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Sample records for na retinosquise senil

  1. Retinosquises

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    Manuel A P Vilela

    2011-04-01

    Full Text Available Retinosquise traduz a separação anômala das camadas retinianas, podendo ser congênita, adquirida ou secundária a situações como a miopia, trauma e vasculopatias. Reúne-se as principais características clínicas, recentes opções diagnósticas e as formas de manejo dos quadros ligados ao cromossoma X e aos adquiridos.

  2. The senile kidney

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    Denisova Т.Р.

    2015-03-01

    Full Text Available The given work summarizes external data and self-obtained results on development and diagnostic of kidney involution modifications. Article discusses definition of "senile kidney" as a clinical and pathomorphological term. Major statements on pathophysiological causes of age-associated renal disorders and their prognosis, specifics of chronic kidney disease in elderly and senile patients have been reviewed. Phenomenon of renal "multimorbidity" in eldely maximizes worsening risk of unmodifiable kidney function.

  3. Occurrence of silent cerebral infarction in pre-senile, senile subjects with depressive states

    International Nuclear Information System (INIS)

    Fujikawa, Tokumi; Yamawaki, Shigeto; Touhouda, Yoshikuni.

    1993-01-01

    We examined the relationship between pre-senile, senile depressive states and silent cerebral infarction (SCI) using magnetic resonance imaging (MRI). The diagnostic criteria of major depression according to DSM-3-R was used to diagnose. Patients in whom stroke had occurred or who had local neurologic symptoms were not included. About half of the patients with depressive states of pre-senile onset and most of the patients with those of senile onset had SCI, were considered to be organic-depressive states complicated with SCI. Because patients with depressive states with SCI are at high risk of occurrence of stroke, we designated this condition 'pre-stroke depression', and classified it with endogenous depression. At this time, it is important to begin therapy for cerebrovascular disease. (author)

  4. Acid rain may cause senile dementia

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    Pearce, F

    1985-04-25

    Aluminium, released from the soil by acid rain, may be a cause of several forms of senile dementia including Parkinson's disease and Alzheimer's disease. Many upland reservoirs, fed by acid rain, supply homes with water laced with significant amounts of aluminium. Studies in the Pacific have shown that communities living on soils that are extremely rich in bauxite, the rock containing aluminium, have a very high incidence of Alzheimer's disease.

  5. Clinical study of correlation of pre-senile and senile depressive stage with silent cerebral infarction

    International Nuclear Information System (INIS)

    Fujikawa, Tokumi; Yamawaki, Shigeto; Fujita, Yasunobu; Shibata, Youko; Touhouda, Yoshikuni.

    1992-01-01

    The relationship between the pre-senile/senile depressive state and silent cerebral infarction was examined by MRI. Consecutive 56 depressive patients aged 50 years or older underwnt MRI. MRI revealed silent cerebral infarction in 60.3% of patients in whom depression occurred at the age of less than 65 years. The complication rate was significantly higher in these patients than the younger patients (60.9% vs 20%). Complications of silent cerebral infarction were found in 53.6% for patients in whom depression occurred at the age of less than 65 years and symptoms were deteriorated at the age of 65 years or older and in 100% for patients in whom it occurred at the age of 65 years or older and hospitalization was simultaneously required. These figures were remarkably higher than the age-related complication rate of silent cerebral infarction in non-depressive normal persons. This suggested that approximately half of depressive patients of pre-senile onset and majority of depressive patients of senile onset might have parenchymal involvement due to silent cerebral infarction. Both perforating-type and cortical-type infarcts were found. This has a implication for the involvement of multiple infarct-related foci in depressive state. For cortical-type infarcts, partial lesions were predominant, followed by frontal and temporal lesions. The incidence of left frontal infarcts was significanly higher than that of right frontal infarcts. Infarcts in both the parietal and left frontal lobes may be responsible for depressive state. (N.K.)

  6. Differential alterations of cortical glutamatergic binding sites in senile dementia of the Alzheimer type

    International Nuclear Information System (INIS)

    Chalmers, D.T.; Dewar, D.; Graham, D.I.; Brooks, D.N.; McCulloch, J.

    1990-01-01

    Involvement of cortical glutamatergic mechanisms in senile dementia of the Alzheimer type (SDAT) has been investigated with quantitative ligand-binding autoradiography. The distribution and density of Na(+)-dependent glutamate uptake sites and glutamate receptor subtypes--kainate, quisqualate, and N-methyl-D-aspartate--were measured in adjacent sections of frontal cortex obtained postmortem from six patients with SDAT and six age-matched controls. The number of senile plaques was determined in the same brain region. Binding of D-[3H]aspartate to Na(+)-dependent uptake sites was reduced by approximately 40% throughout SDAT frontal cortex relative to controls, indicating a general loss of glutamatergic presynaptic terminals. [3H]Kainate receptor binding was significantly increased by approximately 70% in deep layers of SDAT frontal cortex compared with controls, whereas this binding was unaltered in superficial laminae. There was a positive correlation (r = 0.914) between kainate binding and senile plaque number in deep cortical layers. Quisqualate receptors, as assessed by 2-amino-3-hydroxy-5-[3H]methylisoxazole-4-propionic acid binding, were unaltered in SDAT frontal cortex compared with controls. There was a small reduction (25%) in N-methyl-D-aspartate-sensitive [3H]glutamate binding only in superficial cortical layers of SDAT brains relative to control subjects. [3H]Glutamate binding in SDAT subjects was unrelated to senile plaque number in superficial cortical layers (r = 0.104). These results indicate that in the presence of cortical glutamatergic terminal loss in SDAT plastic alterations occur in some glutamate receptor subtypes but not in others

  7. Senile Dementia from Neuroscientific and Islamic Perspectives.

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    Tumiran, Mohd Amzari; Abdul Rahman, Noor Naemah; Mohd Saat, Rohaida; Ismail, Ahmad Zuhdi; Ruzali, Wan Adriyani Wan; Bashar, Nurul Kabir Nurul; Hasan Adli, Durriyyah Sharifah

    2018-02-01

    Diseases involving the nervous system drastically change lives of victims and commonly increase dependency on others. This paper focuses on senile dementia from both the neuroscientific and Islamic perspectives, with special emphasis on the integration of ideas between the two different disciplines. This would enable effective implementation of strategies to address issues involving this disease across different cultures, especially among the world-wide Muslim communities. In addition, certain incongruence ideas on similar issues can be understood better. The former perspective is molded according to conventional modern science, while the latter on the analysis of various texts including the holy Qur'an, sunnah [sayings and actions of the Islamic prophet, Muhammad (pbuh)] and writings of Islamic scholars. Emphasis is particularly given on causes, symptoms, treatments and prevention of dementia.

  8. Occurrence of silent cerebral infarction in pre-senile, senile subjects with depressive states; MRI findings and its distribution

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    Fujikawa, Tokumi; Yamawaki, Shigeto (Hiroshima Univ. (Japan). School of Medicine); Touhouda, Yoshikuni

    1993-02-01

    We examined the relationship between pre-senile, senile depressive states and silent cerebral infarction (SCI) using magnetic resonance imaging (MRI). The diagnostic criteria of major depression according to DSM-3-R was used to diagnose. Patients in whom stroke had occurred or who had local neurologic symptoms were not included. About half of the patients with depressive states of pre-senile onset and most of the patients with those of senile onset had SCI, were considered to be organic-depressive states complicated with SCI. Because patients with depressive states with SCI are at high risk of occurrence of stroke, we designated this condition 'pre-stroke depression', and classified it with endogenous depression. At this time, it is important to begin therapy for cerebrovascular disease. (author).

  9. Computed tomography in presenile, senile dementia

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    Tanabe, N [Jikei Univ., Tokyo (Japan). School of Medicine

    1981-05-01

    The author investigated the relations of brain atrophy demonstrated by computerized tomography, dementia and electroencephalogram (EEG) in presenile and senile diseases. The result revealed that the correlation of brain atrophy, when demonstrated on the basis of ventricular ratio, is more definite and higher with dementia than that when demonstrated on the ventricular width. It was also revealed that in the control group, the ventricle gets enlarged due to aging, but no such tendency was observed in the patient group. In the case of septugenarians, no significant difference was observed between the two, and the ventricular-brain ratio or the criteria of brain atrophy is 8 -- 9% in patients in their forties to fifties; 12% for those in their sixties, and more than 15% among those in their seventies. In the relation of the brain atrophy to EEG, it was revealed that EEG is closely related to dementia than is the ventricular ratio. Upon following the progress of patients with Alzheimer, it was found that dementia and brain atrophy do not progress parallel to each other, but in stages.

  10. Computed tomography in presenile, senile dementia

    International Nuclear Information System (INIS)

    Tanabe, Norimitsu

    1981-01-01

    The author investigated the relations of brain atrophy demonstrated by computerized tomography, dementia and electroencephalogram (EEG) in presenile and senile diseases. The result revealed that the correlation of brain atrophy, when demonstrated on the basis of ventricular ratio, is more definite and higher with dementia than that when demonstrated on the ventricular width. It was also revealed that in the control group, the ventricle gets enlarged due to aging, but no such tendency was observed in the patient group. In the case of septugenarians, no significant difference was observed between the two, and the ventricular-brain ratio or the criteria of brain atrophy is 8 -- 9% in patients in their forties to fifties; 12% for those in their sixties, and more than 15% among those in their seventies. In the relation of the brain atrophy to EEG, it was revealed that EEG is closely related to dementia than is the ventricular ratio. Upon following the progress of patients with Alzheimer, it was found that dementia and brain atrophy do not progress parallel to each other, but in stages. (author)

  11. Traditional Chinese Medicine for Senile Dementia

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    Zhihong Lin

    2012-01-01

    Full Text Available Traditional Chinese Medicine (TCM has a 3000 years' history of human use. A literature survey addressing traditional evidence from human studies was done, with key result that top 10 TCM herb ingredients including Poria cocos, Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae were prioritized for highest potential benefit to dementia intervention, related to the highest frequency of use in 236 formulae collected from 29 ancient Pharmacopoeias, ancient formula books, or historical archives on ancient renowned TCM doctors, over the past 10 centuries. Based on the history of use, there was strong clinical support that Radix polygalae is memory improving. Pharmacological investigation also indicated that all the five ingredients mentioned above can elicit memory-improving effects in vivo and in vitro via multiple mechanisms of action, covering estrogen-like, cholinergic, antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities. Furthermore, 11 active principles were identified, including sinapic acid, tenuifolin, isoliquiritigenin, liquiritigenin, glabridin, ferulic acid, Z-ligustilide, N-methyl-beta-carboline-3-carboxamide, coniferyl ferulate and 11-angeloylsenkyunolide F, and catalpol. It can be concluded that TCM has a potential for complementary and alternative role in treating senile dementia. The scientific evidence is being continuously mined to back up the traditional medical wisdom.

  12. Hypothalamic digoxin and hemispheric chemical dominance--relation to the pathogenesis of senile osteoporosis, degenerative osteoarthritis, and spondylosis.

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    Kurup, Ravi Kumar; Kurup, Parameswara Achutha

    2003-03-01

    The isoprenoid pathway produces three key metabolites: i) digoxin (a membrane sodium-potassium ATPase inhibitor which can regulate intracellular calcium/magnesium ratios), ii) dolichol (which regulates N-glycosylation of proteins), and iii) ubiquinone (a free radical scavenger), all of which are important in bone and joint metabolism. The pathway was assessed in senile osteoporosis, spondylosis, and osteoarthritis. Digoxin could possibly play a role in the genesis of cerebral dominance because it can regulate multiple neurotransmitter systems. The pathway was also assessed in individuals of differing hemispheric dominance for comparison and to find out the role of cerebral dominance in the pathogenesis of these diseases. The plasma/serum-activity of HMG CoA reductase, magnesium, digoxin, dolichol, ubiquinone, and tryptophan/tyrosine catabolic patterns, as well as RBC Na(+)-K+ ATPase activity, were measured in the above mentioned groups. The glycoconjugate metabolism, free radical metabolism, and membrane composition were also studied. The pathway was upregulated with increased digoxin synthesis in patients with spondylosis and osteoarthritis. In this group of patients, the glycoconjugate levels and dolichol levels were increased and lysosomal stability reduced. The ubiquinone levels were low and free radicals increased in spondylosis and osteoarthritis. On the other hand, in senile osteoporosis, the isoprenoid pathway was downregulated and digoxin synthesis reduced. The glycoconjugate and dolichol levels were low and lysosomal stability increased. The ubiquinone levels were increased and free radical production increased in senile osteoporosis. The significance of these changes in the pathogenesis of osteoarthritis, spondylosis, and osteoporosis is discussed. The hyperdigoxinemic state is seen in osteoarthritis and spondylosis and in right hemispheric dominance. The hypodigoxinemic state is seen in left hemispheric dominance and senile osteoporosis. Hemispheric

  13. Computed tomography in patients with senile mental disorders

    International Nuclear Information System (INIS)

    Sugai, Yuuichi; Nakayama, Hirosi; Tatemichi, Nobuhiro

    1987-01-01

    Computed tomography (CT) was employed to follow up 28 patients with senile mental disorders (52 to 84 years of age) over a period of one to six and a half years after the first presentation. The first CT scans showed ventricular enlargement in many instances, which made it difficult to distinguish functional from degenerative diseases. The yearly rate of ventricular enlargement was, therefore, obtained on sequential CT scannings. The yearly rate of ventricular enlargement was high, which was associated with progression of the disease in the group with Alzheimer's disease. In the group with functional diseases, however, ventricular enlargement and progression were independent of each other. Both the yearly rate of ventricular enlargement and mental function significantly correlated with decreased adaptation of daily life. Periodical CT scanning and clinical observation over a certain period may offer useful information on the differential diagnosis and prognosis of senile mental disorders. (Namekawa, K.)

  14. Operational criteria for senile dementia of Lewy body type (SDLT).

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    McKeith, I G; Perry, R H; Fairbairn, A F; Jabeen, S; Perry, E K

    1992-11-01

    Recent reports have suggested that brain stem and cortical Lewy body formation may identify a neurodegenerative disorder in elderly demented individuals which accounts for up to 20% of cases of senile dementia coming to autopsy. Retrospective analysis of case notes of 21 autopsy patients with neuropathologically proven senile dementia of Lewy body type (SDLT) and 37 cases with neuropathologically proven Alzheimer's disease (AD) identified a characteristic clinical syndrome in SDLT. Fluctuating cognitive impairment; psychotic features including visual and auditory hallucinations, and paranoid delusions; depressive symptoms; falling and unexplained losses of consciousness were all seen significantly more often than in AD. Over half of the SDLT patients in this series who were given neuroleptics in standard dose showed acute and often irreversible adverse reactions indicative of a neuroleptic sensitivity syndrome. The survival time of drug treated patients was reduced by 50%. Operational criteria to aid in the clinical distinction between SDLT and AD patients are proposed and hypotheses regarding possible aetiology and treatment discussed.

  15. Computerized tomography of the brain in senile depression

    International Nuclear Information System (INIS)

    Yoshimura, Yoshitaka

    1995-01-01

    Brain CT was performed on 33 senile depression patients. Sixteen healthy volunteers served as controls. The correlation between changes of brain CT findings and mental symtoms was also studied. The CT findings were assessed by visual, linear, and two-dimensional methods, and mental symptoms were assessed according to Hamilton's Psychiatric Rating Scale for Depression. Arophic changes were observed in the bilateral frontal lobe and left basal ganglia areas. The correlation between severity of atrophy and mental symptom profile of depression was suggested. Depression patients, especially with marked atrophy in the frontal lobe, were prone to be indifferent to their job and hobby, to depress psychomotor, and to show marked physical symptoms. The atrophic sites observed in depression patients were also common in dementia, suggesting the correlation between senile depression and dementia. (S.Y.)

  16. The Anesthetic Effect of Dexmedetomidine on ERCP of Senile Patients

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    Liang Feng

    2017-01-01

    Full Text Available Objective: to discuss the effectiveness and security of Dexmedetomidine’s conscious-sedation application in ERCP of senile patients. Method: selecting 80 senile patients performed with ERCP and randomly dividing them into Dexmedetomidine group (group D and normal saline group (group C with 40 cases in each group. Pumping 0.5 ~ 0.8 ug/kg Dexmedetomidine through the vein 15 min after surgery while pumping isodose NS to group C at the same time. Results: both the two groups completed the ERCP treatment. The tolerance of group C is poorer with more adverse reactions; the operating time of group D is shorter, but the difference has no statistical significance. During the operation, compared with group D, the MBP and HR value of group C rose obviously with significant difference (P < 0.05 while the MBP has no obvious change within the group; HR declined sharply after pump injection (P < 0.05, but the value is within the normal range. The contrast of SPO2 and RR within and between the two groups have no significant difference. Conclusion: applying Dexmedetomidine for conscioussedation in senile patients’ ERCP leads to hemodynamic stability and no respiratory depression with less adverse reactions. The application during the perioperative period is effective, safe and comfortable, worthy of popularization and application in clinic.

  17. Risk factors which cause senile cataract evolvement: outline

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    E.V. Bragin

    2018-03-01

    Full Text Available Examination of natural ageing processes including those caused by multiple external factors has been attracting re-searchers' attention over the last years. Senile cataract is a multi-factor disease. Expenditure on cataract surgery remain one of the greatest expenses items in public health care. Age is a basic factor which causes senile cataract. Morbidity with cataract doubles each 10 years of life. This outline considers some literature sources which describe research results on influence exerted on cataract evolvement by such risk factors as age, sex, race, smoking, alcohol intake, pancreatic diabetes, intake of certain medications, a number of environmental factors including ultraviolet and ionizing radiation. mane of these factors are shown to increase or reduce senile cataract risk; there are conflicting data on certain factors. The outline also contains quantitative characteristics of cataract risks which are given via odds relation and evolve due to age parameters impacts, alcohol intake, ionizing radiation, etc. The authors also state that still there is no answer to the question whether dose-effect relationship for cataract evolvement is a threshold or non-threshold.

  18. Identification and analysis of senile plaques using nuclear microscopy

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    Landsberg, J P; Roberts, J M; Grime, G W; Watt, F [Nuclear Physics Lab., Oxford (UK); McDonald, B [Dept. of Neuropathology, Radcliffe Infirmary, Oxford (UK) Nuffield Dept. of Pathology, John Radcliffe Hospital, Oxford (UK) MRC Neuroanatomical Unit, Dept. of Pharmacology, Oxford (UK)

    1991-03-01

    The senile plaques and neuro-fibrillary tangles which form part of the pathology of Alzheimer's disease have come under increasing scrutiny over the last decade. In particular, much work has been done investigating their elemental composition. The suggestion that 75-100% of tensile plaques with mature cores contain aluminium and silicon, probably in the form of alumino-silicates, has led to increasing speculation about the role of these elements in the disease. SPM preliminary studies suggest that aluminium and silicon are not present in as great a proportion of senile plaques as presented in the literature. The situation is complicated by the fact that airborn and solubilised salts of aluminium and silicon may be encountered as contamination. They have been found, for example, in granular or crystalline form in the Aristar grade organic laboratory reagents used for staining the tissue, and in the pure pioloform used to back the samples. The latest results from scans of stained and unstained Alzheimer tissue are presented. (orig.).

  19. Identification and analysis of senile plaques using nuclear microscopy

    International Nuclear Information System (INIS)

    Landsberg, J.P.; Roberts, J.M.; Grime, G.W.; Watt, F.; McDonald, B.

    1991-01-01

    The senile plaques and neuro-fibrillary tangles which form part of the pathology of Alzheimer's disease have come under increasing scrutiny over the last decade. In particular, much work has been done investigating their elemental composition. The suggestion that 75-100% of tensile plaques with mature cores contain aluminium and silicon, probably in the form of alumino-silicates, has led to increasing speculation about the role of these elements in the disease. SPM preliminary studies suggest that aluminium and silicon are not present in as great a proportion of senile plaques as presented in the literature. The situation is complicated by the fact that airborn and solubilised salts of aluminium and silicon may be encountered as contamination. They have been found, for example, in granular or crystalline form in the Aristar grade organic laboratory reagents used for staining the tissue, and in the pure pioloform used to back the samples. The latest results from scans of stained and unstained Alzheimer tissue are presented. (orig.)

  20. Cataratas senil bilateral psicológico pre y posoperatorio Bilateral senile cataract: a pre- and postoperavitve psychological study

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    Armando Rodríguez Romero

    2003-12-01

    Full Text Available Se realizó un estudio psicológico comparativo en 50 pacientes con catarata senil bilateral antes y después de la operación, en el período comprendido de enero a diciembre de1999 según las variables de edad, escolaridad y estado civil. Predominó el grupo etáreo de 70 a 79 años, nivel escolar primario y estado civil casado. Los síntomas psicopatológicos y la distribución según trastornos psiquiátricos disminuyeron después de restablecida su visión una vez operados de cataratas, en los de ansiedad y tristeza de 42 a7 pacientes respectivamente.A psychological comparative study was conducted among 50 patients with senile bilareral cataract before and after the operation from January to December, 1999, according to the following variables: age, educational level and marital status. The age group 70-79, the elementary educational level and the married patients predominated. The psychopathological symptoms and the distribution according to psychiatric disorders decreased among those with anxiety and sadness from 42 to 7 patients, respectively, once they were operated on of cataract and their vision was reestablished.

  1. A survey of senile dementia in the high background radiation areas in Yangjiang, China

    International Nuclear Information System (INIS)

    Li Jia; Su Gasaki, H.; Yang Yuhua

    1997-01-01

    Objective: To evaluate the effects of long-term low dose and low dose-rate ionizing radiation exposure on the prevalence rate of senile dementia, further assess the effects of low-dose radiation exposure on central nervous system and study the pathogen of senile dementia, and provide direct observational data of human beings. Methods: A cross-sectional study of the prevalence of senile dementia was carried out in high background radiation areas in Yangjiang, Guangdong Province, China. The survey was conducted in two stages. For the initial screening, Hasegawa Dementia Scale (HDS) was used for all subjects. In the second stage, the stage of diagnosis, special questionnaires of healthy state of old people were sued. The final diagnoses were made according to the third revised edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM III-R) of American Psychiatric Association. Results: 1018 inhabitants aged 65 years and over, including 513 persons in HBRA and 505 in CA were observed. According to DSM III-R, 61 cases (31 cases in HBRA and 30 cases in CA) of senile dementia were diagnosed. The prevalence rates of senile dementia are 6.04% in HBRA and 5.94% in CA, the total prevalence rate being 5.99%. Conclusion: No significant statistical difference in the prevalence rate of senile dementia between the two areas was found, suggesting that the prevalence rate of senile dementia in these areas is not associated with the high background radiation exposure

  2. Serum zinc, senile plaques, and neurofibrillary tangles: findings from the Nun Study.

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    Tully, C L; Snowdon, D A; Markesbery, W R

    1995-11-13

    Zinc appears to have a role in binding amyloid precursor protein in vitro, but it is not known whether zinc plays a role in senile plaque formation in vivo in humans. Serum zinc concentrations were available from 12 sisters who died in the Nun Study, a longitudinal study of aging and Alzheimer's disease. Fasting serum zinc concentrations, determined approximately 1 year before death, showed moderate to strong negative correlations with senile plaque counts in seven brain regions. In all brain regions combined, the age-adjusted negative correlations with serum zinc were statistically significant for total senile plaques and diffuse plaques, and suggestive for neuritic plaques. Thus serum zinc in the normal range may be associated with low senile plaque counts in the elderly.

  3. Senile anorexia in different geriatric settings in Italy.

    Science.gov (United States)

    Donini, L M; Dominguez, L J; Barbagallo, M; Savina, C; Castellaneta, E; Cucinotta, D; Fiorito, A; Inelmen, E M; Sergi, G; Enzi, G; Cannella, C

    2011-11-01

    Anorexia is the most frequent modification of eating habits in old age, which may lead to malnutrition and consequent morbidity and mortality in older adults. We aimed to estimate the prevalence and factors associated to anorexia in a sample of Italian older persons living in different settings. Our secondary aim was to evaluate the impact of senile anorexia on nutritional status and on eating habits, as well as on functional status. Observational study in nursing homes, in rehabilitation and acute geriatric wards, and in the community in four Italian regions (Lazio, Sicily, Emilia-Romagna, and Veneto). 526 over 65 years old participants were recruited; 218 free-living subjects, 213 from nursing homes, and 96 patients from rehabilitation and acute geriatric wards in the context of a National Research Project (PRIN) from the Italian Ministry of Instruction, University and Research (2005-067913 "Cause e Prevalenza dell'Anoressia senile"). Anthropometric and nutritional evaluation, olfactory, chewing, and swallowing capacity, food preferences, cognitive function, functional status, depression, quality of life, social aspects, prescribed drugs, and evaluation of gastrointestinal symptoms and pain. Laboratory parameters included prealbumin, albumin, transferrin, C-reactive protein, mucoprotein, lymphocyte count, as well as neurotransmitters leptin, and ghrelin. Anorexia was considered as ≥50% reduction in food intake vs. a standard meal (using 3-day "Club Francophone de Gériatrie et Nutrition" form), in absence of oral disorders preventing mastication. The overall prevalence of anorexia was 21.2% with higher values among hospitalized patients (34.1% women and 27.2% men in long-term facilities; 33.3% women and 26.7% men in rehabilitation and geriatric wards; 3.3% women and 11.3% men living in the community) and in the oldest persons. Anorexic subjects were significantly less self-sufficient and presented more often a compromised nutritional and cognitive status. Diet

  4. Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum

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    Xia Hu

    2017-06-01

    Full Text Available Genetic variations in the vacuolar protein sorting 10 protein (Vps10p family have been linked to Alzheimer’s disease (AD. Here we demonstrate deposition of fragments from the Vps10p member sortilin at senile plaques (SPs in aged and AD human cerebrum. Sortilin changes were characterized in postmortem brains with antibodies against the extracellular and intracellular C-terminal domains. The two antibodies exhibited identical labeling in normal human cerebrum, occurring in the somata and dendrites of cortical and hippocampal neurons. The C-terminal antibody also marked extracellular lesions in some aged and all AD cases, appearing as isolated fibrils, mini-plaques, dense-packing or circular mature-looking plaques. Sortilin and β-amyloid (Aβ deposition were correlated overtly in a region/lamina- and case-dependent manner as analyzed in the temporal lobe structures, with co-localized immunofluorescence seen at individual SPs. However, sortilin deposition rarely occurred around the pia, at vascular wall or in areas with typical diffuse Aβ deposition, with the labeling not enhanced by section pretreatment with heating or formic acid. Levels of a major sortilin fragment ~15 kDa, predicted to derive from the C-terminal region, were dramatically elevated in AD relative to control cortical lysates. Thus, sortilin fragments are a prominent constituent of the extracellularly deposited protein products at SPs in human cerebrum.

  5. Diagnosis related group grouping study of senile cataract patients based on E-CHAID algorithm

    Science.gov (United States)

    Luo, Ai-Jing; Chang, Wei-Fu; Xin, Zi-Rui; Ling, Hao; Li, Jun-Jie; Dai, Ping-Ping; Deng, Xuan-Tong; Zhang, Lei; Li, Shao-Gang

    2018-01-01

    AIM To figure out the contributed factors of the hospitalization expenses of senile cataract patients (HECP) and build up an area-specified senile cataract diagnosis related group (DRG) of Shanghai thereby formulating the reference range of HECP and providing scientific basis for the fair use and supervision of the health care insurance fund. METHODS The data was collected from the first page of the medical records of 22 097 hospitalized patients from tertiary hospitals in Shanghai from 2010 to 2012 whose major diagnosis were senile cataract. Firstly, we analyzed the influence factors of HECP using univariate and multivariate analysis. DRG grouping was conducted according to the exhaustive Chi-squared automatic interaction detector (E-CHAID) model, using HECP as target variable. Finally we evaluated the grouping results using non-parametric test such as Kruskal-Wallis H test, RIV, CV, etc. RESULTS The 6 DRGs were established as well as criterion of HECP, using age, sex, type of surgery and whether complications/comorbidities occurred as the key variables of classification node of senile cataract cases. CONCLUSION The grouping of senile cataract cases based on E-CHAID algorithm is reasonable. And the criterion of HECP based on DRG can provide a feasible way of management in the fair use and supervision of medical insurance fund. PMID:29487824

  6. Diagnosis related group grouping study of senile cataract patients based on E-CHAID algorithm.

    Science.gov (United States)

    Luo, Ai-Jing; Chang, Wei-Fu; Xin, Zi-Rui; Ling, Hao; Li, Jun-Jie; Dai, Ping-Ping; Deng, Xuan-Tong; Zhang, Lei; Li, Shao-Gang

    2018-01-01

    To figure out the contributed factors of the hospitalization expenses of senile cataract patients (HECP) and build up an area-specified senile cataract diagnosis related group (DRG) of Shanghai thereby formulating the reference range of HECP and providing scientific basis for the fair use and supervision of the health care insurance fund. The data was collected from the first page of the medical records of 22 097 hospitalized patients from tertiary hospitals in Shanghai from 2010 to 2012 whose major diagnosis were senile cataract. Firstly, we analyzed the influence factors of HECP using univariate and multivariate analysis. DRG grouping was conducted according to the exhaustive Chi-squared automatic interaction detector (E-CHAID) model, using HECP as target variable. Finally we evaluated the grouping results using non-parametric test such as Kruskal-Wallis H test, RIV, CV, etc. The 6 DRGs were established as well as criterion of HECP, using age, sex, type of surgery and whether complications/comorbidities occurred as the key variables of classification node of senile cataract cases. The grouping of senile cataract cases based on E-CHAID algorithm is reasonable. And the criterion of HECP based on DRG can provide a feasible way of management in the fair use and supervision of medical insurance fund.

  7. Diagnosis related group grouping study of senile cataract patients based on E-CHAID algorithm

    Directory of Open Access Journals (Sweden)

    Ai-Jing Luo

    2018-02-01

    Full Text Available AIM: To figure out the contributed factors of the hospitalization expenses of senile cataract patients (HECP and build up an area-specified senile cataract diagnosis related group (DRG of Shanghai thereby formulating the reference range of HECP and providing scientific basis for the fair use and supervision of the health care insurance fund. METHODS: The data was collected from the first page of the medical records of 22 097 hospitalized patients from tertiary hospitals in Shanghai from 2010 to 2012 whose major diagnosis were senile cataract. Firstly, we analyzed the influence factors of HECP using univariate and multivariate analysis. DRG grouping was conducted according to the exhaustive Chi-squared automatic interaction detector (E-CHAID model, using HECP as target variable. Finally we evaluated the grouping results using non-parametric test such as Kruskal-Wallis H test, RIV, CV, etc. RESULTS: The 6 DRGs were established as well as criterion of HECP, using age, sex, type of surgery and whether complications/comorbidities occurred as the key variables of classification node of senile cataract cases. CONCLUSION: The grouping of senile cataract cases based on E-CHAID algorithm is reasonable. And the criterion of HECP based on DRG can provide a feasible way of management in the fair use and supervision of medical insurance fund.

  8. Senile anorexia in acute-ward and rehabilitations settings.

    Science.gov (United States)

    Donini, L M; Savina, C; Piredda, M; Cucinotta, D; Fiorito, A; Inelmen, E M; Sergi, G; Domiguez, L J; Barbagallo, M; Cannella, C

    2008-10-01

    The most common pathological change in eating behaviour among older persons is anorexia, which accounts for a large percent of undernutrition in older adults. The main research aims are to determine, in a sample of acute and rehabilitation elderly subjects, the prevalence of anorexia of aging and the causes most impacting on senile anorexia. four different Units cooperated to this research study. Patients were recruited from geriatric acute and rehabilitation wards in Italy. Each Research Unit, for the estimation of the prevalence of anorexia in elderly subjects evaluated all the patients aged over 65 recruited from April 2006 to June 2007. Nutritional status, depression, social, functional and cognitive status, quality of life, health status, chewing, swallowing, sensorial functions were evaluated in anorexic patients and in a sample of "normal eating" elderly subjects. 96 anorexic subjects were selected in acute and rehabilitation wards (66 women; 81.5 +/- 7 years; 30 men: 81.8 +/- 8 years. The prevalence of anorexia in the sample was 33.3% in women and 26.7% in men. Anorexic subjects were older and more frequently needed help for shopping and cooking. A higher (although not statistically significant) level of comorbidity was present in anorexic subjects. These subjects reported constipation and epigastrium pain more frequently. Nutritional status parameters (MNA, anthropometry, blood parameters) were significantly worst in anorexic subjects whereas CRP was higher. Chewing and swallowing efficiencies were significantly impaired and eating patterns were different for anorexic subjects with a significant reduction of protein rich foods. consequences of anorexia can be extremely serious and deeply affect both patient's mobility, mortality and quality of life. Therefore, it is of utmost importance to perform a special evaluation of the nutritional risk, to constantly evaluate the nutritional status and feeding intake of older patients, to identify and treat the

  9. CT study in senile dementia of Alzheimer type

    Energy Technology Data Exchange (ETDEWEB)

    Yoshida, Ryoichi; Otomo, Eiichi [Yokufukai Geriatric Hospital, Tokyo (Japan)

    1989-10-01

    In order to evaluate the utility of cranial CT in diagnosis of senile dementia of Alzheimer type (SDAT), various CT findings were studied. CT scans of 62 cases of SDAT (83{plus minus}6 years old) were compared with those of 357 aged cases (means 78{plus minus}8 years old) without psychiatric and/or neurological illness (NC). To evaluate CT findings linear measurements of the ventricle, observation of sulci, brain atrophy ranking of microscopic observation were compared along with presence of periventricular lucency. When SDAT were compared with NC, the cases were divided into two groups by the age (the eighth decade, 80 years old or over) to avoid the influence of physiological brain atrophy. In SDAT there was a positive correlation between the volume of the lateral ventricle in autopsy brain and each index which demonstrates the size of the lateral ventricle on CT. In SDAT the incidence of cases with degree III or more was significantly higher than that in NC. It was 82.6% in SDAT, 15.7% in NC in the eighth decade and 92.3% in SDAT, 32.1% in NC in 80 years or over. The mean values of indexes of lateral ventricle enlargement in SDAT increased more than those in NC. In the eighth decade the mean lateral body ratio was 33.8% in SDAT, and 27.0% in NC and in 80 years or over, it was 33.1% in SDAT, 28.1% in NC. The differences between SDAT and NC were statistically significant. In SDAT the incidence of PVL was significantly higher than in NC. The mean maximum width of Sylvian fissure in SDAT was significantly larger than those in NC. However, the width of cingulate sulcus and central sulcus in SDAT were similar to those of NC. Brain atrophy ranking tended to increase with aging in SDAT, but this tendency was less clear than that in NC. In SDAT temporal atrophy was more significant than the other areas. Overall, CT revealed that brain atrophy in stage III patients was more remarkable than that in stage II patients.

  10. CT study in senile dementia of Alzheimer type

    International Nuclear Information System (INIS)

    Yoshida, Ryoichi; Otomo, Eiichi

    1989-01-01

    In order to evaluate the utility of cranial CT in diagnosis of senile dementia of Alzheimer type (SDAT), various CT findings were studied. CT scans of 62 cases of SDAT (83±6 years old) were compared with those of 357 aged cases (means 78±8 years old) without psychiatric and/or neurological illness (normal control NC). The methods of evaluating CT findings were linear measurements of the ventricle, observation of sulci, brain atrophy ranking of microscopic observation, and presence of periventricular lucency. When SDAT were compared with NC, the cases were divided into two groups by the age (the eighth decade, 80 years old or over) to avoid the influence of physiological brain atrophy. In SDAT there was a positive correlation between the volume of the lateral ventricle in autopsy brain and each index which demonstrates the size of the lateral ventricle on CT. In SDAT the incidence of cases with degree III or more was significantly higher than that in NC. It was 82.6% in SDAT, 15.7% in NC in the eighth decade and 92.3% in SDAT, 32.1% in NC in 80 years or over. The mean values of indexes of lateral ventricle enlargement in SDAT increased more than those in NC significantly. In the eighth decade the mean lateral body ratio was 33.8% in SDAT, and 27.0% in NC and in 80 years or over, it was 33.1% in SDAT, 28.1% in NC. The differences between SDAT and NC were statistically significant. In SDAT the incidence of PVL was significantly higher than in NC. The mean maximum width of Sylvian fissure in SDAT was significantly larger than those in NC. However, the width of cingulate sulcus and central sulcus in SDAT were similar to those of NC. Brain atrophy ranking tended to increase with aging in SDAT, but this tendency was less clear than that in NC. In SDAT temporal atrophy was significantly remarkable than the other areas. Overall, CT revealed that brain atrophy in stage III patients was more remarkable than that in stage II patients. (J.P.N.)

  11. Central venous catheter-related thrombosis in senile male patients: New risk factors and predictors.

    Science.gov (United States)

    Liu, Gao; Fu, Zhi-Qing; Zhu, Ping; Li, Shi-Jun

    2015-06-01

    Central venous catheterization (CVC)-related venous thrombosis is a common but serious clinical complication, thus prevention and treatment on this problem should be extensively investigated. In this research, we aimed to investigate the incidence rate of CVC-related venous thrombosis in senile patients and give a further discussion on the related risk factors and predictors. A total of 324 hospitalized senile male patients subjected to CVC were selected. Retrospective investigation and analysis were conducted on age, underlying diseases, clinical medications, catheterization position and side, catheter retention time, and incidence of CVC-related venous thrombosis complications. Basic laboratory test results during catheterization and thrombogenesis were also collected and analyzed. Among the 324 patients, 20 cases (6.17%) of CVC-related venous thrombosis were diagnoseds. The incidence rate of CVC-related venous thrombosis in subclavian vein catheterization was significantly lower than that in femoral vein catheterization (Pcatheterization (Pcatheterization and internal jugular vein catheterization (Pvenous thrombosis history (Pvenous thrombosis in senile male patients. Subclavian vein catheterization was the most appropriate choice among senile patients to decrease the incidence of CVC-related venous thrombosis. Previous venous thrombosis history, high lactate dehydrogenase level, low HDL level, and low albumin level were important risk factors in predicting CVC-related venous thrombosis.

