WorldWideScience

Sample records for naise viljatus 1-2

  1. Küülik kübarast, sperma naise tüvirakkudest / Maris Meiessaar

    Index Scriptorium Estoniae

    Meiessaar, Maris

    2008-01-01

    Briti teadlased on valmis muutma naise luuüdi spermaks ning mehi sellega elu loomise protsessist kõrvale jätma. Newcastle upon Tyneѫi ülikooli teadlased loodavad oma tehnikast abi viljatuse ravimiseks

  2. Küülik kübarast, sperma naise tüvirakkudest / Maris Meiessaar

    Index Scriptorium Estoniae

    Meiessaar, Maris

    2008-01-01

    Briti teadlased on valmis muutma naise luuüdi spermaks ning mehi sellega elu loomise protsessist kõrvale jätma. Newcastle upon Tyneѫi ülikooli teadlased loodavad oma tehnikast abi viljatuse ravimiseks

  3. Ateneumi kunstikoolid ja naised Eestist / Kai Stahl

    Index Scriptorium Estoniae

    Stahl, Kai

    2010-01-01

    Eestiga seotud naiste haridusteed Ateneumi majas asunud Soome Kunstiühingu Joonistuskoolis ja Rakenduskooli Kõrgemas Kunsttööstuskoolis 1890. aastatest kuni Eesti iseseisvumiseni. Naised kui loojad

  4. Kõigi maade naised on ühinenud / Johannes Saar

    Index Scriptorium Estoniae

    Saar, Johannes, 1965-

    2004-01-01

    Ameerika feministliku kunstniku Claudia DeMonte kuraatoriprojekt "Maailma naised" ja retrospektiivne isiknäitus Tallinna Kunstihoones. Alates 1996. aastast saadeti väljakuulutatud projekti raames kunstnikule 177 maali naisest ja naise olukorrast

  5. Naised teaduses = Women in research / Aavo Heinlo

    Index Scriptorium Estoniae

    Heinlo, Aavo

    2006-01-01

    Naiste osa teadus- ja arendustegevuses. Naised ja mehed akadeemilise karjääri tüüpilistel astmetel Euroopa Liidus ja Eestis. Naiste karjäär ja klaaslae indeks (Glass Ceiling Index), sooline palgalõhe. Tabelid, diagrammid

  6. Naised Idamaalt ja mujalt / Aita Kivi

    Index Scriptorium Estoniae

    Kivi, Aita, 1954-

    2000-01-01

    Sisu : Kazuo Ishiguro. Mägede kahvatu terendus; Anchee Min. Punane asalea; Larissa Vassiljeva. Vene kroonitud peade naised; Mark T. Sullivan. Puhtaks saamine; Louise Bagshave. Pikad moonid; William Shakespeare. Shakespeare armastusest; Marie Under. Õnnevarjutus; Doris Kareva. Fraktalia; Ulrike Mara. Vihmakalad

  7. Naised teaduses = Women in research / Aavo Heinlo

    Index Scriptorium Estoniae

    Heinlo, Aavo

    2006-01-01

    Naiste osa teadus- ja arendustegevuses. Naised ja mehed akadeemilise karjääri tüüpilistel astmetel Euroopa Liidus ja Eestis. Naiste karjäär ja klaaslae indeks (Glass Ceiling Index), sooline palgalõhe. Tabelid, diagrammid

  8. Naised Idamaalt ja mujalt / Aita Kivi

    Index Scriptorium Estoniae

    Kivi, Aita, 1954-

    2000-01-01

    Sisu : Kazuo Ishiguro. Mägede kahvatu terendus; Anchee Min. Punane asalea; Larissa Vassiljeva. Vene kroonitud peade naised; Mark T. Sullivan. Puhtaks saamine; Louise Bagshave. Pikad moonid; William Shakespeare. Shakespeare armastusest; Marie Under. Õnnevarjutus; Doris Kareva. Fraktalia; Ulrike Mara. Vihmakalad

  9. Quelle personne!? : naise pilk / Monika Salu

    Index Scriptorium Estoniae

    Salu, Monika

    2006-01-01

    Tallinna Ülikooli kantsler, OÜ Inotex grupp juht ja omanik, Eesti Mittetulundusühingute ja Sihtasutuste Liidu nõukogu liige, Tallinna Nõmme Gümnaasiumi hoolekogu liige, majandusteaduste doktor, kolme tütre ema, naine ja tütar Monika Salu naise rollidest

  10. Quelle personne!? : naise pilk / Monika Salu

    Index Scriptorium Estoniae

    Salu, Monika

    2006-01-01

    Tallinna Ülikooli kantsler, OÜ Inotex grupp juht ja omanik, Eesti Mittetulundusühingute ja Sihtasutuste Liidu nõukogu liige, Tallinna Nõmme Gümnaasiumi hoolekogu liige, majandusteaduste doktor, kolme tütre ema, naine ja tütar Monika Salu naise rollidest

  11. Naised vereimejate ümber / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2009-01-01

    Stephenie Meyeri "Videviku" romaani-saaga (Videvik, Noorkuu, Päikesevarjutus, Koidukuma) ja kahe esimese loo ekraniseeringud on fenomenaalselt populaarsed. Märkimisväärsed naised fenomeni loojate hulgas peale kirjanik Stephenie Meyeri on Bella osatäitja Kristen Stewart, filmide soundtrack'ide koostaja Alexandra Patsavas, sarja esimese filmi režissöör Catherine Hardwicke, saaga filmide stsenarist Melissa Rosenberg ja rock-bändi Paramore lauljatar Hayley Williams

  12. Naised vereimejate ümber / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2009-01-01

    Stephenie Meyeri "Videviku" romaani-saaga (Videvik, Noorkuu, Päikesevarjutus, Koidukuma) ja kahe esimese loo ekraniseeringud on fenomenaalselt populaarsed. Märkimisväärsed naised fenomeni loojate hulgas peale kirjanik Stephenie Meyeri on Bella osatäitja Kristen Stewart, filmide soundtrack'ide koostaja Alexandra Patsavas, sarja esimese filmi režissöör Catherine Hardwicke, saaga filmide stsenarist Melissa Rosenberg ja rock-bändi Paramore lauljatar Hayley Williams

  13. "Kalevi naised" - mis asi see oli? / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2008-01-01

    Produtsent Kristian Taska Kalev Spordis näitamiseks valminud Venezuela seebiseriaali Eesti oludele mugandatud "Kalevi naised" esimene osa (lavastaja Ingomar Vihman, osades Maria Avdjushko, Jan Uuspõld, Britta Vahur)

  14. Naised ja võim / Ignar Fjuk

    Index Scriptorium Estoniae

    Fjuk, Ignar, 1953-

    2002-01-01

    Ilmunud ka: Põhjarannik 1. veebr., lk. 2, Severnoje Poberezhje 1. veebr., lk. 2, Nädaline 2. veebr., lk. 2, Meie Maa 2. veebr., lk. 2,4, Hiiu Leht 5. veebr., lk. 2, Virumaa Teataja 5. veebr., lk. 7, Elva Postipoiss 9. veebr., lk. 4, Õpetajate Leht 8. veebr., lk. 5, Pärnu Postimees 8. veebr., lk. 2, Koit 12. veebr., lk. 6, Türi Rahvaleht 9. märts., lk. 4, Järva Teataja 9. märts lk. 2, Vali Uudised 20. märts lk. 2. Naised annavad poliitikale inimlikuma näo ja sageli ka realistlikuma sisu. Autor: Reformierakond. Parlamendisaadik

  15. Naised ja võim / Ignar Fjuk

    Index Scriptorium Estoniae

    Fjuk, Ignar, 1953-

    2002-01-01

    Ilmunud ka: Põhjarannik 1. veebr., lk. 2, Severnoje Poberezhje 1. veebr., lk. 2, Nädaline 2. veebr., lk. 2, Meie Maa 2. veebr., lk. 2,4, Hiiu Leht 5. veebr., lk. 2, Virumaa Teataja 5. veebr., lk. 7, Elva Postipoiss 9. veebr., lk. 4, Õpetajate Leht 8. veebr., lk. 5, Pärnu Postimees 8. veebr., lk. 2, Koit 12. veebr., lk. 6, Türi Rahvaleht 9. märts., lk. 4, Järva Teataja 9. märts lk. 2, Vali Uudised 20. märts lk. 2. Naised annavad poliitikale inimlikuma näo ja sageli ka realistlikuma sisu. Autor: Reformierakond. Parlamendisaadik

  16. Isa on määratud kaduvikku / Villu Päärt

    Index Scriptorium Estoniae

    Päärt, Villu, 1972-

    2008-01-01

    Briti teadlased on valmis muutma naise luuüdi spermaks ning mehi sellega elu loomise protsessist kõrvale jätma. Newcastle upon Tyneѫi ülikooli teadlased loodavad oma tehnikast abi viljatuse ravimiseks

  17. Isa on määratud kaduvikku / Villu Päärt

    Index Scriptorium Estoniae

    Päärt, Villu, 1972-

    2008-01-01

    Briti teadlased on valmis muutma naise luuüdi spermaks ning mehi sellega elu loomise protsessist kõrvale jätma. Newcastle upon Tyneѫi ülikooli teadlased loodavad oma tehnikast abi viljatuse ravimiseks

  18. Reklaamitööstus teeb naise kehast universaalse märgi / Veljo Sepp

    Index Scriptorium Estoniae

    Sepp, Veljo

    2005-01-01

    Piret Räni ühiskonnakriitiline näitus "Hello friend, are you impotent?" Eesti Kunstiakadeemia galeriis. Näha digitrükis kollaazhipannood ning fotouurimus naise keha kasutamisest ruumis ja meedias

  19. Reklaamitööstus teeb naise kehast universaalse märgi / Veljo Sepp

    Index Scriptorium Estoniae

    Sepp, Veljo

    2005-01-01

    Piret Räni ühiskonnakriitiline näitus "Hello friend, are you impotent?" Eesti Kunstiakadeemia galeriis. Näha digitrükis kollaazhipannood ning fotouurimus naise keha kasutamisest ruumis ja meedias

  20. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: "Peipsimaa kultuuripäevad" 1.-2. aug. Mustvee kultuurikeskuses, Mõisaküla kodukandipäevad" 1.-2. aug. Mõisakülas, "Kapa festival" 2. ja 3. aug. Kohilas Tohisoo pargis, "Heamuusika 2008" 1.- ja 2. aug. Võrtsjärve kaldal Ulgel, "Pillipiknik" 2. aug. Põlvamaal Süvahavval Kalmatemäel, "Marko Matvere merelaulud" 2. aug. Tartus Lodjakojas, Leigo Järvemuusika festival 2. augustil, Katalaani rahvusfestival 2. ja 3. aug. Tallinnas Raekoja platsil, "Viru Folk"8.-10. aug. Käsmus

  1. Ideaalnaistest XX sajandi alguse Eestis : XX sajandi alguse naised / Mirjam Hinrikus

    Index Scriptorium Estoniae

    Hinrikus, Mirjam, 1972-

    2005-01-01

    Naiskujutistest Noor-Eesti albumite illustratsioonides (Nikolai Triik, Erik Obermann). XX sajandi alguse eesti kunstis ja kirjanduses kõige levinumatest naisstereotüüpidest, feminiseerumisest. Näitus ja seminar "Ideaalne ja reaalne. Naised XX sajandi alguse Eestis" Kastellaanimajas

  2. "Maailma naised" on humanistlik kunstiprojekt / Claudia DeMonte ; interv. Reet Varblane

    Index Scriptorium Estoniae

    DeMonte, Claudia

    2004-01-01

    Ameerika kunstnik Claudia DeMonte, kelle kuraatoriprojekt "Maailma naised" ja isiknäitus "Retrospektiiv" on 23. I-22. II avatud Tallinna Kunstihoones. Kunstnikust, loomingust ja kuraatoriprojektist, feministlikust kunstist, naiste positsioonist USA-s, rahvusvahelisest naiste muuseumist San Franciscos, Katrin Pere tööst jm.

  3. Eesti naised võimu juures 1992-2003 / Tiina Raitviir

    Index Scriptorium Estoniae

    Raitviir, Tiina

    2003-01-01

    Eesti naiste osatähtsus seadusandliku ja täidesaatva võimu juures on väike. Tabelid: Naiste kandideerimine ja valituks osutumine valimistel 1989-2003; Naiste ja meeste kandideerimise efektiivsus valimistel 1992-2003; Mandaatide jaotus ja omandamise viis parlamendivalimistel 1992-2003; Naised valitsuse liikmena 1990-2003

  4. "Kalevi naised" - komöödia, kus nalja ei tehta / Verni Leivak

    Index Scriptorium Estoniae

    Leivak, Verni, 1966-

    2008-01-01

    Produtsent Kristian Taska filmib Jüri tehnopargis Kalev Spordis näitamiseks Venezuela seebiseriaali Eesti oludele mugandust "Kalevi naised" (lavastaja Ingomar Vihman, telerežissöör Hermes Brambat, osades Maria Avdjuško, Andrus Vaarik, Jan Uuspõld, Britta Vahur, Ken Saan jt)

  5. "Maailma naised" on humanistlik kunstiprojekt / Claudia DeMonte ; interv. Reet Varblane

    Index Scriptorium Estoniae

    DeMonte, Claudia

    2004-01-01

    Ameerika kunstnik Claudia DeMonte, kelle kuraatoriprojekt "Maailma naised" ja isiknäitus "Retrospektiiv" on 23. I-22. II avatud Tallinna Kunstihoones. Kunstnikust, loomingust ja kuraatoriprojektist, feministlikust kunstist, naiste positsioonist USA-s, rahvusvahelisest naiste muuseumist San Franciscos, Katrin Pere tööst jm.

  6. "Kalevi naised" - komöödia, kus nalja ei tehta / Verni Leivak

    Index Scriptorium Estoniae

    Leivak, Verni, 1966-

    2008-01-01

    Produtsent Kristian Taska filmib Jüri tehnopargis Kalev Spordis näitamiseks Venezuela seebiseriaali Eesti oludele mugandust "Kalevi naised" (lavastaja Ingomar Vihman, telerežissöör Hermes Brambat, osades Maria Avdjuško, Andrus Vaarik, Jan Uuspõld, Britta Vahur, Ken Saan jt)

  7. Varakeskaegse naise sõba rekonstruktsioon Siksali (Siksälä) kalmistu leiu põhjal / Ave Matsin

    Index Scriptorium Estoniae

    Matsin, Ave, 1973-

    2010-01-01

    Artiklis esitatakse varakeskaegse naise sõba rekonstruktsioon ja käsitletakse selle valmistamisprotsessi. Rekonstruktsiooni aluseks on Siksali (Siksälä) kalmistu arheoloogilistel kaevamistel avastatud villase sõba fragmendid

  8. Varakeskaegse naise sõba rekonstruktsioon Siksali (Siksälä) kalmistu leiu põhjal / Ave Matsin

    Index Scriptorium Estoniae

    Matsin, Ave, 1973-

    2010-01-01

    Artiklis esitatakse varakeskaegse naise sõba rekonstruktsioon ja käsitletakse selle valmistamisprotsessi. Rekonstruktsiooni aluseks on Siksali (Siksälä) kalmistu arheoloogilistel kaevamistel avastatud villase sõba fragmendid

  9. Naised ja see visioonivärk / Herminia Ibarra, Otilia Obodaru

    Index Scriptorium Estoniae

    Ibarra, Herminia

    2009-01-01

    Naisjuhtide suutlikkusest tuvastada uusi võimalusi ja arenguid ning välja töötada ettevõtte jaoks uusi strateegilisi suundi. Lisa: Idee praktikas; Juhtimise hädavajalikud komponendid; Mida tähendab visiooniloomise võime?. Tabel: Mees- ja naisjuhtide tulemuste võrdlus. Diagramm: Kes ütleb, et naised ei ole visionäärid?

  10. Naised ja see visioonivärk / Herminia Ibarra, Otilia Obodaru

    Index Scriptorium Estoniae

    Ibarra, Herminia

    2009-01-01

    Naisjuhtide suutlikkusest tuvastada uusi võimalusi ja arenguid ning välja töötada ettevõtte jaoks uusi strateegilisi suundi. Lisa: Idee praktikas; Juhtimise hädavajalikud komponendid; Mida tähendab visiooniloomise võime?. Tabel: Mees- ja naisjuhtide tulemuste võrdlus. Diagramm: Kes ütleb, et naised ei ole visionäärid?

  11. ???????????? ?????? ?????????????????? ???????? 1,2,3-???????? ?? 1?-?????????, ????????? ????????? ??????????????? ??????

    OpenAIRE

    2008-01-01

    ?????????? ?????????? ??????????? ? ???????? ??????? ??????? ????? ???????? 1,2,3-???????? ?? ?????????, ??? ??????????? ?? ???????????? ??????? ??????????????? ??????. ????????? ???? ???????????? ??????? ??????????????? ????(???????)?????? ?? ??????????????? ??????. ?????????? ???????? ??????? ? ?????? ???????? ????? ?????? ???????????????? ???? ?? ?????? ?????????????. ??????????? ???? ???????? ??????? ??????????????? ????(???????)?????? ? ??????????????????? ??-????????? ?????? ?????? (R1C...

  12. Naised poliitikas / Kairi Talves

    Index Scriptorium Estoniae

    Talves, Kairi, 1978-

    2003-01-01

    EL-i projekti "EL laienemine, sotsiaalne sugu ja valitsemine" (EGG) raames läbiviidud uuringust naiste aktiivsusest ja tegevusest poliitilistes organisatsioonides, suhtumisest soolise ebavõrdsuse probleemidesse ühiskonnas ning võrdõiguslikkuse edendamisse üldse. Lisa lk. 47

  13. Naised teevad meestele peo

    Index Scriptorium Estoniae

    2005-01-01

    26. aug. kogunesid Rakveres I Eesti meeste tantsupeo üldjuhid, kus kinnitati tantsurühmade registreerimise tähtaeg 15. okt. ja seminaride kalender (24. sept. rühmajuhtide seminar Rakveres, 25. sept. Tallinnas, 1. okt. Pärnus ja 2. okt. Tartus)

  14. Naised poliitikas / Kairi Talves

    Index Scriptorium Estoniae

    Talves, Kairi, 1978-

    2003-01-01

    EL-i projekti "EL laienemine, sotsiaalne sugu ja valitsemine" (EGG) raames läbiviidud uuringust naiste aktiivsusest ja tegevusest poliitilistes organisatsioonides, suhtumisest soolise ebavõrdsuse probleemidesse ühiskonnas ning võrdõiguslikkuse edendamisse üldse. Lisa lk. 47

  15. Mida naised tegelikult tahavad?

    Index Scriptorium Estoniae

    2008-01-01

    Küsimustele õnnest ja eluväärtustest vastavad Euroopa Parlamendi saadik Katrin Saks, Riigikogu asespiiker Kristiina Ojuland, ajakirjanikud Maire Aunaste ja Merle Liivak, sportlased Irina Embrich ja Meelika Limberg jt. Vt. ka art. "Maaema Kati Murutar" ja "Maaema Kauksi Ülle", lk. A43 : portr.

  16. Naised Ilvesenahkades / Agnes Nõu

    Index Scriptorium Estoniae

    Nõu, Agnes

    2006-01-01

    Jahtlaeva Santa Maria kapteni Ain Roosma soovist kogu jahtlaeva naiskond ühtsesse vormi riietada sündis tuntud Eesti spordiriiete tootjal AS-il Ilves-Extra uus tootegrupp - purjetamisrõivad. Vt. samas: Ilves-Extra valmistab nüüd purjetamisrõivaid

  17. Naised Ilvesenahkades / Agnes Nõu

    Index Scriptorium Estoniae

    Nõu, Agnes

    2006-01-01

    Jahtlaeva Santa Maria kapteni Ain Roosma soovist kogu jahtlaeva naiskond ühtsesse vormi riietada sündis tuntud Eesti spordiriiete tootjal AS-il Ilves-Extra uus tootegrupp - purjetamisrõivad. Vt. samas: Ilves-Extra valmistab nüüd purjetamisrõivaid

  18. C1-2 arthrography

    Energy Technology Data Exchange (ETDEWEB)

    Chevrot, A. [Service de Radiologie B, Hopital Cochin, 75 - Paris (France); Cermakova, E. [Service de Radiologie B, Hopital Cochin, 75 - Paris (France); Vallee, C. [Service de Radiologie B, Hopital Cochin, 75 - Paris (France); Chancelier, M.D. [Service de Radiologie B, Hopital Cochin, 75 - Paris (France); Chemla, N. [Service de Radiologie B, Hopital Cochin, 75 - Paris (France); Rousselin, B. [Service de Radiologie B, Hopital Cochin, 75 - Paris (France); Langer-Cherbit, A. [Service de Radiologie B, Hopital Cochin, 75 - Paris (France)

    1995-08-01

    One hundred patients with the following conditions were studied: cervical pain or neuralgia without radiographic changes, osteoarthritis, rheumatoid arthritis, ankylosing spondylarthritis and diverse conditions. The technique consists of lateral puncture of the posterior aspect of the C1-2 joint with a 20-gauge needle under fluoroscopic control, arthrography using 1 ml contrast medium, and a 1-ml long-acting steroid injection subsequently. The articular cavity has an anterior and a posterior recess. Sometimes the posterior recess is large. In 18% of cases the contralateral joint also opacifies. C1-2 arthrography appears to be an efficient and safe technique for the treatment of upper cervical pain due to C1-2 articular disorders. (orig.)

  19. RHM 1(2).indb

    African Journals Online (AJOL)

    mike

    Research in Hospitality Management 2012, 1(2): 85–95. Printed in South ... This paper imagines what a hotel might look like in 2050 based upon nine drivers of ..... of a quarry, will be run by geothermal energy, use sustainable materials and ...

  20. Saatuslikud prantsuse naised / Triin Thalheim

    Index Scriptorium Estoniae

    Thalheim, Triin, 1982-

    2006-01-01

    15.-21. maini on kinos Sõprus Manifesti filminädal, mis pühendatud prantsuse mängufilmidele, kus keskne karakter on femme fatale - saatuslik naine, meeste hukutaja. Sel puhul näitlejannadest : Brigitte Bardot, Jeanne Moreau, Simone Signoret ja Catherine Deneuve

  1. Naised aja meelevallas / Aita Kivi

    Index Scriptorium Estoniae

    Kivi, Aita, 1954-

    2000-01-01

    Sisu : Kärt Hellerma. Kassandra; Kärt Hellerma. Alkeemia; Viivi Luik. Seitsmes rahukevad; Mary-Rose Hayes. Ametüst; Philip Kerr. Eesav; Katie Fforde. Elluärganud roos; Vello Lattik. Kass ja hiired jagavad urgu; Brenda O'Hanlon. Uni

  2. Naise purunematu ilu / Triin Toome

    Index Scriptorium Estoniae

    Toome, Triin

    2005-01-01

    Fotograaf Laura Kallasvee ja grimmikunstnike kolmiku Grimmsisters (Helen Ehandi, Kaire Hendrikson ja Maarja Sild) ühisnäitusest "She has really long legs" ("Tal on väga pikad jalad") kohvik Moskvas, Tallinnas. Näitus koosneb tuntud naiste portreedest

  3. Naised aja meelevallas / Aita Kivi

    Index Scriptorium Estoniae

    Kivi, Aita, 1954-

    2000-01-01

    Sisu : Kärt Hellerma. Kassandra; Kärt Hellerma. Alkeemia; Viivi Luik. Seitsmes rahukevad; Mary-Rose Hayes. Ametüst; Philip Kerr. Eesav; Katie Fforde. Elluärganud roos; Vello Lattik. Kass ja hiired jagavad urgu; Brenda O'Hanlon. Uni

  4. Saatuslikud prantsuse naised / Triin Thalheim

    Index Scriptorium Estoniae

    Thalheim, Triin, 1982-

    2006-01-01

    15.-21. maini on kinos Sõprus Manifesti filminädal, mis pühendatud prantsuse mängufilmidele, kus keskne karakter on femme fatale - saatuslik naine, meeste hukutaja. Sel puhul näitlejannadest : Brigitte Bardot, Jeanne Moreau, Simone Signoret ja Catherine Deneuve

  5. Naise purunematu ilu / Triin Toome

    Index Scriptorium Estoniae

    Toome, Triin

    2005-01-01

    Fotograaf Laura Kallasvee ja grimmikunstnike kolmiku Grimmsisters (Helen Ehandi, Kaire Hendrikson ja Maarja Sild) ühisnäitusest "She has really long legs" ("Tal on väga pikad jalad") kohvik Moskvas, Tallinnas. Näitus koosneb tuntud naiste portreedest

  6. 43 CFR 2812.1-2 - Contents.

    Science.gov (United States)

    2006-10-01

    ... 43 Public Lands: Interior 2 2006-10-01 2006-10-01 false Contents. 2812.1-2 Section 2812.1-2 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT... Bay Revested Lands § 2812.1-2 Contents. (a) An individual applicant and each member of any...

  7. Spin-1/2 Maxwell Fields

    CERN Document Server

    Armour, R S

    2003-01-01

    Requiring covariance of Maxwell's equations without {\\it a priori} imposing charge invariance allows for both spin-1 and spin-1/2 transformations of the complete Maxwell field and current. The spin-1/2 case yields new transformation rules, with new invariants, for all traditional Maxwell field and source quantities. The accompanying spin-1/2 representations of the Lorentz group employ the Lorentz metric, and consequently the primary invariants of the spin-1/2 Maxwell field are also spin-1 invariants, for example, $\\Phi^2 - {\\bf A}^2$, ${\\bf E}^2 - {\\bf B}^2 + 2i {\\bf E} \\bm{\\cdot} {\\bf B} - ({\\partial}_{0}{\\Phi} + {\\bm{\

  8. AC conductivity and relaxation mechanism in (Nd1/2Li1/2)(Fe1/2V1/2)O3 ceramics

    Science.gov (United States)

    Nath, Susmita; Barik, Subrat Kumar; Choudhary, R. N. P.

    2016-05-01

    In the present study we have synthesized polycrystalline sample of (Nd1/2Li1/2)(Fe1/2V1/2)O3 ceramic by a standard high-temperature solid-state reaction technique. Studies of dielectric and electrical properties of the compound have been carried out in a wide range of temperature (RT - 400 °C) and frequency (1kHz - 1MHz) using complex impedance spectroscopic technique. The imaginary vs. real component of the complex impedance plot (Nyquist plot) of the prepared sample exhibits the existence of grain, grain boundary contributions in the complex electrical parameters and negative temperature coefficient of resistance (NTCR) type behavior like semiconductor. Details study of ac conductivity plot reveals that the material obeys universal Jonscher's power law.

  9. The stereodynamics of 1,2-dipropyldiaziridines.

    Science.gov (United States)

    Trapp, Oliver; Sahraoui, Laila; Hofstadt, Werner; Könen, Werner

    2010-02-01

    N-alkylated trans-diaziridines are an intriguing class of compounds with two stereogenic nitrogen atoms which easily interconvert. In the course of our investigations of the nature of the interconversion process via nitrogen inversion or electrocyclic ring opening ring closure, we synthesized and characterized the three constitutionally isomeric diaziridines 1,2-di-n-propyldiaziridine 1, 1-isopropyl-2-n-propyldiaziridine 2, and 1,2-diisopropyldiaziridine 3 to study the influence of the substituents on the interconversion barriers. Enantiomer separation was achieved by enantioselective gas chromatography on the chiral stationary phase Chirasil-beta-Dex with high separation factors alpha (1-isopropyl-2-n-propyldiaziridine: 1.18; 1, 2-diisopropyldiaziridine: 1.24; 100 degrees C 50 kPa He) for the isopropyl substituted diaziridines. These compounds showed pronounced plateau formation between 100 and 150 degrees C, and peak coalescence at elevated temperatures. The enantiomerization barriers DeltaG(double dagger) and activation parameters DeltaH(double dagger) and DeltaS(double dagger) were determined by enantioselective dynamic gas chromatography (DGC) and direct evaluation of the elution profiles using the unified equation implemented in the software DCXplorer. Interestingly, 1-isopropyl-2-n-propyldiaziridine and 1,2-diisopropyldiaziridine exhibit similar high interconversion barriers DeltaG(double dagger) (100 degrees C) of 128.3 +/- 0.4 kJ mol(-1) and 129.8 +/- 0.4 kJ mol(-1), respectively, which indicates that two sterically demanding substituents do not substantially increase the barrier as expected for a distinct nitrogen inversion process.

  10. Spin 1/2 and Invariant Coefficients

    OpenAIRE

    Shurtleff, Richard

    2004-01-01

    Massive spin 1/2 particles require 2-spinors for rotations, 4-spinors for rotations and boosts with parity. Including translations requires 8-spinors. Adapting 4-spinor field theory to 8-spinor fields with translation symmetry is discussed here. It is shown that four of these spin components act like conventional 4-spinors, satisfying the conventional free-particle Dirac equation. The remaining four components have unconventional coordinate dependence due to translation symmetry. One finds th...

  11. Taming the 1.2 m Telescope

    Science.gov (United States)

    Griffin, S.; Edwards, M.; Greenwald, D.; Kono, D.; Liang, D.; Lohnes, K.; Wright, V.; Spillar, E.

    2013-09-01

    Achievable residual jitter on the 1.2 m telescope at MSSS shown in Figure 1 has historically been limited to 10-20 arc-sec. peak in moderate wind conditions due to the combination of the dynamics associated with the twin telescopes on the common declination axis shaft, and the related control system behavior. Figure 1 1.2 m Telescope The lightly damped, low frequency fundamental vibration mode shape of the telescopes rotating out of phase on the common declination axis shaft severely degraded the performance of the prior controllers. This vibration mode is easily excited by external forces such as wind loading and internal torque commands from the mount control system. The relatively poor historic performance was due to a combination of the low error rejection of external disturbances, and the controller exciting the mode. A radical new approach has been implemented that has resulted in a decrease of jitter to less than 1 arcsec under most conditions. The new approach includes minor hardware modifications to provide active damping with accelerometers as feedback sensors. This architecture has allowed a bandwidth increase of almost an order of magnitude and eliminated the large amplitude motions at the mode natural frequency, resulting in much improved pointing and jitter performance. A representative comparison of historical versus new architecture performance is shown in Figure 2 for the declination axis.

  12. The 1 , 2 , 3-Conjecture And 1 , 2-Conjecture For Sparse Graphs

    Directory of Open Access Journals (Sweden)

    Cranston Daniel W.

    2014-11-01

    Full Text Available The 1, 2, 3-Conjecture states that the edges of a graph without isolated edges can be labeled from {1, 2, 3} so that the sums of labels at adjacent vertices are distinct. The 1, 2-Conjecture states that if vertices also receive labels and the vertex label is added to the sum of its incident edge labels, then adjacent vertices can be distinguished using only {1, 2}. We show that various configurations cannot occur in minimal counterexamples to these conjectures. Discharging then confirms the conjectures for graphs with maximum average degree less than 8/3. The conjectures are already confirmed for larger families, but the structure theorems and reducibility results are of independent interest.

  13. On a directed variation of the 1-2-3 and 1-2 Conjectures

    DEFF Research Database (Denmark)

    Barme, Emma; Bensmail, Julien; Przybyło, Jakub;

    2016-01-01

    In this paper, we consider the following question, which stands as a directed analogue of the well-known 1-2-3 Conjecture: Given any digraph D with no arc uv verifying d+(u) = d¯(v) = 1, is it possible to weight the arcs of D with weights among ⟨1; 2; 3⟩ so that, for every arc uv of D, the sum of...

  14. PRIze{sup TM} 1.2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-10-01

    PRIze{sup TM} 1.2 is a computer program that evaluates the improved oil recovery (IOR) potential of petroleum reservoirs including the use of horizontal wells. It was created in 1992 and has since been used in over 800 reservoir evaluations. The tool provides information on the feasibility of IOR processes based on reservoir parameters. PRIze{sup TM} makes predictions for chemical, gas injection and thermal IOR processes based on both vertical and horizontal wells. The program provides a uniform data entry screen that allows the user to input 42 average values of geological parameters, fluid properties and oil production mechanism information into a data file. The data can be used to provide a production forecast, and enable the user to establish, to a first order approximation, the economic viability of a given process.

  15. 1,2-Bis(N′-benzoylthioureidobenzene

    Directory of Open Access Journals (Sweden)

    Aliou Hamady Barry

    2008-05-01

    Full Text Available The title compound, C22H18N4O2S2, was characterized by 1H and 13C NMR, solid-state IR spectroscopy and X-ray crystallographic techniques. The crystal structure determination reveals that the twisting modes of the two side arms are different [C—N—C—O and C—N—C—N torsion angles = −1.2 (3 and 1.1 (3°, respectively, in one arm and 24.1 (3 and −5.1 (3°, respectively, in the other]. The crystal structure involves N—H...O and N—H...S hydrogen bonds.

  16. 1,2-hydroxypyridonates as contrast agents for magnetic resonance imaging: TREN-1,2-HOPO.

    Science.gov (United States)

    Jocher, Christoph J; Moore, Evan G; Xu, Jide; Avedano, Stefano; Botta, Mauro; Aime, Silvio; Raymond, Kenneth N

    2007-10-29

    1,2-Hydroxypyridinones (1,2-HOPO) form very stable lanthanide complexes that may be useful as contrast agents for magnetic resonance imaging (MRI). X-ray diffraction of single crystals established that the solid-state structures of the Eu(III) and the previously reported [Inorg. Chem. 2004, 43, 5452] Gd(III) complex are identical. The recently discovered sensitizing properties of 1,2-HOPO chelates for Eu(III) luminescence [J. Am. Chem. Soc. 2006, 128, 10 067] allow for direct measurement of the number of water molecules coordinated to the metal center. Fluorescence measurements of the Eu(III) complex corroborate that, in solution, two water molecules coordinate the lanthanide (q = 2) as proposed from the analysis of NMRD profiles. In addition, fluorescence measurements have verified the anion binding interactions of lanthanide TREN-1,2-HOPO complexes in solution, studied by relaxivity, revealing only very weak oxalate binding (KA = 82.7 +/- 6.5 M-1). Solution thermodynamic studies of the metal complex and free ligand have been carried out using potentiometry, spectrophotometry, and fluorescence spectroscopy. The metal ion selectivity of TREN-1,2-HOPO supports the feasibility of using 1,2-HOPO ligands for selective lanthanide binding [pGd = 19.3 (2), pZn = 15.2 (2), pCa = 8.8 (3)].

  17. 3-(4-Amino-1,2,5-oxadiazol-3-yl-4-(4-nitro-1,2,5-oxadiazol-3-yl-1,2,5-oxadiazole

    Directory of Open Access Journals (Sweden)

    Philip Pagoria

    2014-05-01

    Full Text Available The title compound 3-(4-amino-1,2,5-oxadiazol-3-yl-4-(4-nitro-1,2,5-oxadiazol-3-yl-1,2,5-oxadiazole (ANFF-1 was synthesized by: (1 by reaction of 3,4-bis(4-nitro-1,2,5-oxadiazol-3-yl-1,2,5-oxadiazole (BNFF-1 with gaseous ammonia in toluene and (2 by partial oxidation of 3,4-bis(4-amino-1,2,5-oxadiazol-3-yl-1,2,5-oxadiazole (BAFF-1 with 35% H2O2 in concentrated H2SO4.

  18. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: "Koolilõpupidu" 23. mail Tallinnas Rock Cafés, Valeri Leontjev 26. mail Tallinna Linnahallis, Malang Cissokho 27. mail Tartus Athena keskuses, idamaine pidu "Bazaar" 24. mail Tallinnas teatris NO99, ansamblid Röövel Ööbik, Honey Power ja Lack of Eoins 23. mail ja muusikafestival "Regiöö 2008" 24. mail Tartus Genialistide klubis, Jäneda aia- ja lillepäevad koos simmanitega (esinevad ansamblid Hellad Velled ja PS Troika), Viljandimaa laulupüha ja tantsupidu 24. mail, rahvakultuuripidu Kirde Killad 31. maist 1. juunini Mäetaguse mõisas

  19. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: Volbriöö peod 30. apr. Tallinnas, Tõrvas, Tartus ja Rakveres, ansambli Köök, ETV tütarlastekoori ja G. Otsa nim. Tallinna Muusikakooli bigbändi kontsert 29. apr. Viljandis Pärimusmuusika Aidas, löökpillimuusika 25. apr. Viljandis Pärimusmuusika Aidas, ürituses "Cabaret Derrida" 25. apr. Tallinnas Kultuurikatlas ja 30. apr. Tartus Sadamateatris, Anne Veski soolokontsert 1. mail Tallinna Linnahallis, kontsert "Anarhy in the Est 2008" 1. mail Tartus, Tshellokvartett C-JAM 26. apr. Vihterpalu mõisas, öölaulupidu 28. apr. Tartu kevadpäevade raames Kassitoome nõlvadel, No Smoking Orchestra 26. apr. Tallinnas Club Von Überblingenis, löökpillimängijate showgrupp Trash.dk 25. apr. Pärnu kontserdimajas ja 26. apr. Vanemuise kontserdimajas

  20. Hella hingega karmid naised / Krista Kaer

    Index Scriptorium Estoniae

    Kaer, Krista

    1996-01-01

    Tänapäeva kriminaalromaani inglise ja ameerika autoritest (Dame Phyllis Dorothy James, Joan Smith, Lynda La Plante (inglise); Sara Paretsky, Sue Grafton, Patricia Cornwell (ameerika) ja nende poolt loodud naisdetektiivi kujudest

  1. Saatuslikud naised / Tristan Priimägi

    Index Scriptorium Estoniae

    Priimägi, Tristan, 1976-

    2006-01-01

    15.-21. maini on kinos Sõprus Manifesti filminädal, mis pühendatud prantsuse mängufilmidele, kus keskne karakter on femme fatale - saatuslik naine, meeste hukutaja. Ajalooline lühiülevaade selle naisetüübi kujutamisest kinolinal

  2. Kolme naise lood Kandles / Elina Kononenko

    Index Scriptorium Estoniae

    Kononenko, Elina, 1981-

    2005-01-01

    30. nov. saab Võru kultuurimajas Kannel näha saksa päritolu Ameerika helilooja Kurt Weilli loomingu põhjal valminud muusikalist etendust "Jenny, Polly, Nanna". Laulab Triin Ella, jutustaja rollis on Toomas Tross

  3. Sinjoore Ernesto ja saatuslikud naised / Sulev Vedler

    Index Scriptorium Estoniae

    Vedler, Sulev, 1970-

    2004-01-01

    Tallinna Linnakohtus algab kohtuprotsess ärimees Ernesto Preatoni üle, keda süüdistatakse 50 miljoni kroonises pettuses. Preatoni äridest Itaalias ja Eestis. Tabel: Pro Kapitali suuremad aktsionärid

  4. Hella hingega karmid naised / Krista Kaer

    Index Scriptorium Estoniae

    Kaer, Krista

    1996-01-01

    Tänapäeva kriminaalromaani inglise ja ameerika autoritest (Dame Phyllis Dorothy James, Joan Smith, Lynda La Plante (inglise); Sara Paretsky, Sue Grafton, Patricia Cornwell (ameerika) ja nende poolt loodud naisdetektiivi kujudest

  5. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: Rahvusooper Estonia koostöös Nukuteatri ning Teatri- ja Muusikamuuseumiga kutsub lapsi kolmepäevastesse laagritesse kahe nädala jooksul ajavahemikus 9.-20. juunini (vt. www. junior.opera.ee), ansambel "Skriimsilm" 16. mail Tallinnas Rock Cafes, Eesti Kontserdi hooaja lõpp-kontserdid (esineb Helsingi Filharmoonia orkester) 16. mail Jõhvi kontserdimajas ja 17. mail Pärnu kontserdimajas, Puccini gala 16. mail Tallinnas Vene teatris, Backstreet Boys 19. mail Tallinnas Saku Suurhallis, "Küünikontsert: Liisi Koikson" 17. mail Kuusalu vallas Kolgaküla küünis, Busta Rhymes 18. mail Tallinnas Club von Überblingenis

  6. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: võrokeelse laulu- ja rahvapeo peakontsert "Uma Pido" 31. mail Kubija laululaval, "Türi kevadfest" 30. maist 1. juunini Türil, "Paljassaare RockFest" 31. mail Tallinnas Paljassaare põik 14 sisehoovis, Raplamaa laulu- ja tantsupidu "Mis maa see on" 31. mail ja ansamblite Metsatöll ja Vägilased kontsert 1. juunil Mahtra sõjaväljal, "Vanalinnapäevad" Tallinnas 2.-8. juunil, Lastekaitsepäeva heategevuskontsert 1. juunil Tartus, "Nõmme Kevad" 30. mail Tallinnas Nõmmel Lunastaja kirikus (esinevad Tallinna Muusikakeskkooli kammerkoor ja solistid), Bob Dylan 4. juunil Saku Suurhallis, Punklaulupeo warmup 30. mail Rock Cafes, rocklaulja Sebastian Bach 6. juunil Pirita kloostris

  7. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: "Flamenkofantaasiad" 2. mail Jõhvi kontserdimajas, "Frank Sinatra gala" 6. mail Vanemuise kontserdisaalis, 7. mail Pärnu kontserdimajas ja 9. mail Tallinna Linnahallis, Brides in Bloom 2. mail Tallinnas Rock Cafes, Demis Roussos 6. mail Saku Suurhallis, Vaiko Epilk ja Eliit heliplaadi "3: Kosmoseodüsseia" esitluskontsert 8. mail Rock Cafés, Chalice'i ja Jürmo Eespere trio kontserdist 6. mail Estonia Talveaias, Ultima Thule, Evergreen 86, Groundhog Day rokk-kontserdil 2. mail Tartus Vabaduse puiesteel

  8. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: "Koolilõpupidu" 23. mail Tallinnas Rock Cafés, Valeri Leontjev 26. mail Tallinna Linnahallis, Malang Cissokho 27. mail Tartus Athena keskuses, idamaine pidu "Bazaar" 24. mail Tallinnas teatris NO99, ansamblid Röövel Ööbik, Honey Power ja Lack of Eoins 23. mail ja muusikafestival "Regiöö 2008" 24. mail Tartus Genialistide klubis, Jäneda aia- ja lillepäevad koos simmanitega (esinevad ansamblid Hellad Velled ja PS Troika), Viljandimaa laulupüha ja tantsupidu 24. mail, rahvakultuuripidu Kirde Killad 31. maist 1. juunini Mäetaguse mõisas

  9. Saatuslikud naised Sõpruse ekraanil / Rein Pakk

    Index Scriptorium Estoniae

    Pakk, Rein, 1968-

    2006-01-01

    15.-21. maini on kinos Sõprus Manifesti filminädal "Femme fatale", mis pühendatud prantsuse mängufilmidele 1960.-1970. aastate tipprežissööridelt, kus keskne karakter on saatuslik naine. Lisatud festivali mängukava

  10. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: Rebecca "Inglite pisarad" 10. apr. Tallinnas Toompeal Nelipühi kirikus, "Puhkpilliorkester Tartu 60" 6. apr. Vanemuise kontserdimajas, Singer-Vinger 4. apr. Tallinnas Rock Cafés, "Kolumbus Kris 21" 11. apr. Rock Cafés, "Rock & Roll City" 5. apr. Rock Cafés, Voiceboys 4. apr. Vanemuise kontserdimajas, 5. apr. Jõhvi kontserdimajas ja 6. apr. Estonia kontserdisaalis, "The Musigue Bazaar" 4. apr. Tartus baaris Tige Tikker, Clubarena sünnipäev 4. apr. Tallinnas Mustpeade majas (vt. www.clubarena.com)

  11. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Kontsertidest: Pirjo Levandi "Laulud minu elus" 9. veebr. Nõmme Kultuurikeskuses, Eesti gospelmuusika auhinnad 9. veebr. Salme kultuurikeskuses, ansambel Leningrad 9. veebr. Club von Überblingenis, Delunas Blues Band 14. veebr. restoranis Clazz, ameerika bändid Korn, Flyleaf ja rootsi bänd Deathstars 10. veebr. Saku Suurhallis, Dima Bilan 15. veebr. Saku Suurhallis, Heikki Sarmanto dzhässooper "Manon" 13. veebr. Jõhvi Kontserdimajas, 145. veebr. Estonia kontserdissaalis ja 16. veebr. Pärnu Kontserdimajas

  12. Saatuslikud naised Sõpruse ekraanil / Rein Pakk

    Index Scriptorium Estoniae

    Pakk, Rein, 1968-

    2006-01-01

    15.-21. maini on kinos Sõprus Manifesti filminädal "Femme fatale", mis pühendatud prantsuse mängufilmidele 1960.-1970. aastate tipprežissööridelt, kus keskne karakter on saatuslik naine. Lisatud festivali mängukava

  13. Naised parandavad maailma / interv. Meelike Saarna

    Index Scriptorium Estoniae

    2000-01-01

    Naisorganisatsioonidest vestlevad Hille Karm, Kristina Märtin, Kadi Tarand, Tiina Tammer, Silva Tomingas, Tiina Tegelmann. Eesti Ettevõtlike Naiste Assotsiatsioon (EENA). Zonta International. Palamuse naisselts. Isamaaliidu naiskogu. Naisajakirjanike klubi. Korporatisoon Fliae Patriae

  14. Naised poliitikas ja parem maailm / Iivi Masso

    Index Scriptorium Estoniae

    Masso, Iivi, 1967-

    2007-01-01

    Läänemaailma poliitika supernaistest: Suurbritannia endine peaminister Margaret Thatcher, USA välisminister Condoleezza Rice ja Saksamaa kantsler Angela Merkel. Põhjamaade naiste osalemisest poliitikas, näiteid Rootsi ja Soome poliitikast: Nyamko Sabuni, Tarja Halonen

  15. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: "Flamenkofantaasiad" 2. mail Jõhvi kontserdimajas, "Frank Sinatra gala" 6. mail Vanemuise kontserdisaalis, 7. mail Pärnu kontserdimajas ja 9. mail Tallinna Linnahallis, Brides in Bloom 2. mail Tallinnas Rock Cafes, Demis Roussos 6. mail Saku Suurhallis, Vaiko Epilk ja Eliit heliplaadi "3: Kosmoseodüsseia" esitluskontsert 8. mail Rock Cafés, Chalice'i ja Jürmo Eespere trio kontserdist 6. mail Estonia Talveaias, Ultima Thule, Evergreen 86, Groundhog Day rokk-kontserdil 2. mail Tartus Vabaduse puiesteel

  16. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: ansambli Metsatöll heliplaadi "Iivakivi" esitluskontsertidest 7. märtsil Tallinnas klubis Hollywood ja 8. märtsil Tartu Sadamateatris, Ultima Thule sünnipäevakontserdist 7. märtsil Tallinnas Rock Cafés, Jäääär 8. märtsil Rock Cafés, Koit Toome ja Uku Suviste 12. märtsil Pärnu kontserdimajas, Kuninglik kvintett 8. märtsil Kiviõli rahvamajas, "Naerata nüüd jälle sa" (Maarja-Liis Ilus, Alen Veziko, Margus Vaher, Andre Hein, Raimondo Laikre) 9. märtsil Vanemuise kontserdimajas, "Kaunimad... su elus" (ansambel Kaunimate Aastate Vennaskond) 7. märtsil Jõhvi kontserdimajas, 8. märtsil Vanemuise kontserdimajas ja 9. märtsil Pärnu kontserdimajas, Tarmo ja Toomas Urb 8. märtsil Viljandi kultuurimajas, Koit Toome 7. märtsil Tartu Jaani kirikus, Noorkuu naistepäevakontsert 8. märtsil Rakvere spordihallis, Eesti heliloojate armastuslaulud ETV tütarlastekoori esituses 8. märtsil Jõhvi kontserdimajas, Brides in Bloom + DJ Kahurid 8. märtsil Tallinnas klubis Woodstock, Richard Clayderman 11. märtsil Estonia kontserdisaalis

  17. Sõda, viin, naised ja surm / Vaapo Vaher

    Index Scriptorium Estoniae

    Vaher, Vaapo, 1945-

    2005-01-01

    Tutvustus: Gelassimov, Andrei. Janu / vene k. tlk. Jaan Ross. Tallinn : Kultuurileht, 2005. (Loomingu Raamatukogu) ; Austen, Jane. Mõistus ja tunded / inglise k. tlk. Karin Suursalu. Tallinn : Tänapäev, 2005 ; Kiik, Heino. Ole usin : 1948-1954. Tartu : Ilmamaa, 2005 ; Palm, August. Villem Reiman : [1861-1917]. 2., täiend. tr. Tartu : Ilmamaa, 2004

  18. Kliiniline kapitalism ja naise neim / Vaapo Vaher

    Index Scriptorium Estoniae

    Vaher, Vaapo, 1945-

    2011-01-01

    Tutvustus: Kõiv, Salme. Reet Tammiku. Tallinn : Eesti Raamat, 2011 ; Kalda, Katrin. Eesti romaan / tõlkinud Anti Saar. Tallinn : Varrak, 2011 ; Zola, Émile. Saak / tõlkinud Kaja Riesen. Tallinn : Eesti Raamat, 2011

  19. Naise keha pole kaup / Marianne Mikko

    Index Scriptorium Estoniae

    Mikko, Marianne, 1961-

    2006-01-01

    Postitutsiooniprobleemidest Eestis ning võimalikest lahendustest selle vähendamiseks. Ilmunud ka Kuulutaja 3. veeb. 2006, lk. 4 ; Lääne Elu 7. veeb. 2006, lk. 2 ; Meie Maa 7. veeb. 2006, lk. 2 ; Virumaa Nädalaleht 3. veeb. 2006, lk. 4 ; Vooremaa 4. veeb. 2006, lk. 2 ; Hiiu Leht 10. veeb. 2006, lk. 2 ; Harjumaa 7. veeb. 2006, lk. 2 ; Lõunaleht 9. veeb. 2006, lk. 2 ; Pärnu Postimees 25. veeb. 2006, lk. 19

  20. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: Koit Toome laulab Jaak Joala lauldud laule 25. juulist 31. juulini Eesti kirikutes, "Smilers ETV Live" (kaastegev Üle-Eestilise Noorte Sümfooniaorkestri oktett) 25. juulil Elva laululaval, 27. juulil Keila laululaval ja 31. juulil Pärnu kõlakojas, rahvalauliku Virve Kösteri suvetuur "Mere pidu!" 30. juulil Sõru rannas, 31. juulil Haapsalu piiskopilinnuses, 1. aug. Pärnu vallikäärus ja 2. aug. Tartu Antoniuse õuel, kontsert "Muusa puudutus" 1. aug. Pärnus Ammende villas, festival "Viljandi Folk" 25.-27. juulini, "Airport Jam" 1. ja 2. aug. Kiltsi lennuväljal, "Klaaspärlimäng" Tartu Jaani kirikus 26. juulil, Mustpeade majas Tallinnas 27. juulil, "James Bondi gala" 1. aug. Põltsamaa lossi hoovis, "Ooper Tallinna raekojas" 25. juulil, Saaremaa ooperipäevad 25. juulil Kuressaare lossi ooperimajas, "Hoffmani lood" 26. juulil Kuressaare lossi ooperimajas, "Hullumisstseene kvaliteetooperitest" 27. juulil ja 3. aug. Pärnu vanalinna õues

  1. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: Rebecca "Inglite pisarad" 10. apr. Tallinnas Toompeal Nelipühi kirikus, "Puhkpilliorkester Tartu 60" 6. apr. Vanemuise kontserdimajas, Singer-Vinger 4. apr. Tallinnas Rock Cafés, "Kolumbus Kris 21" 11. apr. Rock Cafés, "Rock & Roll City" 5. apr. Rock Cafés, Voiceboys 4. apr. Vanemuise kontserdimajas, 5. apr. Jõhvi kontserdimajas ja 6. apr. Estonia kontserdisaalis, "The Musigue Bazaar" 4. apr. Tartus baaris Tige Tikker, Clubarena sünnipäev 4. apr. Tallinnas Mustpeade majas (vt. www.clubarena.com)

  2. Naised, keda mehed rajal kardavad / Helen Teesalu

    Index Scriptorium Estoniae

    Teesalu, Helen

    2008-01-01

    Vt. ka Postimees : na russkom jazõke : Avto i Tehnika 26. sept., lk. 4. CCG ehk Car Club Girls on Eesti ainuke ametlik naiste autoklubi, mille liikmed teevad võidusõidu- ja kiirendusrajal silmad ette nii mõnelegi mehele

  3. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: Rahvusooper Estonia koostöös Nukuteatri ning Teatri- ja Muusikamuuseumiga kutsub lapsi kolmepäevastesse laagritesse kahe nädala jooksul ajavahemikus 9.-20. juunini (vt. www. junior.opera.ee), ansambel "Skriimsilm" 16. mail Tallinnas Rock Cafes, Eesti Kontserdi hooaja lõpp-kontserdid (esineb Helsingi Filharmoonia orkester) 16. mail Jõhvi kontserdimajas ja 17. mail Pärnu kontserdimajas, Puccini gala 16. mail Tallinnas Vene teatris, Backstreet Boys 19. mail Tallinnas Saku Suurhallis, "Küünikontsert: Liisi Koikson" 17. mail Kuusalu vallas Kolgaküla küünis, Busta Rhymes 18. mail Tallinnas Club von Überblingenis

  4. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: võrokeelse laulu- ja rahvapeo peakontsert "Uma Pido" 31. mail Kubija laululaval, "Türi kevadfest" 30. maist 1. juunini Türil, "Paljassaare RockFest" 31. mail Tallinnas Paljassaare põik 14 sisehoovis, Raplamaa laulu- ja tantsupidu "Mis maa see on" 31. mail ja ansamblite Metsatöll ja Vägilased kontsert 1. juunil Mahtra sõjaväljal, "Vanalinnapäevad" Tallinnas 2.-8. juunil, Lastekaitsepäeva heategevuskontsert 1. juunil Tartus, "Nõmme Kevad" 30. mail Tallinnas Nõmmel Lunastaja kirikus (esinevad Tallinna Muusikakeskkooli kammerkoor ja solistid), Bob Dylan 4. juunil Saku Suurhallis, Punklaulupeo warmup 30. mail Rock Cafes, rocklaulja Sebastian Bach 6. juunil Pirita kloostris

  5. Juudi naise pilt purustas hinnarekordi / Eda Post

    Index Scriptorium Estoniae

    Post, Eda, 1983-

    2006-01-01

    Miljardär Roland Lauderile kuuluv New Yorgi saksa ja austria kunsti muuseum Neue Galerie ostis 135 miljoni dollari eest austria kunstniku Gustav Klimti õlimaali "Kuldne Adele" Adele Bloch-Bauerist. Lähemalt maali valmimisest ja saatusest. Bloch-Baueri kunstikogu saatusest

  6. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: Jääboileri kontsert 22. veebr. Tartus Genialistide klubis, "EV 90: Palju õnne, Eesti!" (esinevad Kuressaare lauljad ja rahvatantsijad, tantsuks ansambel Anna Minna) 23. veebr. Kuressaare kultuurikeskuses, Metsatöllu sünnipäev 23. veebr. Tallinnas klubis Woodstock, Etnosari: Vägilased 27. veebr. Estonia Talveaias, Zemfira 23. veebr. Eesti Näituste messikeskuses, Winterfest 22. veebr. Tallinnas Kultuurikatlas, Marju Länik 27. veebr. Türi kultuurimajas, Chris Rea 23. veebr. Tallinnas Saku Suurhallis

  7. Kunstnikud rehabiliteerivad vana naise / Johannes Saar

    Index Scriptorium Estoniae

    Saar, Johannes, 1965-

    2005-01-01

    Rahvusvaheline vananemiseteemaline kunstinäitus "Homo grandis natu" Tallinna Kunstihoones. Kuraator Reet Varblane. Osalejate loetelu. 21. aprillil avatakse Katarzyna Kozyra videoinstallatsioon "Naiste saun". Näitusega haakuvad seminar ja loengusari

  8. Naised, kes teevad suurt raha / Katrin Kapara

    Index Scriptorium Estoniae

    Kapara, Katrin

    2008-01-01

    Maailma rikkaimate inimeste edetabelit koostava ajakirja Forbes nimestikus oli tänavu 99 naist. Liliane Bettencourt - kosmeetikaimpeeriumi LþOreal pärija, Zhang Xin - firma SOHO China omanik, Cristina Green - jaekaubanduskettide omanik, Jelena Baturina - Vene ärinaine, Meg Whitman - eBay käivitaja, Oprah Winfrey - Ameerika telesaatejuht

  9. Sinjoore Ernesto ja saatuslikud naised / Sulev Vedler

    Index Scriptorium Estoniae

    Vedler, Sulev, 1970-

    2004-01-01

    Tallinna Linnakohtus algab kohtuprotsess ärimees Ernesto Preatoni üle, keda süüdistatakse 50 miljoni kroonises pettuses. Preatoni äridest Itaalias ja Eestis. Tabel: Pro Kapitali suuremad aktsionärid

  10. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: Jääboileri kontsert 22. veebr. Tartus Genialistide klubis, "EV 90: Palju õnne, Eesti!" (esinevad Kuressaare lauljad ja rahvatantsijad, tantsuks ansambel Anna Minna) 23. veebr. Kuressaare kultuurikeskuses, Metsatöllu sünnipäev 23. veebr. Tallinnas klubis Woodstock, Etnosari: Vägilased 27. veebr. Estonia Talveaias, Zemfira 23. veebr. Eesti Näituste messikeskuses, Winterfest 22. veebr. Tallinnas Kultuurikatlas, Marju Länik 27. veebr. Türi kultuurimajas, Chris Rea 23. veebr. Tallinnas Saku Suurhallis

  11. Kultuuritehas : masinad, naised, muusika / Rednar Annus

    Index Scriptorium Estoniae

    Annus, Rednar, 1970-

    2006-01-01

    Kultuuritehase festival 18.-27.augustini 2006 a. Kultuuritehases Polymer. Lähemalt Erik Alalooga tööst "Väga mõnusad masinad", Inna Joosti töödest "Orkaan Katrina" ja "Maakera", Taavi Piibemanni fotoseeriast "Morbiid lendas üle", Kadri Metstaki, Edith Karlsoni, Marje Mee ja Delina Reissi kipsskulptuurist "Linda", Raul Viitungi fotonäitusest "Aborigeenid", Maiu Kurvitsa fotoseeriast "Kollanemees - kangelane, kes võidab naeratusega maailma", Ed Labetski ja Agu Visaku installatsioonist "Korrektne?"

