only on the sensory variance affecting the perception of each cue but also on the environmental variance inherent in each task-relevant category. Here, we present a computational and experimental investigation of cue integration in a categorical audio-visual (articulatory speech perception task. Our results show that human performance during audio-visual phonemic labeling is qualitatively consistent with the behavior of a Bayes-optimal observer. Specifically, we show that the participants in our task are sensitive, on a trial-by-trial basis, to the sensory uncertainty associated with the auditory and visual cues, during phonemic categorization. In addition, we show that while sensory uncertainty is a significant factor in determining cue weights, it is not the only one and participants' performance is consistent with an optimal model in which environmental, within category variability also plays a role in determining cue weights. Furthermore, we show that in our task, the sensory variability affecting the visual modality during cue-combination is not well estimated from single-cue performance, but can be estimated from multi-cue performance. The findings and computational principles described here represent a principled first step towards characterizing the mechanisms underlying human cue integration in categorical tasks.

  11. From the phenomenology to the mechanisms of consciousness: Integrated Information Theory 3.0.

    Directory of Open Access Journals (Sweden)

    Masafumi Oizumi

    2014-05-01

    Full Text Available This paper presents Integrated Information Theory (IIT of consciousness 3.0, which incorporates several advances over previous formulations. IIT starts from phenomenological axioms: information says that each experience is specific--it is what it is by how it differs from alternative experiences; integration says that it is unified--irreducible to non-interdependent components; exclusion says that it has unique borders and a particular spatio-temporal grain. These axioms are formalized into postulates that prescribe how physical mechanisms, such as neurons or logic gates, must be configured to generate experience (phenomenology. The postulates are used to define intrinsic information as "differences that make a difference" within a system, and integrated information as information specified by a whole that cannot be reduced to that specified by its parts. By applying the postulates both at the level of individual mechanisms and at the level of systems of mechanisms, IIT arrives at an identity: an experience is a maximally irreducible conceptual structure (MICS, a constellation of concepts in qualia space, and the set of elements that generates it constitutes a complex. According to IIT, a MICS specifies the quality of an experience and integrated information ΦMax its quantity. From the theory follow several results, including: a system of mechanisms may condense into a major complex and non-overlapping minor complexes; the concepts that specify the quality of an experience are always about the complex itself and relate only indirectly to the external environment; anatomical connectivity influences complexes and associated MICS; a complex can generate a MICS even if its elements are inactive; simple systems can be minimally conscious; complicated systems can be unconscious; there can be true "zombies"--unconscious feed-forward systems that are functionally equivalent to conscious complexes.

  12. From the Phenomenology to the Mechanisms of Consciousness: Integrated Information Theory 3.0

    Science.gov (United States)

    Tononi, Giulio

    2014-01-01

    This paper presents Integrated Information Theory (IIT) of consciousness 3.0, which incorporates several advances over previous formulations. IIT starts from phenomenological axioms: information says that each experience is specific – it is what it is by how it differs from alternative experiences; integration says that it is unified – irreducible to non-interdependent components; exclusion says that it has unique borders and a particular spatio-temporal grain. These axioms are formalized into postulates that prescribe how physical mechanisms, such as neurons or logic gates, must be configured to generate experience (phenomenology). The postulates are used to define intrinsic information as “differences that make a difference” within a system, and integrated information as information specified by a whole that cannot be reduced to that specified by its parts. By applying the postulates both at the level of individual mechanisms and at the level of systems of mechanisms, IIT arrives at an identity: an experience is a maximally irreducible conceptual structure (MICS, a constellation of concepts in qualia space), and the set of elements that generates it constitutes a complex. According to IIT, a MICS specifies the quality of an experience and integrated information ΦMax its quantity. From the theory follow several results, including: a system of mechanisms may condense into a major complex and non-overlapping minor complexes; the concepts that specify the quality of an experience are always about the complex itself and relate only indirectly to the external environment; anatomical connectivity influences complexes and associated MICS; a complex can generate a MICS even if its elements are inactive; simple systems can be minimally conscious; complicated systems can be unconscious; there can be true “zombies” – unconscious feed-forward systems that are functionally equivalent to conscious complexes. PMID:24811198

  13. Changes in white matter integrity before conversion from mild cognitive impairment to Alzheimer's disease.

    Directory of Open Access Journals (Sweden)