  12. Evaluation of the Costs of Caring for the Senile Demented Elderly: A Pilot Study.

    Science.gov (United States)

    Hu, Teh-wei; And Others

    1986-01-01

    Evaluated economic costs for nursing home patients and elderly living in their own homes. Using time records compiled by nurses or family members, the costs incurred annually in caring for a senile demented elderly person at home were estimated to average $11,735, and in a nursing home, $22,458. (Author/BL)

  13. Topical Human Epidermal Growth Factor in the Treatment of Senile Purpura and the Prevention of Dermatoporosis.

    Science.gov (United States)

    McKnight, Braden; Seidel, Rachel; Moy, Ron

    2015-10-01

    Senile purpura presents itself as a largely unexplored challenge as it has been long thought of as a benign condition without long-term health sequelae. It is becoming increasingly accepted that skin aging not only results in cosmetic disturbances, but as a functional ones. With modern increases in lifespan, skin atrophy associated with solar damage is presenting as a clinically significant inability to mechanically protect patients. This chronic cutaneous insufficiency/fragility syndrome was recently termed dermatoporosis and senile purpura appears to be a visible marker of early stage dysfunction. To examine the effects of topically human epidermal growth factor on the clinical presence of senile purpura and its effect on skin thickness as measured via cutaneous ultrasound. Six subjects applied human epidermal growth factor morning and night for six weeks. Clinical outcomes were evaluated by comparing initial clinical photos to 6-week photos and performing a blinded investigator's global assessment (IGA). Skin thickness was evaluated via cutaneous ultrasound measurement. Ultrasound measurements indicated a mean skin thickening of 195.2 ± 35.7 um (SEM) over 6 weeks. The average number of purpuric lesions decreased from 15 ± 4.6 (SEM) to 2.3 ± 0.7 (SEM) over that same period. Senile purpura presents itself as a cosmetic disturbance posing significant psychological distress and serves as a marker of the severity of skin thinning. In this study, we demonstrate that topical h-EGF diminishes the appearance of senile purpura by thickening skin and may help prevent the development of late stage dermatoporosis.

  14. Effects of Simulated Heat Waves on Cardiovascular Functions in Senile Mice

    Directory of Open Access Journals (Sweden)

    Xiakun Zhang

    2014-08-01

    Full Text Available The mechanism of the effects of simulated heat waves on cardiovascular disease in senile mice was investigated. Heat waves were simulated in a TEM1880 meteorological environment simulation chamber, according to a heat wave that occurred in July 2001 in Nanjing, China. Eighteen senile mice were divided into control, heat wave, and heat wave BH4 groups, respectively. Mice in the heat wave and heat wave BH4 groups were exposed to simulated heat waves in the simulation chamber. The levels of ET-1, NO, HSP60, SOD, TNF, sICAM-1, and HIF-1α in each group of mice were measured after heat wave simulation. Results show that heat waves decreased SOD activity in the myocardial tissue of senile mice, increased NO, HSP60, TNF, sICAM-1, and HIF-1α levels, and slightly decreased ET-1 levels, BH4 can relieve the effects of heat waves on various biological indicators. After a comprehensive analysis of the experiments above, we draw the followings conclusions regarding the influence of heat waves on senile mice: excess HSP60 activated immune cells, and induced endothelial cells and macrophages to secrete large amounts of ICAM-1, TNF-α, and other inflammatory cytokines, it also activated the inflammation response in the body and damaged the coronary endothelial cell structure, which increased the permeability of blood vessel intima and decreased SOD activity in cardiac tissues. The oxidation of lipoproteins in the blood increased, and large amounts of cholesterol were generated. Cholesterol penetrated the intima and deposited on the blood vessel wall, forming atherosclerosis and leading to the occurrence of cardiovascular disease in senile mice. These results maybe are useful for studying the effects of heat waves on elderly humans, which we discussed in the discussion chapter.

  15. Investigation of elemental models in senile dementia and depressives using neutron activation analysis

    International Nuclear Information System (INIS)

    Akanle, O.A.; Spyrou, N.M.; Damyanova, A.A.; Ali, L.

    1987-01-01

    Instrumental neutron activation analysis was used to determine the concentration of a range of elements in hair and blood samples, separated into erythrocytes and plasma, obtained from women, senile demented (9) and depressives (16), and their controls (17 and 9). The results suggest that the senile dementia group has significantly higher Al concentrations in erythrocytes and hair. Zn concentrations determined in the erythrocytes and plasma of these subjects were lower compared to the control values. Vanadium levels above detection limit for the element were found in seven cases out of a total of sixteen in the depressive group. Vanadium was also found to be at higher concentrations in the hair of the depressive group compared to the controls. Again no significant correlation was found to exist between the concentration of vanadium in hair and in erythrocyte sample for these seven subjects. (author) 17 refs.; 4 tables

  16. Analysis of computed X-ray tomography of the brain in incontinence patients with senile dementia

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Yasuyuki; Machida, Toyohei; Oishi, Yukihiko [Jikei Univ., Tokyo (Japan). School of Medicine; Kamachi, Chikahumi; Okabe, Tsutomu; Akazawa, Kouhei; Takasaka, Satoshi

    1994-02-01

    To evaluate the condition of incontinence in patients with senile dementia, we performed computed tomography X-rays to the brain and analyzed the relationship among the circulatory defect of the brain, the brain atrophy and the degree of incontinence. There were 92 patients subjected to this study who were hospitalised due to senile dementia; 74 patients had vascular dementia, 10 patients had senile dementia of Alzheimer type, and 8 patients had the mixed type. (age range: 54-95 years; mean: 80.3 years). The degree of incontinence in these patients varied as follows: 18 patients with continence, 16 patients with moderate incontinence, 58 patients with total incontinence. The diagnosis of circulatory defect of the brain was based on computed tomography observation of periventricular lucency (P.V.L.), and the degree of brain atrophy was evaluated based on 4 criteria: the Lateral body ratio, the Huckman number, the Evans ratio, and the enlargement of the subarachnoid space. Among the 92 patients, P.V.L. was present in 31 patients, among them 27 patients suffered from incontinence. There was a significant correlation between P.V.L. and incontinence (p<0.001). As the incontinence progressively worsened (Continence, Moderate incontinence, Total incontinence), the lateral body ratio increased to 24.8, 27.8, 28.6, (p<0.05). The Huckman number also increased to 18.3, 19.3, 21.3, (p<0.01), and the evans ratio likewise 29.9, 32.3, 33.7 (p<0.01). The enlargement of the subarachnoid space was also correlated with the severity of incontinence. We conclude that urinary incontinence originating from senile dememtia is connected to brain atrophy and is strongly influenced by the circulatory disorders of the brain. (author).

  17. Scalp and Body Acupuncture for Treatment of Senile Insomnia-A Report of 83 Cases

    Institute of Scientific and Technical Information of China (English)

    卢泽强

    2002-01-01

    @@ The author has in recent years treated 83 cases of senile insomnia with scalp and body acupuncture. Meanwhile, 35 cases in the control group were treated with western and Chinese drugs. The therapeutic results in the treatment group were superior to that of nitrazapam and An Shen Bu Nao Ye (安神补脑液Sedative and Brain-invigorating Fluid) used in the control group. A report of the treatment follows.

  18. Clinical study of a retinoic acid-loaded microneedle patch for seborrheic keratosis or senile lentigo.

    Science.gov (United States)

    Hirobe, Sachiko; Otsuka, Risa; Iioka, Hiroshi; Quan, Ying-Shu; Kamiyama, Fumio; Asada, Hideo; Okada, Naoki; Nakagawa, Shinsaku

    2017-01-01

    Pigmented lesions such as of seborrheic keratosis and senile lentigo, which are commonly seen on skin of people>50years of age, are considered unattractive and disfiguring because of their negative psychological impact. Drug therapy using all-trans retinoic acid (ATRA) is an attractive option for self-treatment at home. We have developed an ATRA-loaded microneedle patch (ATRA-MN) and confirmed the pharmacological effects of ATRA-MN application in mice. Here, we describe a clinical study to evaluate the safety and efficacy of ATRA-MN in subjects with seborrheic keratosis or senile lentigo. ATRA-MN was applied to the lesion site of each subject for 6h once per week for 4weeks. The skin irritation reaction was scored to assess adverse reactions and blood tests were performed to evaluate the presence of systemic adverse reactions. To assess the treatment effect using ATRA-MN, the desquamation and whitening ability of the investigational skin was observed. Desquamation of the stratum corneum was observed following four ATRA-MN applications at 1-week intervals, but ATRA-MN applications did not induce severe local or systemic adverse effects. These results showed that ATRA-MN treatment is promising as a safe and effective therapy for seborrheic keratosis and senile lentigo. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. [Aspects of senile dementia in ancient Rome: literary fiction and factual reality].

    Science.gov (United States)

    Moog, Ferdinand Peter; Schäfer, Daniel

    2007-01-01

    Old people and their pecularities have been the object of writers since the beginning of Western literature. The aim of this study is to verify the social and juridical significance of senile dementia in ancient Rome. Among the few relevant sources the 10th satire of Juvenal attracts attention. It describes a demented patient who revises his succession in favour of a lady with bad reputation. Logically, we wonder whether such dispositions were possible and after all legally binding. Or did Juvenal exaggerate? A look at the Roman legislation shows: Since the Twelve Tablet Law there were instruments to control or to help demented people. This meant care in the sense of the today's curatorship or guardianship. These measures were supposed to prevent extravagancy or doing business and legal acts like marriages or last wills in the state of diminished responsibility. Nevertheless, it must be assumed that there was a considerable discrepancy between juridical theory and daily practice, because the position of the "pater familias" was virtually untouchable, the individual freedom of the full citizen was firmly underlined and the Roman civil law allowed only little executive interferences. Juvenal's bizarre example should not only be taken as good literary fiction. It might reflect the sad, but nevertheless probable reality of the people directly concerned. Apart from that it has to be said that senile dementia played only a minor role in Roman legislation. Mainly because there were considerably less very old people--and in particular people with senile dementia--than today.

  20. Antioxidant status in diabetic and non-diabetic senile patients, with cataract or cardiovascular complications

    International Nuclear Information System (INIS)

    Gul, A.; Rahman, Muhammad A.

    2008-01-01

    Objective was to assess the total antioxidant status in diabetic and non-diabetic senile patients, with cataract or cardiovascular complications, and without complications. A comparative study on 186 senile patients and control subjects was carried from March 2004 to November 2006 on patients from Ziauddin University Hospital, Karachi, Pakistan. Among them 33 were diabetic patients without any clinical evidence of chronic diabetic complications, 32 with cardiovascular complications, 30 non-diabetic patients with cardiovascular complications, 30 diabetic patients with cataract and 31 apparently normal, age, gender and weight matched control subjects were investigated. All patients were selected on clinical grounds. Total antioxidant status was significantly decreased (p<0.001) in all diabetic patients with and without complications and non-diabetic patients with same complications (155 patients) as compared with control subjects (31 subjects). Fasting plasma glucose was increased (p<0.001) in all diabetic patients with and without complications (95 patients), and correlated significantly with glycosylated hemoglobin (HbA1c) and serum fructosamine concentrations. Fasting plasma glucose, HbA1c, and serum fructosamine were not different in diabetic patients with and without complications. Fasting plasma glucose, HbA1c, serum fructosamine and total serum protein were not different in non-diabetic patients with the same complications as compared with control subjects. Total antioxidant status is decreased in diabetic and non-diabetic senile patients with the same complication as compared with same complication as compared with control subjects. Some other factors may be responsible for decease antioxidant status. (author)

  1. [Clinical study of medicinal-cake-separated moxibustion for senile osteoporosis].

    Science.gov (United States)

    Zeng, Yuqing; Bi, Dingyan; Yi, Zhan; Lu, Jianwei; Zhong, Fuhua; Jiang, Binfeng

    2017-05-12

    To explore the clinical efficacy and partial mechanism of medicinal-cake-separated moxibustion for senile osteoporosis. Sixty cases of senile osteoporosis were randomly divided into an observation group and a control group according to the random digits table, 30 cases in each one. The two groups were both treated with basic treatment of western medicine. The acupoints included four groups:① Dazhui (GV 14), Dazhu (BL 11) and Ganshu (BL 18); ② Zhongwan (CV 12), Danzhong (CV 17) and Zusanli (ST 36); ③ Pishu (BL 20), Shenshu (BL 23) and Mingmen (GV 4); ④ Shenque (CV 8) and Guanyuan (CV 4). Each group of acupoints was selected for one treatment. The observation group was treated with medicinal-cake-separated moxibustion, and the medicinal cake was consisted of fructus psoraleae (30 g), prepared rehmannia root (30 g), atractylodes (30 g), codonopsis pilosula (30 g), epimedium herb (20 g), rhizoma curculiginis (20 g), syzygium aromaticum (5 g) and cinnamon (5 g). The control group was treated with wheat-flour-cake moxibustion. Each acupoint was treated with 5 moxa cones in the two groups. The treatment was given once every other day for six months. The symptom score, lumbar and hip bone mineral density (BMD), serum type Ⅰ procollagen amino-terminal propeptide (PINP) and serum β-type Ⅰ collagen carboxy-terminal peptide (β-CTX) were observed before and after treatment. After treatment, the symptom score and serum β-CTX were significantly lowered (all P cake-separated moxibustion has significant efficacy for senile osteoporosis, which is superior to wheat-cake-se-parated moxibustion.

  2. [Estimation of nutrition of elderly and senile patients with surgical diseases at home].

    Science.gov (United States)

    Malikov, D I

    2005-01-01

    Analysis of estimation of nutrition 500 of elderly and senile patients with surgical disease at home. The diets of patients are characterised by foods rich of animal protein and carbohydrate. But a dificienny of meat, fish, dairy products frent, berries is marhed. The diets thas dificiency in rations of patients are characterized by irrational set basic food products, cannot provide daily needs for nutrients: animal protein, vitamins C, A, vitamins B group, beta-carotene and mineral element--Ca, Mg, P, Zn, Se. Entering of nutrional substance, such as vitamins, and mineral elements with a food is reduced in dietary restrictions, deficiency means, residence in country-side.

  3. A study of 99mTc-HM-PAO brain SPECT in the senile parkinson's disease

    International Nuclear Information System (INIS)

    Chen Wenxin; Lin Xiangtong; Song Wenzhong; Liu Yongchang

    1996-01-01

    Thirty-three cases of senile Parkinson's disease (PD) imaged by 99m Tc-HM-PAO brain SPECT were reported. 66.7% of the patients had cortical hypoperfusion and 18.2% showed asymmetrical hypoperfusion in the basal ganglia. Such a finding was not related with the Hoehn-Yahr stage and the laterality of motor symptoms. If complicated with dementia, the SPECT brain imaging showed similar pattern in Alzheimer's disease with diffuse hypoperfusion in cortical area reflecting widespread pathological changes in tremor paralysis

  4. Shugan Jieyu Yin for Treatment of Senile Depression--A Clinical Report of 84 Cases

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ TCM holds that depression is, in most cases,resulted from injuries of the seven emotions and/or from stagnation of qi. The principle of treatment should be mainly to relieve the depressed liver and to regulate the flow of qi, supplemented by nourishing the blood and the liver, eliminating heat and irritability, promoting blood circulation by removing blood stasis, tranquilizing the mind, and dredging the collaterals to stop pain. Since 1995, we have treated 84 cases of senile depression with the prescription of Shugan Jieyu Yin (舒肝解郁饮Decoction for Relieving the Depressed Liver), and obtained satisfactory therapeutic results. A report follows.

  5. Spots before the eyes: A prevalence and clinicoradiological study of senile scleral plaques

    International Nuclear Information System (INIS)

    Moseley, I.

    2000-01-01

    AIMS: To investigate the prevalence and clinical associations of senile scleral plaques. METHODS: Unselected, consecutive computed tomographic (CT) images of elderly people were reviewed for the presence of calcification indicating senile scleral plaques. RESULTS: No definite calcification was seen in 100 men or 100 women aged 60-69 years; equivocal changes were seen in one woman. There were three definite examples and one equivocal case of calcification in 100 women and four definite cases in 100 men aged 70-79 years. However, in a group of 71 men and women patients aged 80 years or more, 16 definite cases were seen, indicating a prevalence of 22%. CONCLUSIONS: Apart from advanced age, and a mild association with the extent of calcification of the carotid siphon, no clinical or radiological features were identified which consistently characterized a total of 28 patients with this form of ocular calcification; an association with cataract probably reflected simply the recruitment base. Scleral plaques would appear to be a degenerative phenomenon without clinical significance, most likely to be detected in patients presenting with unrelated ophthalmological complaints. Moseley, I. (2000)

  6. Association SOD2 Polymorphism(-9C/T and Senile Cataract

    Directory of Open Access Journals (Sweden)

    A.R. Nakhaee

    2017-01-01

    Full Text Available Introduction: One of the most common causes of blindness around the world is cataract, which is a multifactorial eye disease and a major cause the loss lens transparency in the aging population. Oxidative stress is a major factor that often leads to cataract formation. Oxidative stress is defined as a disturbance in the balance of reactive oxygen species (ROS production  and antioxidant defenses, including enzymatic and non-enzymatic systems. One of the defense systems against free radicals is superoxide dismutase II (Mn SOD enzyme. SOD enzyme catalyses the dismutation of superoxide anion to O2 and H2O2. Several polymorphism  have been found associated with SOD2 gene. Present study has been done to evaluaet effects of genetic polymorphism, including SOD2 C/T polymorphism in the -9 position in senile cataract patiens and normal individuals. Material and methods: in this case- control study, there are 120 patients with senile cataract and 104 healthy people. We collected 2ml of whole blood in tubes containing EDTA, and then DNA extraction was performed. Polymorphisms were detected by PCR–RFLP technique. Findings: The distribution of CC, CT, TT genotypes of SOD2 gene were 28.3%, 43.3% and 28.3% in the patient group and 24%, 48.1% and 27.9% in the healthy group, respectively. Conclusion: No significant difference in the distribution SOD2 C/T polymorphism was observed between cases and controls. 

  7. Probability of developing severe sepsis in patients of elderly and senile age with necrotic erysipelas

    Directory of Open Access Journals (Sweden)

    Shapkin Yu.G.

    2015-06-01

    Full Text Available Objective: the probable determination of severe sepsis in patients of elderly and senile age with necrotic erysipelas based on a comprehensive assessment (clinical examination using systems — scales and determination of the level markers of SIRS. Material and methods. The analysis of peculiarities of necrotic erysipelas clinical course in 59 patients. The first group consisted of 17 patients with severe sepsis, the second — 18 patients with sepsis without multiple organ failure, in the comparison group —22 patients with local infection. We determined albumin, urea, creatinine, pro-calcitonin of plasma. The scale SAPS III was used to quantify SIRS, scale SOFA —to determine the extent of damage to organs and systems. Results. The most sensitive marker of developing sepsis in patients with necrotic erysipelas was procalcitonin. The second important indicator of SIRS severity in patients with necrotic erysipelas was the blood albumin. Scale SAPS III also allows to select a group of patients with high risk of developing severe sepsis. Use of the SOFA to predict the scale has been found out to be less important. Conclusion. A comprehensive assessment of the severity of the condition by scale SAPS III in combination with determining the levels of procalcitonin and plasma albumin is advisable to apply for prediction the probability of developing severe sepsis in patients of elderly and senile age with necrotic erysipelas. For the last indicator it is important to assess of absolute values and the decrease of its concentration.

  8. Cholinergic and dopaminergic activities in senile dementia of Lewy body type.

    Science.gov (United States)

    Perry, E K; Marshall, E; Perry, R H; Irving, D; Smith, C J; Blessed, G; Fairbairn, A F

    1990-01-01

    Analyses of brain tissue in a recently identified group of elderly demented patients suggest a neurochemical basis for some of the clinical features. Senile dementia of the Lewy body type (SDLT) can be distinguished from classical Alzheimer disease (AD) clinically by its acute presentation with confusion frequently accompanied by visual hallucinations, and neuropathologically by the presence of Lewy bodies and senile plaques (but not generally neurofibrillary tangles) in the cerebral cortex. Reductions in the cortical cholinergic enzyme choline acetyltransferase were more pronounced in individuals with (80%) compared to those without (50%) hallucinations and correlated strongly with mental test scores in the group as a whole. In the caudate nucleus, dopamine levels were related to the number of neurons in the substantia nigra, there being a 40-60% loss of both in SDLT--probably accounting for mild extrapyramidal features in some of these cases--compared with an 80% loss in Parkinson disease and no change in AD. The cholinergic correlates of mental impairment in SDLT together with the relative absence of cortical neurofibrillary tangles and evidence for postsynaptic cholinergic receptor compensation raise the question of whether this type of dementia may be more amenable to cholinotherapy than classical AD.

  9. [Clinical observation on auricular point magnetotherapy for treatment of senile low back pain].

    Science.gov (United States)

    Sun, Gui-Ping

    2007-02-01

    To compare the therapeutic effects of auricular point magnetotherapy and auricular point sticking of Vaccaria seed on senile low back pain. Sixty cases, aged 60 or over 60 years with back pain, were randomly divided into 2 groups, a control group and a test group. The control group were treated with auricular sticking of Vaccaria seed with no pressing, and the test group with sticking magnetic bead of 66 gauss each piece with no pressing. Auricular points, Shenmen, Kidney, Bladder, Yaodizhui, Gluteus, Liver and Spleen were selected. Three weeks constituted one course. The effects before, during and after the course were assessed by questionnaire about back pain. Compared with the control group, in the test group the back pain was more effectively improved, including reducing pain and numbness in the back and the legs, decreasing the disorder of physical strength induced by this disease, and improving daily life quality of the patient. Follow-up survey for 2-4 weeks showed the effects still were kept. Auricular magnetotherapy can effectively improve senile back pain.

  10. Quantitative measurement of bone mineral contents in patients with senile osteoporosis and chronic renal failure

    International Nuclear Information System (INIS)

    Fukuda, Teruo

    1985-01-01

    Computed tomography using X-ray (XCT) and single photon emission computed tomography (SPECT) using sup(99m)Tc-MDP of the skull were performed in patients with ''senile osteoporosis'' and with chronic renal failure, in order to quantitatively determine bone mineral contents. XCT: In females with postmenopausal osteoporosis (6th decade), the EMI number of frontal bone was significantly low compared with that of control group, of the same age. The EMI number in ''senile osteoporosis'' correlated with the value of serum 25 (OH) D and 1 α - 25 (OH) 2 D. The EMI number in hemodialyzed patients was significantly low compared with that in the control group. On the other hand, the EMI number in non-hemodialyzed chronic renal failure patients showed no significant difference compared with findings in the control group. The EMI number of the frontal bone in patients with partial parathyroidectomy showed a slight rise compared with findings before surgery. Bone scintigram, Bone scan SPECT: Positive scan was seen in patients with long term hemodialysis and increased values of serum Alk-Pase and PTH were often apparent. Scintigraphic improvement in patients with renal osteodystrophy treated with vitamin D 3 showed a good correlation with improvement in serum Alk-Pase values. On SPECT, frontal bone activity in patients with renal osteodystrophy was significantly high compared with that in the control group. In case of renal osteodystrophy treated with partial parathyroidectomy, the frontal bone activity was markedly decreased compared with findings before surgery. (J.P.N.)

  11. Effects of TimeSlips on Cornell Scale for Depression in Dementia scores of senile dementia patients

    Directory of Open Access Journals (Sweden)

    Hui-Ying Chen

    2016-03-01

    Conclusion: TimeSlips is beneficial to relieve depressive symptoms and ameliorate the emotions of mild or moderate senile dementia patients, thus improving their life quality and reducing the burden of their caregivers. A large-scale experimental research on TimeSlips with rigorous design is proposed for further studies.

  12. Clinical significance of white matter hyperintensities in MRI in senile dementia of the Alzheimer type

    International Nuclear Information System (INIS)

    Takita, Masashi

    1996-01-01

    To elucidate clinical significance of white matter hyperintensities (WMH) in MRI, fifty patients with senile dementia of the Alzheimer type (SDAT) and twenty normal controls were studied. Twenty nine patients with SDAT (58.0%) had periventricular hyperintensities (PVH) and twenty three patients with SDAT (46.0%) had deep white matter hyperintensities (DWMH). Eight controls (40.0%) had PVH and ten controls (50.0%) had DWMH. There were no significant differences in frequency of WMH between patients with SDAT and normal controls. Past history of hypertension was more frequent in patients with PVH or DWMH than in patients without them. Serum cholesterol level was higher in patients with DWMH than in patients without them. However there were no significant differences in the other clinical features between patients with WMH and patients without them. The results of present study suggest that DWMH in patients with SDAT is associated with cerebrovascular risk factors such as hypertension and hyperlipidemia. (author)

  13. [Efficiency of rehabilitation of elderly and senile patients after an ischemic stroke].

    Science.gov (United States)

    Miakotnykh, V S; Borovkova, T A; Miakotnykh, K V; Lespukh, N I

    2011-01-01

    Productivity of a wide medical rehabilitation in 296 patients who have had an ischemic stroke was studied. In the period of rehabilitation treatment 186 patients of 70-84 years composed the basic group, 110 in the control group were of 33-60 years. Clinical, social, psychological indicators in dynamics were compared; results of variety of tool and laboratory researches were estimated. Possibility of high efficiency of medical rehabilitation in elderly and senile age is stated. This efficiency depends on expressiveness of impellent defect, the period of a stroke, somatic diseases and on depressive infringements. Positive shifts in character of bioelectric activity of a brain and also activation of non-vascular link of a cerebral metabolism in comparison with vascular one can serve as prognosis criteria of success of rehabilitation of the elderly.

  14. Evaluation of radioimmunoassay for renal functions in senile patients with cor pulmonale without respiratory failure

    International Nuclear Information System (INIS)

    Fu Benqi; Chen Mingxi; Zhou Gangyi; Zhang Zhengzhong

    1995-01-01

    The results of RIA about serum β 2 -MG and urine β 2 -MG, Alb, IgG in the senile patients with cor pulmonale are reported. The contents of sβ 2 -MG, uβ 2 -MG, uAlb in non-respiratory failure group are higher than that of the control group. The contents of sβ 2 -MG, uβ 2 -MG, uAlb and uIgG in the respiratory failure group are higher than that of the non-respiratory failure group. The results show that the renal glamorous and renal tubules functions are slightly damaged in non-respiratory failure group, while functions of the respiratory failure group become worse

  15. Cognitive decline in patients with Alzheimer's disease, vascular dementia and senile dementia of Lewy body type.

    Science.gov (United States)

    Ballard, C; Patel, A; Oyebode, F; Wilcock, G

    1996-05-01

    One hundred and twenty-four patients with DSM-III-R dementia were assessed with a standardized battery which included the Geriatric Mental State Schedule, the History and Aetiology Schedule, the Secondary Dementia Schedule and the CAMCOG. Patients with Alzheimer's disease, vascular dementia and senile dementia of Lewy body type (SDLT) all had a similar degree of cognitive impairment at the time of the baseline interview. Patients with Alzheimer's disease and vascular dementia each experienced a mean decline of 27 points in patients with SDLT. Patients with SDLT had a significantly greater decline of verbal fluency than both the other groups. Women were significantly more impaired than men at the time of the baseline assessment but experienced a similar decline during the year of follow-up.

  16. Systemic aspirin and systemic vitamin E in senile cataracts : cataract V

    Directory of Open Access Journals (Sweden)

    Sharma Y

    1989-01-01

    Full Text Available We undertook a prospective study in senile cataract patients using systemic aspirin and systemic vitamin E. Vitamin E treated eyes did show less progression of PSC opacities extent and less new nuclear opacities during the follow-up, but overall vitamin E treated eyes did no better than the control group eyes. More eyes in systemic aspirin treated group maintained the initial vision and loss of vision in the aspirin group was also less marked. Aspirin also caused a significant less mean increase in cortical opacity extent, nuclear/opacity and density and PSC opacity extent and density as well as in ophthalmoscopically graded opacity extent and density. We suggest that aspirin is a potential drug which should be further evaluated in large double blind photodocumentated studies. The present data does not justify the recommendation that aspirin be prescribed for slowing down cataract progression. This must await large studies and confirmation.

  17. Use of placental extract for the treatment of myopic and senile chorio-retinal dystrophies.

    Science.gov (United States)

    Girotto, G; Malinverni, W

    1982-01-01

    After an examination of the literature, the authors evaluate the activity of placenta extract in 34 subjects suffering from chorio-retinal dystrophy of different types (myopic and senile) and of different degrees of anatomo-functional alteration. The parameters used for this study were visual acuity, the luminous sense, the visual field and the electrophysiological activity of the retina. The aqueous solution was administered by intramuscular route at a daily dose of 3 ml (equivalent to 1,80 g of fresh organ) during 20 days; the parameters were tested before and at the end of the treatment. The results obtained during this study show that the parameters were improved, in different degrees, by the administration of the placenta extract. This is clearly demonstrated by the significant improvement in the luminous sense.

  18. Stereoselective determination of amino acids in beta-amyloid peptides and senile plaques.

    Science.gov (United States)

    Thorsén, G; Bergquist, J; Westlind-Danielsson, A; Josefsson, B

    2001-06-01

    A novel method for the determination of the enantiomeric composition of peptides is presented. In this paper, the focus has been on beta-amyloid peptides from deceased Alzheimer's disease patients. The peptides are hydrolyzed using mineral acid. The free amino acids are derivatized with the chiral reagent (+)- or (-)-1-(9-anthryl)-2-propyl chloroformate and subsequently separated using micellar electrokinetic chromatography (MEKC) and detected using laser-induced fluorescence (LIF) detection. The high separation efficiency of the MEKC-LIF system, yielding approximately 1 million theoretical plates/m for most amino acids, facilitates the simultaneous chiral determination of nine amino acids. The samples that have been analyzed were standard 1-40 beta-amyloid peptides, in vitro precipitated beta-amyloid fibrils, and human senile plaque samples.

  19. The venous manifestations of pulse wave encephalopathy: windkessel dysfunction in normal aging and senile dementia

    Energy Technology Data Exchange (ETDEWEB)

    Bateman, Grant A. [Locked Bag 1, Newcastle Region Mail Center, Department of Medical Imaging, John Hunter Hospital, Newcastle (Australia); Levi, Christopher R.; Wang, Yang; Lovett, Elizabeth C. [Hunter Medical Research Institute, Clinical Neurosciences Program, Newcastle (Australia); Schofield, Peter [James Fletcher Hospital, Neuropsychiatry Unit, Newcastle (Australia)

    2008-06-15

    Cerebral arterial, venous and cerebrospinal fluid (CSF) pulsations are closely coupled and this produces pulsation dampening or the windkessel effect. Normal pressure hydrocephalus is a manifestation of the breakdown of this windkessel effect with altered CSF and venous pulsations being noted. The aim of this study was to show that dysfunction of the windkessel mechanism is also a component of normal aging and senile dementia. The study group comprised 24 patients classified as either early senile dementia of Alzheimer's type (SDAT) or vascular dementia (VaD). The patients with dementia were compared with 12 age-matched non-cognitively impaired subjects, and 12 normal young individuals were compared with the normal aging group. MRI flow quantification was used to measure the nonpulsatile and pulsatile components of blood flow as well as the pulsation at the tentorial incisura. With normal aging blood flow decreased but arterial pulsations increased in volume by 49% (P = 0.003). The CSF vented via the tentorial incisura does not change significantly with age and therefore increased venous pulsation is necessary. In patients with VaD the arterial pulse volume was higher by 24% and the straight sinus pulsation was higher by 57% than in normal aging subjects (P = 0.05 and P = 0.03, respectively). In patients with SDAT the total venous pulsation volumes were similar to those in normal aging subjects but there was less basal sinus pulsation. Normal aging, SDAT and VaD are associated with alterations in venous pulsation due to a breakdown of the windkessel effect. (orig.)

  20. ASSOCIATION BETWEEN REFRACTIVE ERRORS AND SENILE CATARACT IN RURAL AREA OF WESTERN MAHARASHTRA

    Directory of Open Access Journals (Sweden)

    Chaudhari Sagar V, Shelke Sanjay T, BangalSurekha V, Bhandari Akshay J, Kulkarni Ameya A

    2015-04-01

    Full Text Available Purpose: To study the association between refractive errors and senile cataract in rural area of western MaharashtraMaterials & Methods: It is a prospective cross sectional study carried out on 420 eyes of 210 patients with senile cataract was included in the study. The age and sex of the patient, grade and the refractive status of the cataract of the eyes were recorded. The grade of the cataract was recorded by the LOCS III (Lens Opacities Classification System, version III. Refractive status was measured subjectively using retinoscope and refractive error for each eye was converted into spherical equivalent units. Results: The age variation in the study was between 60-85 years.The maximum number of patients was in the age group of 60-65 years.The spherical equivalent ranged between -3.0 D to +4.25D.45.95% of the study population had a spherical equivalent between -2 to -1.73.81 % of the study population had a myopic refraction.20% had a hypermetropic refraction. Percentage of patients with a score of nuclear opalescence and colour between 1.0-2.0 was 41.90%, between 2.1-3.0 was 26.67% and above 3.0 was 31.43%.Percentage of patients with a score of cortical cataract between 0.1-1.0 was 69.76% and with a grade between 2.1-3.0 was 26.91 %. Percentage of patients with a score of posterior subcapsular cataract between 0.1-1.0 was 53.57% and with a grade between 2.1-3.0 was 39.05%. Conclusion: The myopic refraction was associated with nuclear, cortical and posterior subcapsular cataract and this refractive error was stastically significant with nuclear, cortical and posterior subcapsular cataract.

  1. Effect of catalpol on senile plaques and spatial learning and memory ability in amyloid-β protein precursor/presenilin 1 double transgenic mice

    Institute of Scientific and Technical Information of China (English)

    宋冲

    2013-01-01

    Objective To investigate whether catalpol affects senile plaque formation and spatial learning and memory ability in the amyloid-βprotein precursor/presenilin 1(APP/PS1)double transgenic mice.Methods

  2. Effect Of GAMMA Irradiated Thyme As Natural Antioxidant On Hypercholesterolemia Senile Rats

    International Nuclear Information System (INIS)

    El-Shahat, A.N.; Hamza, R.G.

    2011-01-01

    Hypercholesterolemia, high cholesterol diet and oxidative stress increase serum total cholesterol and LDL-cholesterol levels resulting in increased risk for development of atherosclerosis. Thyme (as antioxidant) has been commonly used in foods mainly for the flavour and preservation and also as herbal medicinal products. Antioxidants play an important role in inhibiting and scavenging free radicals, thus, providing protection to humans against infectious and degenerative diseases. This study was carried out to determine the effect of using thyme as supplement on serum levels of lipids, glucose and lipid peroxidation in hypercholesterolemia senile rats. GC-MS analysis of essential oil showed that the number of identified compounds was 12, especially thymol and carvacrol (natural antioxidants). Senile male rats were fed on hypercholesterolemia diet (HCD) containing cholesterol (1% w/w) and sodium cholate (0.2% w/w). Twenty eight male rats were equally and randomly categorized into four groups. Rats of group (1) fed on balanced commercial diet, group (2) fed on high cholesterol diet for 8 weeks, groups (3) and (4) fed on high cholesterol diet supplemented with either raw or irradiated thyme (1% w/w) for 8 weeks. The results obtained revealed that rats fed on high cholesterol diet significantly showed increase in serum total lipids, TG, TC, LDL-C, VLDL-C as well as ratio risk, associated with remarkable decrease in HDL-C. A significant increase was observed in the level of lipid peroxidation (TBARS) associated with significant decrease in hepatic antioxidant enzymes (glutathion reductase; GSH and catalase; CAT) and total antioxidant capacity. Also, high cholesterol diet induced significant elevation in the level of glucose and liver enzymes (AST, ALT, ALP). The results obtained revealed that feeding rats on HCD containing either raw or irradiated thyme (1% w/w) induced significant improvement in the mentioned parameters. Also, the thyme suppressed lipid peroxidation

  3. The effects of music intervention on the emotion, haemodynamics and endocrine hormone level of senile patients during the perianesthesia period

    Directory of Open Access Journals (Sweden)

    Liang Feng

    2017-01-01

    Full Text Available Purpose: to explore the effects of music intervention on haemodynamics and endocrine hormone level of senile patients. Methods: choosing ASA II-III level and selecting 60 senile patients performed with intraspinal anesthesia; randomly dividing them into the intervention group and control group with 30 cases in each group. Both the two groups of patients completed the SAS before entering the operating room. When the patients of the intervention group entered the operating room, selected music would be played in a continuous loop immediately till the end of the operation while the doctors of the control group just told the patient to relax without music or other special treatment. Recording and comparing the SAS scores, SBP, HR and salivary cortisol concentration of the two groups before and after intervention. Results: the SAS scores, SBP, HR and salivary cortisol concentration of the intervention group were significantly decreased compared with the value before intervention and the differences within and between the groups were significant (P < 0.05. Conclusion: music intervention can effectively reduce the preoperative anxiety, ease intranperative tension and maintain the stability of hemodynamics, so it is beneficial for senile parents to live through the perianesthesia period.

  4. ALGORITHM OF DIAGNOSTICS AND TREATMENT OF ELDERLY AND SENILE PATIENTS WITH ACUTE CHOLECYSTITIS, CHOLEDOCHOLITHIASIS AND OBSTRUCTIVE JAUNDICE

    Directory of Open Access Journals (Sweden)

    M. D. Dibirov

    2017-01-01

    Full Text Available We performed a retrospective analysis of treatment in 4,197 patients with acute cholecystitis. Destructive complicated cholecystitis was diagnosed in 658 (25.3% patients . There were 431 (65.5% patients of elderly and senile age. All patients had comorbidities. Cardiovascular insufficiency — 73.9%, respiratory diseases — 29.2%, diabetes — 26%. For urgent indications, 12 (2.8% patients were operated, 2 (16.6% of them died. In 419 (97.2% patients, mini-invasive treatment was performed. Endoscopically, jaundice wasn’t managed in 86 (20.5% cases. In 62 (14.8% cases, percutaneous transhepatic microcholangiography was performed under ultrasound guidance. Laparoscopic cholecystectomy was performed in 183 (43.6 % cases, traditional cholecystectomy was performed in 149 (35.6% cases, and in 38 of them (23.9% it was combined with Kerr’s drainage of choledoch. Mini-invasive cholecystectomy was performed in 87 (20.7% cases. Postoperative complications were revealed in 21 (5.0% patients, in 7 (2.9% of elderly age and 14 (7.9% of senile age. Postoperative mortality rate was 2.0%. The use of minimally invasive interventions in the complex treatment of this group of patients was the main goal and it was reasoned by the severity of the initial condition of elderly and senile patients.