  12. Naise keha pole kaup / Marianne Mikko

    Index Scriptorium Estoniae

    Mikko, Marianne, 1961-

    2006-01-01

    Postitutsiooniprobleemidest Eestis ning võimalikest lahendustest selle vähendamiseks. Ilmunud ka Kuulutaja 3. veeb. 2006, lk. 4 ; Lääne Elu 7. veeb. 2006, lk. 2 ; Meie Maa 7. veeb. 2006, lk. 2 ; Virumaa Nädalaleht 3. veeb. 2006, lk. 4 ; Vooremaa 4. veeb. 2006, lk. 2 ; Hiiu Leht 10. veeb. 2006, lk. 2 ; Harjumaa 7. veeb. 2006, lk. 2 ; Lõunaleht 9. veeb. 2006, lk. 2 ; Pärnu Postimees 25. veeb. 2006, lk. 19

  13. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: "Levimuusikapäevad" 24.-27. apr. Tartus Genialistide klubis Lutsu teatrimajas, "Peda Folk" 22. apr. Tallinnas Kultuurikatlas (Põhja pst 27a), etnosari "Sotto Voce" 23. apr. Estonia Talveaias, kontsert "Sotspop 2008" 26. apr. Tallinna linnahallis, Jüripäeva kontsert 23. apr. Tallinna Jaani kirikus, Bonzo ja Tõun "Soojad laulud" 18. apr. Pirita Vaba Aja Keskuses, The Suni uue plaadi esitlus 19. apr. Tallinnas Rock Cafes

  14. Kultuuritehas : masinad, naised, muusika / Rednar Annus

    Index Scriptorium Estoniae

    Annus, Rednar, 1970-

    2006-01-01

    Kultuuritehase festival 18.-27.augustini 2006 a. Kultuuritehases Polymer. Lähemalt Erik Alalooga tööst "Väga mõnusad masinad", Inna Joosti töödest "Orkaan Katrina" ja "Maakera", Taavi Piibemanni fotoseeriast "Morbiid lendas üle", Kadri Metstaki, Edith Karlsoni, Marje Mee ja Delina Reissi kipsskulptuurist "Linda", Raul Viitungi fotonäitusest "Aborigeenid", Maiu Kurvitsa fotoseeriast "Kollanemees - kangelane, kes võidab naeratusega maailma", Ed Labetski ja Agu Visaku installatsioonist "Korrektne?"

  15. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: Volbriöö peod 30. apr. Tallinnas, Tõrvas, Tartus ja Rakveres, ansambli Köök, ETV tütarlastekoori ja G. Otsa nim. Tallinna Muusikakooli bigbändi kontsert 29. apr. Viljandis Pärimusmuusika Aidas, löökpillimuusika 25. apr. Viljandis Pärimusmuusika Aidas, ürituses "Cabaret Derrida" 25. apr. Tallinnas Kultuurikatlas ja 30. apr. Tartus Sadamateatris, Anne Veski soolokontsert 1. mail Tallinna Linnahallis, kontsert "Anarhy in the Est 2008" 1. mail Tartus, Tshellokvartett C-JAM 26. apr. Vihterpalu mõisas, öölaulupidu 28. apr. Tartu kevadpäevade raames Kassitoome nõlvadel, No Smoking Orchestra 26. apr. Tallinnas Club Von Überblingenis, löökpillimängijate showgrupp Trash.dk 25. apr. Pärnu kontserdimajas ja 26. apr. Vanemuise kontserdimajas

  16. Kliiniline kapitalism ja naise neim / Vaapo Vaher

    Index Scriptorium Estoniae

    Vaher, Vaapo, 1945-

    2011-01-01

    Tutvustus: Kõiv, Salme. Reet Tammiku. Tallinn : Eesti Raamat, 2011 ; Kalda, Katrin. Eesti romaan / tõlkinud Anti Saar. Tallinn : Varrak, 2011 ; Zola, Émile. Saak / tõlkinud Kaja Riesen. Tallinn : Eesti Raamat, 2011

  17. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: rockansamblite Sõpruse Puiestee, Dirty Diana ja Shotgun Suicide peost 15. veebr. Rock Cafés, folklooripeost Pärnus Rääma Nooruse majas, klubi Woodstocki 5. sünnipäeva tähistamisest 15. ja 16. veebr., Ultima Thule kontserdist 15. veebr. Tartu Rockiklubis, festivalist "Eesti teater Estonias"16.-23. veebr.Rahvusooperis Estonia, kontsertidest "Küünlavalgel" 19.-21. veebr. Tallinna Matkamajas, prantsuse duo 2G Kevadjazzil 2008 15. veebr. Tartus Athena keskuses, Raadio Elmari juubelipeost 22. veebr. Pärnu kuursaalis, rootsi bändi Soilwork ja Path Of No Return kontserdist 20. veebr. Tallinnas Rock Cafés

  18. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: "TRE Supershow" 8. veebr. Tartus A Le Coqi Spordimajas, Tõnis Mägi ja Co 6. veebr. Häädemeeste Miikaeli kirikus, Pille Lille Muusikute Toetusfondi Galakontsert 6. veebr. Estonia kontserdisaalis, muusikal "Lumivalgeke ja 7 pöialpoissi" 3. j 10. veebr. Rahvusooperis Estonia, kontsertetendus "Väike Versailles" 2. veebr. ja 3. märtsil Estonias, "Mustlasvanker" 5. veebr. Estonias, Eesti Vabariigi 90. sünnipäevale pühendatud kontsertõhtust 7. veebr. Kuressaare Kultuurikeskuses, kontserdist "Vivaldi "Aastaajad"" 1. veebr. Pärnu Kontserdimajas ja 2. veebr. Jõhvi Kontserdimajas

  19. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: ansambli Metsatöll heliplaadi "Iivakivi" esitluskontsertidest 7. märtsil Tallinnas klubis Hollywood ja 8. märtsil Tartu Sadamateatris, Ultima Thule sünnipäevakontserdist 7. märtsil Tallinnas Rock Cafés, Jäääär 8. märtsil Rock Cafés, Koit Toome ja Uku Suviste 12. märtsil Pärnu kontserdimajas, Kuninglik kvintett 8. märtsil Kiviõli rahvamajas, "Naerata nüüd jälle sa" (Maarja-Liis Ilus, Alen Veziko, Margus Vaher, Andre Hein, Raimondo Laikre) 9. märtsil Vanemuise kontserdimajas, "Kaunimad... su elus" (ansambel Kaunimate Aastate Vennaskond) 7. märtsil Jõhvi kontserdimajas, 8. märtsil Vanemuise kontserdimajas ja 9. märtsil Pärnu kontserdimajas, Tarmo ja Toomas Urb 8. märtsil Viljandi kultuurimajas, Koit Toome 7. märtsil Tartu Jaani kirikus, Noorkuu naistepäevakontsert 8. märtsil Rakvere spordihallis, Eesti heliloojate armastuslaulud ETV tütarlastekoori esituses 8. märtsil Jõhvi kontserdimajas, Brides in Bloom + DJ Kahurid 8. märtsil Tallinnas klubis Woodstock, Richard Clayderman 11. märtsil Estonia kontserdisaalis

  20. Sõda, viin, naised ja surm / Vaapo Vaher

    Index Scriptorium Estoniae

    Vaher, Vaapo, 1945-

    2005-01-01

    Tutvustus: Gelassimov, Andrei. Janu / vene k. tlk. Jaan Ross. Tallinn : Kultuurileht, 2005. (Loomingu Raamatukogu) ; Austen, Jane. Mõistus ja tunded / inglise k. tlk. Karin Suursalu. Tallinn : Tänapäev, 2005 ; Kiik, Heino. Ole usin : 1948-1954. Tartu : Ilmamaa, 2005 ; Palm, August. Villem Reiman : [1861-1917]. 2., täiend. tr. Tartu : Ilmamaa, 2004

  1. Juudi naise pilt purustas hinnarekordi / Eda Post

    Index Scriptorium Estoniae

    Post, Eda, 1983-

    2006-01-01

    Miljardär Roland Lauderile kuuluv New Yorgi saksa ja austria kunsti muuseum Neue Galerie ostis 135 miljoni dollari eest austria kunstniku Gustav Klimti õlimaali "Kuldne Adele" Adele Bloch-Bauerist. Lähemalt maali valmimisest ja saatusest. Bloch-Baueri kunstikogu saatusest

  2. Lähme, naised / Tiina Kuuler

    Index Scriptorium Estoniae

    Kuuler, Tiina, 1969-

    2008-01-01

    Muusikasündmustest: rockansamblite Sõpruse Puiestee, Dirty Diana ja Shotgun Suicide peost 15. veebr. Rock Cafés, folklooripeost Pärnus Rääma Nooruse majas, klubi Woodstocki 5. sünnipäeva tähistamisest 15. ja 16. veebr., Ultima Thule kontserdist 15. veebr. Tartu Rockiklubis, festivalist "Eesti teater Estonias"16.-23. veebr.Rahvusooperis Estonia, kontsertidest "Küünlavalgel" 19.-21. veebr. Tallinna Matkamajas, prantsuse duo 2G Kevadjazzil 2008 15. veebr. Tartus Athena keskuses, Raadio Elmari juubelipeost 22. veebr. Pärnu kuursaalis, rootsi bändi Soilwork ja Path Of No Return kontserdist 20. veebr. Tallinnas Rock Cafés

  3. Sentimentalsed naised ja vagased vaimud / Sven Karja

    Index Scriptorium Estoniae

    Karja, Sven, 1968-

    2006-01-01

    Mängufilm "Libahundi needus" : stsenaristid Margus Kasterpalu, Ilmar Raag ja Rainer Sarnet : režissöör Rainer Sarnet : osades Katariina Lauk, Rene Reinumägi : Shop of Dreams - Eesti Televisioon 2005. Lisatud R. Sarneti filmograafia lk. 115

  4. Naised, keda mehed rajal kardavad / Helen Teesalu

    Index Scriptorium Estoniae

    Teesalu, Helen

    2008-01-01

    Vt. ka Postimees : na russkom jazõke : Avto i Tehnika 26. sept., lk. 4. CCG ehk Car Club Girls on Eesti ainuke ametlik naiste autoklubi, mille liikmed teevad võidusõidu- ja kiirendusrajal silmad ette nii mõnelegi mehele

  5. An alternating GluN1-2-1-2 subunit arrangement in mature NMDA receptors.

    Directory of Open Access Journals (Sweden)

    Morgane Riou

    Full Text Available NMDA receptors (NMDARs form glutamate-gated ion channels that play a critical role in CNS physiology and pathology. Together with AMPA and kainate receptors, NMDARs are known to operate as tetrameric complexes with four membrane-embedded subunits associating to form a single central ion-conducting pore. While AMPA and some kainate receptors can function as homomers, NMDARs are obligatory heteromers composed of homologous but distinct subunits, most usually of the GluN1 and GluN2 types. A fundamental structural feature of NMDARs, that of the subunit arrangement around the ion pore, is still controversial. Thus, in a typical NMDAR associating two GluN1 and two GluN2 subunits, there is evidence for both alternating 1/2/1/2 and non-alternating 1/1/2/2 arrangements. Here, using a combination of electrophysiological and cross-linking experiments, we provide evidence that functional GluN1/GluN2A receptors adopt the 1/2/1/2 arrangement in which like subunits are diagonal to one another. Moreover, based on the recent crystal structure of an AMPA receptor, we show that in the agonist-binding and pore regions, the GluN1 subunits occupy a "proximal" position, closer to the central axis of the channel pore than that of GluN2 subunits. Finally, results obtained with reducing agents that differ in their membrane permeability indicate that immature (intracellular and functional (plasma-membrane inserted pools of NMDARs can adopt different subunit arrangements, thus stressing the importance of discriminating between the two receptor pools in assembly studies. Elucidating the quaternary arrangement of NMDARs helps to define the interface between the subunits and to understand the mechanism and pharmacology of these key signaling receptors.

  6. Electrical properties of Ba(Dy1/2Nb1/2)O3 ceramic

    Science.gov (United States)

    Nath, K. Amar; Chandra, K. P.; Dubey, K.; Prasad, K.

    2016-05-01

    Polycrystalline Ba(Dy1/2Nb1/2)O3 was prepared using a high-temperature solid-state reaction method. X-ray diffraction analysis indicated the formation of a single-phase cubic structure having space group Pm3m. AC impedance plots as a function of frequency at different temperatures were used to analyse the electrical behaviour of the sample, which indicated the negative temperature coefficient of resistance character. Complex impedance analysis targeted non-Debye type dielectric relaxation. Frequency dependent ac conductivity data obeyed Jonscher's power law. The apparent activation energy was estimated to be 0.97 eV at 1 kHz.

  7. Sandwiched trilayer of Bethe lattices in the form of spin-(1/2,1,1/2)

    Energy Technology Data Exchange (ETDEWEB)

    Albayrak, Erhan, E-mail: albayrak@erciyes.edu.t [Erciyes University, Department of Physics, 38039 Kayseri (Turkey); Aker, Aynur [Erciyes University, Department of Physics, 38039 Kayseri (Turkey)

    2010-11-15

    The sandwiched trilayer of Bethe lattices in the form of the spins with spin-(1/2,1,1/2) Ising model is studied in terms of the recursion relations with either ferromagnetic or antiferromagnetic type bilinear interactions between the nearest-neighbor (NN) spins. The ground-state (GS) phase diagrams are obtained and it was found that the model presents six different GS phase configurations. In order to obtain the phase diagrams, the thermal variations of the order-parameter, spin-spin correlation functions and free energy are analyzed and different topological phase diagrams are obtained. It was found that the system exhibits different critical behaviors such as, second- and first-order phase transitions, tricritical and bicritical points for the values of the coordination numbers q=3,4 and 6.

  8. Structures and Properties of 1,2,3-Triazoles and 1,2,4-Triazoles

    Institute of Scientific and Technical Information of China (English)

    LU Ya-Lin; GONG Xue-Dong; JU Xue-Hai; JI Guang-Fu; XIAO He-Ming

    2006-01-01

    In this paper, the fully optimized molecular geometries and electronic structures of six 1,2,3- and 1,2,4-triazoles were calculated using density functional theory B3LYP/6-311G** method. The salvation energies were obtained by SCRF in THF. The results show that the total energies of F are the lowest both in gas and liquid phases, and the order of thermodynamic stabilities of the title compounds is F>D>C>B>E>A. Their frontier orbital energy gaps and electron delocalization also support that F is the most stable. All the computed conclusions are in good agreement with the experiments. Vibrational frequencies of the title compounds were computed. The thermodynamic properties and their temperature curves of six compounds were obtained by using the statistical thermodynamic method with the temperature ranging from 200 to 1000 K.

  9. Crystalline 1H-1,2,3-triazol-5-ylidenes

    Energy Technology Data Exchange (ETDEWEB)

    Bertrand, Guy; Gulsado-Barrios, Gregorio; Bouffard, Jean; Donnadieu, Bruno

    2016-08-02

    The present invention provides novel and stable crystalline 1H-1,2,3 triazolium carbenes and metal complexes of 1H-1,2,3 triazolium carbenes. The present invention also provides methods of making 1H-1,2,3 triazolium carbenes and metal complexes of 1H-1,2,3 triazolium carbenes. The present invention also provides methods of using 1H-1,2,3 triazolium carbenes and metal complexes of 1H-1,2,3 triazolium carbenes in catalytic reactions.

  10. Study of hypercharge exchange processes 0{sup -}1/2+{yields}1{sup -} 1/2+; Estudio de procesos 0-1/2+{yields}1-1/2+ con intercambio de hipercarga

    Energy Technology Data Exchange (ETDEWEB)

    Albajar Molera, M. c.; Aguilar Beniter de Lugo, M.

    1981-07-01

    In this work we present a formalism for the reconstruction of the transitivity amplitudes governing the processes of the type 0-1/2+{yields}1-1/2+. The formalism uses the information contained in the decay angular correlations and takes into account the existence of mixed spin configurations in the final state 0-1/2+{yields}(0{down_arrow}, 1-)1/2+ (Author) 10 refs.

  11. Rh-Catalyzed Asymmetric Hydrogenation of 1,2-Dicyanoalkenes.

    Science.gov (United States)

    Li, Meina; Kong, Duanyang; Zi, Guofu; Hou, Guohua

    2017-01-06

    A highly efficient enantioselective hydrogenation of 1,2-dicyanoalkenes catalyzed by the complex of rhodium and f-spiroPhos has been developed. A series of 1,2-dicyanoalkenes were successfully hydrogenated to the corresponding chiral 1,2-dicyanoalkanes under mild conditions with excellent enantioselectivities (up to 98% ee). This methodology provides efficient access to the asymmetric synthesis of chiral diamines.

  12. 5 CFR 1.2 - Extent of the competitive service.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Extent of the competitive service. 1.2 Section 1.2 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES COVERAGE AND DEFINITIONS (RULE I) § 1.2 Extent of the competitive service. The competitive service shall include: (a) All...

  13. 43 CFR § 2812.1-2 - Contents.

    Science.gov (United States)

    2015-10-01

    ... 43 Public Lands: Interior 2 2015-10-01 2015-10-01 false Contents. § 2812.1-2 Section § 2812.1-2 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Coos Bay Revested Lands § 2812.1-2 Contents. (a) An individual applicant and each member of any...

  14. 1,2 Migration in Carbenoid and Carbene Reactions

    Institute of Scientific and Technical Information of China (English)

    MA Ming; JIANG Nan; SHI Wei-Feng; WANG Jian-Bo

    2003-01-01

    @@ 1,2-Hydride, 1,2-alkyl and 1,2-aryl migrations are common in free carbene chemistry, and they are also fre quently encountered in the reactions of metal carbenes. In some cases, these migration reactions can compete with the typical reactions of metal carbenes, such as X-H (X = Si, C, O, N, S, etc. ) insertions and cyclopropanations. [1] The 1,2-migration also found synthetic application. An example is the SnCl2-promoted 1,2-hydride migration of α-diazo-β-hydroxy esters, known as Roskamp homologation, which leads to the formation of β-keto esters. [2

  15. Word Criticality Analysis. MOS: 13E. Skill Level 1 & 2.

    Science.gov (United States)

    1981-09-01

    2-1M.,1 2-141, -5, aiSi 220, -4. 227, -1,*2 FREGUM1V -262.4 2-2!9, 1 2-258,1 2-256,3. 2-5922-41_2-5.12296 -243 2-7. 2-7,1-121 2-260.1 2-2it - 3,1 2...I5I 3-- 301 .. 4 ID TIV2-2203o 2-333,3145,1- -4 ILLUMIC 4 ~1-394.1-1. 4 INS3SIC1 **301.3 12, 23-2973- -4 0 cp 4 -lo 40- *4 sum6 3- 11,1 3- 10.1 2

  16. Word Criticality Analysis MOS: 15D. Skill Levels 1 & 2.

    Science.gov (United States)

    1981-09-01

    0p -o1 2-91D1 2-290,1 -2- 27002 -2-245,1 2-12101 apcisoti 2-140,2 "P nSNPG2-155,1 ’ 2 PL~1%UNOI:S 2:146,#2 I POSITLIW 2 264,1I __...POSS IALr . ___2*2...UUALLY _ 2-224,1 2 T1,1 - 91,2 2- 92.2 2- 91.1 3 15.1 A- 17s1 3- 16#1 3- 44.2 1- 7201 3- ISO [ 1- I0,i Z TLZ - 94,1 3- 14,1 3- 1.. 3- 12.1 3- 11.1 2- 90,1

  17. Word Criticality Analysis. MOS: 44E. Skill Levels 1 & 2.

    Science.gov (United States)

    1981-09-01

    78.4 2- 64,1 I GLgKP(Ix 2- 62,1 2- 58,1 1 ’ ’. I fMbs WIUf,D LIaT BY 04GE tfTF .PV. 107? PIGE . 1 GE 2- 79,1 I G1M& 2- 32,1 G(1N)EM2- 17,1 2- 137,1 2...0 2 0 n~ 1 . i , - I - I C5MS WIRD LIST BY PIGE 1Yj’© p𔃻L’ 1177 P.GP 6 j 1 EltL 2- 10,1 2- 18,1 2- 12,1 N1 MI IFV 2- 12.1 2- 66 l 2- 57.2 2- 26,1

  18. Substituted 4-hydroxy-1,2,3-triazoles

    DEFF Research Database (Denmark)

    Pippione, Agnese C.; Dosio, Franco; Ducime, Alex;

    2015-01-01

    Bioisosterism and scaffold hopping are two widely used approaches in medicinal chemistry for the purpose of lead optimization. The study highlights the physicochemical properties of the 4-hydroxy-1,2,3-triazole scaffold, a less investigated heterocyclic system. Synthetic strategies to obtain diff......, with the 4-hydroxy-1,2,3-triazole scaffold. The 4-hydroxy-1,2,3-triazole system appears to be useful and versatile in drug design....

  19. 2~(1/2)/2是分数吗?

    Institute of Scientific and Technical Information of China (English)

    李厚明

    2003-01-01

    同学们遇到一道题: 2~(1/2)/2________(填是或不是)分数。同学们争论不休,有的认为2~(1/2)/2是分数,有的认为2~(1/2)/2不是分数,各执一辞,意见不能统一。那么,2~(1/2)/2究竟是不是分数呢? 下面从两方面加以辨析。

  20. Genetics and biochemistry of 1,2-dichloroethane degradation

    NARCIS (Netherlands)

    Janssen, Dick B.; Ploeg, Jan R. van der; Pries, Frens

    1994-01-01

    Dichloroethane (1,2-DCE) is a synthetic compound that is not known to be formed naturally. Nevertheless, several pure microbial cultures are able to use it as a sole carbon source for growth. Degradation of 1,2-DCE proceeds via 2-chloroethanol, chloroacetaldehyde and chloroacetate to glycolate. The

  1. Genetics and biochemistry of 1,2-dichloroethane degradation

    NARCIS (Netherlands)

    Janssen, Dick B.; Ploeg, Jan R. van der; Pries, Frens

    1994-01-01

    Dichloroethane (1,2-DCE) is a synthetic compound that is not known to be formed naturally. Nevertheless, several pure microbial cultures are able to use it as a sole carbon source for growth. Degradation of 1,2-DCE proceeds via 2-chloroethanol, chloroacetaldehyde and chloroacetate to glycolate. The

  2. An efficient synthesis of substituted benzene-1,2-dicarboxaldehydes

    Institute of Scientific and Technical Information of China (English)

    ZHU Peter C; WANG Dei-Haw; LU Kaitao; MANI Neelakandha

    2007-01-01

    Substituted-benzene-1,2-dicarbaldehydes were synthesized by the reaction of substituted-1,2-bis (dibromomethyl) benzenes with fuming sulfuric acid, followed by hydrolysis, The yields were significantly improved by introducing solid sodium bicarbonate into the reaction mixture before hydrolysis and workup.

  3. An efficient synthesis of substituted benzene-1,2-dicarboxaldehydes

    Institute of Scientific and Technical Information of China (English)

    ZHU; Peter; C; WANG; Der-Haw; MANI; Neelakandha

    2007-01-01

    Substituted-benzene-1,2-dicarbaldehydes were synthesized by the reaction of substituted-1,2-bis(dibromomethyl) benzenes with fuming sulfuric acid,followed by hydrolysis. The yields were signifi-cantly improved by introducing solid sodium bicarbonate into the reaction mixture before hydrolysis and workup.

  4. 1,2-Selective Hydrosilylation of Conjugated Dienes

    OpenAIRE

    Parker, Sarah Elizabeth

    2014-01-01

    Selective 1,2-hydrosilylation of 1,3-dienes is a challenging problem to solve for transition metal catalysis. Butadiene, specifically, would be a useful substrate because 3-butenylsilane products have promise as superior coupling reagents for hybrid organic/inorganic materials synthesis. In this thesis, we describe the first selective 1,2-hydrosilylation of conjugated dienes, including butadiene.

  5. Dihydroxylation of 4-substituted 1,2-dioxines

    DEFF Research Database (Denmark)

    Robinson, Tony V; Pedersen, Daniel Sejer; Taylor, Dennis K;

    2009-01-01

    The synthesis of 2-C-branched erythritol derivatives, including the plant sugar (+/-)-2-C-methylerythritol 2, was achieved through a dihydroxylation/reduction sequence on a series of 4-substituted 1,2-dioxines 3. The asymmetric dihydroxylation of 1,2-dioxines was examined, providing access to opt...

  6. Synthesis, spectral characterization and antihaemostatic activity of 1,2,4-triazoles incorporating 1,2,4-triazine rings

    Indian Academy of Sciences (India)

    Ravindra R Kamble; Belgur S Sudha

    2006-03-01

    A simple and high yielding method for the integration of a 1,2,4-triazole ring with 1,2,4-triazine- 5-one (4a-j) has been developed starting from 3-arylsydnones (1a-d). The structures were proved by their spectral data and screened for antihaemostatic activity.

  7. The LDA-1/2 technique: Recent developments

    Science.gov (United States)

    Ferreira, Luiz G.; Pelá, Ronaldo R.; Teles, Lara K.; Marques, Marcelo; Ribeiro, Mauro, Jr.; Furthmüller, Jürgen

    2013-12-01

    This paper is a review of the LDA(GGA)-1/2 method for band calculation. We review the many applications of the method: band gaps, semiconductor interfaces, semiconductor alloys. The number of applications where the method fails is minimal. Leading to results with a precision comparable to Hedin's GW method, LDA-1/2 has the advantage of being orders of magnitude faster. The paper begins by a short theoretical review in which we try not repeat what is already published. Then we present some results that are scattered in the literature. We find that LDA(GGA)-1/2 is the recommended method for excited state energy calculations.

  8. Fernald Silos 1 & 2 Accelerated Waste Retrieval Program Surrogate Development

    Energy Technology Data Exchange (ETDEWEB)

    Mullen, O Dennis; Erian, Fadel F.

    2002-09-01

    Whitepaper describing the rationale and methodology for development of surrogates to be used for testing retrieval and processing systems for the DOE Fernald Silos 1 & 2 wastes. One significant updating/revision is expected.

  9. Global Precipitation Climatology Project (GPCP) - Daily, Version 1.2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Global Precipitation Climatology Project (GPCP) comprises a total of 27 products. The Version 1.2 Daily product covers the period October 1998 to the present,...

  10. 1-[2-(4-Methyl-7-coumarinyloxyethyl]-4-(5-{1-[2-(4-methyl-7-coumarinyloxyethyl]-1H-1,2,3-triazol-4-yl}pentyl-1H-1,2,3-triazole

    Directory of Open Access Journals (Sweden)

    Fernando Cidade Torres

    2016-04-01

    Full Text Available Nature often produces compounds with a high degree of symmetry to reduce structural information and complexity. Synthesis of identical twin drugs, through the linkage of two identical pharmacophoric entities, is a classical strategy to produce more potent and/or selective drugs. Herein, two units of the privileged core of the coumarin hymecromone were linked together using “click chemistry”. Synthesis of 1-[2-(4-Methyl-7-coumarinyloxyethyl]-4-(5-{1-[2-(4-methyl-7-coumarinyloxyethyl]-1H-1,2,3-triazol-4-yl}pentyl-1H-1,2,3-triazole was achieved by coupling of two identical units of an azido coumarin with a symmetrical alkine using copper(I-catalyzed alkyne-azide cycloaddition reaction, in good yields and with complete regioselectivity.

  11. PSCz-1.2 Jy Comparison: A Spherical Harmonics Approach

    OpenAIRE

    1999-01-01

    We perform a detailed comparison of the IRAS PSCz and 1.2-Jy spherical harmonic coefficients of the density and velocity fields in redshift space. The monopole terms predicted from the two surveys show some differences. The mismatch between the velocity monopoles arises from faint sources and disappears when extracting a PSCz subsample of galaxies with fluxes larger than 1.2 Jy. The analysis of PSCz dipole moments confirms the same inconsistencies found by Davis, Nusser and Willick (1996) bet...

  12. 1,2,4-triazine derivatives: Synthesis and biological applications

    Directory of Open Access Journals (Sweden)

    Mohammad Arshad

    2014-04-01

    Full Text Available 1,2,4-Triazines are the six membered heterocyclic compounds possessing three nitrogen in its structure with general formula C3H3N3. 1,2,4-Triazines and its derivatives have been found to exhibit the variety of biological applications such as antifungal, anti-HIV, anticancer, antiinflammatory, analgesic and antihypertensive, cardiotonic, neuroleptic, nootropic, antihistaminergic, tuberculostatic, antiviral, anti-protozoal, estrogen receptor modulators, antimalarial, cyclin-dependent kinase inhibitors, antimicrobial and antiparasitic activities.

  13. SU(1,2) invariance in two-dimensional oscillator

    CERN Document Server

    Krivonos, Sergey

    2016-01-01

    Performing the Hamiltonian analysis we explicitly established the canonical equivalence of the deformed oscillator, constructed in arXiv:1607.03756[hep-th], with the ordinary one. As an immediate consequence, we proved that the SU(1,2) symmetry is the dynamical symmetry of the ordinary two-dimensional oscillator. The characteristic feature of this SU(1,2) symmetry is a non-polynomial structure of its generators written it terms of the oscillator variables.

  14. 15 CFR 1.2 - Description and design.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Description and design. 1.2 Section 1... COMMERCE § 1.2 Description and design. (a) The Act of February 14, 1903 (32 Stat. 825, as amended) (15 U.S... the words: Department of Commerce United States of America (b) The design of the approved seal is as...

  15. 1,2-Bis(2-methoxy-6-formylphenoxyethane

    Directory of Open Access Journals (Sweden)

    Hongqi Li

    2011-02-01

    Full Text Available In the title compound [systematic name: 3,3′-dimethoxy-2,2′-(ethane-1,2-diyldioxydibenzaldehyde], C18H18O6, prepared from 1,2-dibromoethane and ortho-vanillin in the presence of sodium carbonate, the two vanillin units are linked via a CH2–CH2 bridge. The two benzene rings are inclined at a dihedral angle of 41.6 (5°.

  16. Measurement and Correlation of Vapor-Liquid Equilibrium for Binary System 1,2-Epoxycyclohexane+1,2-Dichloroethane

    Institute of Scientific and Technical Information of China (English)

    周彩荣; 王海峰; 石晓华; 蒋登高

    2013-01-01

    Vapor-liquid equilibrium data (T, x, y) of binary system 1,2-epoxycyclohexane+1,2-dichloroethane were determined experimentally by using a modified ROSE-Williams equilibrium vaporization system at 101.33 kPa. The results show that this binary system does not have azeotropic point. The vapor-liquid equilibrium data are in thermodynamic consistency. The binary interaction parameters in the Wilson equation are presented with the correlation of vapor-liquid equilibrium data. The measurements of liquid phase composition and bubble point tem-perature are well represented by the Wilson equation. Values of vapor molecular fractions and activity coefficients from the Wilson equation are presented. This work provides important engineering data for the separation of 1,2-dichloroethane and 1,2-epoxycyclohexane .

  17. Synthesis, chemical reactivity and fungicidal activity of pyrido[1,2-b][1,2,4]triazine derivatives

    Energy Technology Data Exchange (ETDEWEB)

    Ibrahim, Magdy A.; Abdel-Rahman, Reda M.; Abdel-Halim, Ali M.; Ibrahim, Salah S.; Allimony, Hassan A. [Ain Shams University, Roxy, Cairo (Egypt). Faculty of Education. Dept. of Chemistry], e-mail: magdy_ahmed1977@yahoo.com

    2009-07-01

    The synthesis of some new pyrido[1,2-b][1,2,4]triazines (2-12) was achieved by cyclocondensation of 4-aryl-1,6-diamino-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles (1a,b) with {alpha},{beta}-bifunctional compounds. Pyrido[1,2:2'3']triazino[5'6'-f]triazines (13-14) were also prepared. The behavior of 1a,b toward interactions with indole-2,3-dione and its N-acetyl analogue have been studied under different reaction conditions. The structures of the new products have been deduced from elemental analysis and spectral data (UV, IR, {sup 1}H NMR, {sup 13}C NMR and mass spectra). The new synthesized compounds were screened for their antifungal activities. (author)

  18. Dielectric relaxation in 0-3 PVDF-Ba(Fe1/2Nb1/2)O3 composites

    Science.gov (United States)

    Chandra, K. P.; Singh, Rajan; Kulkarni, A. R.; Prasad, K.

    2016-05-01

    (1-x)PVDF-xBa(Fe1/2Nb1/2)O3 ceramic-polymer composites with x = 0.025, 0.05, 0.10, 0.15 were prepared using melt-mixing technique. The crystal symmetry, space group and unit cell dimensions were determined from the XRD data of Ba(Fe1/2Nb1/2)O3 using FullProf software, whereas crystallite size and lattice strain were estimated using Williamson-Hall approach. The distribution of Ba(Fe1/2Nb1/2)O3 particles in the PVDF matrix were examined on the cryo-fractured surfaces using a scanning electron microscope. Cole-Cole and pseudo Cole-Cole analysis suggested the dielectric relaxation in this system to be of non-Debye type. Filler concentration dependent real and imaginary parts of dielectric constant as well as ac conductivity data followed definite trends of exponential growth types of variation.

  19. Near infrared rubidium 62P3/2,1/2→62S1/2 laser

    Science.gov (United States)

    Moran, Paul J.; Richards, Ryan M.; Rice, Christopher A.; Perram, Glen P.

    2016-09-01

    An optically pumped near infrared rubidium (Rb) pulsed, mirrorless laser has been demonstrated in a heat pipe along both the 62P3/2-62S1/2 transition at 2.73 μm and the 62P1/2-62S1/2 transition at 2.79 μm. The bleached limit, slope efficiency, and maximum laser output energy of the near infrared Rb laser scale linearly with increasing Rb density, contrary to prior results. Previously, a maximum output energy of ~5 nJ had been observed before a rollover occurred in the scaling of output energy with rubidium concentration. In this experiment, the maximum laser output energy observed was ~100 nJ, with no indication of any scaling limitation. A maximum slope efficiency of 1.7×10-4 was observed. A small percentage of the pump photons were absorbed even at the maximum Rb density attainable in the heat pipe, indicating that laser efficiency could be scaled to near the quantum efficiency. Additionally, the hyperfine structure and absorption spectral profile of the 52S1/2-62P1/2 and 52S1/2-62P3/2 (blue) pump transitions were studied using a cw pump source.

  20. The WZNW model on PSU(1,1|2)

    CERN Document Server

    Götz, G; Schomerus, V; Gotz, Gerhard; Quella, Thomas; Schomerus, Volker

    2007-01-01

    According to the work of Berkovits, Vafa and Witten (hep-th/9902098), the non-linear sigma model on the supergroup PSU(1,1|2) is the essential building block for string theory on AdS(3)xS(3)xT(4). Models associated with a non-vanishing value of the RR flux can be obtained through a psu(1,1|2) invariant marginal deformation of the WZNW model on PSU(1,1|2). We take this as a motivation to present a manifestly psu(1,1|2) covariant construction of the model at the Wess-Zumino point, corresponding to a purely NSNS background 3-form flux. At this point the model possesses an enhanced psu(1,1|2) current algebra symmetry whose representation theory, including explicit character formulas, is developed systematically in the first part of the paper. The space of vertex operators and a free fermion representation for their correlation functions is our main subject in the second part. Contrary to a widespread claim, bosonic and fermionic fields are necessarily coupled to each other. The interaction changes the supersymmet...

  1. Word Criticality Analysis. MOS: 31M. Skill Levels 1 & 2.

    Science.gov (United States)

    1981-09-01

    401 1 1:./ TCC .6CI6 9 5’ 2 .𔃻 289*2 208.1 2:4, 1 279,1 I AN/ TCC ..61 71ll 58 3.1 2".4 2 c ,2 268.2 266.3 16582 264.l1 5@8.1 23742 21501 131,11f 2 3...91#z 90,2 821&. C* 21 0*) 67,1 AN/ TCC - 69 39#1 34.1 7.3 04;2 28S.:1 2051 241 2’r 7* @01 291 4. 5. 63*1 4051 I AN/ t rCC.. 7 100,1 7 1 512CJ9~ , 4.1...z 2 s~rcv 611’ 350AI 346.2 280,1 t.1 2.1 2 sic 49P2 Zfl*2 eas1 51.1 23!.1 5#1 7.2 to) 202.1 #00#1 2 SLAVr 6104 !32*6 31.1 44.4 2t#2 2 5f,( OER 1

  2. BRCA1/2 associated hereditary breast cancer

    Institute of Scientific and Technical Information of China (English)

    Li-song TENG; Yi ZHENG; Hao-hao WANG

    2008-01-01

    Breast cancer is one of the leading causes of death in women today. Some of the patients are hereditary, with a large proportion characterized by mutation in BRCA1 and/or BRCA2 genes. In this review, we provide an overview of these two genes,focusing on their relationship with hereditary breast cancers. BRCA1/2 associated hereditary breast cancers have unique features that differ from the general breast cancers, including alterations in cellular molecules, pathological bases, biological behavior, and a different prevention strategy. But the outcome of BRCA1/2 associated hereditary breast cancers still remains controversial;further studies are needed to elucidate the nature of BRCA1/2 associated hereditary breast cancers.

  3. Extended cluster spin-1/2 XXZ chain

    Science.gov (United States)

    Tahvili, Masoumeh; Mahdavifar, Saeed

    2017-01-01

    We study the quantum phase transitions in the extended cluster spin-1/2 XXZ chain, which is equivalent to a 1D spin-1/2 XXZ model with three-spin interaction. The ground state phase diagram of the 1D spin-1/2 anisotropic XXZ model is known. Depending on the value of the anisotropy parameter, the ground state exhibits the ordering of the Luttinger liquid (LL), the Neel and the saturated ferromagnetic phases. In the absence of the anisotropy, it was shown that the three-spin interaction induces a quantum phase transition between two kinds of the LL phases. In the presence of the anisotropy, by using the analytical and numerical methods, the extended ground state phase diagram of the model is obtained.

  4. 3-[Chloro(phenylmethyl]-6-methyl-1,2-benzoxazole

    Directory of Open Access Journals (Sweden)

    M. Kayalvizhi

    2011-11-01

    Full Text Available The title compound, C15H12ClNO, is a functionalized 1,2-benzoxazole with a chloro(phenylmethyl substituent. The molecule is V-shaped, the dihedral angle between the mean plane of the 1,2-benzoxazole system [maximum deviation = 0.023 (3 Å for the N atom] and the phenyl ring being 70.33 (14°. There are no hydrogen-bonding interactions in the crystal structure, which is stabilized by van der Waals interactions only.

  5. An Efficient Preparation of 1,2-Diamino-1-phenylheptane

    Directory of Open Access Journals (Sweden)

    P. T. Perumal

    2002-06-01

    Full Text Available A convenient four-step method for the preparation of the lipophilic vicinal diamine 1,2-diamino-1-phenylheptane is described. Condensation involving octan-2-one, benzaldehyde and ammonia is reported. Regioselective Schmidt rearrangement of 2,6-diphenyl-3-pentyl-piperidin-4-one (1 to 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one (3 is presented. Hydrolysis of 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one to 1,2-diamino-1-phenylheptane (4 is also reported for the first time.

  6. [Hydrogen bis(1,2,4-triazole] 1,2,4-triazolium bis(3-carboxy-4-hydroxybenzenesulfonate 1,2,4-triazole disolvate

    Directory of Open Access Journals (Sweden)

    Ming-qiang Qiu

    2010-08-01

    Full Text Available The title compound, C2H4N3+·[H(C2H3N32]+·2C7H5O6S−·2C2H3N3, consists of two types of 1,2,4-triazole monocation, one protonated at the 2-site lying across a twofold axis and the other protonated at the 4-site with the H atom disordered over a center of symmetry, a 5-sulfosalicylate anion and a neutral 1,2,4-triazole molecule. The component ions are linked into a three-dimensional network by a combination of N—H...O, N—H...N, O—H...O, O—H...N, C—H...O and C—H...N hydrogen bonds. In addition, benzene–benzene π–π interactions of 3.942 (2 Å [interplanar spacing = 3.390 (2 Å] and C—O...π (3.331 Å interactions are observed.

  7. 1,2,4-Butanetriol: Analysis and Synthesis

    Science.gov (United States)

    1982-12-08

    ANHYDRIDE ........................41 CLEAVAGE OF CYCLIC ETHERS. .. ....... ......... 43 REFERENCES .. ... .......... .......... ......... 45... NOMENCLATURE .. ... .......... .......... ........ 49 1. iii/jy NSWC TR 82-380 ILLUSTRATIONS Figure Page I HYDROGENATION OF DIETHYLMALATE IN ETHANOL OVER NIKKI...of acetic acid, acetic anhydride , and sul Uric acid yielded 1,2,4-butanetriol triacetate. Subsequent methanolysis of the acetate produced BT. Wagaman

  8. 36 CFR 1.2 - Applicability and scope.

    Science.gov (United States)

    2010-07-01

    ... to the jurisdiction of the United States located within the boundaries of the National Park System... Section 1.2 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR GENERAL... administered by the National Park Service; (2) The boundaries of lands and waters administered by the...

  9. Synthesis of Poly(m-pyridylene-1,2-diphenylvinylene

    Directory of Open Access Journals (Sweden)

    Rosana S. Montani

    2000-03-01

    Full Text Available The synthesis by dehalogenating polycondensation and characterization of a new soluble conjugated polymer, poly(m-pyridylene-1,2-diphenylvinylene, DP-PPyV, is reported here. It shows good mechanical properties and a λmax = 330 nm. The maximum intensity peak of MALDI-TOF corresponds to 1.800 Da.

  10. Game-Review: Trilogie Mass Effect 1, 2 und 3

    Directory of Open Access Journals (Sweden)

    Karl H. Stingeder

    2013-03-01

    Full Text Available Karl Stingeder hat als Spieletester die Science Fiction Trilogie Mass Effect (1,2 und 3 rezensiert. Er berichtet von der inneren Vielfalt und dem spannenden Gameplay. Tauchen Sie ein in eine Welt, die ihnen eine lange Spielzeit garantiert und genießen Sie die Pracht dieser Kunstwerke.

  11. Spin diffusion in anisotropic Heisenberg chains: S{>=}1/2

    Energy Technology Data Exchange (ETDEWEB)

    Huber, D.L., E-mail: huber@src.wisc.edu [Physics Department, University of Wisconsin-Madison, 1150 University Avenue, Madison WI 53706 (United States)

    2012-11-01

    In this paper, we investigate spin diffusion in Heisenberg chains with uniaxial nearest-neighbor interactions. The approach followed is based on an analysis of the infinite-temperature longitudinal spin density and spin current correlation functions. For S=1/2, exact results are presented for the time-dependent correlation functions in the XY limit. Away from this limit, the second and fourth moments of the Fourier transform of the spin density correlation function provide information about spin dynamics for arbitrary values of the spin. The moments are used in an assessment of the accuracy of the Gaussian approximation for the spin diffusion constant for S=1/2. The general behavior of the Gaussian approximation when S>1/2 is discussed, and numerical results for the spin diffusion constant are presented for S=1/2, 1, 3/2, 2 and in the classical limit. A moment-based criterion for the boundary in reciprocal space between diffusive and non-diffusive dynamics that applies to arbitrary values of the spin is presented.

  12. Transformation and biodegradation of 1,2,3-trichloropropane (TCP)

    NARCIS (Netherlands)

    Samin, Ghufrana; Janssen, Dick B.

    2012-01-01

    1,2,3-Trichloropropane (TCP) is a persistent groundwater pollutant and a suspected human carcinogen. It is also is an industrial chemical waste that has been formed in large amounts during epichlorohydrin manufacture. In view of the spread of TCP via groundwater and its toxicity, there is a need for

  13. Bis(4H-1,2,4-triazol-3-yldisulfane

    Directory of Open Access Journals (Sweden)

    Dongsheng Liu

    2008-01-01

    Full Text Available The title compound, C4H4N6S2, was synthesized by the reaction of 3-mercapto-1H-1,2,4-triazole with sodium hydroxide in ethanol. The molecule possesses a crystallographically imposed twofold axis. Intermolecular N—H...N hydrogen bonds link the molecules into chains along the c axis.

  14. A Superfield Formalism of osp(1,2) Covariant Quantization

    CERN Document Server

    Lavrov, P M

    2001-01-01

    We propose a superfield description of osp(1,2) covariant quantization by extending the set of admissibility conditions for the quantum action. We realize a superfield form of the generating equations, specify the vacuum functional and obtain the corresponding transformations of extended BRST symmetry.

  15. Facile Synthesis of 1, 2-Diazepine Derivatives under Microwave Irradiation

    Institute of Scientific and Technical Information of China (English)

    Jin Xian WANG; Xiao Ning SHI; Ke Hu WANG; Xiu Qin MEN

    2004-01-01

    An efficient and convenient synthesis of 3, 5, 7-triaryl-4H-1, 2-diazepine from 2, 4, 6-triarylpyrylium salts and hydrazine in water under microwave irradiation is reported. The same reaction can be conducted using 2, 4, 6-triarylthiopyrylium salts and hydrazine.

  16. Transformation and biodegradation of 1,2,3-trichloropropane (TCP)

    NARCIS (Netherlands)

    Samin, Ghufrana; Janssen, Dick B.

    1,2,3-Trichloropropane (TCP) is a persistent groundwater pollutant and a suspected human carcinogen. It is also is an industrial chemical waste that has been formed in large amounts during epichlorohydrin manufacture. In view of the spread of TCP via groundwater and its toxicity, there is a need for

  17. Biochemical activities of 1,2-dichloroethane (DCA) degrading bacteria

    African Journals Online (AJOL)

    African Journal of Biotechnology ... One of the most widely produced industrial solvents is 1,2-dichloroethane (DCA), a known ... Annual production in the United States, Japan and Europe alone are in excess of ... isolated from South African waste water treatment facilities, were found to belong to the genus Ancylobacter.

  18. The Addition of Bromine to 1,2-Diphenylethene

    Science.gov (United States)

    Amburgey-Peters, Judith C.; Haynes, Leroy W.

    2005-01-01

    The bromination of 1,2-diphenylethene, using a variety of solvents and brominating agents, can be used in both introductory and advanced organic chemistry courses. The reactions can be used to illustrate the effects of changing solvents and reagents, as well as to reveal interesting aspects of organic reaction mechanisms.

  19. ABIOTIC DEHALOGENATION OF 1,2-DICHLOROETHANE AND 1,2-DIBROMETHANE IN AQUEOUS SOLUTION CONTAINING HYDROGEN SULFIDE

    Science.gov (United States)

    The detection of significant levels of halogenated ali- phatic contaminants in groundwater resources in the U- nited States (1, 2) has spurred a considerable effort to understand the various mechanisms-both microbiological and abiotic-by which these compounds may be trans- formed...

  20. New Features in CMMI V1.2%CMMI V1.2 版本的新特征

    Institute of Scientific and Technical Information of China (English)

    许东; 刘宗田

    2007-01-01

    最新发布的CMMI V1.2 模型做了很多的改进.将原先的模型CMMI-SE/SW/IPPD进行了整合,更改了模型的名称:CMMI-SE/SW/改为用于开发的CMMI模型CMMI-DEV v1.2.CMMI v1.2 产品集支持开发、服务和获取过程,CMMI-DEV是其中的一种并首先发布,其它的CMMI套件在2007年陆续发布."附加"是用来扩展模型的,如CMMI-DEV+IPPD,表示某些过程域是和IPPD中的目标和实践结合起来使用.新版本还将CMMI的两种表示方式(连续和阶段式)合并在一个文档中表述.在CMMI V1.2 版本中,模型的表述、术语、过程域都有相应的改进.

  1. HMGB1/2 can target DNA for illegitimate cleavage by the RAG1/2 complex

    Directory of Open Access Journals (Sweden)

    Swanson Patrick C

    2009-03-01

    Full Text Available Abstract Background V(DJ recombination is initiated in antigen receptor loci by the pairwise cleavage of recombination signal sequences (RSSs by the RAG1 and RAG2 proteins via a nick-hairpin mechanism. The RSS contains highly conserved heptamer (consensus: 5'-CACAGTG and nonamer (consensus: 5'-ACAAAAACC motifs separated by either 12- or 23-base pairs of poorly conserved sequence. The high mobility group proteins HMGB1 and HMGB2 (HMGB1/2 are highly abundant architectural DNA binding proteins known to promote RAG-mediated synapsis and cleavage of consensus recombination signals in vitro by facilitating RSS binding and bending by the RAG1/2 complex. HMGB1/2 are known to recognize distorted DNA structures such as four-way junctions, and damaged or modified DNA. Whether HMGB1/2 can promote RAG-mediated DNA cleavage at sites lacking a canonical RSS by targeting or stabilizing structural distortions is unclear, but is important for understanding the etiology of chromosomal translocations involving antigen receptor genes and proto-oncogene sequences that do not contain an obvious RSS-like element. Results Here we identify a novel DNA breakpoint site in the plasmid V(DJ recombination substrate pGG49 (bps6197 that is cleaved by the RAG proteins via a nick-hairpin mechanism. The bps6197 sequence lacks a recognizable heptamer at the breakpoint (5'-CCTGACG-3' but contains a nonamer-like element (5'-ACATTAACC-3' 30 base pairs from the cleavage site. We find that RAG-mediated bps6197 cleavage is promoted by HMGB1/2, requiring both HMG-box domains to be intact to facilitate RAG-mediated cleavage, and is stimulated by synapsis with a 12-RSS. A dyad-symmetric inverted repeat sequence lying 5' to the breakpoint is implicated as a target for HMGB1/2 activity. Conclusion We have identified a novel DNA sequence, called bps6197, that supports standard V(DJ-type cleavage despite the absence of an apparent heptamer motif. Efficient RAG-mediated bps6197 cleavage requires

  2. HMGB1/2 can target DNA for illegitimate cleavage by the RAG1/2 complex.

    Science.gov (United States)

    Zhang, Ming; Swanson, Patrick C

    2009-03-24

    V(D)J recombination is initiated in antigen receptor loci by the pairwise cleavage of recombination signal sequences (RSSs) by the RAG1 and RAG2 proteins via a nick-hairpin mechanism. The RSS contains highly conserved heptamer (consensus: 5'-CACAGTG) and nonamer (consensus: 5'-ACAAAAACC) motifs separated by either 12- or 23-base pairs of poorly conserved sequence. The high mobility group proteins HMGB1 and HMGB2 (HMGB1/2) are highly abundant architectural DNA binding proteins known to promote RAG-mediated synapsis and cleavage of consensus recombination signals in vitro by facilitating RSS binding and bending by the RAG1/2 complex. HMGB1/2 are known to recognize distorted DNA structures such as four-way junctions, and damaged or modified DNA. Whether HMGB1/2 can promote RAG-mediated DNA cleavage at sites lacking a canonical RSS by targeting or stabilizing structural distortions is unclear, but is important for understanding the etiology of chromosomal translocations involving antigen receptor genes and proto-oncogene sequences that do not contain an obvious RSS-like element. Here we identify a novel DNA breakpoint site in the plasmid V(D)J recombination substrate pGG49 (bps6197) that is cleaved by the RAG proteins via a nick-hairpin mechanism. The bps6197 sequence lacks a recognizable heptamer at the breakpoint (5'-CCTGACG-3') but contains a nonamer-like element (5'-ACATTAACC-3') 30 base pairs from the cleavage site. We find that RAG-mediated bps6197 cleavage is promoted by HMGB1/2, requiring both HMG-box domains to be intact to facilitate RAG-mediated cleavage, and is stimulated by synapsis with a 12-RSS. A dyad-symmetric inverted repeat sequence lying 5' to the breakpoint is implicated as a target for HMGB1/2 activity. We have identified a novel DNA sequence, called bps6197, that supports standard V(D)J-type cleavage despite the absence of an apparent heptamer motif. Efficient RAG-mediated bps6197 cleavage requires the presence of HMGB1/2, is stimulated by

  3. Sporothrix schenckii (sensu strict S. globosa) mating type 1-2 (MAT1-2) gene.

    Science.gov (United States)

    Kano, Rui; Anzawa, Kazushi; Mochizuki, Takashi; Nishimoto, Katsutaro; Hiruma, Masataro; Kamata, Hiroshi; Hasegawa, Atsuhiko

    2013-09-01

    Sporotix schenckii is a pathogenic fungus that causes human and animal sporotrichosis, and based on morphology of the sessile conidia and molecular analysis, it was recently recognized as a species complex comprising at least the following six sibling species: S. albicans, S. brasiliensis, S. globosa, S. luriei, S. mexicana and S. schenckii. However, apart from S. schenckii sensu strict, only S. brasiliensis, S. globosa and S. luriei are associated with human and animal infection. S. globosa has been most commonly isolated in Asia, Europe and the USA; therefore, molecular epidemiological study for S. globosa is important in relation to human sporotrichosis in Japan. To the best of our knowledge, this is the first study to determine the mating type 1-2 (MAT1-2) gene of Sporothrix schenckii with the aim of understanding the taxonomy of the genus Sporothrix. The MAT1-2 gene (1618 bp) encodes a protein sequence of 198 amino acids. Reverse transcription polymerase chain reaction analysis also detected MAT1-2 gene mRNA expression in all of the S. schenckii strains examined, indicating that this gene is expressed in S. schenckii cells. Phylogenetic analysis of the MAT1-2 gene fragments of Ophiostoma himal-ulmi, O. novo-ulmi, O. ulmi and S. schenckii indicated that these isolates could be classified into four clusters. MAT1-1 gene-specific polymerase chain reaction was positive in 15 isolates, but negative in four human isolates and one feline isolate.

  4. Beam current transformer (BCT) for experiment WA1/2

    CERN Multimedia

    CERN PhotoLab

    1978-01-01

    In experiment WA1/2, a 400 GeV proton beam from the SPS was directed at a target, downstream of which a hadron line selected, in several narrow momentum bands, a beam of either pi+ and K+ or pi- and K-. These neutrino-parent particles, before entering a 292 m long decay tunnel, passed through a set of 2 BCTs of a design seen here. They measured the hadron intensity (10^10 to 10^11 particles/pulse) with a precision of the order of 1%. There were 2 of them, for enhanced precision and confidence. After the discovery of neutral currents in the Gargamelle-experiment, WA1/2 was the first follow-up, high-precision experiment (Z.Phys.C35, 443-452, 1987 and Z.Phys.C45, 361-379, 1990). See also 7706516X.

  5. Hexamethylenetetramine-4-nitrocatechol-water (1/2/1).

    Science.gov (United States)

    Chantrapromma, Suchada; Usman, Anwar; Fun, Hoong Kun; Poh, Bo Long; Karalai, Chatchanok

    2002-11-01

    In the title adduct, 1,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane-4-nitrobenzene-1,2-diol-water (1/2/1), C(6)H(12)N(4).2C(6)H(5)NO(4).H(2)O, the hexamethylenetetramine molecule acts as an acceptor of intermolecular O-H.N hydrogen-bonding interactions from the water molecule and the hydroxy groups of one of the two symmetry-independent 4-nitrocatechol molecules. The structure is built from molecular layers which are stabilized by three intermolecular O-H.O, two intermolecular O-H.N and four intermolecular C-H.O hydrogen bonds. The layers are further interconnected by one additional intermolecular O-H.N and two intermolecular C-H.O hydrogen bonds.