    Michaela Defrancesco

    Full Text Available Mild cognitive impairment (MCI may represent an early stage of dementia conferring a particularly high annual risk of 15-20% of conversion to Alzheimer's disease (AD. Recent findings suggest that not only gray matter (GM loss but also a decline in white matter (WM integrity may be associated with imminent conversion from MCI to AD.In this study we used Voxel-based morphometry (VBM to examine if gray matter loss and/or an increase of the apparent diffusion coefficient (ADC reflecting mean diffusivity (MD are an early marker of conversion from MCI to AD in a high risk population.Retrospective neuropsychological and clinical data were collected for fifty-five subjects (MCI converters n = 13, MCI non-converters n = 14, healthy controls n = 28 at baseline and one follow-up visit. All participants underwent diffusion weighted imaging (DWI and T1-weighted structural magnetic resonance imaging scans at baseline to analyse changes in GM density and WM integrity using VBM.At baseline MCI converters showed impaired performance in verbal memory and naming compared to MCI non-converters. Further, MCI converters showed decreased WM integrity in the frontal, parietal, occipital, as well as the temporal lobe prior to conversion to AD. Multiple regression analysis showed a positive correlation of gray matter atrophy with specific neuropsychological test results.Our results suggest that additionally to morphological changes of GM a reduced integrity of WM indicates an imminent progression from MCI stage to AD. Therefore, we suggest that DWI is useful in the early diagnosis of AD.

  14. Integrated Results from Analysis of the Rocknest Aeolian Deposit by the Curiosity Rover

    Science.gov (United States)

    Leshin, L. A.; Grotzinger, J. P.; Blake, D. F.; Edgett, K. S.; Gellert, R.; Mahaffy, P. R.; Malin, M. C.; Wiens, R. C.; Treiman, A. H.; Ming, D. W.; Eigenbrode, J.

    2013-01-01

    The Mars Science Laboratory Curiosity rover spent 45 sols (from sol 56-101) at an area called Rocknest (Fig. 1), characterizing local geology and ingesting its aeolian fines into the analytical instruments CheMin and SAM for mineralogical and chemical analysis. Many abstracts at this meeting present the contextual information and detailed data on these first solid samples analyzed in detail by Curiosity at Rocknest. Here, we present an integrated view of the results from Rocknest - the general agreement from discussions among the entire MSL Science Team.

  15. An economic benefit deriving from space activities: Integration between science institutions and industry

    Science.gov (United States)

    Monti, R.; D'Amore, M.; D'Angelo, L.

    1993-09-01

    A lively debate is taking place in Italy on the assessment of the economic benefits deriving from the national expenditure in space programmes. Specific studies have been recently committed by the Italian Space Agency on this subject. This paper aims at providing an original insight in this debate by focusing on the often underestimated effect that the development of space programmes has on the process of integration of university, research centres and industry. In fact, the economic analysis of the technology innovation evidences that the integration of research institutions and industry represents a key issue in the establishment of an effective national innovation system towards a higher industrial competitiveness. It is widely recognized that the initiation and promotion of the process of integration of industry and research institutions is primarily dependent on their cooperation within large public funded programmes in the field of high technology. Do space programmes show any peculiarity which make them especially suitable to generate an effective cooperation between industry and science institutions? The major goal of this paper will be to give an answer to this question through the analysis of the main characteristics of space programmes as far as the integration process is concerned. Space programmes will then be analysed identifying the critical aspects related to the process of research and technology development. Following, it will be demonstrated to which extent cooperation between industry and science institutions has been helpful in solving the identified critical aspects. The analysis will also address the organizational issues in order to identify the cooperation modes. Furthermore, an attempt will be made to assess the benefits deriving from the identified forms of cooperation in view of an increasing integration between industry and science institutions. The analysis will then be focused on the microgravity field; in fact, on the basis of the

  16. Teachings From the Deep South: North-South Contributions to Integral Education

    Directory of Open Access Journals (Sweden)

    Adrian Villasenor-Galarza

    2011-06-01

    Full Text Available The present paper addresses the need to incorporate often ignored perspectives and formulations derived from what I refer to as the “deep south” into the field of integral education as currently practiced at the California Institute of Integra Studies (CIIS, in San Francisco, CA. The deep south, or the metaphorical conglomerate of wisdom ascribed to the global south and associated epistemologies, is used as a broad framework from which I propose, through the exploration of shamanic practices and symbols, the creation of an organizing vertical metaphor, a North–South axis of dialogue. I start with a brief exposition of the one of the main challenges that integral education faces, a cognicentric focus, and proceed to explore alternatives to it by addressing some repressed aspects of the field, the notion of multidimensionality, and the symbol of the axis mundi. The paper ends with an invitation for a marriage to take place between the East–West and North–South axes of knowing and learning as an adequate and necessary development for integral education.