  5. The level of T lymphocyte subpopulation and cytokines in senile patients with stable chronic obstructive pulmonary disease

    International Nuclear Information System (INIS)

    Mu Xiaofen; Chen Sujuan; Cai Lili; Dong Ke

    2006-01-01

    To investigate the level of T-lymphocyte subsets(CD3 + , CD4 + , CD8 + )and serum IL-4, IL-8 and TNF-α in senile patients with stable chronic obstructive pulmonary disease(COPD) and provide basis in observing the inflammatory process of COPD, 50 senile patients with stable COPD and 40 senile healthy persons as control group were selected, and levels of IL-4, IL-8 and TNF-α in serum were detected by RIA method, the T-lymphocyte subset (CD3 + , CD4 + , CD8 + )of peripheral blood was measured by flow cytometry. The levels of CD3 + , CD4 + in COPD group were lower than in control group (P + IL-8 were also slightly higher in COPD group compared with that in control group, but the difference between them is not significant. CD3 + , CD4 + were lower and IL-4, TNF-α were higher in COPD group than those in control group, which means that abnormal cellular immunity function and inflammatory process still existed in the stable period of COPD. (authors)

  6. Relationships between automated EEG and cranial CT in patients with senile dementia

    International Nuclear Information System (INIS)

    Mori, Katsumi; Miyasaka, Mutue; Nakano, Takashi; Ohtaka, Tadashi

    1988-01-01

    The degree of dementia was examined in relation to findings of automated EEG and cranial CT in 50 demented old patients aged 51 - 86. Slow waves on EEC, and dilated ventricle and atrophied cortex on cranial CT were frequently associated with poor psychological scores. As the degree of dilated ventricle increased, the frequency and amplitude of slow waves increased and the frequency and continuity of α waves decreased. Dilated ventricle was more strongly correlated with abnormal EEG findings than atrophied cortex. This was more marked in cases of severer patients. Abnormal EEC findings associated with poor psychological scores were more frequently observed in the group of patients with vascular dementia (VD, n = 30) than the group of patients with senile dementia of Alzheimer type (SDAT, n = 20). Abnormal EEG findings were correlated with poor scores on Hasegawa test in the VD group and with those on Bender Gestalt test in the SDAT group. The degree of dilated ventricle was more correlated with abnormal EEG findings in the SDAT group than the VD group. (Namekawa, K.)

  7. Investigations on inorganic elements in human lenses of normal and senile cataractous character

    International Nuclear Information System (INIS)

    Oerdoegh, M.; Racz, P.

    1977-01-01

    Some essential trace elements as copper, zinc, iron, cobalt, scandium and rubidium have been measured by neutron activation analysis in normal and different types of senile cataractous lenses. Normal lenses were obtained from eyes enucleated because of tumours of the posterior pole and removed from cadaver eyes in 4 hrs after death. The cataractous lenses with intact capsule were removed by cryoextraction and immediately analysed. The single lenses were dried at 100 deg C to constant weight and always weighed before (wet weight) and after drying (dry weight). Unfortunately, because of the nuclear properties of the analysed elements not all of them could be determined in a single lense, thus three lenses were needed for the determination of eight elements. For the determination of manganese a single lens was irradiated for 6 min, then destroyed in a mixture of conc. sulphuric acid and conc. nitric acid. This was followed by a two-step chemical separation. For the analysis of copper the samples were irradiated for 1 hr, then destroyed as above and the copper was separated in the form of copper-thiocyanate. The long-lived isotopes were measured after 115 hrs irradiation and a cooling for 10 days without destruction of the sample. Tabulated data are given and the results are compared with literature data. (T.G.)

  8. Mouse senile amyloid fibrils deposited in skeletal muscle exhibit amyloidosis-enhancing activity.

    Directory of Open Access Journals (Sweden)

    Jinze Qian

    2010-05-01

    Full Text Available Amyloidosis describes a group of protein folding diseases in which amyloid proteins are abnormally deposited in organs and/or tissues as fine fibrils. Mouse senile amyloidosis is a disorder in which apolipoprotein A-II (apoA-II deposits as amyloid fibrils (AApoAII and can be transmitted from one animal to another both by the feces and milk excreted by mice with amyloidosis. Thus, mouse AApoAII amyloidosis has been demonstrated to be a "transmissible disease". In this study, to further characterize the transmissibility of amyloidosis, AApoAII amyloid fibrils were injected into transgenic Apoa2(cTg(+/- and normal R1.P1-Apoa2(c mice to induce AApoAII systemic amyloidosis. Two months later, AApoAII amyloid deposits were found in the skeletal muscles of amyloid-affected mice, primarily in the blood vessels and in the interstitial tissues surrounding muscle fibers. When amyloid fibrils extracted from the skeletal muscles were subjected to Western blot analysis, apoA-II was detected. Amyloid fibril fractions isolated from the muscles not only demonstrated the structure of amyloid fibrils but could also induce amyloidosis in young mice depending on its fibril conformation. These findings present a possible pathogenesis of amyloidosis: transmission of amyloid fibril conformation through muscle, and shed new light on the etiology involved in amyloid disorders.

  9. Relationships between automated EEG and cranial CT in patients with senile dementia

    Energy Technology Data Exchange (ETDEWEB)

    Mori, Katsumi; Miyasaka, Mutue; Nakano, Takashi; Ohtaka, Tadashi

    1988-08-01

    The degree of dementia was examined in relation to findings of automated EEG and cranial CT in 50 demented old patients aged 51 - 86. Slow waves on EEC, and dilated ventricle and atrophied cortex on cranial CT were frequently associated with poor psychological scores. As the degree of dilated ventricle increased, the frequency and amplitude of slow waves increased and the frequency and continuity of ..cap alpha.. waves decreased. Dilated ventricle was more strongly correlated with abnormal EEG findings than atrophied cortex. This was more marked in cases of severer patients. Abnormal EEC findings associated with poor psychological scores were more frequently observed in the group of patients with vascular dementia (VD, n = 30) than the group of patients with senile dementia of Alzheimer type (SDAT, n = 20). Abnormal EEG findings were correlated with poor scores on Hasegawa test in the VD group and with those on Bender Gestalt test in the SDAT group. The degree of dilated ventricle was more correlated with abnormal EEG findings in the SDAT group than the VD group. (Namekawa, K.).

  10. Senile dementia of the Binswanger type: a vascular form of dementia in the elderly

    International Nuclear Information System (INIS)

    Roman, G.C.

    1987-01-01

    Computed tomography and magnetic resonance imaging in the elderly have demonstrated the common occurrence of deep white-matter lesions in the aging brain. These radiologic lesions (leukoaraiosis) may represent an early marker of dementia. At autopsy, an ischemic periventricular leukoencephalopathy (Binswanger's disease) has been found in most cases. The clinical spectrum of Binswanger's disease appears to range from asymptomatic radiologic lesions to dementia with focal deficits, frontal signs, pseudobulbar palsy, gait difficulties, and urinary incontinence. The name senile dementia of the Binswanger type (SDBT) is proposed for this poorly recognized, vascular form of subcortical dementia. The SDBT probably results from cortical disconnections most likely caused by hypoperfusion. In contrast, multi-infarct dementia is correlated with multiple large and small strokes that cause a loss of over 50 to 100 mL of brain volume. The periventricular white matter is a watershed area irrigated by long, penetrating medullary arteries. Risk factors for SDBT are small-artery diseases, such as hypertension and amyloid angiopathy, impaired autoregulation of cerebral blood flow in the elderly, and periventricular hypoperfusion due to cardiac failure, arrhythmias, and hypotension. The SDBT may be a potentially preventable and treatable form of dementia

  11. Regional cerebral blood flow and brain atrophy in senile dementia of Alzheimer type (SDAT)

    International Nuclear Information System (INIS)

    Okada, Kazunori; Kobayashi, Shoutai; Yamaguchi, Shuhei; Kitani, Mituhiro; Tsunematsu, Tokugoro

    1987-01-01

    To investigate the relationship between the reduction of cerebal blood flow and brain atrophy in SDAT, these were measured in 13 cases of senile dementia of Alzheimer type, and compared to 15 cases of multi-infarct Dementia, 39 cases of lacunar infarction without dementia (non-demented CVD group) and 69 cases of aged normal control. Brain atrophy was evaluated by two-dimensional method on CT film by digitizer and regional cerebral blood flow (rCBF) was measured by 133 Xe inhalation method. The degree of brain atrophy in SDAT was almost similar of that of MID. But it was more severe than that of non-demented group. MID showed the lowest rCBF among these groups. SDAT showed significantly lower rCBF than that of aged control, but rCBF in SDAT was equal to that of lacunar stroke without dementia. Focal reduction of cerebral blood flow in bilateral fronto-parietal and left occipital regions were observed in SDAT. Verbal intelligence score (Hasegawa's score) correlated with rCBF and brain atrophy index in MID, and a tendency of correlation between rCBF and brain atrophy in MID was also observed. However, there was no correlation among those indices in SDAT. These findings suggest that the loss of brain substance dose not correspond to the reduction of rCBF in SDAT and simultaneous measurement of rCBF and brain atrophy was useful to differ SDAT from MID. (author)

  12. The clinical diagnosis and misdiagnosis of senile dementia of Lewy body type (SDLT).

    Science.gov (United States)

    McKeith, I G; Fairbairn, A F; Perry, R H; Thompson, P

    1994-09-01

    Current clinical classifications do not contain specific diagnostic categories for patients with senile dementia of the Lewy body type (SDLT), recently proposed as the second commonest neuropathological cause of dementia in the elderly. This study determines how existing clinical diagnosis systems label SDLT patients and suggests how such patients may be identified. A range of clinical diagnostic criteria for dementia were applied to case notes of autopsy-confirmed SDLT (n = 20), dementia of Alzheimer type (DAT; n = 21) and multi-infarct dementia (MID; n = 9) patients who had received psychogeriatric assessment. The predictive validity of each set of clinical criteria was calculated against the external criterion of neuropathological diagnosis. Many SDLT patients erroneously met criteria for MID (35% with Hachinski scores > or = 7) or for DAT (15% by NINCDS 'probable AD', 35% by DSM-III-R DAT and 50% by NINCDS 'possible AD'). Up to 85% of SDLT cases could be correctly identified using recently published specific criteria. SDLT usually has a discernible clinical syndrome and existing clinical classifications may need revision to diagnose correctly such patients.

  13. Progressive senile scoliosis: Seven cases of increasing spinal curves in elderly patients

    Energy Technology Data Exchange (ETDEWEB)

    Gillespy, T. III; Gillespy, T. Jr.; Revak, C.S.

    1985-04-01

    An increasing scoliosis was documented in seven elderly women. The average curve at the most recent examination was 43/sup 0/ (range 26/sup 0/-78/sup 0/). Previous films, from 5 to 26 years before, demonstrated an average increase of 2.3/sup 0//year (range 1/sup 0/-4.8/sup 0//year). There were three lumbar and four thoracolumbar curves. Three curves were to the right and four were to the left. Only one patient had osteoporotic vertebral body crush fractures. The common underlying mechanism in the progression of senile scoliosis appears to be asymmetric loading of the spine which can be caused by a previously established scoliosis, spondylolysis/spondylolisthesis, lumbosacral anomalies, or leg length discrepancy. Subsequently, factors that can cause a curve to increase include degenerative disc disease with lateral disc space narrowing, soft tissue failure, and osteoporosis. Since even minor scoliosis can potentially progress in the older adult, increased monitoring of scoliosis in patients over age 50 years may be warranted.

  14. Progressive senile scoliosis: Seven cases of increasing spinal curves in elderly patients

    International Nuclear Information System (INIS)

    Gillespy, T. III; Revak, C.S.

    1985-01-01

    An increasing scoliosis was documented in seven elderly women. The average curve at the most recent examination was 43 0 (range 26 0 -78 0 ). Previous films, from 5 to 26 years before, demonstrated an average increase of 2.3 0 /year (range 1 0 -4.8 0 /year). There were three lumbar and four thoracolumbar curves. Three curves were to the right and four were to the left. Only one patient had osteoporotic vertebral body crush fractures. The common underlying mechanism in the progression of senile scoliosis appears to be asymmetric loading of the spine which can be caused by a previously established scoliosis, spondylolysis/spondylolisthesis, lumbosacral anomalies, or leg length discrepancy. Subsequently, factors that can cause a curve to increase include degenerative disc disease with lateral disc space narrowing, soft tissue failure, and osteoporosis. Since even minor scoliosis can potentially progress in the older adult, increased monitoring of scoliosis in patients over age 50 years may be warranted. (orig.)

  15. Spectral analysis and comparison of mineral deposits forming in opacified intraocular lens and senile cataractous lens

    Science.gov (United States)

    Lin, Shan-Yang; Chen, Ko-Hwa; Lin, Chih-Cheng; Cheng, Wen-Ting; Li, Mei-Jane

    2010-10-01

    This preliminary report was attempted to compare the chemical components of mineral deposits on the surfaces of an opacified intraocular lens (IOL) and a calcified senile cataractous lens (SCL) by vibrational spectral diagnosis. An opacified intraocular lens (IOL) was obtained from a 65-year-old male patient who had a significant decrease in visual acuity 2-years after an ocular IOL implantation. Another SCL with grayish white calcified plaque on the subcapsular cortex was isolated from a 79-year-old male patient with complicated cataract after cataract surgery. Optical light microscope was used to observe both samples and gross pictures were taken. Fourier transform infrared (FT-IR) and Raman microspectroscopic techniques were employed to analyze the calcified deposits. The curve-fitting algorithm using the Gaussian function was also used to quantitatively estimate the chemical components in each deposit. The preliminary results of spectral diagnosis indicate that the opacified IOL mainly consisted of the poorly crystalline, immature non-stoichiometric hydroxyapatite (HA) with higher content of type B carbonated apatites. However, the calcified plaque deposited on the SCL was comprised of a mature crystalline stoichiometric HA having higher contents of type A and type B carbonate apatites. More case studies should be examined in future.

  16. Quantitative neuropathological study of Alzheimer-type pathology in the hippocampus: comparison of senile dementia of Alzheimer type, senile dementia of Lewy body type, Parkinson's disease and non-demented elderly control patients.

    Science.gov (United States)

    Ince, P; Irving, D; MacArthur, F; Perry, R H

    1991-12-01

    A Lewy body dementing syndrome in the elderly has been recently described and designated senile dementia of Lewy body type (SDLT) on the basis of a distinct clinicopathological profile. The pathological changes seen in SDLT include the presence of cortical Lewy bodies (LB) frequently, but not invariably, associated with senile plaque (SP) formation. Whilst neocortical neurofibrillary tangles (NFT) are sparse or absent, a proportion of these cases show involvement of the temporal archicortex by lesions comprising Alzheimer-type pathology (ATP, i.e. NFT, SP and granulovacuolar degeneration [GVD]). Thus the relationship between SDLT and senile dementia of Alzheimer type (SDAT) is complex and controversial. In this study quantitative neuropathology was used to compare the intensity and distribution of ATP in the hippocampus and entorhinal cortex of 53 patients from 3 disease groups (SDLT, SDAT, Parkinson's disease (PD)) and a group of neurologically and mentally normal elderly control patients. For most brain areas examined the extent of ATP between the patient groups followed the trend SDAT greater than SDLT greater than PD greater than control. Statistical comparison of these groups revealed significant differences between the mean densities of NFT, SP and GVD although individual cases showed considerable variability. These results confirm additional pathological differences between SDAT and SDLT regarding the intensity of involvement of the temporal archicortex by ATP. Many patients with Lewy body disorders (LBdis) show a predisposition to develop ATP albeit in a more restricted distribution (e.g. low or absent neocortical NFT) and at lower densities than is found in SDAT. Some cases of SDLT show minimal SP and NFT formation in both neocortex and archicortex supporting previously published data distinguishing this group from Alzheimer's disease.

  17. Comparison of Apraxia between Patients with Senile Dementia of Alzheimer Type and Normal Aged People

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    Fariba Yadegari

    2007-07-01

    Full Text Available Objective: In addition to memory deficits and aphasia, many patients with Alzheimer’s disease (AD are apraxic which may bring about disturbances in their daily living. The purpose of present study was investigating the presence of any apraxic disorder in patients with senile dementia of Alzheimer type (SDAT and comparison with normal aged people. Materials & Methods: In this case–control and analytical study 14 SDAT patients were compared with 20 normal ageing people that they were matched with patients according to age and education. Patients were selected from Iranian Alzheimer Association clients with psychiatrist diagnostic confirmation and MMSE scores between 15-27 and compared with controls with MMSE scores between 25-30. Apraxia Test was administered on both groups. The Test included 4 subtests: conceptual movements gestured conceptual movements, oral and respiratory movements & pantomime of movements of object manipulations. Data was analyzed by using Kolmogoroff – Smirnoff test, Man – Witney, T-test for independent groups and pearsonian correlation coefficient. Results: Findings showed that apraxia scores were significantly (P<0/001 different between groups so that (SDAT patients were diagnosed as apraxic and controls were not. Besides, comparison of subtests scores of (SDAT patients revealed that conceptual movements scores were significantly (P<0/001 less than the other subtests (more apraxic and oral and respiratory movements scores were significantly (P<0/001 higher than the other subtests (less apraxic. Conclusion: Apraxia could be considered as one of the neuropsychological signs early in the disease development. It can be applied complementarily for differential diagnosis. Also apraxia subgroup scoring could be used for apraxia categorization, understanding observed disorders and determining possible rehabilitation ways.

  18. Apendicitis aguda en el paciente senil: Factores asociados a una mayor morbimortalidad post operatoria

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    Víctor Eduardo Chian Chang

    1996-04-01

    Full Text Available Objetivo: Definir los factores asociados a una mayor morbilidad y mortalidad en pacientes seniles con apendicitis aguda. Material y métodos: Se realizó un estudio retrospectivo con 100 pacientes intervenidos en el Hospital Nacional Arzobispo Loayza, durante el período comprendido entre 1984 a 1994. Resultados: Se asociaron a una mayor frecuencia de complicaciones postoperatorias: edad mayor o igual a 70 años, tiempo de enfermedad mayor de 48 horas, presencia de apendicitis perforada con peritonitis localizada o generalizada (p<0.05. Además la presencia de apendicitis perforada se asoció significativamente a la presencia de absceso residual y/o fístula estercorácea (p=0.027 y la presencia de AA gangrenosa o perforada a mayor frecuencia de infección de herida operatoria (p<0.05. El antecedente de patología cardiovascular previa se asoció a mayor frecuencia de complicaciones cardiovasculares (p<0.05. Se asociaron a mayor mortalidad en AA, pacientes con intervención quirúrgica adicional a la apendicetomía (p=0.016 y presencia de AA perforada (p=0.027. Conclusiones: Los estadios avanzados de AA, así como la presencia de problema cardiovascular al momento del diagnóstico se asociaron con una mayor frecuencia de complicaciones post-operatorias. La presencia de peritonitis se asocia con la mortalidad. (Rev Med Hered 1996; 7: 62-67.

  19. Characterization of Proteins Present in Isolated Senile Plaques from Alzheimer's Diseased Brains by MALDI-TOF MS with MS/MS.

    Science.gov (United States)

    Kelley, Andrea R; Perry, George; Bach, Stephan B H

    2018-04-18

    The increase of insoluble senile plaques in the brain is a primary hallmark of Alzheimer's disease. The usefulness of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) with tandem MS for the characterization of senile plaques from AD brains and the relevance of the components identified to furthering AD research using MS is discussed. Thirty-three components were reproducibly observed within tryptic aliquots of senile plaques from two different AD brains after sample preparation optimization. Additionally, this is one of the first accounts of LIFT being utilized for the direct sequencing of peptides from isolated senile plaques. While many of the species observed coisolated within senile plaques have been linked to AD etiology, if only speculatively, this is the first instance that many of them have been demonstrated to be a part of the plaques themselves. This work is the first step in determining the potential roles that the species may have in the aggregation or proliferation of the plaques.

  20. Globular bodies: a primary cause of the opacity in senile and diabetic posterior cortical subcapsular cataracts?

    Science.gov (United States)

    Creighton, M O; Trevithick, J R; Mousa, G Y; Percy, D H; McKinna, A J; Dyson, C; Maisel, H; Bradley, R

    1978-07-01

    We examined 9 cataracts from maturity onset diabetics and 4 senile posterior subcapsular cataracts by scanning electron microscopy, transmission electron microscopy, immunofluorescence for crystallin proteins and actin, histochemical methods and x-ray diffraction. The cataractous regions contained spherical globules up to 20 mu in diameter, often in a fibrous matrix. Some were extracellular Morgagnian globules, apparently formed by blebbing from the cell surface; others appeared to have been formed intracellularly. The area of globular degeneration was usually 300 mu deep, but had deeper fusiform extensions. Morphological changes in the cell cytoplasm varied according to their depth in the cataract. Electron microscopy showed intracellular and extracellular globules, many of them were bounded by lipid bilayer membranes. Immunofluorescent staining showed that all the globules contained gamma-crystallin; some contained alpha- and beta-crystallins and actin. All the globules contained higher concentrations of cysteine or cystine than the surrounding lens tissue but they did not react to stains for carbohydrate or calcium. X-ray diffraction studies showed that crystalline calcium salts were absent. Globules and cavities averaged 45% of the total area in cross section. Assuming an area of cataract to be 300 micron thick and that globules 1 mu in diameter scattered, while 2--20 mu in diameter reflected light, we calculated that light passing through such a thickness would be reduced by 65%. Thus the globules could account for most of the opacity of the cataractous area. Presumably the fibrous degeneration of the cells causes enough light scattering to account for the remainder of the reduction. Cataract patients complain of decreased visual acuity, a golden halo around objects, and difficulties when driving while facing oncoming traffic at night. These probably result from light scattering. In our previous experiments, globular bodies containing gamma-crystallin were

  1. Abnormally phosphorylated tau protein in senile dementia of Lewy body type and Alzheimer disease: evidence that the disorders are distinct.

    Science.gov (United States)

    Strong, C; Anderton, B H; Perry, R H; Perry, E K; Ince, P G; Lovestone, S

    1995-01-01

    The relationship between Alzheimer disease (AD) and dementia with Lewy bodies (senile dementia Lewy body type, or SDLT) and dementia in Parkinson's disease is unclear. AD pathology is characterised by both amyloid deposition and abnormal phosphorylation of tau in paired helical filaments (PHF-tau). In AD, abnormally phosphorylated PHF-tau is present in neurofibrillary tangles, in neuritic processes of senile plaques, and also in neuropil threads dispersed throughout the cerebral cortex. Cortical homogenates from 12 cases each of AD and SDLT, 13 cases of Parkinson's disease, and 11 normal controls were examined by Western blot analysis with antibodies that detect PHF-tau. No PHF-tau was found in Parkinson's disease or control cortex. No PHF-tau was found in SDLT cases without histological evidence of tangles. PHF-tau was detectable in SDLT cases with a low density of tangles, and large amounts of PHF-tau were present in AD cases. This study demonstrates that abnormally phosphorylated PHF-tau is only present where tangles are found and not in SDLT cases without tangles or with only occasional tangles. It is concluded that Lewy body dementias are distinct at a molecular level from AD.

  2. 老年骨质疏松性骨折的康复治疗%Rehabilitative treatment of senile osteoporosis fracture

    Institute of Scientific and Technical Information of China (English)

    王兵

    2003-01-01

    @@ When the senile patients with osteoporosis fracture are hospitalized,fracture is cured by surgical department of orthopedics and osteoporosis is cured by internal department of orthopedics,which is timely and appropriate.Even after union of fracture,the comprehensive treatment is essential for such patients.

  3. A randomized, placebo-controlled, double-blind study to evaluate the efficacy of a citrus bioflavanoid blend in the treatment of senile purpura.

    Science.gov (United States)

    Berlin, Joshua M; Eisenberg, David P; Berlin, Mindy B; Sarro, Robert A; Leeman, Douglas R; Fein, Howard

    2011-07-01

    Senile purpura is a common, chronic skin condition affecting more than 10 percent of individuals over the age of 50. Despite being a benign condition, the continual development of purpura lesions in afflicted patients is frequently a source of significant visual and social concern. To date, there are no known effective treatments for this condition. To evaluate the efficacy of a novel nutraceutical citrus bioflavonoid blend in improving the skin's appearance in patients with senile purpura. A six-week, randomized, multicenter, placebo-controlled, double-blind study was conducted to determine whether a uniquely formulated, oral citrus bioflavonoid supplement could treat active lesions of senile purpura while preventing new lesions from arising. Seventy patients with senile purpura were enrolled and 67 completed the study. Subjects were randomized into two groups receiving either a citrus bioflavonoid blend or placebo medication, which was taken orally twice daily for six weeks. Clinical evaluations were performed by blinded investigators at two locations. A statistically significant reduction in the number of new purpura lesions in the skin area undergoing clinical study was documented. At the end of six weeks, the citrus bioflavonoid blend treated group showed a 50 percent reduction in purpura lesions from baseline. Patient self-assessment of the effectiveness of the medication echoed the results of an investigator global assessment with a statistically significant improvement in the skin's appearance noted by the patients receiving the active medication. No adverse effects were noted by either the patients or investigators. This new treatment appears to both safely and effectively diminish skin bruising in patients with senile purpura.

  4. Synapsin I (Protein I) in different brain regions in senile dementia of Alzheimer type and in multiinfarct dementia. [Radioimmunoassay

    Energy Technology Data Exchange (ETDEWEB)

    Adolfsson, R; Alafuzoff, I; Winblad, B [Umeaa Univ. (Sweden); Perdahl, E; Albert, K A; Nestler, E J; Greengard, P [Rockefeller Univ., New York (USA)

    1984-01-01

    Synapsin I (Protein I), a neuron-specfic phosphoprotein enriched in presynaptic nerve terminals, has been used as a quantitative marker for the density of nerve terminals in five brain regions (caudate nucleus, cingulate gyrus, hippocampus, mesencephalon and putamen) from patients who had suffered from Alzheimer disease/senile dementia of Alzheimer type (AD/SDAT), from patients with multi-infarct dementia (MID), and from agematched controls. Samples were obtained at autopsy. Lower levels of Synapsin I were observed in the hippocampus of patients with AD/SDAT but not with MID. There were no significant differences in Synapsin I levels between patients and controls in any of the other four brain regions examined.

  5. Synapsin I (protein I) in different brain regions in senile dementia of Alzheimer type and in multiinfarct dementia

    International Nuclear Information System (INIS)

    Adolfsson, R.; Alafuzoff, I.; Winblad, B.; Perdahl, E.; Albert, K.A.; Nestler, E.J.; Greengard, P.

    1984-01-01

    Synapsin I (Protein I), a neuron-specfic phosphoprotein enriched in presynaptic nerve terminals, has been used as a quantitative marker for the density of nerve terminals in five brain regions (caudate nucleus, cingulate gyrus, hippocampus, mesencephalon and putamen) from patients who had suffered from Alzheimer disease/senile dementia of Alzheimer type (AD/SDAT), from patients with multi-infarct dementia (MID), and from agematched controls. Samples were obtained at autopsy. Lower levels of Synapsin I were observed in the hippocampus of patients with AD/SDAT but not with MID. There were no significant differences in Synapsin I levels between patients and controls in any of the other four brain regions examined. (Author)

  6. Effects of apolipoprotein E genotype on cortical neuropathology in senile dementia of the Lewy body and Alzheimer's disease.

    Science.gov (United States)

    Benjamin, R; Leake, A; Ince, P G; Perry, R H; McKeith, I G; Edwardson, J A; Morris, C M

    1995-12-01

    Apolipoprotein E (APO E) genotypes were determined in a UK population of neuropathologically confirmed control cases, and in cases of Lewy body dementia (SDLT) and late onset Alzheimer's disease (AD). APO E epsilon 4 allele frequency was significantly elevated in both SDLT and AD groups with a concomitant reduction in the APO E epsilon 3 allele frequency. The epsilon 2 allele frequency in the AD group was only 25% of the control population, though because of the relatively small sample size this reduction was not significant; the epsilon 2 allele frequency in the SDLT group was normal. No significant association was found between senile plaque density and neurofibrillary tangle density in the neocortex and APO E allele dose in either SDLT or AD. Although the possession of APO E epsilon 4 is associated with an increased risk of developing SDLT and AD, actual APO E genotype does not appear to affect the burden of pathology.

  7. [Association between metabolic syndrome and the 10 years mortality of cerebro-cardiovascular diseases in the senile population].

    Science.gov (United States)

    Jin, Meng-meng; Pan, Chang-Yu; Tian, Hui; Liu, Min; Su, Hai-yan

    2008-02-01

    To assess the prevalence of metabolic syndrome (MS) and its association with mortality of cerebro-cardiovascular diseases in senile population. Data were collected from 1926 people aged 60 and over, who took part in routine health examination in our hospital from 1996 to 1997. All subjects were followed up for 10 years. MS was diagnosed by using the definition recommended by Chinese Diabetic Society in 2004. Cox-proportional hazards models were used in survival analyses and to calculate the relative risk (RR) of cerebro-cardiovascular diseases mortality. The prevalence of MS was 25.03% (n = 482, Group 2) in this population. The 10 year mortality of cerebro-cardiovascular diseases was significantly higher (6.82/1000-person year vs. 2.55/1000-person year, P cerebro-cardiovascular diseases mortality was 2.52 (95% CI 1.367 - 4.661, P cerebro-cardiovascular diseases.

  8. Peculiarity of A-bomb cataract complicated by incipient senile cataract-report of 2 recent cases

    Energy Technology Data Exchange (ETDEWEB)

    Sugimoto, S [Sugimoto Ophthalmic Clinic, Hiroshima (Japan)

    1980-03-01

    Two cases of typical cataract caused by atomic bomb radiation were observed. Both patients were male and had been exposed near the hypocenter (950m and 140m from the hypocenter) when they were young (12 years and 5 months, and 15 years and 3 months). Wounds at the exposure were not fatal, but their exposure doses were close to the lethal dose (570 and 609 rad). Their acute symptoms were severe. Nevertheless, their symptoms recovered by rest and good nutrition. Lenticular opacities (delayed ocular damage caused by atomic radiation) occurred in one patient 3 years and 7 months after the exposure and in the other patient 4 years after the exposure. It was 33 years and 10 month after the exposure when both patients aged 45 and 48 had senile cataract. Effects of aging on both patients exposed to large doses of radiation in young ages were suggested.

  9. A MULTIDISCIPLINARY APPROACH IN THE TREATMENT OF FRACTURES OF THE PROXIMAL FEMUR ON THE BACKGROUND OF SENILE OSTEOPOROSIS

    Directory of Open Access Journals (Sweden)

    N. V. Zagorodniy

    2016-01-01

    Full Text Available The article presents a review of published data on the problem of osteoporosis in patients older than 75 years who have had fractures of the proximal femur. We used descriptive and analytical methods. Search publications have done in accessible to free search databases. Based on our analysis, it was found: the majority of researchers in Russia and abroad are united in the opinion that this issue requires a multidisciplinary approach; surgical treatment should be initiated as early as possible after the onset of fracture, before the complications from side of the internal organs; patients with fractures on the background of senile osteoporosis should receive drugs that affect to the quantitative and qualitative components of bone.

  10. THE USAGE OF ORIGINAL COMPUTER PROGRAM FOR SCREENING OF SENILE ASTHENIA IN PRE- AND POST GRADUATE MEDICAL EDUCATION

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    Svetlana G. Gorelik

    2014-02-01

    Full Text Available The results of introduction of information technologies in educational process of medical students and students of postgraduate education were shown in the article. The actuality of material, which was outlined in the article, was caused by problems, which prevailed in the system of high education and by necessity of cooperation between practical health care and theoretical knowledge. For this aim the original «Computer program of optimization of care in geriatrics in dependence from degree of senile asthenia” was proposed. This program solved not only problems of qualitative alteration of informative environment of educational system but it contributed to increasing of effectiveness of knowledge’s mastering for increasing the quality of medical and social help to population.

  11. TREATMENT OUTCOMES IN ELDERLY AND SENILE PATIENTS WITH DEGENERATIVE DEFORMATIONS AND INSTABILITY OF THE SPINAL COLUMN

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    D. A. Mikhaylov

    2017-01-01

    Full Text Available Degenerative  scoliosis  is  a  prevalent  issue  among  the  aging  population.  Controversy  remains   over  the  role of surgical intervention in patients with such disease. The authors  present  the results of 14-year experience in treatment of this pathology.  Various approaches  to the surgical treatment depending  on the stage of the disease and the degree of deformation, including  decompression, instrumental posterior spinal fusion, anterior spinal fusion, and osteotomy were examined. Above treatment options are based on the analysis of clinical aspects, mechanical  stability of deformation, the degree of imbalance in the body and causes of pain or neurological  deficit.The  risk of postoperative complications is extremely  high and seems to be outweighed by the  possible successful outcomes of surgical treatment. The results presented in the treatment of degenerative scoliosis mainly provide positive outcomes and can assist in the selection of treatment for this group of patients.The purpose of the  study  is to  evaluate  the  treatment outcomes  of elderly  and  senile patients with  degenerative deformations and instability of the spinal column using various surgical techniques.Material and methods. During  the present  retrospective study the authors  analyzed 437 patients (337 (77% women and  100  (23%  men  aged  60 years  and  older  who  underwent surgical  treatment at  Russian  Research  institute of traumatology and orthopaedics named  after  R.R.Vreden between  2000 and 2016. The  study  group  included  patients with  diseases and consequences  of injuries  in the  spine, leading  to its deformation and following spinal stenosis  with development of neurological  deficit in some cases.The  patients were subdivided into  four  groups  depending  on surgical  procedure.  Patients in group  I underwent decompression  of neural  structures at affected

  12. Neocortical concentrations of neuropeptides in senile dementia of the Alzheimer and Lewy body type: comparison with Parkinson's disease and severity correlations.

    Science.gov (United States)

    Leake, A; Perry, E K; Perry, R H; Jabeen, S; Fairbairn, A F; McKeith, I G; Ferrier, I N

    1991-02-15

    Corticotropin releasing hormone (CRH), somatostatin (SRIF), and arginine vasopressin (AVP) concentrations were estimated using radioimmunoassay in the temporal and occipital cortices in postmortem brain from patients clinically and neuropathologically diagnosed as senile dementia of the Lewy body type (SDLT), senile dementia of the Alzheimer type (SDAT), and Parkinson's disease (PD) and from neurologically normal controls. The concentration of temporal and occipital neocortical CRH was diminished in both SDAT and SDLT compared to control values, whereas SRIF was reduced only in temporal cortex in both these conditions. In contrast, the concentrations of both CRH and SRIF were unaltered in PD. The concentrations of AVP in SDLT, SDAT, and PD were similar to those found in the control groups. The decrement in SRIF, but not CRH, was found to be correlated with some indices of severity of illness in SDAT; a similar but nonsignificant trend for SRIF was observed in SDLT.

  13. Influence of apolipoprotein E genotype on senile dementia of the Alzheimer and Lewy body types. Significance for etiological theories of Alzheimer's disease.

    OpenAIRE

    Harrington, C. R.; Louwagie, J.; Rossau, R.; Vanmechelen, E.; Perry, R. H.; Perry, E. K.; Xuereb, J. H.; Roth, M.; Wischik, C. M.

    1994-01-01

    Alzheimer's disease (AD) is associated with an increased frequency of the apolipoprotein E type epsilon 4 allele. To address both the disease and the allele specificity of this association, we have examined the apolipoprotein E allele distribution in 255 elderly persons including those with autopsy-confirmed AD, senile dementia of the Lewy body type (SDLT), vascular dementia, Parkinson's disease (PD) or Huntington's disease and in nondemented controls either with or without coronary complicat...

  14. Fouling community dominated by Metridium senile (Cnidaria: Anthozoa: Actiniaria in Bahía San Julián (southern Patagonia, Argentina

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    Juan Pablo Martin

    2015-06-01

    Full Text Available The objective of this study is to provide information about a harbour-fouling community dominated by Metridium senile in southern Patagonia. Several steel tubes from the wharf of Puerto San Julián were extracted to perform repair tasks, allowing the attached benthic community to be studied. Sampling was conducted at three levels: lower intertidal, 3-4 m depth and 6-7 m depth. In the lower intertidal, M. senile had a relative abundance of 43%, the most abundant accompanying species being Perumytilus purpuratus, Mytilus edulis platensis and Aulacomya atra atra. At subtidal level, the anemone showed relative abundances of 64% and 65%, and was accompanied by Monocorophium insidiosum at 3-4 m depth and by polychaetes of families Sabellidae and Syllidae at 6-7 m at depth. In the lower intertidal, epibiosis was more frequent on P. purpuratus, A. atra atra and M. edulis platensis, while in the subtidal, the richness of substrate-organisms increased significantly and the anemone was fixed to A. atra atra, M. edulis platensis, Paramolgula gregaria, Crepipatella dilatata, Austromegabalanus psittacus, Hiatella arctica, Polyzoa opuntia, Pyura sp. and Sabellidae tubes. The ability of M. senile to settle on many different organisms, along with other strategies, makes it a colonizer able to displace other species that could compete with it for substratum. Given the cosmopolitan nature of M. senile, the fact that this species has not been previously reported in the coastal zone of the region, and the results of our study, we discuss the possibility that this sea anemone is an invasive alien species in southern Patagonia, or at least a cryptogenic species.

  15. LONG-TERM THERAPY WITH INDAPAMIDE IN ELDERLY AND SENILE PATIENTS WITH HYPERTENSION: CARDIORENOPROTECTIVE EFFECTS AND INFLUENCE ON QUALITY OF LIFE

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    M. E. Statsenko

    2009-01-01

    Full Text Available Aim. To estimate cardiorenoprotective effect of 12-month therapy by indapamide in elderly and senile patients with arterial hypertension (HT and its influence on quality of life.Material and methods. 40 elderly and senile patients with HT were examined. 70% of patients received monotherapy by indapamide 2,5 mg once daily and 30% of patients were treated with indapamide and lisinopril combination. Duration of observation was 12 months. Ambulatory blood pressure (BP monitoring, echocardiography, plasma lipid profile, glycemia and uricemia levels and potassium serum level was evaluated initially and after 12 months of therapy. Glomerular filtration rate and albuminuria as well as patient quality of life also was evaluated.Results. Target BP level was reached in all patients during 12 month therapy. Reduction of average 24-hour, day and night BP, BP load, rate of morning BP rising was observed. Negative influence on BP variability was not found. Improvement of daily BP profile also was found. The indapamide reduced left ventricle mass, improved renal function, vessel resistance and quality of life. Negative influence of long-term therapy with indapamide on lipid, glucose, purine metabolism and serum potassium level was not observed.Conclusion. Indapamide is an effective antihypertensive drug for long-term treatment of elderly and senile patients with HT of 1-2 degree.