  6. Click chemistry: 1,2,3-triazoles as pharmacophores.

    Science.gov (United States)

    Agalave, Sandip G; Maujan, Suleman R; Pore, Vandana S

    2011-10-04

    The copper(I)-catalyzed 1,2,3-triazole-forming reaction between azides and terminal alkynes has become the gold standard of 'click chemistry' due to its reliability, specificity, and biocompatibility. Applications of click chemistry are increasingly found in all aspects of drug discovery; they range from lead finding through combinatorial chemistry and target-templated in vitro chemistry, to proteomics and DNA research by using bioconjugation reactions. The triazole products are more than just passive linkers; they readily associate with biological targets, through hydrogen-bonding and dipole interactions. The present review will focus mainly on the recent literature for applications of this reaction in the field of medicinal chemistry, in particular on use of the 1,2,3-triazole moiety as pharmacophore.

  7. Analyzing ERK 1/2 signalling and targets.

    Science.gov (United States)

    Brietz, Alexandra; Schuch, Kristin Verena; Wangorsch, Gaby; Lorenz, Kristina; Dandekar, Thomas

    2016-07-19

    The ERK cascade (e.g. Raf-1) protects the heart from cell death and ischemic injury but can also turn maladaptive. Furthermore, an additional autophosphorylation of ERK2 at Thr188 (Erk1 at Thr208) allows ERK to phosphorylate nuclear targets involved in hypertrophy, stressing this additional phosphorylation as a promising pharmacological target. An in silico model was assembled and setup to reproduce different phosphorylation states of ERK 1/2 and various types of stimuli (hypertrophic versus non-hypertrophic). Synergistic and antagonistic receptor stimuli can be predicted in a semi-quantitative model, simulated time courses were experimentally validated. Furthermore, we detected new targets of ERK 1/2, which possibly contribute to the development of pathological hypertrophy. In addition we modeled further interaction partners involved in the protective and maladaptive cascade. Experimental validation included different gene expression data sets supporting key components and novel interaction partners as well as time courses in chronic heart failure.

  8. Fractals with Hyperbolic Scators in 1 + 2 Dimensions

    Science.gov (United States)

    Fernández-Guasti, M.

    2015-04-01

    A nondistributive scator algebra in 1 + 2 dimensions is used to map the quadratic iteration. The hyperbolic numbers square bound set reveals a rich structure when taken into the three-dimensional (3D) hyperbolic scator space. Self-similar small copies of the larger set are obtained along the real axis. These self-similar sets are located at the same positions and have equivalent relative sizes as the small M-set copies found between the Myrberg-Feigenbaum (MF) point and -2 in the complex Mandelbrot set. Furthermore, these small copies are self similar 3D copies of the larger 3D bound set. The real roots of the respective polynomials exhibit basins of attraction in a 3D space. Slices of the 3D confined scator set, labeled {c2i0}{E}+1+2(s;x,y), are shown at different planes to give an approximate idea of the 3D objects highly complicated boundary.

  9. Synthesis and Conformation of cis-1,2-Disubstituted Cyclododecene

    Institute of Scientific and Technical Information of China (English)

    HAN,Xiang-Yu(韩翔宇); WANG,Ming-An(王明安); LIANG,Xiao-Mei(梁晓梅); WANG,Dao-Quan(王道全)

    2004-01-01

    Eight 1,2-disubstituted cyclododecenes were synthesized from a-alkoxycarbonyl-cyclododecanone and alkyl chloroformate. Their configuration and conformation determined by IR, NMR spectroscopy and X-ray diftraction analysis showed that the carbon-carbon double bond of all of the synthesized compounds has cis-configuration, and the ring skeleton of their preferred conformation is [lene2333] in solid, and they may adopt two different [lene2333]conformations, which exist in a dynamic equilibrium in solution.

  10. Studies of the Beetle 1.2 Pipeline Homogeneity

    CERN Document Server

    Agari, M; Blouw, J; Schmelling, M; Hofmann, W; Schwingenheuer, B; Pugatch, V; Volyanskyy, D; Jiménez-Otero, S; Tran, M T; Voss, H; Bernhard, R P; Köstner, S; Lehner, F; Lois, C; Needham, M; Steinkamp, O; Straumann, U; Vollhardt, A

    2003-01-01

    The pipeline homogeneity in general and the behaviour of the edge channels of the Beetle 1.2 readout chip [1] were studied with data taken during the Silicon Tracker test beam period in May 2003. A contribution of roughly 10\\% from pipeline inhomogeneities to the strip noise was observed. All channels including the first and the last one were found to be fully functional.

  11. General synthesis of substituted 1,2-dihydropyridines.

    Science.gov (United States)

    Tejedor, David; Cotos, Leandro; Méndez-Abt, Gabriela; García-Tellado, Fernando

    2014-11-07

    A general and practical metal-free protocol for the synthesis of 1,2-dihydropyridines with wide structural/functional diversity at the ring and featuring mono, double, or spiro substitution at the sp(3) position is described. The protocol entails a microwave-assisted domino reaction of a propargyl vinyl ether (secondary or tertiary) and a primary amine (aliphatic or aromatic) in toluene or methanol.

  12. Wheeler-Feynman dynamics of spin-1/2 particles

    Energy Technology Data Exchange (ETDEWEB)

    Van Alstine, P.; Crater, H.W.

    1986-02-15

    By combining a supersymmetric description of a spinning particle in an external field with an appropriate modification of the ''adjunct field'' of Wheeler and Feynman, we construct a many-time relativistic dynamics for arbitrary numbers of spin-(1/2) and spinless particles in mutual scalar or vector interaction. Quantization of the slow-motion approximation to the dynamics of two spinning particles reproduces the corresponding field-theoretic (Bethe-Salpeter) dynamics through order U.

  13. Wheeler-Feynman dynamics of spin-1/2 particles

    Science.gov (United States)

    van Alstine, Peter; Crater, Horace W.

    1986-02-01

    By combining a supersymmetric description of a spinning particle in an external field with an appropriate modification of the ``adjunct field'' of Wheeler and Feynman, we construct a many-time relativistic dynamics for arbitrary numbers of spin-(1/2) and spinless particles in mutual scalar or vector interaction. Quantization of the slow-motion approximation to the dynamics of two spinning particles reproduces the corresponding field-theoretic (Bethe-Salpeter) dynamics through order α4.

  14. CMMI (Trademark) for Acquisition, Version 1.2

    Science.gov (United States)

    2007-11-01

    or established technologies to be applied, such as robotics, composite materials, or artificial intelligence ; and breadth of the functionality...you to align the way you do busines They allow you to address scalability and provide a way to incorpora knowledge of how to do things better. Processes...part by the selections made by the organization to meet its busine objectives. Tying It All Together 38 CMMI for Acquisition Version 1.2 4

  15. Synthesis of a Chain Aluminophosphate Containing Racemic 1, 2-Diaminopropane

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    A one-dimensional chain aluminophosphate C1.5H7.5N1.5Al0.5PO4 containing diprotonated racemic 1, 2-diaminopropane cations was synthesized from an alcoholic system. The compound consists of infinite inorganic [AlP2O8] chains of alternately connected AlO4 and PO2(=O)2 tetrahedral units and the racemic template molecules. The macroanionic chains contain corner-shared double four-membered rings.

  16. Hydrophilic nanoporous polystyrenes and 1,2-polybutadienes

    DEFF Research Database (Denmark)

    Guo, Fengxiao; Jankova Atanasova, Katja; Vigild, Martin Etchells;

    2008-01-01

    Nanoporous polymers from ordered block copolymers having hydrophilic cavity surfaces were successfully prepared by two methodologies: ' 1. Nanoporous polystyrenes fromPtBA-b-PS diblock or PDMS-b-PtBA-b-PS triblock copolymer precursors by atom transfer radical polymerization (ATRP), or combination...... different pathways for the conversion of the double bonds of 1,2-PB to bromoisobutyrate by using one to three steps chemical modification. Grafting polyacrylate layers of PPEGMA, PHEMA etc. onto themon...

  17. James Lee Byars 1/2 an autobiography, sourcebook

    CERN Document Server

    Byars, James Lee; Eleey, Peter

    2014-01-01

    "I see my autobiography as an arbitrary segment of so many pages of time, of things that I have paid attention to at this point in my life," wrote James Lee Byars (1932-1997) in 1969. He was then 37, about half the average male lifespan at the time, and accordingly thought it appropriate to write his "1/2 autobiography." Byars' art ranged from highly refined objects to extremely minimal performance and events, and books, ephemera and correspondence that he distributed widely among friends and colleagues. Today, more than 15 years after his death, assessments of his art must negotiate Byars' performance of his charismatic self in his life and art. For his first major posthumous survey in the US, exhibition curators Magalí Arriola and Peter Eleey decided to produce a catalogue in two "halves," playing on his "1/2 autobiography": a catalogue of the exhibition itself, including new scholarship, and a sourcebook of primary documents. 1/2 an Autobiography, Sourcebook constitutes the latter volume--a reference guid...

  18. Bipartite entanglement in spin-1/2Heisenberg model

    Institute of Scientific and Technical Information of China (English)

    HU Ming-Liang; TIAN Dong-Ping

    2008-01-01

    The bipartite entanglement of the two-and three-spin Heisenberg model was investigated by using the concept of negativity.It is found that for the ground-state entanglement of the two-spin model,the negativity always decreases as B increases if A Δ<y-1,and it may keep a steady value of 0.5in the region of B<J[(Δ+1)2-y2]1/2if Δ>y-1,while for that of the three-spin model,the negativity exhibits square wave structures if y=0 or Δ=0.For thermal states,there are two areas showing entanglement,namely,the main region and the sub-region.The main region exists only when Δ>Δc(Δc1=and(y2-1)/2for the 2-and 3-spin model respectively)and extends in terms of B and T as Δ increases,while the sub-region survives only when y≠0 and shrinks in terms of B and T as Δ increases.

  19. Isomerization and fragmentation pathways of 1,2-azaborine.

    Science.gov (United States)

    Edel, Klara; Fink, Reinhold F; Bettinger, Holger F

    2016-01-05

    The generation of 1,2-azaborine (4), the BN-analogue of ortho-benzyne, was recently achieved by elimination of tert-butyldimethylchlorosilane under the conditions of flash vacuum pyrolysis. The present investigation identifies by computational means pathways for the thermal isomerization and fragmentation of 1,2-azaborine. The computations were performed using single reference (hybrid/density functional, second order Møller-Plesset perturbation, and coupled cluster theories) as well as multiconfiguration methods (complete active space SCF based second order perturbation theory, multireference configuration interaction, and multiconfiguration coupled electron pair approximation) with basis sets up to polarized triple-ζ quality. The 1,2-azaborine is, despite the distortion of its molecular structure, the most stable C4H4BN isomer investigated. The formation of BN-endiyne isomers is highly unfavorable as the identified pathways involve barriers close to 80 kcal mol(-1). The concerted fragmentation to ethyne and 2-aza-3-bora-butadiyne even has a barrier close to 120 kcal mol(-1). The fragmentation of BN-enediynes has energetic requirements similar to enediynes. © 2015 Wiley Periodicals, Inc.

  20. 1,2-dicarbonyl compounds in commonly consumed foods.

    Science.gov (United States)

    Degen, Julia; Hellwig, Michael; Henle, Thomas

    2012-07-18

    1,2-Dicarbonyl compounds, formed from carbohydrates during thermal processing in the course of caramelization and Maillard reactions, are intensively discussed as precursors for advanced glycation endproducts in foods and in vivo. To obtain information about the uptake of individual compounds with commonly consumed foods, a comprehensive analysis of the content of 3-deoxyglucosone (3-DG), 3-deoxygalactosone (3-DGal), and methylglyoxal (MGO) together with 5-hydroxymethylfurfural (HMF) in 173 food items like bakery products, pasta, nonalcoholic and alcoholic beverages, sweet spreads, and condiments was performed. Following suitable cleanup procedures, 1,2-dicarbonyl compounds were quantitated after derivatization with o-phenylenediamine via RP-HPLC with UV detection. 3-DG proved to be the predominant 1,2-dicarbonyl compound with concentrations up to 410 mg/L in fruit juices, 2622 mg/L in balsamic vinegars, and 385 mg/kg in cookies, thus exceeding the corresponding concentrations of HMF. 3-DGal was found to be of relevance in many foods even in the absence of galactose. MGO was only of minor quantitative importance in all foods studied, except for manuka honey. Dietary intake was estimated to range between 20 and 160 mg/day for 3-DG and 5 and 20 mg/day for MGO, respectively.

  1. Bis(μ-3-carboxy-2-hydroxypropane-1,2-dicarboxylatobis(diaquazinc–1,2-bis(pyridin-4-ylethene–water (1/1/2

    Directory of Open Access Journals (Sweden)

    In Hong Hwang

    2012-10-01

    Full Text Available The asymmetric unit of the title compound, [Zn2(C6H6O72(H2O4]·C12H10N2·2H2O, comprises half of a centrosymmetric complex dimer, half of a 1,2-bis(pyridin-4-ylethene molecule, which lies across an inversion centre, and one lattice water molecule. Carboxylate groups of two dianionic citrate ligands bridge two ZnII ions to give the cyclic dimer, with each ZnII ion coordinated by four O atoms from the chelating citrate ligand (one hydroxy and three carboxylate, with one bridging and two water O atoms, forming a distorted octahedral environment [Zn—O = 2.040 (3–2.244 (3 Å]. In the crystal, O—H...O and O—H...N hydrogen bonds involving hydroxy groups and both coordinating and lattice water molecules link the dimers to give a three-dimensional framework structure.

  2. Electrical and magnetic properties of (BiNa)1/2(FeV)1/2O3

    Indian Academy of Sciences (India)

    S K Bera; Subrat K Barik; R N P Choudhary; P K Bajpai

    2012-02-01

    Potential multiferroic material, (BiNa)1/2(FeV)1/2O3, synthesized using solid-state route is investigated. The phase formation was confirmed by X-ray diffraction and surface morphology by scanning electron microscopy (SEM). Structural data reveal the single phase formation corroborated by SEM. The grain distribution is uniform with an average grain size of 3.6 m. Electrical properties were investigated in a frequency range (1 kHz–1 MHz) by complex impedance spectroscopy (CIS) technique. The material showed negative temperature coefficient of resistance (NTCR) reflecting semiconductor behaviour. A.C. conductivity was found to obey Johnscher’s law. Conductivity mechanism is discussed and activation energy estimated (1.17 eV) for the conduction process is associated with Fe3+ → Fe2+ variable state. The M–H curve showed the presence of ferromagnetism in the studied material.

  3. The electrical properties and relaxation behavior of AgNb1/2Ta1/2O3 ceramic

    Science.gov (United States)

    Prasad, K. Ganga; Niranjan, Manish K.; Asthana, Saket

    2017-02-01

    Polycrystalline AgNb1/2Ta1/2O3 powder was prepared by solid state reaction method. Preliminary x-ray diffractogram analysis of some aspects of crystal structure showed that a single phase compound formed exhibiting a monoclinic system. Impedance spectroscopy showed the presence of both bulk and grain boundary effects in the material. The relaxation behavior was studied by fitting electric modulus with Bergman function confirms us the existence of non-Debye type of relaxation the material. The ac conductivity spectrum obeyed Funke's double power law and fitting in results, the hopping parameters n1,n2 were indicating the existence of small and large range polaron hopping in the material. The band gap of the material 3.02 eV measured by using UV visible spectroscopy.

  4. [N,N-Bis(2-aminoethylethane-1,2-diamine](ethane-1,2-diaminenickel(II thiosulfate trihydrate

    Directory of Open Access Journals (Sweden)

    Beatrix Seidlhofer

    2012-02-01

    Full Text Available The title compound, [Ni(C2H8N2(C6H18N4]S2O3·3H2O, was accidentally synthesized under solvothermal conditions applying [Ni(en3]Cl2 (en is ethane-1,2-diamine as the Ni source. The asymmetric unit consists of one discrete [Ni(tren(en]2+ complex [tren is N,N-bis(2-aminoethylethane-1,2-diamine] in which the Ni2+ cation is sixfold coordinated within a slightly distorted octahedron, one thiosulfate anion and three water molecules. In the crystal, the complex cations, anions and water molecules are linked by an intricate hydrogen-bonding network. One C atom of the tren ligand, as well as one O atom of a water molecule, are disordered over two sites and were refined using a split model (occupancy ratios = 0.85:15 and 0.60:0.40, respectively.

  5. QCD corrections to inclusive $\\Delta S=1,2$ transitions

    OpenAIRE

    Jamin, Matthias

    1994-01-01

    The talk summarises a calculation of the two-point functions for $\\Delta S=1$ current-current and QCD-penguin operators, as well as for the $\\Delta S=2$ operator, at the next-to-leading order. The size of the gluonic corrections to current-current operators is large, providing a qualitative understanding of the observed enhancement in $\\Delta I=1/2$ transitions. In the $\\Delta S=2$ sector the QCD corrections are quite moderate ($\\approx -20\\%$). This work has been done in collaboration with A...

  6. Proper Time for Spin 1/2 Particles

    CERN Document Server

    Kudaka, S; Kudaka, Shoju; Matsumoto, Shuichi

    2005-01-01

    We find a quantum mechanical formulation of proper time for spin 1/2 particles within the framework of the Dirac theory. It is shown that the rate of proper time can be represented by an operator called the ` ` tempo operator'', and that the proper time itself be given by the integral of the expectation value of the operator. The tempo operator has some terms involving the Pauli spin matrices, and the evolution of the proper time is influenced by the spin state via these terms. The relation between the tempo operator and the metric tensor is elucidated.

  7. Properties of the Lambda(1670)(1-)/2 resonance.

    Science.gov (United States)

    Manley, D M; Abaev, V V; Allgower, C E; Bekrenev, V; Briscoe, W J; Clajus, M; Comfort, J R; Craig, K; Grosnick, D; Isenhower, D; Knecht, N; Koetke, D D; Kulbardis, A A; Kozlenko, N G; Kruglov, S; Lolos, G; Lopatin, I V; Manweiler, R; Marusić, A; McDonald, S; Nefkens, B M K; Olmsted, J; Papandreou, Z; Peaslee, D C; Phaisangittisakul, N; Prakhov, S; Price, J W; Ramirez, A F; Sadler, M; Shafi, A; Spinka, H; Stanislaus, T D S; Starostin, A; Staudenmaier, H M; Strakovsky, I I; Supek, I; Tippens, W B

    2002-01-07

    Recently the Crystal Ball Collaboration measured precise new data for the near-threshold reaction K(-)p-->etaLambda, which is dominated by formation of the Lambda(1670)1 / 2(-). In this Letter, we present results of a unitary, multichannel analysis that incorporates the new Crystal Ball data. For our preferred fit, we obtain mass M = 1673+/-2 MeV, width Gamma = 23+/-6 MeV, and elasticity x = 0.37+/-0.07. This elasticity is significantly larger than previously recognized. Resonance parameters of our preferred fit are in striking agreement with the quark-model predictions of Koniuk and Isgur.

  8. Preparation of perfluorinated 1,2,4-oxadiazoles

    Science.gov (United States)

    Kratzer, R. H.; Paciorek, K. J. L.; Ito, T. I.; Rosser, R. W. (Inventor)

    1982-01-01

    Fluorinated alkyl or alkylether 1,2,4 oxadiazole compounds are prepared by cyclizing the corresponding alkyl or alkylether imidoyl amidoximes in vacuo or in an inert atmosphere at a temperature within the range of 40 C to 100 C. for a period of 8 to 144 hours in the presence of an acid compound which can accept ammonia to form a salt. The imidoyl amidoximes usable in this process are either polymeric or nonpolymeric. The products, when polymeric, have excellent heat, chemical and solvent resistance.

  9. Properties of the Λ(1670)1/2- Resonance

    Science.gov (United States)

    Manley, D. M.; Abaev, V. V.; Allgower, C. E.; Bekrenev, V.; Briscoe, W. J.; Clajus, M.; Comfort, J. R.; Craig, K.; Grosnick, D.; Isenhower, D.; Knecht, N.; Koetke, D. D.; Kulbardis, A. A.; Kozlenko, N. G.; Kruglov, S.; Lolos, G.; Lopatin, I. V.; Manweiler, R.; Marušić, A.; McDonald, S.; Nefkens, B. M.; Olmsted, J.; Papandreou, Z.; Peaslee, D. C.; Phaisangittisakul, N.; Prakhov, S.; Price, J. W.; Ramirez, A. F.; Sadler, M.; Shafi, A.; Spinka, H.; Stanislaus, T. D.; Starostin, A.; Staudenmaier, H. M.; Strakovsky, I. I.; Supek, I.; Tippens, W. B.

    2002-01-01

    Recently the Crystal Ball Collaboration measured precise new data for the near-threshold reaction K-p-->ηΛ, which is dominated by formation of the Λ(1670)1/2-. In this Letter, we present results of a unitary, multichannel analysis that incorporates the new Crystal Ball data. For our preferred fit, we obtain mass M = 1673+/-2 MeV, width Γ = 23+/-6 MeV, and elasticity x = 0.37+/-0.07. This elasticity is significantly larger than previously recognized. Resonance parameters of our preferred fit are in striking agreement with the quark-model predictions of Koniuk and Isgur.

  10. Rectangular Polyomino Set Weak (1,2)-achievement Games

    CERN Document Server

    Fisher, Edgar

    2010-01-01

    In a polyomino set (1,2)-achievement game the maker and the breaker alternately mark one and two previously unmarked cells respectively. The maker's goal is to mark a set of cells congruent to one of a given set of polyominoes. The breaker tries to prevent the maker from achieving his goal. The teams of polyominoes for which the maker has a winning strategy is determined up to size 4. In set achievement games, it is natural to study infinitely large polyominoes. This enables the construction of super winners that characterize all winning teams up to a certain size.

  11. Recent advances bioactive 1,2,4-triazole-3-thiones.

    Science.gov (United States)

    Küçükgüzel, Ş Güniz; Çıkla-Süzgün, Pelin

    2015-06-05

    Triazoles are heterocyclic compounds which have a five-membered ring of two carbon atoms and three nitrogen atoms. These structures have been interest in the development of novel compounds with anticonvulsant, antidepressant, antioxidant, anti-inflammatory, analgesic, antinociceptive, antibacterial, antimycobacterial, antifungal, antiviral, anticancer, anti-parasitic, anti-urease and other activities. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. This review contains various pharmacological activities of 1,2,4-triazole-3-thiones in one place and it is also the milestone for the new research towards this moiety.

  12. Deliverable 1.2.1 Market Analysis and Business Plan

    DEFF Research Database (Denmark)

    Peterson, Carrie Beth

    2009-01-01

    Deliverable 1.2.1 - Market Analysis and Business Plan The main objective of this deliverable is to provide a short overview of 4 communities involved in the pilots, envisaged type of solutions and architectures to be deployed (chapter 2) and market analysis at regional level (chapter 3......) with related business cases. The Market analysis will provide an overview of market requirements, current status and opportunities for the pilot service that will be provided in the context of ISISEMD. This will be realised by performing detailed studies on various sources. Proposals for business modelling...

  13. 反序律B{1,2,i}A{1,2,i}=(AB){1,2,i}i=3,4成立的充要条件%Necessary and sufficient conditions for reverse order laws B{1,2,i}A { 1,2,i} (∈)(AB){1,2,i},i=3,4

    Institute of Scientific and Technical Information of China (English)

    孙萍; 孟令胜

    2011-01-01

    证明两个矩阵乘积的{1,2,3}-逆和{1,2,4}-逆反序律包含关系B{1,2,i}A{1,2,i}(∈)(AB){1,2,i},i=3,4分别等价干等式反序律B{1,2,i}A{1,2,i}=(AB){1,2,i},i=3,4.从而得到上述等式反序律成立的充要条件.%It was verified that the inclusion relationship B{1,2,i}A{1,2,i} (∈)(AB){1,2,i}, i= 3,4 for reverse order laws of {1,2,3}-inverse and {1,2,4}- inverse of the product of two matrixes was respectively equivalent to the identical reverse order laws B{1,2,i}A{1,2,i}=(AB){1,2,i}, i=3,4, so that the necessary and sufficient conditions were obtained for holding the foregoing identical reverse order laws.

  14. Pharmacokinetics of Malonato (1,2 diaminocyclohexane) platinum.

    Science.gov (United States)

    Kelsen, D P; Ribaud, P; Alcock, N; Burchenal, J H; Young, C W; Mathe, G

    1981-01-01

    Malonato-(1,2 diaminocyclohexane) platinum (MP) is a new platinum analog currently undergoing phase I clinical trials. Using flameless atomic absorption spectrophotometry, the pharmacokinetics of MP were studied at five dosage levels. The drug was given as a prolonged intravenous infusion, lasting from 6 to 24 hours. Peak plasma platinum concentrations (Pt) were seen at the end of the infusion, and ranged from 1.1 microgram/ml when 3 mg/kg was given to 14-20.5 micrograms/ml at the 24-mg/kg level. Following completion of the infusion, a prolonged T1/2 beta (mean 63.5 hours) was noted. The percentage of free:total platinum was high (90-95%) at the beginning of the infusion but fell rapidly, to only 15-21% at the end of the 24-hour infusions. Urinary excretion accounted for 16-37.5% of the total administered dose. MP appears to have several pharmacokinetic features in common with cisplatin: rapid binding to protein, a prolonged terminal phase half-life involving primarily bound platinum, and incomplete excretion by the kidney.

  15. LBNF 1.2 MW TARGET: CONCEPTUAL DESIGN & FABRICATION

    Energy Technology Data Exchange (ETDEWEB)

    Crowley, Cory F. [Fermilab; Ammigan, K. [Fermilab; Anderson, K. [Fermilab; Hartsell, B. [Fermilab; Hurh, P. [Fermilab; Hylen, J. [Fermilab; Zwaska, R. [Fermilab

    2015-06-29

    Fermilab’s Long-Baseline Neutrino Facility (LBNF) will utilize a modified design based on the NuMI low energy target that is reconfigured to accommodate beam operation at 1.2 MW. Achieving this power with a graphite target material and ancillary systems originally rated for 400 kW requires several design changes and R&D efforts related to material bonding and electrical isolation. Target cooling, structural design, and fabrication techniques must address higher stresses and heat loads that will be present during 1.2 MW operation, as the assembly will be subject to cyclic loads and thermal expansion. Mitigations must be balanced against compromises in neutrino yield. Beam monitoring and subsystem instrumentation will be updated and added to ensure confidence in target positioning and monitoring. Remote connection to the target hall support structure must provide for the eventual upgrade to a 2.4 MW target design, without producing excessive radioactive waste or unreasonable exposure to technicians during reconfiguration. Current designs and assembly layouts will be presented, in addition to current findings on processes and possibilities for prototype and final assembly fabrication.

  16. Enthalpy and Heat Capacity Data for 1,2-Cyclohexanediol

    Institute of Scientific and Technical Information of China (English)

    周彩荣; 章亚东; 蒋登高

    2003-01-01

    The thermodynamic properties of different geometric structures of 1,2-cyclohexanediol which were rarely reported in literature, such as combustion enthalpy, formation enthalpy, melting enthalpy and heat capacities, were determined by NETZSCH DSC 204 Scanning Calorimeter. The relationship between the melting point and the composition for the mixture system of cis-l,2-cyclohexanediol and trans-l,2-cyclohexanediol was investigated and corresponding phase diagram was obtained. "The melting enthalpies of both cis-l,2-cyclohexanediol and trans-l,2-cyclohexanediol are 20.265 kJ·mo1-1 and 16.368 kJ·mo1-1 respectively. The standard combustion enthalpies of cis- and trans-l,2-cyclohexaneddiol were determined by calorimeter. They are respectively -3507.043kJ·mo1-1 and -3497.8kJ·mo1-1 at 298.15 K.The standard formation enthalpies are respectively 568.997kJ·mol-1 and 578.240kJ·mol-1 for cis- and trans-1,2-cyclohexaneddiol.

  17. Banana-shaped 1,2,4-oxadiazoles

    Indian Academy of Sciences (India)

    S I Torgova; T A Geivandova; O Francescangeli; A Strigazzi

    2003-08-01

    3,5-Disubstituted 1,2,4-oxadiazoles are a new type of liquid crystalline (LC) compounds with asymmetrical five-membered heterocycle as a central unit. They have a bent shape and are very convenient model-compounds for studying the dependence of the LC properties on the molecular design. We have also synthesized and investigated ‘banana-shaped’ 1,2,4-oxadiazoles using the ester groups as the linkage units. The new compounds exhibit spontaneous polarization in the smectic phase, even if there is no chiral group in the molecules. Preliminary experimental data suggest the presence of spontaneous polarization in the nematic phase as well. In order to study the structural properties of the LC phases, X-ray diffraction (XRD) measurements on powder samples have been carried out. Based on the XRD data, a model of the structural arrangement of the bent molecules in the smectic phase is provided, which accounts for the macroscopic spontaneous polarization as well as the ferroelectric switching behavior.

  18. (1RS,2RS,3RS-1,2-Dimethoxy-3-methyl-2-phenyl-1-(2-thienylcyclopropane

    Directory of Open Access Journals (Sweden)

    Laura Torre-Fernández

    2009-04-01

    Full Text Available In the title compound, C16H18O2S, a new cis-1,2-dimethoxycyclopropane, the two methoxy groups are in a cis configuration and in trans positions with respect to the H atom and the phenyl and thienyl rings on the cyclopropyl group. The molecular packing is dominated by weak intermolecular C—H...O interactions, allowing the formation of zigzag chains propagating parallel to the c axis. The dihedral angle between the aromatic rings is 86.12 (8°.

  19. Fabry-Perot Observations of HH 1/2

    Directory of Open Access Journals (Sweden)

    A. Riera

    2005-01-01

    Full Text Available Presentamos nuevas observaciones Fabry-Perot del sistema HH1/2 en la l nea de H. Se han obtenidos los perfiles de las l neas, y los mapas de velocidad radial y de dispersi n de velocidades a partir de los canales de velocidad de los objetos HH 1 y HH 2. La distribuci on espacial de la velocidad radial de ambos objetos (HH 1, HH 2 presenta material desplazado al rojo hacia la fuente, y material desplazado al azul alej ndose de la fuente. Un modelo que contempla la presencia de emisi n directa+dispersada con tres condensaciones emisoras reproduce cualitativamente la distribuci n espacial de la velocidad radial y de la dispersi n de velocidades de HH 2.

  20. Enzymatic Macrocyclization of 1,2,3-Triazole Peptide Mimetics.

    Science.gov (United States)

    Oueis, Emilia; Jaspars, Marcel; Westwood, Nicholas J; Naismith, James H

    2016-05-04

    The macrocyclization of linear peptides is very often accompanied by significant improvements in their stability and biological activity. Many strategies are available for their chemical macrocyclization, however, enzyme-mediated methods remain of great interest in terms of synthetic utility. To date, known macrocyclization enzymes have been shown to be active on both peptide and protein substrates. Here we show that the macrocyclization enzyme of the cyanobactin family, PatGmac, is capable of macrocyclizing substrates with one, two, or three 1,4-substituted 1,2,3-triazole moieties. The introduction of non-peptidic scaffolds into macrocycles is highly desirable in tuning the activity and physical properties of peptidic macrocycles. We have isolated and fully characterized nine non-natural triazole-containing cyclic peptides, a further ten molecules are also synthesized. PatGmac has now been shown to be an effective and versatile tool for the ring closure by peptide bond formation.

  1. sl(1|2) Super-Toda Fields

    Institute of Scientific and Technical Information of China (English)

    YANG Zhan-Ying; XUE Pan-Pan; ZHAO Liu; SHI Kang-Jie

    2008-01-01

    Explicit exact solution of supersymmetric Toda fields associated with the Lie superalgebra sr(2|1) is con-structed. The approach used is a super extension of Leznov-Saveliev algebraic analysis, which is based on a pair of chiral and antichiral Drienfeld-Sokolov systems. Though such approach is well understood for Toda field theories associated with ordinary Lie algebras, its super analogue was only successful in the super Liouville case with the underlying Lie superalgebra osp(1|2). The problem lies in that a key step in the construction makes use of the tensor product decom-position of the highest weight representations of the underlying Lie superalgebra, which is not clear until recently. So our construction made in this paper presents a first explicit example of Leznov-Saveliev analysis for super Toda systems associated with underlying Lie superalgebras of the rank higher than 1.

  2. Deliverable 1.2.1 Market Analysis and Business Plan

    DEFF Research Database (Denmark)

    Peterson, Carrie Beth

    2009-01-01

    Deliverable 1.2.1 - Market Analysis and Business Plan The main objective of this deliverable is to provide a short overview of 4 communities involved in the pilots, envisaged type of solutions and architectures to be deployed (chapter 2) and market analysis at regional level (chapter 3......) with related business cases. The Market analysis will provide an overview of market requirements, current status and opportunities for the pilot service that will be provided in the context of ISISEMD. This will be realised by performing detailed studies on various sources. Proposals for business modelling...... and business cases (chapter 4) will rely on the concept of value chains. Value chains typically consist of several providers, which together produce a complex product or service....

  3. Conformation of 1,2-Dimethoxyethane in Water

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    To understand the conformation of 1,2-dimethoxyethane (DME) in water, a system of two kinds of molecules, DME and H2O, was focused. The interaction of various conformers of DME with water was studied by means of ab initio molecular orbital calculation with 6-31G(d)basis set. It is shown that there are two forms of interactions between the two molecules in the sys tem, the close touched (H2O attaches to the two oxygen atoms of DME) and the open touched (H2O attaches to one oxygen atom of DME) structures. The conformation of DME is remark ably influenced by the interactions. Instead the ttt conformer is preferred in the gas state, with a close touched H2O the tgt conformer becomes the most stable one. The obtained hydration ener gies show that the stabilized order of DME conformers by water is tgt>tgg'>ttt.

  4. Vacuum polarization in $d+{1/2}$ dimensions

    CERN Document Server

    Fosco, C D; Roditi, I

    2004-01-01

    We study the main properties of the one-loop vacuum polarization function ($\\Pi_{\\alpha \\beta}$) for spinor $QED$ in `$d + {1/2}$ dimensions', i.e., with fields defined on ${\\mathcal M} \\subset {\\mathbb R}^{d+1}$ such that ${\\mathcal M} = \\{(x_0,...,x_d) | x_{d}\\geq 0 \\}$, with bag-like boundary conditions on the boundary $\\partial{\\mathcal M} = \\{(x_0,...,x_d) | x_{d}= 0 \\}$. We obtain an exact expression for the induced current due to an external constant electric field normal to the boundary. We show that, for the particular case of 2+1 dimensions, there is a transverse component for the induced current, which is localized on a region close to $\\partial{\\mathcal M}$. This current is a parity breaking effect purely due to the boundary.

  5. Generalized Spin-1/2 Operators and their Eigenvectors

    CERN Document Server

    Mweene, H V

    1999-01-01

    Recently, we have shown how the interpretation of quantum mechanics due to Lande' can be used to derive from first principles generalized formulas for the operators and some eigenvectors for spin 1/2. Though we gave the operators for all the components of the spin, we did not give the eigenvectors of the operators for the x and y components. We now give these eigenvectors. In addition, we present a new and simple method for deriving the operators for the x and y components of the spin as well as their eigenvectors from the corresponding quantities for the z component. We give a general proof that the operator for the square of the spin is the unit matrix multiplied by the value of the square of the spin.

  6. Synthesis and Antimicrobial Activity of 1,2-Benzothiazine Derivatives

    Directory of Open Access Journals (Sweden)

    Chandani Patel

    2016-06-01

    Full Text Available A number of 1,2-benzothiazines have been synthesized in a three-step process. Nine chalcones 1–9 bearing methyl, fluoro, chloro and bromo substituents were chlorosulfonated with chlorosulfonic acid to generate the chalcone sulfonyl chlorides 10–18. These were converted to the dibromo compounds 19–27 through reaction with bromine in glacial acetic acid. Compounds 19–27 were reacted with ammonia, methylamine, ethylamine, aniline and benzylamine to generate a library of 45 1,2-benzothiazines 28–72. Compounds 28–72 were evaluated for their antimicrobial activity using broth microdilution techniques against two Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus and two Gram-negative bacteria (Proteus vulgaris and Salmonella typhimurium. The results demonstrated that none of the compounds showed any activity against Gram-negative bacteria P. vulgaris and S. typhimurium; however, compounds 31, 33, 38, 43, 45, 50, 53, 55, 58, 60, 63 and 68 showed activity against Gram-positive bacteria Bacillus subtilis and Staphylococcous aureus. The range of minimum inhibitory concentration (MIC and minimum bactericidal concentration (MBC was 25–600 µg/mL, though some of the MIC and MBC concentrations were high, indicating weak activity. Structure activity relationship studies revealed that the compounds with a hydrogen atom or an ethyl group on the nitrogen of the thiazine ring exerted antibacterial activity against Gram-positive bacteria. The results also showed that the compounds where the benzene ring of the benzoyl moiety contained a methyl group or a chlorine or bromine atom in the para position showed higher antimicrobial activity. Similar influences were identified where either a bromine or chlorine atom was in the meta position.

  7. Green synthesis and characterization of Ag1/2Al1/2TiO3 nanoceramics

    Directory of Open Access Journals (Sweden)

    Kumar Sandeep

    2015-03-01

    Full Text Available Single phase silver aluminum titanate (Ag1/2Al1/2TiO3, later called AAT, nanoceramic powder (particle size 2 to 7.5 nm was synthesized by a low-cost, green and reproducible tartaric acid gel process. X-ray, FT-IR, energy dispersive X-ray and high resolution transmission electron microscopy analyses were performed to ascertain the formation of AAT nanoceramics. X-ray diffraction data analysis indicated the formation of monoclinic structure having the space group P2/m(10. UV-Vis study revealed the surface plasmon resonance at 296 nm. Dielectric study revealed that AAT nanoceramics could be a suitable candidate for capacitor applications and meets the specifications for “Z7R” of Class I dielectrics of Electronic Industries Association. Complex impedance analyses suggested the dielectric relaxation to be of non-Debye type. To find a correlation between the response of the real system and idealized model circuit composed of discrete electrical components, the model fittings were performed using the impedance data. Electric modulus studies supported the hopping type of conduction in AAT. The correlated barrier hopping model was employed to successfully explain the mechanism of charge transport in AAT. The ac conductivity data were used to evaluate the density of states at Fermi level and minimum hopping length of the compound.

  8. Características de Carcaça e da Carne de Novilhos Filhos de Vacas 1/2 Nelore 1/2 Charolês e 1/2 Charolês 1/2 Nelore Acasaladas com Touros Charolês ou Nelore Carcass and Meat Characteristics of Steers Produced by 1/2 Nellore 1/2 Charolais and 1/2 Charolais 1/2 Nellore Cows Mated with Charolais and Nellore Bulls

    Directory of Open Access Journals (Sweden)

    Fabiano Nunes Vaz

    2002-07-01

    Full Text Available Este experimento foi conduzido com o objetivo de avaliar o efeito do cruzamento entre vacas 1/2 Nelore 1/2 Charolês com touros Charolês e 1/2 Charolês 1/2 Nelore com touros Nelore, sobre as características de carcaça e da carne de novilhos oriundos desses acasalamentos, abatidos aos dois anos de idade. Foram utilizados 80 novilhos 3/4 Nelore (N 1/4 Charolês (C e 136 novilhos 3/4 C 1/4 N. Os dados foram coletados de setembro de 1986 a dezembro de 1998. O modelo estatístico utilizado incluiu os efeitos classificatórios de grupo contemporâneo, idade da vaca e composição racial, bem como o efeito da idade do animal ao abate como covariável. Os novilhos 3/4 C 1/4 N foram superiores em peso de fazenda (468 contra 448 kg, conformação de carcaça (11,3 contra 10,4 pontos, porcentagem de músculo (66,9 contra 64,8%, área de Longissimus dorsi (69,5 contra 64,7 cm², área de Longissimus dorsi ajustada para o peso de carcaça fria (27,9 contra 26,6 cm², comprimento de carcaça (126 contra 123 cm, perímetro de braço (36,5 contra 35,4 cm e maciez da carne (6,50 contra 5,20 pontos, enquanto os 3/4 N 1/4 C apresentaram maiores rendimento de carcaça (54,6 contra 53,7%, comprimento de perna (74,0 contra 72,0 cm e de braço (41,5 contra 39,7 cm, espessura de gordura subcutânea (3,29 contra 2,70 mm e porcentagem de gordura na carcaça (19,5 contra 17,8%. Não foi verificada diferença significativa para peso de carcaça fria, cor, textura, marmoreio, palatabilidade e suculência da carne.The objective of the experiment was to evaluate the carcass and meat characteristics of two year old steers, produced by the mating of 1/2 Nellore 1/2 Charolais cows with Charolais bulls and by mating 1/2 Charolais 1/2 Nellore cows with Nellore bulls. Eighty 3/4 Nellore 1/4 Charolais (NC and 136 3/4 Charolais 1/4 Nellore steers were used. The data were collected from September 1986 to December 1998. In the statistical model were included the contemporary group

  9. Preliminary site description Simpevarp subarea - version 1.2

    Energy Technology Data Exchange (ETDEWEB)

    Winberg, Anders (ed.)

    2005-04-01

    The objectives of the version 1.2 site descriptive modelling (SDM) of the Simpevarp subarea are to produce and document an integrated description of the site and its regional environments based on the site-specific data available from the initial site investigations and to give recommendations on continued investigations on a continuous basis. The modelling work is based on primary data available at the time of the data freeze for Simpevarp 1.2, April 1, 2004. The local scale model area (24 km{sup 2}) for the Simpevarp 1.2 modelling encompasses both the Simpevarp and Laxemar subareas. The local model area is located in the centre of a regional scale model area (273 km{sup 2}). Surface ecosystem models in terms of pools and fluxes of carbon have been developed for the terrestrial (e.g. plants and animals) and limnic (e.g. algae and fish) systems using the Lake Frisksjoen drainage area. Furthermore, a first marine ecosystem model has been developed for the Basin Borholmsfjaerden. Three principal lithological domains have been defined in the subarea, an A domain that is dominated by the Aevroe granite, a domain B that is dominated by the fine-grained dioritoid, a C domain that is characterised by a mixture of of Aevroe granite and quartz monzodiorite. A fourth domain is made up a few scattered domains of diorite to gabbro. In total, 22 deformation zones with high confidence of occurrence have been interpreted in the local scale model area. The understanding of the interpreted deformation zones of the Simpevarp subarea is considered adequate to make a preliminary assessment of available storage volumes for a deep repository. High rock stresses do not appear to be a major concern for the Simpevarp subarea. The magnitude of the maximum principal stress at 500 m in the Simpevarp subarea is estimated at 10-22 MPa. The analysis of the thermal conductivity has developed considerably since Simpevarp 1.1. In terms of interpreted mean values for the identified lithological

  10. Preliminary site description Simpevarp subarea - version 1.2

    Energy Technology Data Exchange (ETDEWEB)

    Winberg, Anders (ed.)

    2005-04-01

    The objectives of the version 1.2 site descriptive modelling (SDM) of the Simpevarp subarea are to produce and document an integrated description of the site and its regional environments based on the site-specific data available from the initial site investigations and to give recommendations on continued investigations on a continuous basis. The modelling work is based on primary data available at the time of the data freeze for Simpevarp 1.2, April 1, 2004. The local scale model area (24 km{sup 2}) for the Simpevarp 1.2 modelling encompasses both the Simpevarp and Laxemar subareas. The local model area is located in the centre of a regional scale model area (273 km{sup 2}). Surface ecosystem models in terms of pools and fluxes of carbon have been developed for the terrestrial (e.g. plants and animals) and limnic (e.g. algae and fish) systems using the Lake Frisksjoen drainage area. Furthermore, a first marine ecosystem model has been developed for the Basin Borholmsfjaerden. Three principal lithological domains have been defined in the subarea, an A domain that is dominated by the Aevroe granite, a domain B that is dominated by the fine-grained dioritoid, a C domain that is characterised by a mixture of of Aevroe granite and quartz monzodiorite. A fourth domain is made up a few scattered domains of diorite to gabbro. In total, 22 deformation zones with high confidence of occurrence have been interpreted in the local scale model area. The understanding of the interpreted deformation zones of the Simpevarp subarea is considered adequate to make a preliminary assessment of available storage volumes for a deep repository. High rock stresses do not appear to be a major concern for the Simpevarp subarea. The magnitude of the maximum principal stress at 500 m in the Simpevarp subarea is estimated at 10-22 MPa. The analysis of the thermal conductivity has developed considerably since Simpevarp 1.1. In terms of interpreted mean values for the identified lithological

  11. [1-(2,5-Dichloroanilino-5-methyl-1H-1,2,3-triazol-4-yl]methanol

    Directory of Open Access Journals (Sweden)

    Anna C. Cunha

    2016-01-01

    Full Text Available In the title compound, C10H10Cl2N4O, the hydroxy group and benzene ring are disposed to opposite sides of the central 1,2,3-triazolyl ring. The dihedral angle between the five- and six-membered rings is 87.51 (12°, and the C—O bond of the hydroxy group lies almost normal to the plane of the 5-membered ring [N—C—C—O = −93.2 (2°]. An intramolecular amino-N—H...Cl hydrogen bond is noted. In the extended structure, supramolecular layers in the ab plane are formed via hydroxy-O—H...N(ring and amine-N—H...O(hydroxy hydrogen bonds. The layers are connected along the c axis by π–π contacts between benzene rings [inter-centroid distance = 3.7789 (13 Å] and by C—Cl...π interactions.

  12. Preliminary site description Forsmark area - version 1.2

    Energy Technology Data Exchange (ETDEWEB)

    Skagius, Kristina (ed.)

    2005-06-01

    The Swedish Nuclear Fuel and Waste Management Company (SKB) is undertaking site characterisation at two different locations, the Forsmark and Simpevarp areas, with the objective of siting a geological repository for spent nuclear fuel. An integrated component in the characterisation work is the development of a site descriptive model that constitutes a description of the site and its regional setting, covering the current state of the geosphere and the biosphere as well as those ongoing natural processes that affect their long-term evolution. The present report documents the site descriptive modelling activities (version 1.2) for the Forsmark area. The overall objectives of the version 1.2 site descriptive modelling are to produce and document an integrated description of the site and its regional environments based on the site-specific data available from the initial site investigations and to give recommendations on continued investigations. The modelling work is based on primary data, i.e. quality-assured, geoscientific and ecological field data available in the SKB databases SICADA and GIS, available July 31, 2004. The work has been conducted by a project group and associated discipline-specific working groups. The members of the project group represent the disciplines of geology, rock mechanics, thermal properties, hydrogeology, hydrogeochemistry, transport properties and surface ecosystems (including overburden, surface hydrogeochemistry and hydrology). In addition, some group members have specific qualifications of importance in this type of project e.g. expertise in RVS (Rock Visualisation System) modelling, GIS-modelling and in statistical data analysis. The overall strategy to achieve a site description is to develop discipline-specific models by interpretation and analyses of the primary data. The different discipline-specific models are then integrated into a site description. Methodologies for developing the discipline-specific models are documented in

  13. Word Criticality Analysis. MOS: 16B. Skill Levels 1 & 2

    Science.gov (United States)

    1981-09-01

    COMMAND FORT MONROE, VIRGINIA 23651 - A-9 1916 A., ’F 41 IIL SEQUJENTIAL CATA AGE 4 A’~~s~ ,~.. ~ AG 1C 2 TYPE MEORO By-. S5 ANC ~,(f A ZA’I’L Y elt *4...il #1 1l, 13. 1)1 1.;, IC , !. 1 !*2,t Ict ’. 9201 96,V1 - 95, 9C92 es.* 64. ,. 6z[*4 ’-.’ !9,1 !6,1. T.1 61o 669. 659. -.,1 %, 55, 56p: 45.1 4, 47.2...4 SliEL 57.1 let! 4 S t - Y-S fE P lot 4 SHV-r 2)01 4 ST i.Z. ).h. 4 ’ I.ACI 7t- 4 S)C’ 1s 1 98.gl 7.1 4 sIrf.. E !#I 141.1 UN3.1 4 sc i C,± ict

  14. Efimov physics with $1/2$ spin-isospin fermions

    CERN Document Server

    Kievsky, A

    2015-01-01

    The structure of few-fermion systems having $1/2$ spin-isospin symmetry is studied using potential models. The strength and range of the two-body potentials are fixed to describe low energy observables in the angular momentum $L=0$ state and spin $S=0,1$ channels of the two-body system. Successively the strength of the potentials are varied in order to explore energy regions in which the two-body scattering lengths are close to the unitary limit. This study is motivated by the fact that in the nuclear system the singlet and triplet scattering lengths are both large with respect to the range of the interaction. Accordingly we expect evidence of universal behavior in the three- and four-nucleon systems that can be observed from the study of correlations between observables. In particular we concentrate in the behavior of the first excited state of the three-nucleon system as the system moves away from the unitary limit. We also analyze the dependence on the range of the three-body force of some low-energy obser...

  15. Efimov Physics with {1/2} Spin-Isospin Fermions

    Science.gov (United States)

    Kievsky, A.; Gattobigio, M.

    2016-03-01

    The structure of few-fermion systems having {1/2} spin-isospin symmetry is studied using potential models. The strength and range of the two-body potentials are fixed to describe low energy observables in the angular momentum {L=0} state and spin {S=0,1} channels of the two-body system. Successively the strength of the potentials are varied in order to explore energy regions in which the two-body scattering lengths are close to the unitary limit. This study is motivated by the fact that in the nuclear system the singlet and triplet scattering lengths are both large with respect to the range of the interaction. Accordingly we expect evidence of universal behavior in the three- and four-nucleon systems that can be observed from the study of correlations between observables. In particular we concentrate in the behavior of the first excited state of the three-nucleon system as the system moves away from the unitary limit. We also analyze the dependence on the range of the three-body force of some low-energy observables in the three- and four-nucleon systems.

  16. The Beetle Reference Manual chip version 1.2

    CERN Document Server

    Baumeister, D; Schmelling, M

    2006-01-01

    This paper details the electrical specifications, operating conditions and port definitions of the readout chip Beetle 1.2. The chip is developed for the LHCb experiment and fulfils the requirements of the silicon vertex detector (VELO, VETO), the silicon tracker and the RICH detector in case of multi-anode photomultiplier readout. It integrates 128 channels with low-noise charge-sensitive preamplifiers and shapers. The pulse shape can be chosen such that it complies with LHCb specifications: a peaking time of 25 ns with a remainder of the peak voltage after 25 ns of less than 30%. A comparator per channel with configurable polarity provides a binary signal. Four adjacent comparator channels are being ORed and brought off chip via LVDS ports. Either the shaper or comparator output is sampled with the LHC-bunch-crossing frequency of 40 MHz into an analog pipeline. This ring buffer has a programmable latency of max. 160 sampling intervals and an integrated derandomising buffer of 16 stages. For analog readout d...

  17. Sparse SAR imaging based on L1/2 regularization

    Institute of Scientific and Technical Information of China (English)

    ZENG JinShan; FANG Jian; XU ZongBen

    2012-01-01

    In this paper,a novel method for synthetic aperture radar (SAR) imaging is proposed.The approach is based on L1/2 regularization to reconstruct the scattering field,which optimizes a quadratic error term of the SAR observation process subject to the interested scene sparsity. Compared to the conventional SAR imaging technique,the new method implements SAR imaging effectively at much lower sampling rate than the Nyquist rate,and produces high-quality images with reduced sidelobes and increased resolution. Also,over the prevalent greedy pursuit and L1 regularization based SAR imaging methods,there are remarkable performance improvements of the new method.On one hand,the new method significantly reduces the number of measurements needed for reconstruction,as supported by a phase transition diagram study.On the other hand,the new method is more robust to the observation noise.These fundamental properties of the new method are supported and demonstrated both by simulations and real SAR data experiments.

  18. RAG1/2 knockout pigs with severe combined immunodeficiency.

    Science.gov (United States)

    Huang, Jiao; Guo, Xiaogang; Fan, Nana; Song, Jun; Zhao, Bentian; Ouyang, Zhen; Liu, Zhaoming; Zhao, Yu; Yan, Quanmei; Yi, Xiaoling; Schambach, Axel; Frampton, Jon; Esteban, Miguel A; Yang, Dongshan; Yang, Huaqiang; Lai, Liangxue

    2014-08-01

    Pigs share many physiological, biochemical, and anatomical similarities with humans and have emerged as valuable large animal models for biomedical research. Considering the advantages in immune system resemblance, suitable size, and longevity for clinical practical and monitoring purpose, SCID pigs bearing dysfunctional RAG could serve as important experimental tools for regenerative medicine, allograft and xenograft transplantation, and reconstitution experiments related to the immune system. In this study, we report the generation and phenotypic characterization of RAG1 and RAG2 knockout pigs using transcription activator-like effector nucleases. Porcine fetal fibroblasts were genetically engineered using transcription activator-like effector nucleases and then used to provide donor nuclei for somatic cell nuclear transfer. We obtained 27 live cloned piglets; among these piglets, 9 were targeted with biallelic mutations in RAG1, 3 were targeted with biallelic mutations in RAG2, and 10 were targeted with a monoallelic mutation in RAG2. Piglets with biallelic mutations in either RAG1 or RAG2 exhibited hypoplasia of immune organs, failed to perform V(D)J rearrangement, and lost mature B and T cells. These immunodeficient RAG1/2 knockout pigs are promising tools for biomedical and translational research.

  19. Orientational relaxations in solid (1,1,2,2)tetrachloroethane

    Science.gov (United States)

    Tripathi, P.; Mitsari, E.; Romanini, M.; Serra, P.; Tamarit, J. Ll.; Zuriaga, M.; Macovez, R.

    2016-04-01

    We employ dielectric spectroscopy and molecular dynamic simulations to investigate the dipolar dynamics in the orientationally disordered solid phase of (1,1,2,2)tetrachloroethane. Three distinct orientational dynamics are observed as separate dielectric loss features, all characterized by a simply activated temperature dependence. The slower process, associated to a glassy transition at 156 ± 1 K, corresponds to a cooperative motion by which each molecule rotates by 180° around the molecular symmetry axis through an intermediate state in which the symmetry axis is oriented roughly orthogonally to the initial and final states. Of the other two dipolar relaxations, the intermediate one is the Johari-Goldstein precursor relaxation of the cooperative dynamics, while the fastest process corresponds to an orientational fluctuation of single molecules into a higher-energy orientation. The Kirkwood correlation factor of the cooperative relaxation is of the order of one tenth, indicating that the molecular dipoles maintain on average a strong antiparallel alignment during their collective motion. These findings show that the combination of dielectric spectroscopy and molecular simulations allows studying in great detail the orientational dynamics in molecular solids.

  20. Resistance integrons: class 1, 2 and 3 integrons.

    Science.gov (United States)

    Deng, Yang; Bao, Xuerui; Ji, Lili; Chen, Lei; Liu, Junyan; Miao, Jian; Chen, Dingqiang; Bian, Huawei; Li, Yanmei; Yu, Guangchao

    2015-10-20

    As recently indiscriminate abuse of existing antibiotics in both clinical and veterinary treatment leads to proliferation of antibiotic resistance in microbes and poses a dilemma for the future treatment of such bacterial infection, antimicrobial resistance has been considered to be one of the currently leading concerns in global public health, and reported to widely spread and extended to a large variety of microorganisms. In China, as one of the currently worst areas for antibiotics abuse, the annual prescription of antibiotics, including both clinical and veterinary treatment, has approaching 140 gram per person and been roughly estimated to be 10 times higher than that in the United Kingdom, which is considered to be a potential area for the emergence of "Super Bugs". Based on the integrons surveillance in Guangzhou, China in the past decade, this review thus aimed at summarizing the role of integrons in the perspective of both clinical setting and environment, with the focus on the occurrence and prevalence of class 1, 2 and 3 integrons.

  1. Urinary prothrombin fragment 1+2 in patients with venous thrombosis and myocardial infarction

    NARCIS (Netherlands)

    Van Es, J.; Biere-Rafi, S.; Ahdi, M.; Kamphuisen, P.W.; Meijers, J.C.M.; Gerdes, V.E.A.