  17. West Nile virus transmission: results from the integrated surveillance system in Italy, 2008 to 2015

    Science.gov (United States)

    Rizzo, Caterina; Napoli, Christian; Venturi, Giulietta; Pupella, Simonetta; Lombardini, Letizia; Calistri, Paolo; Monaco, Federica; Cagarelli, Roberto; Angelini, Paola; Bellini, Romeo; Tamba, Marco; Piatti, Alessandra; Russo, Francesca; Palù, Giorgio; Chiari, Mario; Lavazza, Antonio; Bella, Antonino

    2016-01-01

    In Italy a national Plan for the surveillance of imported and autochthonous human vector-borne diseases (chikungunya, dengue, Zika virus disease and West Nile virus (WNV) disease) that integrates human and veterinary (animals and vectors) surveillance, is issued and revised annually according with the observed epidemiological changes. Here we describe results of the WNV integrated veterinary and human surveillance systems in Italy from 2008 to 2015. A real time data exchange protocol is in place between the surveillance systems to rapidly identify occurrence of human and animal cases and to define and update the map of affected areas i.e. provinces during the vector activity period from June to October. WNV continues to cause severe illnesses in Italy during every transmission season, albeit cases are sporadic and the epidemiology varies by virus lineage and geographic area. The integration of surveillance activities and a multidisciplinary approach made it possible and have been fundamental in supporting implementation of and/or strengthening preventive measures aimed at reducing the risk of transmission of WNV trough blood, tissues and organ donation and to implementing further measures for vector control. PMID:27684046

  18. Reduced audiovisual integration in synesthesia--evidence from bimodal speech perception.

    Science.gov (United States)

    Sinke, Christopher; Neufeld, Janina; Zedler, Markus; Emrich, Hinderk M; Bleich, Stefan; Münte, Thomas F; Szycik, Gregor R

    2014-03-01

    Recent research suggests synesthesia as a result of a hypersensitive multimodal binding mechanism. To address the question whether multimodal integration is altered in synesthetes in general, grapheme-colour and auditory-visual synesthetes were investigated using speech-related stimulation in two behavioural experiments. First, we used the McGurk illusion to test the strength and number of illusory perceptions in synesthesia. In a second step, we analysed the gain in speech perception coming from seen articulatory movements under acoustically noisy conditions. We used disyllabic nouns as stimulation and varied signal-to-noise ratio of the auditory stream presented concurrently to a matching video of the speaker. We hypothesized that if synesthesia is due to a general hyperbinding mechanism this group of subjects should be more susceptible to McGurk illusions and profit more from the visual information during audiovisual speech perception. The results indicate that there are differences between synesthetes and controls concerning multisensory integration--but in the opposite direction as hypothesized. Synesthetes showed a reduced number of illusions and had a reduced gain in comprehension by viewing matching articulatory movements in comparison to control subjects. Our results indicate that rather than having a hypersensitive binding mechanism, synesthetes show weaker integration of vision and audition. © 2012 The British Psychological Society.

  19. West Nile virus transmission: results from the integrated surveillance system in Italy, 2008 to 2015.

    Science.gov (United States)

    Rizzo, Caterina; Napoli, Christian; Venturi, Giulietta; Pupella, Simonetta; Lombardini, Letizia; Calistri, Paolo; Monaco, Federica; Cagarelli, Roberto; Angelini, Paola; Bellini, Romeo; Tamba, Marco; Piatti, Alessandra; Russo, Francesca; Palù, Giorgio; Chiari, Mario; Lavazza, Antonio; Bella, Antonino

    2016-09-15

    In Italy a national Plan for the surveillance of imported and autochthonous human vector-borne diseases (chikungunya, dengue, Zika virus disease and West Nile virus (WNV) disease) that integrates human and veterinary (animals and vectors) surveillance, is issued and revised annually according with the observed epidemiological changes. Here we describe results of the WNV integrated veterinary and human surveillance systems in Italy from 2008 to 2015. A real time data exchange protocol is in place between the surveillance systems to rapidly identify occurrence of human and animal cases and to define and update the map of affected areas i.e. provinces during the vector activity period from June to October. WNV continues to cause severe illnesses in Italy during every transmission season, albeit cases are sporadic and the epidemiology varies by virus lineage and geographic area. The integration of surveillance activities and a multidisciplinary approach made it possible and have been fundamental in supporting implementation of and/or strengthening preventive measures aimed at reducing the risk of transmission of WNV trough blood, tissues and organ donation and to implementing further measures for vector control.