  16. Técnica de Blumenthal en el tratamiento de la catarata senil en el Centro Oftalmológico "Machala-Cuba" Ecuador

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    Bárbara Teresa Soler Quintana

    Full Text Available Objetivo: determinar los resultados de la aplicación de la técnica quirúrgica de Blumenthal en el tratamiento de la catarata senil. Métodos: se realizó un estudio descriptivo, longitudinal y prospectivo en el Centro Oftalmológico "Machala-Cuba", en Ecuador, durante el año 2010. El universo estuvo constituido por 800 ojos con diagnóstico de catarata senil. Se seleccionó una muestra de 200 ojos mediante muestreo aleatorio simple. En la recogida de los datos se expusieron todas las variables de interés de la investigación como edad y sexo, agudeza visual preoperatoria y posoperatoria, técnica anestésica empleada, percepción del dolor y complicaciones transoperatorias más frecuentes. Los datos fueron procesados y analizados mediante técnicas estadísticas descriptivas y porcentuales. Resultados: predominó el sexo femenino y el grupo de edad de 80 años o más. El mayor porcentaje de los pacientes refirió percepción leve del dolor con el uso de la anestesia epibulbar. Se observaron pocas complicaciones y una buena agudeza visual posquirúrgica. Conclusiones: la aplicación de la técnica de Blumenthal tiene buenos resultados en los pacientes operados de catarata senil.

  17. Comparative study on the 3H-thymidine index of dorsal epidermis, buccal mucosa, and seminal vesicles in senile male rats

    International Nuclear Information System (INIS)

    Hornstein, O.P.; Schell, H.

    1975-01-01

    To supplement previous investigations on endogenous fluctuations of DNA synthesis in male rat dorsal epidermis, buccal mucosa and seminal vesicle epithelium from birth to sexual maturity, the labelling indices (L.I.) of these tissues in senile male rats from the same breed, studied under analogous experimental conditions, were evaluated as well as compared to the data obtained from rats in puberal and early mature age. In the dorsal epidermis and buccal mucosa of the old animals the medium L.I. were found to be at about the same level as those measured after puberty. In the aged seminal vesicle epithelium the medium L.I. was found to be decreased. The maintenance of epidermal and buccal DNA synthesis in senile rats as well as the results of previous studies with male rats subjected to castration or long-term administration of cyproteron acetate furnish evidence that a deficiency of testosteron does not diminish the rate of DNA synthesis in epidermis and buccal mucosa. However, from the decreased L.I. in seminal vesicle epithelium a reduced blood level or stimulating capacity, respectively, of testosteron in senile rats can be concluded. Furhtermore, withdrawal of testosteron by orchidectomy or administration of cyproteron acetate is appropriate to suppress significantly the proliferative activity of seminal vesicles epithelium. (orig.) [de

  18. Effect of milrinone on the cardiac function and N-terminal pro-brain natriuretic peptide levels in patients with senile refractory heart failure

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    Jiao-Na Wei1

    2017-06-01

    Full Text Available Objective: To study the effect of milrinone on the cardiac function and N-terminal probrain natriuretic peptide (NT-proBNP levels in patients with senile refractory heart failure. Methods: 90 patients with senile refractory heart failure who were treated in our hospital between August 2013 and August 2016 were collected and divided into control group (n=45 and observation group (n=45 according to the random number table. The control group received regular clinical treatment, and the observation group received regular + milrinone treatment. The cardiac function and serum NT-proBN contents were compared between two groups of patients before and after treatment. Results: Before treatment, the differences in ultrasound and serum cardiac function indexes and serum NT-proBN levels were not statistically significant between two groups of patients. After treatment, ultrasound serum cardiac function parameter LVEDD level in observation group was lower than that in control group while CI and SV levels were higher than those in control group; serum cardiac function indexes Cys-C, GDF-15, sST2 and H-FABP contents were lower than those in control group; serum NT-proBNP content was lower than that in control group. Conclusion: Milrinone therapy can optimize the cardiac function and reduce the serum NT-proBN levels in patients with senile refractory heart failure.

  19. Descrição da qualidade vocal de personagens idosos dos filmes de Hollywood Vocal quality description of senile characters from Hollywood movies

    Directory of Open Access Journals (Sweden)

    Gisele Oliveira

    2010-06-01

    Full Text Available OBJETIVO: descrever a qualidade vocal de personagens idosos dos filmes de Hollywood. MÉTODOS: foram colhidas 50 amostras de fala de personagens idosos, 11 do sexo feminino e 39 do masculino, de 38 filmes hollywoodianos dos anos de 1993 a 2001. Através da análise perceptivo-auditiva das amostras de fala, 20 fonoaudiólogos treinados classificaram cada personagem em idoso e não idoso, além de avaliarem as vozes quanto aos seguintes parâmetros citados pela literatura como mais alterados: rouquidão, crepitação, soprosidade, tensão, aspereza, astenia, nasalidade, tremor, modulação, pitch e estabilidade da frequência fundamental. RESULTADOS: após a análise perceptivo-auditiva, foi observado que a grande maioria dos atores (82% utilizou voz de idoso para representar seus papéis. O marcador mais evidente nas vozes foi alteração na qualidade vocal (92%, demonstrada por crepitação (80%, soprosidade (54%, tensão (38%, rouquidão (30% e astenia (28%. O segundo marcador mais utilizado pelos atores nas suas representações foi a modulação vocal ampla e variada (44%. Também foram observadas alterações no controle da voz (36% e instabilidade da frequência fundamental (38%. CONCLUSÃO: a partir dos resultados obtidos pode-se concluir que os filmes de Hollywood caracterizam o idoso através de desvios evidentes na qualidade e modulação da voz, utilizando tipos de vozes alteradas e modulação vocal ampla e instável.PURPOSE: to describe the vocal quality of Hollywood movies characters playing elderly people roles. METHODS: a total of 50 aged character voice samples were used, 11 female and 39 male, from 38 Hollywood movies from the period between 1993 and 2001. Twenty speech therapists performed a perceptual auditory analysis. The listener's task required classifying each character either as elderly or as adult by their speech features, and also assessing their voices following the parameters that are most frequently addressed in the

  20. Asymmetry of cerebral blood flow in patients with senile dementia of Alzheimer type by SPECT using I-123 IMP

    Energy Technology Data Exchange (ETDEWEB)

    Arai, Hisayuki; Hanyu, Haruo; Kobayashi, Yasutaka; Hatano, Nobuyoshi; Katsunuma, Hideyo; Suzuki, Takanari; Amino, Saburo [Tokyo Medical Coll. (Japan)

    1990-12-01

    Regional cerebral blood flow (rCBF) was determined by single photon emission CT (SPECT) with N-isopropyl-p-({sup 123}I)iodoamphetamine in 22 patients with clinically diagnosed senile dementia of Alzheimer type (SDAT) and in 18 age matched controls. We calculated asymmetry indices (AIs) of rCBF for matched right-left regions of interest. rCBF of parietal lobe in SDAT patients was significantly most laterally asymmetrycal, but the least in occipital lobe. Lateral asymmetry of rCBF in SDAT patients correlated with asymmetry of language and visuospatial functions; decreased rCBF in the left parietal lobe was associated with language dysfunction, and that in the right parietal lobe, with viduospatial dysfunction. Furthermore cerebellar AIs correlated negatively with those of the cerebral hemisphere and lower frontal region in SDAT patients. The results demonstrate that rCBF measurement by {sup 123}I-IMP SPECT is useful to detect lateral asymmetry in reduction of rCBF in SDAT. (author).

  1. A quantitative comparison of plaque types in Alzheimer's disease and senile dementia of the Lewy body type.

    Science.gov (United States)

    McKenzie, J E; Edwards, R J; Gentleman, S M; Ince, P G; Perry, R H; Royston, M C; Roberts, G W

    1996-01-01

    In a previous study we reported no difference in the overall beta-amyloid protein (beta AP) load between Alzheimer's disease (AD) and senile dementia of the Lewy body type (SDLT). However, it is possible that differences in the morphology of beta AP plaque types exist, analogous to the differences in cytoskeletal pathology found in these two disorders. We have carried out a quantitative image analysis of plaque subtypes in the temporal lobe of AD (n = 8), SDLT (n = 9) and control (n = 11) cases. Measurements of beta AP load and plaque density were consistently higher in AD and SDLT than in controls. When AD and SDLT cases were compared no differences were seen in either the density or relative proportions of classic and diffuse plaques. Based on these results we suggest that the variation in the clinical course of these diseases reflects differences in the cytoskeletal pathology, whereas the final stages of profound dementia common to both disorders is associated with the deposition of beta AP.

  2. Asymmetry of cerebral blood flow in patients with senile dementia of Alzheimer type by SPECT using I-123 IMP

    International Nuclear Information System (INIS)

    Arai, Hisayuki; Hanyu, Haruo; Kobayashi, Yasutaka; Hatano, Nobuyoshi; Katsunuma, Hideyo; Suzuki, Takanari; Amino, Saburo

    1990-01-01

    Regional cerebral blood flow (rCBF) was determined by single photon emission CT (SPECT) with N-isopropyl-p-[ 123 I]iodoamphetamine in 22 patients with clinically diagnosed senile dementia of Alzheimer type (SDAT) and in 18 age matched controls. We calculated asymmetry indices (AIs) of rCBF for matched right-left regions of interest. rCBF of parietal lobe in SDAT patients was significantly most laterally asymmetrycal, but the least in occipital lobe. Lateral asymmetry of rCBF in SDAT patients correlated with asymmetry of language and visuospatial functions; decreased rCBF in the left parietal lobe was associated with language dysfunction, and that in the right parietal lobe, with viduospatial dysfunction. Furthermore cerebellar AIs correlated negatively with those of the cerebral hemisphere and lower frontal region in SDAT patients. The results demonstrate that rCBF measurement by 123 I-IMP SPECT is useful to detect lateral asymmetry in reduction of rCBF in SDAT. (author)

  3. Cerebral blood flow and oxygen metabolism in senile dementia of Alzheimer's type and vascular dementia with deep white matter changes

    International Nuclear Information System (INIS)

    Tohgi, H.; Yonezawa, H.; Takahashi, S.; Sato, N.; Kato, E.; Kudo, M.; Hatano, K.; Sasaki, T.

    1998-01-01

    Regional cerebral blood flow (rCBF), cerebral metabolic rate of oxygen (rCMRO 2 ), oxygen extraction fraction (rOEF), and cerebral blood volume (rCBV) were investigated using positron emission tomography (PET) in 16 patients with senile dementia of Alzheimer's type (SDAT), and compared with those of 6 nondemented and 3 demented patients with deep white matter high signal (DWMH) on T2-weighted MRI and 6 controls. rCBF, rCMRO 2 and rCBV were determined using C 15 O 2 , 15 O 2 and C 15 O, respectively. rCBF and CMRO 2 were significantly decreased in the frontal, parietal and temporal cortex (P 2 was significantly reduced in only the frontal and temporal cortex of demented patients (P < 0.05). rOEF was significantly increased in the parietal cortex of patients with SDAT and in the white matter of patients with SDAT or DWMH (P < 0.05), and the increase in the frontal white matter significantly paralleled the progression of dementia in patients with SDAT (P < 0.05). rCBV was significantly decreased in the parietal and temporal cortex of patients with SDAT (P < 0.05), but not in any areas of those with DWMH. (orig.)

  4. Efficacy and safety of short-term application of pranoprofen eye drops for senile patients with dry eyes

    Directory of Open Access Journals (Sweden)

    Yu-Chan Li

    2018-06-01

    Full Text Available AIM:To investigate the efficacy and safety of short-term application of pranoprofen eye drops in the treatment of dry eyes in senile patients. METHODS: Totally 100 elderly patients with dry eyes treated in our hospital from June 2016 to May 2017 were randomly divided into 2 groups. All cases were bilateral onset, and the right eyes were marked as the observation eyes. The 50 eyes in the observation group were treated with 1g/L pranoprofen eye drops combined with 1g/L sodium hyaluronate eye drops, while 50 in the control group were treated with 1g/L sodium hyaluronate eye drops. The results of Schirmer Ⅰ, ocular surface disease index(OSDI, break-up time(BUT, ocular surface staining(OSS, human leukocyte antigen-DR(HLA-DRand CD11b in conjunctival epithelial cells before and at 2wk after treatment, and adverse reactions in 2 groups were observed. RESULTS: Before treatment, results of Schirmer I, OSDI, BUT, OSS, HLA-DR and CD11b in the two groups were similar, there were no statistically significant differences(P>0.05. After treatment, OSDI, OSS, HLA-DR, CD11b significantly decreased, BUT significantly increased in both groups, the differences were statistically significant(PPPCONCLUSION: Short term application of pranoprofen eye drops can effectively enhance the efficacy in treating elderly patients with dry eyes, release clinical symptoms, and the therapeutic mechanism may be related to the inhibitory effect on HLA-DR.

  5. Effect Of Using Black Cumin (Nigella Sativa) As Natural Antioxidant On Hyperlipidaemia And Antioxidant Activities In Senile Rats

    International Nuclear Information System (INIS)

    HAMZA, R.G.; MAHMOUD, K.A.

    2009-01-01

    The black cumin (Nigella sativa) is one of the important herbal plants that used widely in most of human diseases and food preservation. Chemical composition of irradiated black cumin (10 kGy); moisture, ash, crude protein, crude lipid, total carbohydrate and crude fiber, were evaluated. The GC for analysis of fatty acids showed that the number of identified fatty acids was 9; the important one was linoleic (natural antioxidant). GC/MS used for analysis of essential oil showed that the number of identified compounds was 16; the important ones were thymoquinone, eugenol and linalool (natural antioxidants). Also, this study was performed to examine the efficacy of the black cumin to ameliorate the induced hyperlipidemia in senile rats. Twenty eight male rats were equally and randomly categorized into four groups. High fat diet (20g fat / 100g diet) was daily administered to rats for 6 weeks. Other animals where fed daily on either raw or irradiated black cumin diet (1% w/w) for 6 weeks. The results revealed that high fat diet fed to rats significantly induced an increase in serum phospholipids, TG, TC, LDL-C, atherogenic index and lipid peroxides (MDA). Significant decrease was observed in HDL-C, blood antioxidant enzymes activity (superoxide dismutase and catalase) and concentration of reduced glutathione (GSH). The results obtained revealed that feeding rats on diet containing either raw or irradiated black cumin (1% w/w) induced significant improvement in the above mentioned parameters. There was non- significant difference between non-irradiated and irradiated black cumin. Moreover, supplementation of black cumin in diet of rats can offer protection against free radicals generated through oxidative stress as a consequence of hyperlipidemic food.

  6. Effect Of Using Black Cumin (Nigella Sativa) As Natural Antioxidant On Hyperlipidaemia And Antioxidant Activities In Senile Rats

    Energy Technology Data Exchange (ETDEWEB)

    HAMZA, R G; MAHMOUD, K A [Food Irradiation Research Dept., National Centre for Radiation Research and Technology, Atomic Energy Authority, Cairo (Egypt)

    2009-07-01

    The black cumin (Nigella sativa) is one of the important herbal plants that used widely in most of human diseases and food preservation. Chemical composition of irradiated black cumin (10 kGy); moisture, ash, crude protein, crude lipid, total carbohydrate and crude fiber, were evaluated. The GC for analysis of fatty acids showed that the number of identified fatty acids was 9; the important one was linoleic (natural antioxidant). GC/MS used for analysis of essential oil showed that the number of identified compounds was 16; the important ones were thymoquinone, eugenol and linalool (natural antioxidants). Also, this study was performed to examine the efficacy of the black cumin to ameliorate the induced hyperlipidemia in senile rats. Twenty eight male rats were equally and randomly categorized into four groups. High fat diet (20g fat / 100g diet) was daily administered to rats for 6 weeks. Other animals where fed daily on either raw or irradiated black cumin diet (1% w/w) for 6 weeks. The results revealed that high fat diet fed to rats significantly induced an increase in serum phospholipids, TG, TC, LDL-C, atherogenic index and lipid peroxides (MDA). Significant decrease was observed in HDL-C, blood antioxidant enzymes activity (superoxide dismutase and catalase) and concentration of reduced glutathione (GSH). The results obtained revealed that feeding rats on diet containing either raw or irradiated black cumin (1% w/w) induced significant improvement in the above mentioned parameters. There was non- significant difference between non-irradiated and irradiated black cumin. Moreover, supplementation of black cumin in diet of rats can offer protection against free radicals generated through oxidative stress as a consequence of hyperlipidemic food.

  7. Clinical efficacy comparison of flabby skin excision combined orbicularis oculi muscle shortening surgery in patients with senile entropion

    Directory of Open Access Journals (Sweden)

    Qing-Liang Xu

    2015-07-01

    Full Text Available AIM: To observe the clinical effect of slack skin excision combined with orbicularis oculi muscle shortening and orbicularis muscle shortening in the treatment of elderly patients with lower eyelid entropion, and provide the reference for the clinical treatment.METHODS: Eighty-two(126 eyesclinical diagnosis's elderly patients with lower eyelid entropion were collected from our department, then randomly divided into excised relaxing skin and orbicularis oculi muscle shortening treatment group and the orbicularis muscle shortening treatment group.The general data of the two groups, long term curative effect and short-term curative effect were compared. RESULTS: The age, sex, proportion of patients with the first time operation, course of disease were no statistical significance between the observation group and the control group(P>0.05. The short-term effective rate of the observation group was 95.2%, while the short-term effective rate of the control group was 77.8%, the short-term efficiency differences between the two groups was statistical significance(χ2=4.100, P=0.043. The long-term cure rate of the observation group was 82.5%(34 cases, 52 eyes, recurrence rate was 17.5%(7 cases, 11 eyes, while the cure rate of the control group was 60.3%(25 cases, 38 eyes, recurrence rate was 39.7%(16 cases, 25 eyes, the difference of long term cure rate was statistical significance between the two groups(PCONCLUSION: The clinical curative effect of slack skin excision combined with orbicularis oculi muscle shortening in the treatment of senile inferior entropion is better than orbicularis muscle shortening operation, recommending application in the clinical.

  8. NELL-1 Injection Maintains Long-Bone Quantity and Quality in an Ovariectomy-Induced Osteoporotic Senile Rat Model

    Science.gov (United States)

    Kwak, Jinny; Zara, Janette N.; Chiang, Michael; Ngo, Richard; Shen, Jia; James, Aaron W.; Le, Khoi M.; Moon, Crystal; Zhang, Xinli; Gou, Zhongru; Ting, Kang

    2013-01-01

    Over 10 million Americans have osteoporosis, and is the predominant cause of fractures in the elderly. Treatment of fractures in the setting of osteoporosis is complicated by a suboptimal bone regenerative response due to a decline in the number of osteoblasts, their function, and survival. Consequently, an osteogenic therapeutic to prevent and treat fractures in patients with osteoporosis is needed. Nel-like molecule-1 (NELL-1), a novel osteoinductive growth factor, has been shown to promote bone regeneration. In this study, we aim to demonstrate the capacity of recombinant NELL-1 to prevent ovariectomy (OVX)-induced osteoporosis in a senile rat model. Ten-month-old female Sprague-Dawley rats underwent either sham surgery or OVX. Subsequently, 50 μL of 600 μg/mL NELL-1 lyophilized onto a 0–50-μm tricalcium phosphate (TCP) carrier was injected into the femoral bone marrow cavity while phosphate-buffered saline (PBS) control was injected into the contralateral femur. Our microcomputed tomography results showed that OVX+PBS/TCP control femurs showed a continuous decrease in the bone volume (BV) and bone mineral density (BMD) from 2 to 8 weeks post-OVX. In contrast, OVX+NELL-1/TCP femurs showed resistance to OVX-induced bone resorption showing BV and BMD levels similar to that of SHAM femurs at 8 weeks post-OVX. Histology showed increased endosteal-woven bone, as well as decreased adipocytes in the bone marrow of NELL-1-treated femurs compared to control. NELL-1-treated femurs also showed increased immunostaining for bone differentiation markers osteopontin and osteocalcin. These findings were validated in vitro, in which addition of NELL-1 in OVX bone marrow stem cells resulted in increased osteogenic differentiation. Thus, NELL-1 effectively enhances in situ osteogenesis in the bone marrow, making it potentially useful in the prevention and treatment of osteoporotic fractures. PMID:23083222

  9. Survival in the pre-senile dementia frontotemporal lobar degeneration with TDP-43 proteinopathy: effects of genetic, demographic and neuropathological variables

    Directory of Open Access Journals (Sweden)

    Richard A. Armstrong

    2016-06-01

    Full Text Available Factors associated with survival were studied in 84 neuropathologically documented cases of the pre-senile dementia frontotemporal dementia lobar degeneration (FTLD with transactive response (TAR DNA-binding protein of 43 kDa (TDP-43 proteinopathy (FTLD-TDP. Kaplan-Meier survival analysis estimated mean survival as 7.9 years (range: 1-19 years, SD = 4.64. Familial and sporadic cases exhibited similar survival, including progranulin (GRN gene mutation cases. No significant differences in survival were associated with sex, disease onset, Braak disease stage, or disease subtype, but higher survival was associated with lower post-mortem brain weight. Survival was significantly reduced in cases with associated motor neuron disease (FTLD-MND but increased with Alzheimer’s disease (AD or hippocampal sclerosis (HS co-morbidity. Cox regression analysis suggested that reduced survival was associated with increased densities of neuronal cytoplasmic inclusions (NCI while increased survival was associated with greater densities of enlarged neurons (EN in the frontal and temporal lobes. The data suggest that: (1 survival in FTLD-TDP is more prolonged than typical in pre-senile dementia but shorter than some clinical subtypes such as the semantic variant of primary progressive aphasia (svPPA, (2 MND co-morbidity predicts poor survival, and (3 NCI may develop early and EN later in the disease. The data have implications for both neuropathological characterization and subtyping of FTLD-TDP.

  10. Effectiveness and safety of celecoxib combined with diacerein in the treatment of senile degenerative knee osteoarthritis: study protocol and preliminary results of a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Guo-dong Wang

    2017-01-01

    Full Text Available Background and objectives: The non-steroidal anti-inflammatory drug celecoxib, used for the treatment of senile degenerative knee osteoarthritis, has a rapid onset of action and few side effects. However, it cannot prevent the occurrence and development of knee osteoarthritis. Celecoxib withdrawal is likely to induce a rebound increase in inflammation that may aggravate symptoms. Diacerein is a drug used to improve articular cartilage metabolism. It can delay the progression of senile degenerative knee osteoarthritis, but has a slow onset of action. Whether combined treatment with celecoxib and diacerein provides complimentary actions to achieve a better therapeutic effect on senile degenerative knee osteoarthritis remains unclear. >Design: A prospective, single-center, randomized controlled trial. Methods: Three hundred patients with senile degenerative knee osteoarthritis who receive treatment at the Department of Orthopedics, Second Affiliated Hospital of Nanjing Medical University, China will be randomly assigned to the celecoxib (200 mg, once a day, orally, diacerein (50 mg, twice a day, orally, and celecoxib + diacerein (celecoxib 200 mg, once a day, orally and diacerein 50 mg, twice a day, orally groups, with 100 patients in each group. Patients in each group will be treated for 12 successive weeks, and a 36-week follow-up will be performed. At 24 weeks after treatment, the VAS score for pain during the 20-meter walk test and osteoarthritis index were significantly decreased in the diacerein and celecoxib + diacerein groups compared to pre-treatment (P Outcome measures and preliminary results: The primary outcome measure of this study is the Visual Analogue Scale (VAS score for pain during the 20-meter walk test before and 1, 4, 12, 24, and 36 weeks after treatment. The secondary outcome measures of this study include osteoarthritis index and X-ray image findings of the knee before and 1, 4, 12, 24, and 36 weeks after treatment, as well

  11. [Pathogenetic associations of periodontal diseases with somatic therapeutic pathology, comorbid conditions in patients of advanced and senile age: state-of-the-art review. Part 1. Associations of periodontal diseases with somatic therapeutic pathology in patients of advanced and senile age].

    Science.gov (United States)

    Ar'eva, G T; Solov'ev, M M; Ar'ev, A L; Ryzhak, G A

    2014-01-01

    The state-of-the-art review of literature on existing views on the association of periodontal diseases with somatic therapeutic pathology (first part of the review) and comorbid conditions (second part of the review) is submitted. The conclusion about need of carrying out the further multicenter researches which purpose is development of new integrated indicators, in a complex and comprehensively characterizing not only the periodontal status, but also set of available somatic therapeutic pathology, especially at pa- tients of advanced and senile age is drawn.

  12. 99mTc-HMPAO-SPECT in the diagnosis of senile dementia of Alzheimer's type - a study under clinical routine conditions

    International Nuclear Information System (INIS)

    Stoppe, G.; Staedt, J.; Schuetze, R.; Kunert, H.J.; Ruether, E.; Koegler, A.; Sandrock, D.; Emrich, D.

    1995-01-01

    This study was designed to evaluate whether investigations of cerebral blood flow can be a helpful diagnostic tool in the differential diagnosis between (senile) dementia of Alzheimer's type [(S)DAT] and geriatric depression with cognitive impairment. Under clinical routine conditions we performed Single Photon Emission Computed Tomography (SPECT) using 99m Tc-Hexamethylpropyleneamine Oxime (HMPAO) in 23 patients with (S)DAT (14 f, 9 m; mean age 68.9 y), 17 patients with geriatric depression (9 f, 8 m; mean age 66.4 y) and 12 age-matched controls (9 f, 3 m; mean age 69.2 y). Semiquantitative analysis (corticocerebellar ratios) of eight different regions of interest (ROI) revealed a significantly ( p 99m Tc-HMPAO SPECT is a valuable additional tool in the differential diagnosis of depression and dementia in the elderly. (author)

  13. Xenon contrast CT-CBF scanning of the brain differentiates normal age-related changes from multi-infarct dementia and senile dementia of Alzheimer type

    International Nuclear Information System (INIS)

    Tachibana, H.; Meyer, J.S.; Okayasu, H.; Shaw, T.G.; Kandula, P.; Rogers, R.L.

    1984-01-01

    Local cerebral blood flow (LCBF) and partition coefficients (L lambda) were measured during inhalation of stable xenon gas with serial CT scanning among normal volunteers (N . 15), individuals with multi-infarct dementia (MID, N . 10), and persons with senile dementia of Alzheimer type (SDAT, N . 8). Mean gray matter flow values were reduced in both MID and SDAT. Age-related declines in LCBF values in normals were marked in frontal cortex and basal ganglia. LCBF values were decreased beyond normals in frontal and temporal cortices and thalamus in MID and SDAT, in basal ganglia only in MID. Unlike SDAT and age-matched normals, L lambda values were reduced in fronto-temporal cortex and thalamus in MID. Multifocal nature of lesions in MID was apparent. Coefficients of variation for LCBFs were greater in MID compared with SDAT and/or age-matched normals

  14. Quantification of beta A4 protein deposition in the medial temporal lobe: a comparison of Alzheimer's disease and senile dementia of the Lewy body type.

    Science.gov (United States)

    Gentleman, S M; Williams, B; Royston, M C; Jagoe, R; Clinton, J; Perry, R H; Ince, P G; Allsop, D; Polak, J M; Roberts, G W

    1992-08-03

    The distribution of beta-amyloid protein (beta A4) was examined in the medial temporal lobes from cases of Alzheimer's disease (AD) (n = 13), senile dementia of Lewy body type (SDLT) (n = 12) and age matched controls (n = 9). Using a previously described image analysis technique the extent of beta A4 pathology was determined in ten distinct anatomical sites within the medial temporal lobe. AD and SDLT cases contained very similar amounts of beta A4 in the areas sampled and both contained significantly more beta A4 than the age matched controls, particularly in the dentate and parahippocampal gyri. The similarity of the beta A4 load in the two conditions is in contrast to reported differences in the number of neurofibrillary tangles which can be observed. It is suggested that AD and SDLT represent a spectrum of pathology which centres around the aberrant processing of the beta A4 precursor protein.

  15. Prevalence of presenile dementia in a tertiary outpatient clinic Prevalência de demência pré-senil num ambulatório terciário

    Directory of Open Access Journals (Sweden)

    Satomi Fujihara

    2004-09-01

    Full Text Available There are very few reports about prevalence of presenile dementia in Brazil. We reviewed files of patients evaluated with early onset of cognitive impairment in our institution. Among 141 patients (61% males there was no difference between gender by age at onset or at first evaluation. We have observed an increasing number of patients after 50 years. The most frequent causes were: vascular dementia (36.9%, Alzheimer's disease (20.3% and traumatic brain injury (9.2%. There was difference among dementia type by age of onset and first evaluation, educational level and length of dementia. These results may be compared with those from other neurologic services in order to replicate or confirm these results.Em nosso meio há raros estudos que verifiquem quais as causas mais prevalentes de demência pré-senil. Avaliamos retrospectivamente os prontuários de pacientes com início precoce de alterações cognitivas, ambulatório de Neurologia da Cognição do Hospital Santa Marcelina. Entre os 141 sujeitos (61% de homens não houve diferença quanto às idades de início e à primeira consulta e escolaridade entre os sexos. Observamos aumento no número de demência após os 50 anos. A causa mais freqüente foi vascular (36,9%, seguida por doença de Alzheimer (20,3% e secundária a trauma cranio encefálico (9,2%. Houve diferença entre os tipos de demência quanto à idade na primeira consulta e idade de início, escolaridade e duração do quadro. Ao contrário de outros estudos o diagnóstico mais freqüente foi demência vascular. Novos estudos em nosso meio deverão ser realizados para avaliar este achado nas demências de início precoce.

  16. Regional cerebral blood flow and brain atrophy in senile dementia of Alzheimer type (SDAT). Comparing with multi-infarct dementia (MID), and aged control

    Energy Technology Data Exchange (ETDEWEB)

    Okada, K; Kobayashi, S; Yamaguchi, S; Kitani, M; Tsunematsu, T

    1987-05-01

    To investigate the relationship between the reduction of cerebal blood flow and brain atrophy in SDAT, these were measured in 13 cases of senile dementia of Alzheimer type, and compared to 15 cases of multi-infarct Dementia, 39 cases of lacunar infarction without dementia (non-demented CVD group) and 69 cases of aged normal control. Brain atrophy was evaluated by two-dimensional method on CT film by digitizer and regional cerebral blood flow (rCBF) was measured by /sup 133/Xe inhalation method. The degree of brain atrophy in SDAT was almost similar of that of MID. But it was more severe than that of non-demented group. MID showed the lowest rCBF among these groups. SDAT showed significantly lower rCBF than that of aged control, but rCBF in SDAT was equal to that of lacunar stroke without dementia. Focal reduction of cerebral blood flow in bilateral fronto-parietal and left occipital regions were observed in SDAT. Verbal intelligence score (Hasegawa's score) correlated with rCBF and brain atrophy index in MID, and a tendency of correlation between rCBF and brain atrophy in MID was also observed. However, there was no correlation among those indices in SDAT. These findings suggest that the loss of brain substance dose not correspond to the reduction of rCBF in SDAT and simultaneous measurement of rCBF and brain atrophy was useful to differ SDAT from MID.

  17. Quantitative cerebral blood flow assessment in senile dementia of Alzheimer type and multi-infarct dementia using sup 123 I-IMP SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Arai, Hisayuki; Hanyu, Haruo; Kobayashi, Yasutaka; Uno, Masanobu; Hatano, Nobuyoshi; Shin, Kouichi; Katsunuma, Hideyo; Suzuki, Takanari; Murayama, Hiroyasu [Tokyo Medical Coll. (Japan)

    1990-06-01

    In order to compare senile dementia of Alzheimer type (SDAT) with multi-infarct dementia (MID) from the standpoint of cerebral blood flow, a study was carried out by using single photon emission CT (SPECT) with N-isopropyl-p-({sup 123}I) iodoamphetamine on 14 healthy aged subjects, 12 patients with SDAT, 8 patients with MID and 7 patients with multiple infarction (MI). The diagnosis of SDAT, MID and MI was based on a clinical history, X-ray CT findings and Hachinski's ischemic score. Venous blood sampling method of Matsuda et al. was used as quantitative cerebral blood flow measurements. The mean cerebral blood flow (mCBF) values in controls was 52.1{plus minus}5.5 ml/100 g/min, while the corresponding values in SDAT, MI and MID were 36.9{plus minus}5.0, 41.0{plus minus}6.2, and 37.7{plus minus}4.3 ml/100 g/min. The regional cerebral blood flow (rCBF) was decreased mainly at bilateral frontal lobes in MID and at temporal and parietal lobes in SDAT. Verbal intelligence score (Hasegawa's dementia score) correlated with rCBF at frontal lobes in MID. These findings suggest that quantitative rCBF measurement by {sup 123}I-IMP SPECT is useful to differentiate MID from SDAT. (author).

  18. Regional cerebral blood flow and its correlation with clinical assessment in senile dementia of Alzheimer type and multi-infarct dementia

    International Nuclear Information System (INIS)

    Shinohara, Masao; Kawakatsu, Shinobu; Morinobu, Shigeru; Oiji, Arata; Sagawa, Katsuo; Yazaki, Mitsuyasu; Totsuka, Shirou; Komatani, Akio; Yamaguchi, Koichi

    1989-01-01

    Twenty-one patients with senile dementia of Alzheimer type (SDAT), 11 patients with multi-infarct dementia (MID), and 6 healthy volunteers were examined by SPECT using Xe-inhalation method. These patients also underwent an intelligence test according to the Gottfries-Brane-Steen (GBS) scale. Patients with mild SDAT did not have a significantly decreased regional cerebral blood flow (rCBF). In moderate or severe cases, however, a significantly decreased rCBF was bilaterally observed in all regions, except for the basal ganglia. This was marked in the temporoparietal region. A group of moderate or severe MID patients had a significantly decreased rCBF especially in the basal ganglia. It was also observed in the temporoparietal region, but not in the frontal region. Among the SDAT patients, there was a good correlation between rCBF and GBS scale in all the regions, except for the basal ganglia. In the case of MID patients, correlations were observed both between rCBF in the left side of the brain and clinical findings according to the method of Hasegawa and between rCBF in the right side of the frontal region and the motor function on the GBS scale. These findings may have implications for the different pathophysiology between SDAT and MID. (N.K.)

  19. An evaluation of the predictive validity and inter-rater reliability of clinical diagnostic criteria for senile dementia of Lewy body type.

    Science.gov (United States)

    McKeith, I G; Fairbairn, A F; Bothwell, R A; Moore, P B; Ferrier, I N; Thompson, P; Perry, R H

    1994-05-01

    Several recent autopsy studies suggest that senile dementia of Lewy body type (SDLT) may be the second most common neuropathologic cause of dementia in the elderly, accounting for 7 to 30% of all cases. Operational criteria for the antemortem clinical diagnosis of SDLT have already been proposed by our group. The performance of these is now examined by randomizing the case notes from a new series of SDLT, Alzheimer, and multi-infarct dementia patients for psychiatric assessment by four raters of varying clinical experience and blind to pathologic diagnosis. Using the SDLT criteria, the two most experienced raters agreed in 94% of cases (kappa = 0.87), with the least experienced rater agreeing in 78% (kappa = 0.50). Diagnostic specificity for SDLT was uniformly high (90.0 to 97.0%), with a mean sensitivity of detection of 74%, and was greater by the experienced (90.0%) than the least experienced (55%) clinician. The antemortem identification of SDLT patients can therefore be achieved with a high degree of diagnostic specificity using such operationalized criteria, although there remains a minority of patients who present with either "typical" Alzheimer-type symptoms or with paranoid or delusional symptoms in the absence of substantial cognitive impairment. Sensitivity to neuroleptics may be a useful diagnostic pointer in these patients.

  20. Do differences in visuospatial ability between senile dementias of the Alzheimer and Lewy body types reflect differences solely in mnemonic function?

    Science.gov (United States)

    Sahgal, A; McKeith, I G; Galloway, P H; Tasker, N; Steckler, T

    1995-02-01

    Visuospatial memory was investigated in two groups of patients suffering from senile dementias of the Alzheimer (SDAT) or Lewy body (SDLT) types; a, third, age-matched, healthy control group was also included. The two patient groups were mildly demented and could not be distinguished from each other by traditional tests of cognitive function. A different pattern of performance emerged in the two groups on a computerised test of spatial working memory, which is a self-ordered pointing task requiring the subject to search for hidden tokens. An analysis of the pattern of errors revealed that the SDLT group made more of both possible types of error ("Within Search" and "Between Search") than the SDAT group. Neither patient groups' performance differed from each other when assessed on a computerised Corsi spatial span task. A measure of planning ability was obtained by examining search strategies. Although an index previously developed to measure the subject's use of a particular strategy in the spatial working memory task failed to detect any differences between the three groups, a novel index was calculated which focuses on performance within a search, and this revealed deficits in both demented groups. Since the two patient groups differed from each other in the spatial working memory, but not the Corsi spatial span, task, it is suggested that the differences between the two demented groups are not due to a specific mnemonic impairment, but reflect dysfunctions in non-mnemonic processes mediated by fronto-subcortical circuits, which are more severely damaged in SDLT.

  1. Somatostatin-immunoreactive senile plaque-like structures in the frontal cortex and nucleus accumbens of aged tree shrews and Japanese macaques.

    Science.gov (United States)

    Yamashita, Akiko; Fuchs, Eberhard; Taira, Masato; Yamamoto, Takamitsu; Hayashi, Motoharu

    2012-06-01

    Previously, we demonstrated decreased expression of somatostatin mRNA in aged macaque brain, particularly in the prefrontal cortex. To investigate whether or not this age-dependent decrease in mRNA is related to morphological changes, we analyzed somatostatin cells in the cerebra of aged Japanese macaques and compared them with those in rats and tree shrews, the latter of which are closely related to primates. Brains of aged macaques, tree shrews, and rats were investigated by immunohistochemistry with special emphasis on somatostatin. We observed degenerating somatostatin-immunoreactive cells in the cortices of aged macaques and tree shrews. Somatostatin-immunoreactive senile plaque-like structures were found in areas 6 and 8 and in the nucleus accumbens of macaques, as well as in the nucleus accumbens and the cortex of aged tree shrews, where amyloid accumulations were observed. Somatostatin degenerations may be related to amyloid accumulations and may play roles in impairments of cognitive functions during aging. © 2012 John Wiley & Sons A/S.

  2. Quantification of microangiopathic lesions in brain parenchyma and age-adjusted mean scores for the diagnostic separation of normal from pathological values in senile dementia

    International Nuclear Information System (INIS)

    Hentschel, F.; Kreis, M.; Damian, M.; Krumm, B.; Froelich, F.