    2013-01-01

    Patients with venous-thromboembolism (VTE) and myocardial infarction (MI) have elevated prothrombin fragment 1+2 (F1+2) levels. In patients with postoperative VTE, urinary F1+2 (uF1+2) was higher than in individuals without VTE. To explore the relationship between plasma and uF1+2 we performed a pil

  2. Vapor intrusion risk of lead scavengers 1,2-dibromoethane (EDB) and 1,2-dichloroethane (DCA).

    Science.gov (United States)

    Ma, Jie; Li, Haiyan; Spiese, Richard; Wilson, John; Yan, Guangxu; Guo, Shaohui

    2016-06-01

    Vapor intrusion of synthetic fuel additives represented a critical yet still neglected problem at sites impacted by petroleum fuel releases. This study used an advanced numerical model to simulate the vapor intrusion risk of lead scavengers 1,2-dibromoethane (ethylene dibromide, EDB) and 1,2-dichloroethane (DCA) under different site conditions. We found that simulated EDB and DCA indoor air concentrations can exceed USEPA screening level (4.7 × 10(-3) μg/m(3) for EDB and 1.1 × 10(-1) μg/m(3) for DCA) if the source concentration is high enough (is still within the concentration range found at leaking UST site). To evaluate the chance that vapor intrusion of EDB might exceed the USEPA screening levels for indoor air, the simulation results were compared to the distribution of EDB at leaking UST sites in the US. If there is no degradation of EDB or only abiotic degradation of EDB, from 15% to 37% of leaking UST sites might exceed the USEPA screening level. This study supports the statements made by USEPA in the Petroleum Vapor Intrusion (PVI) Guidance that the screening criteria for petroleum hydrocarbon may not provide sufficient protectiveness for fuel releases containing EDB and DCA. Based on a thorough literature review, we also compiled previous published data on the EDB and DCA groundwater source concentrations and their degradation rates. These data are valuable in evaluating EDB and DCA vapor intrusion risk. In addition, a set of refined attenuation factors based on site-specific information (e.g., soil types, source depths, and degradation rates) were provided for establishing site-specific screening criteria for EDB and DCA. Overall, this study points out that lead scavengers EDB and DCA may cause vapor intrusion problems. As more field data of EDB and DCA become available, we recommend that USEPA consider including these data in the existing PVI database and possibly revising the PVI Guidance as necessary.

  3. Using R in Taverna: RShell v1.2

    Directory of Open Access Journals (Sweden)

    Breit Timo M

    2009-07-01

    Full Text Available Abstract Background R is the statistical language commonly used by many life scientists in (omics data analysis. At the same time, these complex analyses benefit from a workflow approach, such as used by the open source workflow management system Taverna. However, Taverna had limited support for R, because it supported just a few data types and only a single output. Also, there was no support for graphical output and persistent sessions. Altogether this made using R in Taverna impractical. Findings We have developed an R plugin for Taverna: RShell, which provides R functionality within workflows designed in Taverna. In order to fully support the R language, our RShell plugin directly uses the R interpreter. The RShell plugin consists of a Taverna processor for R scripts and an RShell Session Manager that communicates with the R server. We made the RShell processor highly configurable allowing the user to define multiple inputs and outputs. Also, various data types are supported, such as strings, numeric data and images. To limit data transport between multiple RShell processors, the RShell plugin also supports persistent sessions. Here, we will describe the architecture of RShell and the new features that are introduced in version 1.2, i.e.: i Support for R up to and including R version 2.9; ii Support for persistent sessions to limit data transfer; iii Support for vector graphics output through PDF; ivSyntax highlighting of the R code; v Improved usability through fewer port types. Our new RShell processor is backwards compatible with workflows that use older versions of the RShell processor. We demonstrate the value of the RShell processor by a use-case workflow that maps oligonucleotide probes designed with DNA sequence information from Vega onto the Ensembl genome assembly. Conclusion Our RShell plugin enables Taverna users to employ R scripts within their workflows in a highly configurable way.

  4. [1,2-Bis(diisopropylphosphanylethane-κ2P,P′]dichloridonickel(II–9H-carbazole (1/2

    Directory of Open Access Journals (Sweden)

    Farah Cañavera-Buelvas

    2011-04-01

    Full Text Available In the title compound, [NiCl2(C14H32P2]·2C12H9N, the neutral [Ni(dppeCl2] complex [dppe is 1,2-bis(diisopropylphosphanylethane] consists of a tetracoordinated Ni2+ cation and has a crystallographic twofold axis passing through the metal atom and the mid-point of the CH2—CH2 bond of the dppe ligand. The metal atom shows slight tetrahedral distortion from an ideal square-planar coordination geometry, as reflected in the dihedral angle between NiCl2 and NiP2 planes of 15.32 (2°. The 9H-carbazole ring system is essentially planar (r.m.s. deviation = 0.022 Å. In the crystal packing, there are two symmetry-related 9H-carbazole molecules between two adjacent NiII complexes, with an angle between the carbazole mean planes of ca 77°.

  5. GSM(m,1)(m=1,2)模型的数值解%Numeriacl Solution of GSM (m, 1)(m= 1,2)Model

    Institute of Scientific and Technical Information of China (English)

    吴强; 刘炳琪

    2001-01-01

    The prediction accuracy can be improved by using the spline function to correct the residue of GM (m,1)(m=1,2). Numerical Solution of GSM (m,1)(m=1,2)Modle is given.%本文用样条函数对GM(m,1)(m=1,2)模型的残差序列进行插值拟合,得到GSM(m,1)(m=1,2)模型的数值解.

  6. Influence of 1,2-PB matrix cross-linking on structure and properties of selectively etched 1,2-PB-b-PDMS block copolymers

    DEFF Research Database (Denmark)

    Guo, Fengxiao; Andreasen, Jens Wenzel; Vigild, Martin Etchells

    2007-01-01

    A series of samples with varying cross-linking degree were prepared from the same 1,2-polybutadiene-b-polydimethylsiloxane (1,2-PB-b-PDMS) diblock copolymer precursor. The stability of nanopores generated after PDMS cleaving depends on the cross-linking degree of 1,2-PB. The swelling ratio of the...

  7. Identification of high-risk Listeria monocytogenes serotypes in lineage I (serotype 1/2a, 1/2c, 3a and 3c) using multiplex PCR

    Science.gov (United States)

    Aims: Using molecular subtyping techniques, Listeria monocytogenes is divided into three major phylogenetic lineages, and a multiplex PCR method can differentiate five L. monocytogenes subgroups: 1/2a-3a, 1/2c-3c, 1/2b-3b-7, 4b-4d-4e, and 4a-4c. In the current study, we conducted genome comparison...

  8. Water Security Toolkit User Manual Version 1.2.

    Energy Technology Data Exchange (ETDEWEB)

    Klise, Katherine A.; Siirola, John Daniel; Hart, David; Hart, William Eugene; Phillips, Cynthia Ann; Haxton, Terranna; Murray, Regan; Janke, Robert; Taxon, Thomas; Laird, Carl; Seth, Arpan; Hackebeil, Gabriel; McGee, Shawn; Mann, Angelica

    2014-08-01

    The Water Security Toolkit (WST) is a suite of open source software tools that can be used by water utilities to create response strategies to reduce the impact of contamination in a water distribution network . WST includes hydraulic and water quality modeling software , optimizati on methodologies , and visualization tools to identify: (1) sensor locations to detect contamination, (2) locations in the network in which the contamination was introduced, (3) hydrants to remove contaminated water from the distribution system, (4) locations in the network to inject decontamination agents to inactivate, remove, or destroy contaminants, (5) locations in the network to take grab sample s to help identify the source of contamination and (6) valves to close in order to isolate contaminate d areas of the network. This user manual describes the different components of WST , along w ith examples and case studies. License Notice The Water Security Toolkit (WST) v.1.2 Copyright c 2012 Sandia Corporation. Under the terms of Contract DE-AC04-94AL85000, there is a non-exclusive license for use of this work by or on behalf of the U.S. government. This software is distributed under the Revised BSD License (see below). In addition, WST leverages a variety of third-party software packages, which have separate licensing policies: Acro Revised BSD License argparse Python Software Foundation License Boost Boost Software License Coopr Revised BSD License Coverage BSD License Distribute Python Software Foundation License / Zope Public License EPANET Public Domain EPANET-ERD Revised BSD License EPANET-MSX GNU Lesser General Public License (LGPL) v.3 gcovr Revised BSD License GRASP AT&T Commercial License for noncommercial use; includes randomsample and sideconstraints executable files LZMA SDK Public Domain nose GNU Lesser General Public License (LGPL) v.2.1 ordereddict MIT License pip MIT License PLY BSD License PyEPANET Revised BSD License Pyro MIT License PyUtilib Revised BSD License Py

  9. Review of Whole person healthcare, Volumes 1, 2, & 3 (2007).

    Science.gov (United States)

    Harvey, Richard

    2009-06-01

    Reviews the book, Whole person healthcare, Volumes 1, 2, & 3 by I. A. Serlin, M. A. DiCowden, K. Rockefeller, S. Brown, J. Sonke-Henderson, R. Brandman, and J. Graham-Pole (2007). With the more-than-1,000-page tour de force titled Whole Person Healthcare, Ilene Serlin, current president of the San Francisco Psychological Association, has purposefully edited a three-volume series aimed at humanizing the fields of psychotherapy and health care. Throughout the series, all of the authors carry the message that integrative treatment strategies in psychotherapy and health care are more valuable than reductionist "treat the symptom rather than the person" approaches as a way to humanize patient-client interaction. Whole Person Healthcare persuasively presents the principle reasons for integrating human-centered strategies into psychotherapeutic and health care practices. Volume 1 of the series, Humanizing Healthcare, sets the tone for the other two volumes, providing a conceptual scaffold for framing humanistic and positive psychological theories within an applied health care setting. Volume 2 of the series, Psychology, Spirituality, and Health, focuses on presenting concrete, evidence-based examples of integrative therapeutic techniques such as imagery and visualization, meditation, meaning finding, prayer and psychospiritual practices, yoga, tai chi, and qi gong. Volume 3 of the series, The Arts and Health, provides a critically important contribution to the field because the art therapies are so often forgotten in the world of managed health care. Volume 3 gives evidence-based examples of the valuable contributions of artistic interactions within therapeutic contexts. The collection of readings in Whole Person Healthcare covers a wide spectrum of modern healing approaches, and this series is a must for any practitioner of integrative, holistic therapies. However, there are two practical barriers of note. First is cost: The price is too steep for most readers

  10. Synthesis and antimicrobial activity of chromone-linked 2-pyridone fused with 1,2,4-triazoles, 1,2,4-triazines and 1,2,4-triazepines ring systems

    Energy Technology Data Exchange (ETDEWEB)

    Ali, Tarik El-Sayed; Ibrahim, Magdy Ahmed, E-mail: magdy_ahmed1977@yahoo.co [Ain Shams University, Cairo (Egypt). Faculty of Education. Dept. of Chemistry

    2010-07-01

    Three series of novel fused nitrogen heterocyclic systems such as 1,2,4-triazolo[1,5-a ] pyridines (5-7 and 9), pyrido[1,2-b][1,2,4]triazines (10, 11, 13 and 15), and pyrido[1,2-b][1,2,4]triazepines (17, 18, 20 and 22) linked with a chromone moiety were synthesized from the key intermediate 1,6-diamino-(6-chloro-4-oxo-4H-chromen-3-yl)-2-oxo-1,2-dihydropyridine-3,5- dicarbonitrile (4) with some electrophilic reagents. The structures of the novel compounds were established by elemental analyses and spectral data. All the products were also screened in vitro for their antimicrobial activity. Compounds 7, 9 and 15 showed the highest activities when compared with the reference drugs. (author)

  11. Studies of Electrochemical Catalytic Reduction Reactions of Tetraphenylporphinatocobalt/1,2-Dibromoethane and 1,2-Dichloroethane Systems in Nonaqueous Media

    Institute of Scientific and Technical Information of China (English)

    林祥钦; 刘殿骏; 汪尔康

    1994-01-01

    Electrochemical catalytic reactions of tetraphenylporphmatocobalt were studied in DMF and EtCl2 solutions in the presence of 1,2 dibroraoethane and 1,2-dichloroethane utilizing cyclic voltamme-try, thin-layer electrochemistry, in situ UV-visible spectroelectrochemistry and computer digital simulation methods. Homogeneous rate constants for reactions of electrogenerated Co(Ⅰ)TPP species with 1,2-dibro-moethane and 1,2-dichloroethane were determined as 1. 2×103 and 5 mol-1 · dm3 × s-1, respectively. Neither alkylation nor degradation of CoTPP was observed.

  12. Naised, kes toovad naeratuse näole / Katrin Oja

    Index Scriptorium Estoniae

    Oja, Katrin

    2006-01-01

    Heast teenindusest räägivad Eesti Gaasi juhatuse esimehe assistent, Aasta Sekretär 2005 Tiivi Lind, lounge 8 baaridaam Kadri Kask ja Sampo Panga koolitusspetsialist, Aasta Teenindaja 2006 Aires Rühka. Kommenteerivad nende ülemused - Sampo Panga koolitusosakonna juhataja Külli Meier, Eesti Gaasi juhatuse esimees Aarne Saar ja lounge 8 mänedžer Heinar Õispuu

  13. Naised põllumajanduses = Women in agriculture / Aili Maanso

    Index Scriptorium Estoniae

    Maanso, Aili

    2006-01-01

    2005. a. struktuuriuuringu andmetel oli Eesti ligi 28 000 põllumajanduslikus majapidamises 90 850 hõivatut. Püsitööjõust (peretööjõud ja alalised töötajad) oli mehi 51,1% ja naisi 48,9%, 37% majapidamistest oli naisjuht. Majapidamiste juhid soo ja vanuse järgi. Tabelid

  14. Seksiorjal on Moldova naise nägu / Marje Aksli

    Index Scriptorium Estoniae

    Aksli, Marje

    2005-01-01

    Rahvusvaheliste organisatsioonide raporti kohaselt on Moldova inimsmugeldamise peamine lähtekoht, põhjustena nähakse riigi geograafilist asendit ja vaesust. Lisa: Lääs püüab Moldova naisi aidata. Vt. samas: Inimkaubitseja on "ettevõtlik ja tubli inimene"

  15. McCain valis asemikuks konservatiivse naise / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2008-01-01

    USA vabariiklaste asepresidendikandidaadist Alaska kubernerist Sarah Palinist. Vt. samas: Poliitiline teater on harva olnud nii suurejooneline. USA demokraatide presidendikandidaadi Barack Obama Denveris peetud kõnest

  16. Malle Talveti huvitavad naised / Kärt Hellerma

    Index Scriptorium Estoniae

    Hellerma, Kärt, 1956-

    2006-01-01

    Arvustus: McCullers, Carson. Laulatuse lummas / tõlk. Malle Talvet. Tallinn : Perioodika, 1988. (Loomingu Raamatukogu ; 1988, 3-5) ; Duras, Marguerite. Armuke / tõlk. Malle Talvet. Tallinn : Perioodika, 1988. (Loomingu Raamatukogu ; 1988, 11-12) ; Brookner, Anita. Hotel du Lac / tõlk. Malle Talvet. Tallinn : Perioodika, 1990. (Loomingu Raamatukogu ; 1990, 45-46). Varem ilmunud: Eesti Elu nr. 1 (13), 1. veebruar 1991

  17. Siiri Oviir osales Euroopa Naise valimiskogus / Ramon Loik

    Index Scriptorium Estoniae

    Loik, Ramon

    2004-01-01

    Euroopa Parlamendi liikme Siiri Oviiri osalemisest Rahvusvahelise Euroopa Naiste Assotsiatsiooni (AIPFE) valimiskogus 13. oktoobril 2004, kus nimetati Euroopa Naine 2004 kandidaadiks kreeklanna Aliki Moschi-Gauget

  18. Naised mõrvarite jälil / Kaisa Karu

    Index Scriptorium Estoniae

    Karu, Kaisa

    2010-01-01

    Kanal 2 ekraanil kaks naispeaosalistega krimisarja : uurija Lilly Rush (Kathryn Morris) sarjas "Jahtunud jälg" (USA, 2003-... ) ja Brenda Leigh Johnson (Kyra Sedgwick) seriaalis "Vahelevõtja" (USA, 2005-... )

  19. Salapärased Iraani naised / Annika Koppel

    Index Scriptorium Estoniae

    Koppel, Annika

    2003-01-01

    Artikli autor kohtus Saksamaal Mannheim-Heidelbergi filmifestivalil iraani režissööri Nasser Refaie ja tema abikasa, näitleja Raya Nasiriga. Režissööri film "Eksam" pälvis ühe žürii auhindadest

  20. Naised ja seksfilmid : "Üheksa laulu" / James Thurlow

    Index Scriptorium Estoniae

    Thurlow, James

    2005-01-01

    Mängufilm "Üheksa laulu" ("9 Songs") : stsenarist ja režissöör Michael Winterbottom : Suurbritannia 2004. Paralleele ka teiste seksiteemale keskendunud mängufilmidega (C. Breillat' "Romanss" jt)

  1. Naised, memoria ja sakraalruum hiliskeskaegsel Liivimaal / Anu Mänd

    Index Scriptorium Estoniae

    Mänd, Anu, 1968-

    2012-01-01

    Gildiõdedest ja nende mälestamisest. Vikaariate rajamisest. Tallinlannade testamentidest ja testaatorite sotsiaalsest taustast. Sakraalruumi kujundavatest annetustest naiste testamentides. Abielupaaride ja naiste annetatud armulauanõudest. Gertrud Wrangeli memoriaalkompleksist. Matusepaikadest ja hauakividest

  2. Hiina naise lugu võitis Kuldkaru / Annika Koppel

    Index Scriptorium Estoniae

    Koppel, Annika

    2007-01-01

    57. Berliini filmifestivali peaauhind Kuldkaru - hiina režissööri Wang Quanani film "Tuya abielu" ("Tuya de hun shi"), parima režissööri Hõbekaru - iisraellane Joseph Cedar ("Beafort"), parim meesnäitleja - Julio Chavez (Ariel Rotteri "Teine"), parim naisnäitleja - Nina Hossa (Christian Petzoldi "Yella"), väljapaistev kunstiline saavutus - Robert De Niro lavastajatöö ("Hea karjane")

  3. Naised mõrvarite jälil / Kaisa Karu

    Index Scriptorium Estoniae

    Karu, Kaisa

    2010-01-01

    Kanal 2 ekraanil kaks naispeaosalistega krimisarja : uurija Lilly Rush (Kathryn Morris) sarjas "Jahtunud jälg" (USA, 2003-... ) ja Brenda Leigh Johnson (Kyra Sedgwick) seriaalis "Vahelevõtja" (USA, 2005-... )

  4. Naised, kes toovad naeratuse näole / Katrin Oja

    Index Scriptorium Estoniae

    Oja, Katrin

    2006-01-01

    Heast teenindusest räägivad Eesti Gaasi juhatuse esimehe assistent, Aasta Sekretär 2005 Tiivi Lind, lounge 8 baaridaam Kadri Kask ja Sampo Panga koolitusspetsialist, Aasta Teenindaja 2006 Aires Rühka. Kommenteerivad nende ülemused - Sampo Panga koolitusosakonna juhataja Külli Meier, Eesti Gaasi juhatuse esimees Aarne Saar ja lounge 8 mänedžer Heinar Õispuu

  5. Naised, kes juhivad mehi / Esme Kassak ; interv. Esme Kassak

    Index Scriptorium Estoniae

    Kassak, Esme

    2008-01-01

    Politseiameti kriminaalosakonna juhataja Krista Aas, Agentuuride Royal Service ja Spring Advertising tegevjuht Rika Soopa, Eesti Päevalehe sporditoimetuse juhataja Kristi Vahemaa, Hansapanga IT infrastruktuuri projektide osakonna juhataja Anna Lizunova, Skype Eesti veebitiimi juht Elina Kostabi valdavalt meestest koosneva kollektiivi juhtimisest. Lisad: Hillary Clinton, Condoleezza Rice, Segolene Royal. Küsimusele, millised on naisjuhtide tugevused, vastavad Mart Mikk, Aavo Kokk, Ants Lusti, Margus Alviste ja Tiit Paananen. Küsimusele, mida arvata mehelikest naistest, vastavad Mart Mikk, Ants Lusti ja Margus Alviste

  6. Naised töömaailmas / Leonora Kraus

    Index Scriptorium Estoniae

    Kraus, Leonora

    2007-01-01

    Saaremaa naiste ümarlaual käsitleti küsimust, kuidas tuua naisi tööturule. Vt. samas ka: Vilma Rauniste. Naiste tööhõivet saab parandada koolituste ja nõustamise kaudu. Artikkel käsitleb Tööturuameti juhi Kaie Lepa ettekannet tööturumeetmete mõjust naiste tööhõivele ja võrdsele kohtlemisele tööturul

  7. Naised, kes juhivad mehi / Esme Kassak ; interv. Esme Kassak

    Index Scriptorium Estoniae

    Kassak, Esme

    2008-01-01

    Politseiameti kriminaalosakonna juhataja Krista Aas, Agentuuride Royal Service ja Spring Advertising tegevjuht Rika Soopa, Eesti Päevalehe sporditoimetuse juhataja Kristi Vahemaa, Hansapanga IT infrastruktuuri projektide osakonna juhataja Anna Lizunova, Skype Eesti veebitiimi juht Elina Kostabi valdavalt meestest koosneva kollektiivi juhtimisest. Lisad: Hillary Clinton, Condoleezza Rice, Segolene Royal. Küsimusele, millised on naisjuhtide tugevused, vastavad Mart Mikk, Aavo Kokk, Ants Lusti, Margus Alviste ja Tiit Paananen. Küsimusele, mida arvata mehelikest naistest, vastavad Mart Mikk, Ants Lusti ja Margus Alviste

  8. Naise võim Bermudas : kubjas kukutati / Allan Espenberg

    Index Scriptorium Estoniae

    Espenberg, Allan

    2003-01-01

    Suurbritanniale kuuluva Bermuda saare parlamendivalimised vallandasid sündmuste ahela, mis võivad muuta asumaa poliitikat. Ametist tagandati peaminister Jennifer Meredith Smith ja uueks peaministriks sai senine tööminister William Alexander Scott

  9. Malle Talveti huvitavad naised / Kärt Hellerma

    Index Scriptorium Estoniae

    Hellerma, Kärt, 1956-

    2006-01-01

    Arvustus: McCullers, Carson. Laulatuse lummas / tõlk. Malle Talvet. Tallinn : Perioodika, 1988. (Loomingu Raamatukogu ; 1988, 3-5) ; Duras, Marguerite. Armuke / tõlk. Malle Talvet. Tallinn : Perioodika, 1988. (Loomingu Raamatukogu ; 1988, 11-12) ; Brookner, Anita. Hotel du Lac / tõlk. Malle Talvet. Tallinn : Perioodika, 1990. (Loomingu Raamatukogu ; 1990, 45-46). Varem ilmunud: Eesti Elu nr. 1 (13), 1. veebruar 1991

  10. Rwandas võtsid võimu naised / Allan Espenberg

    Index Scriptorium Estoniae

    Espenberg, Allan

    2008-01-01

    Septembris toimunud parlamendivalimiste järel sai Aafrikas asuvast Rwandast esimene riik, kus parlamendiliikmete hulgas on rohkem naisi kui mehi. Ka parlamendi alamkoja etteotsa valiti naine - naisõiguslane ja õigusteaduste doktor Rose Mukantabana

  11. Naise võim Bermudas : kubjas kukutati / Allan Espenberg

    Index Scriptorium Estoniae

    Espenberg, Allan

    2003-01-01

    Suurbritanniale kuuluva Bermuda saare parlamendivalimised vallandasid sündmuste ahela, mis võivad muuta asumaa poliitikat. Ametist tagandati peaminister Jennifer Meredith Smith ja uueks peaministriks sai senine tööminister William Alexander Scott

  12. Romaanivõistlus 2008 - naised ruulivad! / Peeter Helme

    Index Scriptorium Estoniae

    Helme, Peeter, 1978-

    2009-01-01

    2008. a. romaanivõistlusel 1. auhinda välja ei antud. 2. auhinna võitis Milvi Martina Piiri romaan "Liblikad janus". 3. auhinna võitjaid oli kaks: Birk Rohelend romaaniga "Minu sõraline sõber" ja Marion Andra "Algolagnia". Ergutusauhinna võitnud romaanid: Liina Lüecke "Sügismüsteerium", Robert Kurvitza "Püha ja õudne lõhn", Robert Randma "Sigaret" ja Helju Petsi "Õnneõiteta sirelid"

  13. Naised leedu kunstnike pilgu läbi

    Index Scriptorium Estoniae

    2002-01-01

    Hansapanga galeriis leedu kaasaegse kunsti näitus "Õppides ja lauldes". Kuraator Kestutis Kuizinas. Osalevad Laura Stasiulyte, Gediminas ja Nomeda Urbonas, Vita Zaman. Videod ja slaidiprogrammid näitavad tõelisi või lavastatud episoode naiste elust tänapäeva Leedus

  14. Inimkatse blondi eesti naise peibutustest Egiptuses / Liivi Shein

    Index Scriptorium Estoniae

    Šein, Liivi

    2006-01-01

    ETVs esilinastus 23. nov. "Eesti lugude" sarjas valminud "1001 öö muinasjutt ehk eesti naiste imelised seiklused Egiptuses" : režissöör Elo Selirand : toimetaja Anne-Mari Neider : operaator Mait Mäekivi : Osakond OÜ 2006

  15. Naised põllumajanduses = Women in agriculture / Aili Maanso

    Index Scriptorium Estoniae

    Maanso, Aili

    2006-01-01

    2005. a. struktuuriuuringu andmetel oli Eesti ligi 28 000 põllumajanduslikus majapidamises 90 850 hõivatut. Püsitööjõust (peretööjõud ja alalised töötajad) oli mehi 51,1% ja naisi 48,9%, 37% majapidamistest oli naisjuht. Majapidamiste juhid soo ja vanuse järgi. Tabelid

  16. Naised mustas, sõjasebimine, elektrivaras, lurjusluuletaja / Kristiina Davidjants

    Index Scriptorium Estoniae

    Davidjants, Kristiina, 1974-

    2010-01-01

    Pimedate Ööde Filmifestivalil "EurAsia" võistlusprogrammi filmidest - Mohamed Al-Daradji'i "Paabeli poeg", Aureliano Amadei "20 sigaretti", Aktan Arym Kubati "Härra Valgus", Tomaš Mašini "Kolm aastaaega põrgus", Arto Haloneni "Printsess"

  17. Hille Palmi naised / Juta Kivimäe

    Index Scriptorium Estoniae

    Kivimäe, Juta, 1952-

    2008-01-01

    Kuni 14. V Vabaduse galeriis avatud Hille Palmi skulptuurinäitusest "Tardunud hetked". Lühidalt eelmistest väljapanekutest: Marje Üksise näitusest "Nõnda ma lähen" ja Malle Leisi maalinäitusest

  18. Naised töömaailmas / Leonora Kraus

    Index Scriptorium Estoniae

    Kraus, Leonora

    2007-01-01

    Saaremaa naiste ümarlaual käsitleti küsimust, kuidas tuua naisi tööturule. Vt. samas ka: Vilma Rauniste. Naiste tööhõivet saab parandada koolituste ja nõustamise kaudu. Artikkel käsitleb Tööturuameti juhi Kaie Lepa ettekannet tööturumeetmete mõjust naiste tööhõivele ja võrdsele kohtlemisele tööturul

  19. Salapärased Iraani naised / Annika Koppel

    Index Scriptorium Estoniae

    Koppel, Annika

    2003-01-01

    Artikli autor kohtus Saksamaal Mannheim-Heidelbergi filmifestivalil iraani režissööri Nasser Refaie ja tema abikasa, näitleja Raya Nasiriga. Režissööri film "Eksam" pälvis ühe žürii auhindadest

  20. Naised, memoria ja sakraalruum hiliskeskaegsel Liivimaal / Anu Mänd

    Index Scriptorium Estoniae

    Mänd, Anu, 1968-

    2012-01-01

    Gildiõdedest ja nende mälestamisest. Vikaariate rajamisest. Tallinlannade testamentidest ja testaatorite sotsiaalsest taustast. Sakraalruumi kujundavatest annetustest naiste testamentides. Abielupaaride ja naiste annetatud armulauanõudest. Gertrud Wrangeli memoriaalkompleksist. Matusepaikadest ja hauakividest

  1. Naised mustas, sõjasebimine, elektrivaras, lurjusluuletaja / Kristiina Davidjants

    Index Scriptorium Estoniae

    Davidjants, Kristiina, 1974-

    2010-01-01

    Pimedate Ööde Filmifestivalil "EurAsia" võistlusprogrammi filmidest - Mohamed Al-Daradji'i "Paabeli poeg", Aureliano Amadei "20 sigaretti", Aktan Arym Kubati "Härra Valgus", Tomaš Mašini "Kolm aastaaega põrgus", Arto Haloneni "Printsess"

  2. Hiina naise lugu võitis Kuldkaru / Annika Koppel

    Index Scriptorium Estoniae

    Koppel, Annika

    2007-01-01

    57. Berliini filmifestivali peaauhind Kuldkaru - hiina režissööri Wang Quanani film "Tuya abielu" ("Tuya de hun shi"), parima režissööri Hõbekaru - iisraellane Joseph Cedar ("Beafort"), parim meesnäitleja - Julio Chavez (Ariel Rotteri "Teine"), parim naisnäitleja - Nina Hossa (Christian Petzoldi "Yella"), väljapaistev kunstiline saavutus - Robert De Niro lavastajatöö ("Hea karjane")

  3. Naised ja seksfilmid : "Üheksa laulu" / James Thurlow

    Index Scriptorium Estoniae

    Thurlow, James

    2005-01-01

    Mängufilm "Üheksa laulu" ("9 Songs") : stsenarist ja režissöör Michael Winterbottom : Suurbritannia 2004. Paralleele ka teiste seksiteemale keskendunud mängufilmidega (C. Breillat' "Romanss" jt)

  4. Sauga naised rajavad lugejale teed netikeskkonda / Silja Joon

    Index Scriptorium Estoniae

    Joon, Silja, 1966-

    2009-01-01

    Sauga raamatukogu juhataja Piia Salundi koos Šotimaal elava sõbratari Kerli Altmartiga asutasid e-raamatukogu. Abistas TTÜ teadur Andrei Errapart. Aadressil e-raamatukogu.com on üleval 72 raamatut 35 autorilt

  5. Water Security Toolkit User Manual Version 1.2.

    Energy Technology Data Exchange (ETDEWEB)

    Klise, Katherine A.; Siirola, John Daniel; Hart, David; Hart, William Eugene; Phillips, Cynthia Ann; Haxton, Terranna; Murray, Regan; Janke, Robert; Taxon, Thomas; Laird, Carl; Seth, Arpan; Hackebeil, Gabriel; McGee, Shawn; Mann, Angelica

    2014-08-01

    The Water Security Toolkit (WST) is a suite of open source software tools that can be used by water utilities to create response strategies to reduce the impact of contamination in a water distribution network . WST includes hydraulic and water quality modeling software , optimizati on methodologies , and visualization tools to identify: (1) sensor locations to detect contamination, (2) locations in the network in which the contamination was introduced, (3) hydrants to remove contaminated water from the distribution system, (4) locations in the network to inject decontamination agents to inactivate, remove, or destroy contaminants, (5) locations in the network to take grab sample s to help identify the source of contamination and (6) valves to close in order to isolate contaminate d areas of the network. This user manual describes the different components of WST , along w ith examples and case studies. License Notice The Water Security Toolkit (WST) v.1.2 Copyright c 2012 Sandia Corporation. Under the terms of Contract DE-AC04-94AL85000, there is a non-exclusive license for use of this work by or on behalf of the U.S. government. This software is distributed under the Revised BSD License (see below). In addition, WST leverages a variety of third-party software packages, which have separate licensing policies: Acro Revised BSD License argparse Python Software Foundation License Boost Boost Software License Coopr Revised BSD License Coverage BSD License Distribute Python Software Foundation License / Zope Public License EPANET Public Domain EPANET-ERD Revised BSD License EPANET-MSX GNU Lesser General Public License (LGPL) v.3 gcovr Revised BSD License GRASP AT&T Commercial License for noncommercial use; includes randomsample and sideconstraints executable files LZMA SDK Public Domain nose GNU Lesser General Public License (LGPL) v.2.1 ordereddict MIT License pip MIT License PLY BSD License PyEPANET Revised BSD License Pyro MIT License PyUtilib Revised BSD License Py

  6. Säravad ja kirglikud, naised mis naised / Liis Haab, Inga Allik ja Elisabet Tamm ; intervjueerinud Karli Randoja

    Index Scriptorium Estoniae

    Haab, Liis, 1987-

    2010-01-01

    Eestimaises seriaalis "Pilvede all" mängivad õdesid näitlejannad Liis Haab, Inga Allik ja Elisabet Tamm. Artiklis räägivad nad oma rollidest, koostööst võtteplatsil, endast ja oma riietumisstiilist

  7. Regioselectivity in the Thermal Rearrangement of Unsymmetrical 4-Methyl-4H-1,2,4-triazoles to 1-Methyl-1H-1,2,4-triazoles

    Directory of Open Access Journals (Sweden)

    Per H.J. Carlsen

    2001-11-01

    Full Text Available The rearrangement of 4-methyl-3,5-diaryl-4H-1,2,4-triazoles to the corresponding 1-methyl-3,5-diaryl-1H-1,2,4-triazoles showed regioselectivity comparable to that observed for the alkylation of 3,5-diaryl-1H-1,2,4-triazoles. This lends support to a proposed mechanism for the rearrangement that involves consecutive nucleophilic displacements steps.

  8. Deprotometalation-iodolysis and computed CH acidity of 1,2,3- and 1,2,4-triazoles. Application to the synthesis of resveratrol analogues.

    Science.gov (United States)

    Nagaradja, Elisabeth; Bentabed-Ababsa, Ghenia; Scalabrini, Mathieu; Chevallier, Floris; Philippot, Stéphanie; Fontanay, Stéphane; Duval, Raphaël E; Halauko, Yury S; Ivashkevich, Oleg A; Matulis, Vadim E; Roisnel, Thierry; Mongin, Florence

    2015-10-01

    1-Aryl- and 2-aryl-1,2,3-triazoles were synthesized by N-arylation of the corresponding azoles using aryl iodides. The deprotometalations of 1-phenyl-1,2,3-triazole and -1,2,4-triazole were performed using a 2,2,6,6-tetramethylpiperidino-based mixed lithium-zinc combination and occurred at the most acidic site, affording by iodolysis the 5-substituted derivatives. Dideprotonation was noted from 1-(2-thienyl)-1,2,4-triazole by increasing the amount of base. From 2-phenyl-1,2,3-triazoles, and in particular from 2-(4-trifluoromethoxy)phenyl-1,2,3-triazole, reactions at the 4 position of the triazolyl, but also ortho to the triazolyl on the phenyl group, were observed. The results were analyzed with the help of the CH acidities of the substrates, determined in THF solution using the DFT B3LYP method. 4-Iodo-2-phenyl-1,2,3-triazole and 4-iodo-2-(2-iodophenyl)-1,2,3-triazole were next involved in Suzuki coupling reactions to furnish the corresponding 4-arylated and 4,2'-diarylated derivatives. When evaluated for biological activities, the latter (which are resveratrol analogues) showed moderate antibacterial activity and promising antiproliferative effect against MDA-MB-231 cell line.

  9. Bioavailability of Clindamycin From a New Clindamycin Phosphate 1.2%-Benzoyl Peroxide 3% Combination Gel.

    Science.gov (United States)

    Jones, Terry M; Jasper, Stacy; Alió Sáenz, Alessandra B

    2013-01-01

    A new topical fixed-dose combination product containing clindamycin (1%, formulated as 1.2% clindamycin phosphate, CLNP 1.2%) with low strength (3%) benzoyl peroxide (BPO) in a methylparaben-free gel vehicle (CLNP 1.2%-BPO 3%-MPF) has been developed for the treatment of acne. The objective of this study was to determine the relative bioavailability of clindamycin and clindamycin sulfoxide from CLNP 1.2%-BPO 3%-MPF compared with clindamycin phosphate 1.2%-BPO 5% in a methylparaben-preserved gel vehicle (CLNP 1.2%-BPO 5%-MP) and clindamycin phosphate 1.2%-BPO 5% in a methylparaben-free gel vehicle (CLNP 1.2%-BPO 5%-MPF), and to determine whether exposure is affected by BPO concentration (3% vs. 5%) when applied topically. Seventy-two subjects with moderate-severe acne were randomized to receive CLNP 1.2%-BPO 3%-MPF, CLNP 1.2%-BPO 5%-MP, or CLNP 1.2%-BPO 5%-MPF in a 5-day, open-label, and parallel-group study. Cmax and AUC values for clindamycin were highest for CLNP 1.2%-BPO 5%-MP, followed by CLNP 1.2%-BPO 3%-MPF and CLNP 1.2%-BPO 5%-MPF, but differences were not statistically significant. Systemic exposure to clindamycin and clindamycin sulfoxide was low and comparable between the formulations. Results indicate that differences in BPO concentration do not influence clindamycin bioavailability.

  10. An Expeditious Synthesis of [1,2]Isoxazolidin-5-ones and [1,2]Oxazin-6-ones from Functional Allyl Bromide Derivatives

    Directory of Open Access Journals (Sweden)

    Imen Beltaïef

    2010-06-01

    Full Text Available Reaction of allyl bromide (Z-1 and (Z-2 with N-substituted hydroxylamine hydrochlorides in presence of tert-butoxide in tert-butanol at reflux provides a short and effective route to [1,2]isoxazolidin-5-ones 3 and [1,2]oxazin-6-ones 4.

  11. An Efficient Algorithm for Simulating the Real-Time Quantum Dynamics of a Single Spin-1/2 Coupled to Specific Spin-1/2 Baths

    NARCIS (Netherlands)

    Novotny, M.A.; Guerra, M.; Raedt, H. De; Michielsen, K.; Jin, F.

    2012-01-01

    An efficient algorithm for the computation of the real-time dependence of a single quantum spin-1/2 coupled to a specific set of quantum spin-1/2 baths is presented. The specific spin baths have couplings only with the spin operators Sx between bath spins and the central spin. We calculate spin expe

  12. Xenon preconditioning differently regulates p44/42 MAPK (ERK 1/2) and p46/54 MAPK (JNK 1/2 and 3) in vivo

    NARCIS (Netherlands)

    N.C. Weber; J. Stursberg; N.M. Wirthle; O. Toma; W. Schlack; B. Preckel

    2006-01-01

    Background. Xenon (Xe) induces preconditioning (PC) of the rat heart in vivo via activation of p38 mitogen-activated protein kinase (MAPK). The role of ERK 1/2 and JNK 1/2 and 3 in Xe-PC has yet not been determined. Methods. For infarct size measurements, anaesthetized rats were subjected to 25 min

  13. Synthesis and characterization of 5-heteroarylsulfanyl-4-aryl-1,2,3-selena/thiadiazoles

    Indian Academy of Sciences (India)

    Ramaiyan Manikannan; Masilamani Shanmugaraja; Seetharaman Manojveer; Shanmugam Muthusubramanian

    2012-03-01

    Synthesis and spectral characterization of 2-methyl-5-[(4-aryl-1,2,3-selenadiazol-5-yl)sulfanyl]-1,3,4-thiadiazoles, 5-[4-aryl-1,2,3-selenadiazol-5-yl]sulfanyl-1-phenyl-1-1,2,3,4-tetraazoles, 4-aryl-5-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-1,2,3-thiadiazole and 5-[4-aryl-1,2,3-thiadiazol-5-yl]sulfanyl-1-phenyl-1-1,2,3,4-tetraazole have been reported.

  14. Cross-talk between MEK1/2-ERK1/2 signaling and G protein-couple signaling in synoviocytes of collagen-induced arthritis rats

    Institute of Scientific and Technical Information of China (English)

    ZHANG Ling-ling; WEI Wei; WANG Qing-tong; CHEN Jing-yu; CHEN Yin

    2008-01-01

    Background Signaling pathways that regulate the production of cytokines and destructive enzymes have been implicated in rheumatoid arthritis (RA) pathogenesis.There are co-relations between signaling pathways.The aim of this study was to investigate interactions and cross-talks between MEK1/2-extracellular signal-related kinase (ERK1/2)signaling and G protein-couple signaling in synoviocytes of collagen-induced arthritis (CIA) rats by the stimulation of interleukin-1 (IL-1),U0126,isoprenaline hydrochloride and aminophyline respectively.Methods Twenty Sprague-Dawley (SD) rats were induced by chicken type Ⅱ collagen.Synoviocytes of CIA rats were isolated and cultured.The expressions of Gi,phosphorylated MEK1/2 (p-MEK1/2) and phosphorylated ERK1/2 (p-ERK1/2) were detected by Western blotting.cAMP level and protein kinase A (PKA) activity were measured by radioimmunoassay and kinase-glo(R) luminescent kinase assay respectively.Results There was remarkable inflammation in CIA rats accompanied by swelling paws,hyperplastic synovium,pannus and cartilage erosion,cAMP level and PKA activity of synoviocytes decreased.Gi,p-ERK1/2 and p-MEK1/2 increased,rIL-1α improved the expression of Gi,p-ERK1/2 and p-MEK1/2,cAMP and PKA increased with stimulation of rIL-1α.U0126 inhibited Gi,cAMP and PKA of synoviocytes stimulated by rIL-1α.Isoprenaline hydrochloride enhanced Gi,cAMP and PKA,but had no effects on p-MEK1/2 and p-ERK1/2.Aminophyline increased cAMP and PKA,but inhibited p-MEK1/2 and p-ERK1/2.Conclusions Mitogen-activated protein kinases (MAPKs) and G protein-couple signaling are associated with synovitis.There are cross talks between MAPKs and G protein-couple signaling.The two signaling pathways represent potential therapeutic targets for RA.

  15. Absence of HTLV-1/2 infection and dermatological diseases in Manaus, State of Amazonas, Brazil.

    Science.gov (United States)

    Passos, Leny Nascimento da Motta; Moraes, Márcia Poinho Encarnação de; Tamegão-Lopes, Bruna; Lemos, José Alexandre Rodrigues de; Machado, Paulo Roberto de Lima; Mira, Marcelo Távora; Talhari, Sinésio

    2014-07-01

    The prevalence of human T-cell lymphotropic virus types 1 and 2 (HTLV-1/2) infection is heterogeneous across different populations. We tested the hypothesis that HTLV-1/2 infection occurs more often in dermatological patients. A total of 1,091 patients from a tropical dermatology clinic were tested for HTLV-1/2. In parallel, 6865 first-time blood donors from the same geographic area were screened for HTLV-1/2; HTLV-1/2 positive blood donors underwent dermatological examinations. The prevalence of HTLV-1/2 in first-time blood donors was 0.14%. No co-occurrence of HTLV-1/2 infection and dermatological conditions was observed. Our results challenge the hypothesis that HTLV-1/2 infection occurs more often in dermatological patients.

  16. Measurement of hyperfine structure and isotope shift within the 7s1/2-7p1/2 transition in 203-Tl and 205-Tl

    CERN Document Server

    Ranjit, G; Vukasin, G D; Majumder, P K

    2013-01-01

    A two-step, two-color laser spectroscopy technique has been used to determine of the hyperfine splitting (HFS) of the 7p1/2 excited state in 203-Tl and 205-Tl, as well as the isotope shift within the 7s1/2 - 7p1/2 1301 nm transition. We find the hyperfine splittings in 203-Tl and 205-Tl to be 2152.2(7) MHz and 2173.3(8) MHz respectively. The 203-Tl - 205-Tl transition isotope shift is found to be 534.4(9) MHz. The HFS values each disagree by roughly 20 MHz from previously published values which quoted precision comparable to ours. In order to ensure accurate frequency-axis calibration in this new measurement, we employed both a Fabry-Perot cavity, as well as radio-frequency modulation to create sidebands in the absorption spectrum at well-defined frequency separation. In our experiment, one laser was locked to the ground-state 6p1/2 - 7s1/2 378 nm transition, while the second, spatially overlapping laser was scanned across the 7s1/2 (F=1) - 7p1/2 (F=0,1) hyperfine transitions.

  17. 1,2-环己二醇的焓和热容数据研究%Enthalpy and Heat Capacity Data for 1,2-Cyclohexanediol

    Institute of Scientific and Technical Information of China (English)

    周彩荣; 章亚东; 蒋登高

    2003-01-01

    The thermodynamic properties of different geometric structures of 1,2-cyclohexanediol which were rarely reported in literature, such as combustion enthalpy, formation enthalpy, melting enthalpy and heat capacities, were determined by NETZSCH DSC 204 Scanning Calorimeter. The relationship between the melting point and the composition for the mixture system of cis-1,2-cyclohexanediol and trans-1,2-cyclohexanediol was investigated and corresponding phase diagram was obtained. The melting enthMpies of both cis-1,2-cyclohexanediol and trans-1,2-cyclohexanediol are 20.265 kJ·mol-1 and 16.368 kJ·mol-1 respectively. The standard combustion enthalpies of cis- and trans-1,2-cyclohexaneddiol were determined by calorimeter. They are respectively -3507.043 kJ·mol-1 and -3497.8 k J·mol-1 at 298.15 K.The standard formation enthalpies are respectively 568.997kJ·mol-1and 578.240kJ·mol-1 for cis- and trans-1,2-cyclohexaneddiol.

  18. Phenotyping of Nod1/2 double deficient mice and characterization of Nod1/2 in systemic inflammation and associated renal disease

    Directory of Open Access Journals (Sweden)

    Ingrid Stroo

    2012-10-01

    It is indispensable to thoroughly characterize each animal model in order to distinguish between primary and secondary effects of genetic changes. The present study analyzed Nod1 and Nod2 double deficient (Nod1/2 DKO mice under physiological and inflammatory conditions. Nod1 and Nod2 are members of the Nucleotide-binding domain and Leucine-rich repeat containing Receptor (NLR family. Several inflammatory disorders, such as Crohn's disease and asthma, are linked to genetic changes in either Nod1 or Nod2. These associations suggest that Nod1 and Nod2 play important roles in regulating the immune system. Three-month-old wildtype (Wt and Nod1/2 DKO mice were sacrificed, body and organ weight were determined, and blood was drawn. Except for lower liver weight in Nod1/2 DKO mice, no differences were found in body/organ weight between both strains. Leukocyte count and composition was comparable. No significant changes in analyzed plasma biochemical markers were found. Additionally, intestinal and vascular permeability was determined. Nod1/2 DKO mice show increased susceptibility for intestinal permeability while vascular permeability was not affected. Next we induced septic shock and organ damage by administering LPS+PGN intraperitoneally to Wt and Nod1/2 DKO mice and sacrificed animals after 2 and 24 hours. The systemic inflammatory and metabolic response was comparable between both strains. However, renal response was different as indicated by partly preserved kidney function and tubular epithelial cell damage in Nod1/2 DKO at 24 hours. Remarkably, renal inflammatory mediators Tnfα, KC and Il-10 were significantly increased in Nod1/2 DKO compared with Wt mice at 2 hours. Systematic analysis of Nod1/2 DKO mice revealed a possible role of Nod1/2 in the development of renal disease during systemic inflammation.

  19. Pseudorabies Virus Triggers Glycoprotein gE-Mediated ERK1/2 Activation and ERK1/2-Dependent Migratory Behavior in T Cells

    Science.gov (United States)

    Setas Pontes, Maria; Devriendt, Bert

    2014-01-01

    ABSTRACT The interaction between viruses and immune cells of the host may lead to modulation of intracellular signaling pathways and to subsequent changes in cellular behavior that are of benefit for either virus or host. ERK1/2 (extracellular signal regulated kinase 1/2) signaling represents one of the key cellular signaling axes. Here, using wild-type and gE null virus, recombinant gE, and gE-transfected cells, we show that the gE glycoprotein of the porcine Varicellovirus pseudorabies virus (PRV) triggers ERK1/2 phosphorylation in Jurkat T cells and primary porcine T lymphocytes. PRV-induced ERK1/2 signaling resulted in homotypic T cell aggregation and increased motility of T lymphocytes. Our study reveals a new function of the gE glycoprotein of PRV and suggests that PRV, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior. IMPORTANCE Herpesviruses are known to be highly successful in evading the immune system of their hosts, subverting signaling pathways of the host to their own advantage. The ERK1/2 signaling pathway, being involved in many cellular processes, represents a particularly attractive target for viral manipulation. Glycoprotein E (gE) is an important virulence factor of alphaherpesviruses, involved in viral spread. In this study, we show that gE has the previously uncharacterized ability to trigger ERK1/2 phosphorylation in T lymphocytes. We also show that virus-induced ERK1/2 signaling leads to increased migratory behavior of T cells and that migratory T cells can spread the infection to susceptible cells. In conclusion, our results point to a novel function for gE and suggest that virus-induced ERK1/2 activation may trigger PRV-carrying T lymphocytes to migrate and infect other cells susceptible to PRV replication. PMID:25473050

  20. 10 CFR 960.3-1-2 - Diversity of rock types.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Diversity of rock types. 960.3-1-2 Section 960.3-1-2... NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-2 Diversity of rock types. Consideration... sites for characterization shall have different types of host rock....

  1. Anaerobic Biodegradation of Ethylene Dibromide and 1,2-Dichloroethane in the Presence of Fuel Hydrocarbons

    Science.gov (United States)

    Field evidence from underground storage tank sites where leaded gasoline leaked indicates the lead scavengers 1,2- dibromoethane (ethylene dibromide, or EDB) and 1,2- dichloroethane (1,2-DCA) may be present in groundwater at levels that pose unacceptable risk. These compounds are...

  2. 17 CFR 1.2 - Liability of principal for act of agent.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Liability of principal for act of agent. 1.2 Section 1.2 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Definitions § 1.2 Liability of principal for act of...

  3. A Quantum Monte Carlo Study on Mixed-Spin Chains of 1/2-1/2-1-1 and 3/2-3/2 -1-1

    Institute of Scientific and Technical Information of China (English)

    XU Zhao-Xin; ZHANG Jun; YING He-Ping

    2003-01-01

    The ground-state and thermodynamic properties of quantum mixed-spin chains of1/2-1/2-1-1and 3/2-3/2-1-1are investigated by a quantum Monte Carlo simulation with the loop-cluster algorithm. For 1/2-1/2-1-1 chain, we find it has two phases separated by an energy-gap vanishing point in the ground-state. For 3/2-3/2-1-1 chain, the numerical results show two energy-gap vanishing points isolated by different phases in its ground-state. Our calculations indicate that all these ground state phases can be understood by means of valence-bond-solid picture, and the thermodynamic behavior at finite temperatures is continuous as a function of parameterα=J2/J1.

  4. Electrical and microstructural properties of CaTiO3-doped K1/2Na1/2NbO3-lead free ceramics

    Indian Academy of Sciences (India)

    L Ramajo; R Parra; M A Ramírez; M S Castro

    2011-10-01

    Microstructure, electrical properties and dielectric behaviour of K1/2Na1/2NbO3 (KNN) and CaTiO3- modified K1/2Na1/2NbO3 (CTO-KNN) systems, were investigated. Discs doped with 0 to 0.55% mol of CaTiO3 (CTO) were sintered at 1125°C for 2 h. Although minority phases were found in doped samples, CaTiO3 was not detected. It was also observed that CTO changed the microstructure and grain size of KNN drastically. Also, the Curie temperature and permittivity values decreased. Addition of CTO between 0.15 and 0.45 mol% decreases the density and dielectric values. Samples prepared with higher content of CTO than 0.45 mol% showed better electrical properties.

  5. Synthesis of the new ring system bispyrido[4',3':4,5]pyrrolo [1,2-a:1',2'-d]pyrazine and its deaza analogue.

    Science.gov (United States)

    Parrino, Barbara; Spanò, Virginia; Carbone, Anna; Barraja, Paola; Diana, Patrizia; Cirrincione, Girolamo; Montalbano, Alessandra

    2014-08-29

    Derivatives of the new ring systems bispyrido[4',3':4,5]pyrrolo[1,2-a:1',2'-d] pyrazine-6,13-dione and its deaza analogue pyrido[4'',3'':4',5']pyrrolo-[1',2':4,5]pyrazino [1,2-a]indole-6,13-dione were conveniently synthesized through a four-step sequence. Symmetrical derivatives of the former ring system were obtained through self condensation. On the other hand, condensation of 6-azaindole carboxylic acid with indole 2-carboxylic acid afforded the deaza analogue ring system. Derivatives of the title ring system were tested by the National Cancer Institute (Bethesda, MD, USA) and four of them exhibited modest activity against MCF7 (a breast cancer cell line) and/or UO-31 (a renal cancer cell line).

  6. Synthesis of the New Ring System Bispyrido[4',3':4,5]pyrrolo [1,2-a:1',2'-d]pyrazine and Its Deaza Analogue

    Directory of Open Access Journals (Sweden)

    Barbara Parrino

    2014-08-01

    Full Text Available Derivatives of the new ring systems bispyrido[4',3':4,5]pyrrolo[1,2-a:1',2'-d] pyrazine-6,13-dione and its deaza analogue pyrido[4'',3'':4',5']pyrrolo-[1',2':4,5]pyrazino [1,2-a]indole-6,13-dione were conveniently synthesized through a four-step sequence. Symmetrical derivatives of the former ring system were obtained through self condensation. On the other hand, condensation of 6-azaindole carboxylic acid with indole 2-carboxylic acid afforded the deaza analogue ring system. Derivatives of the title ring system were tested by the National Cancer Institute (Bethesda, MD, USA and four of them exhibited modest activity against MCF7 (a breast cancer cell line and/or UO-31 (a renal cancer cell line.

  7. Magnetic and ferroelectric orders in strained Gd{sub 1/2}Na{sub 1/2}TiO{sub 3}: First-principles calculations

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, P. X. [Laboratory of Solid State Microstructures and Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093 (China); School of Science, Nantong University, Nantong 226007 (China); Dong, S., E-mail: sdong@seu.edu.cn [Department of Physics, Southeast University, Nanjing 211189 (China); Xie, Y. L.; Yan, Z. B.; Zhou, X. H.; Liu, J.-M., E-mail: liujm@nju.edu.cn [Laboratory of Solid State Microstructures and Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093 (China)

    2015-05-07

    The emergent magnetic and ferroelectric orders in A-site ordered Gd{sub 1/2}Na{sub 1/2}TiO{sub 3} under lattice strain are investigated using the first-principles calculations. It is revealed that the lattice prefers the perovskite structure with alternatively stacked Ga-O and Na-O layers along the b-axis and the ground spin state favors the G-type antiferromagnetic (G-AFM) order. The ac-plane biaxial strain can remarkably tune the amplitude of ferroelectric polarization, while the G-AFM spin structure is robustly unaffected. The ±4% strains can trigger the change of polarization up to ±50% relative to the polarization value of unstrained structure. The present work suggests a possible scenario to control emergent multiferroic behaviors in Gd{sub 1/2}Na{sub 1/2}TiO{sub 3} via lattice strain.

  8. Dielectric relaxation in lead-free perovskite Ba(Bi{sub 1/2}Nb{sub 1/2})O{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Prasad, K.; Bhagat, S.; Nath, K.A.; Choudhary, S.N. [Materials Research Laboratory, University Department of Physics, T. M. Bhagalpur University, Bhagalpur (India); Yadav, K.L. [Department of Physics, Indian Institute of Technology, Roorkee (India)

    2009-02-15

    A new lead-free perovskite ceramic Ba(Bi{sub 1/2}Nb{sub 1/2})O{sub 3} was prepared by a conventional ceramic technique at 1185 C in oxygen atmosphere. X-ray diffraction analysis of the compound indicated the formation of a single-phase monoclinic structure. Dielectric study revealed a diffuse phase transition at 340 C. Cole-cole analyses suggested the dielectric relaxation to be of non-Debye type. Electric modulus studies supported the hopping type of conduction in Ba(Bi{sub 1/2}Nb{sub 1/2})O{sub 3}. (copyright 2009 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  9. Beyond the Dimer and Trimer: Tetraspiro[2.1.2(5).1.2(9).1.2(13).1(3)] hexadecane-1,3,5,7-tetraone--the Cyclic Tetramer of Carbonylcyclopropane.

    Science.gov (United States)

    Sedenkova, Kseniya N; Averina, Elena B; Grishin, Yuri K; Andriasov, Kristian S; Stepanova, Svetlana A; Roznyatovsky, Vitaly A; Kutateladze, Andrei G; Rybakov, Victor B; Albov, Dmitry V; Kuznetsova, Tamara S; Zefirov, Nikolay S

    2016-03-14

    Tetraspiro[2.1.2(5).1.2(9).1.2(13).1(3)]hexadecane-1,3,5,7-tetraone 4, a unique tetraketone containing a cyclooctane core and four spiroannelated cyclopropane moieties, represents the previously unknown cyclotetramer of carbonylcyclopropane. For this purpose oxidation of the parent polyspirocyclic hydrocarbon was examined under various oxidative conditions, and the reactivity of oxidants towards methylene groups of the eight-membered cycle, activated by adjacent spirocyclopropane rings, was evaluated and contrasted. Whereas the treatment of tetraspirohexadecane with ozone resulted in monooxidation, its reaction with methyl(trifluoromethyl)dioxirane afforded the product of four-fold oxidation, triketoalcohol 10. Subsequent oxidation of the latter with Dess-Martin periodinane gave the target tetraketone 4.

  10. beta-acylvinyl anion and dianion equivalents: lithiation of 1-[(2EZ)-3-chloroprop-2-enyl]-1H-1,2,3-benzotriazole: preparation and elaboration of 1-(2-oxiranylvinyl)-1H-benzotriazoles.