  20. Integration of Ethics across the Curriculum: From First Year through Senior Seminar.

    Science.gov (United States)

    Gasparich, Gail E; Wimmers, Larry

    2014-12-01

    The Fisher College of Science and Mathematics (FCSM) at Towson University (TU) has integrated authentic research experiences throughout the curriculum from first year STEM courses through advanced upper-level classes and independent research. Our observation is that training in both responsible conduct of research (RCR) and bioethics throughout the curriculum was an effective strategy to advance the cognitive and psychosocial development of the students. As students enter TU they generally lack the experience and tools to assess their own competence, to apply ethical debates, to investigate scientific topics from an ethical perspective, or to integrate ethics into final conclusions. Student behavior and development follow cognitive models such as described in the theories put forth by Piaget, Kohlberg, and Erikson, both for initial learning and for how concepts are understood and adopted. Three examples of this ethics training integration are described, including a cohort-based course for first year students in the STEM Residential Learning Community, a cohort-based course for community college students that are involved in an NIH-funded Bridges to the Baccalaureate program, and a senior seminar in Bioethics in the Molecular Biology, Biochemistry and Bioinformatics Program. All three focus on different aspects of RCR and bioethics training, providing opportunities for students to learn about the principles of effective decision-making, critical and analytical thinking, problem solving, and communication with increasing degrees of complexity as they move through the curriculum.

  1. Integration of Ethics across the Curriculum: From First Year through Senior Seminar

    Directory of Open Access Journals (Sweden)

    Gail E. Gasparich

    2014-10-01

    Full Text Available The Fisher College of Science and Mathematics (FCSM at Towson University (TU has integrated authentic research experiences throughout the curriculum from first year STEM courses through advanced upper-level classes and independent research. Our observation is that training in both responsible conduct in research (RCR and bioethics throughout the curriculum was an effective strategy to advance the cognitive and psychosocial development of the students. As students enter TU they generally lack the experience and tools to assess their own competence, to apply ethical debates, to investigate scientific topics from an ethical perspective, or to integrate ethics into final conclusions. Student behavior and development follow cognitive models such as described in the theories put forth by Piaget, Kohlberg, and Erikson, both for initial learning and for how concepts are understood and adopted. Three examples of this ethics training integration are described, including a cohort-based course for first year students in the STEM Residential Learning Community, a cohort-based course for community college students that are involved in an NIH-funded Bridges to the Baccalaureate program, and a senior seminar in Bioethics in the Molecular Biology, Biochemistry and Bioinformatics Program. All three focus on different aspects of RCR and bioethics training, providing opportunities for students to learn about the principles of effective decision-making, critical and analytical thinking, problem solving, and communication with increasing degrees of complexity as they move through the curriculum.

  2. Integrating Variable Renewable Energy in Electric Power Markets: Best Practices from International Experience

    Energy Technology Data Exchange (ETDEWEB)

    Cochran, J.; Bird, L.; Heeter, J.; Arent, D. A.

    2012-04-01

    Many countries -- reflecting very different geographies, markets, and power systems -- are successfully managing high levels of variable renewable energy on the electric grid, including that from wind and solar energy. This study documents the diverse approaches to effective integration of variable renewable energy among six countries -- Australia (South Australia), Denmark, Germany, Ireland, Spain, and the United States (Western region-Colorado and Texas)-- and summarizes policy best practices that energy ministers and other stakeholders can pursue to ensure that electricity markets and power systems can effectively coevolve with increasing penetrations of variable renewable energy. Each country has crafted its own combination of policies, market designs, and system operations to achieve the system reliability and flexibility needed to successfully integrate renewables. Notwithstanding this diversity, the approaches taken by the countries studied all coalesce around five strategic areas: lead public engagement, particularly for new transmission; coordinate and integrate planning; develop rules for market evolution that enable system flexibility; expand access to diverse resources and geographic footprint of operations; and improve system operations. The ability to maintain a broad ecosystem perspective, to organize and make available the wealth of experiences, and to ensure a clear path from analysis to enactment should be the primary focus going forward.