    2005-01-01

    Purpose: to quantify microangiopathic lesions in the cerebral white matter and to develop age-corrected cut-off values for separating normal from dementia-related pathological lesions. Materials and methods: in a memory clinic, 338 patients were investigated neuropsychiatrically by a psychological test battery and by MRI. Using a FLAIR sequence and a newly developed rating scale, white matter lesions (WMLs) were quantified with respect to localization, number and intensity, and these ratings were condensed into a score. The WML scores were correlated with the mini-mental state examination (MMSE) and clinical dementia rating (CDR) score in dementia patients. A non-linear smoothing procedure was used to calculate age-related mean values and confidence intervals, separate for cognitively intact subjects and dementia patients. Results: the WML scores correlated highly significantly with age in cognitively intact subjects and with psychometric scores in dementia patients. Age-adjusted WML scores of cognitively intact subjects were significantly different from those of dementia patients with respect to the whole brain as well as to the frontal lobe. Mean value and confidence intervals adjusted for age significantly separated dementia patients from cognitively intact subjects over an age range of 54 through 84 years. Conclusion: a rating scale for the quantification of WML was validated and age-adjusted mean values with their confidence intervals for a diagnostically relevant age range were developed. This allows an easy to handle, fast and reliable diagnosis of the vascular component in senile dementia. (orig.)

  3. 心理干预对老年期痴呆患者亲属心理健康状况的影响%The effects of psychological intervention on mental healthy status in relatives of patients with senile dementia

    Institute of Scientific and Technical Information of China (English)

    于相芬

    2011-01-01

    目的 探讨心理干预对老年期痴呆患者亲属心理健康状况的影响.方法 应用症状自评量表(SCL-90)和自制的老年期痴呆健康知识调查表对80名老年期痴呆患者亲属进行调查,并对其进行为期6周的心理干预.结果 老年期痴呆患者亲属心理干预前SCL-90总分及各因子分均高于常模,差异有显著性(P<0.05或0.01);心理干预后患者亲属的SCL-90总分及各因子分较心理干预前有显著降低(P<0.01);心理干预后亲属对患者疾病相关知识的知晓度明显提高(P<0.01).结论 心理干预可有效改善老年期痴呆患者亲属的心理健康状况.%Objective To explore the effects of psychological intervention on mental healthy status in relatives of patients with senile dementia. Methods Psychological intervention was conducted for 6 weeks in 80 relatives of patients with senile dementia. Symptom checklist 90 (SCL- 90) and self- designed health knowledge questionnaire were used to assess the effects of intervention. Results Total score and factor scores of SCL - 90 in relatives of patients with senile dementia were significantly higher than those of norm ( P < 0.05 or 0. 01 ) before the intervention, and decreased significantly after psychological intervention (P <0.01 ). Health knowledge in relatives of patients with senile dementia was improved significantly after intervention ( P < 0.01 ). Conclusion Psychological intervention can improve the mental healthy status of relatives of patients with senile dementia.

  4. Senile dementia of Lewy body type and Alzheimer type are biochemically distinct in terms of paired helical filaments and hyperphosphorylated tau protein.

    Science.gov (United States)

    Harrington, C R; Perry, R H; Perry, E K; Hurt, J; McKeith, I G; Roth, M; Wischik, C M

    1994-01-01

    We have used biochemical assays to examine cingulate and occipital cortices from age-matched cases of Alzheimer's disease (AD; n = 12), senile dementia of the Lewy body type (SDLT; n = 13), Parkinson's disease (PD; 5 non-demented cases and 7 cognitively impaired cases) and controls (n = 11) for paired helical filaments (PHFs), phosphorylated and normal tau protein and beta/A4-protein. Whereas cingulate cortex is characterised by relatively high densities of cortical Lewy bodies in the SDLT cases and lower numbers in PD, these inclusion bodies were absent in the cingulate cortex from AD and control cases. Protease-resistant PHFs and hyperphosphorylated tau protein were found in AD and, at low levels, in a minority of SDLT cases. Qualitatively, both of these preparations were indistinguishable in SDLT from those found in AD but levels of both parameters in SDLT were less than 5% of those in AD. SDLT, PD and control groups did not differ from each other in terms of the quantity of protease-resistant PHFs or the level of hyperphosphorylated tau. Furthermore, PHF accumulation did not distinguish between PD cases with or without dementia. The levels of normal tau protein did not differ between the four groups. beta/A4 protein levels did not distinguish between PD and control groups, between AD and SDLT groups, or between SDLT and control groups for either cingulate or occipital cortices. Thus extensive accumulation of PHFs in either neurofibrillary tangles or dystrophic neurites is not a feature of either SDLT or PD. Our findings provide molecular support for the neuropathological and clinical separation of SDLT as a form of dementia that is distinct from AD.

  5. Influence of apolipoprotein E genotype on senile dementia of the Alzheimer and Lewy body types. Significance for etiological theories of Alzheimer's disease.

    Science.gov (United States)

    Harrington, C R; Louwagie, J; Rossau, R; Vanmechelen, E; Perry, R H; Perry, E K; Xuereb, J H; Roth, M; Wischik, C M

    1994-12-01

    Alzheimer's disease (AD) is associated with an increased frequency of the apolipoprotein E type epsilon 4 allele. To address both the disease and the allele specificity of this association, we have examined the apolipoprotein E allele distribution in 255 elderly persons including those with autopsy-confirmed AD, senile dementia of the Lewy body type (SDLT), vascular dementia, Parkinson's disease (PD) or Huntington's disease and in nondemented controls either with or without coronary complications. The epsilon 4 allele frequency was increased in SDLT (0.365) and AD (0.328) as compared with controls (0.147), PD (0.098), or Huntington's chorea (0.171). Coronary disease and vascular dementia were associated with marginally higher epsilon 4 allele frequencies than in controls. In PD, amyloid beta-protein accumulated to a greater extent in those cases possessing an epsilon 4 allele than in those without. Those PD cases with dementia were not distinguished from either controls or PD cases without dementia, whether tested biochemically or by apolipoprotein E genotype. It is the comparison of the results in AD and SDLT that yielded the most significant findings. There was a 1.8-fold excess of amyloid beta-protein in AD as compared with controls, and the levels in SDLT were intermediate between those in AD and controls. In contrast, AD was discriminated from both controls and SDLT by the substantial accumulation of paired helical filament tau and phosphorylated tau (both increased more than 20-fold as compared with controls). SDLT was nevertheless characterized by an increased epsilon 4 allele frequency in the absence of significant tau pathology (at least 10-fold less than that in AD). These findings indicate that tau processing is more specifically associated with AD than is amyloid beta-protein accumulation and that presence of the epsilon 4 allele is not an etiological factor that accounts for tau pathology.

  6. Studies of cerebral blood flow and metabolism in patients with senile dementia of the Alzheimer's type and diagnostic evaluation of the dementing illnesses by positron emission tomography

    International Nuclear Information System (INIS)

    Sakamoto, Shizuki

    1990-01-01

    This study was designed to determine cerebral dysfunction in senile dementia of the Alzheimer's type (SDAT). Regional cerebral blood flow (rCBF), oxygen extraction fraction and cerebral oxygen consumption (rCMRO 2 ) were studied in SDAT patients (n=16) and age-matched normal elderly people (n=5) by positron emission tomography (PET) using the O-15 labeled CO 2 and O 2 inhalation technique. The SDAT group had a significantly lower values in both rCBF and rCMRO 2 than the normal control. During the early stage of SDAT, rCMRO 2 was restricted to the temporal cortex; and it extended to the parietal and frontal cortices associated with a decreased rCBF as the disease progressed. Posterior temporal and posterior parietal association cortices were considered to be the most damageable part during the early stage. Bilateral differences in oxygen metabolism of the temporal and parietal cortices tended to be in accordance with clinical symptoms for disturbed speech and visuospatial function, suggesting the correlation between rCMRO 2 and rCBF in SDAT. Findings of PET in SDAT differed from those obtained in each patient with multi-infarct dementia or Pick disease, in that both rCBF and rCMRO 2 were inhomogeneously decreased over the whole cerebral cortex for multi-infarct dementia and in that homogeneously decreased rCBF and rCMRO 2 were restricted to the frontal and temporal cortices for Pick disease. PET may have a potential for differentiating various types of dementia. (N.K.)

  7. Computerized tomography findings in Fahr's syndrome Achados da tomografia computadorizada na síndrome de Fahr

    Directory of Open Access Journals (Sweden)

    Andréia V. Faria

    2004-09-01

    Full Text Available We analyzed computerized tomography (CT findings in six patients with Fahr's syndrome. They presented calcifications in basal ganglia, dentate nucleus, subcortical region and semioval center, due to alteration in calcium metabolism or due to senile relative hypoxemic state. The image pattern was not strictly related with etiology, although some differences in dystrophic senile calcifications (the only one present in semioval center and absent in subcortical region. CT is an easy exam, has maximum sensitivity and allows diagnosis, contributing to early treatment of many etiologies of Fahr's syndrome.Analisamos os achados de tomografia computadorizada (TC de seis pacientes com síndrome de Fahr. Eles apresentaram calcificações nos gânglios da base, núcleo denteado, região subcortical e centro semi-oval, devidas a distúrbios no metabolismo do cálcio ou a estado de hipóxia relativa, por senilidade. O padrão de imagem não apresenta relação clara com a etiologia, apesar de algumas diferenças no caso das calcificações distróficas senis (as únicas presentes nos centros semi-ovais e ausentes na região subcortical. TC é um exame de fácil realização, máxima sensibilidade e permite o diagnóstico, contribuindo para o tratamento precoce de muitas das etiologias da síndrome de Fahr.

  8. Načrtovan porod na domu

    OpenAIRE

    Todorović, Tamara; Takač, Iztok

    2017-01-01

    Izhodišča: Porod na domu je sicer star toliko kot človeštvo, pa vendar v veliki večini srednje in visoko razvitih držav prevladuje mnenje, da so zaradi nepredvidljivosti zapletov porodnišnice najbolj varno okolje za rojevanje. Kljub temu obstaja peščica držav, v katerih je porod na domu integriran v sistem zdravstvenega varstva (npr. Nizozemska, Velika Britanija, Kanada). Pri porodih na domu ločimo nenačrtovane in načrtovane porode na domu, slednje pa lahko nadalje razdelimo še na porode s sp...

  9. Comparison of laser microprobe mass spectrometry (LMMS) and micro particle induced x-ray emission (micro-PIXE) for the analysis of senile plaques in Alzheimer`s disease. A preliminary study

    Energy Technology Data Exchange (ETDEWEB)

    Lovell, M A; Robertson, J D; Ehmann, W D [Kentucky Univ., Lexington, KY (United States). Dept. of Chemistry; Markesbery, W R [Kentucky Univ., Lexington, KY (United States); Teesdale, W J; Campbell, J L [Guelph Univ., ON (Canada). Dept. of Physics

    1995-08-01

    Results of micro-PIXE analysis of senile plaques (SP) in Alzheimer`s disease (AD) brain have been utilized to independently confirm levels of iron (Fe) as measured by LMMS in adjacent brain sections. LMMS concentrations were calculated based on the preparation and analysis of an iron calibration curve prepared in our laboratory. The LMMS standards consist of iron cis-dicylclohexano-18-crown-6 ether coordination complexes dissolved in Spurr`s low viscosity embedding medium. To our knowledge, this is the first report of the use of micro-PIXE, with its spatial resolution and detection limits comparable to that of LMMS, in the validation of LMMS results. The agreement observed between results obtained for Fe by micro-PIXE and LMMS indicates that the use of our LMMS standards, at least in the case of Fe, yields accurate results. (author). 6 refs., 1 fig., 1 tab.

  10. Parametri za procena na kvalitetot na polietilenska i na polipropilenska ambalaza i na gumeni zatvoraci nameneti za farmacevtski preparati

    Directory of Open Access Journals (Sweden)

    Liljana Ugrinova

    2002-03-01

    Full Text Available Napraven e pregled na parametrite za procena na kvalitetot na polietilenska i na polipropilenska ambalaza i na gumeni zatvoraci nameneti za farmacevtski preparati. Za procena na kvalitetot na ispituvaniot materijal bea izvrseni fizicki, hemiski i bioloski ispituvanja spored postapkite dadeni vo Ph. Eur., DIN i spored DIN ISO standardite. Baranjata za kvalitet na ovoj vid ambalaza propisani spored Ph. Eur., DIN i DIN ISO standardite se razlikuvaat vo odnos na predvidenite parametri za fizicki, za hemiski i za bioloski ispituvanja. Isto taka, propisani se i razlicni granici na dozvoleno otstapuvanje na oddelni parametri.

  11. Regional cerebral blood flow and its correlation with clinical assessment in senile dementia of Alzheimer type and multi-infarct dementia. A study with SPECT using sup 133 Xe inhalation method

    Energy Technology Data Exchange (ETDEWEB)

    Shinohara, Masao; Kawakatsu, Shinobu; Morinobu, Shigeru; Oiji, Arata; Sagawa, Katsuo; Yazaki, Mitsuyasu; Totsuka, Shirou; Komatani, Akio; Yamaguchi, Koichi [Yamagata Univ. (Japan). Faculty of Medicine

    1989-09-01

    Twenty-one patients with senile dementia of Alzheimer type (SDAT), 11 patients with multi-infarct dementia (MID), and 6 healthy volunteers were examined by SPECT using Xe-inhalation method. These patients also underwent an intelligence test according to the Gottfries-Brane-Steen (GBS) scale. Patients with mild SDAT did not have a significantly decreased regional cerebral blood flow (rCBF). In moderate or severe cases, however, a significantly decreased rCBF was bilaterally observed in all regions, except for the basal ganglia. This was marked in the temporoparietal region. A group of moderate or severe MID patients had a significantly decreased rCBF especially in the basal ganglia. It was also observed in the temporoparietal region, but not in the frontal region. Among the SDAT patients, there was a good correlation between rCBF and GBS scale in all the regions, except for the basal ganglia. In the case of MID patients, correlations were observed both between rCBF in the left side of the brain and clinical findings according to the method of Hasegawa and between rCBF in the right side of the frontal region and the motor function on the GBS scale. These findings may have implications for the different pathophysiology between SDAT and MID. (N.K.).

  12. At NA2

    CERN Multimedia

    1977-01-01

    One of the NA2 calorimeter sections is moved in. The NA2 calorimeter was divided in two halves, to the left and the right of the beam, each half consisting of sheets of passive high Z material interleaved with blades of plastic scintillators. The photo shows on the right, the upstream 'electron' module with eleven lead plates for a total radiation length of 20.

  13. Effect of Aqueous Extract of Salvia Miltiorrhiza Bge.F.alba on the Improvement of Learning and Memory Disturbance in Senile Mice%白花丹参水提物对衰老小鼠学习记忆障碍的影响

    Institute of Scientific and Technical Information of China (English)

    李聚仓; 郑辉; 王德才; 王浩

    2011-01-01

    目的:研究白花丹参水提物对衰老小鼠学习、记忆障碍作用的影响.方法:小鼠灌胃给予白花丹参水提物,连续6周,利用Y型迷宫、跳台法和自主活动仪,观察白花丹参水提物对D-半乳糖所致学习记忆障碍的影响.结果:结果表明白花丹参水提物能明显改善D-半乳糖所致的学习记忆障碍的能力(P<0.05或P<0.01).结论:白花丹参水提物对于衰老小鼠的学习、记忆障碍有明显的改善作用.%Objective:To study the effects of aqueous extract of Salvia miltiorrhiza Bge.F.alba on the improvement of learning and memory disturbance in senile mice.Methods :The mice were ig aqueous extract of Salvia miltiorrhiza Bge.F.alba for six weeks continuously.The learning and memory ability of senile mice which was caused by D - galactose were determined with Y - maze test and step - down test, and autonomic activities test.Result: The aqueous extract of Salvia miltiorrhiza Bge.F.alba improved the learning and memory function of dysmnesia mice caused by D - galactose (P <0.05 或 P <0.01 ).Conclusion:The aqueous extract of Salvia miltiorrhiza Bge.F.alba could improve learning and memory disturbance in senile mice.

  14. Polarization dependence of Na* + Na* associative ionization revisited

    NARCIS (Netherlands)

    Meijer, H.A.J.; Meulen, H.P. v.d.; Morgenstern, R.; Hertel, I.V.; Meyer, E.; Witte, R.

    1986-01-01

    The dependence of the associative ionization process Na 3 2P3/2 + Na 3 2P3/2 → Na2+ + e- on the polarization of the laser light used for Na excitation was independently investigated in Utrecht and Berlin. The purpose of this paper is to clarify discrepancies between two other earlier experimental

  15. NAKUPOVANJE NA SPLETU

    OpenAIRE

    Visenjak, Monika

    2013-01-01

    Nakupovanje na spletu je prihodnost poslovanja. Za podjetja pomeni manjše stroške, lažje prilagajanje tržnim pogojem. Hitreje lahko razvijajo odnose in analizirajo uporabnike, saj jim je dan dostop o nakupnih podatkih uporabnika. Za potrošnike je nakupovanje na spletu možnost hitrega, preprostega in učinkovitega nakupovanja od doma ali pisarne. Pomembno je, da se seznanijo z vsemi informacijami in pogoji spletnih trgovin, saj se lahko le tako izognejo nezadovoljstvu ob nakupu v spletni trgovi...

  16. Riso na epilepsia

    Directory of Open Access Journals (Sweden)

    Edymar Jardim

    1967-06-01

    Full Text Available São estudados três casos de síndrome convulsiva temporal, com manifestações concomitantes de riso na sua fase inicial. As características principais foram a imotivação e á incoercibilidade do riso. Esses sintomas desapareceram com o uso de anticonvulsivantes.

  17. Correction of senile entropion using holmium laser

    Science.gov (United States)

    Kecik, Mariusz; Kecik, Dariusz; Kasprzak, Jan; Brodecka, Malgorzata

    2003-10-01

    Ninety-eight patients were included in clinical trials. They were divided into 3 groups, depending on the severity of lower lid inversion. Eighteen patients were included in the group with mild lid inversion; 59 patients had moderate lid inversion and in 21 patients the inversion was severe. Additionally, the patients were subdivided into two groups, according to their age - up to and above the age of 69 years. In both age groups, patients with moderate entropion predominated. All patients underwent photocoagulation of the lower lid. Post-operative wound healing took about 14 days. The effect was described as good when the position of the lid returned to normal with the lashes at an angle of about 45° to the free edge of the eyelid. When the position of the eyelid was normal with the lashes at an angle of about 60° or more to the edge of the lid and not rubbing against the globe, the effect was considered satisfactory. When the inversion of the lid was not corrected, the effect was unsatisfactory. Good effects were seen in 61% of patients, 21% of the patients demonstrated satisfactory effects and in 18% the outcome was unsatisfactory. The best results were observed in patients with mild entropion, aged 69 years and younger.

  18. Senile dementia of the Alzheimer type

    Energy Technology Data Exchange (ETDEWEB)

    Hutton, J.T.; Kenny, A.D.

    1985-01-01

    This book contains papers on Alzheimer's Disease. They are divided into several topics. The topic headings are: Clinical Evaluation, Management, and Treatment; Related Clinical Disorders; Epidemiology and Genetics; Basic Science; and National Perspectives and Future Directions.

  19. Atletismo na escola : realidade?

    OpenAIRE

    Sampaio, Alessandro Oliveira de

    2012-01-01

    O correr, saltar, lançar e arremessar são elementos básicos do atletismo, sendo fundamentais para o ser humano, devido ao favorecimento do desenvolvimento físico e motor. Sendo um dos conteúdos principais do desporto e da educação física escolar, foi realizado um estudo relacionado à prática do atletismo na escola, na qual o objetivo desta pesquisa foi verificar se entre os professores de educação física da rede pública de ensino fundamental de 5ª a 8ª séries, da cidade satélite de Samambaia ...

  20. Preparing for NA4

    CERN Multimedia

    CERN PhotoLab

    1977-01-01

    Here, in one of the EF workshop, Albert Duchêne works on a pretty piece of mechanics. A few others await to be attended on the left. There are indications that the pipes were meant to house the carbon target (subdivided in eight sections) to be installed inside the toroid magnet of the NA4 experiment. The external strips were designed to possibly correct the magnetic field (???).

  1. The CERES / NA45 experiment

    CERN Multimedia

    Laurent Guiraud

    2000-01-01

    Ceres is one of the second generation heavy ion experiments at CERN's SPS. It is dedicated to the study of electron-positron pairs in relativistic nuclear collisions. NA45 is one of the seven experiments (NA44, NA45, NA49, NA50, NA52, WA97/NA57 and WA98) involved in CERN's Heavy Ion programme which provided evidence for the existence of a new state of matter, the quark-gluon plasma. In this state, quarks, instead of being bound up into more complex particles such as protons and neutrons, are liberated and roam freely. Theory predicts that this state must have existed at about 10 microseconds after the Big Bang, before the formation of matter as we know it today.

  2. Envolvimento pulmonar na polimiosite

    Directory of Open Access Journals (Sweden)

    Direndra Hasmucrai

    2010-07-01

    Full Text Available Resumo: Introdução: A polimiosite (PM e a dermatomiosite são classificadas como miopatias inflamatórias idiopáticas. O envolvimento pulmonar por PM é pouco frequente, estando descrito na literatura em cerca de 10% de casos.Os autores apresentam um caso de uma mulher de 75 anos, com queixas de febre, perda ponderal, artralgias, mialgias e diminuição simétrica e proximal da força muscular com impotência funcional dos membros superiores e inferiores, com início um mês antes do internamento. Apresentava infiltrados pulmonares na telerradiografia de tórax. Após estudo exaustivo estabeleceu-se o diagnóstico de envolvimento pulmonar na forma de pneumonia organizativa por PM. Efectuou-se corticoterapia e terapêutica com micofenolato com melhoria clínica, analítica e radiológica. Conclusão: Neste caso, foi a alteração na telerradiografia de tórax numa doente sem sintomatologia respiratória que levou ao estudo exaustivo até ao diagnóstico de PM, realçando mais uma vez a importância da telerradiografia no rastreio de patologias de outros foros. Abstract: Introduction: Polymyositis and dermatomyositis are classified as idiopathic inflammatory myopathies. Interstitial lung disease is rare and is described in the literature in about 10% of cases.The authors describes a case of 75 year old woman presenting with one month evolution of fever, weight loss, arthralgia, myalgia and symmetric and proximal muscle weakness of upper and lower limbs. Nonspecific interstitial changes was found in chest X-ray. After exhaustive study, the diagnosis of pulmonary envolvement in the form of organizing pneumonia by polymyositis, was established. Glucocorticoids and mycophenolate were prescribed with good clinical, analytical and radiological outcome. Conclusion: In this case, it was the changes in the chest X-ray in a patient without respiratory symptomatology, that conducted to exhaustive study to polymyositis diagnosis, enhancing once again the

  3. Comprometimento pulmonar na leptospirose

    Directory of Open Access Journals (Sweden)

    Jorge Eduardo Manhães de Carvalho

    1992-03-01

    Full Text Available Em 23 pacientes com leptospirose apresentando comprometimento pulmonar, internados no Hospital Universitário Antônio Pedro da XJFF, Niterói, hemoptise e hemoptóicos foram observados em 21,7% e 30,4%, respectivajnente. Gasometria arterial revelou hipoxemia e hipocapnia na maioria dos casos. Radiografia de tórax em 15 pacientes mostrou comprometimento alveolar em 60%, comprometimento intersticial-reticular em 6%, padrão misto (alveolar e intersticial em20%e ausência de alterações radiológicas em 14%. A necrópsiade 13 pacientes mostrou edema, congestão e hemorragia nos pulmões em 100% dos casos. A hemorragia foi focal em 46% e difusa em 54% dos casos. Houve formação de membrana hialina em 30% e trombos de fibrina em 46% dos pulmões estudados, o que estabelece o diagnóstico da coagulação intravascular disseminada e a ocorrência da síndrome de angústia respiratória na leptospirose.

  4. Measurement of exchangeable sodium: 22Na or 24Na

    International Nuclear Information System (INIS)

    Smith, T.; Edmonds, C.J.

    1987-01-01

    A case is made for the use of 22 Na in low activities in preference to 24 Na for routine diagnostic estimation of exchangeable sodium, and is based chiefly on considerations of availability, cost and radiation dosimetry. A method in which only 37 kBq (1 μCi) 22 Na is administered orally is shown to be sufficiently accurate and to possess distinct advantages in terms of cost and convenience with a committed radiation dose no greater than that for a measurement using 24 Na. (author)

  5. Prevalência de transtornos oculares na população de idosos residentes na cidade de Veranópolis, RS, Brasil Prevalence of ocular diseases in a population of elderly residents of the city of Veranópolis, Brazil

    Directory of Open Access Journals (Sweden)

    Flávio Antônio Romani

    2005-10-01

    Full Text Available OBJETIVO: Avaliar os transtornos oculares e a sua prevalência em pessoas com 80 anos de idade, ou mais, na cidade de Veranópolis, Rio Grande do Sul, Brasil. MÉTODOS: 187 idosos foram submetidos a exame oftalmológico por meio de inspeção externa, motilidade extrínseca, medidas de acuidade visual para longe e perto, tonometria de aplanação, biomicroscopia, cicloplegia, fundoscopia direta e esquiascopia estática. RESULTADOS: As doenças mais prevalentes foram: presbiopia em 173 (92,5% pacientes, catarata em 160 (85,6%, ectrópio senil em 130 (69,5%, hipermetropia em 130 (69,5% e a degeneração macular relacionada à idade (DMRI em 59 (31,5%. Na população estudada, 85 (45,4% pacientes apresentaram baixa visual acentuada cujas causas principais eram a catarata em 46 (54,1% e erros de refração em 16 (18,9% dos idosos. A principal causa de queixas dos idosos foi relacionada com a presença de ectrópio senil. CONCLUSÃO: Doenças comuns como a catarata e os erros de refração continuam a ser um desafio para os oftalmologistas, pois são importantes causas de dificuldade visual nos idosos, com conseqüente perda de qualidade em suas vidas.ABSTRACT PURPOSE: To evaluate the prevalence of diseases of the eye in a population aged 80 years and above in the city of Veranopolis, Rio Grande do Sul, Brazil. METHODS: 187 elderly people were submitted to ophthalmologic tests including external inspection, ocular motility examination, visual acuity determination for near and far distance, applanation tonometry, biomicroscopy, cyclopegia, direct fundus examination and static skiascopy. RESULTS: The most prevalent disease was presbyopia in 173 (92,5% patients, cataract in 160 (85,6%, age-related ectropion in 130 (69,5%, hypermetropia in 130 (69,5% and age-related macular degeneration (ARMD in 59 (31,5% patients. 85 (45,4% patients presented marked low vision whose main causes were cataract in 46 (54,1% and refractive error in 16 (18,9% of the studied

  6. The NA27 trigger

    International Nuclear Information System (INIS)

    Bizzarri, R.; Di Capua, E.; Falciano, S.; Iori, M.; Marel, G.; Piredda, G.; Zanello, L.; Haupt, L.; Hellman, S.; Holmgren, S.O.; Johansson, K.E.

    1985-05-01

    We have designed and implemented a minimum bias trigger together with a fiducial volume trigger for the experiment NA27, performed at the CERN SPS. A total of more than 3 million bubble chamber pictures have been taken with a triggered cross section smaller than 75% of the total inelastic cross section. Events containing charm particles were triggered with an efficiency of 98 +2 sub(-3)%. With the fiducial volume trigger, the probability for a picture to contain an interaction in the visible hydrogen increased from 47.3% to 59.5%, reducing film cost and processing effort with about 20%. The improvement in data taking rate is shown to be negligible. (author)

  7. Na Cauda do Cometa

    Science.gov (United States)

    Voelzke, M. R.

    2009-01-01

    Quando viam um cometa, os antigos gregos imaginavam uma estrela com uma vasta cabeleira. Não à toa, a palavra deriva do termo koma, que significa cabelo. Constituídos por fragmentos de gelo e gases, os cometas possuem um núcleo sólido, que pode ter vários quilômetros de diâmetro, e uma cauda que sempre aponta na direção contrária ao Sol, devido aos ventos solares. Graças à aparência de pontos luminosos em movimento (ao contrário de outros astros, que parecem estáticos), esses corpos celestes foram interpretados por diferentes povos com muito misticismo, inspirando mitos tanto de boas-novas como de maus presságios. Conheça algumas dessas histórias:

  8. NA48 prototype calorimeter

    CERN Multimedia

    1990-01-01

    This is a calorimeter, a detector which measures the energy of particles. When in use, it is filled with liquid krypton at -152°C. Electrons and photons passing through interact with the krypton, creating a shower of charged particles which are collected on the copper ribbons. The ribbons are aligned to an accuracy of a tenth of a millimetre. The folding at each end allows them to be kept absolutely flat. Each shower of particles also creates a signal in scintillating material embedded in the support disks. These flashes of light are transmitted to electronics by the optical fibres along the side of the detector. They give the time at which the interaction occurred. The photo shows the calorimeter at NA48, a CERN experiment which is trying to understand the lack of anti-matter in the Universe today.

  9. A ENGENHARIA NA ESCOLA

    Directory of Open Access Journals (Sweden)

    Valéria Pelizzer Casara

    2015-04-01

    Full Text Available Este projeto teve por objetivo principal mostrar às jovens do ensino médio, como as áreas de exatas e de engenharia podem estar inseridas em situações rotineiras por elas vivenciadas e incentivá-las para ingressarem nessas áreas. O projeto foi executado na escola de ensino Médio Nelson Horostecki na cidade de Chapecó, Santa Catarina. Mostrou-se de forma simples que as áreas de exatas e de engenharia têm aplicações práticas nas nossas vidas. No desenvolvimento do projeto, realizaram-se oficinas na escola cujo tema principal abordado foi o processo de fabricação do chocolate, visto que o mesmo é um produto muito apreciado pelas adolescentes. Dentro dessa temática, foram trabalhadas as questões que envolvem conhecimentos das áreas de exatas e de engenharia, mais especificamente a Engenharia Ambiental. O projeto auxiliou na formação cidadã e também na escolha profissional das meninas. Muitas das alunas participantes nunca haviam tido contato direto com alunos graduandos de cursos na área das exatas. Mais ainda, este projeto oportunizou a aproximação da universidade com a comunidade externa. Palavras-chave: Extensão Universitária, Ciências Exatas e Engenharia, Chocolate, Oficinas.   Engineering in the school Abstract: The main objective of this project was to show high school female students how the exact sciences and engineering can be included in their routine situations encouraging them to entering in these areas. The project was carried out at the Nelson Horostecki High School in Chapecó, Santa Catarina State, Brazil. It was showed in a simple manner how exact sciences and engineering have practical applications in our lives. Workshops were conducted in the school during the execution of the project in which the main subject was the chocolate manufacturing process, since chocolate is a product greatly appreciated by the young female people. Within this matter, the activities were performed using the knowledge of

  10. Investigation on U - O - Na, Pu - O - Na and U,Pu - O - Na phase diagrams

    International Nuclear Information System (INIS)

    Pillon, S.

    1989-03-01

    The thermochemical interaction between the nuclear fuel (uranium and plutonium mixed oxides) and the sodium has been investigated and particularly the three phase diagrams: U - O - Na; Pu - O - Na; U,Pu - O - Na. High temperature neutron diffraction, microcalorimetry and powder X-ray diffraction were used for the characterization of the compounds synthetized. This study allowed to complete the knowledge about each of these diagrams and to measure some physical and thermal properties on the compounds. The limits on the modelization of the fuel-sodium interaction are discussed from the results of the UO 2 - Na reaction [fr

  11. Valores na escola

    Directory of Open Access Journals (Sweden)

    Menin Maria Suzana De Stefano

    2002-01-01

    Full Text Available Neste texto pretende-se discorrer sobre valores morais na escola e suas implicações para a formação de professores. Para tanto discutir-se-á, em primeiro lugar, e brevemente, o que são valores morais, ou éticos, e como a escola pode situar-se em relação a eles. Em seguida, serão relatadas algumas observações a respeito de valores de professores e práticas daí decorrentes. São comentados resultados de pesquisa que ilustram a transmissão de valores de forma doutrinal e a educação moral e cívica tal como realizada na ditadura militar, e, por outro lado, a posição relativista e/ou de laissez-faire que certas escolas podem adotar, metodologicamente, sobre a educação em valores. Finalmente, defender-se-á a idéia de que é necessária uma discussão sobre valores pelos diversos membros da escola e uma opção por uma metodologia para ensiná-los, seja os professores, em sua formação inicial e continuada, seja os alunos. A teoria de desenvolvimento moral de Jean Piaget será apresentada como uma referência possível para a educação em valores. Exemplos de situações escolares de conflito de valores entre direção, pais e alunos são discutidas para ilustrar como uma escola pode adotar um procedimento democrático de educação em valores, que se apresenta como um terceiro caminho possível de educação moral nas escolas, além das posições doutrinárias ou relativistas.

  12. A aposta na filosofia

    Directory of Open Access Journals (Sweden)

    Márcio Suzuki

    2011-12-01

    Full Text Available Para Hume, filosofar é uma atividade semelhante às demais ocupações humanas. A decisão que leva à atividade filosófica é menos resultado de uma argumentação teórica do que fruto de um cálculo prático, que é entendido como uma caça ou um jogo. O objetivo deste trabalho será o de mostrar que no jogo filosófico perde quem joga sério demais. A aposta na filosofia tem que passar pelo bom humor e pela diversão: uma resposta a Pascal?For Hume, philosophy is in itself neither more nor less important than other human activities. On the contrary, it can be explained from its resemblance with game and hunting. If one chooses to dedicate himself to philosophy, his decision is not the consequence of logical reasoning, but depends on practical evaluation, which has something to do with gambling. The following text tries to show that in philosophy, like in other games, the loser will be the one who plays too earnestly. The philosophical game requires good humour and some relaxation: Is this a good answer to Pascal's pari?

  13. 老年抑郁症患者血管紧张素转换酶基因多态性与认知功能关系研究%The relationships of the angiotensin converting enzyme gene polymorphism and cognitive function in senile depressive patients

    Institute of Scientific and Technical Information of China (English)

    王小泉; 王祖森; 袁勇贵

    2013-01-01

    目的 探讨老年抑郁症患者血管紧张素转换酶(ACE)基因第16内含子插入/缺失(Insertion/Deletion,I/D)多态性分布特征和认知功能及其之间的关系.方法 采用病例对照研究,病例组为97例符合美国精神障碍诊断统计手册第4版(Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition,DSM-Ⅳ)抑郁症诊断标准的住院患者,其中男性33例,女性64例,年龄60~78岁,平均年龄(68±5)岁;健康对照组103例,其中男性30例,女性73例,平均年龄(66±6)岁.所有的患者及44例健康对照者完成了汉密尔顿抑郁量表(HAMD)评估及神经心理学测试.用聚合酶链式反应(PCR)法进行ACE基因扩增和Ⅰ/D多态性分型.结果 患者组的神经认知测试成绩除连线测试B成绩外,其余的成绩都显著低于正常对照组(P<0.001);相关性分析显示患者组的数字广度测试(顺背)成绩与HAMD总分成负相关(r=-0.213,P=0.040).患者组和对照组间基因型及等位基因频率分布差异无统计学意义(x2=1.745,P=0.418;x2 =0.700,P=0.403);进一步按性别分层分布差异无统计学意义(P>0.05).患者组各基因型间在认知功能方面的差异无统计学意义(P>0.05).结论 老年抑郁症患者存在广泛的认知功能受损,抑郁严重程度与工作记忆成绩密切相关,ACE基因I/D多态性与老年抑郁症的发病及认知功能无显著关联性.%Objective To explore the relationships between angiotensin converting enzyme (ACE) gene polymorphism of insertion/deletion(I/D) and cognition function in senile depressive patients in Chinese Han population.Methods 97 patients with major depression were recruited according to the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition criteria,and 103 healthy persons were used as controls.The Hamilton Depression Scale (HAMD) and neuropsychological tests were used to assess depressive severity and cognitive function in all patients and 44 healthy

  14. VPLIV OSEBNOSTI NA STILE VODENJA

    OpenAIRE

    Vučak, Petra

    2009-01-01

    Nekatere naše vrline krasijo zlate lastnosti, druge pa kvarijo sivi odtenki. Če bi ljudje razumeli in spoznali svojo osebnost, ter osebnostne tipe drugih ljudi, bi se problemi pri komunikaciji občutno zmanjšali. Takrat bi namreč lažje uvideli, zakaj je nekdo reagiral na način, kot je ali zakaj je nekdo dejal to, kar je. Smisel tega je, da spoznamo svoje dobre lastnosti, ki jih lahko še bolj razvijemo, slabe pa poskušamo nadzorovati in tako zmanjšati njihov vpliv. Iskanje uspešnih in učink...

  15. SPOLNO NADLEGOVANJE NA DELOVNEM MESTU

    OpenAIRE

    Rubič, Gašper

    2016-01-01

    V diplomskem delu smo v uvodu predstavili problem spolnega nadlegovanja na delovnem mestu in predstavili podjetje TEKSTIL d.d. V nadaljevanju smo z anketo raziskali, ali problem spolnega nadlegovanja na delovnem mestu v obravnavanem podjetju obstaja in če, kako se nanj odziva okolje. V teoretičnem delu smo nadaljevali in predstavili definicijo spolnega nadlegovanja, ki je kakršna koli oblika nezaželenega verbalnega in neverbalnega ali fizičnega ravnanja spolne narave z učinkom ali nameno...

  16. Active transport of Na+ by reconstituted Na,K-ATPase

    International Nuclear Information System (INIS)

    Boldyrev, A.A.; Svinukhova, I.A.

    1987-01-01

    The ability of ATP, CTP, ITP, GTP, and UTP to support ouabain-sensitive accumulation of Na + by proteoliposomes with a reconstituted Na/K-pump was investigated. At a low [Na + ]/[K + ] ratio in the medium (20 mM/50 mM), a correlation is observed between the proton-accepting capacity of the nucleotide and its effectiveness as a substrate of active transport. To test the hypothesis of the importance of the presence of a negative charge in the 1-position of the purine (3-pyrimidine) base of the nucleotide for mutual transitions between the Na- and K-conformations of Na,K-ATPase they used two analogs of ATP: N 1 -hydroxy-ATP, possessing proton acceptor capacity, and N 1 -methoxy-ATP, in the molecule of which the negative charge is quenched by a methyl group. The first substrate supports active accumulation of Na + in proteoliposomes at the same rate as ATP, whereas the second substrate is relatively ineffective

  17. Beam monitoring at NA2

    CERN Multimedia

    1978-01-01

    Claus Goessling working on the beam Cerenkov counter of NA2. The muon beam enters from left the hall EHN2 and the last element of the beam transport. On background is the access door on the Jura side.

  18. Risbjerg: Historisk stemmeskred med NA

    DEFF Research Database (Denmark)

    Thomsen, Søren Risbjerg

    2007-01-01

    ANALYSE: NA flytter 12,3 pct. af stemmerne i majs meningsmålinger - historisk mange vælgere på en måned, skriver professor Risbjerg. Udgivelsesdato: 3. juni 2007......ANALYSE: NA flytter 12,3 pct. af stemmerne i majs meningsmålinger - historisk mange vælgere på en måned, skriver professor Risbjerg. Udgivelsesdato: 3. juni 2007...