    Science.gov (United States)

    Katritzky, Alan R; Manju, Kavita; Gromova, Anna V; Steel, Peter J

    2004-09-03

    The allyllithium generated from 1-[(2EZ)-3-chloroprop-2-enyl]-1H-1,2,3-benzotriazole (5) and LDA, in the presence of HMPA, reacts with enolizable and nonenolizable carbonyls solely at the CCl terminus to give 1-(2-oxiranylvinyl)benzotriazoles 6a-g in 61-82% yields. Allyllithiums generated from 6a,c reacted exclusively at the CBt terminus to give 10a-d in 68-88% yields. Acidic hydrolysis of (oxiranylvinyl)benzotriazoles 6a-g and 10a-d provided 4-hydroxyalk-2-en-1-one derivatives 12a,b,c,e,g, 13a-d, and furan 14 in 54-86% yields.

  11. Direct spectroscopy of the $^2$S$_{1/2}-^2$P$_{1/2}$ and $^2$D$_{3/2}-^2$P$_{1/2}$ transitions and observation of micromotion modulated spectra in trapped \\Ca

    CERN Document Server

    Pruttivarasin, Thaned; Haeffner, Hartmut

    2013-01-01

    We present an experimental scheme to perform spectroscopy of the $^2$S$_{1/2}-^2$P$_{1/2}$ and $^2$D$_{3/2}-^2$P$_{1/2}$ transitions in \\Ca. By rapidly switching lasers between both transitions, we circumvent the complications of both dark resonances and Doppler heating. We apply this method to directly observe the micromotion modulated fluorescence spectra of both transitions and measure the dependence of the micromotion modulation index on the trap frequency. With a measurement time of 10 minutes, we can detect the center frequencies of both dipole transitions with a precision on the order of 200 kHz even in the presence of strong micromotion.

  12. Tailoring the piezoelectric and relaxor properties of (Bi1/2 Na1/2) TiO3- BaTiO3 via zirconium doping

    DEFF Research Database (Denmark)

    Glaum, Julia; Simons, Hugh; Acosta, Matias

    2013-01-01

    This article details the influence of zirconium doping on the piezoelectric properties and relaxor characteristics of 94(Bi1/2Na1/2)TiO3-6Ba(ZrxTi1-x)O3 (BNT-6BZT) bulk ceramics. Neutron diffraction measurements of BNT-6BZT doped with 0%-15% Zr revealed an electric-field-induced transition...

  13. A facile synthesis of 1,2,3-triazolyl indole hybrids via SbCl3-catalysed Michael addition of indoles to 1,2,3-triazolyl chalcones

    Indian Academy of Sciences (India)

    Poovan Shanmugavelan; Murugan Sathishkumar; Sangaraiah Nagarajan; Alagusundaram Ponnuswamy

    2012-07-01

    An efficient, facile and environmentally benign synthesis of a library of 1,2,3-triazolyl chalcone hybrids (3a-u) has been accomplished by grinding the reactants at room temperature in excellent yields in very short reaction time. Subsequently, SbCl3 catalysed Michael addition of indoles to the chalcones afford 1,2,3-triazolyl indole hybrids (5a-l) in excellent yields.

  14. 1,2,3-Triazole N(2)-coordinated C-O coupling: Access to ortho aryloxyl 1,4-diaryl 1,2,3-triazoles

    Indian Academy of Sciences (India)

    YAOWEN LIU; FEN ZHAO; HAOHUA ZHOU; KAI XIE; YUBO JIANG

    2017-03-01

    CuI-catalyzed selective Ullmann C–O coupling of 1,4-disubstituted 1,2,3-triazole bromides with phenols were achieved through the coordination of N(2) atom. The ortho C–Br bond in N(1) aryl can be selectively coupled with phenols, while other C–Br bonds remain inert, generating ortho aryloxyl 1,4-diaryl1,2,3-triazoles.

  15. Zirconium Oxide Nanoparticles as an Efficient Catalyst for Three-Component Synthesis of Pyrazolo[1,2-A][1,2,4]Triazole-1,3-Diones Derivatives

    Directory of Open Access Journals (Sweden)

    Hossein Anaraki-Ardakani

    2016-06-01

    Full Text Available An efficient and green protocol for the synthesis of pyrazolo[1,2-a][1,2,4]triazole-1,3-diones derivatives by one pot, three component coupling reaction of aromatic aldehyde, malononitrile, and 4-phenylurazole has been developed using ZrO2 nanoparticles (NPs as the catalyst. The procedure is formed in high yields, short reaction time and an environmentally friendly specificity

  16. 1-(2-Chlorobenzyloxy-3-[1,2,3]triazol-1-yl-propan-2-ol Derivatives: Synthesis, Characterization, and DFT-Based Descriptors Analysis

    Directory of Open Access Journals (Sweden)

    Eloisa Román-Maldonado

    2017-01-01

    Full Text Available A novel series of 1-(2-chlorobenzyloxy-3-[1,2,3]triazol-1-yl-propan-2-ol derivatives was designed and synthesized using copper catalyzed alkyne-azide cycloaddition in the key step. Theoretical investigation of molecular and electronic properties by means of global and local reactivity indexes of the synthetized compounds was carried out, using DFT (Density Functional Theory at PBEPBE/6-31++G⁎⁎ level.

  17. The intracellular transport and secretion of calumenin-1/2 in living cells.

    Directory of Open Access Journals (Sweden)

    Qiao Wang

    Full Text Available Calumenin isoforms 1 and 2 (calu-1/2, encoded by the CALU gene, belong to the CREC protein family. Calu-1/2 proteins are secreted into the extracellular space, but the secretory process and regulatory mechanism are largely unknown. Here, using a time-lapse imaging system, we visualized the intracellular transport and secretory process of calu-1/2-EGFP after their translocation into the ER lumen. Interestingly, we observed that an abundance of calu-1/2-EGFP accumulated in cellular processes before being released into the extracellular space, while only part of calu-1/2-EGFP proteins were secreted directly after attaching to the cell periphery. Moreover, we found the secretion of calu-1/2-EGFP required microtubule integrity, and that calu-1/2-EGFP-containing vesicles were transported by the motor proteins Kif5b and cytoplasmic dynein. Finally, we determined the export signal of calu-1/2-EGFP (amino acid positions 20-46 and provided evidence that the asparagine at site 131 was indispensable for calu-1/2-EGFP stabilization. Taken together, we provide a detailed picture of the intracellular transport of calu-1/2-EGFP, which facilitates our understanding of the secretory mechanism of calu-1/2.

  18. Immunohistochemical and western blot analysis suggest that the soluble forms of FGF1-2 and FGFR1-2 sustain tail regeneration in the lizard.

    Science.gov (United States)

    Alibardi, Lorenzo

    2017-08-18

    Fibroblast Growth Factors 1-2 (FGF1-2) stimulate tail regeneration in lizards and therefore the distribution of their receptors, FGFR1-2, in the regenerating tail of the lizard. Podarcis muralis has been studied using immunofluorescence and western blotting. Immunoreactive protein bands at 15-16kDa for FGF1-2 in addition to those at 50-65kDa are detected in the regenerating epidermis, but weak bands at 35, 45 and 50kDa appear from the regenerating connective tissues. Strongly immunolabeled bands for FGFR1 at 32, 60, and 80kDa and less intense for FGFR2 only appear in the regenerating tail. In normal tail epidermis and dermis, higher MW forms are present at 80 and 115-140kDa, respectively, but they disappear in the regenerating epidermis and dermis where low MW forms of FGFR1-2 are found at 50-70kDa. Immunolocalization confirms that most FGFR1-2 are present in the wound epidermis, Apical Epidermal Peg, ependymal tube while immunolabeling lowers in regenerating muscles, blastema cells, cartilage and connectives tissues. The likely release of FGFs from the Apical Epidermal Peg and ependyma and the presence of their receptors in these tissues may determine the autocrine stimulation of proliferation and a paracrine stimulation of the blastema cells through their FGF Receptors. Copyright © 2017 Elsevier GmbH. All rights reserved.

  19. Effect of substitution of titanium by magnesium and niobium on structure and piezoelectric properties in (Bi1/2Na1/2)TiO3 ceramics

    Indian Academy of Sciences (India)

    Zhou Chang-Rong; Liu Xin-Yu; Li Wei-Zhou; Yuan Chang-Lai

    2011-12-01

    To develop new (Bi1/2Na1/2)TiO3-based ceramics with excellent piezoelectric properties, the similarities and the differences between PZT and (Bi1/2Na1/2)TiO3 ceramics were analysed. Based on the analysis, a new (Bi1/2Na1/2)TiO3-based piezoelectric ceramic of B-site substitution of complex ions (Mg1/3Nb2/3)4+ for Ti4+ was prepared by a conventional ceramic technique, and the effect of complex ions (Mg1/3Nb2/3)4+ addition on the microstructure, dielectric and piezoelectric properties was investigated. The research results show that all compositions are mono-perovskite phase and the grain size increases with increasing content of (Mg1/3Nb2/3)4+. The piezoelectric constant $d_{33}$ first increases and then decreases, and electromechanical coupling factor $k_{p}$ varies insignificantly with increasing content of (Mg1/3Nb2/3)4+.

  20. Effect of substitution of titanium by magnesium and niobium on structure and piezoelectric properties in (Bi1/2Na1/2)TiO3 ceramics

    Indian Academy of Sciences (India)

    Zhou Chang-Rong; Liu Xin-Yu; Li Wei-Zhou; Yuan Chang-Lai

    2009-02-01

    To develop new (Bi1/2Na1/2)TiO3-based ceramics with excellent piezoelectric properties, the similarities and the differences between PZT and (Bi1/2Na1/2)TiO3 ceramics were analysed. Based on the analysis, a new (Bi1/2Na1/2)TiO3-based piezoelectric ceramic of B-site substitution of complex ions (Mg1/3Nb2/3)4+ for Ti4+ was prepared by a conventional ceramic technique, and effect of complex ions (Mg1/3Nb2/3)4+ addition on the microstructure, dielectric and piezoelectric properties was investigated. The results show that all compositions are mono-perovskite phase and the grain size increases with increasing content of (Mg1/3Nb2/3)4+. The piezoelectric constant, 33, first increases and then decreases, and electromechanical coupling factor, p, varies insignificantly with increasing content of (Mg1/3Nb2/3)4+.

  1. 正整数n-color 1-2有序分拆%n-color 1-2 compositions of positive integers

    Institute of Scientific and Technical Information of China (English)

    郭育红

    2015-01-01

    正整数的n-color 1-2有序分拆是指正整数的只含有分部量是1或者2的n-color有序分拆,而正整数的回文的n-color 1-2有序分拆是指只含有分部量是1或者2的n-color有序分拆且分部量从前往后读与从后往前读是相等的.这里给出了正整数的n-color 1-2有序分拆数和回文的n-color 1-2有序分拆数的生成函数、显式公式以及递推公式.而且还给出了正整数的n-color 1-2有序分拆数和回文的n-color 1-2有序分拆数之间的一个关系式.

  2. Neural network wind retrieval from ERS -1/2 scatterometer data

    Institute of Scientific and Technical Information of China (English)

    LIN Mingsen; SONG Xingai; JIANG Xingwei

    2006-01-01

    A neural network methodology is presented to retrieve wind vectors from ERS - 1/2 scatterometer data. The wind directional ambiguities are eliminated by a circular median filter algorithm. All data come from ERS - 1/2 scatterometer data collocated pairs with CMCD4 vector. Comparing the results with CMCD4 and ECMWF wind vector,they agree well, which indicates that it is possible to extract wind vector from the ERS-1/2 scatterometer with the neural network method.

  3. Young tableaux and crystal base for U_q(osp(1|2n))

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Let Uq(osp(1|2n)) be the quantized enveloping superalgebra corresponding to the Lie superalgebra osp(1|2n). In terms of semistandard Young tableaux satisfying some additional conditions, a realization of crystal graph of finite-dimensional irreducible modules of Uq(osp(1|2n)) is given. Also, the generalized LittlewoodRichardson rule for tensor product of crystal graphs is established.

  4. 6p1/2,3/2nf J = 1-5 autoionizing series of Barium

    NARCIS (Netherlands)

    Abutaleb, M.; Graaff, de R.J.; Ubachs, W.M.G.; Hogervorst, W.

    1991-01-01

    The 6pnf series of barium converging to both 6p1/2 and 6p3/2 limits were investigated in a two-step pulsed-laser experiment. From 6s5d 3D1,2,3 metastable atoms, discharge populated in an atomic beam, 11 out of the full manifold of 12 autoionizing 6p1/2,3/2nf J = 1-5 Rydberg series were excited via

  5. Solution phase isomerization of vibrationally excited singlet nitrenes to vibrationally excited 1,2-didehydroazepine.

    Science.gov (United States)

    Burdzinski, Gotard T; Middleton, Chris T; Gustafson, Terry L; Platz, Matthew S

    2006-11-22

    Photolysis of phenyl and o-biphenylyl azide (at 270 nm) releases vibrationally excited singlet nitrene which isomerizes to the corresponding hot 1,2-didehydroazepine at a rate competitive with thermal relaxation. Using ultrafast vibrational spectroscopy we observe the formation of vibrationally excited 1,2-4,6-azacycloheptatetraene (1,2-didehydroazepine) in picoseconds following photolysis of phenyl azide in chloroform and o-biphenylyl azide in acetonitrile at ambient temperature.

  6. Cellular mechanisms and behavioral consequences of Kv1.2 regulation in the rat cerebellum

    Science.gov (United States)

    Williams, Michael R; Fuchs, Jason R; Green, John T; Morielli, Anthony D

    2012-01-01

    The potassium channel Kv1.2 alpha-subunit is expressed in cerebellar Purkinje cell (PC) dendrites where its pharmacological inhibition increases excitability (Khavandgar et al., 2005). Kv1.2 is also expressed in cerebellar basket cell (BC) axon terminals (Sheng et al., 1994), where its blockade increases BC inhibition of PCs (Southan and Robertson, 1998a). Secretin receptors are also expressed both in PC dendrites and BC axon terminals (reviewed in (Yuan et al.). The effect of secretin on PC excitability is not yet known, but, like Kv1.2 inhibitors, secretin potently increases inhibitory input to PCs (Yung et al., 2001). This suggests secretin may act in part by suppressing Kv1.2. Receptor-mediated endocytosis is a mechanism of Kv1.2 suppression (Nesti et al., 2004). This process can be regulated by protein kinase A (PKA) (Connors et al., 2008). Since secretin receptors activate PKA (Wessels-Reiker et al., 1993), we tested the hypothesis that secretin regulates Kv1.2 trafficking in the cerebellum. Using cell surface protein biotinylation of rat cerebellar slices, we found secretin decreased cell-surface Kv1.2 levels by modulating Kv1.2 endocytic trafficking. This effect was mimicked by activating adenylate cyclase (AC) with forskolin, and was blocked by pharmacological inhibitors of AC or PKA. Imaging studies identified the BC axon terminal and Purkinje cell dendrites as loci of AC-dependent Kv1.2 trafficking. The physiological significance of secretin regulated Kv1.2 endocytosis is supported by our finding that infusion into the cerebellar cortex of either the Kv1.2 inhibitor Tityustoxin-Kα, or of the Kv1.2 regulator secretin, significantly enhances acquisition of eyeblink conditioning in rats. PMID:22764231

  7. Identification and Characterization of 1,2-BN Cyclohexene Using Microwave Spectroscopy

    Science.gov (United States)

    Kukolich, Stephen G.; Sun, Ming; Daly, Adam M.; Ishibashi, Jacob S. A.; Liu, Shih-Yuan

    2016-06-01

    1,2-BN Cyclohexene was produced from 1,2-BN Cyclohexane through the loss of H_2 and characterized and identified using a pulsed-beam Fourier-transform microwave spectrometer. The first microwave spectra for 1,2-10BN Cyclohexene 1,2-11BN Cyclohexene have been measured in the frequency range of 5.5-12.5 GHz, providing accurate rotational constants and nitrogen and boron quadrupole coupling strengths for two isotopologues. High-level ab initio calculations provided rotational constants and quadrupole coupling strengths for the precursor 1,2-BN Cyclohexane (C_4H12BN) and 1,2-BN Cyclohexene(C_4H10BN). Calculated molecular properties for 1,2-BN Cyclohexene are in very good agreement with measured parameters. Calculated parameters for the starting material, 1,2-BN Cyclohexane do not agree with the experimental data. Rotational constants for 1,2-11BN Cyclohexene are A = 4702.058(2) MHz, B = 4360.334(1) MHz and C = 2494.407(1) MHz. The inertial defect is Δ_0 = -20.78 amu-Å^2 clearly indicating a nonplanar structure. These microwave experiments show that heating the initial compound, 1,2-BN Cyclohexane, to 60 C in a 1 atm neon stream results in the loss of H_2 and conversion to 1,2-BN Cyclohexene. This appears to be the first characterization of the 1,2-BN Cyclohexene monomer. Supported by the NSF CHE-1057796 and DOE DE-EE-0005658

  8. Research on the Lyophilization Technology of 1,2-Methylene Dichloride%1,2-二氯乙烷冷冻干燥工艺的研究

    Institute of Scientific and Technical Information of China (English)

    张金娜; 祁锦成; 朱春来

    2012-01-01

    1,2-二氯乙烷是一种常用的有机溶剂,在很多工业生产中作为溶剂时可重复使用,但在一些要求无水条件下进行反应的生产中,需对其回收后进行干燥,达到要求后方可使用.文章对二氯乙烷回收采用的冷冻干燥工艺进行研究.%1,2- methylene dichloride is a kind of common organic solvent and can be recycled in industrial production. But some reactions need it without any water. So it can be used only after it is reclaimed and dried. To recycle it, the lyophilization technology of 1,2 - methylene dichloride is researched in the article.

  9. The [17.0] 2Π1/2← X 2Π1/2 system of AlCa

    Science.gov (United States)

    Fabbi, Jacqueline C.; Langenberg, Jon D.; Morse, Michael D.

    2000-04-01

    Laser-induced fluorescence spectroscopy has been used to study supersonically cooled AlCa. This study investigates under higher resolution (0.007 cm-1) a single band previously studied and tentatively assigned as the (0-0) vibrational transition of the [17.0] 2Δ3/2(?)← X 2Π1/2 system of AlCa. The resolution of the rotational structure in the present study enabled a definite assignment as a 2Π1/2← 2Π1/2 transition. Analysis of the spectrum gives B0'=0.096685(19) cm-1, ( p+2 q)'=-0.013078(370) cm -1, and B0″=0.105518(20) cm -1. These convert to ground and excited state bond lengths of r0″=3.14942(30) and r0'=3.29014(32) Å, respectively.

  10. Electrochemical Reduction of 1,2-Di(p-tolylimino)ethane and 1,2-Di(2,4-dimethylphenylimino)ethane in Dimethylformamide

    Institute of Scientific and Technical Information of China (English)

    FOTOUHI, Lida; ZEIENALI, Mahbobeh; DEHGHANPOUR, Saeed; NEMATOLLAHI, Davood

    2007-01-01

    1,2-Di(p-tolylimino)ethane (Ⅰ) and 1,2-Di(2,4-dimethylphenylimino)ethane (Ⅱ) were synthesized and their electrochemical behavior investigated in dimethylformamide using classical voltammetry, differential pulse voltammetry, cyclic voltammetry, chronoamperometry, controlled potential electrolysis and coulometry. Both bis-Schiff base ligands examined show a cathodic irreversible peak which corresponds to one-electron reduction of the substrate to form anion radical. According to the fact obtained from cyclic voltammetry, that the current function(ip/v1/2) is a decreasing function of the scan rate, it can be concluded that there is a following coupling chemical reaction (EC mechanism). Thus, the most probable mechanism of electroreduction of both ligands is the coupling of two radicals to form a dimer.

  11. Probing mechanisms of axonopathy. Part I: Protein targets of 1,2-diacetylbenzene, the neurotoxic metabolite of aromatic solvent 1,2-diethylbenzene.

    Science.gov (United States)

    Tshala-Katumbay, Desire; Monterroso, Victor; Kayton, Robert; Lasarev, Michael; Sabri, Mohammad; Spencer, Peter

    2008-09-01

    Motor neuron axonopathy in diseases such as amyotrophic lateral sclerosis can be modeled and probed with neurotoxic chemicals that induce similar patterns of pathology, such as axonal spheroids that represent focal accumulation of anterogradely transported neurofilaments (NFs). The aromatic gamma-diketone-like 1,2-diacetylbenzene (1,2-DAB), but not its 1,3-DAB isomer, reacts with epsilon-amino- or sulfyhydryl groups of (neuro)proteins, forms adducts, and causes NFs to accumulate at proximal sites of elongate motor axons. We exploit the protein-reactive properties of neurotoxic 1,2-DAB versus the nonprotein-reactive properties of non-neurotoxic 1,3-DAB to unveil proteomic changes associated with this type of pathology. We used two-dimensional differential in-gel electrophoresis (2D-DIGE), matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry to analyze the lumbosacral spinal cord proteome of adult Sprague-Dawley rats treated systemically with 20 mg/kg/day 1,2-DAB, equimolar dose of 1,3-DAB, or equivalent volume of vehicle (saline containing 2% acetone), 5 days a week, for 2 weeks. 1,2-DAB significantly altered the expression of protein disulfide isomerase, an enzyme involved in protein folding, and gelsolin, an actin-capping and -severing protein. Modifications of these two proteins have been incriminated in the pathogenesis of nerve fiber degeneration. Protein-reactive and neurotoxic 1,2-DAB appears to be excellent tool to dissect mechanisms of nerve fiber (axon) degeneration.

  12. TREATMENT AND RESOURCE REUSE OF 1,2,4-ACID PRODUCING EFFLUENT WITH MACROPOROUS POLYMERIC ADSORBENT

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The treatment and resource reuse of 1,2,4-acid producing wastewater by self-mademacroporous adsorption resin ND,A-107 was studied in this paper. Optimum adsorption anddesorption process parameters were acquired by systematically study. The polymeric resin NDA-10 7indicated good adsorption & desorption of 1,2, 4-acid in the wastewater. The removal efficiency of1,2,4-acid, CODer is about 78%, 72% respectively. It is evident that this adsorption process is anefficient treatment method for 1,2,4-acid producing wastewater. At the same time, the accumulationand resource reuse of l,2, 4-acid can be realized in this process.

  13. Synthesis and Thermal Behavior of a Fused, Tricyclic 1,2,3,4-Tetrazine Ring System.

    Science.gov (United States)

    Chavez, David E; Bottaro, Jeffery C; Petrie, Mark; Parrish, Damon A

    2015-10-26

    This study presents the synthesis and characterization of a fused, tricyclic 1,2,3,4-tetrazine ring system. The molecule is synthesized in a three-step process from 5,5'-dinitro-bis,1,2,4-triazole via a di-N-amino compound. Oxidation to form the azo-coupled fused tricyclic 1,2,3,4-tetrazine is achieved using tert-butyl hypochlorite as the oxidant. The di-N-amino compound and the desired fused tricyclic 1,2,3,4-triazine display interesting thermal behavior and are predicted to be high-performance energetic materials.

  14. Synthesis of new tetrazene(N-N=N-N)-linked bi(1,2,4-triazole)

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The reaction of 4-amino-1,2,4-triazole with sodium dichloroisocyanurate (SDCI) afforded new tetrazene(N-N=N-N)-linked bi(1,2,4-triazole) 2a in excellent yield. Increasing the molar ratio of SDCI to 4-amino- 1,2,4-triazole, the chlorinated product 1,5,5'-trichloro-4,4'-azo- 1,2,4-triazole (2b) was formed. These new compounds have been characterized by MS, 1H NMR, 13C NMR, and elemental analysis.

  15. Oral contraceptives and breast cancer risk in the international BRCA1/2 carrier cohort study

    DEFF Research Database (Denmark)

    Brohet, Richard M; Goldgar, David E; Easton, Douglas F

    2007-01-01

    oral contraceptive use and risk of breast cancer among BRCA1/2 carriers. PATIENTS AND METHODS In the International BRCA1/2 Carrier Cohort study (IBCCS), a retrospective cohort of 1,593 BRCA1/2 mutation carriers was analyzed with a weighted Cox regression analysis. Results We found an increased risk...... was found among BRCA1/2 mutation carriers that current use of oral contraceptives is associated with risk of breast cancer more strongly than is past use, as is found in the general population. However, duration of use, especially before first full-term pregnancy, may be associated with an increasing risk...

  16. Integrable quantum field theories with supergroup symmetries the $OSP(1\\/2)$ case

    CERN Document Server

    Saleur, H; Saleur, Hubert; Wehefritz-Kaufmann, Birgit

    2003-01-01

    As a step to understand general patterns of integrability in 1+1 quantum field theories with supergroup symmetry, we study in details the case of $OSP(1/2)$. Our results include the solutions of natural generalizations of models with ordinary group symmetry: the $UOSP(1/2)_{k}$ WZW model with a current current perturbation, the $UOSP(1/2)$ principal chiral model, and the $UOSP(1/2)\\otimes UOSP(1/2)/UOSP(1/2)$ coset models perturbed by the adjoint. Graded parafermions are also discussed. A pattern peculiar to supergroups is the emergence of another class of models, whose simplest representative is the $OSP(1/2)/OSP(0/2)$ sigma model, where the (non unitary) orthosymplectic symmetry is realized non linearly (and can be spontaneously broken). For most models, we provide an integrable lattice realization. We show in particular that integrable $osp(1/2)$ spin chains with integer spin flow to $UOSP(1/2)$ WZW models in the continuum limit, hence providing what is to our knowledge the first physical realization of a ...

  17. Thermal Rearrangement of Allyl Substituted Unsymmetric 4H-1,2,4-Triazoles to the Corresponding 1H-1,2,4-triazoles

    Directory of Open Access Journals (Sweden)

    Per H.J. Carlsen

    2001-04-01

    Full Text Available A series of neat 4-(2-alkenyl substituted 5-methyl-3-phenyl-4H-1,2,4-triazoles were thermolyzed at 320 oC producing a rearrangement products, of which the regioisomeric 1- and 2-substituted triazoles were the main products. The group migrations were rationalized in terms of consecutive SN2-type reactions. This mechanism was supported by a study of the alkylations of the triazoles which gave similar product mixtures. 4-(2-alkenyl substituted 3-phenyl-4H-1,2,4-triazoles, on the other hand, gave predominantly elimination products.

  18. High resolution photoassociation spectra of an ultracold Cs2 long-range 0u+ (6S1/2 + 6P1/2) state

    Science.gov (United States)

    Chen, Peng; Li, Yu-Qing; Zhang, Yi-Chi; Wu, Ji-Zhou; Ma, Jie; Xiao, Lian-Tuan; Jia, Suo-Tang

    2013-09-01

    In this paper, ultracold cesium molecules are formed through photoassociation technology, which is carried out in a magneto-optical trap. High resolution photoassociaion spectra with the rotational progressions up to J = 7 are obtained. Three rovibrational levels of the long-range 0u+ state of Cs2 below the (6S1/2 + 6P1/2) dissociation limit are specifically investigated. By fitting their binding energy intervals to the non-rigid rotational model, the rotational constant of the long-range 0u+ state is determined. A proportional dependence of the value of the rotational constant on the vibrational quantum number is demonstrated.

  19. INFLUENCE OF 1-BUTANOL, 1,2-BUTANEDIOL AND1,2,3,4-BUTANETETROL ON THE ADSORPTION OF β-LACTOGLOBULINAT THE AIR-WATER INTERFACE

    Directory of Open Access Journals (Sweden)

    Carmen María Romero

    2011-11-01

    Full Text Available In this work, a systematic study on theeffect of 1-butanol, 1,2-butanediol and1,2,3,4-butanetetrol (erythritol on thesurface tension of β-lactoglobulin inaqueous solution at pH 6.5 and 298.15K is presented.The experimental data were used tocalculate the surface pressure and wereadjusted to different protein adsorptionmodels at the liquid-air interface to explainthe behavior of β-lactoglobulin inaqueous solution. The results show thatthe alcohols produce a significant effecton the adsorption behavior of the proteinat the interface that is related to the numberof hydroxyl groups.

  20. Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2.

    Science.gov (United States)

    Yamagata, Tetsushi; Ogiwara, Ikuo; Mazaki, Emi; Yanagawa, Yuchio; Yamakawa, Kazuhiro

    2017-09-30

    Nav1.1 and Nav1.2 are the voltage-gated sodium channel pore-forming alpha I and II subunits, encoded by the genes SCN1A and SCN2A. Although mutations of both genes have similarly been described in patients with epilepsy, autism and/or intellectual disability, their expression sites in brain are largely distinct. Nav1.1 was shown to be expressed dominantly in parvalbumin (PV)-positive or somatostatin (SST)-positive inhibitory neurons and in a sparsely-distributed subpopulation of excitatory neurons. In contrast, Nav1.2 has been reported to be dominantly expressed in excitatory neurons. Here we show that Nav1.2 is also expressed in caudal ganglionic eminence (CGE)-derived inhibitory neurons, and expressions of Nav1.1 and Nav1.2 are mutually-exclusive in many of brain regions including neocortex, hippocampus, cerebellum, striatum and globus pallidus. In neocortex at postnatal day 15, in addition to the expression in excitatory neurons we show that Nav1.2 is expressed in reelin (RLN)-positive/SST-negative inhibitory neurons that are presumably single-bouquet cells because of their cortical layer I-limited distribution, and vasoactive intestinal peptide (VIP)-positive neurons that would be multipolar cell because of their layer I/II margin and layer VI distribution. Although Nav1.2 has previously been reported to be expressed in SST-positive cells, we here show that Nav1.2 is not expressed in either of PV-positive or SST-positive inhibitory neurons. PV-positive and SST-positive inhibitory neurons derive from medial ganglionic eminence (MGE) and innervate excitatory neurons, while VIP-positive and RLN-positive/SST-negative inhibitory neurons derive from CGE, innervate on inhibitory neurons and play disinhibitory roles in the neural network. Our results therefore indicate that, while Nav1.1 is expressed in MEG-derived inhibitory neurons, Nav1.2 is expressed in CGE-derived disinhibitory interneurons in addition to excitatory neurons. These findings should contribute to

  1. Practical and Efficient Synthesis of α-Aminophosphonic Acids Containing 1,2,3,4-Tetrahydroquinoline or 1,2,3,4-Tetrahydroisoquinoline Heterocycles.

    Science.gov (United States)

    Ordóñez, Mario; Arizpe, Alicia; Sayago, Fracisco J; Jiménez, Ana I; Cativiela, Carlos

    2016-08-31

    We report here a practical and efficient synthesis of α-aminophosphonic acid incorporated into 1,2,3,4-tetrahydroquinoline and 1,2,3,4-tetrahydroisoquinoline heterocycles, which could be considered to be conformationally constrained analogues of pipecolic acid. The principal contribution of this synthesis is the introduction of the phosphonate group in the N-acyliminium ion intermediates, obtained from activation of the quinoline and isoquinoline heterocycles or from the appropriate δ-lactam with benzyl chloroformate. Finally, the hydrolysis of phosphonate moiety with simultaneous cleavage of the carbamate afforded the target compounds.

  2. Synthesis, antiinflammatory and HIV-1 integrase inhibitory activities of 1,2-bis[5-thiazolyl]ethane-1,2-dione derivatives

    Directory of Open Access Journals (Sweden)

    Franklin P

    2009-01-01

    Full Text Available Based on principles of pharmacophore delineation and drug designing, compounds containing diketofunctionallity namely 1,2-bis[5-thiazolyl]ethane-1,2-diones were designed and synthesized as antiinflammatory agents. The compounds were evaluated in carrageenan-induced rat-paw edema method. G-3, G-6, G-17, G-20, G-23, G-22, L-708 and 906 showed good antiinflammatory activity. In addition as diketo functionality containing compounds are reported to have HIV-1 integrase inhibitory property, and these compounds contains diketo functionality, so these compounds were screened in assay for HIV-1 integrase inhibition. Few compounds showed weak HIV-1 integrase Inhibitory activity.

  3. Vanadium(III chloride complexes of 1,2-bis-(5-H/methyl/chloro/nitro-1H-benzimidazol-2-yl-1,2-ethanediols

    Directory of Open Access Journals (Sweden)

    AYDIN TAVMAN

    2006-05-01

    Full Text Available The complexes of 1,2-bis-(5-H/methyl/chloro/nitro-1H-benzimidazol-2-yl-1,2-ethanediols (L1-L4 with VCl3 were synthesized and characterized by elemental analyses, molar conductivity, FTIR and 1H-NMR spectroscopy. The ligands act as bidentate coordinating through both of the hydroxyl group oxygen atoms in the complexes. The ionic and diamagnetic complexes have the empirical formula [V(L2]Cl3. The [V(L42]Cl3 complex has two isomeric structures according to the 1H-NMR spectral data.

  4. (4R-4-(2-Allyl-2H-1,2,3-triazol-4-yl-1,2-O-isopropylidene-l-threose

    Directory of Open Access Journals (Sweden)

    David J. Watkin

    2008-12-01

    Full Text Available X-ray crystallography unequivocally confirmed the structure of the title compound, C12H17N3O4, as (4R-4-(2-allyl-2H-1,2,3-triazol-4-yl-1,2-O-isopropylidene-l-threose. The absolute configuration was determined by the use of d-glucorono-3,6-lactone as the starting material. The crystal structure consists of hydrogen-bonded chains of molecules running parallel to the a axis. There are no unusual packing features.

  5. Two-point spin-1/2-spin-1/2 sl(2,bfC) conformal Kac-Moody blocks on the torus and their monodromies

    Energy Technology Data Exchange (ETDEWEB)

    Smyrnakis, J.M. [Columbia Univ., New York, NY (United States). Dept. of Mathematics

    1995-10-02

    Two issues of the SU(2) Wess-Zumino-Witten model are examined here, namely the computation of the untwisted conformal Kac-Moody blocks on the torus and their monodromy representations. Using the free field representation developed by Bernard and Felder, an integral representation of the twisted two point spin-1/2-spin-1/2 conformal Kac-Moody blocks on the torus is computed. From this, an integral representation of the untwisted blocks is computed after careful removal of infinities. Finally, the untwisted blocks are used to get a representation of the Braid Group on the torus on two strings, in terms of quantum group q-numbers. (orig.).

  6. [1,2-Bis(dicyclohexylphosphanyl-1,2-dicarba-closo-dodecaborane-2κ2P,P′]di-μ-chlorido-1:2κ4Cl:Cl-dichlorido-1κ2Cl-dimercury(II

    Directory of Open Access Journals (Sweden)

    Liguo Yang

    2014-04-01

    Full Text Available The title compound, [Hg2Cl4(C26H54B10P2], was synthesized by the reaction of 1,2-bis(dicyclohexylphosphanyl-1,2-dicarba-closo-dodecaborane with HgCl2. Both HgII atoms show a distorted tetrahedral coordination geometry, provided by the two bridging chloride anions and the P atoms of the diphosphanyl ligand for one metal atom, and by two bridging and two terminal chloride anions for the other. The five-membered HgP2C2 chelate ring assumes an envelope conformation, with the HgII atom displaced by 0.1650 (5 Å from the mean plane of the other four atoms (r.m.s. deviation = 0.002 Å. In the crystal, B—H...Cl interactions link the molecules, forming a supramolecular chain along the a-axis direction.

  7. Dehalogenimonas lykanthroporepellens BL-DC-9T simultaneously transcribes many rdhA genes during organohalide respiration with 1,2-DCA, 1,2-DCP, and 1,2,3-TCP as electron acceptors.

    Science.gov (United States)

    Mukherjee, Kalpataru; Bowman, Kimberly S; Rainey, Fred A; Siddaramappa, Shivakumara; Challacombe, Jean F; Moe, William M

    2014-05-01

    The genome sequence of the organohalide-respiring bacterium Dehalogenimonas lykanthroporepellensBL-DC-9(T) contains numerous loci annotated as reductive dehalogenase homologous (rdh) genes based on inferred protein sequence identity with functional dehalogenases of other bacterial species. Many of these genes are truncated, lack adjacent regulatory elements, or lack cognate genes coding for membrane-anchoring proteins typical of the functionally characterized active reductive dehalogenases of organohalide-respiring bacteria. To investigate the expression patterns of the rdh genes in D. lykanthroporepellensBL-DC-9(T), oligonucleotide primers were designed to uniquely target 25 rdh genes present in the genome as well as four putative regulatory genes. RNA extracts from cultures of strain BL-DC-9(T) actively dechlorinating three different electron acceptors, 1,2-dichloroethane, 1,2-dichloropropane, and 1,2,3-trichloropropane were reverse-transcribed and subjected to PCR amplification using rdh-specific primers. Nineteen rdh gene transcripts, including 13 full-length rdhA genes, six truncated rdhA genes, and five rdhA genes having cognate rdhB genes were consistently detected during the dechlorination of all three of the polychlorinated alkanes tested. Transcripts from all four of the putative regulatory genes were also consistently detected. Results reported here expand the diversity of bacteria known to simultaneously transcribe multiple rdh genes and provide insights into the transcription factors associated with rdh gene expression.

  8. BRCA1/2-negative hereditary triple-negative breast cancers exhibit BRCAness.

    Science.gov (United States)

    Domagala, Pawel; Hybiak, Jolanta; Cybulski, Cezary; Lubinski, Jan

    2017-04-01

    BRCA1/2-associated breast cancers are sensitive to poly(ADPribose) polymerase (PARP) inhibitors and platinum compounds mainly due to their deficiency in DNA repair via homologous recombination (HR). However, approximately only 15% of triple-negative breast cancers (TNBCs) are BRCA1/2-associated. TNBCs that exhibit BRCAness (a phenotype reflecting impaired HR in BRCA1/2-negative tumors) are also regarded sensitive to PARP inhibitors and platinum compounds. Thus, we hypothesized that hereditary BRCA1/2-negative TNBCs may exhibit BRCAness. To find a subset of hereditary BRCA1/2-negative TNBCs among 360 TNBCs, we first identified a group of 41 hereditary TNBCs by analyzing the family histories of the patients. Next, we tested this group for the presence of germline BRCA1/2 mutations, and finally, we compared the expression levels of 120 genes involved in HR and five other major mechanisms of DNA damage repair between BRCA1/2-associated and BRCA1/2-negative subgroups of hereditary TNBCs using real-time PCR arrays. Approximately 73% of the hereditary TNBCs were BRCA1/2-associated and 27% were BRCA1/2-negative. The expression levels of the analyzed genes showed no significant differences between these two subgroups indicating the BRCAness of the BRCA1/2-negative hereditary TNBCs and thereby distinguishing a novel subset of TNBCs as a potential target for PARP inhibitors or platinum-based therapy. The results show the significance of family history in selecting patients with TNBC for therapies directed at incompetent DNA repair (e.g., PARP inhibitors and/or platinum-based therapies) and indicate that a relatively simple strategy for broadening the target group for these modes of treatment is to identify patients with hereditary TNBCs.

  9. L1/2 regularization: a thresholding representation theory and a fast solver.

    Science.gov (United States)

    Xu, Zongben; Chang, Xiangyu; Xu, Fengmin; Zhang, Hai

    2012-07-01

    The special importance of L1/2 regularization has been recognized in recent studies on sparse modeling (particularly on compressed sensing). The L1/2 regularization, however, leads to a nonconvex, nonsmooth, and non-Lipschitz optimization problem that is difficult to solve fast and efficiently. In this paper, through developing a threshoding representation theory for L1/2 regularization, we propose an iterative half thresholding algorithm for fast solution of L1/2 regularization, corresponding to the well-known iterative soft thresholding algorithm for L1 regularization, and the iterative hard thresholding algorithm for L0 regularization. We prove the existence of the resolvent of gradient of ||x||1/2(1/2), calculate its analytic expression, and establish an alternative feature theorem on solutions of L1/2 regularization, based on which a thresholding representation of solutions of L1/2 regularization is derived and an optimal regularization parameter setting rule is formulated. The developed theory provides a successful practice of extension of the well- known Moreau's proximity forward-backward splitting theory to the L1/2 regularization case. We verify the convergence of the iterative half thresholding algorithm and provide a series of experiments to assess performance of the algorithm. The experiments show that the half algorithm is effective, efficient, and can be accepted as a fast solver for L1/2 regularization. With the new algorithm, we conduct a phase diagram study to further demonstrate the superiority of L1/2 regularization over L1 regularization.

  10. Structural and electrical properties of Gd(Ni{sub 1/2}Zr{sub 1/2})O{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Nishant [Department of Physics, T.M. Bhagalpur University, Bhagalpur 812007 (India); Dutta, Alo, E-mail: alo_dutta@yahoo.com [Department of Physics, Bose Institute, 93/1, Acharya Prafulla Chandra Road, Kolkata 700009 (India); Prasad, S. [Department of Physics, T.M. Bhagalpur University, Bhagalpur 812007 (India); Sinha, T.P. [Department of Physics, Bose Institute, 93/1, Acharya Prafulla Chandra Road, Kolkata 700009 (India)

    2012-01-15

    Highlights: > The Gd(Ni{sub 1/2}Zr{sub 1/2})O{sub 3} (GNZ) ceramic is synthesized by the solid-state reaction technique. > Frequency dependence dielectric dispersion is studied in a wide temperature range. > Activation energy of 1.1 eV indicates hopping of ions and may be responsible for the dielectric relaxation. > The frequency dependent conductivity spectra follow the power law. - Abstract: The Gd(Ni{sub 1/2}Zr{sub 1/2})O{sub 3} (GNZ) ceramic is synthesized by the solid-state reaction technique. The X-ray diffraction pattern of the sample shows monoclinic phase at room temperature. The dielectric dispersion of the material is investigated in the temperature range from 303 K to 673 K and in the frequency range from 100 Hz to 1 MHz. The relaxation peak is observed in the frequency dependence of the loss tangent. The relaxation time at different temperatures is found to obey Arrhenius law having activation energy of 1.1 eV which indicates the hopping of ions at the lattice site and may be responsible for the dielectric relaxation of GNZ. The scaling behaviour of loss tangent suggests that the relaxation mechanism is temperature independent. The frequency dependent conductivity spectra follow the power law. In the impedance formalism, the Cole-Cole model is used to study the relaxation mechanism of GNZ.

  11. Impedance and a.c. conductivity studies of Ba(Pr1/2Nb1/2)O3 ceramic

    Indian Academy of Sciences (India)

    K Amar Nath; K Prasad; K P Chandra; A R Kulkarni

    2013-08-01

    Impedance and electrical conduction studies of Ba(Pr1/2Nb1/2)O3 ceramic prepared through conventional ceramic fabrication technique are presented. The crystal symmetry, space group and unit cell dimensions were estimated using Rietveld analysis. X-ray diffraction analysis indicated the formation of a single-phase cubic structure with space group, $\\bar{3}$. EDAX and SEM studies were carried out to study the quality and purity of compound. To find a correlation between the response of the real system and idealized model circuit composed of discrete electrical components, the model fittings were presented using impedance data. Complex impedance as well as electric modulus analyses suggested dielectric relaxation to be of non-Debye type and negative temperature coefficient of resistance character. The correlated barrier hopping model was employed to successfully explain the mechanism of charge transport in Ba(Pr1/2Nb1/2)O3. The a.c. conductivity data were used to evaluate density of states at Fermi level, minimum hopping length and apparent activation energy.

  12. Low-dose radiation activates Nrf1/2 through reactive species and the Ca(2+)/ERK1/2 signaling pathway in human skin fibroblast cells.

    Science.gov (United States)

    Lee, Eun Kyeong; Kim, Jin-Ah; Park, Seong Joon; Kim, Jeung Ki; Heo, Kyu; Yang, Kwang Mo; Son, Tae Gen

    2013-05-01

    In the current study, we explored the effect of LDR on the activation of Nrfs transcription factor involved in cellular redox events. Experiments were carried out utilizing 0.05 and 0.5 Gy X-ray irradiated normal human skin fibroblast HS27 cells. The results showed LDR induced Nrf1 and Nrf2 activation and expression of antioxidant genes HO-1, Mn-SOD, and NQO1. In particular, 0.05 Gy-irradiation increased only Nrf1 activation, but 0.5 Gy induced both Nrf1 and Nrf2 activation. LDR-mediated Nrf1/2 activation was accompanied by reactive species (RS) generation and Ca(2+) flux. This effect was abolished in the presence of N-acetyl-cysteine and BAPTA- AM. Furthermore, Nrf1/2 activation by LDR was suppressed by PD98059, an inhibitor of ERK1/2. In conclusion, LDR induces Nrf1 and Nrf2 activation and expression of Nrf-regulated antioxidant defense genes through RS and Ca(2+)/ERK1/2 pathways, suggesting new insights into the molecular mechanism underlying the beneficial role of LDR in HS27 cells.

  13. Structural and dielectric studies of lead-free ceramics: Na1/2Y1/2TiO3

    Science.gov (United States)

    Barik, Subrat; Choudhary, Ram; Mahapatra, Prasanta

    2008-12-01

    The polycrystalline samples of Na1/2Y1/2TiO3 were prepared by the mixed-oxide method. A preliminary X-ray structural analysis was shown to exhibit the formation of a single-phase compound with an orthorhombic structure. Microstructural analysis by scanning electron microscopy (SEM) exhibits well defined grains distributed uniformly through out the sample suggesting the compactness and homogeneity of the sample. Detailed studies of dielectric properties of Na1/2Y1/2TiO3 in a wide frequency range (102-106 Hz) at different temperatures (31-500°C) show a dielectric anomaly at 105°C, which may be related to a ferroelectricparaelectric phase transition as suggested by hysteresis loop at room temperature. An ac conductivity (σ ac) of the material is mainly governed by the polaron hopping mechanism, which is also influenced by both frequency and temperature. The activation energy was obtained from the plot of temperature with a.c. conductivity.

  14. Measurement of the scalar polarizability within the 5P1/2-6S1/2, 410 nm transition in atomic indium

    CERN Document Server

    Ranjit, G; Lorenzo, A T; Schneider, A E; Majumder, P K

    2013-01-01

    We have completed a new measurement of the Stark shift in 115In within the 410 nm 5P1/2- 6S1/2 transition. We measure the Stark shift constant to be kS= - 122.92(33)kHz/(kV/cm)^2, corresponding to a difference in the 6S1/2 and 5P1/2 state polarizabilities, \\Delta\\alpha_0, of 1000.2 (2.7) a.u.(in atomic units). This result is a factor of 30 more precise than previous measurements and is in excellent agreement with a new theoretical value based on an ab initio calculation of the wave functions in this three-valence-electron system. The measurement was performed in an indium atomic beam apparatus, used a GaN laser diode system, and exploited an FM spectroscopy technique to extract laser transmission spectra under conditions where our interaction region optical depth was typically less than 10^-3.

  15. Synthesis of cyclic nitrone and 1,2-oxazine from 1,2,4-triaryl-but-2-ene-1,4-dione and hydroxylamine

    Indian Academy of Sciences (India)

    Muthupandi Nagaraj; Murugan Iniya; Muthusamy Boominathan; Shanmugam Muthusubramanian; Nattamai Bhuvanesh

    2012-07-01

    The reaction of hydroxylamine hydrochloride with differently substituted phenyldibenzoylethylene has been investigated. Both cyclic nitrone and 1,2-oxazine have been isolated and characterized by one- and two-dimensional NMR data and also by single crystal X-ray analysis.

  16. [Research of imidazo[1,2-a]benzimidazole derivatives. XXX. Synthesis and properties of (imidazo[1,2-a]benzimidazolyl-2)acetic acid derivatives].

    Science.gov (United States)

    Anisimova, V A; Tolpygin, I E; Spasov, A A; Serdiuk, T S; Sukhov, A G

    2011-01-01

    Ethyl esters of (9-subtituted-imidazo[1,2-a]benzimidazolyl-2)acetic acids were synthesized. The chemical properties of these esters (hydrolysis, decarboxylation, hydrazinolysis) and biological activity (fungicidal, antimicrobial, antiarrhythmic activity, and also affects on the brain rhythmogenesis) of the prepared compounds were studied.

  17. Formation of ultracold LiRb molecules by photoassociation near the Li(2s 2S1/2) + Rb(5p 2P1/2) asymptote

    Science.gov (United States)

    Dutta, Sourav; Elliott, Daniel S.; Chen, Yong P.

    2013-12-01

    We report the production of ultracold 7Li85Rb molecules by photoassociation (PA) below the Li (2s 2S1/2) + Rb(5p 2P1/2) asymptote. We perform PA spectroscopy in a dual-species 7Li-85Rb magneto-optical trap (MOT) and detect the PA resonances using trap loss spectroscopy. We observe several strong PA resonances corresponding to the last few bound states, assign the lines and derive the long-range C6 dispersion coefficients for the Li (2s 2S1/2) + Rb(5p 2P1/2) asymptote. We also report an excited-state molecule formation rate (P_{\\textit{LiRb}}) of {\\sim}10^{7}\\ \\text{s}^{-1} and a PA rate coefficient (K_{PA}) of {\\sim}4\\times10^{-11}\\ \\text{cm}^3/\\text{s} , which are both among the highest observed for heteronuclear bi-alkali molecules. These suggest that PA is a promising route for the creation of ultracold ground-state LiRb molecules.

  18. Formation of ultracold LiRb molecules by photoassociation near the Li (2s 2S1/2) + Rb (5p 2P1/2) asymptote

    CERN Document Server

    Dutta, Sourav; Chen, Yong P

    2013-01-01

    We report the production of ultracold 7Li85Rb molecules by photoassociation (PA) below the Li (2s 2S1/2) + Rb (5p 2P1/2) asymptote. We perform PA spectroscopy in a dual-species 7Li-85Rb magneto-optical trap (MOT) and detect the PA resonances using trap loss spectroscopy. We observe several strong PA resonances corresponding to the last few bound states, assign the lines and derive the long range C6 dispersion coefficients for the Li (2s 2S1/2) + Rb (5p 2P1/2) asymptote. We also report an excited-state molecule formation rate (P_LiRb) of ~10^7 s^-1 and a PA rate coefficient (K_PA) of ~4x10^-11 cm^3/s, which are both among the highest observed for heteronuclear bi-alkali molecules. These suggest that PA is a promising route for the creation of ultracold ground state LiRb molecules.

  19. Original Reaction Sequence of Pb(Yb1/2Nb1/2O3-PbTiO3: Consequences on Dielectric Properties and Chemical Order

    Directory of Open Access Journals (Sweden)

    Charlotte Cochard

    2015-01-01

    Full Text Available The solid solution [Pb(Yb1/2Nb1/2O3]1−x-[PbTiO3]x was synthesized with x≤60%, using several high-temperature techniques as well as room-temperature mechanosynthesis. The high-temperature synthesis reveals a reaction path involving the synthesis first of the end-members before the solid solution. The density and dielectric constant measured on the ceramics prepared from these powders indicate the crucial role of the synthesis technique in the subsequent properties. Mechanosynthesis results in ceramics with higher density and dielectric constant. Identical optimized sintering conditions were then applied to all investigated compositions and the resulting dielectric properties and chemical orders were compared. All polar orders (antiferroelectricity, ferroelectricity, and relaxor behavior were evidenced. The 1 : 1 chemical order on the B-site of Pb(Yb1/2Nb1/2O3 results in the formation of a double perovskite Pb2YbNbO6, and the superstructures in the X-ray diagrams signing the existence of this order persist up to 30% PbTiO3. The underlying mechanism for substitution of Yb or Nb by Ti is presented.

  20. Preparation of 1,1'-dinitro-3,3'-azo-1,2,4-triazole. [1,1'-dinitro-3,3'-azo-1,2,4-triazole

    Science.gov (United States)

    Lee, K.Y.

    1985-03-05

    A new high density composition of matter, 1,1'-dinitro-3,3'-azo-1,2,4-triazole, has been synthesized using inexpensive, commonly available compounds. This compound has been found to be an explosive, and its use as a propellant is anticipated. 1 fig., 1 tab.

  1. Western blot seroindeterminate individuals for Human T-lymphotropic Virus 1/2 (HTLV-1/2 in Fortaleza (Brazil: a serological and molecular diagnostic and epidemiological approach

    Directory of Open Access Journals (Sweden)

    Terezinha de Jesus Teixeira Santos

    2003-06-01

    Full Text Available How to handle Western blot (WB seroindeterminate individuals for Human T-lymphotropic Virus 1/2 (HTLV-1/2 constitutes a challenge for blood banks and fam ilies. We made a cross-sectional study of 191 enzyme linked immunoassay (EIA reactive individuals from the hematological center (HEMOCE of Fortaleza (Brazil, examining their serological (WB and molecular (PCR diagnosis, and demographic profiles, as well as a possible association of their condition with other infectious pathologies and risk factors. Ethical institutional approval and personal consent were obtained. Out of 191 EIA reactive individuals, 118 were WB seroindeterminate and 73 were seropositive for HTLV-1/2. In the PCR analysis of 41 WB seroindeterminate individuals, 9 (22% were positive and 32 (78% were negative for HTLV-1/2. The demographic analysis indicated a trend towards a predominance of males among the seroindeterminate individuals and females in the seropositive ones. The seroindeterminate individuals were younger than the seropositive ones. We did not find any association of these conditions with syphilis, Chagas disease or HIV or hepatitis, and with risk factors such as breast-feeding, blood transfusion, STD (syphilis and IDU.

  2. 合成1,2-环十二二酮的新方法%A Novel Synthetic Method of 1,2-Cyclododecandione

    Institute of Scientific and Technical Information of China (English)

    陈韶蕊; 马吉海; 周雪琴; 刘东志

    2009-01-01

    1,2-Cyclododecandione (4) was synthesized from dodecanedioic acid via esterification, acyloin condensation, oxidation in an overall yield of 43. 1 %. Reaction of dodecanedioic acid with methanol gave dodecanedioic acid dimethyl ester(2) with a yield of 86. 5%. Compound 3 was obtained from compound 2 through acyloin condensation and the yield reached up to 63. 1% , which was oxidized to compound 4 by bromine water as the oxidation reagent with a yield of 79%. The target compound was a light yellow crystal and was characterized by means of IR, ~1H NMR and ~(I3)C NMR.%以十二烷二酸(1)为原料,与甲醇酯化生成十二烷二酸二甲酯(2),收率为86.5%.化合物2经偶联缩合得1,2-二三甲基硅氧基环十二烯(3),收率为63.1%. 利用溴氧化化合物3得到1,2-环十二二酮(4)淡黄色晶体,收率79%,全过程收率达43.1%,是合成1,2-二酮的新方法. 目标化合物结构经红外光谱、核磁共振氢谱和碳谱表征确认.

  3. Fragmento 1+2 da protrombina em indivíduos submetidos à angiografia coronariana Prothrombin fragment 1+2 in subjects undergoing coronary angiography

    Directory of Open Access Journals (Sweden)

    Luciana M. Lima

    2005-09-01

    Full Text Available A trombina exerce um papel fundamental na conversão do fibrinogênio em fibrina, no processo de coagulação. O fator X ativado transforma a protrombina em trombina e fragmento 1+2 da protrombina (F1+2. Os níveis plasmáticos de F1+2 refletem a geração de trombina e podem ser usados como um marcador de hipercoagulabilidade in vivo, já que a trombina é uma substância instável e facilmente degradada, que não pode ser medida diretamente no plasma. O presente estudo teve como objetivo determinar os níveis plasmáticos do F1+2 de um grupo de indivíduos submetidos à angiografia coronariana, buscando estabelecer a possível correlação entre este parâmetro e a gravidade da doença arterial coronariana (DAC. Os níveis plasmáticos do F1+2 foram determinados em amostras de sangue de 17 indivíduos com ausência de ateromatose nas coronárias (controles, 12 indivíduos apresentando ateromatose leve/moderada e 28 indivíduos apresentando ateromatose grave, utilizando-se o conjunto diagnóstico Enzignost F1+2 (Behring® Diagnostics GmbH, Marburg, Germany. Não foram encontradas diferenças estatisticamente significativas entre as médias dos três grupos para o parâmetro avaliado. Portanto, as médias obtidas nos três grupos para os níveis plasmáticos de F1+2 não sinalizam para a existência de um estado de hipercoagulabilidade na população estudada. Entretanto, 73,7% dos indivíduos faziam uso regular de ácido acetilsalicílico, o que pode ter influenciado nos resultados de F1+2, uma vez que este medicamento promove a inibição da enzima ciclooxigenase, diminuindo a liberação de tromboxane A2 e a agregação plaquetária. Portanto, presume-se que a redução da ativação plaquetária poderia estar contribuindo para uma menor formação de trombina e, conseqüentemente, diminuindo o potencial de hipercoagulabilidade.Thrombin plays a basic role in the conversion of fibrinogen to fibrin in the coagulation process. Activated factor X

  4. Purification and characterization of an alcohol dehydrogenase from 1,2-propanediol-grown Desulfovibriostrain HDv

    NARCIS (Netherlands)

    Hensgens, Charles M.H.; Jansen, Michael; Nienhuis-Kuiper, Manny E.; Boekema, Egbert J.; Breemen, Jan F.L. van; Hansen, Theo A.