  3. Processes and Outcomes from a Medical Student Research Training Program in Integrative, Complementary, and Alternative Medicine.

    Science.gov (United States)

    Dicianno, Brad E; Glick, Ronald M; Sowa, Gwendolyn A; Boninger, Michael L

    2016-10-01

    In response to the growing need to train a new generation of clinician scientists, a research program was developed to train medical students in integrative, complementary, and alternative medicine (ICAM) research early in their careers. A total of 25 students (100%) successfully completed a 10-week program. Students reported significantly increased levels of knowledge in all 7 integrative, complementary, and alternative medicine topics at the conclusion of the program. All students presented their work at one or more local research symposia. In addition, the average number of quality research outputs, which included manuscripts, awards, and abstracts presented at national and international meetings, was 1.5 per student, which exceeded benchmarks based on prior program outcomes. Results from this program may be useful when planning larger or longer-term projects aimed at attracting physicians who will become our next generation of academicians, researchers, and healers.

  4. Moving from silos to teamwork: integration of interprofessional trainees into a medical home model.

    Science.gov (United States)

    Long, Theodore; Dann, Sarah; Wolff, Marissa Lynn; Brienza, Rebecca S

    2014-09-01

    As the United States faces an impending shortage in the primary care workforce, interprofessional teamwork training to improve clinic efficiency and health outcomes is becoming increasingly important. Currently there is limited integration of interprofessional training in educational models for health professionals. The implementation of Patient Aligned Care Teams at the Department of Veterans Affairs (VA) has provided an opportunity for interprofessional collaboration among trainee and faculty providers within the VA system. However, integration of interprofessional education is also necessary to train future providers in order to provide effective team-based care. We describe a transportable educational model for health professional collaboration from our experience as a VA Center of Excellence in Primary Care Education, including a complementary novel one-year post-Master's adult nurse practitioner interprofessional clinical fellowship. With growing recognition that interprofessional care can improve efficiency and outcomes, there is an increasing need for programs that train future providers in collaboration and team-based care.

  5. Distress from Motivational Dis-integration: When Fundamental Motives Are Too Weak or Too Strong.

    Science.gov (United States)

    Cornwell, James F M; Franks, Becca; Higgins, E Tory

    2016-01-01

    Past research has shown that satisfying different kinds of fundamental motives contributes to well-being. More recently, advances in motivational theory have shown that z is also tied to the integration of different motives. In other words, well-being depends not only on maximizing effectiveness in satisfying specific motives, but also on ensuring that motives work together such that no individual motive is too weak or too strong. In this chapter, we review existing research to show that specific forms of psychological distress can be linked to specific types of motivational imbalance or dis-integration. Such disintegration can arise from either excessive weakness of a specific motive or the excessive strength and/or dominance of a specific motive, thereby inhibiting other motives. Possible neural correlates and avenues of intervention are discussed.

  6. INTEGRAL/JEM-X detection of fading emission from GT Mus

    DEFF Research Database (Denmark)

    Fiocchi, M.; Chenevez, J.; Sguera, V.;

    2015-01-01

    On November 15th 2015 the MAXI/GSC detected a big flare from the RS CVn star GT Mus with a flux of ~100 mCrab in the 2-20 keV energy band. (ATel #8285). During recent INTEGRAL observations of the Musca region performed between 17 Nov 16:08 and 18 Nov 00:05 (UTC) the source GT Mus was within...... a 3 sigma upper limit of about 25 mCrab in the 18-40 keV energy range. In addition, INTEGRAL observed the Musca region on Nov 12 2015 between 11:14 and 17:11 (UTC) and the source was not significantly detected by JEM-X. We derive a 5-sigma upper limit of 4 mCrab (3-10 keV) for a net exposure time...

  7. [Political-academic discourse and integration of handicapped people: from appearances to the senses].

    Science.gov (United States)

    de França, Inacia Sátiro; Pagliuca, Lorita Marlena; de Sousa, Rosiléa Alves

    2003-12-01

    Our aim was to analyze law no. 3.298/99 and course plans in undergraduate nursing programs in order to confirm the inclusion of the item for participation of nurses in the Handicapped People (HP) integration process. We read the plans of courses from four universities; identified the courses in common and distributed them according to the level of health care. The proposals of the law are universal, equal, and democratic; the plans of courses analyzed adopt most of the actions recommended by the Ministry of Health in order to prevent deficiencies. Nevertheless, academic practice exercises prevention/treatment of diseases, silencing concern over the insertion of nurse in the HP integration process.