  19. Na via do Behemoth

    Directory of Open Access Journals (Sweden)

    Gérard Rabinovitch

    2008-06-01

    Full Text Available O momento nazista permanece um enigma impensado de que a cultura contemporânea continua cativa. O autor levanta a hipótese de que a persistência desse enigma e seus estragos duráveis se devem à insistência dos pensamentos político, sociológico e filosófico em construírem o nazismo à luz da metáfora hobbesiana do Leviatã. Propõe retomar a questão do nazismo sob a perspectiva do Behemoth, antônimo do Leviatã. Para tanto, sugere a necessidade de retornar a Freud e à psicanálise, balizas de um possível novo pensamento do político que escrutine a destrutividade nazista. Propõe ainda sondar as homologias entre nazismo, corjas e máfias, com base na figura da " heroicização da violência" que lhes seria comum. E avança um modelo " econômico" : a quimera, suscetível de capturar o caráter heterotópico e heterocrônico de sua construção criminosa.The paths of Behemoth. The Nazi moment remains as the thoughtless enigma of which contemporary culture is still captive. The author raises the hypothesis where the persistency of this enigma and its durable damages are due to the insistence of the political, social and philosophical thoughts in building the Nazism at the view of the Hobbesian metaphor of Leviathan. It is here proposed to resume the Nazism matter under Behemoth's perspective, antonym to Leviathan. For such, it is suggested a necessity to look back at Freud and the psychoanalysis, structured by a possible new political thought which scrutinizes the destructivity of the Nazism. It is also here proposed to gaze at the homologies between Nazism, mafias and gangs, with a base in the figure of " violence as a heroically act" that are their common ground. The author also advances an economical model: the chimera susceptible to capture the heterotopic and heterochronic character of its criminal construction.

  20. Financiranje projekata na pomorskom dobru

    Directory of Open Access Journals (Sweden)

    Zoran Tasić

    2018-02-01

    Full Text Available Koncesije otvaraju vrlo osjetljiva politička, ekonomska i pravna pitanja u mnogim državama svijeta. Samo definiranje pojma koncesije često je komplicirana i ne sasvim jasna zadaća. OECD je prihvatila definiciju koncesije kao: ’’davanje prava privatnom trgovačkom društvu da može gospodarski upravljati određenom infrastrukturnim uslugama i za to zarađivati naknadu. Koncesionar dobija u posjed određene objekte (ali vlasništvo na tim objektima ostaje u rukama države te ih koristi u svrhu obavljanja određene djelatnosti ili usluge sukladno odredbama ugovora’’. Hrvatsko pravo definira koncesije načelno kao pravo stečeno temeljem ugovora o koncesiji, a sukladno uvjetima sadržanim u odluci o davanju koncesije (koju je donijelo odgovarajuće upravno tijelo, a u odnosu na pomorsko dobro, specifično, kao pravo državne vlasti da može dio pomorskog dobra, koje je inače dobro izvan pravnog prometa (res extra commercium, isključiti iz opće uporabe bilo dijelom ili u cijelosti, i dati ga fizičkoj ili pravnoj osobi na gospodarsko korištenje sukladno određenim prostornim planovima. Građevine i drugi objekti izgrađeni na pomorskom dobru čine njegov sastavni dio. Zakonom je jasno određeno da nikakva stvarna prava nisu dopuštena na pomorskom dobru, uključivo i na objektima izgrađenima na njemu. Projekti na pomorskom dobru često uključuju velike infrastrukturne projekte, razvoje luka i marina, koji iziskuju značajna financijska sredstva. Banke koje financiraju takve projekte zahtijevaju organiziran i transparentan zakonski okvir koncesija, slobodu ugovaranja, pravnu zaštitu svih strana uključenih u projekt (uključivo i mogućnost međunarodne arbitraže. (...

  1. Recikliranje plastenk na kreativen način

    OpenAIRE

    Pavlin, Suzana

    2017-01-01

    Plastenke, poleg ostalih plastičnih izdelkov, v zadnjih letih predstavljajo pravo katastrofo za okolje. Domnevamo, da se le redko kdo vpraša, kaj se zgodi z njo po tem, ko je iz nje zaužil še zadnjo kapljico vode. Plastenka je lahko kot večina ostalih komunalnih odpadkov ponovno uporabljena, reciklirana, sežgana ali odložena na deponijo. V primeru nespoštovanja Zakona o varstvu okolja pa pristane v naravi, pogosto v morju, kjer prav počasi razpada in negativno vpliva na celoten ekosistem. V d...

  2. All new for NA62

    CERN Multimedia

    Antonella Del Rosso

    2012-01-01

    This week sees the start of the first run of the new NA62 experiment. This will be a unique opportunity for the collaboration to test its new beam, new detectors and new data acquisition system before the physics run in 2014. Speaking to the Bulletin, the NA62 technical coordinator Ferdinand Hahn shares the many challenges that the various teams faced to be on time for beam. Ready, steady, start!   A Large Angle Veto detector (white) in place in the NA62 decay volume (blue). With components from almost all the detectors in place downstream of the decay point of the mother particles – the kaons – and of the KTAG detector that tags the kaons before they decay, NA62 is ready for its first technical run. This unique run will test all the equipment as well as the trigger and the data acquisition systems. “This year, we will have about five weeks of beam from the SPS before the long shutdown of all the CERN machines,” says Ferdinand Hahn, NA62 Technical Co-...

  3. Corpo e sexualidade na gravidez

    Directory of Open Access Journals (Sweden)

    Natalúcia Matos Araújo

    2012-06-01

    Full Text Available Estudo etnográfico que teve como objetivo compreender como as gestantes vivenciam os processos fisiológicos do seu corpo durante a gestação e a sua repercussão na sexualidade. A pesquisa envolveu sete mulheres residentes em bairro popular de São Paulo. Na coleta de dados, utilizou-se observação participante e entrevista com questões norteadoras. Os dados foram apresentados na forma de narrativa e posteriormente organizados nas categorias: Percebendo as transformações corporais; Convivendo com as mudanças no corpo; Sentimentos e sensações na vida sexual durante a gestação e imaginando o corpo e a sexualidade após a gestação. As mulheres referiram-se às transformações do corpo como desconfortos e expressaram a preocupação de que fossem definitivas. Expressaram o desejo de que, após o parto, o corpo volte a ser como era e que volte a sentir desejo sexual. O reconhecimento destes fatos constitui-se numa ferramenta primordial na adequação das práticas profissionais.

  4. gigapanorama of NA 62 cavern

    CERN Multimedia

    Brice, Maximilien

    2015-01-01

    The image shows the new rare Kaon decay experiment at CERN, called NA62. The NA62 experiment is 270 metres long and includes a 120-metre-long vacuum tank, shown here, housing several of the particle detectors. (Note: the experiment axis is a straight line, the curving of the tank is an optical effect of the photo.) Kaons are particles that decay into lighter elementary particles. The kaon decay processes are mostly well known, except for some very rare decay modes. For example, NA62 is investigating a rare decay predicted by the Standard Model in which a kaon decays into one pion and two neutrinos. This process occurs only once every 10 billion decays. The understanding of such ultra-rare decays are of great importance because they test the Standard Model in energy ranges not accessible by direct measurements. They are therefore complementary to the measurements at the LHC. ultra high definition on demand (photolab@cern.ch).

  5. Armas na escola: que fazer?

    Directory of Open Access Journals (Sweden)

    Raymundo de Lima

    2010-09-01

    Full Text Available

    Um aluno portava um revólver na sala de aula de uma escola de Maringá (O Diário, 30/07/2010. Ele pegou arma do pai, sem que este soubesse, para se proteger de garotos que o intimidavam. Trata-se de um caso isolado ou é hora de a escola tomar medidas preventivas? Semanas antes, tiros foram disparados dentro de uma faculdade da mesma cidade. O autor dos disparos está preso, e a faculdade tenta apagar as marcas com publicidade positiva na Tv. Em Campo Mourão, cidade a cerca de uma hora de Maringá, duas meninas foram mortas e enterradas na escola.

  6. OGLAŠEVANJE NA FACEBOOKU

    OpenAIRE

    Renko, Katica

    2013-01-01

    V magistrskem delu smo se seznanili z oglaševanjem na Facebooku. S pregledom gradiva, ki nam je ponujeno, smo preverili pogoje, načine, oblike … oglaševanja, ki pa smo jih s pregledom situacije v praksi preverili in dopolnili. Ob zaključku dela lahko rečemo, da je oglaševanje preko FB enostavnejše, cenejše, dostopnejše, omogoča nam ažurnost in samo komunikacijo z naslovniki, ki so potencialni kupci naših ponudb. Množični mediji nam omogočajo mnogotero obliko oglaševanja. Izbrana oblika ponuja...

  7. β decay of Na32

    Science.gov (United States)

    Mattoon, C. M.; Sarazin, F.; Hackman, G.; Cunningham, E. S.; Austin, R. A. E.; Ball, G. C.; Chakrawarthy, R. S.; Finlay, P.; Garrett, P. E.; Grinyer, G. F.; Hyland, B.; Koopmans, K. A.; Leslie, J. R.; Phillips, A. A.; Schumaker, M. A.; Scraggs, H. C.; Schwarzenberg, J.; Smith, M. B.; Svensson, C. E.; Waddington, J. C.; Walker, P. M.; Washbrook, B.; Zganjar, E.

    2007-01-01

    The β-decay of Na32 has been studied using β-γ coincidences. New transitions and levels are tentatively placed in the level scheme of Mg32 from an analysis of γ-γ and β-γ-γ coincidences. The observation of the indirect feeding of the 2321 keV state in Mg32 removes some restrictions previously placed on the spin assignment for this state. No evidence of a state at 2117 keV in Mg32 is found. Previously unobserved weak transitions up to 5.4 MeV were recorded but could not be placed in the decay scheme of Na32.

  8. Corpo-escrita na esquizofrenia

    OpenAIRE

    Bialer, Marina

    2014-01-01

    Este artigo aborda a importância do trabalho de escrita na esquizofrenia. Toma-se como ponto de partida a formulação lacaniana sobre o esquizofrênico como aquele que não tem as funções dos órgãos do seu corpo dadas pelos discursos estabelecidos. A hipótese de que o trabalho sobre a letra pode permitir o tratamento do gozo debordante na esquizofrenia é analisada pelo estudo da obra do escritor esquizofrênico Robert Walser, a qual evidencia a viabilidade da construção de um corpo pela escrita n...

  9. Meltability in system of K2TaF7-NaF-NaCl-KCl

    International Nuclear Information System (INIS)

    Kartsev, V.E.; Kovalev, F.V.; Korshunov, B.G.

    1975-01-01

    Thermographic and visual-polythermal techniques were used to study the meltability in K 2 TaF 7 -NaF-NaCl-KCl system. The tetrahedron-forming sections NaF-NaCl-K 2 TaF 7 xKCl and NaF-K 2 TaF 7 xKCl-2K 2 TaF 7 xNaCl divide the concentration tetrahedron into three particular tetrahedra: NaF-K 2 TaF 7 xKCl-2K 2 TaF 7 xNaCl-K 2 TaF 7 , NaF-NaCl-K 2 TaF 7 xKCl-2K 2 TaF 7 xaCl, and NaF-NaCl-KCl-K 2 TaF 7 xKCl. Non-variant equilibrium points in all of the particular four-component systems have been determined

  10. NA60 frees the quarks

    CERN Multimedia

    2003-01-01

    Fitted with new state-of-the-art silicon detectors, NA60 is prepared to study the phase transition from confined hadronic matter to a deconfined (free) quark-gluon plasma, a state of matter which probably existed an instant after the Big Bang.

  11. NA61/SHINE ion program

    CERN Document Server

    Mackowiak, Maja

    2010-01-01

    The Super Proton Synchrotron (SPS) at CERN covers one of the most interesting regions of the phase diagram (T - \\mu_{B}) of strongly interacting matter. The study of central Pb+Pb collisions by NA49 indicate that the threshold for deconfinement is reached already at the low SPS energies. Theoretical considerations predict a critical point of strongly interacting matter at energies accessible at the SPS. The NA61/SHINE experiment, a successor of the NA49 project, will study hadron production in p+p, p+A, h+A, and A+A reactions at various energies. The broad physics program includes the investigation of the properties of strongly interacting matter, as well as precision measurements of hadron spectra for the T2K neutrino experiment and for the Pierre Auger Observatory and KASCADE cosmic-ray projects. The main physics goals of the NA61/SHINE ion program are to study the properties of the onset of deconfinement at low SPS energies and to find signatures of the critical point of strongly interacting matter. To ach...

  12. NA62: Hidden Sector Physics

    CERN Document Server

    Cesarotti, Carissa Joyce

    2016-01-01

    Modern experimental physics is often probing for new physics by either finding deviations from predictions on extremely precise measurements, or by looking for a new signal that cannot be explained with existing models. The NA62 experiment at CERN does the former by measuring the ultra-rare decay $K^+ \\rightarrow \\pi^+ \

  13. The system NaVO3-Na2WO4-Na2W2O7

    International Nuclear Information System (INIS)

    Kazanbekov, V.R.; Gasanaliev, A.M.; Kazanbekov, R.G.

    1994-01-01

    Phase diagrams of sodium metavanadate-sodium ditungstate, sodium metavanadate-sodium tungstate systems and surface of primary crystallization of sodium metavabadate-sodium tungstate-sodium ditungstate system were studied. The system sodium metavanadate-sodium ditungstate is eutectic one. Compound NaVO 3 x2Na 2 WO 4 is formed in solid state in sodium metavanadate-sodium tungstate system. Liquidus surface of sodium metavanadate-sodium tungstate-sodium ditungstate is presented by three crystallization fields of initial components. Composition and melting point of ternary eutectics are determined

  14. Europlanet NA2 Science Networking

    Science.gov (United States)

    Harri, Ari-Matti; Szego, Karoly; Genzer, Maria; Schmidt, Walter; Krupp, Norbert; Lammer, Helmut; Kallio, Esa; Haukka, Harri

    2013-04-01

    Europlanet RI / NA2 Science Networking [1] focused on determining the major goals of current and future European planetary science, relating them to the Research Infrastructure that the Europlanet RI project [2] developed, and placing them in a more global context. NA2 also enhanced the ability of European planetary scientists to participate on the global scene with their own agenda-setting projects and ideas. The Networking Activity NA2 included five working groups, aimed at identifying key science issues and producing reference books on major science themes that will bridge the gap between the results of present and past missions and the scientific preparation of the future ones. Within the Europlanet RI project (2009-2012) the NA2 and NA2-WGs organized thematic workshops, an expert exchange program and training groups to improve the scientific impact of this Infrastructure. The principal tasks addressed by NA2 were: • Science activities in support to the optimal use of data from past and present space missions, involving the broad planetary science community beyond the "space club" • Science activities in support to the preparation of future planetary missions: Earth-based preparatory observations, laboratory studies, R&D on advanced instrumentation and exploration technologies for the future, theory and modeling etc. • Develop scientific activities, joint publications, dedicated meetings, tools and services, education activities, engaging the public and industries • Update science themes and addressing the two main scientific objectives • Prepare and support workshops of the International Space Science Institute (ISSI) in Bern and • Support Trans National Activities (TNAs), Joined Research Activities (JRAs) and the Integrated and Distributed Information Service (IDIS) of the Europlanet project These tasks were achieved by WG workshops organized by the NA2 working groups, by ISSI workshops and by an Expert Exchange Program. There were 17 official WG

  15. Pozitivni in negativni vplivi risank na otroke

    OpenAIRE

    Povše, Nika

    2017-01-01

    V tej diplomski nalogi smo raziskovali pozitivne in negativne vplive risank na otroke. Začeli smo z zgodovino televizije, tako svetovno zgodovino kot zgodovino televizije na Slovenskem. Na isti način smo pregledali tudi zgodovino risank. Raziskovali smo otrokov razvoj, predvsem tiste vidike, ki so izpostavljeni vplivom risank, kot so morala, jezik, domišljija in učenje. Sledilo je raziskovanje negativnih in pozitivnih vplivov, ki jih imajo risanke na otroke, kar je tudi naš glavni problem te ...

  16. Na+-stimulated ATPase of alkaliphilic halotolerant cyanobacterium Aphanothece halophytica translocates Na+ into proteoliposomes via Na+ uniport mechanism

    Directory of Open Access Journals (Sweden)

    Soontharapirakkul Kanteera

    2010-08-01

    Full Text Available Abstract Background When cells are exposed to high salinity conditions, they develop a mechanism to extrude excess Na+ from cells to maintain the cytoplasmic Na+ concentration. Until now, the ATPase involved in Na+ transport in cyanobacteria has not been characterized. Here, the characterization of ATPase and its role in Na+ transport of alkaliphilic halotolerant Aphanothece halophytica were investigated to understand the survival mechanism of A. halophytica under high salinity conditions. Results The purified enzyme catalyzed the hydrolysis of ATP in the presence of Na+ but not K+, Li+ and Ca2+. The apparent Km values for Na+ and ATP were 2.0 and 1.2 mM, respectively. The enzyme is likely the F1F0-ATPase based on the usual subunit pattern and the protection against N,N'-dicyclohexylcarbodiimide inhibition of ATPase activity by Na+ in a pH-dependent manner. Proteoliposomes reconstituted with the purified enzyme could take up Na+ upon the addition of ATP. The apparent Km values for this uptake were 3.3 and 0.5 mM for Na+ and ATP, respectively. The mechanism of Na+ transport mediated by Na+-stimulated ATPase in A. halophytica was revealed. Using acridine orange as a probe, alkalization of the lumen of proteoliposomes reconstituted with Na+-stimulated ATPase was observed upon the addition of ATP with Na+ but not with K+, Li+ and Ca2+. The Na+- and ATP-dependent alkalization of the proteoliposome lumen was stimulated by carbonyl cyanide m - chlorophenylhydrazone (CCCP but was inhibited by a permeant anion nitrate. The proteoliposomes showed both ATPase activity and ATP-dependent Na+ uptake activity. The uptake of Na+ was enhanced by CCCP and nitrate. On the other hand, both CCCP and nitrate were shown to dissipate the preformed electric potential generated by Na+-stimulated ATPase of the proteoliposomes. Conclusion The data demonstrate that Na+-stimulated ATPase from A. halophytica, a likely member of F-type ATPase, functions as an electrogenic Na

  17. Photodesorption of Na atoms from rough Na surfaces

    DEFF Research Database (Denmark)

    Balzer, Frank; Gerlach, R.; Manson, J.R.

    1997-01-01

    We investigate the desorption of Na atoms from large Na clusters deposited on dielectric surfaces. High-resolution translational energy distributions of the desorbing atoms are determined by three independent methods, two-photon laser-induced fluorescence, as well as single-photon and resonance......-enhanced two-photon ionization techniques. Upon variation of surface temperature and for different substrates (mica vs lithium fluoride) clear non-Maxwellian time-of-flight distributions are observed with a cos θ angular dependence and most probable kinetic energies below that expected of atoms desorbing from...... atoms are scattered by surface vibrations. Recent experiments providing time constants for the decay of the optical excitations in the clusters support this model. The excellent agreement between experiment and theory indicates the importance of both absorption of the laser photons via direct excitation...

  18. Vpliv konfucija na sodobno izobraževanje na Kitajskem

    Directory of Open Access Journals (Sweden)

    Katja Skitek

    2009-12-01

    Full Text Available Izobraževanje na Kitajskem je bilo vedno trdno povezano s Konfucijem in konfucianizmom, kar pa ni čudno, saj je bil Konfucij prvi, ki je poudarjal moč z nanja in izobraževanja. LR Kitajska je v zadnjih petdesetih letih počasi in postopoma začela uveljavljati določene spremembe v vzgojno-izobraževalni sistem. Kakšne so te spremembe in koliko nanje še vedno vpliva konfucianizem, bo osrednja tema pričujočega članka. Konfucianizem danes na Kitajskem ni preveč popularen, izobraženci pa so se razporedili v dve skupini: eni trdijo, da je njegov vpliv še vedno velik, drugi pa zatrjujejo, da nima več nobenega vpliva na sodobno življenje. Katera stran ima prav? Konfucij je v prvi vrsti poudarjal pomembnost moralnih vrednot vsakega človeka in prav moralne vrednote, za katere se je zavzemal, so še danes trdno zasidrane v kitajski kulturi. Ali je torej sploh mogoče popolnoma izriniti Konfucija iz sodobnega izobraževanja?

  19. Novel aspects of Na+,K+-ATPase

    OpenAIRE

    Aizman, Oleg

    2002-01-01

    Na,K-ATPase, an integral membrane protein expressed in each eukaryotic cell, serves as the major determinant of intracellular ion composition. In the current study we investigated novel aspects of Na,K-ATPase function and regulation. It is well established that Na,K-ATPase activity is regulated by reversible phosphorylation. New findings in this study are: 1) the level of intracellular Ca 2. concentration determines the functional effects of PKA and PKC-mediated Na,K-ATP...

  20. NA64 Status Report 2018

    CERN Document Server

    Gninenko, Sergei

    2018-01-01

    The experiment NA64 is aimed at a search for a sub-GeV vector mediator (called dark photon A′) of Dark Matter production at the CERN SPS. . The main goal in 2017 was to probe a region of the A′ parameter space of the thermal dark matter model. Ongoing activities on the detector and data analysis are reviewed. The status and results from the NA64 runs in 2016 and 2017 are reported. First results on the search for the X->e+e− decay of a 17 MeV X boson, which could explain the recently observed excess of e+e-pairs from the excited 8Be nucleus transitions, and A'-> e+e- decays are also presented. Ongoing analysis on the decays of axion-like particles and plans for further searches beyond LS2 are also discussed.

  1. Makosa Yanayofanywa na Wanafunzi Wanaojifunza Kiswahili kama ...

    African Journals Online (AJOL)

    Makala haya, yanashughulika na makosa ambayo hufanywa na wanafunzi wanaojifunza Kiswahili kama lugha ya pili katika shule za sekondari nchini Uganda. Mtafiti ameyaainisha makosa mbalimbali na kuyaeleza kiusahihi. Makala yanaeleza namna ambavyo makosa hayo hutokea. Yaani, kama ni makosa ...

  2. Pseudo-ternary phase diagram in the Na2O-Na2O2-NaOH system

    International Nuclear Information System (INIS)

    Saito, Jun-ichi; Tendo, Masayuki; Aoto, Kazumi

    1997-10-01

    Generally, the phase diagrams are always used to understand the present state of compounds at certain temperature. In order to understand the corrosion behavior of structural material for FBR by main sodium compounds (Na 2 O, Na 2 O 2 and NaOH), it is very important to comprehend the phase diagrams of their compounds. However, only Na 2 O-NaOH pseudo-binary phase diagram had been investigated previously in this system. There is no study of other pseudo-binary or ternary phase diagrams in the Na 2 O-Na 2 O 2 -NaOH system. In this study, in order to clarify the present states of their compounds at certain temperatures, the pseudo-binary and ternary phase diagrams in the Na 2 O-Na 2 O 2 -NaOH system were prepared. A series of thermal analyses with binary and ternary component system has been carried out using the differential scanning calorimetry (DSC). The liquidus temperature and ternary eutectic temperatures were confirmed by these measurements. The beneficial indications for constructing phase diagrams were obtained from these experiments. On the basis of these results, the interaction parameters between compounds which were utilized for the Thermo-Calc calculation were optimized. Thermo-Calc is one of thermodynamic calculation software. Consequently the accurate pseudo-binary and ternary phase diagrams were indicated using the optimized parameters. (author)

  3. Na+,K+-ATPase Na+ affinity in rat skeletal muscle fiber types

    DEFF Research Database (Denmark)

    Kristensen, Michael; Juel, Carsten

    2010-01-01

    Previous studies in expression systems have found different ion activation of the Na(+)/K(+)-ATPase isozymes, which suggest that different muscles have different ion affinities. The rate of ATP hydrolysis was used to quantify Na(+),K(+)-ATPase activity, and the Na(+) affinity of Na(+),K(+)-ATPase...

  4. Homocisteína Homocysteine

    Directory of Open Access Journals (Sweden)

    Lindalva Batista Neves

    2004-10-01

    Full Text Available A homocisteína, formada a partir da metionina hepática, é metabolizada nas vias de desmetilação e de transulfuração, sendo que seus valores plasmáticos e urinários refletem a síntese celular. Sua determinação, realizada em jejum e após sobrecarga de metionina, caracteriza as diferenças dessas vias metabólicas, principalmente quando de natureza genética. A hiper-homocisteinemia tem sido associada a maior risco de eventos aterotrombóticos, e a literatura sugere associação causal, independente de outros fatores de risco para doença arterial. Diminuição da homocisteína plasmática para valores normais é seguida de redução significante na incidência de doença aterotrombótica. A relação entre homocisteína e o fígado vem adquirindo importância nos dias atuais, uma vez que alterações das lipoproteínas e da depuração de metionina são comuns em pacientes com doença hepática crônica (hepatocelular e canalicular. O tratamento da hiper-homocisteinemia fundamenta-se na suplementação alimentar e medicamentosa de ácido fólico e vitaminas B6 e B12.Homocysteine, formed from hepatic methionine, is metabolized through the pathways of demethylation and transsulfuration. Its plasmatic and urinary values reflect the cell synthesis. Its determination after fasting and increased infusion of methionine shows the differences of these two metabolic pathways, mainly when it is related to genetic diseases. Hyperhomocysteinemia has been associated with a higher risk of vascular thrombotic events. Several authors suggest a causal relationship between these events independently of other risk factors for vascular diseases. Decrease in plasmatic homocysteine to normal levels is followed by a significant reduction on the incidence of vascular thrombotic events. The correlation between the liver and homocysteine is becoming more important because of the recent findings that alterations of lipoproteins and methionine clearance are

  5. Myocardial Na,K-ATPase: Clinical aspects

    OpenAIRE

    Kjeldsen, Keld

    2003-01-01

    The specific binding of digitalis glycosides to Na,K-ATPase is used as a tool for Na,K-ATPase quantification with high accuracy and precision. In myocardial biopsies from patients with heart failure, total Na,K-ATPase concentration is decreased by around 40%; a correlation exists between a decrease in heart function and a decrease in Na,K-ATPase concentration. During digitalization, around 30% of remaining pumps are occupied by digoxin. Myocardial Na,K-ATPase is also influenced by other drugs...

  6. Crowdsourcing: impactos na performance na venda de produtos

    OpenAIRE

    Alves, Milton Ruiz Rodrigues

    2015-01-01

    Vivemos num momento em que as expectativas de pensadores como Lévy (1998), se concretizaram. O consumidor mudou, passou a exigir um diálogo entre a empresa e a sociedade. Esse novo cenário cobrou da tecnologia formas de aperfeiçoar e agilizar este processo de comunicação, plataformas baseadas na internet que propiciem e incentivam a troca de informações. Nesta esfera surgiu o crowdsourcing, com a disponibilização do capital intelectual das massas, que acabou por mudar a form...

  7. Silicene for Na-ion battery applications

    KAUST Repository

    Zhu, Jiajie

    2016-08-19

    Na-ion batteries are promising candidates to replace Li-ion batteries in large scale applications because of the advantages in natural abundance and cost of Na. Silicene has potential as the anode in Li-ion batteries but so far has not received attention with respect to Na-ion batteries. In this context, freestanding silicene, a graphene-silicene-graphene heterostructure, and a graphene-silicene superlattice are investigated for possible application in Na-ion batteries, using first-principles calculations. The calculated Na capacities of 954mAh/g for freestanding silicene and 730mAh/g for the graphenesilicene superlattice (10% biaxial tensile strain) are highly competitive and potentials of >0.3 V against the Na/Na potential exceed the corresponding value of graphite. In addition, the diffusion barriers are predicted to be <0.3 eV.

  8. Hali ya taaluma ya ukalimani Tanzania: jana, leo na kesho ...

    African Journals Online (AJOL)

    Umuhimu wa ukalimani katika mawasiliano umeongezeka kutokana na utandawazi. Utandawazi umerahisisha kukutanika na kuwasiliana kwa watu wazungumzao lugha tofauti kupitia wakalimani. Kutokana na ongezeko hilo la umuhimu wa ukalimani, kumekuwa na jitihada mbalimbali katika nchi mbalimbali kuhakikisha ...

  9. New results from NA49

    CERN Document Server

    Afanasiev, S V; Bächler, J; Barna, D; Barnby, L S; Bartke, Jerzy; Barton, R A; Behler, M; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Blyth, C O; Boimska, B; Botje, M; Bracinik, J; Brady, F P; Bramm, R; Brun, R; Buncic, P; Carr, L; Cebra, D; Cerny, V; Cooper, G E; Cramer, J G; Csató, P; Dinkelaker, P; Eckardt, V; Eckhardt, F; Ferenc, D; Filip, P; Fischer, H G; Foder, Z; Foka, P Y; Freund, P; Friese, V; Gál, J; Ganz, R E; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Harris, J W; Hegyi, S; Höhne, C; Igo, G; Jacobs, P; Jones, P G; Kadija, K; Kolesnikov, V I; Kollegger, T; Kowalski, M; Kraus, I; Kreps, M; Lasiuk, B; Van Leeuwen, M; Lévai, Peter; Malakhov, A I; Margetis, S; Markert, C; Mayes, B W; Melkumov, G L; Mischke, A; Molnár, J; Nelson, J M; Odyniec, Grazyna Janina; Oldenburg, M; Pálla, G; Panagiotou, A D; Perl, K; Petridis, A; Pikna, M; Pinsky, L; Poskanzer, A M; Prindle, D J; Pühlhofer, F; Putschke, J; Reid, J G; Renfordt, A; Retyk, W; Ritter, H G; Röhrich, D; Roland, C; Roland, G; Rybicki, A; Sammer, T; Sann, H; Schäfer, E; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Snellings, R; Squier, G T A; Stock, Reinhard; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Toy, M; Trainor, T A; Trentalange, S; Ullrich, T S; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Voloshin, S A; Vranic, D; Wang, F; Weerasundara, D D; Wenig, S; Wetzler, A; Whitten, C; Xu, N; Yates, T A; Koo, I K; Zaranek, J; Zimányi, J

    2002-01-01

    Recent results of the NA49 experiment are presented. These cover first results on pion and kaon production, HBT, and charge fluctuations from Pb+Pb reactions at 40 AGeV and their comparison to 158 AGeV beam energy. Furthermore a study on baryon number transfer in p+p, centrality selected p+Pb and Pb+Pb collisions at 158 AGeV and new results on the system size dependence of kaon yields, including C+C and Si+Si data, are presented. Additionally, a first result on Lambda Lambda correlations is shown. (11 refs).

  10. Loucura imperial na Roma antiga

    Directory of Open Access Journals (Sweden)

    Aloys Winterling

    2012-06-01

    Full Text Available Este artigo aborda a questão da "loucura imperial" na Roma antiga, indagando-se sobre o que seria peculiar a ações de imperadores, como Calígula, Nero e Domiciano, que conduziu a conflitos com a aristocracia. Argumenta-se que apenas uma análise das estruturas e sistemas históricos do Alto Império possibilita explicar certos padrões de comportamento imperial, usualmente classificados como loucura pela historiografia dos séculos XIX e XX.

  11. The effect of Na vapor on the Na content of chondrules

    Science.gov (United States)

    Lewis, R. Dean; Lofgren, Gary E.; Franzen, Hugo F.; Windom, Kenneth E.

    1993-01-01

    Chondrules contain higher concentrations of volatiles (Na) than expected for melt droplets in the solar nebula. Recent studies have proposed that chondrules may have formed under non-canonical nebular conditions such as in particle/gas-rich clumps. Such chondrule formation areas may have contained significant Na vapor. To test the hypothesis of whether a Na-rich vapor would minimize Na volatilization reaction rates in a chondrule analog and maintain the Na value of the melt, experiments were designed where a Na-rich vapor could be maintained around the sample. A starting material with a melting point lower that typical chondrules was required to keep the logistics of working with Na volatilization from NaCl within the realm of feasibility. The Knippa basalt, a MgO-rich alkali olivine basalt with a melting temperature of 1325 +/- 5 C and a Na2O content of 3.05 wt%, was used as the chondrule analog. Experiments were conducted in a 1 atm, gas-mixing furnace with the fO2 controlled by a CO/CO2 gas mixture and fixed at the I-W buffer curve. To determine the extent of Na loss from the sample, initial experiments were conducted at high temperatures (1300 C - 1350 C) for duration of up to 72 h without a Na-rich vapor present. Almost all (up to 98%) Na was volatilized in runs of 72 h. Subsequent trials were conducted at 1330 C for 16 h in the presence of a Na-rich vapor, supplied by a NaCl-filled crucible placed in the bottom of the furnace. Succeeding Knudsen cell weight-loss mass-spectrometry analysis of NaCl determined the P(sub Na) for these experimental conditions to be in the 10(exp -6) atm range. This value is considered high for nebula conditions but is still plausible for non-canonical environments. In these trials the Na2O content of the glass was maintained or in some cases increased; Na2O values ranged from 2.62% wt to 4.37% wt. The Na content of chondrules may be controlled by the Na vapor pressure in the chondrule formation region. Most heating events capable

  12. O ATLETISMO NA PERSPECTIVA EDUCACIONAL

    Directory of Open Access Journals (Sweden)

    Leandro Araujo de Sousa

    2017-06-01

    Full Text Available A educação física escolar deve proporcionar experiências aos alunos para o seu desenvolvimento integral. As aulas muitas vezes são reduzidas ao ensino de esportes tradicionais, o que limita o repertório de movimentos dos alunos. Dessa forma o presente estudo de revisão objetiva problematizar o atletismo no ambiente escolar e propor possibilidades pedagógicas para seu ensino. Nesta pesquisa propomos tratar o ensino do atletismo na escola, caracterizando-o pelo seu repertório de movimentos que são naturais ao ser humano, como correr, saltar e lançar, o que possibilita maior praticidade em sua aplicação pedagógica, porém essas possibilidades não são consideradas no ambiente educacional. Diante dos dados encontrados, sugerimos que esse esporte seja abordado de forma multidimensional no ambiente escolar contextualizando-o à visão de algumas correntes teóricas. Nessa perspectiva do esporte educacional, o atletismo pode, assim como deve ser trabalhado nas aulas de educação física como instrumento pedagógico de ensino e auxiliar na formação do aluno de forma global.

  13. Identidades Homossexuais na Territorialidade Tradicionalista

    Directory of Open Access Journals (Sweden)

    Edipo Djavan dos Reis Göergen

    2015-12-01

    Full Text Available Este artigo apresenta o debate teórico que sustenta a pesquisa de mestrado desenvolvida pelo autor. Tendo por base suas vivências em contextos de tradicionalismo gaúcho, o autor deste trabalho tem percebido a grande quantidade de homossexuais, ou indivíduos que se auto-denominam não-heterossexuais, integrando as atividades artísticas do Movimento Tradicionalista Gaúcho, ou a territorialidade tradicionalista. Interessado em investigar tal fenômeno, o autor tem desenvolvido o projeto de pesquisa “Os Espaços Paradoxais de Relações Homoeróticas na Territorialidade Tradicionalista”, sob orientação do prof. Dr. Benhur Pinós da Costa, no Programa de Pós-Graduação em Geografia (UFSM. Para que essa pesquisa seja realizada, levam-se em conta as relações de gênero e de sexualidade que estão envolvidas no tema. Dessa forma, por ainda se tratarem de temáticas tidas como insignificantes na sociedade em geral e marginalizadas no campo científico, para que o presente trabalho fosse empreendido, buscou-se amparo teórico nas geografias feministas e queer, segmentos contemporâneos da ciência geográfica.

  14. Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease

    DEFF Research Database (Denmark)

    Toustrup-Jensen, Mads Schak; Einholm, Anja P.; Schack, Vivien

    The neurological disorders familial hemiplegic migraine type 2 (FHM2), alternating hemiplegia of childhood (AHC), and rapid-onset dystonia parkinsonism (RDP) are caused by mutations of Na+,K+-ATPase α2 and α3 isoforms, expressed in glial and neuronal cells, respectively. Although these disorders......, addressing the question to what extent they cause a change of the intracellular Na+ and K+ concentrations ([Na+]i and [K+]i) in COS cells. C-terminal extension mutants generally showed dramatically reduced Na+ affinity without disturbance of K+ binding, as did other RDP mutants. No phosphorylation from ATP...

  15. Fotografia na Imprensa: conflitos na câmara escura

    Directory of Open Access Journals (Sweden)

    José Lúcio da Silva Menezes

    2014-07-01

    Full Text Available Este artigo recupera o teor ideológico do discurso que a Revista Veja elaborou sobre a classe trabalhadora que emergiu no cenário brasileiro, no final da década de 1970. O destaque dado aos trabalhadores como temática central resgatada, deve-se aos movimentos grevistas por eles encetados, após anos de ocultamento de sua resistência sob a repressão da ditadura civil-militar (1964-1985. Com a rebeldia operária, as matérias a respeito deste grupo, na Revista,foram se tornando mais constantes e visíveis, pois já não era mais possível, para a Revista Veja, ignorar a existência da classe operária que, com a força insurgente das greves, ocupava as ruas do Brasil.

  16. Uso da papaína na úlcera plantar

    OpenAIRE

    Otuka, Elizabet Shizue; Pedrazzani, Elisete Silva; Pioto, Mariangela Pedroso

    1996-01-01

    Este trabalho teve por objetivo contribuir para a diminuição da incapacidade em hanseníase e as contínuas recidivas de úceras plantares, através da utilização de um método de tratamento com o uso da papaína e ações de educação em saúde. Foi realizado em um Centro de Saúde com pacientes que apresentavam úcera plantar e que concordaram em participar do tratamento proposto. Analisando e comparando os dados obtidos antes e após o tratamento, concluímos que durante o tratamento foi observada uma m...

  17. Na and K dependence of the Na/K pump in cystic fibrosis fibroblasts.

    OpenAIRE

    Reznik, V M; Schneider, J A; Mendoza, S A

    1981-01-01

    The Na and K dependence of the Na/K pump was measured in skin fibroblasts from patients with cystic fibrosis and age/sex-matched controls. Under basal conditions, there was no difference between control and cystic fibrosis cells in protein per cell, intracellular Na and K content, or Na/K pump activity (measured as ouabain-sensitive 86Rb uptake). There was no difference in the Na dependence of the Na/K pump between cystic fibrosis cells and control cells. In cells from patients with cystic fi...