    1995-01-01

    The sulfate-reducing bacterium Desulfovibrio strain HDv (DSM 6830) grew faster on (S)- and on (R, S)-1,2-propanediol (µmax 0.053 h–1) than on (R)-propanediol (0.017 h–1) and ethanol (0.027 h–1). From (R, S)-1,2-propanediol-grown cells, an alcohol dehydrogenase was purified. The enzyme was

  5. Detection and identification of Actinobacillus pleuropneumoniae serotypes 1, 2, and 8 by multiplex PCR

    DEFF Research Database (Denmark)

    Schuchert, J.A.; Inzana, T.J.; Angen, Øystein

    2004-01-01

    Multiplex PCR assays were developed to identify Actinobacillus pleuropneumoniae serotypes 1, 2, and 8. Primers designed for the conserved capsular polysaccharide (CP) export region amplified a 489-bp DNA fragment from all serotypes. Primers specific to the CP biosynthesis regions of serotypes 1, 2...

  6. Degradation of 1,2-Dibromoethane by Mycobacterium sp. Strain GP1

    NARCIS (Netherlands)

    Poelarends, Gerrit J.; Hylckama Vlieg, Johan E.T. van; Marchesi, Julian R.; Freitas dos Santos, Luisa M.; Janssen, Dick B.

    1999-01-01

    The newly isolated bacterial strain GP1 can utilize 1,2-dibromoethane as the sole carbon and energy source. On the basis of 16S rRNA gene sequence analysis, the organism was identified as a member of the subgroup which contains the fast-growing mycobacteria, The first step in 1,2-dibromoethane metab

  7. Novel Platinum Catalyzed Glycosylation Using 1,2-Cyclopropanated Sugars as Glycosyl Donors

    DEFF Research Database (Denmark)

    Beyer, Jürgen; Madsen, Robert

    1998-01-01

    By treating 1,2-cyclopropanated sugars with Zeise's dimer and an alcohol a regioselective ring opening of the cyclopropane takes place to give 2-C-alkyl-2-deoxy-glycosides......By treating 1,2-cyclopropanated sugars with Zeise's dimer and an alcohol a regioselective ring opening of the cyclopropane takes place to give 2-C-alkyl-2-deoxy-glycosides...

  8. Metallothionein-1+2 protect the CNS after a focal brain injury

    DEFF Research Database (Denmark)

    Giralt, Mercedes; Penkowa, Milena; Lago, Natalia;

    2002-01-01

    We have evaluated the physiological relevance of metallothionein-1+2 (MT-1+2) in the CNS following damage caused by a focal cryolesion onto the cortex. In comparison to normal mice, transgenic mice overexpressing the MT-1 isoform (TgMTI* mice) showed a significant decrease of the number of activa...

  9. Deliverable 1.2.7: Cross-cultural benefit segmentation of consumers

    NARCIS (Netherlands)

    Reinders, M.J.; Onwezen, M.C.; Sijtsema, S.J.; Zimmermann, K.L.; Berg, van den I.; Jasiulewicz, A.; Guardia, M.D.; Guerrero, L.

    2010-01-01

    The present report, deliverable D.1.2.7, gives a final view of the work done in ISAFruit Work Package (WP) 1.2. Average Europe fruit consumption is below the recommended level and moreover the consumption level is still decreasing in Europe. A large survey was carried out in four European countries

  10. Metallothionein 1+2 protect the CNS during neuroglial degeneration induced by 6-aminonicotinamide

    DEFF Research Database (Denmark)

    Penkowa, Milena; Giralt, Mercedes; Camats, Jordi

    2002-01-01

    6-Aminonicotinamide (6-AN) is a niacin antagonist, which leads to degeneration of gray matter astrocytes. Metallothionein 1+2 (MT-1+2) are neuroprotective factors in the central nervous system (CNS), and to determine the roles for MT after 6-AN, we have examined transgenic mice overexpressing MT-1...

  11. 40 CFR 721.3807 - Formaldehyde, polymer with phenol and 1,2,3-propanetriol, methylated.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Formaldehyde, polymer with phenol and... Significant New Uses for Specific Chemical Substances § 721.3807 Formaldehyde, polymer with phenol and 1,2,3... chemical substance identified as formaldehyde, polymer with phenol and 1,2,3-propanetriol, methylated...

  12. Quantization of the AdS3 superparticle on OSP (1 | 2) 2 / SL (2 , R)

    Science.gov (United States)

    Heinze, Martin; Jorjadze, George

    2017-02-01

    We analyze AdS3 superparticle dynamics on the coset OSP (1 | 2) × OSP (1 | 2) / SL (2 , R). The system is quantized in canonical coordinates obtained by gauge invariant Hamiltonian reduction. The left and right Noether charges of a massive particle are parametrized by coadjoint orbits of a timelike element of osp (1 | 2). Each chiral sector is described by two bosonic and two fermionic canonical coordinates corresponding to a superparticle with superpotential W = q - m / q, where m is the particle mass. Canonical quantization then provides a quantum realization of osp (1 | 2) ⊕ osp (1 | 2). For the massless particle the chiral charges lie on the coadjoint orbit of a nilpotent element of osp (1 | 2) and each of them depends only on one real fermion, which demonstrates the underlying κ-symmetry. These remaining left and right fermionic variables form a canonical pair and the system is described by four bosonic and two fermionic canonical coordinates. Due to conformal invariance of the massless particle, the osp (1 | 2) ⊕ osp (1 | 2) extends to the corresponding superconformal algebra osp (2 | 4). Its 19 charges are given by all real quadratic combinations of the canonical coordinates, which trivializes their quantization.

  13. 26 CFR 1.412(c)(1)-2 - Shortfall method.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Shortfall method. 1.412(c)(1)-2 Section 1.412(c... (CONTINUED) INCOME TAXES Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.412(c)(1)-2 Shortfall method. (a) In general—(1) Shortfall method. The shortfall method is a funding method that adapts a...

  14. 78 FR 79007 - 1,1,1,2-Tetrafluoroethane From China

    Science.gov (United States)

    2013-12-27

    ... the notice in the Federal Register of October 28, 2013 (78 FR 64243). The conference was held in... COMMISSION 1,1,1,2-Tetrafluoroethane From China Determinations On the basis of the record \\1\\ developed in... reason of imports from China of 1,1,1,2- Tetrafluoroethane, provided for in subheadings 2903.39.20 of...

  15. Palladium-catalyzed regioselective arylation of imidazo[1,2-a]pyrimidine.

    Science.gov (United States)

    Li, Wenjie; Nelson, Dorian P; Jensen, Mark S; Hoerrner, R Scott; Javadi, Gary J; Cai, Dongwei; Larsen, Robert D

    2003-12-11

    Imidazo[1,2-a]pyrimidine can be arylated at the 3-position with aryl bromides in the presence of base and a catalytic amount of palladium. This provides an efficient one-step synthesis of 3-arylimidazo[1,2-a]pyrimidines from the unsubstituted heterocycle. [reaction: see text

  16. Tandem Amine Propargylation-Huisgen Cycloaddition to Functionalized Substituted 1,2,3-Triazoles

    Institute of Scientific and Technical Information of China (English)

    WANG,Peng; ZHAO,Ya-Bin; LIANG,Yong-Ming

    2004-01-01

    @@ The chemistry of 1,2,3-triazoles has received much attention because of their wide range applications.[1] They have been used as fungicides, herbicides, light stabilizers, fluorescent whiteners, optical brightening agents. Therefore, it is important to develop new and more efficient synthetic pathways to a diverse array of 1,2,3-triazoles.

  17. CaV1.2 calcium channels: just cut out to be regulated?

    Science.gov (United States)

    Groth, Rachel D; Tirko, Natasha N; Tsien, Richard W

    2014-06-04

    Tight regulation of calcium entry through the L-type calcium channel CaV1.2 ensures optimal excitation-response coupling. In this issue of Neuron, Michailidis et al. (2014) demonstrate that CaV1.2 activity triggers negative feedback regulation through proteolytic cleavage of the channel within the core of the pore-forming subunit.

  18. Canonical osp(1,2) quantization of dynamical systems with constraints

    CERN Document Server

    Lavrov, P M; Oliveira, W; Lavrov, Petr M.; Neto, Jorge Ananias; Oliveira, Wilson

    1998-01-01

    The canonical version of osp(1,2) quantization is formulated for arbitrary dynamical systems with first-class constraints. The formalism generalizes the canonical scheme of extended BRST quantization proposed by Batalin, Lavrov and Tyutin a few years ago. The gauge dependence of Green's functions is studied. The Ward identities related to the osp(1,2) symmetry are derived.

  19. Discovery and characterization of thermophilic limonene-1,2-epoxide hydrolases from hot spring metagenomic libraries

    DEFF Research Database (Denmark)

    Ferrandi, Erica Elisa; Sayer, Christopher; Isupov, Michail N.;

    2015-01-01

    The epoxide hydrolases (EHs) represent an attractive option for the synthesis of chiral epoxides and 1,2-diols which are valuable building blocks for the synthesis of several pharmaceutical compounds. A metagenomic approach has been used to identify two new members of the atypical EH limonene-1,2...

  20. Genaesthics : Breast Surgery in BRCA1/2 Gene Mutation Carriers

    NARCIS (Netherlands)

    V.M.T. van Verschuer (Victorien)

    2017-01-01

    markdownabstractThe present thesis focuses on breast surgery in BRCA1/2 gene mutation carriers. The topics that are studied vary broadly, representing the multiple disciplines that are involved in the diagnostic work-up and treatment of BRCA1/2-associated breast cancer. The first part contains

  1. Deliverable 1.2.7: Cross-cultural benefit segmentation of consumers

    NARCIS (Netherlands)

    Reinders, M.J.; Onwezen, M.C.; Sijtsema, S.J.; Zimmermann, K.L.; Berg, van den I.; Jasiulewicz, A.; Guardia, M.D.; Guerrero, L.

    2010-01-01

    The present report, deliverable D.1.2.7, gives a final view of the work done in ISAFruit Work Package (WP) 1.2. Average Europe fruit consumption is below the recommended level and moreover the consumption level is still decreasing in Europe. A large survey was carried out in four European countries

  2. 75 FR 13327 - Tennessee Valley Authority; Browns Ferry Nuclear Plant, Units 1, 2, and 3; Exemption

    Science.gov (United States)

    2010-03-19

    ... COMMISSION Tennessee Valley Authority; Browns Ferry Nuclear Plant, Units 1, 2, and 3; Exemption 1.0... DPR-33, DPR-52 and DPR-68, which authorize operation of the Browns Ferry Nuclear Plant, Units 1, 2... Ferry Schedule Exemption Request The licensee provided detailed information in its November 6, 2009...

  3. Alternative biological sources for 1,2,3,4-tetramethylbenzene in flash pyrolysates of kerogen

    NARCIS (Netherlands)

    Sinninghe Damsté, J.S.; Hoefs, M.J.L.; Heemst, J.D.H. van; Gelin, F.; Koopmans, M.P.; Kaam-Peters, H.M.E. van; Schouten, S.; Leeuw, J.W. de

    1995-01-01

    Pyrolysates of kerogens isolated from Indian Ocean surface sediments and from Black Sea Unit II contain abundant 1,2,3,4-tetramethylbenzene (1,2,3,4-TMB) suggesting the presence of macromolecularly-bound isorenieratane skeletons derived from isorenieratene biosynthesized by green sulphur bacteria

  4. Multicentric evaluation of a new assay for prothrombin fragment F1+2 determination.

    Science.gov (United States)

    Bruhn, H D; Conard, J; Mannucci, M; Monteagudo, J; Pelzer, H; Reverter, J C; Samama, M; Tripodi, A; Wagner, C

    1992-10-01

    A multicenter study of a recently developed ELISA for the determination of prothrombin fragment F1+2 was performed in order to evaluate analytical and clinical aspects. Mean intra-assay and inter-assay reproducibility were found to be 11.0 and 12.6%, respectively. The measuring range covered by the calibration curve reaches from 0.04 to 10.0 nM/l F1+2. Testing 133 healthy subjects a reference range of 0.37 to 1.11 nM/l F1+2 (2.5-97.5 percentile) with a median of 0.66 nM/l F1+2 was calculated. Minor difficulties with blood sampling (venous occlusion for 2 min) did not affect F1+2 plasma concentrations. Significantly increased F1+2 levels were measured in patients with leukemia (p < 0.0001), severe liver disease (p < 0.005) and after myocardial infarction (p < 0.01). Elevated F1+2 concentration before the beginning of heparin therapy (1.25 nM/l) decreased to 0.77 nM/l (p < 0.0001) after 1 day of therapy. For patients in the stable phase of oral anticoagulant therapy decreasing F1+2 concentrations were measured with increasing INR. F1+2 levels were already significantly reduced in patients with INR < 2.0 (0.56 nM/l; p = 0.0005). Thus F1+2 determination may be helpful in identifying activation processes as well as in monitoring anticoagulant therapy.

  5. Eight paths of ERK1/2 signalling pathway regulating hepatocyte proliferation in rat liver regeneration

    Indian Academy of Sciences (India)

    J. W. Li; G. P. Wang; J. Y. Fan; C. F. Chang; C. S. Xu

    2011-12-01

    Although it is known that hormones, growth factors and integrin promote hepatocyte proliferation in liver regeneration (LR) through ERK1/2 signalling pathway, reports about regulating processes of its intracellular paths in hepatocytes of LR are limited. This study aims at exploring which paths of ERK1/2 signalling pathway participate in the regulation of rat LR, especially in hepatocyte proliferation, and how they do so. In all, 14 paths and 165 genes are known to be involved in ERK1/2 signalling pathway. Of them, 161 genes are included in Rat Genome 230 2.0 Array. This array was used to detect expression changes of genes related to ERK1/2 signalling pathway in isolated hepatocytes of rat LR, showing that 60 genes were related to hepatocytes of LR. In addition, bioinformatics and systems biology methods were used to analyse the roles of 14 above paths in regenerating hepatocytes. We found that three paths, RTK → SHC → GRB2/SOS → RAS → RAF, Integrin → FAK → RAC → PAK → RAF and G → PI3K → RAC → PAK → RAF, promoted the G1 phase progression of hepatocytes by activating ERK1/2. A further four paths, Gq → PLC → PKC → SRC/PYK2 → GRB2/SOS → RAS → RAF, RTK → PLC → PKC → SRC/PYK2 → GRB2/SOS → RAS → RAF, Integrin → FAK/SRC → GRB2/SOS → RAS → RAF and Integrin → FAK → RAC → PAK → RAF, advanced the cell progression of S phase and G2/M checkpoint by activating ERK1/2, and so did PP1/2 → Mek1/2 by decreasing the negative influence on ERK1/2. At the late phase of LR, Gs → AC → EPAC → Rap1 → Raf blocked hepatocyte proliferation by decreasing the activity of ERK1/2 and so did PP1/2 → Mek1/2. In summary, 60 genes and 8 paths of ERK1/2 signalling pathway regulated hepatocyte proliferation in rat LR.

  6. Adsorption structure, thermal reaction and initial pathways of 1,2-benzyne on Cu(100)

    Science.gov (United States)

    Lin, Jong-Liang; Lin, Yi-Shiue; Lin, Bo-Chiuan; Liao, Yuan-Hsuan; Chen, Yi-Ting; Chen, Shang-Wei; Jhuang, Jyun-Yi; Lee, Yarong; Lin, Jiing-Chyuan

    2016-10-01

    1,2-C6H4I2 is used as precursor to generate 1,2-C6H4 (ortho-C6H4) on Cu(100). The reflection-absorption infrared spectroscopy (RAIRS) confirms the vertical adsorption geometry of 1,2-C6H4 on Cu(100), which agrees with that predicted theoretically. H2 evolving between 620 K and 870 K is the only reaction product detected from the 1,2-C6H4 decomposition in temperature-programmed reaction/desorption (TPR/D). Our calculations indicate that the 1,2-C6H4 primarily undergoes C3-H bond scission, forming 1,2,3-C6H3, with distorted C6 ring, and H atom on the surface without ring rupture (C1-C2 bond dissociation) prior to H loss. Furthermore, isomerization of the 1,2-C6H4, if it does occur, may proceed via dehydrogenation-hydrogenation, instead of H-shift.

  7. Características produtivas e reprodutivas de fêmeas da raça Nelore e cruzadas 1/2 Canchim + 1/2 Nelore Productive and reproductive traits of straightbred Nellore and crossbred 1/2 Canchim + 1/2 Nellore Females

    Directory of Open Access Journals (Sweden)

    Alencar

    1999-01-01

    Full Text Available O objetivo deste estudo foi avaliar os efeitos de fatores de meio e genéticos sobre o peso ao parto (PVP de vacas Nelore e 1/2 Canchim + 1/2 Nelore, acasaladas com touros das raças Canchim e Charolesa, respectivamente, e também sobre o período de gestação (PG de seus bezerros e sobre os pesos (P e as idades (I à primeira inseminação (PI, primeira concepção (PC e primeira parição (PP das novilhas 1/2Canchim + 1/2 Nelore. O método dos quadrados mínimos foi usado com modelos matemáticos que incluíram os efeitos de ano e mês do parto, idade da vaca ao parto e origem da vaca (para as vacas Nelore para a análise de PVP, estação de monta, idade da vaca, origem da vaca, sexo do bezerro e os efeitos aleatórios de pai do bezerro, para a análise de PG, e ano e época de nascimento e a interação ano x época, para as características das novilhas. Ano do parto e origem da vaca apresentaram efeito sobre PVP. As vacas paridas de agosto a novembro foram mais leves ao parto que as paridas em dezembro e de maio a julho. O peso ao parto aumentou linearmente com a idade da vaca. O PG dos machos foi maior que o das fêmeas, para os bezerros 1/2 Canchim + 1/2 Nelore. As médias estimadas de PVP foram iguais a 450±2 kg (vacas Nelore e 502±2 kg (vacas 1/2 Canchim + 1/2 Nelore e as de PG, 291,0 ± 0,4 dias (bezerros 1/2 Canchim + 1/2 Nelore e 285,7± 0,2 dias (bezerros 1/2 Charolês + 1/4 Canchim + 1/4 Nelore. Para as novilhas cruzadas, as médias estimadas foram iguais a 372±2 kg (PPI, 376±2 kg (PPC, 442±3 kg (PPP, 810±5 dias (IPI, 831±6 dias (IPC e 1116±6 dias (IPP. As herdabilidades de PG, como característica do bezerro, foram iguais a 0,19±0,14 (1/2 Canchim + 1/2 Nelore e 0,69±0,31 (1/2 Charolês + 1/4 Canchim + 1/4 Nelore.The objective of this study was to evaluate the effects of genetic and non genetic factors on cow weight at calving (CWC of Nellore and 1/2 Canchim + 1/2 Nellore cows, mated to Canchim (5/8 Charolais + 3/8 Zebu

  8. Absolute Stereochemistry of 1,2-Diols from Lipids of Thermomicrobia.

    Science.gov (United States)

    Lagutin, Kirill; Wong, Herbert; Vyssotski, Mikhail; MacKenzie, Andrew

    2016-03-01

    1,2-Diol based phospholipids are a well-known feature of bacteria from the class Thermomicrobia. Since these bacteria contain only lipids with an alkyldiol-1-phosphate backbone instead of sn-glycero-3-phosphate, it is important to elucidate the stereochemistry of the 1,2-diols. We have studied the absolute stereochemistry of long-chain 1,2-diols isolated from Thermorudis pharmacophila (formerly known as Thermomicrobia sp. WKT50.2) by nuclear magnetic resonance (NMR) using α-methoxyphenylacetic acid (MPA). Low-temperature (-60 °C) NMR of bis-(R)-MPA ester showed (R) stereochemistry of the 1,2-diols. This is the first report concerning the stereochemistry of natural 1,2-diols, which replace the glyceride moiety in phospholipids. The (R) stereochemistry of the diols is expected as it is the same configuration as for the common bacterial lipid backbone-sn-glycero-3-phosphate. This is the first application of low-temperature NMR of a single MPA derivative for assignment of stereochemistry of natural 1,2-diols. The results were confirmed by the comparison of NMR data with bis-(R)-MPA ester of (R) and rac-1,2-octanediol.

  9. Antimicrobial and cytotoxic activities of 1,2,3-triazole-sucrose derivatives.

    Science.gov (United States)

    Petrova, Krasimira T; Potewar, Taterao M; Correia-da-Silva, Paula; Barros, M Teresa; Calhelha, Ricardo C; Ćiric, Ana; Soković, Marina; Ferreira, Isabel C F R

    2015-11-19

    A library of 1-(1',2,3,3',4,4',6-hepta-O-acetyl-6'-deoxy-sucros-6'-yl)-1,2,3-triazoles have been investigated for their antibacterial, antifungal and cytotoxic activities. Most of the target compounds showed good inhibitory activity against a variety of clinically and food contaminant important microbial pathogens. In particular, 1-(1',2,3,3',4,4',6-hepta-O-acetyl-6'-deoxy-sucros-6'-yl)-4-(4-pentylphenyl)-1,2,3-triazole (5) was highly active against all the tested bacteria with minimal inhibitory concentrations (MICs) ranging between 1.1 and 4.4 µM and bactericidal concentrations (MBCs) from 2.2 and 8.4 µM. The compound 1-(1',2,3,3',4,4',6-hepta-O-acetyl-6'-deoxy-sucros-6'-yl)-4-(4-bromophenyl)-1,2,3-triazole (3) showed antifungal activity with MICs from 0.6 to 4.8 µM and minimal fungicidal concentrations (MFCs) ranging between 1.2 and 8.9 µM. Furthermore, some of the compounds possessed moderate cytotoxicity against human breast, lung, cervical and hepatocellular carcinoma cell lines, without showing toxicity for non-tumor liver cells. The above mentioned derivatives represent promising leads for the development of new generation of sugar-triazole antifungal agents.

  10. Factor analysis of the WISC-R (Spanish version) at 11 age levels between 6 1/2 and 16 1/2 years.

    Science.gov (United States)

    Gass, C S; Demsky, Y I; Martin, P C

    1998-01-01

    The Spanish version of the Wechsler Intelligence Scale for Children-Revised (WISC-R, Wechsler, 1974)-the Escala de Inteligencia para Niños-Revision (EIWN-R, Wechsler, 1982)-has a potentially important role in the assessment of Hispanic children. However, little is known regarding its psychometric characteristics. This study used the normative data from the EIWN-R standardization sample (N = 532 Cuban Americans) to examine its factorial composition and general comparability with the WISC-R. Within each of the 11 age groups (ages 6 1/2 to 16 1/2), the correlation matrix of raw scores was subjected to a principal components analysis and varimax rotation. The results supported a 2-factor solution across age groups roughly corresponding with Wechsler's verbal and performance dimensions. The existence of a meaningful third factor, which has empirical support in the WISC-R literature, failed to emerge for the EIWN-R.

  11. The electrical properties and relaxation behavior of AgNb{sub 1/2}Ta{sub 1/2}O{sub 3} ceramic

    Energy Technology Data Exchange (ETDEWEB)

    Prasad, K.Ganga, E-mail: kotagirigangaprasad@gmail.com; Niranjan, Manish K.; Asthana, Saket

    2017-02-01

    Polycrystalline AgNb{sub 1/2}Ta{sub 1/2}O{sub 3} powder was prepared by solid state reaction method. Preliminary x-ray diffractogram analysis of some aspects of crystal structure showed that a single phase compound formed exhibiting a monoclinic system. Impedance spectroscopy showed the presence of both bulk and grain boundary effects in the material. The relaxation behavior was studied by fitting electric modulus with Bergman function confirms us the existence of non-Debye type of relaxation the material. The ac conductivity spectrum obeyed Funke's double power law and fitting in results, the hopping parameters n{sub 1},n{sub 2} were indicating the existence of small and large range polaron hopping in the material. The band gap of the material 3.02 eV measured by using UV visible spectroscopy.

  12. Energy storage property in lead free gd doped Na1/2Bi1/2TiO3 ceramics

    Science.gov (United States)

    Zannen, Moneim; Lahmar, Abdelilah; Khemakhem, Hamadi; El Marssi, Mimoun

    2016-11-01

    The Effect of Gadolinium ion incorporation on structure, dielectric and ferroelectric properties of lead-free Na1/2Bi1/2TiO3 (NBT) ceramic was investigated. X-ray diffraction allowed the identification of a pure phase isostructural to NBT. Dielectric measurements showed more pronounced anomalies in the range of depolarization temperature when Gd was added. Antiferroelectric-like behavior with a double pinched hysteresis loop was observed versus temperature in the doped phase. The energy-storage density (W) was calculated using the P-E loops data and was found to vary from 0.45 J cm-3 at room temperature to 0.85 J cm-3 at 413 K, which is promising for energy storage application.

  13. Conglomerate formative precursor of chiral drug timolol: 3-(4-Morpholino-1,2,5-thiadiazol-3-yloxy)-propane-1,2-diol

    Science.gov (United States)

    Bredikhin, Alexander A.; Zakharychev, Dmitry V.; Fayzullin, Robert R.; Bredikhina, Zemfira A.; Gubaidullin, Aidar T.

    2015-05-01

    Solid state properties of 3-(4-N-morpholino-1,2,5-thiadiazol-3-yloxy)-propane-1,2-diol 3, the synthetic precursor of popular drug timolol, have been investigated. The original solubility test, the data of X-ray diffraction and DSC methods indicate that the compound is prone to spontaneous resolution. Diol 3 crystallizing from both enantiopure or racemic feed material forms "guaifenesin-like" crystal packing in which the classic H-bonded bilayers, framed in both sides by hydrophobic molecular fragments, act as the basic supramolecular motif. The main chain conformation of the molecules in the crystals of diol 3 differs from that in the guaifenesin crystals, and this fact changes the absolute configuration of spiral columns formed by intermolecular hydrogen bonds in crystals of 3 as compared with guaifenesin crystals.

  14. Di-ionizable p-tert-butylcalix[4]arene-1,2-crown-3 ligands in cone and 1,2-alternate conformations: synthesis and metal ion extraction.

    Science.gov (United States)

    Zhang, Dongmei; Cao, Xiaodan; Purkiss, David W; Bartsch, Richard A

    2007-04-21

    Novel di-ionizable p-tert-butylcalix[4]arene-1,2-crown-3 ligands in cone and 1,2-alternate conformations were prepared as potential metal ion extractants. Selective bridging of proximal hydroxyl groups of the calix[4]arene platform by a crown-3 polyether unit was achieved under Mitsunobu reaction conditions. In addition to the carboxylic acid group, the acidity tunable N-(X)sulfonyl oxyacetamide functions [OCH(2)C(O)NHSO(2)X] with X group variation from methyl to phenyl to p-nitrophenyl to trifluomethyl were used as the proton-ionizable groups. Conformations and regioselectivities of the new ligands were established by (1)H and (13)C NMR spectroscopy. Competitive solvent extractions of alkali metal cations and of alkaline earth metal cations from aqueous solutions into chloroform were performed, as were single species extractions of lead(ii) and mercury(ii).

  15. Electrical properties of Ba(Dy{sub 1/2}Nb{sub 1/2})O{sub 3} ceramic

    Energy Technology Data Exchange (ETDEWEB)

    Nath, K. Amar, E-mail: karn190@gmail.com [University Department of Physics, T.M. Bhagalpur University, Bhagalpur 812007 (India); Chandra, K. P., E-mail: kpchandra23@gmail.com [Department of Physics, S.M. College, Bhagalpur 812001 (India); Dubey, K., E-mail: kirandubey45@yahoo.com [Department of Physics, G.S. College for Women 831001 (India); Prasad, K., E-mail: k.prasad65@gmail.com [University Department of Physics, T.M. Bhagalpur University, Bhagalpur 812007 (India); Aryabhatta Centre for Nanoscience and Nanotechnology, Aryabhatta Knowledge University, Patna, 800001 (India)

    2016-05-06

    Polycrystalline Ba(Dy{sub 1/2}Nb{sub 1/2})O{sub 3} was prepared using a high-temperature solid-state reaction method. X-ray diffraction analysis indicated the formation of a single-phase cubic structure having space group Pm3m. AC impedance plots as a function of frequency at different temperatures were used to analyse the electrical behaviour of the sample, which indicated the negative temperature coefficient of resistance character. Complex impedance analysis targeted non-Debye type dielectric relaxation. Frequency dependent ac conductivity data obeyed Jonscher’s power law. The apparent activation energy was estimated to be 0.97 eV at 1 kHz.

  16. 1,2-二酮类化合物的合成研究进展%The Synthesis Development of 1,2-Diketone

    Institute of Scientific and Technical Information of China (English)

    庄丹闻; 崔冬梅

    2010-01-01

    1,2-二酮类化合物作为重要的有机合成中间体被广泛应用在高分子材料、农药、医药、化工原料等领域,在医药领域的应用主要是合成一些咪唑环、喹诺西林类的药物.也可以用于合成一些聚合物.本文概述了通过不同的原料,采用氧化、重排、亲核取代的方法得到1,2-二酮类化合物.

  17. Tetraaqua{1-[(1H-1,2,3-benzotriazol-1-ylmethyl]-1H-1,2,4-triazole}sulfatozinc(II dihydrate

    Directory of Open Access Journals (Sweden)

    Yan-Zhi Wang

    2010-11-01

    Full Text Available In the title complex, [Zn(SO4(C9H8N6(H2O4]·2H2O, the ZnII ion is six-coordinated by one N atom from a 1-[(1H-1,2,3-benzotriazol-1-ylmethyl]-1H-1,2,4-triazole ligand and five O atoms from one monodentate sulfate anion and four water molecules in a distorted octahedral geometry. The sulfate tetrahedron is rotationally disordered over two positions in a 0.618 (19:0.382 (19 ratio. In the crystal, adjacent molecules are linked through O—H...O and O—H...N hydrogen bonds involving the cation, the anion, and the coordinated and uncoordinated water molecules into a three-dimensional network.

  18. Tetraaqua{1-[(1H-1,2,3-benzotriazol-1-ylmethyl]-1H-1,2,4-triazole}sulfatocadmium dihydrate

    Directory of Open Access Journals (Sweden)

    Yu-xian Li

    2011-09-01

    Full Text Available In the title complex, [Cd(SO4(C9H8N6(H2O4]·2H2O, the CdII ion is six-coordinated by one N atom from a 1-[(1H-1,2,3-benzotriazol-1-ylmethyl]-1H-1,2,4-triazole ligand and by five O atoms from four water molecules and one monodentate sulfate anion in a distorted octahedral geometry. The sulfate tetrahedron is rotationally disordered over two positions in a 0.651 (12:0.349 (12 ratio. In the crystal, adjacent molecules are linked through O—H...O and O—H...N hydrogen bonds into a three-dimensional network.

  19. Design and synthesis of new imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazine derivatives with antiproliferative activity against melanoma cells.

    Science.gov (United States)

    Garamvölgyi, Rita; Dobos, Judit; Sipos, Anna; Boros, Sándor; Illyés, Eszter; Baska, Ferenc; Kékesi, László; Szabadkai, István; Szántai-Kis, Csaba; Kéri, György; Őrfi, László

    2016-01-27

    Melanoma is an aggressive form of skin cancer and it is generally associated with poor prognosis in patients with late-stage disease. Due to the increasing occurrence of melanoma, there is a need for the development of novel therapies. A new series of diarylamide and diarylurea derivatives containing imidazo[1,2-a]pyridine or imidazo[1,2-a]pyrazine scaffold was designed and synthesized to investigate their in vitro efficacy against the A375P human melanoma cell line. We found several compounds expressing submicromolar IC50 values against the A375P cells, from which 15d, 17e, 18c, 18h, 18i demonstrated the highest potencies with IC50 below 0.06 μM.

  20. Intra-amygdala inhibition of ERK(1/2) potentiates the discriminative stimulus effects of alcohol.

    Science.gov (United States)

    Besheer, Joyce; Fisher, Kristen R; Cannady, Reginald; Grondin, Julie J M; Hodge, Clyde W

    2012-03-17

    Extracellular signal-regulated kinase (ERK(1/2)) has been implicated in modulating drug seeking behavior and is a target of alcohol and other drugs of abuse. Given that the discriminative stimulus (subjective/interoceptive) effects of drugs are determinants of abuse liability and can influence drug seeking behavior, we examined the role of ERK(1/2) in modulating the discriminative stimulus effects of alcohol. Using drug discrimination procedures, rats were trained to discriminate a moderate intragastric (IG) alcohol dose (1g/kg) versus water (IG). Following an alcohol (1g/kg) discrimination session phosphorylated ERK(1/2) (pERK(1/2)) immunoreactivity (IR) was significantly elevated in the amygdala, but not the nucleus accumbens. Therefore, we hypothesized that intra-amygdala inhibition of ERK(1/2) would disrupt expression of the discriminative stimulus effects of alcohol. However, intra-amygdala or accumbens administration of the MEK/ERK(1/2) inhibitor U0126 (1 and 3μg) had no effect on the discriminative stimulus effects of the training dose of alcohol (1g/kg). Contrary to our hypothesis, intra-amygdala infusion of U0126 (3μg) potentiated the discriminative stimulus effects of a low alcohol dose (0.5g/kg) and had no effect following nucleus accumbens infusion. Importantly, site-specific inhibition of pERK(1/2) in each brain region was confirmed. Therefore, the increase in pERK(1/2) IR in the amygdala following systemic alcohol administration may be reflective of the widespread effects of alcohol on the brain (activation/inhibition of brain circuits), whereas the site specific microinjection studies confirmed functional involvement of intra-amygdala ERK(1/2). These findings show that activity of the ERK signaling pathway in the amygdala can influence the discriminative stimulus effects of alcohol.

  1. Homer proteins mediate the interaction between STIM1 and Cav1.2 channels.

    Science.gov (United States)

    Dionisio, Natalia; Smani, Tarik; Woodard, Geoffrey E; Castellano, Antonio; Salido, Gines M; Rosado, Juan A

    2015-05-01

    STIM1 is a ubiquitous Ca2+ sensor of the intracellular, agonist-sensitive, Ca2+ stores that communicates the filling state of the Ca2+ compartments to plasma membrane store-operated Ca2+ (SOC) channels. STIM1 has been presented as a point of convergence between store-operated and voltage-operated Ca2+ influx, both inducing activation of SOC channels while suppressing Cav1.2 channels. Here we report that Homer proteins play a relevant role in the communication between STIM1 and Cav1.2 channels. HEK-293 cells transiently expressing Cav1.2 channel subunits α1, β2 and α2δ-1 exhibited a significant Ca2+ entry upon treatment with a high concentration of KCl. In Cav1.2-expressing cells, treatment with thapsigargin (TG), to induce passive discharge of the intracellular Ca2+ stores, resulted in Ca2+ influx that was significantly greater than in cells not expressing Cav1.2 channels, a difference that was abolished by nifedipine and diltiazem. Treatment with TG induces co-immunoprecipitation of Homer1 with STIM1 and the Cav1.2 α1 subunit. Impairment of Homer function by introduction of the synthetic PPKKFR peptide into cells, which emulates the proline-rich sequences of the PPXXF motif, or using siRNA Homer1, reduced the association of STIM1 and the Cav1.2 α1 subunit. These findings indicate that Homer is important for the association between both proteins. Finally, treatment with siRNA Homer1 or the PPKKFR peptide enhanced the nifedipine-sensitive component of TG response in Cav1.2-expressing cells. Altogether, these findings provide evidence for a new role of Homer1 supporting the regulation of Cav1.2 channels by STIM1. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. Anti-adipogenic effect of epiberberine is mediated by regulation of the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways.

    Science.gov (United States)

    Choi, Jae Sue; Kim, Ji-Hye; Ali, Md Yousof; Jung, Hee Jin; Min, Byung-Sun; Choi, Ran Joo; Kim, Gun-Do; Jung, Hyun Ah

    2015-12-01

    It has been reported that alkaloids derived from Coptis chinensis exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating peroxisome proliferation-activity receptor-γ (PPAR-γ) and CCAAT/enhancer binding protein-α (C/EBP-α). However, the signaling-based mechanism of the inhibitory role of epiberberine in the early stages of 3T3-L1 adipocyte differentiation is uncharacterized. Here, we show that epiberberine had inhibitory effects on adipocyte differentiation and significantly decreased lipid accumulation by downregulating an adipocyte-specific transcription factor, sterol regulatory element-binding protein-1 (SREBP-1). Furthermore, we observed that epiberberine markedly suppressed the differentiation-mediated phosphorylation of components of both the Raf/mitogen-activated protein kinase 1 (MEK1)/extracellular signal-regulated protein kinase 1/2 (ERK1/2) and AMP-activated protein kinase-α1 (AMPKα)/Akt pathways. In addition, gene expression of fatty acid synthase (FAS) was significantly inhibited by treatment with epiberberine during adipogenesis. These results indicate that the anti-adipogenic mechanism of epiberberine is associated with inhibition of phosphorylation of Raf/MEK1/ERK1/2 and AMPKα/Akt, followed by downregulation of the major transcription factors of adipogenesis, such as PPAR-γ, C/EBP-α, and SREBP-1, and FAS. Taken together, this study suggests that the anti-adipogenic effect of epiberberine is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways during 3T3-L1 adipocyte differentiation. Moreover, the anti-adipogenic effects of epiberberine were not accompanied by modulation of β-catenin.

  3. Electronic structure, magnetic and electrical properties of multiferroic PbFe{sub 1/2}Ta{sub 1/2}O{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Bharti, Chandrahas, E-mail: bharti_chandrahas@yahoo.com [Department of Physics, Bose Institute, 93/1 Acharya Prafulla Chandra Road, Kolkata 700009 (India); Dutta, Alo [Department of Physics, Bose Institute, 93/1 Acharya Prafulla Chandra Road, Kolkata 700009 (India); Shannigrahi, Santiranjan [Institute of Materials Research and Engineering (IMRE), 3 Research Link, Singapore 117602 (Singapore); Sinha, T.P. [Department of Physics, Bose Institute, 93/1 Acharya Prafulla Chandra Road, Kolkata 700009 (India)

    2012-03-15

    Structural analysis of the synthesized lead iron tantalate, PbFe{sub 1/2}Ta{sub 1/2}O{sub 3} (PFT) is performed by the refinement of the X-ray diffraction data at room temperature using the GSAS code. Energy dispersive X-ray spectrometry analysis is done to find out the chemical composition. The electronic structure of PFT is calculated by the first principles full potential linearized augmented plane wave method. The spin polarized density of states shows the insulating nature. The magnetic moment of 4.3 {mu}B per Fe ion is obtained from the electronic structure calculation using the GGA+U method and compared with the available experimental data. The electronic structure of the PFT is verified by X-ray photoemission spectroscopy. The dielectric spectroscopy is applied to investigate the electrical properties of PFT in the frequency range from 100 Hz to 1 MHz and in the temperature range from 183 to 253 K. The frequency dependent electrical data are analyzed by conductivity formalism. The relaxation mechanism is explained using the Cole-Cole approach. - Highlights: Black-Right-Pointing-Pointer Rietveld refinement of PbFe{sub 1/2}Ta{sub 1/2}O{sub 3} (PFT) is performed using the GSAS code. Black-Right-Pointing-Pointer The electronic structure of PFT is calculated by the first principles. Black-Right-Pointing-Pointer The spin polarized density of states show the insulating nature of PFT. Black-Right-Pointing-Pointer The magnetic moment of PFT is 4.3 {mu}B per Fe ion.

  4. The sphingolipid long-chain base-Pkh1/2-Ypk1/2 signaling pathway regulates eisosome assembly and turnover.

    Science.gov (United States)

    Luo, Guangzuo; Gruhler, Albrecht; Liu, Ying; Jensen, Ole N; Dickson, Robert C

    2008-04-18

    Eisosomes are recently described fungal structures that play roles in the organization of the plasma membrane and endocytosis. Their major protein components are Pil1 and Lsp1, and previous studies showed that these proteins are phosphorylated by the sphingolipid long-chain base-activated Pkh1 and Pkh2 protein kinases in vitro. We show that Pkh1 and Pkh2 phosphorylate Pil1 and Lsp1 in vivo to produce species B, and that heat stress, which activates Pkh1 and Pkh2, generates a more highly phosphorylated species, C. Cells with low Pkh activity lack species B and C and contain abnormally organized eisosomes. To verify that Pil1 phosphorylation is essential for correct eisosome organization, phosphorylated serine and threonine residues were identified and changed to alanines. A variant Pil1 protein lacking five phosphorylation sites did not form eisosomes during log phase growth, indicating that phosphorylation is critical for eisosome organization. We also found that eisosomes are dynamic structures and disassemble when the Ypk protein kinases, which are activated by the sphingolipid-Pkh signaling pathway, are inactivated or when the sphingolipid signal is pharmacologically blocked with myriocin. We conclude that eisosome formation and turnover are regulated by the sphingolipid-Pkh1/2-Ypk1/2 signaling pathway. These data and previous data showing that endocytosis is regulated by the sphingolipid-Pkh1/2-Ypk1/2 signaling pathway suggest that Pkh1 and -2 respond to changes in membrane sphingolipids and transmit this information to eisosomes via Pil1 phosphorylation. Eisosomes then control endocytosis to align the composition and function of the plasma membrane to match demand.

  5. Mesoionic pyrido[1,2-a]pyrimidinones: Discovery of dicloromezotiaz as a lepidoptera insecticide acting on nicotinic acetylcholine receptors(1,2).

    Science.gov (United States)

    Zhang, Wenming; Holyoke, Caleb W; Barry, James; Cordova, Daniel; Leighty, Robert M; Tong, My-Hanh T; Hughes, Kenneth A; Lahm, George P; Pahutski, Thomas F; Xu, Ming; Briddell, Twyla A; McCann, Stephen F; Henry, Yewande T; Chen, Yuzhong

    2017-02-15

    A novel class of mesoionic pyrido[1,2-a]pyrimidinones has been discovered with exceptional insecticidal activity controlling a number of insect species. In this communication, we report the part of the optimization program that led to the identification of dicloromezotiaz as a potent insecticide to control a broad range of lepidoptera. Our efforts in discovery, synthesis, structure-activity relationship elucidation, and biological activity evaluation are also presented.

  6. Magnetoelectric effect in antiferromagnetic multiferroic Pb (F e1 /2N b1 /2)O3 and its solid solutions with PbTi O3

    Science.gov (United States)

    Laguta, V. V.; Stephanovich, V. A.; Raevski, I. P.; Raevskaya, S. I.; Titov, V. V.; Smotrakov, V. G.; Eremkin, V. V.

    2017-01-01

    Antiferromagnets (AFMs) are presently considered as promising materials for applications in spintronics and random access memories due to the robustness of information stored in the AFM state against perturbing magnetic fields. In this respect, AFM multiferroics may be attractive alternatives for conventional AFMs as the coupling of magnetism with ferroelectricity (magnetoelectric effect) offers an elegant possibility of electric-field control and switching of AFM domains. Here we report the results of comprehensive experimental and theoretical investigations of the quadratic magnetoelectric (ME) effect in single crystals and highly resistive ceramics of Pb (F e1 /2N b1 /2)O3 (PFN) and (1 -x ) Pb (F e1 /2N b1 /2) O3-x PbTi O3(PFN -x PT ) . We are interested primarily in the temperature range of the multiferroic phase, T <150 K , where the ME coupling coefficient is extremely large (as compared to the well-known multiferroic BiFe O3 ) and shows sign reversal at the paramagnetic-to-antiferromagnetic phase transition. Moreover, we observe strong ME response nonlinearity in the AFM phase in the magnetic fields of only a few kOe. To describe the temperature and magnetic field dependencies of the above unusual features of the ME effect in PFN and PFN-x PT , we use a simple phenomenological Landau approach which explains experimental data surprisingly well. Our ME measurements demonstrate that the electric field of only 20-25 kV/cm is able to switch the AFM domains and align them with ferroelectric ones even in PFN ceramic samples.

  7. An indolocarbazole dimer as a new stereodynamic probe for chiral 1,2-diamines.

    Science.gov (United States)

    Jeon, Hae-Geun; Kim, Min Jun; Jeong, Kyu-Sung

    2014-08-01

    An indolocarbazole dimer that contains aldehyde groups at both ends was prepared by connecting two monomeric units through a rod-like 1,4-butadiynyl spacer. Upon mixing with chiral 1,2-diamines at room temperature, the dimer was in situ converted to the corresponding cyclic diimines in the presence of tetrabutylammonium acetate as a template. The resulting diimines fold to helical conformations of right-handed (P) or left-handed (M) orientations, depending on the absolute stereochemistries of chiral 1,2-diamines. The patterns and intensities of the CD spectra can be used to determine the absolute configurations and enantiomeric excesses of chiral 1,2-diamines.

  8. Spasmolytic agents. 2. 1,2,3,4-Tetrahydro-2-naphthylamine derivatives.

    Science.gov (United States)

    Kanao, M; Hashizume, T; Ichikawa, Y; Irie, K; Isoda, S

    1982-11-01

    N-[(Benzoyloxy)alkyl]-1,2,3,4-tetrahydro-2-naphthylamine derivatives were synthesized from 1,2,3,4-tetrahydro-2-naphthylamines and evaluated for their spasmolytic. Some of these compounds showed a nerve-selective effect on colon rather than stomach in anesthetized dogs and were found to be equal to or more active than the reference drug (mebeverine). The biological data have indicated some structure-activity relationships. Among these compounds, N-ethyl-N-[6-(3,4-dimethoxybenzoyl)oxy]hexyl]-1,2,3,4-tetrahydro-6-methoxy-2- napththylamine hydrochloride (63) was found to be the most active spasmolytic agent.

  9. Spectroscopic and Structural Study of the 1:2 Aluminium(Ⅲ) Complex of Quercetin

    Institute of Scientific and Technical Information of China (English)

    Tian Le LIN; Bao Zhen YAN; Gao Fei HU; Mei WANG

    2006-01-01

    Complex formation between aluminium and quercetin(Q) in methanol was investigated by means of 27 Al solid-state, 13C and 1H NMR and MS(ESI), UV and IR spectra. Formation of the 1:2 complex was favored in methanol relative to all other solvent and the predominant species observed of Al(Ⅲ) has a 1:2 stoichiometry. The fine structure of 1:2 aluminum complex of quercetin was that the aluminum central atom chelated with two quercetin molecules and two methoxyl groups between two five membered rings, its coordination is six, the chelated site was 3-hydroxy-4-carbonyl.

  10. Group divisible designs of four groups and block size five with configuration (1; 1; 1; 2

    Directory of Open Access Journals (Sweden)

    Ronald Mwesigwa

    2016-09-01

    Full Text Available We present constructions and results about GDDs with four groups and block size five in which each block has Configuration $(1, 1, 1, 2$, that is, each block has exactly one point from three of the four groups and two points from the fourth group. We provide the necessary conditions of the existence of a GDD$(n, 4, 5; \\lambda_1, \\lambda_2$ with Configuration $(1, 1, 1, 2$, and show that the necessary conditions are sufficient for a GDD$(n, 4, 5; \\lambda_1,$ $\\lambda_2$ with Configuration $(1, 1, 1, 2$ if $n \

  11. Biodegradation of Used Engine Oil by Acinetobacter junii TBC 1.2

    Directory of Open Access Journals (Sweden)

    Witono Basuki

    2015-11-01

    Full Text Available AbstractThe isolates have capability to degrade used engine oil was obtained from soil in the beach contaminatedwith used engine oil. One of the selected isolates TBC 1.2 was identified by its 16s rDNA as Acinetobacterjunii. The microorganism can use hydrocarbons in used engine oil as the sole carbon source and energy, alsoit significantly degraded almost all hydrocarbon compounds in used engine oil. With its ability Acinetobacterjunii TBC 1.2 has a potency to be utilized for bioremediation of soil polluted with used engine oil.Keywords : biodegradation, used engine oil, Acenitobacter junii TBC 1.2

  12. Facile synthesis of 1',2'-cis-beta-pyranosyladenine nucleosides.

    Science.gov (United States)

    Ando, Takayuki; Shinohara, Hisashi; Luo, Xiong; Kandeel, Mahmoud; Kitade, Yukio

    2007-12-10

    1',2'-cis-beta-Glycosyladenine nucleosides, such as beta-altroside, beta-mannoside, and beta-idoside, were efficiently synthesized from the corresponding 1',2'-trans-beta-6-chloropurine derivatives, beta-glucoside, and beta-galactoside. Nucleophilic substitution of the O-trifluoromethanesulfonyl groups at the C-2' and/or 3' was carried out using tetrabutylammonium acetate or cesium acetate under mild conditions. Subsequent deprotection and amidation afforded the desired compounds, 1',2'-cis-beta-pyranosyladenine nucleosides.

  13. Palladium-catalyzed cross coupling reactions of 4-bromo-6H-1,2-oxazines

    Directory of Open Access Journals (Sweden)

    Reinhold Zimmer

    2009-09-01

    Full Text Available A number of 4-aryl- and 4-alkynyl-substituted 6H-1,2-oxazines 8 and 9 have been prepared in good yields via cross coupling reactions of halogenated precursors 2, which in turn are easily accessible by bromination of 6H-1,2-oxazines 1. Lewis-acid promoted reaction of 1,2-oxazine 9c with 1-hexyne provided alkynyl-substituted pyridine derivative 12 thus demonstrating the potential of this approach for the synthesis of pyridines.

  14. Prothrombin fragment 1 + 2 (F1 + 2) in effluent is a useful marker for peritoneal permeability in peritoneal dialysis patients using neutral dialysate.

    Science.gov (United States)

    Sakurada, Tsutomu; Kojima, Shigeki; Oishi, Daisuke; Koitabashi, Kenichiro; Miyamoto, Masahito; Shirai, Sayuri; Shibagaki, Yugo; Yasuda, Takashi; Sato, Takeo; Kimura, Kenjiro

    2011-01-01

    To clarify the influence of neutral dialysate (ND) on peritoneum, we examined changes in peritoneal permeability and in various markers of the coagulation and fibrinolytic system in effluent and the correlations between peritoneal permeability and those markers in peritoneal dialysis (PD) patients using ND. We evaluated 14 patients (8 men, 6 women; mean age: 58.6 +/- 12.0 years) who started PD using ND. The peritoneal equilibration test (PET) was performed to assess dialysate-to-plasma ratio for creatinine (D/P Cr) as peritoneal permeability. Coagulation markers [thrombin-antithrombin complex, fibrin monomer (FM), prothrombin fragment 1+2 (F1 + 2)] and fibrinolytic markers (fibrin degradation products, D-dimer) in effluent were also measured. At 2 years, FM in effluent was significantly lower (p = 0.006). The other markers and the D/P Cr did not change significantly. At the initiation of PD and at 2 years, D/P Cr was significantly correlated with F1 + 2 (r = 0.70 and 0.76 respectively, p permeability in PD patients using ND.

  15. Synthesis optimisation and characterisation of the organic-inorganic layered materials ZnS(m-xylylenediamine)1/2 and ZnS(p-xylylenediamine)1/2

    Science.gov (United States)

    Luberda-Durnaś, K.; Guillén, A. González; Łasocha, W.

    2016-06-01

    Hybrid organic-inorganic layered materials of the type ZnS(amine)1/2, where amine=m-xylylenediamine (MXDA) or p-xylylenediamine (PXDA), were synthesised using a simple solvothermal method. Since the samples crystallised in the form of very fine powder, X-ray powder diffraction techniques were used for structural characterisation. The crystal structure studies, involving direct methods, show that both compounds crystallised in the orthorhombic crystal system, but in different space groups: ZnS(MXDA)1/2 in non-centrosymmetric Ccm21, ZnS(PXDA)1/2 in centrosymmetric Pcab. The obtained materials are built according to similar orders: semiconducting monolayers with the formula ZnS, parallel to the (010) plane, are separated by diamines. The organic and inorganic fragments are connected by covalent bonds between metal atoms of the layers and nitrogen atoms of the amino groups. The optical properties of the hybrid materials differ from those of their bulk counterpart. In both compounds a blue-shift of about 0.8 or 0.9 eV was observed with reference to the bulk phase of ZnS.

  16. Determination of magic wavelengths for the $7s ~ {^2}S_{1/2}-7p ~ {^2}P_{3/2,1/2}$ transitions in Fr atom

    CERN Document Server

    Singh, Sukhjit; Arora, Bindiya

    2016-01-01

    Magic wavelengthsfor the $7S_{1/2}-7P_{1/2,3/2}$ transitions in Fr were reported by Dammalapati \\textit{et al.} in [Phys. Rev. A 93, 043407 (2016)]. These $\\lambda_{\\rm{magic}}$ were determined by plotting dynamic polarizabilities ($\\alpha$) of the involved states with the above transitions against a desired range of wavelength. Electric dipole (E1) matrix elements listed in [J. Phys. Chem. Ref. Data 36, 497 (2007)], from the measured lifetimes of the $7P_{1/2,3/2}$ states and from the calculations considering core-polarization effects in the relativistic Hartree-Fock (HFR) method, were used to determine $\\alpha$. However, contributions from core correlation effects and from the E1 matrix elements of the $7P-7S$, $7P-8S$ and $7P-6D$ transitions to $\\alpha$ of the $7P$ states were ignored. In this work, we demonstrate importance of these contributions and improve accuracies of $\\alpha$ further by replacing the E1 matrix elements taken from the HFR method by the values obtained employing relativistic coupled-cl...

  17. ERF1_2 -- Enhanced River Reach File 2.0

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The digital segmented network based on watershed boundaries, ERF1_2, includes enhancements to the U.S. Environmental Protection Agency's River Reach File 1 (RF1)...

  18. The influence of oxygen on the surface chemistry of 1,2-propanediol on Pd(111)

    Science.gov (United States)

    Williams, Rhea M.; Medlin, J. Will

    2014-01-01

    The surface chemistry of 1,2-propanediol (PDO) has been studied on oxygen precovered Pd(111) using temperature programmed desorption (TPD) and high-resolution electron energy loss spectroscopy (HREELS). Adsorbed 1,2-propanedioxy (-OCH(CH3)CH2O-) forms from the activation of the O-H bonds. When the concentration of O(a) is large compared to 1,2-propanedioxy, no H2 is produced and the dialkoxide reacts to form H2O, CO through decarbonylation, and CO2 through decarboxylation. Unreacted oxygen also desorbs as O2 at high temperature. Conversely, when the concentration of O(a) is small relative to 1,2-propanedioxy, the dialkoxide reacts to form decomposition products (H2, CO), oxidation products (H2O, glyoxal, methylglyoxal, formaldehyde) and deoxygenation products (ethylene, propylene). Co-adsorbed oxygen increases the overall coverage of PDO that can undergo decomposition, which in turn strongly influences decomposition activation barriers and products.

  19. Determination of the hyperfine coupling constant of cesium 7S1/2 state

    CERN Document Server

    Yang, Guang; Yang, Baodong; Wang, Junmin

    2016-01-01

    We report the hyperfine splitting (HFS) measurement of cesium (Cs) 7S1/2 state by optical-optical double-resonance spectroscopy in the 6S1/2-6P3/2-7S1/2 (852 nm + 1470 nm) ladder-type system. The HFS frequency calibration is performed by employing a phase-type waveguide electro-optic modulator together with a stable confocal Fabry-Perot cavity. From the measured HFS between F"= 3 and F"= 4 manifolds of Cs 7S1/2 state [HFS = 2183.273(37) MHz], we have determined the magnetic dipole hyperfine coupling constant [A = 545.818(09) MHz], which is in good agreement with the previous work but much more accurate.

  20. Proving the AGT relation for N_f = 0,1,2 antifundamentals

    CERN Document Server

    Hadasz, Leszek; Suchanek, Paulina

    2010-01-01

    Using recursive relations satisfied by Nekrasov partition functions and by irregular conformal blocks we prove the AGT correspondence in the case of N=2 superconformal SU(2) quiver gauge theories with N_f = 0,1,2 antifundamental hypermultiplets

  1. Enantioselective Synthesis of Terminal 1,2-Diols from Acyl Chlorides

    Institute of Scientific and Technical Information of China (English)

    邵攀霖; 申理滔; 叶松

    2012-01-01

    Optically active terminal 1,2-diols were prepared with high enantiopurity via the TMS-quinidine-catalyzed en- antioselective cyclization of acyl chlorides and oxaziridine, followed by reductive ring-opening of the cycloadducts.

  2. Neel order in the two-dimensional S=1/2 Heisenberg Model

    OpenAIRE

    Löw, Ute

    2007-01-01

    The existence of Neel order in the S=1/2 Heisenberg model on the square lattice at T=0 is shown using inequalities set up by Kennedy, Lieb and Shastry in combination with high precision Quantum Monte Carlo data.

  3. New Salmonella serotype: Salmonella enteritidis serotype Grandhaven (30(1):r:1,2).

    OpenAIRE

    McDougal, D L; Treleaven, B E; Renshaw, E C

    1982-01-01

    A new Salmonella serotype, Salmonella enteritidis serotype Grandhaven (30(1):r:1,2), was isolated from the stool of a 35-year-old man with mild gastroenteritis. He had just returned from Sudan, Africa.