  8. From moral theory to penal attitudes and back: a theoretically integrated modeling approach.

    Science.gov (United States)

    de Keijser, Jan W; van der Leeden, Rien; Jackson, Janet L

    2002-01-01

    From a moral standpoint, we would expect the practice of punishment to reflect a solid and commonly shared legitimizing framework. Several moral legal theories explicitly aim to provide such frameworks. Based on the theories of Retributivism, Utilitarianism, and Restorative Justice, this article first sets out to develop a theoretically integrated model of penal attitudes and then explores the extent to which Dutch judges' attitudes to punishment fit the model. Results indicate that penal attitudes can be measured in a meaningful way that is consistent with an integrated approach to moral theory. The general structure of penal attitudes among Dutch judges suggests a streamlined and pragmatic approach to legal punishment that is identifiably founded on the separate concepts central to moral theories of punishment. While Restorative Justice is frequently presented as an alternative paradigm, results show it to be smoothly incorporated within the streamlined approach.

  9. From path integrals to tensor networks for the AdS /CFT correspondence

    Science.gov (United States)

    Miyaji, Masamichi; Takayanagi, Tadashi; Watanabe, Kento

    2017-03-01

    In this paper, we discuss tensor network descriptions of AdS /CFT from two different viewpoints. First, we start with a Euclidean path-integral computation of ground state wave functions with a UV cutoff. We consider its efficient optimization by making its UV cutoff position dependent and define a quantum state at each length scale. We conjecture that this path integral corresponds to a time slice of anti-de Sitter (AdS) spacetime. Next, we derive a flow of quantum states by rewriting the action of Killing vectors of AdS3 in terms of the dual two-dimensional conformal field theory (CFT). Both approaches support a correspondence between the hyperbolic time slice H2 in AdS3 and a version of continuous multiscale entanglement renormalization ansatz. We also give a heuristic argument about why we can expect a sub-AdS scale bulk locality for holographic CFTs.

  10. Lost in translation: data integration tools meet the Semantic Web (experiences from the Ondex project)

    CERN Document Server

    Splendiani, Andrea; Kuo, Shao-Chih; Stevens, Robert; Lord, Phillip

    2011-01-01

    More information is now being published in machine processable form on the web and, as de-facto distributed knowledge bases are materializing, partly encouraged by the vision of the Semantic Web, the focus is shifting from the publication of this information to its consumption. Platforms for data integration, visualization and analysis that are based on a graph representation of information appear first candidates to be consumers of web-based information that is readily expressible as graphs. The question is whether the adoption of these platforms to information available on the Semantic Web requires some adaptation of their data structures and semantics. Ondex is a network-based data integration, analysis and visualization platform which has been developed in a Life Sciences context. A number of features, including semantic annotation via ontologies and an attention to provenance and evidence, make this an ideal candidate to consume Semantic Web information, as well as a prototype for the application of netw...

  11. Modeling community integration in workers with delayed recovery from mild traumatic brain injury

    DEFF Research Database (Denmark)

    Mollayeva, T.; Shapiro, C. M.; Mollayeva, S.

    2015-01-01

    Background: Delayed recovery in persons after mild traumatic brain injury (mTBI) is poorly understood. Community integration (CI) is endorsed by persons with neurological disorders as an important outcome. We aimed to describe CI and its associated factors in insured Ontario workers with delayed...... recovery following mTBI. Methods: A cross-sectional study of insured workers in the chronic phase following mTBI was performed at a rehabilitation hospital in Ontario, Canada. Sociodemographic, occupational, injury-related, clinical, and claim-related data were collected from self-reports, medical...... assessments, and insurers' referral files. Community Integration Questionnaire (CIQ) scores were compared using analysis of variance or Spearman's correlation tests. Stepwise multivariable linear regression models were used to evaluate the associations with CI. Results: Ninety-four workers with mTBI (45...