  18. Vpliv toplotnih mostov na porabo energije za ogrevanje na primeru osnovne šole

    OpenAIRE

    Megušar, Primož

    2015-01-01

    Na primeru Osnovne šole Dobrova sem preveril, kakšen vpliv imajo dejanski toplotni mostovi na porabo energije za ogrevanje. Iz načrtov stavbe sem evidentiral vse toplotne mostove, kateri vplivajo na porabo energije. Tem toplotnim mostovom sem nato v standardu SIST EN ISO 14683 poiskal ustrezne približke. Nato sem s programom TOST izvedel tri simulacije. V prvem primeru toplotnih mostov nisem upošteval. V drugem primeru sem toplotne mostove upošteval na poenostavljen način, v zadnjem primeru p...

  19. Low-spin states of 23Na

    International Nuclear Information System (INIS)

    Bakkum, E.L.

    1987-01-01

    A study of 23 Na via the 22 Ne(p,γ) 23 Na and 23 Na(γ,γ) 23 Na reactions is presented. Only a limited number of resonances has been studied, selected on the basis of strong excitation of the lowest levels of which the spin was unknown. As a result the spins are now known of all levels of 23 Na with excitation energies up to 7 MeV, except for a few high-spin states which are too weakly excited in the decay of the known 22 Ne(p,γ) resonances. The mean lifetimes of the 23 Na levels at 4.43 and 7.89 MeV were found to be 350±70 and 220±17 attoseconds (1 attosecond = 10 -18 seconds) respectively. 97 refs.; 22 figs.; 12 tabs

  20. PRIMERJAVA GEODETSKIH METOD NA ZAHTEVNEM GRADBENEM OBJEKTU

    OpenAIRE

    Reberčnik, Matic

    2017-01-01

    V projektni nalogi smo v uvodnih poglavjih predstavili različne načine izvajanja geodetskih meritev, ki jih v gradbeništvu uporabljamo pri analizi pomikov in deformacij gradbenih konstrukcij ter terena, na katerem so le-te postavljene. V nadaljevanju opisujemo terestične in GNSS (globalni navigacijski satelitski sistem) metode, ki smo jih uporabljali pri izvajanju meritev na izbranem premostitvenem objektu avtocestnega odseka v Sloveniji (zaradi varovanja podatkov ga imenujemo Objekt 1). Pod...

  1. Pioneering instrumentation aspects of NA60

    International Nuclear Information System (INIS)

    David, Andre

    2004-01-01

    NA60 is taking data with proton and heavy-ion beams at the CERN SPS. Although building up on previous experiments, the dimuon physics programme of NA60 places very demanding requirements on its new detectors, in terms of radiation tolerance, granularity and read-out electronics speed. We start by comparing dimuon detection strategies in NA60 with those of previous experiments. We then describe the new detectors used in NA60, placing particular emphasis on their technological pioneering aspects as well as on their contributions to the overall physics performance of the experiment

  2. Fabrication of implanted $^{22}$Na targets

    CERN Multimedia

    2002-01-01

    A knowledge of the $^{22}$Na(p,$\\gamma$)$^{23}$ Mg reaction rate is of significant astrophysical interest. In order to complete previous studies of this reaction, radioactive $^{22}$Na targets of high purity are required. We ask for support to fabricate these targets via the implantation technique at ISOLDE GPS (off—line mode) using $^{22}$Na nuclides in an Al matrix produced in Nov. 1990 at the PSI (Zürich). The $^{22}$Na nuclides are released and ionized in a surface ionisation source, mass-analyzed at ISOLDE GPS, and implanted in a Ni-Ta backing and a C—foil in a special implantation setup.

  3. OGLAŠEVANJE NA FACEBOOKU V SLOVENIJI

    OpenAIRE

    Dobnik, Monja

    2013-01-01

    Danes so zahvaljujoč napredni mobilni tehnologiji družbena omrežja z nami na vsakem koraku. Facebook (FB) se po priljubljenosti uvršča v sam vrh družbenih omrežij in glede na to, da ga uporablja že več kot milijarda zemljanov, ponuja tudi odlične trg za oglaševanje. To so ugotovili tudi slovenski podjetniki. V diplomski nalogi je predstavljeno, kako na FB oglašujejo nekatera slovenska podjetja, s pomočjo spletnega vprašalnika pa je ugotovljeno tudi, kaj o oglasih na FB menijo njegovi uporabni...

  4. Entrada vocabular na linguagem virtual

    OpenAIRE

    Macedo, Valdete Aparecida Xavier de [UNESP

    2002-01-01

    O objetivo deste trabalho foi o de fazer um estudo sobre a projeção do inglês, língua universal, sobre a portuguesa, considerando-se os empréstimos lexicais, porta de entrada para a configuração e enriquecimento vocabular da língua de chegada. Estes vocábulos são indicativos ao vocabulário da língua de especialidade, divulgados nos programas da Internet. Fizemos uma pequena reflexão sobre o fenômeno da linguagem virtual, que vem se cristalizando em discurso interativo de povos e nações coloca...

  5. Zbigniew Herbert, Znaki na papierze

    Directory of Open Access Journals (Sweden)

    Thibault Deleixhe

    2008-10-01

    Full Text Available Dans une interview, Zbigniew Herbert confiait : « Mon travail préparatoire à un livre, ce sont avant tout des dessins. Je ne fais pas de photos, cela simplifierait mon contact avec l’objet. » Il n’en fallait pas moins pour donner aux éditions Bosz l’envie d’un projet : réunir ces précieuses esquisses de travail et les confronter aux textes qui en sont nés. Le résultat s’intitule Znaki na papierze (Signes sur papier et appartient aux objets que l’on est fier de posséder dans sa bibliothèque. ...

  6. O consumo na vida digital

    Directory of Open Access Journals (Sweden)

    Iuri Yudi Furukita Baptista

    2016-02-01

    Full Text Available O modelo de consumo não possui as mesmas características sempre: suas relações, motivações, formatos, espaços, interesses e atividades são construções sociais que se modificam atreladas ao cenário econômico, político e tecnológico. O presente trabalho repassa o surgimento da sociedade do consumidor para então conjecturar sobre as propriedades distintivas do consumo na vida digital. O que se defende ao final é que o consumidor já não se restringe ao papel de consumir.

  7. Odpowiedź na pytanie

    Directory of Open Access Journals (Sweden)

    Michel Foucault

    2016-12-01

    Full Text Available Prezentowany artykuł Michela Foucaulta został opublikowany w 1963 roku. Foucault rozwija w nim koncepcję archeologii wiedzy – metody analizy historycznych dyskursów, którą zaprezentuje w sześć lat później w książce o tym właśnie tytule. Artykuł powstał na kanwie pytania wybranego przez autora spośród zadanych mu przez redakcję „Esprit”, które dotyczyło możliwości pojęciowego opracowania przymusu systemu dyskursywnego przy jednoczesnym zaakcentowaniu nieciągłości w jego obrębie a tym samym możliwości twórczego działania w historii ducha. A także, czy tak sformułowana aporia zakładałaby z konieczności zgodę na przymus systemu lub afirmację siły zdolnej do przekształcenia go za pomocą zewnętrznej przemocy? Tekst jest wprawką do sformułowania dojrzałej teorii dyskursu, rodzajem autoanalizy, która pozwala Foucaultowi powiązać własną metodę historyczną z „progresywistyczną polityką” myśli i rozwiązać w ten sposób dylemat pełnej determinacji i wolnego sprawstwa obecny w rozważaniach wielu strukturalistów.

  8. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart

    Science.gov (United States)

    Shattock, Michael J; Ottolia, Michela; Bers, Donald M; Blaustein, Mordecai P; Boguslavskyi, Andrii; Bossuyt, Julie; Bridge, John H B; Chen-Izu, Ye; Clancy, Colleen E; Edwards, Andrew; Goldhaber, Joshua; Kaplan, Jack; Lingrel, Jerry B; Pavlovic, Davor; Philipson, Kenneth; Sipido, Karin R; Xie, Zi-Jian

    2015-01-01

    This paper is the third in a series of reviews published in this issue resulting from the University of California Davis Cardiovascular Symposium 2014: Systems approach to understanding cardiac excitation–contraction coupling and arrhythmias: Na+ channel and Na+ transport. The goal of the symposium was to bring together experts in the field to discuss points of consensus and controversy on the topic of sodium in the heart. The present review focuses on cardiac Na+/Ca2+ exchange (NCX) and Na+/K+-ATPase (NKA). While the relevance of Ca2+ homeostasis in cardiac function has been extensively investigated, the role of Na+ regulation in shaping heart function is often overlooked. Small changes in the cytoplasmic Na+ content have multiple effects on the heart by influencing intracellular Ca2+ and pH levels thereby modulating heart contractility. Therefore it is essential for heart cells to maintain Na+ homeostasis. Among the proteins that accomplish this task are the Na+/Ca2+ exchanger (NCX) and the Na+/K+ pump (NKA). By transporting three Na+ ions into the cytoplasm in exchange for one Ca2+ moved out, NCX is one of the main Na+ influx mechanisms in cardiomyocytes. Acting in the opposite direction, NKA moves Na+ ions from the cytoplasm to the extracellular space against their gradient by utilizing the energy released from ATP hydrolysis. A fine balance between these two processes controls the net amount of intracellular Na+ and aberrations in either of these two systems can have a large impact on cardiac contractility. Due to the relevant role of these two proteins in Na+ homeostasis, the emphasis of this review is on recent developments regarding the cardiac Na+/Ca2+ exchanger (NCX1) and Na+/K+ pump and the controversies that still persist in the field. PMID:25772291

  9. Kinetin Reversal of NaCl Effects

    Science.gov (United States)

    Katz, Adriana; Dehan, Klara; Itai, Chanan

    1978-01-01

    Leaf discs of Nicotiana rustica L. were floated on NaCl in the presence of kinetin or abscisic acid. On the 5th day 14CO2 fixation, [3H]leucine incorporation, stomatal conductance, and chlorophyll content were determined. Kinetin either partially or completely reversed the inhibitory effects of NaCl while ABA had no effect. PMID:16660618

  10. Silicene for Na-ion battery applications

    KAUST Repository

    Zhu, Jiajie; Schwingenschlö gl, Udo

    2016-01-01

    Na-ion batteries are promising candidates to replace Li-ion batteries in large scale applications because of the advantages in natural abundance and cost of Na. Silicene has potential as the anode in Li-ion batteries but so far has not received

  11. Negative electrodes for Na-ion batteries.

    Science.gov (United States)

    Dahbi, Mouad; Yabuuchi, Naoaki; Kubota, Kei; Tokiwa, Kazuyasu; Komaba, Shinichi

    2014-08-07

    Research interest in Na-ion batteries has increased rapidly because of the environmental friendliness of sodium compared to lithium. Throughout this Perspective paper, we report and review recent scientific advances in the field of negative electrode materials used for Na-ion batteries. This paper sheds light on negative electrode materials for Na-ion batteries: carbonaceous materials, oxides/phosphates (as sodium insertion materials), sodium alloy/compounds and so on. These electrode materials have different reaction mechanisms for electrochemical sodiation/desodiation processes. Moreover, not only sodiation-active materials but also binders, current collectors, electrolytes and electrode/electrolyte interphase and its stabilization are essential for long cycle life Na-ion batteries. This paper also addresses the prospect of Na-ion batteries as low-cost and long-life batteries with relatively high-energy density as their potential competitive edge over the commercialized Li-ion batteries.

  12. Razvitak naselja na kvarnerskim otocima - primjer Dobrinja

    Directory of Open Access Journals (Sweden)

    Marijan Bradanović

    2012-12-01

    Full Text Available Na dosad slabo poznatom i sa stajališta povijesti umjetnosti još posve neobrađenom primjeru Dobrinja na otoku Krku, raspravlja se o razvitku naselja na kvarnerskim otocima. Uz isticanje štetnosti dosad prevladavajućih uopćavanja, karakteristični položaj i razvitak Dobrinja tumače se u širem, komparativnom kontekstu. Analiziraju se prostiranje i obilježja pojedinih dijelova ovog naselja, a naglasak je na vremenu kasnog srednjeg i ranijeg novog vijeka. Tada je najuži dio povijesnog središta Dobrinja poprimio čvrstu, na tlorisnoj osnovi i danas, usprkos opsežnim pregradnjama i arhitektonskim preinakama, jasno uočljivu, urbanu fizionomiju.

  13. Bullying na Escola: um sofrimento

    Directory of Open Access Journals (Sweden)

    Marlene Silva Sardinha Gurpilhares

    2014-07-01

    Full Text Available O bullying é uma forma de violência presente nas escolas e o termo é utilizado para caracterizar todas as formas de agressões repetitivas psicológicas e físicas, direta ou indiretamente. Esta violência causa sofrimentos, intimidação e medo, sempre numa relação de poder entre pares. Esta pesquisa trata de um estudo do bullying escolar: o que é, como surgiu, como identificá-lo e sua caracterização, conseqüências, causas, o papel da escola, de professores e pais e uma proposta prática que pode ser adotada para sua prevenção e contenção. O objetivo é organizar materiais para leitura dos atores educacionais para uma possível reflexão, através de pesquisas bibliográficas. Esta violência é grave e deveria ser tratada como saúde pública, devido às conseqüências que traz, como queda na aprendizagem, na autoestima e em casos mais graves, até o suicido e outras tragédias. A escola necessita atentar para esse tipo de violência, revendo suas ações em todos os momentos, tendo um olhar integral e diferenciado em relação aos alunos. É fundamental que o bullying não seja tratado como brincadeira de criança e para ser identificado e combatido é necessária uma ação entre a família e todos da escola, que pode ser desenvolvida através de projetos que ajudem a apontar caminhos para a solução do problema. Tais ações devem ser pautadas por constantes debates e reflexões, nas quais o aluno se torne o protagonista. Não existem fórmulas prontas, pois a intervenção deve ser feita através da realidade de cada escola.

  14. Study of the Na-C-O and Na-H-O ternary systems in the sodium rich corner

    International Nuclear Information System (INIS)

    Maupre, J.-P.

    1978-02-01

    The purpose of this study is to provide a contribution to the understanding of the sodium - carbon - oxygen and sodium - hydrogen - oxygen ternary systems in the sodium rich corner. In order to do this the Na-NaH-Na 2 O-NaOH phase diagram was completed and the Na-Na 2 O-Na 2 CO 3 -C phase diagram was outlined. This work is made up of two parts. The first is devoted to a critical literature survey essential to establish correct phase diagrams. The second is an experimental study followed by a discussion collating our finding to the literary data. The basic experimental technique used is differential thermal analysis (DTA) but it has been completed by quenching, X-ray and chemical analysis methods. The proposed phase diagrams imply that Na-NaH-Na 2 O-NaOH and Na-Na 2 O-Na 2 CO 3 -C systems are reciprocal ternary systems. Temperatures of stable pairs reversal are respectively 410 and 690 0 C. The stable pairs are Na-NaOH and Na-Na 2 CO 3 at elevated temperature, Na 2 O-NaH and Na 2 O-C at low temperature [fr

  15. OGLAŠEVANJE NA DRUŽBENIH OMREŽJIH NA PRIMERU FACEBOOKA

    OpenAIRE

    Novak, Martina

    2012-01-01

    V diplomskem delu obravnavamo družbene medije kot novo priložnost za promocijo in oglaševanje podjetij. Spoznali smo družbena omrežja na splošno in nekaj teh, ki jih uporabljamo tudi v Sloveniji na kratko predstavili. Podrobneje smo se osredotočili na družbeno omrežje Facebook, predvsem na samo spletno stran, njen izgled in storitve, ki jih ponuja uporabnikom. V nalogi je podrobneje opisan Facebook kot orodje za uporabo oglaševanja. Spoznali smo brezplačne in plačljive načine promocije in ogl...

  16. Terapia de linguagem na afasia

    Directory of Open Access Journals (Sweden)

    Mauro Spinelli

    1977-12-01

    Full Text Available A terapia da linguagem na afasia foi estudada em 15 pacientes, 8 do sexo masculino e 7 do sexo feminino; a idade variou de menos de 10 anos a mais de 50 anos; em 11 casos a afasia era sequela de acidente vascular cerebral e, em 4, de traumatismo crânio-encefálico. Quanto ao tipo de afasia, 5 pacientes apresentavam déficits predominantemente de expressão e 10 apresentavam déficits receptivos e expressivos em graus equiparáveis. Em 6 casos a terapia foi iniciada dentro dos 3 primeiros meses de instalação do quadro; nos restantes foi iniciada mais tardiamente. Dos 15 pacientes, 11 apresentaram evolução satisfatória, a qual não depndeu do grau de afasia, do tipo de afasia, da idade do paciente, do tipo de patologia e do intervalo entre a instalação do quadro afásico e o início da terapia. A terapia da linguagem no paciente afásico é efetiva, o prognóstico não pode ser feito a priori. Somente a evolução do caso com sua retestagem criteriosa poderá dar dados realmente úteis para se falar em evolução.

  17. Extracellular Na+ levels regulate formation and activity of the NaX/alpha1-Na+/K+-ATPase complex in neuronal cells.

    Directory of Open Access Journals (Sweden)

    Emmanuelle eBerret

    2014-12-01

    Full Text Available MnPO neurons play a critical role in hydromineral homeostasis regulation by acting as sensors of extracellular sodium concentration ([Na+]out. The mechanism underlying Na+-sensing involves Na+-flow through the NaX channel, directly regulated by the Na+/K+-ATPase α1-isoform which controls Na+-influx by modulating channel permeability. Together, these two partners form a complex involved in the regulation of intracellular sodium ([Na+]in. Here we aim to determine whether environmental changes in Na+ could actively modulate the NaX/Na+/K+-ATPase complex activity.We investigated the complex activity using patch-clamp recordings from rat MnPO neurons and Neuro2a cells. When the rats were fed with a high-salt-diet, or the [Na+] in the culture medium was increased, the activity of the complex was up-regulated. In contrast, drop in environmental [Na+] decreased the activity of the complex. Interestingly under hypernatremic condition, the colocalization rate and protein level of both partners were up-regulated. Under hyponatremic condition, only NaX protein expression was increased and the level of NaX/Na+/K+-ATPase remained unaltered. This unbalance between NaX and Na+/K+-ATPase pump proportion would induce a bigger portion of Na+/K+-ATPase-control-free NaX channel. Thus we suggest that hypernatremic environment increases NaX/Na+/K+-ATPase α1-isoform activity by increasing the number of both partners and their colocalization rate, whereas hyponatremic environment down-regulates complex activity via a decrease in the relative number of NaX channels controlled by the pump.

  18. Artesanato na terceira idade: um estudo na cidade de Sinop

    Directory of Open Access Journals (Sweden)

    Rosane Marlene Weber

    2012-06-01

    Full Text Available O presente artigo sobre o artesanato e a Terceira Idade, pesquisa realizada em 2011, teve como metodologia o Estudo de Caso do tipo etnográfico. A metodologia de investigação ocorreu por meio de entrevistas semiestruturadas, orais e transcritas, observação e fotografias dos artesanatos em locais de venda e nas residências dos artesãos. Os sujeitos da pesquisa foram: a presidente da Associação da Casa do Artesão de Sinop-MT e oito artesãos. O objetivo foi mostrar a importância do artesanato como atividade educacional e como produtora de autonomia e autoria para os artesãos da Terceira Idade, motivados em realizar este trabalho nesta fase da vida. Para o embasamento teórico utilizou-se obras de Paulo Freire, Moacir Gadotti e sobre a Terceira Idade a coleção de Vivaidade com a organizadora Anita Liberalesso Neri. A análise das entrevistas mostrou que o artesanato traz autonomia educacional quando o idoso busca sozinho aprender sobre o objeto a ser realizado, assim como autonomia financeira, uma vez que a venda do artesanato proporciona certa independência econômica. Em relação ao sentimento de autoria das peças criadas constatou-se muita satisfação e realização, o que motiva a continuar sendo úteis e produtivos na Terceira Idade com muita criatividade. Palavras-chave: educação; terceira idade; artesanato; autonomia; autoria.

  19. Glutamate Water Gates in the Ion Binding Pocket of Na(+) Bound Na(+), K(+)-ATPase

    DEFF Research Database (Denmark)

    Han, Minwoo; Kopec, Wojciech; Solov'yov, Ilia A

    2017-01-01

    III is always protonated. Glutamic acid residues in the three binding sites act as water gates, and their deprotonation triggers water entry to the binding sites. From DFT calculations of Na(+) binding energies, we conclude that three protons in the binding site are needed to effectively bind Na......The dynamically changing protonation states of the six acidic amino acid residues in the ion binding pocket of the Na(+), K(+) -ATPase (NKA) during the ion transport cycle are proposed to drive ion binding, release and possibly determine Na(+) or K(+) selectivity. We use molecular dynamics (MD......(+) from water and four are needed to release them in the next step. Protonation of Asp926 in site III will induce Na(+) release, and Glu327, Glu954 and Glu779 are all likely to be protonated in the Na(+) bound occluded conformation. Our data provides key insights into the role of protons in the Na...

  20. Crystal structure of Na+, K(+)-ATPase in the Na(+)-bound state.

    Science.gov (United States)

    Nyblom, Maria; Poulsen, Hanne; Gourdon, Pontus; Reinhard, Linda; Andersson, Magnus; Lindahl, Erik; Fedosova, Natalya; Nissen, Poul

    2013-10-04

    The Na(+), K(+)-adenosine triphosphatase (ATPase) maintains the electrochemical gradients of Na(+) and K(+) across the plasma membrane--a prerequisite for electrical excitability and secondary transport. Hitherto, structural information has been limited to K(+)-bound or ouabain-blocked forms. We present the crystal structure of a Na(+)-bound Na(+), K(+)-ATPase as determined at 4.3 Å resolution. Compared with the K(+)-bound form, large conformational changes are observed in the α subunit whereas the β and γ subunit structures are maintained. The locations of the three Na(+) sites are indicated with the unique site III at the recently suggested IIIb, as further supported by electrophysiological studies on leak currents. Extracellular release of the third Na(+) from IIIb through IIIa, followed by exchange of Na(+) for K(+) at sites I and II, is suggested.

  1. ASSESSMENT OF PLASMA ZINC STATUS OF SENILE CATARACT ...

    African Journals Online (AJOL)

    ... AND NON-CATARACT ELDERLY PATIENTS IN MID-WESTERN NIGERIA- A CASE ... which may occur in zinc deficiency even with normal vitamin A status. ... La présente étude a pour objet d\\'évaluer le niveau de zinc chez les malades ...

  2. Iran: Economy, Senility, and Ineptitude Greasing the Slide to Instability.

    Science.gov (United States)

    1986-01-13

    Business 5 Foreign Trade 6 Political Developments 8 Industry 10 Finance 12 Inflation 13 Rationing 14 Countertrade 16 Oil 17 War With Iraq 18 Outlook 20...imposed diplomatic isolation and threatening revolutionary rhetoric discourage foreign budgetary or balance of payments assistance. Countertrade : In...order to obtain these goods and services while reducing foreign exchange expenditures, Iran has expanded the use of barter and countertrade . Barter

  3. SENILE DEGENERATIVE CHANGES IN ADULT LUMBAR SPINE! - A PROSPECTIVE STUDY

    Directory of Open Access Journals (Sweden)

    Garjesh Singh

    2015-11-01

    Full Text Available : BACKGROUND: Low back pain (LBP is a common presenting complaint affecting mostly middle aged and older person and traditionally considered as ageing process, but now-a-days large number of younger people are also affected by this debilitating chronic disorder. The cause of early onset of degenerative spine disease is multifactorial, but genetical predisposition plays very important role. AIMS AND OBJECTIVE: To find out association between genetic predisposition and degenerative spine disease in adult patients and to assess the pattern of MRI findings of various degenerative diseases in lumbo-sacral spine. MATERIAL AND METHOD: The present cross-sectional study had been performed among 100 selected patients in 1yr period, who presented with chief complaint of chronic low back pain. After taking detailed clinical and professional history, MRI of lumbosacral spine had been performed. Total 100 patients were divided in two groups on the basis of genetical predisposition. Prevalence and spectrum of degenerative changes were compared between both groups. RESULTS: Hundred patients of 20 to 35-year age had been selected with mean age of 27yr. Out of 100 patients; 47 were male and 53 were female. The most common degenerative findings were desiccation of disc (95% followed by disc bulge, herniation, spinal canal stenosis, ligamentum flavum hypertrophy, facet joint hypertrophy and modic changes. L4-L5 and L5- S1 were the most commonly involved spinal levels for any degenerative pathology. CONCLUSION: Good association is seen between early onset of degenerative spine disease and genetical predisposition in patients who have history of similar type degenerative spine disease in one or more first degree relatives in comparison to those patients who do not have any genetical predisposition. So it can be concluded that heredity play important role in early onset of degenerative spine disease in adults.

  4. Role of lipid peroxidation in pathogenesis of senile cataract

    Directory of Open Access Journals (Sweden)

    Kisić Bojana

    2009-01-01

    Full Text Available Background /Aim. Cataract is a structural, biochemical and optical change in the eye lens, which changes transmission and refraction of light rays reducing keenness and clarity of a figure on the retina. Its occurrence is highest in older people, over the age of 65 (45.9%, thus a certain degree of opacification exists practically in all people over the 70. Our research was directed to measuring of lipid peroxidation products in cataract lenses involved in early stages of cataractogenesis through oxidative stress and in the development of mature cataract. Methods. Clinical and biochemical research was carried out in 101 patients with cataract, 46 women and 55 men. The average age of the group was 72.47 (ґ = 7.98. According to the cataract maturity degree the patients were classified into two groups as follows: cataracta senilis incipiens (n = 41 and cataracta senilis matura (n = 60. Measuring of diene conjugates was carried out by spectrophotometer. Fluorescent lipid peroxidation products were measured by a spectrofluorophotometer, and malondialdehyde (MDA concentration was measured by colorimeter as a product of a reaction with thiobarbituric acid (TBA. Result. Significantly higher diene conjugated concentration in lenses was measured in the patients with the diagnosis cataracta senilis incipiens (p < 0.001 as well as the intensity of fluorescent iminopropens (p < 0.001. Significantly higher MDA concentration in lens (p < 0.001 was measured in the patients with cataracta senilis matura. Conclusion. The lens structure changes caused by lipid peroxidation can, with other risk factors present, influence the occurrence and development of mature cataract. Some cataract types show different lipid peroxidation intensity with the most distinct changes in cataract which started as corticonuclear.

  5. Role of brain imaging for diagnosis of senile dementia

    Energy Technology Data Exchange (ETDEWEB)

    Nishino, Hideo

    1988-12-01

    X-ray computed tomography (CT) was performed in a total of 239 patients, consisting of 100 with dementia and 139 normal volunteers. In the normal group, small infarcted areas were observed in 20%, and dilatation of the lateral ventricle, cerebral sulci and Sylvian fissure was associated with aging. In the dementia group, the incidence of periventricular lucency was closely related to cerebrovascular disorder, and also increased with aging for Alzheimer type dimentia; dilatation of the lateral ventricle, cerebral sulci, Sylvian fissure, and third ventricle was unrelated to aging; the incidence of dilated lateral ventricle and Sylvian fissure was frequently observed when cerebrovascular disorder was associated; an atrophied medial temporal lobe was observed in patients with presenile dementia under the age of 60. Radionuclide cisternography for 145 patients with various diseases and 56 normal subjects revealed: ventricular reflux was observed in 50% of the total cases; it occurred in 50% in each group with either cerebrovascular disorder or non-cerebrovascular disorder; persistent ventricular reflux with Sylvian block was observed in 40% of cases of subarachnoid hemorrhage; and ventricular reflux in the elderly was considered attributable to pseudo-normal pressure hydrocephalus. Single photon emission computed tomography with I-123 IMP, performed in 11 dementia and 5 non-dementia patients, revealed a decreased uptake in the temporo-parietal region only in cases of Alzheimer type dementia, although there was no abnormal X-ray CT finding. (Namekawa, K) 51 refs.

  6. The role of brain imaging for diagnosis of senile dementia

    International Nuclear Information System (INIS)

    Nishino, Hideo

    1988-01-01

    X-ray computed tomography (CT) was performed in a total of 239 patients, consisting of 100 with dementia and 139 normal volunteers. In the normal group, small infarcted areas were observed in 20%, and dilatation of the lateral ventricle, cerebral sulci and Sylvian fissure was associated with aging. In the dementia group, the incidence of periventricular lucency was closely related to cerebrovascular disorder, and also increased with aging for Alzheimer type dimentia; dilatation of the lateral ventricle, cerebral sulci, Sylvian fissure, and third ventricle was unrelated to aging; the incidence of dilated lateral ventricle and Sylvian fissure was frequently observed when cerebrovascular disorder was associated; an atrophied medial temporal lobe was observed in patients with presenile dementia under the age of 60. Radionuclide cisternography for 145 patients with various diseases and 56 normal subjects revealed: ventricular reflux was observed in 50% of the total cases; it occurred in 50% in each group with either cerebrovascular disorder or non-cerebrovascular disorder; persistent ventricular reflux with Sylvian block was observed in 40% of cases of subarachnoid hemorrhage; and ventricular reflux in the elderly was considered attributable to pseudo-normal pressure hydrocephalus. Single photon emission computed tomography with I-123 IMP, performed in 11 dementia and 5 non-dementia patients, revealed a decreased uptake in the temporo-parietal region only in cases of Alzheimer type dementia, although there was no abnormal X-ray CT finding. (Namekawa, K) 51 refs

  7. Prevalence de la cataracte senile dans une population rurale du ...

    African Journals Online (AJOL)

    But: Evaluer la prévalence de la cataracte sénile dans le canton de Kévé, préfecture de l'Avé au Togo. Méthodologie: Il s'agit d'une étude transversale dans trois villages et le centre ville de Kévé. Les patients étaient regroupés et examinés à la lumière du jour à l'aide d'une lampe torche et un ophtalmoscope direct à piles ...

  8. Laser-induced ionization of Na vapor

    International Nuclear Information System (INIS)

    Wu, R.C.Y.; Judge, D.L.; Roussel, F.; Carre, B.; Breger, P.; Spiess, G.

    1982-01-01

    The production of Na 2 + ions by off-resonant laser excitation in the 5800-6200A region mainly results from two-photon absorption by the Na 2 molecule to highly excited gerade states followed by (a) direct ionization by absorbing a third photon or (b) coupling to the molecular Na 2 D 1 PIμ Rydberg state which is subsequently ionized by absorbing a third photon. This mechanism, i.e., a two-photon resonance three photon ionization process, explains a recent experimental observation of Roussel et al. It is suggested that the very same mechanism is also responsible for a similar observation reported by Polak-Dingels et al in their work using two crossed Na beams. In the latter two studies the laser-induced associative ionization processes were reported to be responsible for producing the Na 2 + ion. From the ratio of molecular to atomic concentration in the crossed beam experiment of Polak-Dingels et al we estimate that the cross section for producing Na 2 + through laser-induced associative ionization is at least four orders of magnitude smaller than ionization through the two-photon resonance three photon ionization process in Na 2 molecules

  9. NaK handling and removal

    International Nuclear Information System (INIS)

    Desreumaux, J.; Rodriguez, G.; Guigon, A.; Verdelli, J.; Thomine, G.

    1997-01-01

    Sodium-potassium alloy is used in specific application in French Fast Breeder Reactors as: cold traps, NaK bubbler for argon purification, valves and also in experimental irradiation devices. lt has been preferred to sodium because it is liquid from + 7 deg. C for the most common peritectic alloy. After its use, NaK is considered as a hazardous waste (nuclear or not) due to its high reactivity with air and water. The most important risk remains in handling NaK systems which have not been operated for some time. The NaK will be covered with a crust of the superoxide K02 which is a strong oxidising agent. Thermodynamically, K02 will react with most organic material or metallic dust or swarfs and can also react with additional NaK to give sufficient heat to boil part of the NaK, resulting in a sudden increase in pressure and small explosions. We describe the formation given to experimenters in our Sodium School and the CEA's experience in treating specific devices for transportation, decanting of tanks, tank opening and NaK removal. (author)

  10. Na/K pump inactivation, subsarcolemmal Na measurements, and cytoplasmic ion turnover kinetics contradict restricted Na spaces in murine cardiac myocytes

    OpenAIRE

    Lu, Fang-Min; Hilgemann, Donald W.

    2017-01-01

    The Na/K pump exports cytoplasmic Na ions while importing K ions, and its activity is thought to be affected by restricted intracellular Na diffusion in cardiac myocytes. Lu and Hilgemann find instead that the pump can enter an inactivated state and that inactivation can be relieved by cytoplasmic Na.

  11. MODELI MERJENJA KAKOVOSTI STORITEV NA MEDORGANIZACIJSKEM TRGU

    OpenAIRE

    Cestnik, Dušan

    2011-01-01

    Vse večja konkurenca na medorganizacijskih trgih sili tako storitvena podjetja, kot tudi podjetja, ki tržijo izdelke, da svoje delo opravljajo vse bolj kakovostno na vseh ravneh svojega delovanja. Podjetja morajo svoje odjemalce obdržati, prav tako pa morajo delovati tudi na pridobivanju novih odjemalcev. Da pa podjetja svoje odjemalce obdržijo morajo nenehno delovati tako, da uživajo zaupanje svojih odjemalcev. Odjemalec že z odločitvijo za neko določeno podjetje XY pričakuje, da bodo storit...

  12. Na+,K+ pumpen vedbliver at overraske

    DEFF Research Database (Denmark)

    Vilsen, Bente

    2008-01-01

    This article provides an overview of news about the Na+,K+ pump, an indispensable enzyme whose protein structure has been described in a recent article in Nature, 50 years after its discovery. In combination with mutational analysis, the structure reveals the binding pocket for the K+ ions...... and the regulation of Na+ transport by a strategically located C-terminus of the protein. Focus is also on the pathophysiology of two neurological disorders, familial hemiplegic migraine and rapid-onset dystonia-parkinsonism, recently shown to be caused by mutations in the Na+,K+-ATPase. Udgivelsesdato: may 19...

  13. Myocardial Na,K-ATPase: Clinical aspects

    Science.gov (United States)

    Kjeldsen, Keld

    2003-01-01

    The specific binding of digitalis glycosides to Na,K-ATPase is used as a tool for Na,K-ATPase quantification with high accuracy and precision. In myocardial biopsies from patients with heart failure, total Na,K-ATPase concentration is decreased by around 40%; a correlation exists between a decrease in heart function and a decrease in Na,K-ATPase concentration. During digitalization, around 30% of remaining pumps are occupied by digoxin. Myocardial Na,K-ATPase is also influenced by other drugs used for the treatment of heart failure. Thus, potassium loss during diuretic therapy has been found to reduce myocardial Na,K-ATPase, whereas angiotensin-converting enzyme inhibitors may stimulate Na,K pump activity. Furthermore, hyperaldosteronism induced by heart failure has been found to decrease Na,K-ATPase activity. Accordingly, treatment with the aldosterone antagonist, spironolactone, may also influence Na,K-ATPase activity. The importance of Na,K pump modulation with heart disease, inhibition in digitalization and other effects of medication should be considered in the context of sodium, potassium and calcium regulation. It is recommended that digoxin be administered to heart failure patients who, after institution of mortality-reducing therapy, still have heart failure symptoms, and that the therapy be continued if symptoms are revealed or reduced. Digitalis glycosides are the only safe inotropic drugs for oral use that improve hemodynamics in heart failure. An important aspect of myocardial Na,K pump affection in heart disease is its influence on extracellular potassium (Ke) homeostasis. Two important aspects should be considered: potassium handling among myocytes, and effects of potassium entering the extracellular space of the heart via the bloodstream. It should be noted that both of these aspects of Ke homeostasis are affected by regulatory aspects, eg, regulation of the Na,K pump by physiological and pathophysiological conditions, as well as by medical

  14. Nalaz tombusvirusa na vrsti Erigeron canadensis L.

    OpenAIRE

    Jeknić, Zoran; Erić, Živojin; Grbelja, Julijana

    1988-01-01

    Iz listova zaraženih primjeraka korovne biljke Erigeron canadensis L. koji su rasli na nekoliko lokaliteta u Sarajevu izoliran je virus iz skupine tombusvirusi. Identifikacija virusa izvršena je na osnovi reakcije pokusnih biljaka, analize ultratankih presjeka kroz zaraženo tkivo, morfologije i veličine virusnih čestica, te na osnovi seroloških reakcija metodom dvostruke imunodifuzije u agarskom gelu i čvrsto fazne imunoelektronske mikroskopije (SPIEM). U serološkim pokusima upotrijebljen je ...

  15. Glutathionylation-Dependence of Na+-K+-Pump Currents Can Mimic Reduced Subsarcolemmal Na+ Diffusion

    Science.gov (United States)

    Garcia, Alvaro; Liu, Chia-Chi; Cornelius, Flemming; Clarke, Ronald J.; Rasmussen, Helge H.

    2016-01-01

    The existence of a subsarcolemmal space with restricted diffusion for Na+ in cardiac myocytes has been inferred from a transient peak electrogenic Na+-K+ pump current beyond steady state on reexposure of myocytes to K+ after a period of exposure to K+-free extracellular solution. The transient peak current is attributed to enhanced electrogenic pumping of Na+ that accumulated in the diffusion-restricted space during pump inhibition in K+-free extracellular solution. However, there are no known physical barriers that account for such restricted Na+ diffusion, and we examined if changes of activity of the Na+-K+ pump itself cause the transient peak current. Reexposure to K+ reproduced a transient current beyond steady state in voltage-clamped ventricular myocytes as reported by others. Persistence of it when the Na+ concentration in patch pipette solutions perfusing the intracellular compartment was high and elimination of it with K+-free pipette solution could not be reconciled with restricted subsarcolemmal Na+ diffusion. The pattern of the transient current early after pump activation was dependent on transmembrane Na+- and K+ concentration gradients suggesting the currents were related to the conformational poise imposed on the pump. We examined if the currents might be accounted for by changes in glutathionylation of the β1 Na+-K+ pump subunit, a reversible oxidative modification that inhibits the pump. Susceptibility of the β1 subunit to glutathionylation depends on the conformational poise of the Na+-K+ pump, and glutathionylation with the pump stabilized in conformations equivalent to those expected to be imposed on voltage-clamped myocytes supported this hypothesis. So did elimination of the transient K+-induced peak Na+-K+ pump current when we included glutaredoxin 1 in patch pipette solutions to reverse glutathionylation. We conclude that transient K+-induced peak Na+-K+ pump current reflects the effect of conformation-dependent β1 pump subunit

  16. Altered Na+ transport after an intracellular alpha-subunit deletion reveals strict external sequential release of Na+ from the Na/K pump.