  4. Batch gradient method with smoothing L1/2 regularization for training of feedforward neural networks.

    Science.gov (United States)

    Wu, Wei; Fan, Qinwei; Zurada, Jacek M; Wang, Jian; Yang, Dakun; Liu, Yan

    2014-02-01

    The aim of this paper is to develop a novel method to prune feedforward neural networks by introducing an L1/2 regularization term into the error function. This procedure forces weights to become smaller during the training and can eventually removed after the training. The usual L1/2 regularization term involves absolute values and is not differentiable at the origin, which typically causes oscillation of the gradient of the error function during the training. A key point of this paper is to modify the usual L1/2 regularization term by smoothing it at the origin. This approach offers the following three advantages: First, it removes the oscillation of the gradient value. Secondly, it gives better pruning, namely the final weights to be removed are smaller than those produced through the usual L1/2 regularization. Thirdly, it makes it possible to prove the convergence of the training. Supporting numerical examples are also provided.

  5. USGS 1:12000 (Quarter 7 1/2 Minute) Quadrangle Index

    Data.gov (United States)

    Minnesota Department of Natural Resources — This is a mathematically generated grid in which each polygon represents one quarter of a standard USGS 7 1/2 minute quadrangle. The result is a 3 3/4 minute...

  6. Surficial geology of the Cabot 7 1/2 minute quadrangle, Vermont

    Data.gov (United States)

    Vermont Center for Geographic Information — Digital data from VG2016-3 Springston, G., 2016, Surficial geology of the Cabot 7 1/2 minute quadrangle, Vermont: Vermont Geological Survey Open File Report...

  7. Microwave Spectrum and Molecular Structure of the ARGON-CIS-1,2-DICHLOROETHYLENE Complex

    Science.gov (United States)

    Marshall, Mark D.; Leung, Helen O.; Nelson, Craig J.; Yoon, Leonard H.

    2016-06-01

    The non-planar molecular structure of the complex formed between the argon atom and cis-1,2-dichloroethylene is determined via analysis of its microwave spectrum. Spectra of the 35Cl and 37Cl isotopologues are observed in natural abundance and the nuclear quadrupole splitting due to the two chlorine nuclei is fully resolved. In addition, the complete quadrupole coupling tensor for the cis-1,2-dichloroethylene molecule, including the single non-zero off-diagonal element, has been determined. Unlike the argon-cis-1,2-difluoroethylene and the argon-vinyl chloride complexes, tunneling between the two equivalent non-planar configurations of argon-cis-1,2-dichloroethylene is not observed.

  8. One-pot Synthesis of 4-Trifluoromethyl-1,2-dihydropyrimidines

    Institute of Scientific and Technical Information of China (English)

    LIN,Yun; LIU,Jin-Tao; YANG,Xian-Ji

    2007-01-01

    4-Trifluoromethyl-1,2-dihydropyrimidines were synthesized in moderate yields by the one-pot reaction of 4-ethoxy-1,1,1-trifluoro-3-buten-2-one, aldehydes and ammonia catalyzed by zinc chloride under mild conditions.

  9. Synthesis of 2-Arylimidazo[1,2-a]pyrimidines in Ionic Liquids

    Institute of Scientific and Technical Information of China (English)

    Dan Qian XU; Bao You LIU; Zhen Yuan XU

    2003-01-01

    Room temperature ionic liquids were used as a "green" recyclable alternative toconventional solvents in the synthesis of pharmaceutically useful compounds 2-arylimidazo[1, 2-a]pyrimidines through Tschotschibabin reaction of α-bromoacetophenones with 2-aminopyfinidinein good yields.

  10. Fused 1,2,3-Dithiazoles: Convenient Synthesis, Structural Characterization, and Electrochemical Properties

    Directory of Open Access Journals (Sweden)

    Lidia S. Konstantinova

    2016-05-01

    Full Text Available A new general protocol for synthesis of fused 1,2,3-dithiazoles by the reaction of cyclic oximes with S2Cl2 and pyridine in acetonitrile has been developed. The target 1,2,3-dithiazoles fused with various carbocycles, such as indene, naphthalenone, cyclohexadienone, cyclopentadiene, and benzoannulene, were selectively obtained in low to high yields. In most cases, the hetero ring-closure was accompanied by chlorination of the carbocyclic moieties. With naphthalenone derivatives, a novel dithiazole rearrangement (15→13 featuring unexpected movement of the dithiazole ring from α- to β-position, with respect to keto group, was discovered. Molecular structure of 4-chloro-5H-naphtho[1,2-d][1,2,3]dithiazol-5-one 13 was confirmed by single-crystal X-ray diffraction. Electrochemical properties of 13 were studied by cyclic voltammetry and a complex behavior was observed, most likely including hydrodechlorination at a low potential.

  11. SYNTHESIS OF 1,2-ACEANTHRYLENEDIONE THROUGH ACYLATION OF ANTHRACENE WITH OXALYL CHLORIDE

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Acylation of anthracene and oxalyl chloride in the presence of anhydrous AlCl3 was investigated. Pure 1,2-aceanthrylenedione, which is used as new functional macromolecule, was prepared by extraction and recrystallation. The structure of 1,2-aceanthrylenedione was identified by measure of melting point, GC/MS, FTIR and 1HNMR analyses. The influences of various parameters, such as solvent, dosage of catalyst, molar ratio of anthracene to oxalyl chloride, reaction temperature, and reaction time were studied. The anhydrous AlCl3 was found to catalyze the reaction with high yeild and good selectivity. When the reaction temperature is 303K, reaction time is 5h and molar ratio of anthracene to oxalyl chloride is 1:2, the yield and selectivity of 1,2-aceanthrylenedione is 83.8 % and 92.3% respectively.

  12. SYNTHESIS OF 1,2-ACEANTHRYLENEDIONE THROUGH ACYLATION OF ANTHRACENE WITH OXALYL CHLORIDE

    Institute of Scientific and Technical Information of China (English)

    ZHANG Chunyan; CHEN Min; YU Long; JIANG Deli YAN Yongsheng

    2007-01-01

    Acylation of anthracene and oxalyl chloride in the presence of anhydrous AlCl3 was investigated. Pure 1,2-aceanthrylenedione, which is used as new functional macromolecule, was prepared by extraction and recrystallation. The structure of 1,2-aceanthrylenedione was identified by measure of melting point, GC/MS, FTIR and 1HNMR analyses. The influences of various parameters,such as solvent, dosage of catalyst, molar ratio of anthracene to oxalyl chloride, reaction temperature, and reaction time were studied. The anhydrous AlCl3 was found to catalyze the reaction with high yeild and good selectivity. When the reaction temperature is 303K, reaction time is 5h and molar ratio of anthracene to oxalyl chloride is 1:2, the yield and selectivity of 1,2-aceanthrylenedione is 83.8 % and 92.3% respectively.

  13. Synthesis and Antimicrobial Activity of Some [1,2,4]-Triazole Derivatives

    Directory of Open Access Journals (Sweden)

    Bhimagouda S. Patil

    2013-01-01

    Full Text Available A series of novel [1,2,4]-triazolo piperidine (8, [1,2,4]-triazolo piperazine (9a-c, [1,2,4]-triazolo phenylether (10a-e, and [1,2,4]-triazolo aniline (11a-c derivatives have been synthesized. The chemical structures of the newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, and LCMS. The newly synthesized compounds were screened for antimicrobial activity. Among all the compounds tested, 11b (R4=4-MeO– showed the highest activity against Staphylococcus aureus and Escherichia coli, and 9a (R1 and R2=Cl showed the highest activity against Pseudomonas aeruginosa.

  14. Depolarization temperature and piezoelectric properties of Na1/2Bi1/2TiO3–Na1/2Bi1/2(Zn1/3Nb2/3)O3 ceramics by two-stage calcination method

    Indian Academy of Sciences (India)

    Xin-Yu Liu; Chang-Rong Zhou; Zhao-Hui Shan

    2007-12-01

    A new group of NBT-based lead-free piezoelectric ceramics, Na1/2Bi1/2TiO3–Na1/2Bi1/2(Zn1/3Nb2/3)O3, was synthesized using the two-stage calcination method and depolarization temperatures and piezoelectric properties were also investigated. The XRD analysis showed that the ceramics system had a morphotropic phase boundary (MPB) between the rhombohedral and the tetragonal structure. The highest piezoelectric properties of 33 = 97 pC/N and = 0.46 were obtained near MPB compositions. Furthermore, the depolarization temperatures near MPB compositions were slightly decreased and the lowest d was maintained at 210°C.

  15. Microwave spectroscopic observation of a Wigner solid within the ν =1 /2 fractional quantum Hall effect

    Science.gov (United States)

    Hatke, A. T.; Liu, Yang; Engel, L. W.; Pfeiffer, L. N.; West, K. W.; Baldwin, K. W.; Shayegan, M.

    2017-01-01

    We have studied the microwave spectra of a wide quantum well for Landau level fillings, ν , just below 1/2, under conditions where the ν =1 /2 fractional quantum Hall effect (FQHE) is present. One resonance in the spectra exhibits intensity variations with ν in striking agreement with that expected for a pinning mode of a Wigner solid of quasiholes of this FQHE state. This resonance is also quite sensitive to asymmetrization of the growth-direction charge distribution in the quantum well by gate bias. Another resonance in the spectra is associated with a different bilayer Wigner solid that also exists at much lower ν than the 1/2 FQHE, and that appears to coexist with the 1/2 quasihole solid.

  16. The Nature of Acid-Catalyzed Acetalization Reaction of 1,2-Propylene Glycol and Acetaldehyde

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Chen; Chen, Hui; Li, Xia; Hu, Jianli; Liang, Baochen [Tianjin University of Technology, Tianjin (China)

    2015-08-15

    We investigated catalytic activity of ion-exchange resins in acetalization of 1,2-propylene glycol with acetaldehyde. The impacts of reaction variables, such as temperature, reaction time, catalyst loading and feedstock composition, on the conversion of 1,2-propylene glycol were measured. The life of the catalyst was also studied. Furthermore, the reaction kinetics of 1,2-propylene glycol acetalization was studied. It was found that reaction rate followed the first order kinetics to acetaldehyde and 1,2-propylene glycol, respectively. Therefore, overall acetalization reaction should follow the second-order reaction kinetics, expressed as r - kC{sup nA}{sub A}C{sup nB}{sub B} = 19.74e{sup -650/T}C{sup 1}{sub A}C{sup 1}{sub B}.

  17. The anomalous dimension of spin-1/2 baryons in many flavors QCD

    CERN Document Server

    Vecchi, Luca

    2016-01-01

    We derive the anomalous dimension of spin-1/2 baryon operators in QCD at leading 1/Nf order. Within this approximation the complication resulting from the mixing with an infinite number of evanescent operators can be easily bypassed.

  18. USGS 1:24000 (7 1/2 Minute) Quadrangle Index

    Data.gov (United States)

    Minnesota Department of Natural Resources — Mathematically generated grid representing USGS 7 1/2 Minute Quadrangle Map outlines. Quadrangle names and standard identifiers are included with the data set.

  19. Antimicrobial activity of 2,4-dihydro-[1,2,4]triazol-3-one derivatives.

    Science.gov (United States)

    Stefańska, Joanna; Struga, Marta; Tyski, Stefan; Kossakowski, Jerzy; Dobosz, Maria

    2008-01-01

    Antibacterial and antifungal activity of 2,4-dihydro- [1,2,4]triazol-3-one derivatives were examined by the disc-diffusion method (growth inhibition zone diameter in agar medium). The MIC's for the most active agents were determined. Of all the tested compounds, aminomethyl derivatives of 2,4-dihydro-[1,2,4]triazol-3-one exhibit activity against the majority of microorganisms studied.

  20. Deliverable 1.2.7: Cross-cultural benefit segmentation of consumers

    OpenAIRE

    Reinders, M.J.; Onwezen, M.C.; Sijtsema, S.J.; Zimmermann, K.L.; Berg, van den, Aad; Jasiulewicz, A.; Guardia, M.D.; Guerrero, L.

    2010-01-01

    The present report, deliverable D.1.2.7, gives a final view of the work done in ISAFruit Work Package (WP) 1.2. Average Europe fruit consumption is below the recommended level and moreover the consumption level is still decreasing in Europe. A large survey was carried out in four European countries that consisted of questions regarding the importance consumers attach to food related benefits in general and for specific situations, personal orientations of the consumers, personal characteristi...

  1. Magnetic phenomena at and near nu = 1 / 2 and 1 / 4: theory, experiment, and interpretation

    Science.gov (United States)

    Shankar

    2000-04-24

    I show that the Hamiltonian theory of composite fermions is capable of yielding a unified description in fair agreement with recent experiments on polarization P and relaxation rate 1/T1 in quantum Hall states at filling nu = p/(2ps+1), at and near nu = 1 / 2 and 1 / 4 ( s = 1,2) at zero and nonzero temperatures. I show how rotational invariance and two dimensionality can make the underlying interacting theory behave like a free one in a limited context.

  2. Absorption spectrum, mass spectrometric properties, and electronic structure of 1,2-benzoquinone.

    Science.gov (United States)

    Albarran, Guadalupe; Boggess, William; Rassolov, Vitaly; Schuler, Robert H

    2010-07-22

    Absorption spectrophotometric and mass spectrometric properties of 1,2-benzoquinone, prepared in aqueous solution by the hexachloroiridate(IV) oxidation of catechol and isolated by HPLC, are reported. Its absorption spectrum has a broad moderately intense band in the near UV with an extinction coefficient of 1370 M(-1)cm(-1) at its 389 nm maximum. The oscillator strength of this band contrasts with those of the order-of-magnitude stronger approximately 250 nm bands of most 1,4-benzoquinones. Gaussian analysis of its absorption spectrum indicates that it also has modestly intense higher energy bands in the 250-320 nm region. In atmospheric pressure mass spectrometric studies 1,2-benzoquinone exhibits very strong positive and negative mass 109 signals that result from the addition of protons and hydride ions in APCI and ESI ion sources. It is suggested that the hydride adduct is formed as the result of the highly polar character of ortho-quinone. On energetic collision the hydride adduct loses an H atom to produce the 1,2-benzosemiquinone radical anion. The present studies also show that atmospheric pressure mass spectral patterns observed for catechol are dominated by signals of 1,2-benzoquinone resulting from oxidation of catechol in the ion sources. Computational studies of the electronic structures of 1,2-benzoquinone, its proton and hydride ion adducts, and 1,2-benzosemiquinone radical anion are reported. These computational studies show that the structures of the proton and hydride adducts are similar and indicate that the hydride adduct is the proton adduct of a doubly negatively charged 1,2-benzoquinone. The contrast between the properties of 1,2- and 1,4-benzoquinone provides the basis for considerations on the effects of conjugation in aromatic systems.

  3. Synthesis and Some Reactions of 3-Chloro-2-(cyanomethylene-1,2-dihydroquinoxalines

    Directory of Open Access Journals (Sweden)

    Wolfgang Pfleiderer

    2004-03-01

    Full Text Available 2,3-Dichloroquinoxaline and some of its derivatives have been reacted with malononitrile and ethyl cyanoacetate to yield a variety of 3-chloro-2-(cyanomethylene- 1,2-dihydroquinoxaline derivatives. The reaction of 3-chloro-2-(dicyanomethylene-1,2- dihydroquinoxaline (2e with pyridine and its methyl derivatives led to the zwitterionic structures 6a-6c. The structures of the newly synthesized compounds were assigned by spectroscopic data and elemental analyses.

  4. Platinum Catalyzed Ring-Opening of 1,2-Cyclopropanated Sugars with O-Nucleophiles

    DEFF Research Database (Denmark)

    Beyer, Jürgen; Skaanderup, Philip Robert; Madsen, Robert

    1999-01-01

    In the presence of a catalytic amount of Zeise's dimer 1,2-cyclopropanated sugars undergo regioselective ring-opening at C-1 with O-nucleophiles including alcohols, phenols and water to produce 2-C-branched carbohydrates.......In the presence of a catalytic amount of Zeise's dimer 1,2-cyclopropanated sugars undergo regioselective ring-opening at C-1 with O-nucleophiles including alcohols, phenols and water to produce 2-C-branched carbohydrates....

  5. Purification and biochemica characterisation of endoplasmic reticulum α 1,2-mannosidase from Sporothrix schenckiil

    Directory of Open Access Journals (Sweden)

    Héctor M Mora-Montes

    2010-02-01

    Full Text Available Alpha 1,2-mannosidases from glycosyl hydrolase family 47 participate in N-glycan biosynthesis. In filamentous fungi and mammalian cells, α1,2-mannosidases are present in the endoplasmic reticulum (ER and Golgi complex and are required to generate complex N-glycans. However, lower eukaryotes such Saccharomyces cerevisiae contain only one α1,2-mannosidase in the lumen of the ER and synthesise high-mannose N-glycans. Little is known about the N-glycan structure and the enzyme machinery involved in the synthesis of these oligosaccharides in the dimorphic fungus Sporothrix schenckii. Here, a membrane-bound α-mannosidase from S. schenckii was solubilised using a high-temperature procedure and purified by conventional methods of protein isolation. Analytical zymograms revealed a polypeptide of 75 kDa to be responsible for enzyme activity and this purified protein was recognised by anti-α1,2-mannosidase antibodies. The enzyme hydrolysed Man9GlcNAc2 into Man8GlcNAc2 isomer B and was inhibited preferentially by 1-deoxymannojirimycin. This α1,2-mannosidase was localised in the ER, with the catalytic domain within the lumen of this compartment. These properties are consistent with an ER-localised α1,2-mannosidase of glycosyl hydrolase family 47. Our results also suggested that in contrast to other filamentous fungi, S. schenckii lacks Golgi α1,2-mannosidases and therefore, the processing of N-glycans by α1,2-mannosidases is similar to that present in lower eukaryotes.

  6. Enhancing Natural Attenuation through Bioaugmentation with Aerobic Bacteria that Degrade cis-1,2-Dichloroethene

    Science.gov (United States)

    2010-05-01

    cDCE cis-1,2-dichloroethene cfu colony forming units CMO cyclohexanone monooxygenase DCA 1,2-dichloroethane DNA deoxyribonucleic acid...of JS666) and (2) cyclohexanone monooxygenase (CMO) (based on the cyclohexanone monooxygenase gene of JS666). Additionally, a putative universal (UNI...molecular probes (one based on the isocitrate lyase gene and one based on the cyclohexanone monooygenase gene). In addition, JS666 activity and

  7. Dielectric, piezoelectric, and ferroelectric properties of MnCO3-added 74(Bi(1/2)Na(1/2)) TiO3-20.8(Bi(1/2)K(1/2))TiO3-5.2BaTiO3 lead-free piezoelectric ceramics.

    Science.gov (United States)

    Hu, Hanchen; Zhu, Mankang; Hou, Yudong; Yan, Hui

    2009-05-01

    74(Bi(1/2)Na(1/2))TiO3-20.8(Bi(1/2)K(1/2))TiO3-5.2BaTiO3-x MnCO3 lead-free piezoelectric ceramics were synthesized by conventional solid oxide routine. The tetragonal 74(Bi(1/2)Na(1/2))TiO3-20.8(Bi(1/2)K(1/2))TiO3-5.2 BaTiO3 (BNKB) exhibits high depolarization temperature T(d) of 195 degrees C; however, its properties are far from satisfactory for practical application and need to be improved. The experiments show that the addition of MnCO3 reduces the tetragonality c/a and increases the cell volume. In addition, it revealed that the suitable addition of MnCO3 promotes the sintering and increases the densities of BNKB ceramics. The addition of MnCO3 also enhances the relaxor behavior of BNKB ceramics due to the reconstruct of the disorder arrays. Due to the effect of the crystal lattice, grain growth, and relaxor behavior, the optimal electric properties were realized at MnCO3 addition x of 0.16: the dielectric permittivity epsilon(r) = 1047, dielectric dissipation tandelta = 0.022, piezoelectric strain d33 = 140 pC/N, mechanical coupling k(p) = 0.18, mechanical quality Q(m) = 89 while the depolarization temperature T(d) stays relatively high at 175 degrees C. The effect and mechanism of Mn doping on the electrical properties were discussed in detail.

  8. Remarks on mass and angular momenta for $U(1)^2$-invariant initial data

    CERN Document Server

    Alaee, Aghil

    2015-01-01

    We extend Brill's positive mass theorem to a large class of asymptotically flat, maximal, $U(1)^2$-invariant initial data sets on simply connected four dimensional manifolds $\\Sigma$. Moreover, we extend the local mass angular momenta inequality result Ref [1] for $U(1)^2$ invariant black holes to the case with nonzero stress energy tensor with positive matter density and energy-momentum current invariant under the above symmetries.

  9. su(1,2) Algebraic Structure of XYZ Antiferromagnetic Model in Linear Spin-Wave Frame

    Institute of Scientific and Technical Information of China (English)

    GUAN Yong; JIN Shuo; LIN Bing-Sheng; XIE Bing-Hao; JING Si-Cong; YU Zhao-Xian; HOU Jing-Min

    2008-01-01

    The XYZ antiferromagnetic model in linear spin-wave frame is shown explicitly to have an su(1,2) aigebraic structure: the Hamiltonian can be written as a linear function of the su(1,2) algebra generators. Based on it, the energy eigenvalues are obtained by making use of the similar transformations, and the algebraic diagonalization method is investigated. Some numerical solutions are given, and the results indicate that only one group solution could be accepted in physics.

  10. The Pseudorabies Virus VP1/2 Tegument Protein Is Required for Intracellular Capsid Transport†

    OpenAIRE

    Luxton, G.W. Gant; Lee, Joy I-Hsuan; Haverlock-Moyns, Sarah; Schober, Joseph Martin; Smith, Gregory Allan

    2006-01-01

    Transport of capsids in cells is critical to alphaherpesvirus infection and pathogenesis; however, viral factors required for transport have yet to be identified. Here we provide a detailed examination of capsid dynamics during the egress phase of infection in Vero cells infected with pseudorabies virus. We demonstrate that the VP1/2 tegument protein is required for processive microtubule-based transport of capsids in the cytoplasm. A second tegument protein that binds to VP1/2, UL37, was nec...

  11. WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway.

    Science.gov (United States)

    Zhou, Bo; Wang, Dexuan; Feng, Xiuyan; Zhang, Yiqian; Wang, Yanhui; Zhuang, Jieqiu; Zhang, Xuemei; Chen, Guangping; Delpire, Eric; Gu, Dingying; Cai, Hui

    2012-03-01

    WNK [with no lysine (K)] kinase is a subfamily of serine/threonine kinases. Mutations in two members of this family (WNK1 and WNK4) cause pseudohypoaldosteronism type II featuring hypertension, hyperkalemia, and metabolic acidosis. WNK1 and WNK4 were shown to regulate sodium chloride cotransporter (NCC) activity through phosphorylating SPAK and OSR1. Previous studies including ours have also shown that WNK4 inhibits NCC function and its protein expression. A recent study reported that a phorbol ester inhibits NCC function via activation of extracellular signal-regulated kinase (ERK) 1/2 kinase. In the current study, we investigated whether WNK4 affects NCC via the MAPK ERK1/2 signaling pathway. We found that WNK4 increased ERK1/2 phosphorylation in a dose-dependent manner in mouse distal convoluted tubule (mDCT) cells, whereas WNK4 mutants with the PHA II mutations (E562K and R1185C) lost the ability to increase the ERK1/2 phosphorylation. Hypertonicity significantly increased ERK1/2 phosphorylation in mDCT cells. Knock-down of WNK4 expression by siRNA resulted in a decrease of ERK1/2 phosphorylation. We further showed that WNK4 knock-down significantly increases the cell surface and total NCC protein expressions and ERK1/2 knock-down also significantly increases cell surface and total NCC expression. These data suggest that WNK4 inhibits NCC through activating the MAPK ERK1/2 signaling pathway.

  12. 9,10-Dioxa-1,2-diaza-anthracene derivatives from tetrafluoropyridazine

    Directory of Open Access Journals (Sweden)

    Graham Pattison

    2010-05-01

    Full Text Available Reaction of tetrafluoropyridazine with catechol gives a tricyclic 9,10-dioxa-1,2-diaza-anthracene system by a sequential nucleophilic aromatic substitution ring annelation process, further extending the use of perfluoroheteroaromatic derivatives for the synthesis of unusual polyfunctional heterocyclic architectures. The tricyclic scaffold reacts with amines and sodium ethoxide providing a short series of functional 9,10-dioxa-1,2-diaza-anthracene systems.

  13. NQR Study of the Structural Phase Transition in 1,2-Diphenylhydrazine

    Science.gov (United States)

    Matsuura, Hazime; Matsuzaki, Tomio; Fukazawa, Yuji; Abe, Yoshihito

    1982-12-01

    14N NQR lines in 1,2-diphenylhydrazine have been investigated between 4.2 K and 370 K by using a pulsed spectrometer. With increasing temperature, the number of resonance line in NQR spectra decreased from six lines to three lines above 115 K. The temperature dependence of resonance lines reveals that 1,2-diphenylhydrazine makes a second order structural phase transition around 115 K. An information about the molecular structure is also obtained.

  14. Understanding the Role of TSC1/2 in Cerebellar Purkinje Neurons

    Science.gov (United States)

    2016-09-01

    AWARD NUMBER: W81XWH-15-1-0189 TITLE: Understanding the role of TSC1/2 in cerebellar Purkinje neurons PRINCIPAL INVESTIGATOR: Mustafa Sahin...5a. CONTRACT NUMBER Understanding the role of TSC1/2 in cerebellar Purkinje neurons 5b. GRANT NUMBER W81XWH-15-1-0189 5c. PROGRAM ELEMENT...Purkinje cells are the sole output neuron of the cerebellum, and previously we have shown that Tsc1 mutant Purkinje cells cause autistic-like

  15. Microbial formation, biotechnological production and applications of 1,2-propanediol

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, G.N. [Dept. of Biochemistry and Cell Biology, Rice Univ., Houston, TX (United States); San, K.Y. [Dept. of Bioengineering, Rice Univ., TX (United States)

    2001-07-01

    This short review covers metabolic pathways, genetics and metabolic engineering of 1,2-propanediol formation in microbes. 1,2-Propanediol production by bacteria and yeasts has been known for many years and two general pathways are recognized. One involves the metabolism of deoxyhexoses, where lactaldehyde is formed during the glycolytic reactions and is then reduced to 1,2-propanediol. The second pathway derives from the formation of methylglyoxal from dihydroxyacetonephosphate and its subsequent reduction to 1,2-propanediol. The enzymes involved in the reduction of methylglyoxal can generate isomers of lactaldehyde or acetol, which can be further reduced by specific reductases, giving chiral 1,2-propanediol as the product. The stereospecificity of the enzymes catalyzing the two reduction steps is important in deriving a complete pathway. Through genetic engineering, appropriate combinations of enzymes have been brought together in Escherichia coli and yeast to generate 1,2-propanediol from glucose. The optimization of these strains may yield microbial processes for the production of this widely used chemical. (orig.)

  16. ERα and ERK1/2 MAP kinase expression in microdissected stromal and epithelial endometrial cells

    Directory of Open Access Journals (Sweden)

    Said Abu Alkhair Mohamed

    2014-03-01

    Total and phosphorylated levels for ERK1/2 and ERα were measured by quantitation of signals from Western blots using specific antibodies against the active and total forms of ERK1/2 and against ERα. When the level of the proteins was quantitated and normalized to β actin from microdissected stroma and epithelium, no significant difference was detected in the levels of these proteins between the two tissue compartments. There was a trend toward higher expression in the stroma vs. epithelium, respectively (active ERK1/2 0.45 ± 0.17 vs. 0.2 ± 0.65; total ERK1/2 0.54 ± 0.35 vs. 0.28 ± 0.23; ERα 0.82 ± 0.28 vs. 0.54 ± 0.18; n = 6. These data demonstrate that there are comparable levels of ERα (P = 0.41, total ERK1/2 (P = 0.18 and active ERK1/2 (P = 0.13 in the stroma and epithelium of proliferative phase endometrium with a trend toward higher expression of these proteins in the stromal compartment.

  17. Ovarian Cancer and BRCA1/2 Testing: Opportunities to improve clinical care and disease prevention

    Directory of Open Access Journals (Sweden)

    Katherine eKarakasis

    2016-05-01

    Full Text Available Without prevention or screening options available, ovarian cancer is the most lethal malignancy of the female reproductive tract. High grade serous ovarian cancer (HGSOC is the most common histologic subtype, and the role of germline BRCA1/2 mutation in predisposition and prognosis is established. Given the targeted treatment opportunities with PARP inhibitors, a predictive role for BRCA1/2 mutation has emerged. Despite recommendations to provide BRCA1/2 testing to all women with histologically confirmed HGSOC, uniform implementation remains challenging. The opportunity to review and revise genetic screening and testing practices will identify opportunities where universal adoption of BRCA1/2 mutation testing will impact and improve treatment of women with ovarian cancer. Improving education and awareness of genetic testing for women with cancer, as well as the broader general community, will help focus much needed attention on opportunities to advance prevention and screening programs in ovarian cancer. This is imperative not only for women with cancer, those at risk of developing cancer, but also for their first-degree relatives. In addition, BRCA1/2 testing may have direct implications for patients with other types of cancers, many which are now being found to have BRCA1/2 involvement.

  18. Kinetics of heavy metal inhibition of 1,2-dichloroethane biodegradation in co-contaminated water.

    Science.gov (United States)

    Arjoon, Ashmita; Olaniran, Ademola Olufolahan; Pillay, Balakrishna

    2015-03-01

    Sites co-contaminated with heavy metals and 1,2-DCA may pose a greater challenge for bioremediation, as the heavy metals could inhibit the activities of microbes involved in biodegradation. Therefore, this study was undertaken to quantitatively assess the effects of heavy metals (arsenic, cadmium, mercury, and lead) on 1,2-DCA biodegradation in co-contaminated water. The minimum inhibitory concentrations (MICs) and concentrations of the heavy metals that caused half-life doubling (HLDs) of 1,2-DCA as well as the degradation rate coefficient (k(1)) and half-life (t(½)) of 1,2-DCA were measured and used to predict the toxicity of the heavy metals in the water microcosms. An increase in heavy metal concentration resulted in a progressive increase in the t(½) and relative t(½) and a decrease in k(1). The MICs and HLDs of the heavy metals were found to vary, depending on the heavy metals type. In addition, the presence of heavy metals was shown to inhibit 1,2-DCA biodegradation in a dose-dependent manner, with the following order of decreasing inhibitory effect: Hg(2+)  > As(3+)  > Cd(2+)  > Pb(2+). Findings from this study have significant implications for the development of bioremediation strategies for effective degradation of 1,2-DCA and other related compounds in wastewater co-contaminated with heavy metals.

  19. Fluorescent property of 3-hydroxymethyl imidazo[1,2-a]pyridine and pyrimidine derivatives

    Directory of Open Access Journals (Sweden)

    Velázquez-Olvera Stephania

    2012-08-01

    Full Text Available Abstract Background Imidazo[1,2-a]pyridines and pyrimidines are important organic fluorophores which have been investigated as biomarkers and photochemical sensors. The effect on the luminescent property by substituents in the heterocycle and phenyl rings, have been studied as well. In this investigation, series of 3-hydroxymethyl imidazo[1,2-a]pyridines and pyrimidines were synthesized and evaluated in relation to fluorescence emission, based upon the hypothesis that the hydroxymethyl group may act as an enhancer of fluorescence intensity. Results Compounds of both series emitted light in organic solvents dilutions as well as in acidic and alkaline media. Quantitative fluorescence spectroscopy determined that both fused heterocycles fluoresced more intensely than the parent unsubstituted imidazo[1,2-a]azine fluorophore. In particular, 3-hydroxymethyl imidazo[1,2-a]pyridines fluoresced more intensely than 3-hydroxymethyl imidazo[1,2-a]pyrimidines, the latter emitting blue light at longer wavelengths, whereas the former emitted purple light. Conclusion It was concluded that in most cases the hydroxymethyl moiety did act as an enhancer of the fluorescence intensity, however, a comparison made with the fluorescence emitted by 2-aryl imidazo[1,2-a]azines revealed that in some cases the hydroxymethyl substituent decreased the fluorescence intensity.

  20. Mechanism of 1,2-shift through p -complex transition state

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A systematic calculation of the potential curves or surfaces for 1,2-shift has been realized by using MNDO or other models in MOPAC programs. By referring to the previous authors' viewpoints, the 1,2-shift can be divided into two categories. 1,2-electron-deficient shift is that the electronic configuration of the atom which accepts the migrating group is a cation or an electron- deficient atom, and 1,2-anion shift is the one that the accepted atom of the migration group is a negative ion. In terms of the experimental facts and the calculation of the potential surfaces, in electron-deficient shift such as Beckmann or Baeyer-Villiger rearrangement, the migration occurs through a transition complex formed between the p -bond and the cation or electron-deficient migrating group, but in anion shift such as Wittig or Stevens rearrangement, the electron pair in p -orbit excites at first to p * orbit, and then the migration occurs through the new formed complex between the anion migration group and the vacant p orbit. The above mechanisms explain reasonably the intramolecular properties, the configuration retentions of the migration group, and the corresponding migratory aptitudes of the two type 1,2-shifts. The partial and less important free radical reaction of 1,2-anion shift has been explained by the p -complex mechanism too.

  1. New 1,2,4-triazine bearing compounds: molecular modeling, synthesis and biotesting

    Directory of Open Access Journals (Sweden)

    Negrutska V. V.

    2009-12-01

    Full Text Available Aim. To enlarge a spectrum of biologically active compounds in the series of the 1,2,4-triazino[5,6-b] [1,4]benzothiazine (1,2,4-TBT derivatives and reveal among them efficient inhibitors of RNA synthesis Methods. The methods of structure optimization of the 3-oxo-1,2,4-TBT by fragment-oriented substitution, the molecular doking of new structures in a virtual target, the rational chemical synthesis of the theoretically predicted compounds and their testing in the system of transcription in vitro. Results. The series of 1,2,4-TBT derivatives with substituents in the benzene and triazine cycles of a base molecule were synthesized. The testing of synthesized compounds in the in vitro transcription system directed by T7 RNA polymerase revealed the structure- and concentration-dependent inhibition of the RNA synthesis by some of these compounds. The experimental and virtual screening data for all investigated compounds have a good correlation. It was found that most effective derivative is the 3-oxo-8-butyl-1,2,4-TBT which completely inhibited transcription at the concentration of 6 mg/ml. Conclusions. The biotesting results allow us to assume that the inhibition of RNA synthesis is caused by binding of the 3-oxo- 8-butyl-1,2,4-TBT to both free RNA polymerase molecules and those including in a transcriptional complex with DNA

  2. Holmium-doped ZBLAN fiber lasers at 1.2 μm

    Science.gov (United States)

    Zhu, X.; Zong, J.; Norwood, R. A.; Chavez-Person, A.; Peyghambarian, N.; Prasad, N.

    2012-02-01

    Holmium (Ho3+)-doped ZBLAN glasses have been investigated for the purpose of achieving efficient fiber lasers at 1.2 μm. Because of the long lifetime of the upper laser level and the small phonon energy in Ho3+-doped ZBLAN glasses, strong fluorescence at 1.2 μm that usually cannot be observed in Ho-doped silica glass has been measured. Fluorescence of 1 mol%, 3 mol%, and 6 mol% Ho3+-doped ZBLAN glasses are reported. The effect of cerium and terbium ions on the emission of Ho3+-doped ZBLAN glass has also been studied. Obstacles to achieving an efficient Ho3+-doped ZBLAN laser are analyzed and discussed. In studies of a commercial Ho3+-doped ZBLAN fiber laser, it was found that the 3 μm four-energy-level laser can easily overwhelm the 1.2 μm laser, which is a three-energy-level system having the same upper laser level with the 3 μm laser. In order to effectively suppress the competiting 3 μm transition, advanced Ho3+-doped ZBLAN fiber has been designed and fabricated for 1.2 μm fiber lasers. Fiber lasers at 1.2 μm using the new Ho3+-doped ZBLAN fiber have been developed. Our experiments demonstrate that the new Ho3+-doped ZBLAN fiber is an efficient gain medium for lasers at 1.2 μm.

  3. Crystal structure of 1-(2,4-dimethylphenyl-2-(4-trimethylsilyl-1H-1,2,3-triazol-1-ylethanone

    Directory of Open Access Journals (Sweden)

    G. B. Venkatesh

    2014-12-01

    Full Text Available The asymmetric unit of the title compound, C15H21N3OSi, contains two molecules with similar conformations (r.m.s. overlay fit for the 20 non-H atoms = 0.163 Å. The dihedral angles between the planes of the 1,2,3-triazole and 2,4-dimethylbenzene rings are 27.0 (3 and 19.5 (3°. In the crystal, molecules are linked by very weak C—H...O and C—H...N hydrogen bonds to generate [100] chains. The chains are cross-linked by C—H...π interactions.

  4. Surgery strategy about C1-2 dumbbell tumor%C1-2哑铃型肿瘤的手术治疗

    Institute of Scientific and Technical Information of China (English)

    马长城; 王振宇; 于涛

    2011-01-01

    目的:研究C1-2哑铃型肿瘤的手术方式以及手术对颈椎稳定性的影响.方法:回顾分析北京大学第三医院神经外科2007年1月至2010年7月收治的C1-2哑铃型肿瘤手术病例共16例,根据肿瘤的大小和侵及范围选择不同手术方式切除肿瘤.常规病人先行俯卧位,首先行后正中半椎板人路切除椎管内外肿瘤,充分显露肿瘤后,切除硬膜外部分,待有足够空间,再切除硬膜下部分;如果肿瘤在椎管内部分超过椎管的一半以上,则须切除部分C1-2棘突基底以利显露手术区域,以防脊髓损伤.硬膜如有缺损则需修补,肌肉缝合要做到解剖复位,以利颈椎的稳定性;如果肿瘤侵及椎管外超过4 cm或完全包绕椎动脉Ⅰ期手术无法全切,则需再联合侧方人路切除肿瘤.结果:共治疗C1-2哑铃型肿瘤16例,其中神经鞘瘤12例,脊膜瘤3例,神经节细胞瘤1例;全切除14例,次全切除2例.病人术后颈部疼痛、上肢肌肉无力等症状均有明显缓解.术后随访3~48个月,未出现颈椎不稳定和肿瘤复发.结论:后正中半椎板入路或联合侧方入路能较好地切除C1-2哑铃型肿瘤,同时能较好地保持颈椎的稳定性.%Objective : To study the operation of C1-2 dumbbell-shaped tumor, and its effect on the cervical spine stability. Methods: Different surgical tumor resection was selected according to the tumor size and the invasion scope. Hemilaminectomy was the first choice for the resection of the tumor at intr-extraspinal canal in the conventional prone position . After the tumor was fully revealed, the epidural tumor was removed first with enough space to be vacated, then the subdural section was removed . If the tumor in the spinal canal was more than half of the spinal canal, to prevent spinal cord injury, the part of the C1-2 spinous process base should be removed to facilitate the exposure. Dural defect should be repaired and the muscle sutured to achieve anatomic reduction

  5. Method of JQuery Mobile 1.2 in mobile Web development%JQuery Mobile 1.2移动Web开发方法研究

    Institute of Scientific and Technical Information of China (English)

    徐尤华; 熊传玉

    2013-01-01

    With the rapidly growing popularity of smart devices such as iphone and Android,mobile web technology has gradually become a new hot spot of concern,traditional site will be transferred to the mobile terminal due to market demand.Traditional website can not adapt to terminal,mobile web development is becoming a popular subject.JQuery Mobile 1.2 final released on October,2012,has many advantages,such as to get started quickly,support rapid iteration,support cross-platform and crossdevice development.Will become a main UI frame in mobile web development.Understand features,accessibility,supported plafforms of JQuery Mobile 1.2,the scope of the framework can be clearly.Master pages,dialogs,toolbars,buttons,content formatting,form elements,list views,API and other content,you can create a functional and beautiful mobile web page quickly.%随着iphone、Android等智能设备的迅速普及,移动Web技术逐渐成为关注的新热点,传统信息类和电子商务网站因市场需求向移动终端转移.由于传统网站在终端不能很好地适应,移动Web开发逐渐成为一门热门学科.JQuery Mobile 1.2正式版于2012年10月正式发布,其具有上手迅速并支持快速迭代、支持跨平台和跨设备开发等优点,将会成为移动Web开发中UI开发的主流框架.通过对JQuery Mobile 1.2的主要特性、易用性、支持的平台的了解,可以明确该框架的适用范围.掌握页面、对话框、工具栏、按钮、内容格式化、表单元素、列表、API等主要内容后,可以快速制作出实用且漂亮的移动Web页面.

  6. Ethyl 4-({1-[2-(4-bromophenyl-2-oxoethyl]-1H-1,2,3-triazol-4-yl}methoxy-8-(trifluoromethylquinoline-3-carboxylate

    Directory of Open Access Journals (Sweden)

    Arun M. Islor

    2012-12-01

    Full Text Available The title compound, C24H18BrF3N4O4, is a 1,2,3-triazole derivative featuring, among others, a quinoline-derived substituent. In the crystal, C—H...O, C—H...N and C—H...F contacts connect the molecules into a three-dimensional network. The shortest centroid–centroid distance between two aromatic systems is 3.896 (2 Å and is found between the two different six-membered rings of the quinoline scaffold in neighbouring molecules.

  7. Isaiah 1:2−3, ethics and wisdom. Isaiah 1:2–3 and the Song of Moses (Dt 32: Is Isaiah a prophet like Moses?

    Directory of Open Access Journals (Sweden)

    Alphonso Groenewald

    2011-06-01

    Full Text Available This article argued that society even today could benefit from the richness of the ethics of the Hebrew Bible. Isaiah 1:2–3 has been used as an example to illustrate the ethics of a biblical text. This text has wisdom traits and literary links with Deuteronomy 32. In a modern, pluralistic society there is a need for a comprehensive ethical view by which one can combine a solid religious foundation, including responsibility towards God, the Creator and Lord of life, with a broad human wisdom gained from a rational understanding of the circumstances of existence for a true human life in a created world of order.

  8. Growth kinetics of indium metal atoms on Si(1 1 2) surface

    Energy Technology Data Exchange (ETDEWEB)

    Raj, Vidur; Chauhan, Amit Kumar Singh; Gupta, Govind, E-mail: govind@nplindia.org

    2015-12-15

    Graphical abstract: Controlled growth of indium atoms on Si(1 1 2) surface has been carried out systematically and the influence of substrate temperature on the kinetics is analysed under various growth conditions. Temperature induced anomalous layer-to-clusters transformation during thermal desorption has also been reported. - Highlights: • Controlled growth of indium atoms on Si(1 1 2) surface & their thermal stability. • Influence of substrate temperature on the kinetics under various growth conditions. • Temperature induced layer-to-clusters transformation during thermal desorption. - Abstract: The growth kinetics and desorption behavior of indium (In) atoms grown on high index Si(1 1 2) surface at different substrate temperatures has been studied. Auger electron spectroscopy analysis revealed that In growth at room temperature (RT) and high substrate temperature (HT) ∼250 °C follows Frank–van der Merve growth mode whereas at temperatures ≥450 °C, In growth evolves through Volmer–Weber growth mode. Thermal desorption studies of RT and 250 °C grown In/Si(1 1 2) systems show temperature induced rearrangement of In atoms over Si(1 1 2) surface leading to clusters to layer transformation. The monolayer and bilayer desorption energies for RT grown In/Si(1 1 2) system are calculated to be 2.5 eV and 1.52 eV, while for HT-250 °C the values are found to be 1.6 eV and 1.3 eV, respectively. This study demonstrates the effect of temperature on growth kinetics as well as on the multilayer/monolayer desorption pathway of In on Si(1 1 2) surface.

  9. Isolation and characterization of tetrachloroethylene- and cis-1,2-dichloroethylene-dechlorinating propionibacteria.

    Science.gov (United States)

    Chang, Young-Cheol; Ikeutsu, Kaori; Toyama, Tadashi; Choi, Dubok; Kikuchi, Shintaro

    2011-10-01

    Two rapidly growing propionibacteria that could reductively dechlorinate tetrachloroethylene (PCE) and cis-1,2-dichloroethylene (cis-DCE) to ethylene were isolated from environmental sediments. Metabolic characterization and partial sequence analysis of their 16S rRNA genes showed that the new isolates, designated as strains Propionibacterium sp. HK-1 and Propionibacterium sp. HK-3, did not match any known PCE- or cis-DCE-degrading bacteria. Both strains dechlorinated relatively high concentrations of PCE (0.3 mM) and cis-DCE (0.52 mM) under anaerobic conditions without accumulating toxic intermediates during incubation. Cell-free extracts of both strains catalyzed PCE and cis-DCE dechlorination; degradation was accelerated by the addition of various electron donors. PCE dehalogenase from strain HK-1 was mediated by a corrinoid protein, since the dehalogenase was inactivated by propyl iodide only after reduction by titanium citrate. The amounts of chloride ions (0.094 and 0.103 mM) released after PCE (0.026 mM) and cis-DCE (0.05 mM) dehalogenation using the cell-free enzyme extracts of both strains, HK-1 and HK-3, were stoichiometrically similar (91 and 100%), indicating that PCE and cis-DCE were fully dechlorinated. Radiotracer studies with [1,2-¹⁴C] PCE and [1,2-¹⁴C] cis-DCE indicated that ethylene was the terminal product; partial conversion to ethylene was observed. Various chlorinated aliphatic compounds (PCE, trichloroethylene, cis-DCE, trans-1,2-dichloroethylene, 1,1-dichloroethylene, 1,1-dichloroethane, 1,2-dichloroethane, 1,2-dichloropropane, 1,1,2-trichloroethane, and vinyl chloride) were degraded by cell-free extracts of strain HK-1.

  10. Sigma-1 receptor agonists directly inhibit Nav1.2/1.4 channels.

    Directory of Open Access Journals (Sweden)

    Xiao-Fei Gao

    Full Text Available (+-SKF 10047 (N-allyl-normetazocine is a prototypic and specific sigma-1 receptor agonist that has been used extensively to study the function of sigma-1 receptors. (+-SKF 10047 inhibits K(+, Na(+ and Ca2+ channels via sigma-1 receptor activation. We found that (+-SKF 10047 inhibited Na(V1.2 and Na(V1.4 channels independently of sigma-1 receptor activation. (+-SKF 10047 equally inhibited Na(V1.2/1.4 channel currents in HEK293T cells with abundant sigma-1 receptor expression and in COS-7 cells, which barely express sigma-1 receptors. The sigma-1 receptor antagonists BD 1063,BD 1047 and NE-100 did not block the inhibitory effects of (+-SKF-10047. Blocking of the PKA, PKC and G-protein pathways did not affect (+-SKF 10047 inhibition of Na(V1.2 channel currents. The sigma-1 receptor agonists Dextromethorphan (DM and 1,3-di-o-tolyl-guanidine (DTG also inhibited Na(V1.2 currents through a sigma-1 receptor-independent pathway. The (+-SKF 10047 inhibition of Na(V1.2 currents was use- and frequency-dependent. Point mutations demonstrated the importance of Phe(1764 and Tyr(1771 in the IV-segment 6 domain of the Na(V1.2 channel and Phe(1579 in the Na(V1.4 channel for (+-SKF 10047 inhibition. In conclusion, our results suggest that sigma-1 receptor agonists directly inhibit Na(V1.2/1.4 channels and that these interactions should be given special attention for future sigma-1 receptor function studies.

  11. Structural and electrical properties of Na{sub 1/2}La{sub 1/2}TiO{sub 3} ceramics

    Energy Technology Data Exchange (ETDEWEB)

    Barik, S.K.; Mahapatra, P.K. [Vidyasagar University, Department of Physics and Technophysics, Midnapur, West Bengal (India); Choudhary, R.N.P. [Department of Physics and Meteorology, I.I.T. Kharagpur (India)

    2006-11-15

    Na{sub 1/2}La{sub 1/2}TiO{sub 3} (NLT) ceramic was prepared by a high-temperature solid-state reaction technique. A preliminary structural analysis (XRD) suggested the formation of a single-phase orthorhombic structure. SEM micrograph of the material showed uniform grain distribution on the surface of the sample. The dielectric permittivity and the loss tangent of the sample were measured in a frequency range from 1 kHz to 1 MHz and a temperature range 28 C to 525 C. Electrical properties of the material were studied using an ac impedance spectroscopic technique. Detailed analysis of the impedance spectrum suggested that the electrical properties of the material are strongly temperature dependant. The Nyquist plots clearly showed the presence of both bulk and grain boundary effect in the compound. The activation energy was estimated to be 1.1 eV from the temperature variation of dc conductivity. The a.c. conductivity spectrum suggests a typical signature of ion conducting system. (orig.)

  12. Impedance spectroscopy study of Na{sub 1/2}Sm{sub 1/2}TiO{sub 3} ceramic

    Energy Technology Data Exchange (ETDEWEB)

    Barik, S.K.; Choudhary, R.N.P. [I.I.T., Department of Physics and Meteorology, Kharagpur (India); Mahapatra, P.K. [Vidyasagar University, Department of Physics and Technophysics, Midnapur, West Bengal (India)

    2007-07-15

    Complex impedance analysis of a valence-compensated perovskite ceramic oxide Na{sub 1/2}Sm{sub 1/2}TiO{sub 3}, prepared by a mixed oxide (solid-state reaction) method, has been carried out. The formation of single-phase material was confirmed by X-ray diffraction studies, and it was found to be an orthorhombic phase at room temperature. In a scanning electron microscope, grains separated by well-defined boundaries are visible, which is in good agreement with that of impedance analysis. Alternating current impedance measurements were made over a wide temperature range (31-400 C) in an air atmosphere. Complex impedance and modulus plots helped to separate out the contributions of grain and grain boundaries to the overall polarization or electrical behavior. The physical structure of the samples was visualized most prominently at higher temperatures (275 C) from the Nyquist plots showing inter- and intragranular impedance present in the material. The frequency dependence of electrical data is also analyzed in the framework of the conductivity and modulus formalisms. The bulk resistance, evaluated from the impedance spectrum, was observed to decrease with rise in temperature, showing a typical negative temperature coefficient of resistance-type behavior like that of semiconductors. The modulus mechanism indicates the non-Debye type of conductivity relaxation in the materials, which is supported by the impedance data. (orig.)

  13. Structural and electrical properties of Na{sub 1/2}Gd{sub 1/2}TiO{sub 3} nanoceramics

    Energy Technology Data Exchange (ETDEWEB)

    Barik, Subrat K. [Department of Physics and Meteorology, IIT Kharagpur, Kharagpur 721302 (India); Choudhary, R.N.P. [Department of Physics and Meteorology, IIT Kharagpur, Kharagpur 721302 (India)], E-mail: crnpfl@phy.iitkgp.ernet.in; Mahapatra, P.K. [Department of Physics and Technophysics, Vidyasagar University, Midnapur 721102, West Bengal (India)

    2008-07-14

    The polycrystalline fine (i.e., 38 nm) powder of Na{sub 1/2}Gd{sub 1/2}TiO{sub 3} was prepared by a high-temperature solid-state reaction technique. The formation of single phase compound was confirmed by an X-ray diffraction technique. A preliminary structural analysis exhibited the orthogonal crystal structure of the compound. The surface morphology was studied by scanning electron microscopy. The dielectric permittivity and the loss tangent of the pellet sample were obtained in a wide frequency range (1 kHz-1 MHz) at different temperatures (28-500 deg. C). A dielectric anomaly was observed at 73 deg. C which may be related to ferroelectric-paraelectric phase transition. The ferroelectric transition was confirmed by observation of hysteresis loop at room temperature. Electrical properties of the pellet sample were studied using an AC impedance spectroscopic technique. Detailed analysis of impedance spectra indicated the bulk contribution to electrical properties below 375 deg. C, and the grain boundary above 375 deg. C. The negative temperature coefficient of resistance (NTCR) effect and the temperature dependant electrical relaxation phenomenon in the sample were also observed. Studies of DC conductivity exhibited that the material has a thermally activated process. AC conductivity spectrum obeys Jonscher's universal power law.

  14. Studies of Thermal, Impedance and Magnetic Properties of (Bi1/2Na1/2)(Fe2/3W1/3)O3 Multiferroics

    Science.gov (United States)

    Ahmed, Suhel; Barik, Subrat Kumar

    2017-02-01

    A polycrystalline sample of (Bi1/2Na1/2)(Fe2/3W1/3)O3 was synthesized by high-temperature solid-state reaction technique. Calcination temperature and thermal stability of the material were analyzed by thermogravimetric analysis. X-ray diffraction analysis reveals a phase transformation from rhombohedral to orthorhombic due to Na and W co-doping in BFO. Electrical properties of the material were measured in a wide temperature range of 30-450°C, at different frequencies (100 Hz-1 MHz). Dielectric study revealed that the prepared material had a Neel temperature at 325°C. Direct current conductivity was found to obey the Arrhenius relationship. The value of activation energy was found to be 0.67 eV for the grain (175-450°C) and 0.94 eV for the grain boundary (200-450°C). The enhanced magnetic property of the synthesized material was evaluated from the magnetization-magnetic field loop study.

  15. Chemical pressure induced change in multiferroicity of Bi1+2xGd2x/2Fe1-2xO3 bulk ceramics

    Science.gov (United States)

    Pradhan, S. K.; Sahu, D. R.; Rout, P. P.; Das, S. K.; Pradhan, A. K.; Srinivasu, V. V.; Roul, B. K.

    2017-04-01

    We have optimized Gd ion substitution in BiFeO3 (BFO) and observed prominently change in structural, electrical and magnetic behavior of Bi1+2xGd2x/2Fe1-2xO3 ceramics synthesized through slow step sintering schedule. It is observed that with the increase in concentration of Gd (x=0.1), original structure of BFO is transformed from rhombohedral R3c space group to orthorhombic Pn21a space group. Surprisingly, unit cell volume is drastically contracted (35% for x=0.2) and the sintered specimen showed enhanced room temperature ferromagnetic behavior although the original BFO is normally G-type antiferromagnetic in nature at 643 K. It is expected that intrinsic chemical pressure within the bulk body built by the substitution of Gd in presence of excess bismuth greatly supported through unidirectional movement of electrical dipole moment with in each individual domain as a result of which suppression of leakage current with enhanced dielectric and ferroelectric hysteresis is observed.

  16. Fabrication and Electrical Properties of Multilayer Ceramic Actuator Using Lead-Free (Bi1/2K1/2)TiO3

    Science.gov (United States)

    Nagata, Hajime; Tabuchi, Kazuya; Takenaka, Tadashi

    2013-09-01

    A prototype of a multilayer actuator (MLA) was fabricated using (Bi1/2K1/2)TiO3 (BKT) ceramics as active layers and Ag-Pd (7:3) as inner electrodes. Then, their microstructures and electrical properties were investigated. From the scanning electron microscope (SEM) observation, the thickness of the BKT active layers between electrodes was estimated to be approximately 60 µm for the body co-fired at 1045 °C for 10 h. Also, SEM images showed homogeneous and dense microstructures on the BKT active layers. Additionally, the interface between BKT and the Ag-Pd electrode was clearly distinguished and there are no significant signs of reaction or diffusion between them at least from the SEM micrographs. The resistivity ρ of BKT sample co-fired at 1045 °C for 10 h was about 1011 Ω.cm on average, which is sufficient for applying a high DC electric field to the sample. From the measurement of the field-induce strain S under unipolar driving at 100 kV/cm, a large strain of 0.14% at 100 kV/cm was obtained and the longitudinal dynamic displacement was 1 µm at the same electric field. The normalized d33* was calculated to be 138 pm/V, which is similar to that in the bulk samples. This result indicates that the BKT-based multilayered prototype efficiently functioned under unipolar driving up to 100 kV/cm.

  17. Structural transitions in Pb(In1/2Nb1/2)O 3 under pressure

    Energy Technology Data Exchange (ETDEWEB)

    Ahart, Muhtar [Carnegie Inst. of Washington, Washington, DC (United States); Somayazulu, Maddury [Carnegie Inst. of Washington, Washington, DC (United States); Kojima, Seiji [Gifu Univ. (Japan); Yasuda, Naohiko [Gifu Univ. (Japan); Prosandeev, Sergey [Univ. of Arkansas, Fayetteville, AR (United States). Inst. for Nanoscience and Engineering; Hemley, Russell J. [Carnegie Inst. of Washington, Washington, DC (United States)

    2015-12-01

    Room-temperature Raman scattering and x-ray diffraction measurements together with first-principles calculations were employed to investigate the behavior of disordered Pb(In1/2Nb1/2)O3 (PIN) under pressure up to 50GPa. Raman spectra show broad bands but a peak near the 380cm-1 increases its intensity with pressure. The linewidth of the band at 550cm-1 also increases with pressure, while two of the Raman peaks merge above 6GPa. Above 16GPa, we observe additional splitting of the band at 50cm-1. The pressure evolution of the diffraction patterns for PIN shows obvious Bragg peaks splitting above 16GPa; consistent with a symmetry lowering transition. The transition at 0.5GPa is identified as a pseudo-cubic to orthorhombic (Pbam) structural change whereas the transition at 16GPa is isostructure and associated with changes in linear compressibility and octahedral titling, and the transition at 30GPa is associated to an orthorhombic to monoclinic change. First-principles calculations indicate that the Pbam structure is ground state with antiferrodisdortion consistent with experiment.