  12. Cost and quality gains from diversification and vertical integration in the electricity industry: A DEA approach

    Energy Technology Data Exchange (ETDEWEB)

    Arocena, Pablo [Universidad Publica de Navarra, Dpto. Gestion de Empresas, Campus de Arrosadia, 31006 Pamplona (Spain)

    2008-01-15

    This paper analyzes the degree of economies of vertical integration, diversification and scale in the electricity industry by means of Data Envelopment Analysis. We estimate the impact that alternative forms of unbundling would have on the cost and quality of supply, measured as the number and duration of supply interruptions, in a group of Spanish electric utilities. We find evidence of the existence of cost and quality gains from integrating power generation and distribution in the range of 1.1 to 4.9%, whereas diversifying the source of power generation saves between 1.3 and 4.3% of costs and quality. Finally, the scale efficiency of the largest utilities could be improved by dividing them into smaller units, provided that their current vertical scope and generation-mix are preserved. (author)

  13. Solazyme Integrated Biorefinery (SzIBR): Diesel Fuels from Heterotrophic Algae

    Energy Technology Data Exchange (ETDEWEB)

    Brinkmann, David [Solazyme, Inc., South San Francisco, CA (United States)

    2014-12-23

    Under Department of Energy Award Number DE-EE0002877 (the “DOE Award”), Solazyme, Inc. (“Solazyme”) has built a demonstration scale “Solazyme Integrated Biorefinery (SzlBR).” The SzIBR was built to provide integrated scale-up of Solazyme’s novel heterotrophic algal oil biomanufacturing process, validate the projected commercial-scale economics of producing multiple algal oils, and to enable Solazyme to collect the data necessary to complete the design of its first commercial-scale facility. Solazyme’s technology enables it to convert a range of low-cost plant-based sugars into high-value oils. Solazyme’s renewable products replace or enhance oils derived from the world’s three existing sources—petroleum, plants, and animal fats. Solazyme tailors the composition of its oils to address specific customer requirements, offering superior performance characteristics and value. This report summarizes history and the results of the project.

  14. Recommendations for Development of Rural Labor Service Economy from the Perspective of Urban and Rural Integration

    Institute of Scientific and Technical Information of China (English)

    Hua; ZHANG

    2014-01-01

    Rural labor service economy is a method turning rural surplus human resources to economic resources,to realize increase of social wealth. Developing the rural labor service economy has profound influence on promoting transfer and employment of rural surplus labor,and speeding up industrialization and urbanization. Rural labor service economy is a huge and complex systematic project for promoting urban and rural integrated development and increasing farmers’ income. This paper firstly analyzed importance and urgency of accelerating the development of rural labor service economy. From the perspective of urban and rural integration,it came up with pertinent recommendations,including establishing security mechanism and improving rural labor security mechanism,creating preferential conditions and encouraging farmers to return to hometown,exploring potential and promoting nearby labor transfer to promote rapid economic development,improving public employment service system,and cultivating and developing labor market. It is expected to provide certain references.

  15. The Effect of Headquarter Integration Mechanisms on Subsidiaries’ New Product Success: From Control to Coordination Mechanism

    Directory of Open Access Journals (Sweden)

    Firmanzah

    2007-10-01

    Full Text Available New product launching (NPL to the local market by subsidiary managers is a strategic activity, which requires organizational supports from MNC global network. The NPL activity is marked by high level of uncertainty, risk, and market failure. Thus, a headquarter needs to integrate the subsidiary NPL into global strategy. There are two mechanisms to integrate subsidiaries’ activities during NPL process; coordination and control process. By testing the effect of each mechanism on role clarity and functional conflict, I found that coordination mechanism increase role clarity between headquarter and subsidiaries’ managers. In contrast, exercising control mechanism reduces role clarity and functional conflict between headquarter and subsidiaries’ managers during NPL. This research shows that both role clarity and functional conflict increase new product commercial performance introduced by subsidiary in the local market.

  16. From molecules to behavior: An integrative theory of autism spectrum disorder.

    Science.gov (United States)

    Niculae, Alexandru-Ştefan; Pavăl, Denis

    2016-12-01

    Autism spectrum disorder (ASD) comprises a group of neurodevelopmental disorders for which various theories have been proposed. Each theory brings valuable insights and has experimental evidence backing it, yet none provides an overarching explanation for each of the pathological aspects involved in ASD. Here we present an integrative theory of ASD, centered on a sequence of events spanning from the molecular to the behavioral level. We propose that an abnormality in the interplay between retinoic acid and sex hormones predisposes an individual to specific molecular malfunctions. In turn, this molecular syndrome generates an altered brain connectivity between the cerebellum, the midbrain dopaminergic areas, and the prefrontal cortex. Lastly, this disconnection would generate specific behavioral traits traditionally involved in ASD. Therefore, this paper represents a step forward in unifying different levels of pathological features into novel integrated testable hypotheses.