  18. Combination of 1,2,4-Oxadiazole and 1,2,5-Oxadiazole Moieties for the Generation of High-Performance Energetic Materials.

    Science.gov (United States)

    Wei, Hao; He, Chunlin; Zhang, Jiaheng; Shreeve, Jean'ne M

    2015-08-03

    Salts generated from linked 1,2,4-oxadiazole/1,2,5-oxadiazole precursors exhibit good to excellent thermal stability, density, and, in some cases, energetic performance. The design of these compounds was based on the assumption that by the combination of varying oxadiazole rings, it would be possible to profit from the positive aspects of each of the components. All of the new compounds were fully characterized by elemental analysis, IR spectroscopy, (1)H, (13)C, and (in some cases) (15)N NMR spectroscopy, and thermal analysis (DSC). The structures of 2-3 and 5-1⋅5 H2O were confirmed by single-crystal X-ray analysis. Theoretical performance calculations were carried out by using Gaussian 03 (Revision D.01). Compound 2-3, with its good density (1.85 g cm(-3)), acceptable sensitivity (14 J, 160 N), and superior detonation pressure (37.4 GPa) and velocity (9046 m s(-1)), exhibits performance properties superior to those of 1,3,5-trinitroperhydro-1,3,5-triazine (RDX). © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Effect of thermal history on stability of the relaxor state in (Bi1/2K1/2)TiO3 ceramics

    Science.gov (United States)

    Hagiwara, Manabu; Fujihara, Shinobu

    2017-10-01

    Bismuth potassium titanate (Bi1/2K1/2)TiO3 (BKT) with disordered A-site Bi3+ and K+ ions is known to undergo a spontaneous phase transition between a high-temperature relaxor (R) state and a low-temperature ferroelectric (FE) state at around 300 °C. Here, we demonstrate that the thermal history of BKT ceramics has a great effect on the stability of the R and FE states. To modulate the distribution of Bi3+ and K+ ions, as-sintered BKT ceramics were postannealed at 900 °C and then cooled to 500 °C at a very low cooling rate of ‑0.1 °C/min. The slowly cooled samples showed a normal-relaxor-like temperature dependence of dielectric permittivity without any anomaly attributed to the spontaneous R-FE transition. The slow cooling treatment changed the room-temperature crystal system of the BKT ceramics from tetragonal to cubic, although it did not induce the cationic ordering of Bi3+ and K+. It was also observed that the macroscopic domain structure disappeared after the slow cooling treatment. These observations demonstrated that the slow cooling treatment stabilized the R state in BKT to inhibit the spontaneous phase transition into the FE state. The possible reason for the stabilization of the R state in the slowly cooled BKT is discussed on the basis of the changes in cationic distribution and local compositional heterogeneity.

  20. Dielectric and Magnetic Properties of Ba(Fe1/2Ta1/2)O3-BiFeO3 Ceramics

    Science.gov (United States)

    Manotham, S.; Butnoi, P.; Jaita, P.; Pinitsoontorn, S.; Sweatman, D.; Eitssayeam, S.; Pengpat, K.; Rujijanagul, G.

    2016-11-01

    The properties of (1- x)Ba(Fe1/2Ta1/2)O3- xBiFeO3 [(1- x)BFT- xBFO] ( x = 0.0, 0.1, 0.3, 0.5) ceramics have been investigated. (1- x)BFT- xBFO powders were synthesized by a modified two-step calcination technique, and ceramics were fabricated by a conventional technique. X-ray diffraction (XRD) analysis revealed that the modified ceramics exhibited a mixture of BFT cubic phase and BFO rhombohedral phase. The peaks shift increased with increasing BFO content to a maximum value for the composition with x = 0.5. The overall shift of the XRD patterns indicated distortion of the unit cell, which may be due to ions from BFO entering the BFT lattice. BFO additive promoted grain growth, while the maximum density of the studied ceramics was observed for the x = 0.1 composition. The modified ceramics presented enhanced thermal and frequency stability of the dielectric constant. BFO additive also reduced the loss tangent for the system. Improvement of the magnetic behavior was observed after adding BFO. Furthermore, all the ceramics, including pure BFT (a nonmagnetic phase at room temperature), presented a magnetocapacitance effect, which can be related to magnetoresistance along with Maxwell-Wagner polarization effects.

  1. Reconciling Local Structure Disorder and the Relaxor State in (Bi1/2Na1/2)TiO3-BaTiO3

    Science.gov (United States)

    Groszewicz, Pedro B.; Gröting, Melanie; Breitzke, Hergen; Jo, Wook; Albe, Karsten; Buntkowsky, Gerd; Rödel, Jürgen

    2016-08-01

    Lead-based relaxor ferroelectrics are key functional materials indispensable for the production of multilayer ceramic capacitors and piezoelectric transducers. Currently there are strong efforts to develop novel environmentally benign lead-free relaxor materials. The structural origins of the relaxor state and the role of composition modifications in these lead-free materials are still not well understood. In the present contribution, the solid-solution (100-x)(Bi1/2Na1/2)TiO3-xBaTiO3 (BNT-xBT), a prototypic lead-free relaxor is studied by the combination of solid-state nuclear magnetic resonance (NMR) spectroscopy, dielectric measurements and ab-initio density functional theory (DFT). For the first time it is shown that the peculiar composition dependence of the EFG distribution width (ΔQISwidth) correlates strongly to the dispersion in dielectric permittivity, a fingerprint of the relaxor state. Significant disorder is found in the local structure of BNT-xBT, as indicated by the analysis of the electric field gradient (EFG) in 23Na 3QMAS NMR spectra. Aided by DFT calculations, this disorder is attributed to a continuous unimodal distribution of octahedral tilting. These results contrast strongly to the previously proposed coexistence of two octahedral tilt systems in BNT-xBT. Based on these results, we propose that considerable octahedral tilt disorder may be a general feature of these oxides and essential for their relaxor properties.

  2. Synthesis of Catechol by Dehydrogenation of 1,2-Cyclohexanediol%1,2-环己二醇催化脱氢制备邻苯二酚

    Institute of Scientific and Technical Information of China (English)

    谢英男; 章亚东; 蒋登高

    2005-01-01

    用均相沉淀法制备了Ni/硅藻土催化剂,用于催化1,2-环己二醇脱氢制备邻苯二酚,并用浸渍法添加Na+作为助剂,在微分反应器里考察了活性组分Ni含量、助催化剂Na含量、还原时间、反应温度、催化剂负荷等因素对反应的影响,确定了反应产物的气相色谱分析条件.当催化剂中w(Ni)=20%、w(Na)=4%、反应温度320 ℃、液时空速为9 h-1时,1,2-环己二醇转化率>95%,邻苯二酚收率>85%.

  3. Structural and impedance spectroscopy analysis of Ba(Fe{sub 1/2}Nb{sub 1/2})O{sub 3} ceramic

    Energy Technology Data Exchange (ETDEWEB)

    Bhagat, S.; Prasad, K. [Materials Research Laboratory, University Department of Physics, T.M. Bhagalpur University, Bhagalpur 812 007 (India)

    2010-05-15

    Lead-free perovskite Ba(Fe{sub 1/2}Nb{sub 1/2})O{sub 3} (BFN) was prepared by conventional ceramic fabrication technique at 1200 C/5 h in air atmosphere. The crystal symmetry, space group, and unit cell dimensions were determined from the experimental results using FullProf software whereas crystallite size and lattice strain were estimated from Williamson-Hall approach. X-ray diffraction (XRD) analysis of the compound indicated the formation of a single-phase monoclinic structure with the space group P2/m. EDAX and SEM studies were carried out in order to evaluate the quality and purity of the compound. To find a correlation between the response of the real system and idealized model circuit composed of discrete electrical components, the model fittings were presented using the impedance data. Complex impedance analyses suggested the dielectric relaxation to be of non-Debye type. The correlated barrier hopping (CBH) model was employed to successfully explain the mechanism of charge transport in BFN. (Abstract Copyright [2010], Wiley Periodicals, Inc.)

  4. P2-type Na(x)[Fe(1/2)Mn(1/2)]O2 made from earth-abundant elements for rechargeable Na batteries.

    Science.gov (United States)

    Yabuuchi, Naoaki; Kajiyama, Masataka; Iwatate, Junichi; Nishikawa, Heisuke; Hitomi, Shuji; Okuyama, Ryoichi; Usui, Ryo; Yamada, Yasuhiro; Komaba, Shinichi

    2012-04-29

    Rechargeable lithium batteries have risen to prominence as key devices for green and sustainable energy development. Electric vehicles, which are not equipped with an internal combustion engine, have been launched in the market. Manganese- and iron-based positive-electrode materials, such as LiMn(2)O(4) and LiFePO(4), are used in large-scale batteries for electric vehicles. Manganese and iron are abundant elements in the Earth's crust, but lithium is not. In contrast to lithium, sodium is an attractive charge carrier on the basis of elemental abundance. Recently, some layered materials, where sodium can be electrochemically and reversibly extracted/inserted, have been reported. However, their reversible capacity is typically limited to 100 mAh g(-1). Herein, we report a new electrode material, P2-Na(2/3)[Fe(1/2)Mn(1/2)]O(2), that delivers 190 mAh g(-1) of reversible capacity in the sodium cells with the electrochemically active Fe(3+)/Fe(4+) redox. These results will contribute to the development of rechargeable batteries from the earth-abundant elements operable at room temperature.

  5. P2-type Nax[Fe1/2Mn1/2]O2 made from earth-abundant elements for rechargeable Na batteries

    Science.gov (United States)

    Yabuuchi, Naoaki; Kajiyama, Masataka; Iwatate, Junichi; Nishikawa, Heisuke; Hitomi, Shuji; Okuyama, Ryoichi; Usui, Ryo; Yamada, Yasuhiro; Komaba, Shinichi

    2012-06-01

    Rechargeable lithium batteries have risen to prominence as key devices for green and sustainable energy development. Electric vehicles, which are not equipped with an internal combustion engine, have been launched in the market. Manganese- and iron-based positive-electrode materials, such as LiMn2O4 and LiFePO4, are used in large-scale batteries for electric vehicles. Manganese and iron are abundant elements in the Earth’s crust, but lithium is not. In contrast to lithium, sodium is an attractive charge carrier on the basis of elemental abundance. Recently, some layered materials, where sodium can be electrochemically and reversibly extracted/inserted, have been reported. However, their reversible capacity is typically limited to 100 mAh g-1. Herein, we report a new electrode material, P2-Na2/3[Fe1/2Mn1/2]O2, that delivers 190 mAh g-1 of reversible capacity in the sodium cells with the electrochemically active Fe3+/Fe4+ redox. These results will contribute to the development of rechargeable batteries from the earth-abundant elements operable at room temperature.

  6. Electrical Properties of Textured (Bi1/2K1/2)TiO3-BaTiO3 Lead-Free Piezoelectric Ceramics

    Science.gov (United States)

    Nemoto, Masahiro; Hiruma, Yuji; Nagata, Hajime; Takenaka, Tadashi

    2009-07-01

    The electrical properties of (1-x)(Bi1/2K1/2)TiO3-xBaTiO3 (BKT-BT100x) ceramics prepared by an ordinary solid-state reaction and a reactive templated grain growth (RTGG) method using platelike Bi4Ti3O12 particles as a template were investigated. The degree of orientation, F, which was determined by the Lotgering method using an X-ray diffraction pattern, achieved ≈83% in the textured BKT-BT10 ceramic. A textured BKT-BT10 ceramic with a homogeneous microstructure was obtained after a long sintering time. The field-induced strains and piezoelectric properties of the BKT-BT10 ceramic were improved by improving grain orientation. In particular, the piezoelectric strain constant, d33, and the normalized strain, d33*, of the textured BKT-BT10 ceramic in the direction parallel (∥) to the tape stacking direction were 121 pC/N and 211 pm/V (at 80 kV/cm), respectively.

  7. Fabrication and Piezoelectric Properties of Grain-Oriented (Bi1/2K1/2)TiO3-BaTiO3 Ceramics

    Science.gov (United States)

    Nemoto, Masahiro; Hiruma, Yuji; Nagata, Hajime; Takenaka, Tadashi

    2008-05-01

    The piezoelectric properties of (1 - x)(Bi1/2K1/2)TiO3-xBaTiO3 (x = 0.1) [abbreviated as BKT-BT10] ceramics prepared by ordinary solid-state reaction and reactive templated grain growth (RTGG) using platelike Bi4Ti3O12 particles as a template were investigated. All samples showed a single-phase perovskite structure, and relative densities compared with theoretical densities were all higher than 95%. The degree of orientation F was determined by the Lotgering method using an X-ray diffraction (XRD) pattern. The F values of textured BKT-BT10 ceramics were relatively low at ˜35%. However, field-induced strains and piezoelectric properties of BKT-BT10 ceramics were improved by grain orientation. In particular, the piezoelectric strain constant d33 and the strain of textured BKT-BT10 ceramics in a direction parallel (∥) to the tape stacking direction were 84.5 pC/N and 168 pm/V (at 80 kV/cm), respectively.

  8. Seroprevalencia de HTLV-1/2 en donantes de sangre de la Provincia de Misiones Seroprevalence of HTLV-1/2 in blood donors from Misiones Province

    Directory of Open Access Journals (Sweden)

    Richard Malan

    2010-02-01

    Full Text Available El Virus Linfotrópico T Humano tipo 1 (HTLV-1, primer oncorretrovirus humano descubierto, es el causante etiológico de la leucemia de células T del adulto (ATL y de la mielopatía asociada al HTLV-1 o paraparesia espástica tropical (HAM/TSP. Es endémico en distintas partes del mundo, inclusive en el noroeste argentino, donde ambas enfermedades fueron detectadas. El HTLV-2, no tiene un rol etiológico definido, si bien ha sido asociado con síndromes neurológicos similares a la HAM/TSP. Ambos virus son endémicos en comunidades originarias del continente americano, tribus de Africa y poblaciones en riesgo. Ambos retrovirus se transmiten por vía sexual, parenteral y de madre a hijo. El objetivo de este trabajo fue determinar la seroprevalencia de HTLV-1/2 en una población de donantes de sangre de la provincia de Misiones. Se analizaron 6912 donaciones de sangre recibidas en el Banco de Sangre Central de la Provincia de Misiones durante 2008. La detección de anticuerpos se realizó por ELISA y aglutinación de partículas, y las muestras reactivas fueron confirmadas por Western Blot. Del total de muestras, 5 resultaron seropositivas con una prevalencia final de 0.00072. De ellas, una era HTLV, tres HTLV-1 y una HTLV-2 positiva. Los donantes positivos provenían de Posadas, Eldorado y Oberá, sin antecedentes de riesgo. Este estudio demuestra la presencia de HTLV-1/2 en donantes de sangre de Misiones, con cifras similares a las notificadas en donantes de sangre de zonas no endémicas.Human T-cell Lymphotropic viruses type 1 (HTLV-1, the first human oncoretrovirus to be discovered, is the etiologic agent of Adult T-cell Leukemia (ATL and HTLV-1 Associated Mielopathy or Tropical Spastic Paraparesis (HAM/TSP. It is endemic worldwide, including the North of Argentina where both associated diseases have also been detected. No etiologic role has been described for HTLV-2, although it has been associated with HAM/TSP-like neurologic syndromes

  9. Phasic phosphorylation of caldesmon and ERK 1/2 during contractions in human myometrium.

    Science.gov (United States)

    Paul, Jonathan; Maiti, Kaushik; Read, Mark; Hure, Alexis; Smith, Julia; Chan, Eng-Cheng; Smith, Roger

    2011-01-01

    Human myometrium develops phasic contractions during labor. Phosphorylation of caldesmon (h-CaD) and extracellular signal-regulated kinase 1/2 (ERK 1/2) has been implicated in development of these contractions, however the phospho-regulation of these proteins is yet to be examined during periods of both contraction and relaxation. We hypothesized that protein phosphorylation events are implicated in the phasic nature of myometrial contractions, and aimed to examine h-CaD and ERK 1/2 phosphorylation in myometrium snap frozen at specific stages, including; (1) prior to onset of contractions, (2) at peak contraction and (3) during relaxation. We aimed to compare h-CaD and ERK 1/2 phosphorylation in vitro against results from in vivo studies that compared not-in-labor (NIL) and laboring (L) myometrium. Comparison of NIL (n = 8) and L (n = 8) myometrium revealed a 2-fold increase in h-CaD phosphorylation (ser-789; P = 0.012) during onset of labor in vivo, and was associated with significantly up-regulated ERK2 expression (P = 0.022), however no change in ERK2 phosphorylation was observed (P = 0.475). During in vitro studies (n = 5), transition from non-contracting tissue to tissue at peak contraction was associated with increased phosphorylation of both h-CaD and ERK 1/2. Furthermore, tissue preserved at relaxation phase exhibited diminished levels of h-CaD and ERK 1/2 phosphorylation compared to tissue preserved at peak contraction, thereby producing a phasic phosphorylation profile for h-CaD and ERK 1/2. h-CaD and ERK 1/2 are phosphorylated during myometrial contractions, however their phospho-regulation is dynamic, in that h-CaD and ERK 1/2 are phosphorylated and dephosphorylated in phase with contraction and relaxation respectively. Comparisons of NIL and L tissue are at risk of failing to detect these changes, as L samples are not necessarily preserved in the midst of an active contraction.

  10. Systematically engineering Escherichia coli for enhanced production of 1,2-propanediol and 1-propanol.

    Science.gov (United States)

    Jain, Rachit; Sun, Xinxiao; Yuan, Qipeng; Yan, Yajun

    2015-06-19

    The biological production of high value commodity 1,2-propanediol has been established by engineering the glycolysis pathway. However, the simultaneous achievement of high titer and high yield has not been reported yet, as all efforts in increasing the titer have resulted in low yields. In this work, we overcome this limitation by employing an optimal minimal set of enzymes, channeling the carbon flux into the 1,2-propanediol pathway, increasing NADH availability, and improving the anaerobic growth of the engineered Escherichia coli strain by developing a cell adaptation method. These efforts lead to 1,2-propanediol production at a titer of 5.13 g/L with a yield of 0.48 g/g glucose in 20 mL shake flask studies. On this basis, we pursue the enhancement of 1-propanol production from the 1,2-propanediol platform. By constructing a fusion diol dehydratase and developing a dual strain process, we achieve a 1-propanol titer of 2.91 g/L in 20 mL shake flask studies. To summarize, we report the production of 1,2-propanediol at enhanced titer and enhanced yield simultaneously in E. coli for the first time. Furthermore, we establish an efficient system for the production of biofuel 1-propanol biologically.

  11. Analysis of isocitrate dehydrogenase-1/2 gene mutations in gliomas

    Institute of Scientific and Technical Information of China (English)

    YU Lei; QI Song-tao; LI Zhi-yong

    2010-01-01

    Objective To highlight recent researches which may show promise for histomolecular classification and new treatments for gliomas.Data sources All articles cited in this review were mainly searched from PubMed, which were published in English from 1996 to 2010.Study selection Original articles and critical reviews selected were relevant to the isocitrate dehydrogenase-1/2 mutation in gliomas and other tumors.Results Extraordinary high rates of somatic mutations in isocitrate dehydrogenase-1/2 occur in the majority of World Health Organization grade Ⅱ and grade Ⅲ gliomas as well as grade Ⅳ secondary glioblastomas. Isocitrate dehydrogenase-1/2 mutations are associated with younger age at diagnosis and a better prognosis in patients with mutated tumors. The functional role of isocitrate dehydrogenase-1/2 mutations in the pathogenesis of gliomas is still unclear.Conclusion Isocitrate dehydrogenase-1/2 mutations define a specific subtype of gliomas and may have great significance in the diagnosis, prognosis, and treatment of patients with these tumors.

  12. Hydrogenolysis of Glycerol to 1,2-Propanediol Over Clay Based Catalysts.

    Science.gov (United States)

    Lee, Sang-Yong; Jung, Jae-Sun; Yang, Eun-Hyeok; Lee, Kwan-Young; Moon, Dong Ju

    2015-11-01

    1,2-propanediol (1,2-PDO) is one of the promising product among the valuable products derived from glycerol and it can be obtained by the catalytic hydrogenolysis of glycerol. Copper-supported clay-based catalysts were prepared with different pore sizes using various ratios of kaolin, Mg, and Al by coprecipitation and applied in the selective hydrogenolysis of glycerol to 1,2-PDO. In recent research, variations of pore volume and pore size could affect the diffusion of reagents within the catalyst due to the collision between reagents or pore wall and reagents. It changes selectivities of each product in hydrogenolysis of glycerol reaction. The physico-chemical properties of the catalysts were analyzed by XRD, N2 physisorption, TPR, CO2-TPD, SEM, and a mercury porosimeter. The Cu/TALCITE 4 catalyst showed 98% 1,2-PDO selectivity with 65% glycerol conversion under the optimized condition of 190 degrees C, 25 bar, and 20 wt% glycerol aqueous solution. It was found that the basic strength and meso-macro pore structure of the catalysts play an important role in glycerol conversion and 1,2-PDO selectivity.

  13. Arabidopsis AIP1-2 restricted by WER-mediated patterning modulates planar polarity.

    Science.gov (United States)

    Kiefer, Christian S; Claes, Andrea R; Nzayisenga, Jean-Claude; Pietra, Stefano; Stanislas, Thomas; Hüser, Anke; Ikeda, Yoshihisa; Grebe, Markus

    2015-01-01

    The coordination of cell polarity within the plane of the tissue layer (planar polarity) is crucial for the development of diverse multicellular organisms. Small Rac/Rho-family GTPases and the actin cytoskeleton contribute to planar polarity formation at sites of polarity establishment in animals and plants. Yet, upstream pathways coordinating planar polarity differ strikingly between kingdoms. In the root of Arabidopsis thaliana, a concentration gradient of the phytohormone auxin coordinates polar recruitment of Rho-of-plant (ROP) to sites of polar epidermal hair initiation. However, little is known about cytoskeletal components and interactions that contribute to this planar polarity or about their relation to the patterning machinery. Here, we show that ACTIN7 (ACT7) represents a main actin isoform required for planar polarity of root hair positioning, interacting with the negative modulator ACTIN-INTERACTING PROTEIN1-2 (AIP1-2). ACT7, AIP1-2 and their genetic interaction are required for coordinated planar polarity of ROP downstream of ethylene signalling. Strikingly, AIP1-2 displays hair cell file-enriched expression, restricted by WEREWOLF (WER)-dependent patterning and modified by ethylene and auxin action. Hence, our findings reveal AIP1-2, expressed under control of the WER-dependent patterning machinery and the ethylene signalling pathway, as a modulator of actin-mediated planar polarity.

  14. Preparation and Antibacterial Properties of Substituted 1,2,4-Triazoles

    Directory of Open Access Journals (Sweden)

    Ionuţ Ledeţi

    2015-01-01

    Full Text Available Background. Both 1,2,3- and 1,2,4-triazoles are nowadays incorporated in numerous antibacterial pharmaceutical formulations. Aim. Our study aimed to prepare three substituted 1,2,4-triazoles and to evaluate their antibacterial properties. Materials and Methods. One disubstituted and two trisubstituted 1,2,4-triazoles were prepared and characterised by physical and spectroscopic properties (melting point, FTIR, NMR, and GC-MS. The antibacterial properties were studied against three bacterial strains: Staphylococcus aureus (ATCC 25923, Escherichia coli (ATCC 25922, and Pseudomonas aeruginosa (ATCC 27853, by the agar disk diffusion method and the dilution method with MIC (minimal inhibitory concentration determination. Results. The spectroscopic characterization of compounds and the working protocol for the synthesis of the triazolic derivatives are described. The compounds were obtained with 15–43% yields and with high purities, confirmed by the NMR analysis. The evaluation of biological activities showed that the compounds act as antibacterial agents against Staphylococcus aureus (ATCC 25923, while being inactive against Escherichia coli (ATCC 25922 and Pseudomonas aeruginosa (ATCC 27853. Conclusions. Our results indicate that compounds containing 1,2,4-triazolic moiety have great potential in developing a wide variety of new antibacterial formulations.

  15. Production of 1,2-didocosahexaenoyl phosphatidylcholine by bonito muscle lysophosphatidylcholine/transacylase.

    Science.gov (United States)

    Hirano, Kaoru; Matsui, Hidetoshi; Tanaka, Tamotsu; Matsuura, Fumito; Satouchi, Kiyoshi; Koike, Tohru

    2004-10-01

    1,2-Didocosahexaenoyl phosphatidylcholine (PC), which has highly unsaturated fatty acid at both sn-1 and sn-2 positions of glycerol, is a characteristic molecular species of bonito muscle. To examine the involvement of a de novo route in its synthesis, the molecular species of phosphatidic acid (PA) were analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using a 1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-olato dizinc(II) complex, a novel phosphate-capture molecule. However, 1,2-didocosahexaenoyl species could not be detected. Next, 1,2-didocosahexaenoyl PC synthesis by the cytosolic lysophosphatidylcholine (LPC)/transacylase was examined using endogenous LPC from bonito muscle, in which the 2-docosahexaenoyl species is abundant. The LPC/transacylase synthesized 1,2-didocosahexaenoyl PC as the most abundant molecular species. For further characterization, the LPC/transacylase was purified to homogeneity from the 100,000 x g supernatant of bonito muscle. The isolated LPC/transacylase is a labile glycoprotein with molecular mass of 52 kDa including a 5-kDa sugar moiety. The LPC/transacylase showed a PC synthesis (transacylase activity) below and above the critical micelle concentration of substrate LPC, and fatty acid release (lysophospholipase activity) was always smaller than the transacylase activity, even with a monomeric substrate. These results suggest that the LPC/transacylase is responsible for the synthesis of 1,2-didocosahexaenoyl PC.

  16. Synthesis, spectral characterization and larvicidal activity of acridin-1(2H)-one analogues

    Science.gov (United States)

    Subashini, R.; Bharathi, A.; Roopan, Selvaraj Mohana; Rajakumar, G.; Abdul Rahuman, A.; Gullanki, Pavan Kumar

    Acridin-1(2H)-one analogue of 7-chloro-3,4-dihydro-9-phenyl-2-[(pyridine-2yl) methylene] acridin-1(2H)-one, 5 was prepared by using 7-chloro-3,4-dihydro-9-phenylacridin-1(2H)-one, 3 and picolinaldehyde, 4 in the presence of KOH at room temperature. These compounds were characterized by analytical and spectral analyses. The purpose of the present study was to assess the efficacy of larvicidal and repellent activity of synthesized 7-chloro-3,4-dihydro-9-phenyl-acridin-1(2H)-one analogues such as compounds 3 and 5 against the early fourth instar larvae of filariasis vector, Culex quinquefasciatus and Japanese encephalitis vector, Culex gelidus (Diptera: Culicidae). The compound exhibited high larvicidal effects at 50 mg/L against both the mosquitoes with LC50 values of 25.02 mg/L (r2 = 0.998) and 26.40 mg/L (r2 = 0.988) against C. quinquefasciatus and C. gelidus, respectively. The 7-chloro-3,4-dihydro-9-phenyl-acridin-1(2H)-one analogues that are reported for the first time to our best of knowledge can be better explored for the control of mosquito population. This is an ideal ecofriendly approach for the control of Japanese encephalitis vectors, C. quinquefasciatus and C. gelidus.

  17. Recent Developments on 1,2,4-Triazole Nucleus in Anticancer Compounds: A Review.

    Science.gov (United States)

    Kaur, Ramandeep; Dwivedi, Ashish Ranjan; Kumar, Bhupinder; Kumar, Vinod

    2016-01-01

    1,2,4-triazole is an important nucleus present in a large number of compounds. More than thirty-five compounds containing this nucleus are introduced into the market. 1,2,4-triazole nucleus is stable to metabolism and acts as an important pharmacophore by interacting at the active site of a receptor as hydrogen bond acceptor and as a donor. Due to its polar nature, the triazole nucleus can increase the solubility of the ligand and it can significantly improve the pharmacological profile of the drug. A large number of 1,2,4-triazole derivatives are reported to possess a wide range of bioactivities including anti-cancer activity. This review article describes the role of 1,2,4-triazole nucleus in different types of anti-cancer agents such as nucleoside based anti-cancer agents, kinase inhibitors, tubulin modulators, aromatase and steroid sulfatase inhibitors, methionine aminopeptidase inhibitors, tankyrase inhibitors and metal complex based anti-cancer agents. It is expected that the current review article will provide insight into various ligand-receptor interactions and help in the rational design and development of novel 1,2,4-triazole based anti-cancer drugs with improved selectivity for cancer cells.

  18. The continuum limit of $a_{N-1}^{(2)}$ spin chains

    CERN Document Server

    Vernier, Eric; Saleur, Hubert

    2016-01-01

    Building on our previous work for $a_2^{(2)}$ and $a_3^{(2)}$ we explore systematically the continuum limit of gapless $a_{N-1}^{(2)}$ vertex models and spin chains. We find the existence of three possible regimes. Regimes I and II for $a_{2n-1}^{(2)}$ are related with $a_{2n-1}^{(2)}$ Toda, and described by $n$ compact bosons. Regime I for $a_{2n}^{(2)}$ is related with $a_{2n}^{(2)}$ Toda and involves $n$ compact bosons, while regime II is related instead with $B^{(1)}(0,n)$ super Toda, and involves in addition a single Majorana fermion. The most interesting is regime III, where {\\sl non-compact} degrees of freedom appear, generalising the emergence of the Euclidean black hole CFT in the $a_{2}^{(2)}$ case. For $a_{2n}^{(2)}$ we find a continuum limit made of $n$ compact and $n$ non-compact bosons, while for $a_{2n-1}^{(2)}$ we find $n$ compact and $n-1$ non-compact bosons. We also find deep relations between $a_{N-1}^{(2)}$ in regime III and the gauged WZW models $SO(N)/SO(N-1)$.

  19. Enzyme IIANtr Regulates Salmonella Invasion Via 1,2-Propanediol And Propionate Catabolism

    Science.gov (United States)

    Yoo, Woongjae; Kim, Dajeong; Yoon, Hyunjin; Ryu, Sangryeol

    2017-01-01

    Many Proteobacteria possess a nitrogen-metabolic phosphotransferase system (PTSNtr) consisting of EINtr, NPr, and EIIANtr (encoded by ptsP, ptsO, and ptsN, respectively). The PTSNtr plays diverse regulatory roles, but the substrate phosphorylated by EIIANtr and its primary functions have not yet been identified. To comprehensively understand the roles of PTSNtr in Salmonella Typhimurium, we compared the whole transcriptomes of wild-type and a ΔptsN mutant. Genome-wide RNA sequencing revealed that 3.5% of the annotated genes were up- or down-regulated by three-fold or more in the absence of EIIANtr. The ΔptsN mutant significantly down-regulated the expression of genes involved in vitamin B12 synthesis, 1,2-propanediol utilization, and propionate catabolism. Moreover, the invasiveness of the ΔptsN mutant increased about 5-fold when 1,2-propanediol or propionate was added, which was attributable to the increased stability of HilD, the transcriptional regulator of Salmonella pathogenicity island-1. Interestingly, an abundance of 1,2-propanediol or propionate promoted the production of EIIANtr, suggesting the possibility of a positive feedback loop between EIIANtr and two catabolic pathways. These results demonstrate that EIIANtr is a key factor for the utilization of 1,2-propanediol and propionate as carbon and energy sources, and thereby modulates the invasiveness of Salmonella via 1,2-propanediol or propionate catabolism. PMID:28333132

  20. Key role of ERK1/2 molecular scaffolds in heart pathology.

    Science.gov (United States)

    Tarone, Guido; Sbroggiò, Mauro; Brancaccio, Mara

    2013-11-01

    The ability of cardiomyocytes to detect mechanical and humoral stimuli is critical for adaptation of the myocardium in response to new conditions and for sustaining the increased workload during stress. While certain stimuli mediate a beneficial adaptation to stress conditions, others result in maladaptive remodelling, ultimately leading to heart failure. Specific signalling pathways activating either adaptive or maladaptive cardiac remodelling have been identified. Paradoxically, however, in a number of cases, the transduction pathways involved in such opposing responses engage the same signalling proteins. A notable example is the Raf-MEK1/2-ERK1/2 signalling pathway that can control both adaptive and maladaptive remodelling. ERK1/2 signalling requires a signalosome complex where a scaffold protein drives the assembly of these three kinases into a linear pathway to facilitate their sequential phosphorylation, ultimately targeting specific effector molecules. Interestingly, a number of different Raf-MEK1/2-ERK1/2 scaffold proteins have been identified, and their role in determining the adaptive or maladaptive cardiac remodelling is a promising field of investigation for the development of therapeutic strategies capable of selectively potentiating the adaptive response.

  1. Structure basis 1/2SLPI and porcine pancreas trypsin interaction

    Energy Technology Data Exchange (ETDEWEB)

    Fukushima, Kei; Kamimura, Takashi; Takimoto-Kamimura, Midori, E-mail: m.kamimura@teijin.co.jp [Teijin Institute for Bio-Medical Research, 4-3-2 Asahigaoka, Hino-shi, Tokyo 191-8512 (Japan)

    2013-11-01

    1/2SLPI is a C-terminal domain of SLPI (secretory leukocyte protease inhibitor) which inhibits various serine proteases broadly. The present study is the first X-ray structural report on how 1/2SLPI with P1 Leu strongly inhibits trypsin and how it can inhibit multiple serine proteases. SLPI (secretory leukocyte protease inhibitor) is a 107-residue protease inhibitor which inhibits various serine proteases, including elastase, cathepsin G, chymotrypsin and trypsin. SLPI is obtained as a multiple inhibitor in lung defense and in chronic airway infection. X-ray crystal structures have so far reported that they are full-length SLPIs with bovine α-chymotrypsin and 1/2SLPI (recombinant C-terminal domain of SLPI; Arg58–Ala107) with HNE (human neutrophil elastase). To understand the role of this multiple inhibitory mechanism, the crystal structure of 1/2SLPI with porcine pancreas trypsin was solved and the binding modes of two other complexes compared. The Leu residue surprisingly interacts with the S1 site of trypsin, as with chymotrypsin and elastase. The inhibitory mechanism of 1/2SLPI using the wide primary binding site contacts (from P2′ to P5) with various serine proteases is discussed. These inhibitory mechanisms have been acquired in the evolution of the protection system for acute inflammatory diseases.

  2. The ρ(ω)B*(B) interaction and states of J = 0, 1, 2

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez-Soler, P.; Sun, Zhi-Feng; Oset, E. [Centro Mixto Universidad de Valencia-CSIC Institutos de Investigacion de Paterna, Departamento de Fisica Teorica and IFIC, Valencia (Spain); Nieves, J. [Centro Mixto Universidad de Valencia-CSIC Institutos de Investigacion de Paterna, IFIC, Valencia (Spain)

    2016-02-15

    In this work, we study systems composed of a ρ/ω and B* meson pair. We find three bound states in isospin, spin-parity channels (1/2, 0{sup +}), (1/2, 1{sup +}), and (1/2, 2{sup +}). The state with J = 2 can be a good candidate for the B{sub 2}{sup *} (5747). We also study the ρB system, and a bound state with mass 5728 MeV and width around 20 MeV is obtained, which can be identified with the B1(5721) resonance. In the case of I = 3/2, one obtains repulsion and, thus, no exotic (molecular) mesons in this sector are generated in the approach. (orig.)

  3. Synthesis and anticancer activity of some 1,2,3-trisubstituted pyrazinobenzimidazole derivatives.

    Science.gov (United States)

    Demirayak, Şeref; Yurttaş, Leyla

    2014-12-01

    The synthesis of some new pyrazino[1,2-a]benzimidazole derivatives and investigation of their anticancer activities were aimed in this work. Thus, 2-acetylbenzimidazole was reacted with appropriate α-bromoacetophenones and potassium carbonate in acetone to give 2-(2-acetyl-1H-benzimidazol-1-yl)-1-phenylethanone derivatives (3a-d). These diketone compounds were reacted with varied benzylamines in acetic acid to obtain 2-benzyl-1-methylidene-3-aryl-1,2-dihydropyrazino[1,2-a]benzimidazole derivatives (4a-t). The structures of the obtained compounds were elucidated by using IR, (1)H-NMR, (13)C-NMR, MS spectral data and elemental analyses results. Anticancer activities of the selected compounds were investigated in National Cancer Institute, Bethesda, MD. 3c and 4n showed remarkable anticancer activity comparing with standard drugs, melphalan and cisplatin.

  4. Quercetin Inhibits Pulmonary Arterial Endothelial Cell Transdifferentiation Possibly by Akt and Erk1/2 Pathways

    Directory of Open Access Journals (Sweden)

    Shian Huang

    2017-01-01

    Full Text Available This study aimed to investigate the effects and mechanisms of quercetin on pulmonary arterial endothelial cell (PAEC transdifferentiation into smooth muscle-like cells. TGF-β1-induced PAEC transdifferentiation models were applied to evaluate the pharmacological actions of quercetin. PAEC proliferation was detected with CCK8 method and BurdU immunocytochemistry. Meanwhile, the identification and transdifferentiation of PAECs were determined by FVIII immunofluorescence staining and α-SMA protein expression. The related mechanism was elucidated based on the levels of Akt and Erk1/2 signal pathways. As a result, quercetin effectively inhibited the TGF-β1-induced proliferation and transdifferentiation of the PAECs and activation of Akt/Erk1/2 cascade in the cells. In conclusion, quercetin is demonstrated to be effective for pulmonary arterial hypertension (PAH probably by inhibiting endothelial transdifferentiation possibly via modulating Akt and Erk1/2 expressions.

  5. Carbohydrate-auxiliary assisted preparation of enantiopure 1,2-oxazine derivatives and aminopolyols

    Directory of Open Access Journals (Sweden)

    Marcin Jasiński

    2012-04-01

    Full Text Available An approach to enantiopure hydroxylated 2H-1,2-oxazine derivatives is presented utilizing the [3 + 3] cyclisation of lithiated alkoxyallenes and an L-erythrose-derived N-glycosyl nitrone as precursors. This key step proceeded only with moderate diastereoselectivity, but allowed entry into both enantiomeric series of the resulting 3,6-dihydro-2H-1,2-oxazines. Their enol ether double bond was then subjected to a hydroboration followed by an oxidative work-up, and finally the auxiliary was removed. The described three-step procedure enabled the synthesis of enantiopure hydroxylated 1,2-oxazines. Typical examples were treated with samarium diiodide leading to enantiopure acyclic aminopolyols. We also report on our attempts to convert these compounds into enantiopure hydroxylated pyrrolidine derivatives.

  6. A new natural naphtho[1,2-b]furan from the leaves of Cassia fistula.

    Science.gov (United States)

    Wang, Li-Qin; Tang, Zheng-Rong; Mu, Wei-Hua; Kou, Jun-Feng; He, Dong-Yang

    2013-11-01

    A new naphtho[1,2-b]furan, 2,9-dihydroxy-7-methoxy-4-methylnaphtha[1,2-b]furan-3(2H)-one (1), along with 10 known compounds vanillic acid (2), naringenin (3), glyceryl-1-tetracosanoate (4), moracin J (5), 1,3,8-trihydroxyanthraquinone (6), esculetin (7), mauritianin (8), kaempferol 3-neohesperidoside (9), β-sitosterol (10), and β-daucosterol (11), was isolated from the leaves of Cassia fistula. The structure of the new compound was determined by NMR and X-ray analysis. Compounds 1, 3, 5-9 were isolated from this plant for the first time. The naphtha[1,2-b]furan was firstly isolated from the natural resources.

  7. Anaplasma phagocytophilum AptA modulates Erk1/2 signalling.

    Science.gov (United States)

    Sukumaran, Bindu; Mastronunzio, Juliana E; Narasimhan, Sukanya; Fankhauser, Sarah; Uchil, Pradeep D; Levy, Roie; Graham, Morven; Colpitts, Tonya Michelle; Lesser, Cammie F; Fikrig, Erol

    2011-01-01

    Anaplasma phagocytophilum causes human granulocytic anaplasmosis, one of the most common tick-borne diseases in North America. This unusual obligate intracellular pathogen selectively persists within polymorphonuclear leucocytes. In this study, using the yeast surrogate model we identified an A. phagocytophilum virulence protein, AptA (A. phagocytophilum toxin A), that activates mammalian Erk1/2 mitogen-activated protein kinase. This activation is important for A. phagocytophilum survival within human neutrophils. AptA interacts with the intermediate filament protein vimentin, which is essential for A. phagocytophilum-induced Erk1/2 activation and infection. A. phagocytophilum infection reorganizes vimentin around the bacterial inclusion, thereby contributing to intracellular survival. These observations reveal a major role for the bacterial protein, AptA, and the host protein, vimentin, in the activation of Erk1/2 during A. phagocytophilum infection.

  8. Cordyceps bassiana inhibits smooth muscle cell proliferation via the ERK1/2 MAPK signaling pathway.

    Science.gov (United States)

    Jin, Enze; Han, Seongho; Son, Mina; Kim, Sung-Whan

    2016-01-01

    Cordyceps belongs to a genus of acormycete fungi and is known to exhibit various pharmacological effects. The aim of this study was to investigate the effect of Cordyceps species on the proliferation of vascular smooth muscle cells (VSMC) and their underlying molecular mechanism. A cell proliferation assay showed that Cordyceps bassiana ethanol extract (CBEE) significantly inhibited VSMC proliferation. In addition, neointimal formation was significantly reduced by treatment with CBEE in the carotid artery of balloon-injured rats. We also investigated the effects of CBEE on the extracellular signal-regulated kinase (ERK) signal pathway. Western blot analysis revealed increased ERK 1/2 phosphorylation in VSMCs treated with CBEE. Pretreatment with U0126 completely abrogated CBEE-induced ERK 1/2 phosphorylation. In conclusion, CBEE exhibited anti-proliferative properties that affected VSMCs through the ERK1/2 MAPK signaling pathway. Our data may elucidate the inhibitory mechanism of this natural product.

  9. The antimicrobial peptide aurein 1.2 disrupts model membranes via the carpet mechanism.

    Science.gov (United States)

    Fernandez, David I; Le Brun, Anton P; Whitwell, Thomas C; Sani, Marc-Antoine; James, Michael; Separovic, Frances

    2012-12-05

    The membrane interactions of the antimicrobial peptide aurein 1.2 were studied using a range of biophysical techniques to determine the location and the mechanism of action in DMPC (dimyristoylphosphatidylcholine) and DMPC/DMPG (dimyristoylphosphatidylglycerol) model membranes that mimic characteristics of eukaryotic and prokaryotic membranes, respectively. Neutron reflectometry and solid-state NMR revealed subtle changes in membrane structure caused by the peptide. Quartz crystal microbalance with dissipation, vesicle dye leakage and atomic force microscopy measurements were used to investigate the global mode of peptide interaction. Aurein 1.2 displayed an enhanced interaction with the anionic DMPC/DMPG membrane while exhibiting primarily a surface interaction with both types of model membranes, which led to bilayer disruption and membrane lysis. The antimicrobial peptide interaction is consistent with the carpet mechanism for aurein 1.2 with discrete structural changes depending on the type of phospholipid membrane.

  10. Blocking Effect and Moments of Inertia of K = 1/2 Rotational Band in 171Yb

    Institute of Scientific and Technical Information of China (English)

    YU Shao-Ying; LIU Yan-Xin; LIU Shu-Xin; HE Xiao-Tao

    2004-01-01

    The K = 1/2 rotational band in 171yb is investigated using the particle number conserving (PNC) method for treating the cranked shell model with monopole and quadrupole pairing interactions. The experimental moments of inertia of 171 Yb [521]1/2 (signature α = +1/2) are reproduced well by the PNC calculation, in which no free parameter is involved. The difference in the contribution to the moment of inertia between protons and neutrons is mainly due to the blocking effect of neutron normal orbitals. The ω variation of the occupation probability of each cranked orbital and the contribution to the moment of inertia from each major shell and from each cranked orbital are investigated.

  11. JMJD-1.2/PHF8 controls axon guidance by regulating Hedgehog-like signaling

    DEFF Research Database (Denmark)

    Riveiro, Alba; Mariani, Luca; Malmberg, Kim Emily

    2017-01-01

    Components of the KDM7 family of histone demethylases are implicated in neuronal development and one member, PHF8, is often found to be mutated in cases of X-linked mental retardation. However, how PHF8 regulates neurodevelopmental processes and contributes to the disease is still largely unknown...... study highlights a novel function of jmjd-1.2 in axon guidance that might be relevant for the onset of X-linked mental retardation and provides compelling evidence of a conserved function of the Hedgehog pathway in C. elegans axon migration........ Here, we show that the catalytic activity of a PHF8 homolog in Caenorhabditis elegans, JMJD-1.2, is required non-cell-autonomously for proper axon guidance. Loss of JMJD-1.2 dysregulates transcription of the Hedgehog-related genes wrt-8 and grl-16, the overexpression of which is sufficient to induce...

  12. Biodegradation of p-nitrophenol via 1,2,4-benzenetriol by an Arthrobacter sp.

    Energy Technology Data Exchange (ETDEWEB)

    Jain, R.K.; Spain, J.C. [Armstrong Lab., Tyndall Air Force Base, FL (United States); Dreisbach, J.H. [Univ. of Scranton, PA (United States)

    1994-08-01

    The degradation of p-nitrophenol (PNP) by Moraxella and Pseudomonas spp. involves an initial monooxygenase-catalyzed removal of the nitro group. The resultant hydroquinone is subject to ring fission catalyzed by a dioxygenase enzyme. A strain of an Arthrobacter sp. JS443, capable of degrading PNP with stoichiometric release of nitrite has been isolated. During induction of the enzymes required for growth on PNP, 1,2,4-benzenetriol was identified as an intermediate by gas chromatography-mass spectroscopy and radiotracer studies. 1,2,4-Benzenetriol was converted to maleylacetic acid, which was further degraded by the beta-ketoadipate pathway. Conversion of PNP to 1,2,4-benzenetriol is catalyzed by a monooxygenase system in strain JS443 through the formation of 4-nitrocatechol, 4-nitroresorcinol, or both. Results clearly indicate the existence of an alternative pathway for the biodegradation of PNP. 15 refs, 2 figs., 2 tabs.

  13. Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups.

    Science.gov (United States)

    Soeda, Yoshiyuki; Yoshikawa, Misato; Almeida, Osborne F X; Sumioka, Akio; Maeda, Sumihiro; Osada, Hiroyuki; Kondoh, Yasumitsu; Saito, Akiko; Miyasaka, Tomohiro; Kimura, Tetsuya; Suzuki, Masaaki; Koyama, Hiroko; Yoshiike, Yuji; Sugimoto, Hachiro; Ihara, Yasuo; Takashima, Akihiko

    2015-12-16

    Neurofibrillary tangles, composed of hyperphosphorylated tau fibrils, are a pathological hallmark of Alzheimer's disease; the neurofibrillary tangle load correlates strongly with clinical progression of the disease. A growing body of evidence indicates that tau oligomer formation precedes the appearance of neurofibrillary tangles and contributes to neuronal loss. Here we show that tau oligomer formation can be inhibited by compounds whose chemical backbone includes 1,2-dihydroxybenzene. Specifically, we demonstrate that 1,2-dihydroxybenzene-containing compounds bind to and cap cysteine residues of tau and prevent its aggregation by hindering interactions between tau molecules. Further, we show that orally administered DL-isoproterenol, an adrenergic receptor agonist whose skeleton includes 1,2-dihydroxybenzene and which penetrates the brain, reduces the levels of detergent-insoluble tau, neuronal loss and reverses neurofibrillary tangle-associated brain dysfunction. Thus, compounds that target the cysteine residues of tau may prove useful in halting the progression of Alzheimer's disease and other tauopathies.

  14. Predicted Higgs-related spin 1/2 particles as a new dark matter candidate

    CERN Document Server

    Stenzel, Joshua; Lei, Minjie; Allen, Roland E

    2015-01-01

    The theory at arXiv:1101.0586 [hep-th] predicts new fundamental spin $1/2$ particles which can be produced in pairs through their couplings to vector bosons or fermions. The lowest-energy of these should have a mass $m_{1/2}$ comparable to the mass $m_h$ of the recently discovered Higgs boson, with $m_{1/2} = m_h$ in the simplest model. These particles should therefore be detectable in collider experiments, perhaps in Run 2 or 3 of the LHC. They cannot decay through any obvious mechanisms in standard physics, making them a new dark matter candidate. In the simplest model, annihilations would produce a well-defined signature with photons, positrons, and excess electrons at about 125 GeV, and the mass would also be well-defined for direct dark matter detection.

  15. A NEW POLYMER-BOUND 1,2-DIOL AS A PROTECTING AGENT FOR SYMMETRICAL DIALDEHYDE

    Institute of Scientific and Technical Information of China (English)

    REN Qisheng; HUANG Wenqiang; ZHAO Fengzhi; Ho Binglin

    1989-01-01

    A novel polymer- bound 1,2 - diol, 3 - polystyrylsulfonyl- 1,2 - propanediol (6) had ben prepared by the reaction of sodium polystyrylsulfinate with allyl bromide, followed by oxidation and. hydrolysis or directly with 3 - chloro - 1,2 - propanediol in the presence of a phase transfer catalyst ,n - tetrabutylammonium iodide. The capacity of resin 6 for terephthaldehyde reached 1.43 mmol/g. The aldehydic groups attached to polymer 6 reacted with hydroxylamine hydrochloride or reduced by sodium borohydride giving p-formylbenzaldoxime (yield:89%)and p-formyl -benzalcohol (yield:73 A % ), respectively. The high yields of these polymer-supported reactions showed that the polymer 6 possessed the effective isolation of its reactive sites.

  16. N-Carbethoxy-N′-(3-phenyl-1H-1,2,4-triazol-5-ylthiourea

    Directory of Open Access Journals (Sweden)

    Anton V. Dolzhenko

    2010-02-01

    Full Text Available The title compound {systematic name: ethyl N-[N-(3-phenyl-1H-1,2,4-triazol-5-ylcarbamothioyl]carbamate}, C12H13N5O2S, exists in the 3-phenyl-5-thioureido-1H-1,2,4-triazole tautomeric form stabilized by intramolecular hydrogen bonding between the endocyclic NH H atom and the thioureido S atom. The molecular structure is also stabilized by intramolecular N—H...O=C hydrogen bonds arranged in an S(6 graph-set motif within the carbethoxythiourea moiety. The mean planes of the phenyl and 1,2,4-triazole rings make a dihedral angle of 7.61 (11°. In the crystal, the molecules form two types of inversion dimers. Intermolecular hydrogen bonds are arranged in R22(6 and R22(8 graph-set motifs, together forming a network parallel to (111.

  17. BRCA 1/2-mutation related and sporadic breast and ovarian cancers: More alike than different

    Directory of Open Access Journals (Sweden)

    Melissa A. Burgess

    2014-02-01

    Full Text Available No longer is histology solely predictive of cancer treatment and outcome. There is an increasing influence of tumor genomic characteristics on therapeutic options. Both breast and ovarian cancers are at higher risk of development in patients with BRCA 1/2-germline mutations. Recent data from the Cancer Genome Atlas (TCGA and others have shown a number of genomic similarities between triple negative breast cancers and ovarian cancers. Recently, poly (ADP-ribose polymerase (PARP inhibitors have shown promising activity in hereditary BRCA 1/2-mutated and sporadic breast and ovarian cancers. In this review, we will summarize the current literature regarding the genomic and phenotypic similarities between BRCA 1/2-mutation related cancers, sporadic triple negative breast cancers, and sporadic ovarian cancers. We will also review phase I, II, and III data using PARP inhibitors for these malignancies and compare and contrast the results with respect to histology.

  18. Engineering a catabolic pathway in plants for the degradation of 1,2-dichloroethane.

    Science.gov (United States)

    Mena-Benitez, Gilda L; Gandia-Herrero, Fernando; Graham, Stuart; Larson, Tony R; McQueen-Mason, Simon J; French, Christopher E; Rylott, Elizabeth L; Bruce, Neil C

    2008-07-01

    Plants are increasingly being employed to clean up environmental pollutants such as heavy metals; however, a major limitation of phytoremediation is the inability of plants to mineralize most organic pollutants. A key component of organic pollutants is halogenated aliphatic compounds that include 1,2-dichloroethane (1,2-DCA). Although plants lack the enzymatic activity required to metabolize this compound, two bacterial enzymes, haloalkane dehalogenase (DhlA) and haloacid dehalogenase (DhlB) from the bacterium Xanthobacter autotrophicus GJ10, have the ability to dehalogenate a range of halogenated aliphatics, including 1,2-DCA. We have engineered the dhlA and dhlB genes into tobacco (Nicotiana tabacum 'Xanthi') plants and used 1,2-DCA as a model substrate to demonstrate the ability of the transgenic tobacco to remediate a range of halogenated, aliphatic hydrocarbons. DhlA converts 1,2-DCA to 2-chloroethanol, which is then metabolized to the phytotoxic 2-chloroacetaldehyde, then chloroacetic acid, by endogenous plant alcohol dehydrogenase and aldehyde dehydrogenase activities, respectively. Chloroacetic acid is dehalogenated by DhlB to produce the glyoxylate cycle intermediate glycolate. Plants expressing only DhlA produced phytotoxic levels of chlorinated intermediates and died, while plants expressing DhlA together with DhlB thrived at levels of 1,2-DCA that were toxic to DhlA-expressing plants. This represents a significant advance in the development of a low-cost phytoremediation approach toward the clean-up of halogenated organic pollutants from contaminated soil and groundwater.

  19. Specific monoclonal antibodies against IDH1/2 mutations as diagnostic tools for gliomas.

    Science.gov (United States)

    Kato, Yukinari

    2015-01-01

    Mutations of isocitrate dehydrogenase 1/2 (IDH1/2) have been reported in gliomas and other types of tumors, such as acute myeloid leukemias, cartilaginous tumors, intrahepatic cholangiocarcinomas, osteosarcomas, and giant cell tumors of bone. In gliomas, IDH mutations uniformly occur in the functionally critical arginine 132 residue (R132) of IDH1 and arginine 172 residue (R172) of IDH2. IDH1 and IDH2 catalyze the oxidative carboxylation of isocitrate to α-ketoglutarate (α-KG) in the cytosol and mitochondria, respectively. In contrast, mutated IDH1/2 proteins possess a neomorphic enzymatic function that changes α-KG into the oncometabolite, R(-)-2-hydroxyglutarate, resulting in genomic hypermethylation, histone methylation, genetic instability, and malignant transformation. To date, several monoclonal antibodies (mAbs) specific for IDH1/2 mutations such as anti-IDH1-R132H mAbs (clone H09, clone IMab-1, and clone HMab-1) or an anti-IDH1-R132S mAb (clone SMab-1) have been established. Furthermore, one of multi-specific mAbs, MsMab-1, recognizes IDH1 mutants (R132H, R132S, R132G) and IDH2 mutants (R172S, R172G), which are observed in gliomas. Another mAb, MsMab-2, recognizes IDH1-R132L and IDH2-R172M. These IDH1/2 mutation-specific mAbs are useful for the immunohistochemical determination of IDH1/2 mutation-bearing gliomas.

  20. Phototoxicity and chronic toxicity of methyl paraben and 1,2-hexanediol in Daphnia magna.

    Science.gov (United States)

    Lee, Jiyun; Park, Nayeon; Kho, Younglim; Lee, Kiyoung; Ji, Kyunghee

    2017-01-01

    Parabens are used as antimicrobial preservatives in consumer products. Exposure to methylparaben (MP) has been associated with adverse health outcomes, therefore, an alternative compound, 1,2-hexanediol (1,2-H), has been applied for cosmetics. In the present study, the phototoxicity of MP and 1,2-H, as well as the toxic effect caused by chronic exposure, were investigated using Daphnia magna. The 48 h acute toxicity tests with D. magna were conducted under indoor or ultraviolet (UV) light irradiation conditions, i.e., exposure to 4 h/d sunlight. Changes in the transcription of genes related to oxidative stress were determined in D. magna juveniles, to investigate the underlying mechanism of phototoxicity. The 21 d chronic toxicity tests of MP and 1,2-H were performed under indoor light irradiation. Exposure to MP under environmental level of UV light was more detrimental to D. magna. Transcripts of catalase and glutathione-S-transferase genes in D. magna was significantly increased by co-exposure to MP and UV light. After 21 d of chronic exposure to MP and 1,2-H, the reproduction no-observed effect concentrations for D. magna were 1 and >10 mg/L, respectively. The present study showed that exposure to UV could magnify the toxicity of MP on daphnids. Although acute and chronic toxicities of 1,2-H were generally lower than those of MP, its effects on other aquatic organisms should not be ignored. Further studies are needed to identify other mechanisms of MP phototoxicity.