  17. From Path Integrals to Tensor Networks for AdS/CFT

    CERN Document Server

    Miyaji, Masamichi; Watanabe, Kento

    2016-01-01

    In this paper, we discuss tensor network descriptions of AdS/CFT from two different viewpoints. First, we start with an Euclidean path-integral computation of ground state wave functions with a UV cut off. We consider its efficient optimization by making its UV cut off position dependent and define a quantum state at each length scale. We conjecture that this path-integral corresponds to a time slice of AdS. Next, we derive a flow of quantum states by rewriting the action of Killing vectors of AdS3 in terms of the dual 2d CFT. Both approaches support a correspondence between the hyperbolic time slice H2 in AdS3 and a version of continuous MERA (cMERA). We also give a heuristic argument why we can expect a sub-AdS scale bulk locality for holographic CFTs.

  18. A Model for Integrating Computation in Undergraduate Physics: An example from middle-division classical mechanics

    CERN Document Server

    Caballero, Marcos D

    2013-01-01

    Much of the research done by modern physicists would be impossible without the use of computation. And yet, while computation is a crucial tool of practicing physicists, physics curricula do not generally reflect its importance and utility. To more tightly connect undergraduate preparation with professional practice, we integrated computational instruction into middle-division classical mechanics at the University of Colorado Boulder. Our model for integration includes the construction of computational learning goals, the design of computational activities consistent with those goals, and the assessment of students' computational fluency. To assess students' computational fluency, we used open-ended computational projects in which students prepared reports describing a physical problem of their choosing. Many students chose projects from outside the domain of the course, and therefore, had to employ mathematical and computational techniques they had not yet been taught. After completing the project, most stud...

  19. Reduction of Integral Field Spectroscopic Data from the Gemini Multi-Object Spectrograph (a commented example)

    CERN Document Server

    Lena, Davide

    2014-01-01

    The use of integral field spectroscopy is becoming increasingly popular, hovewer data reduction is still a difficult process. Here I present a step-by-step guide to the reduction of integral field data acquired with the Gemini Multi-Object Spectrograph (GMOS) on GEMINI. The reduction process, separately applied to a standard star and to the science data, includes bias and sky subtraction, flat-fielding, trimming, wavelength and flux calibration, creation of the cubes for each exposure and final combination into a single cube. Typical problems encoutered during the reduction process are discussed. The command list has been adapted from IRAF scripts given as tutorials at the South American Gemini Data Workshop (S\\~{a}o Jos\\'e dos Campos, Brazil, October 27-30, 2011) and scripts kindly provided by collaborators.

  20. INTEGRAL/SPI Limits on Electron-Positron Annihilation Radiation from the Galactic Plane

    CERN Document Server

    Teegarden, B J; Jean, P; Knödlseder, J; Lonjou, V; Roques, J P; Skinner, G K; Von Ballmoos, P; Weidenspointner, G; Bazzano, A; Butt, Y M; Decourchelle, A; Fabian, A C; Goldwurm, A; Güdel, M; Hannikainen, D C; Hartmann, D H; Hornstrup, A; Lewin, W H G; Makishima, K; Malzac, A; Miller, J; Parmar, A N; Reynolds, S P; Rothschild, R E; Tomsick, J A; Vink, J

    2004-01-01

    The center of our Galaxy is a known strong source of electron-positron 511-keV annihilation radiation. Thus far, however, there have been no reliable detections of annihilation radiation outside of the central radian of our Galaxy. One of the primary objectives of the INTEGRAL (INTErnational Gamma-RAy Astrophysics Laboratory) mission, launched in Oct. 2002, is the detailed study of this radiation. The Spectrometer on INTEGRAL (SPI) is a high resolution coded-aperture gamma-ray telescope with an unprecedented combination of sensitivity, angular resolution and energy resolution. We report results from the first 10 months of observation. During this period a significant fraction of the observing time was spent in or near the Galactic Plane. No positive annihilation flux was detected outside of the central region (|l| > 40 deg) of our Galaxy. In this paper we describe the observations and data analysis methods and give limits on the 511-keV flux.