    Science.gov (United States)

    Yaragatupalli, Siddhartha; Olivera, J Fernando; Gatto, Craig; Artigas, Pablo

    2009-09-08

    The Na/K pump actively exports 3 Na(+) in exchange for 2 K(+) across the plasmalemma of animal cells. As in other P-type ATPases, pump function is more effective when the relative affinity for transported ions is altered as the ion binding sites alternate between opposite sides of the membrane. Deletion of the five C-terminal residues from the alpha-subunit diminishes internal Na(+) (Na(i)(+)) affinity approximately 25-fold [Morth et al. (2007) Nature 450:1043-1049]. Because external Na(+) (Na(o)(+)) binding is voltage-dependent, we studied the reactions involving this process by using two-electrode and inside-out patch voltage clamp in normal and truncated (DeltaKESYY) Xenopus-alpha1 pumps expressed in oocytes. We observed that DeltaKESYY (i) decreased both Na(o)(+) and Na(i)(+) apparent affinities in the absence of K(o)(+), and (ii) did not affect apparent Na(o)(+) affinity at high K(o)(+). These results support a model of strict sequential external release of Na(+) ions, where the Na(+)-exclusive site releases Na(+) before the sites shared with K(+) and the DeltaKESYY deletion only reduces Na(o)(+) affinity at the shared sites. Moreover, at nonsaturating K(o)(+), DeltaKESYY induced an inward flow of Na(+) through Na/K pumps at negative potentials. Guanidinium(+) can also permeate truncated pumps, whereas N-methyl-D-glucamine cannot. Because guanidinium(o)(+) can also traverse normal Na/K pumps in the absence of both Na(o)(+) and K(o)(+) and can also inhibit Na/K pump currents in a Na(+)-like voltage-dependent manner, we conclude that the normal pathway transited by the first externally released Na(+) is large enough to accommodate guanidinium(+).

  17. Erythrocyte 22Na+ influx in hypertension

    International Nuclear Information System (INIS)

    Shalev, O.; Eaton, J.W.; Ben-Ishay, D.

    1984-01-01

    We assessed 22Na+ uptake by erythrocytes (RBC) from 38 individuals with essential hypertension and 37 healthy controls. All subjects were male, white, non-obese and with normal renal function, obviating sex, race, hormonal, ponderal and renal factors known to influence RBC Na+ handling. The mean +/- sem 22Na+ uptake of the patients was 284 +/- 16 mumole/liter RBC/hour while that of normal controls was 249 +/- 11 mumole/liter RBC/hour; although the difference reached borderline significance, individual values showed considerable overlap. Consequently, in our population, RBC 22Na+ uptake is not a reliable marker for essential hypertension. We believe that previous studies should be reassessed with regard to patients' characteristics and future studies employ rigorous criteria in selection of subjects

  18. Painful Na-channelopathies: an expanding universe.

    Science.gov (United States)

    Waxman, Stephen G

    2013-07-01

    The universe of painful Na-channelopathies--human disorders caused by mutations in voltage-gated sodium channels--has recently expanded in three dimensions. We now know that mutations of sodium channels cause not only rare genetic 'model disorders' such as inherited erythromelalgia and channelopathy-associated insensitivity to pain but also common painful neuropathies. We have learned that mutations of NaV1.8, as well as mutations of NaV1.7, can cause painful Na-channelopathies. Moreover, recent studies combining atomic level structural models and pharmacogenomics suggest that the goal of genomically guided pain therapy may not be unrealistic. Copyright © 2013 Elsevier Ltd. All rights reserved.

  19. Usmerjanje urbanega razvoja na mestni ravni

    Directory of Open Access Journals (Sweden)

    Mojca Šašek Divjak

    1999-01-01

    Full Text Available Kot je poudarjeno v predstavljenem načrtu Kopenhagna, mestni načrt ne more rešiti vseh planskih problemov mesta. Predstavljal naj bi predvideni red, ki pa se pogosto sproti podira glede na nepredvidena dogajanja v prostoru. Probleme je velikokrat treba reševati šele, ko se pokažejo. Zato mora biti mestni načrt zastavljen dovolj prilagodljivo in fleksibilno, da dovoljuje potrebne spremembe. Vendar mora kljub temu dati mestu trdne glavne usmeritve in s tem omogočiti, da meščani lahko izkoristijo priložnosti, ki jih nudi nova doba in uveljavljajo nove kvalitete bivanja.

  20. Na+-H+ exchange and Na+-dependent transport systems in streptozotocin diabetic rat kidneys

    International Nuclear Information System (INIS)

    El-Seifi, S.; Freiberg, J.M.; Kinsella, F.J.; Cheng, L.; Sacktor, B.

    1987-01-01

    The streptozotocin-induced diabetic rat was used to test the hypothesis that Na + -H + exchange activity in the proximal tubule luminal membrane would be increased in association with renal hypertrophy, altered glomerular hemodynamics, enhanced filtered load and tubular reabsorption of 22 Na + , and stimulated 22 Na= pump activity in the basolateral membrane, previously reported characteristics of this experimental animal model. Amiloride-sensitive H + gradient-dependent Na + uptake and Na + gradient-dependent H + flux were increased in brush-border membrane vesicles from the streptozotocin-treated animals. Na + gradient-dependent uptakes of phosphate, D-glucose, L-proline, and myoinositol were decreased in the drug-induced diabetic animals. These membrane transport alterations were not found when the streptozotocin-diabetic animals were treated with insulin

  1. Effects of EDTA-Na (Na ethylenediaminetetraacetate) upon the metabolism of radiostrontium and radioyttrium in mice

    Energy Technology Data Exchange (ETDEWEB)

    Kikuchi, T; Wakisaka, G; Kono, T; Hiroaki, A; Yamamasu, T; Sugawa, I

    1954-01-01

    The toxicity of EDTA-Na, inert Sr (NO/sub 3/)/sub 2/ and Ba (NO/sub 3/)/sub 2/ has been examined. Simultaneous injection of EDTA-Na showed no significant effect upon the distribution of radio-Sr in the bones of mice. The distribution of radio-Y in the bones of mice tended to decrease following the simultaneous subcutaneous injection of /sup 91/Y and EDTA-Na.

  2. Glutathionylation-Dependence of Na+-K+-Pump Currents Can Mimic Reduced Subsarcolemmal Na+ Diffusion

    OpenAIRE

    Garcia, Alvaro; Liu, Chia-Chi; Cornelius, Flemming; Clarke, Ronald?J.; Rasmussen, Helge?H.

    2016-01-01

    The existence of a subsarcolemmal space with restricted diffusion for Na+ in cardiac myocytes has been inferred from a transient peak electrogenic Na+-K+ pump current beyond steady state on reexposure of myocytes to K+ after a period of exposure to K+-free extracellular solution. The transient peak current is attributed to enhanced electrogenic pumping of Na+ that accumulated in the diffusion-restricted space during pump inhibition in K+-free extracellular solution. However, there are no know...

  3. NA62 and NA48/2 results on search for Heavy Neutral Leptons

    Directory of Open Access Journals (Sweden)

    Lamanna Gianluca

    2018-01-01

    Full Text Available In this paper we present new results on upper limits for the search of Heavy Neutral Leptons (HNL with data collected by NA48/2 (2003-2004, NA62-RK (2007 and NA62 (2015 CERN experiments. The data collected with different trigger configuration allow to search for both long and short living heavy neutrinos in the mass range below the kaon mass. In addition the status of the search for K+ → π+vv with the NA62 detector will be briefly presented.

  4. Interaction between Na+/K+-pump and Na+/Ca2+-exchanger modulates intercellular communication.

    Science.gov (United States)

    Matchkov, Vladimir V; Gustafsson, Helena; Rahman, Awahan; Briggs Boedtkjer, Donna M; Gorintin, Sarah; Hansen, Anne Kirstine; Bouzinova, Elena V; Praetorius, Helle A; Aalkjaer, Christian; Nilsson, Holger

    2007-04-13

    Ouabain, a specific inhibitor of the Na(+)/K(+)-pump, has previously been shown to interfere with intercellular communication. Here we test the hypothesis that the communication between vascular smooth muscle cells is regulated through an interaction between the Na(+)/K(+)-pump and the Na(+)/Ca(2+)-exchanger leading to an increase in the intracellular calcium concentration ([Ca(2+)](i)) in discrete areas near the plasma membrane. [Ca(2+)](i) in smooth muscle cells was imaged in cultured rat aortic smooth muscle cell pairs (A7r5) and in rat mesenteric small artery segments simultaneously with force. In A7r5 coupling between cells was estimated by measuring membrane capacitance. Smooth muscle cells were uncoupled when the Na(+)/K(+)-pump was inhibited either by a low concentration of ouabain, which also caused a localized increase of [Ca(2+)](i) near the membrane, or by ATP depletion. Reduction of Na(+)/K(+)-pump activity by removal of extracellular potassium ([K(+)](o)) also uncoupled cells, but only after inhibition of K(ATP) channels. Inhibition of the Na(+)/Ca(2+)-exchange activity by SEA0400 or by a reduction of the equilibrium potential (making it more negative) also uncoupled the cells. Depletion of intracellular Na(+) and clamping of [Ca(2+)](i) at low concentrations prevented the uncoupling. The experiments suggest that the Na(+)/K(+)-pump may affect gap junction conductivity via localized changes in [Ca(2+)](i) through modulation of Na(+)/Ca(2+)-exchanger activity.

  5. Na5NbO5 and Na5TaO5 phases

    International Nuclear Information System (INIS)

    Darriet, J.; Maazaz, A.; Bouloux, J.C.; Delmas, C.

    1982-01-01

    New ternary oxides of formulas Na 5 NbO 5 and Na 5 TaO 5 have been prepared. They crystallize in the monoclinic system (space group C2/c). The crystal structure of Na 5 NbO 5 has been determined. It derives from a NaCl-type structure by ordering of the cations and of the oxygen vacancies in the anionic sublattice, the corresponding formula being Nasub(5/6)Nbsub(1/6)Osub(5/6)vacant sub(1/6). Sodium and niobium have a distorted square-pyramidal surrounding. (author)

  6. Suppression of Na interstitials in Na-F codoped ZnO

    Science.gov (United States)

    Huo, Wenxing; Mei, Zengxia; Tang, Aihua; Liang, Huili; Du, Xiaolong

    2018-04-01

    Controlling the formation of interstitial Na (Nai) self-compensating defects has been a long-term physics problem for effective Na doping in ZnO. Herein, we present an experimental approach to the suppression of Nai defects in ZnO via Na and F codoping under an oxygen-rich condition during the molecular beam epitaxy growth process. It is found that the incorporation of such large numbers of Na and F dopants (˜1020 cm-3) does not cause an obvious influence on the lattice parameters. Hall-effect measurements demonstrate that F doping efficiently raises the Fermi level (EF) of ZnO films, which is expected to make the formation energy of Nai and NaZn increase and decrease, respectively. Most of the Na atoms occupy the substitutional Zn sites, and the formation of Nai is suppressed consequently. Secondary ion mass spectrometry measurements reveal that F and Na atoms are tightly bonded together due to their strong Coulomb interaction. The enhanced deep level emission (DLE) in ZnO:Na-F is ascribed to the considerable amount of isolated Zn vacancy (VZn) defects induced by the elevated EF and the formation of neutral (" separators="| FO + - Na Zn - ) 0 complexes. On the other hand, formation of (" separators="| FO + - VZn 2 - ) - complexes in ZnO:F exhausts most of the isolated Zn vacancies, leading to the disappearance of the DLE band.

  7. MOŽNOSTI VSTOPA NA TUJE TRGE NA PRIMERU PODJETJA AWOODTURE

    OpenAIRE

    Orličnik, Urša

    2014-01-01

    Danes pojavljanje podjetja samo na domačem trgu ni več dovolj. Spremembe okolja, naraščanje konkurence ter hiter tehnološki napredek, silijo podjetja k nenehnemu prilagajanju in iskanju novih priložnosti tako na domačem kot tudi na tujem trgu. Internacionalizacija podjetja tako postaja vedno bolj pomemembna za preživetje podjetja. Internacionalizacija se v najširšem smislu nanaša na vse oblike mednarodnega ekonomskega sodelovanja. Je dinamičen proces, kateremu nujno sledi sprememba stanja...

  8. Elastic Coulomb breakup of 34Na

    Science.gov (United States)

    Singh, G.; Shubhchintak, Chatterjee, R.

    2016-08-01

    Background: 34Na is conjectured to play an important role in the production of seed nuclei in the alternate r -process paths involving light neutron rich nuclei very near the β -stability line, and as such, it is important to know its ground state properties and structure to calculate rates of the reactions it might be involved in, in the stellar plasma. Found in the region of `island of inversion', its ground state might not be in agreement with normal shell model predictions. Purpose: The aim of this paper is to study the elastic Coulomb breakup of 34Na on 208Pb to give us a core of 33Na with a neutron and in the process we try and investigate the one neutron separation energy and the ground state configuration of 34Na. Method: A fully quantum mechanical Coulomb breakup theory within the architecture of post-form finite range distorted wave Born approximation extended to include the effects of deformation is used to research the elastic Coulomb breakup of 34Na on 208Pb at 100 MeV/u. The triple differential cross section calculated for the breakup is integrated over the desired components to find the total cross-section, momentum, and angular distributions as well as the average momenta, along with the energy-angular distributions. Results: The total one neutron removal cross section is calculated to test the possible ground state configurations of 34Na. The average momentum results along with energy-angular calculations indicate 34Na to have a halo structure. The parallel momentum distributions with narrow full widths at half-maxima signify the same. Conclusion: We have attempted to analyze the possible ground state configurations of 34Na and in congruity with the patterns in the `island of inversion' conclude that even without deformation, 34Na should be a neutron halo with a predominant contribution to its ground state most probably coming from 33Na(3 /2+)⊗ 2 p3 /2ν configuration. We also surmise that it would certainly be useful and rewarding to test our

  9. Clues to NaCN formation

    Science.gov (United States)

    Quintana-Lacaci, G.; Cernicharo, J.; Velilla Prieto, L.; Agúndez, M.; Castro-Carrizo, A.; Fonfría, J. P.; Massalkhi, S.; Pardo, J. R.

    2017-11-01

    Context. ALMA is providing us essential information on where certain molecules form. Observing where these molecules emission arises from, the physical conditions of the gas, and how this relates with the presence of other species allows us to understand the formation of many species, and to significantly improve our knowledge of the chemistry that occurs in the space. Aims: We studied the molecular distribution of NaCN around IRC +10216, a molecule detected previously, but whose origin is not clear. High angular resolution maps allow us to model the abundance distribution of this molecule and check suggested formation paths. Methods: We modeled the emission of NaCN assuming local thermal equilibrium (LTE) conditions. These profiles were fitted to azimuthal averaged intensity profiles to obtain an abundance distribution of NaCN. Results: We found that the presence of NaCN seems compatible with the presence of CN, probably as a result of the photodissociation of HCN, in the inner layers of the ejecta of IRC +10216. However, similar as for CH3CN, current photochemical models fail to reproduce this CN reservoir. We also found that the abundance peak of NaCN appears at a radius of 3 × 1015 cm, approximately where the abundance of NaCl, suggested to be the parent species, starts to decay. However, the abundance ratio shows that the NaCl abundance is lower than that obtained for NaCN. We expect that the LTE assumption might result in NaCN abundances higher than the real ones. Updated photochemical models, collisional rates, and reaction rates are essential to determine the possible paths of the NaCN formation. Based on observations carried out with ALMA and the IRAM 30 m Telescope. ALMA is a partnership of ESO (representing its member states), NSF (USA) and NINS (Japan), together with NRC (Canada) and NSC and ASIAA (Taiwan), in cooperation with the Republic of Chile. The Joint ALMA Observatory is operated by ESO, AUI/NRAO and NAOJ. IRAM is supported by INSU/CNRS (France

  10. HCO3(-)-coupled Na+ influx is a major determinant of Na+ turnover and Na+/K+ pump activity in rat hepatocytes

    International Nuclear Information System (INIS)

    Fitz, J.G.; Lidofsky, S.D.; Weisiger, R.A.; Xie, M.H.; Cochran, M.; Grotmol, T.; Scharschmidt, B.F.

    1991-01-01

    Recent studies in hepatocytes indicate that Na(+)-coupled HCO3- transport contributes importantly to regulation of intracellular pH and membrane HCO3- transport. However, the direction of net coupled Na+ and HCO3- movement and the effect of HCO3- on Na+ turnover and Na+/K+ pump activity are not known. In these studies, the effect of HCO3- on Na+ influx and turnover were measured in primary rat hepatocyte cultures with 22Na+, and [Na+]i was measured in single hepatocytes using the Na(+)-sensitive fluorochrome SBFI. Na+/K+ pump activity was measured in intact perfused rat liver and hepatocyte monolayers as Na(+)-dependent or ouabain-suppressible 86Rb uptake, and was measured in single hepatocytes as the effect of transient pump inhibition by removal of extracellular K+ on membrane potential difference (PD) and [Na+]i. In hepatocyte monolayers, HCO3- increased 22Na+ entry and turnover rates by 50-65%, without measurably altering 22Na+ pool size or cell volume, and HCO3- also increased Na+/K+ pump activity by 70%. In single cells, exposure to HCO3- produced an abrupt and sustained rise in [Na+]i from approximately 8 to 12 mM. Na+/K+ pump activity assessed in single cells by PD excursions during transient K+ removal increased congruent to 2.5-fold in the presence of HCO3-, and the rise in [Na+]i produced by inhibition of the Na+/K+ pump was similarly increased congruent to 2.5-fold in the presence of HCO3-. In intact perfused rat liver, HCO3- increased both Na+/K+ pump activity and O2 consumption. These findings indicate that, in hepatocytes, net coupled Na+ and HCO3- movement is inward and represents a major determinant of Na+ influx and Na+/K+ pump activity. About half of hepatic Na+/K+ pump activity appears dedicated to recycling Na+ entering in conjunction with HCO3- to maintain [Na+]i within the physiologic range

  11. Coulomb excitation of radioactive 20, 21Na

    Science.gov (United States)

    Schumaker, M. A.; Cline, D.; Hackman, G.; Pearson, C.; Svensson, C. E.; Wu, C. Y.; Andreyev, A.; Austin, R. A. E.; Ball, G. C.; Bandyopadhyay, D.; Becker, J. A.; Boston, A. J.; Boston, H. C.; Buchmann, L.; Churchman, R.; Cifarelli, F.; Cooper, R. J.; Cross, D. S.; Dashdorj, D.; Demand, G. A.; Dimmock, M. R.; Drake, T. E.; Finlay, P.; Gallant, A. T.; Garrett, P. E.; Green, K. L.; Grint, A. N.; Grinyer, G. F.; Harkness, L. J.; Hayes, A. B.; Kanungo, R.; Lisetskiy, A. F.; Leach, K. G.; Lee, G.; Maharaj, R.; Martin, J.-P.; Moisan, F.; Morton, A. C.; Mythili, S.; Nelson, L.; Newman, O.; Nolan, P. J.; Orce, J. N.; Padilla-Rodal, E.; Phillips, A. A.; Porter-Peden, M.; Ressler, J. J.; Roy, R.; Ruiz, C.; Sarazin, F.; Scraggs, D. P.; Waddington, J. C.; Wan, J. M.; Whitbeck, A.; Williams, S. J.; Wong, J.

    2009-12-01

    The low-energy structures of the radioactive nuclei 20, 21Na have been examined using Coulomb excitation at the TRIUMF-ISAC radioactive ion beam facility. Beams of ˜ 5×106 ions/s were accelerated to 1.7MeV/A and Coulomb excited in a 0.5mg/cm^2 natTi target. Two TIGRESS HPGe clover detectors perpendicular to the beam axis were used for γ -ray detection, while scattered nuclei were observed by the Si detector BAMBINO. For 21Na , Coulomb excitation from the 3/2+ ground state to the first excited 5/2+ state was observed, while for 20Na , Coulomb excitation was observed from the 2+ ground state to the first excited 3+ and 4+ states. For both beams, B ( λ L) values were determined using the 2+ rightarrow 0+ de-excitation in 48Ti as a reference. The resulting B( E2) ↓ value for 21Na is 137±9 e^2fm^4, while the resulting B( λ L) ↓ values for 20Na are 55±6 e^2fm^4 for the 3+ rightarrow 2+ , 35.7±5.7 e^2 fm^4 for the 4+ rightarrow 2+ , and 0.154±0.030 μ_ N^2 for the 4+ rightarrow 3+ transitions. This analysis significantly improves the measurement of the 21Na B( E2) value, and provides the first experimental determination of B( λ L) values for the proton dripline nucleus 20Na .-1

  12. The plant vacuolar Na+/H+ antiport.

    Science.gov (United States)

    Barkla, B J; Apse, M P; Manolson, M F; Blumwald, E

    1994-01-01

    Salt stress imposes severe limitations on plant growth, however, the extent of growth reduction depends upon the soil salinity level and the plant species. One of the mechanisms employed by salt tolerant plants is the effective vacuolar compartmentalization of sodium. The sequestration of sodium into the vacuole occurs by the operation of a Na+/H+ antiport located at the tonoplast. Evidence for a plant vacuolar Na+/H+ antiport has been demonstrated in tissues, intact vacuoles and isolated tonoplast vesicles. In sugar beet cell suspensions, the activity of the vacuolar Na+/H+ antiport increased with increasing NaCl concentrations in the growth medium. This increased activity was correlated with the increased synthesis of a 170 kDa tonoplast polypeptide. In vivo labelling of tonoplast proteins showed the enhanced synthesis of the 170 kDa polypeptide not only upon exposure of the cells to salt, but also when the cells were grown in the presence of amiloride. Exposure of the cells to amiloride also resulted in increased vacuolar Na+/H+ antiport activity. Polyclonal antibodies raised against the 170 kDa polypeptide almost completely inhibited the antiport activity, suggesting the association of this protein with the plant vacuolar Na+/H+ antiport. Antibodies against the Na+/H+ antiport-associated polypeptide were used to screen a Beta lambda ZAP expression library. A partial clone of 1.65 kb was sequenced and found to encode a polypeptide with a putative transmembrane domain and a large hydrophilic C terminus. This clone showed no homology to any previously cloned gene at either the nucleic acid or the amino acid level.

  13. Protective effect of a phenolic extract containing indoline amides from Portulaca oleracea against cognitive impairment in senescent mice induced by large dose of D-galactose /NaNO2.

    Science.gov (United States)

    Wang, Peipei; Sun, Hongxiang; Liu, Dianyu; Jiao, Zezhao; Yue, Su; He, Xiuquan; Xia, Wen; Ji, Jianbo; Xiang, Lan

    2017-05-05

    brain AChE activity. PAAs as the bioactive principles of P. oleracea attenuated oxidative stress, improved survival rate, and enhanced cognitive function in D-gal/NaNO 2 -induced senile mice, similar to piracetam. This phenolic extract provides a promising candidate for prevention of aging and aging-related cognitive dysfunction in clinic. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

  14. TweetNaCl : a crypto library in 100 tweets

    NARCIS (Netherlands)

    Bernstein, D.J.; van Gastel, B.; Janssen, W.; Lange, T.; Schwabe, P.; Smetsers, S.; Aranha, D.F.; Menezes, A.

    2015-01-01

    This paper introduces TweetNaCl, a compact reimplementation of the NaCl library, including all 25 of the NaCl functions used by applications. TweetNaCl is published on Twitter and fits into just 100 tweets; the tweets are available from anywhere, any time, in an unsuspicious way. Distribution via

  15. Kupokelewa Zaidi Kwa Simu Ya Mkononi Kuliko Kompyuta Na ...

    African Journals Online (AJOL)

    Mtandao wa tovuti ni nyenzo ya msingi katika maendeleo ya uwanja wa mawasiliano unaounganisha watu na jamii mbalimbali katika ulimwengu wa leo unaotandawaa. Katika “ulimwengu wa kwanza na wa pili”, yaani mabara ya Amerika, Uropa na Asia, maendeleo na mapinduzi makubwa katika uwanja wa teknolojia ya ...

  16. Mabadiliko Ya Kifonolojia Na Kimofolojia Wakati Wa Utohozi Wa ...

    African Journals Online (AJOL)

    Mwingiliano wa lugha ya Kiswahili na Kiarabu una historia ndefu kidogo. Inasemekana Waarabu walianza muwasala na 'Waswahili' tangu karne ya kwanza (BK) (Polome 1967:9). Kutokana na muwasala huo wa muda mrefu, lugha hizi mbili (Kiarabu na Kiswahili) zimeathiriana sana. Lakini kuna maoni kwamba Kiarabu ...

  17. O Passeio Público do Rio de Janeiro na Literatura, na Pintura e na Fotografia do Século XIX

    Directory of Open Access Journals (Sweden)

    Solange de Aragão

    2012-06-01

    Full Text Available Este artigo tem como objetivo geral e mais amplo chamar a atenção dos pesquisadores para a importância da literatura, da pintura e da fotografia como fontes documentais para a construção da História do Paisagismo no Brasil por meio de um estudo de caso muito particular: o Passeio Público do Rio de Janeiro no século XIX. São objetivos específicos apresentar e analisar o modo como esse espaço livre público aparece na literatura, na pintura e na fotografia desse período, considerando suas transformações paisagísticas.

  18. VPLIV CENE NA ZADOVOLJSTVO IN ZVESTOBO UPORABNIKOV TELEKOMUNIKACIJSKIH STORITEV

    OpenAIRE

    Majcen, Mateja

    2016-01-01

    Cena izdelka ali storitve, ki jo plača uporabnik, ima pomemben vpliv na zadovoljstvo ali nezadovoljstvo uporabnika z uporabo tega izdelka ali storitve in posledično na zadovoljstvo do podjetja. Glede na to, da se različni avtorji strinjajo in to tudi dokazujejo z raziskavami, zadovoljstvo nedvoumno vpliva na zvestobo uporabnika, zvestoba pa na dolgoročno uspešnost podjetja, smo v delu ugotavljali, kako sama cena storitve vpliva na zadovoljstvo in kako posredno preko zadovoljstva vpliva na zve...

  19. Molecular dynamics investigation of Na+ in Na2Ni2TeO6

    International Nuclear Information System (INIS)

    Sau, Kartik; Kumar, P. Padma

    2014-01-01

    An inter-atomic potential for Na 2 Ni 2 TeO 6 in the Parrinello- Rahman-Vashishta (PRV) model is parameterized empirically. The potential reproduces variety of structural and transport properties of that material in good agreement with recent experimental results. The study provides fresh insights on the migration channels and mechanism of Na + in the system

  20. Muziki wa Hip Hop na Haki Za Kijamii: Dhima, Changamoto na ...

    African Journals Online (AJOL)

    Ni dhahiri kuwa haki za kijamii zinaweza kuwasilishwa kwa jamii pana kupitia sanaa ya hip hop. Makala haya basi, yanabainisha dhima na mchango wa muziki wa hip hop katika masuala ya haki za kijamii, yanafafanua changamoto za muziki huu katika kuwasilisha haki za kijamii na kutoa mapendekezo kwa makundi ...

  1. NaI(Tl) electron energy resolution

    CERN Document Server

    Mengesha, W

    2002-01-01

    NaI(Tl) electron energy resolution eta sub e was measured using the Modified Compton Coincidence Technique (MCCT). The MCCT allowed detection of nearly monoenergetic internal electrons resulting from the scattering of incident 662 keV gamma rays within a primary NaI(Tl) detector. Scattered gamma rays were detected using a secondary HPGe detector in a coincidence mode. Measurements were carried out for electron energies ranging from 16 to 438 keV, by varying the scattering angle. Measured HPGe coincidence spectra were deconvolved to determine the scattered energy spectra from the NaI(Tl) detector. Subsequently, the NaI(Tl) electron energy spectra were determined by subtracting the energy of scattered spectra from the incident source energy (662 keV). Using chi-squared minimization, iterative deconvolution of the internal electron energy spectra from the measured NaI(Tl) spectra was then used to determine eta sub e at the electron energy of interest. eta sub e values determined using this technique represent va...

  2. Anion-coupled Na efflux mediated by the human red blood cell Na/K pump

    International Nuclear Information System (INIS)

    Dissing, S.; Hoffman, J.F.

    1990-01-01

    The red cell Na/K pump is known to continue to extrude Na when both Na and K are removed from the external medium. Because this ouabain-sensitive flux occurs in the absence of an exchangeable cation, it is referred to as uncoupled Na efflux. This flux is also known to be inhibited by 5 mM Nao but to a lesser extent than that inhibitable by ouabain. Uncoupled Na efflux via the Na/K pump therefore can be divided into a Nao-sensitive and Nao-insensitive component. We used DIDS-treated, SO4-equilibrated human red blood cells suspended in HEPES-buffered (pHo 7.4) MgSO4 or (Tris)2SO4, in which we measured 22Na efflux, 35SO4 efflux, and changes in the membrane potential with the fluorescent dye, diS-C3 (5). A principal finding is that uncoupled Na efflux occurs electroneurally, in contrast to the pump's normal electrogenic operation when exchanging Nai for Ko. This electroneutral uncoupled efflux of Na was found to be balanced by an efflux of cellular anions. (We were unable to detect any ouabain-sensitive uptake of protons, measured in an unbuffered medium at pH 7.4 with a Radiometer pH-STAT.) The Nao-sensitive efflux of Nai was found to be 1.95 +/- 0.10 times the Nao-sensitive efflux of (SO4)i, indicating that the stoichiometry of this cotransport is two Na+ per SO4=, accounting for 60-80% of the electroneutral Na efflux. The remainder portion, that is, the ouabain-sensitive Nao-insensitive component, has been identified as PO4-coupled Na transport and is the subject of a separate paper. That uncoupled Na efflux occurs as a cotransport with anions is supported by the result, obtained with resealed ghosts, that when internal and external SO4 was substituted by the impermeant anion, tartrate i,o, the efflux of Na was inhibited 60-80%. This inhibition could be relieved by the inclusion, before DIDS treatment, of 5 mM Cli,o

  3. Na/K pump inactivation, subsarcolemmal Na measurements, and cytoplasmic ion turnover kinetics contradict restricted Na spaces in murine cardiac myocytes.

    Science.gov (United States)

    Lu, Fang-Min; Hilgemann, Donald W

    2017-07-03

    Decades ago, it was proposed that Na transport in cardiac myocytes is modulated by large changes in cytoplasmic Na concentration within restricted subsarcolemmal spaces. Here, we probe this hypothesis for Na/K pumps by generating constitutive transsarcolemmal Na flux with the Na channel opener veratridine in whole-cell patch-clamp recordings. Using 25 mM Na in the patch pipette, pump currents decay strongly during continuous activation by extracellular K (τ, ∼2 s). In contradiction to depletion hypotheses, the decay becomes stronger when pump currents are decreased by hyperpolarization. Na channel currents are nearly unchanged by pump activity in these conditions, and conversely, continuous Na currents up to 0.5 nA in magnitude have negligible effects on pump currents. These outcomes are even more pronounced using 50 mM Li as a cytoplasmic Na congener. Thus, the Na/K pump current decay reflects mostly an inactivation mechanism that immobilizes Na/K pump charge movements, not cytoplasmic Na depletion. When channel currents are increased beyond 1 nA, models with unrestricted subsarcolemmal diffusion accurately predict current decay (τ ∼15 s) and reversal potential shifts observed for Na, Li, and K currents through Na channels opened by veratridine, as well as for Na, K, Cs, Li, and Cl currents recorded in nystatin-permeabilized myocytes. Ion concentrations in the pipette tip (i.e., access conductance) track without appreciable delay the current changes caused by sarcolemmal ion flux. Importantly, cytoplasmic mixing volumes, calculated from current decay kinetics, increase and decrease as expected with osmolarity changes (τ >30 s). Na/K pump current run-down over 20 min reflects a failure of pumps to recover from inactivation. Simulations reveal that pump inactivation coupled with Na-activated recovery enhances the rapidity and effectivity of Na homeostasis in cardiac myocytes. In conclusion, an autoregulatory mechanism enhances cardiac Na/K pump activity when

  4. Muscle K+, Na+, and Cl- disturbances and Na+-K+ pump inactivation: implications for fatigue

    DEFF Research Database (Denmark)

    McKenna, Michael J; Bangsbo, Jens; Renaud, Jean-Marc

    2008-01-01

    (+)-ATPase activity during exercise stabilizes Na(+) and K(+) concentration gradients and membrane excitability and thus protects against fatigue. However, during intense contraction some Na(+)-K(+) pumps are inactivated and together with further ionic disturbances, likely precipitate muscle fatigue.......Membrane excitability is a critical regulatory step in skeletal muscle contraction and is modulated by local ionic concentrations, conductances, ion transporter activities, temperature, and humoral factors. Intense fatiguing contractions induce cellular K(+) efflux and Na(+) and Cl(-) influx......, causing pronounced perturbations in extracellular (interstitial) and intracellular K(+) and Na(+) concentrations. Muscle interstitial K(+) concentration may increase 1- to 2-fold to 11-13 mM and intracellular K(+) concentration fall by 1.3- to 1.7-fold; interstitial Na(+) concentration may decline by 10 m...

  5. Metallic Na formation in NaCl crystals with irradiation of electron or vacuum ultraviolet photon

    Energy Technology Data Exchange (ETDEWEB)

    Owaki, Shigehiro [Osaka Prefecture Univ., Sakai, Osaka (Japan). Coll. of Integrated Arts and Sciences; Koyama, Shigeko; Takahashi, Masao; Kamada, Masao; Suzuki, Ryouichi

    1997-03-01

    Metallic Na was formed in NaCl single crystals with irradiation of a variety of radiation sources and analyzed the physical states with several methods. In the case of irradiation of 21 MeV electron pulses to the crystal blocks, the optical absorption and lifetime measurement of positron annihilation indicated appearance of Na clusters inside. Radiation effects of electron beam of 30 keV to the crystals in vacuum showed the appearance of not only metallic Na but atomic one during irradiation with Auger electron spectroscopy. Intense photon fluxes in vacuum ultraviolet region of synchrotron radiation were used as another source and an analyzing method of ultraviolet photoelectron spectroscopy. The results showed the metallic Na layered so thick that bulk plasmon can exist. (author)

  6. Hydrolysis of Rice Straw Pretreated by Na2SO3 Over Fe-resin/NaCl

    Directory of Open Access Journals (Sweden)

    YANG Hui

    2017-05-01

    Full Text Available To increase the conversion of rice straw(RS and the yield of products, we employed three methods, which were ultrasonic wave, steam explosion and Na2SO3 pretreatment to pretreat RS(the treated RS noted as CS-RS, ZQ-RS and Na2SO3-RS, respectively and found that Na2SO3 treatment was the best pretreatment method based on XRD, SEM, elemental analysis and content of cellulose, hemicellulose and lignin. The conversion of Na2SO3-RS and the yield of total reducing sugar(TRS and levulinic acid(LA were 97.3%, 29.6% and 13.5%, respectively by 10% Fe-resin in 3.3% NaCl solution under 200 ℃.

  7. Na-ion dynamics in Quasi-1D compound NaV2O4

    International Nuclear Information System (INIS)

    Månsson, M; Umegaki, I; Nozaki, H; Higuchi, Y; Sugiyama, J; Kawasaki, I; Watanabe, I; Sakurai, H

    2014-01-01

    We have used the pulsed muon source at ISIS to study high-temperature Na-ion dynamics in the quasi-one-dimensional (Q1D) metallic antiferromagnet NaV 2 O 4 . By performing systematic zero-field and longitudinal-field measurements as a function of temperature we clearly distinguish that the hopping rate increases exponentially above T diff ≈ 250 K. The data is well fitted to an Arrhenius type equation typical for a diffusion process, showing that the Na-ions starts to be mobile above T diff . Such results make this compound very interesting for the tuning of Q1D magnetism using atomic-scale ion-texturing through the periodic potential from ordered Na-vacancies. Further, it also opens the door to possible use of NaV 2 O 4 and related compounds in energy related applications

  8. Summer sudden Na number density enhancements measured with the ALOMAR Weber Na Lidar

    Directory of Open Access Journals (Sweden)

    D. Heinrich

    2008-05-01

    Full Text Available We present summer Na-densities and atmospheric temperatures measured 80 to 110 km above the Arctic Lidar Observatory for Middle Atmosphere Research (ALOMAR. The Weber Na Lidar is part of ALOMAR, located at 69° N in Norway, 150 km north of the Arctic Circle. The sun does not set here during the summer months, and measurements require a narrowband Faraday Anomalous Dispersion Optical Filter (FADOF.

    We discuss an observed sudden enhancement in the Na number density around 22:00 UT on 1 to 2 June 2006. We compare this observation with previous summer measurements and find a frequent appearance of Na number density enhancements near local midnight. We describe the time of appearance, the altitude distribution, the duration and the strength of these enhancements and compare them to winter observations. We investigate possible formation mechanisms and, as others before, we find a strong link between these Na number density enhancements and sporadic E layers.

  9. Summer sudden Na number density enhancements measured with the ALOMAR Weber Na Lidar

    Directory of Open Access Journals (Sweden)

    D. Heinrich

    2008-05-01

    Full Text Available We present summer Na-densities and atmospheric temperatures measured 80 to 110 km above the Arctic Lidar Observatory for Middle Atmosphere Research (ALOMAR. The Weber Na Lidar is part of ALOMAR, located at 69° N in Norway, 150 km north of the Arctic Circle. The sun does not set here during the summer months, and measurements require a narrowband Faraday Anomalous Dispersion Optical Filter (FADOF. We discuss an observed sudden enhancement in the Na number density around 22:00 UT on 1 to 2 June 2006. We compare this observation with previous summer measurements and find a frequent appearance of Na number density enhancements near local midnight. We describe the time of appearance, the altitude distribution, the duration and the strength of these enhancements and compare them to winter observations. We investigate possible formation mechanisms and, as others before, we find a strong link between these Na number density enhancements and sporadic E layers.

  10. Structure-function relationships of Na+, K+, ATP, or Mg2+ binding and energy transduction in Na,K-ATPase

    DEFF Research Database (Denmark)

    Jorgensen, Peter L.; Pedersen, Per Amstrup

    2000-01-01

    Na,K-ATPase; Mutagenesis; Na+ binding; K+ binding; Tl+ binding; Mg2+ binding; ATP binding; Cation binding site; Energy transduction......Na,K-ATPase; Mutagenesis; Na+ binding; K+ binding; Tl+ binding; Mg2+ binding; ATP binding; Cation binding site; Energy transduction...

  11. Na2SO4-based solid electrolytes for SOx sensors

    DEFF Research Database (Denmark)

    Rao, N.; Schoonman, J.; Toft Sørensen, O.

    1992-01-01

    on the phases present and the structure of the specimens. From a point of view of practical application as SOx sensor material, the Na2SO4 + 5 mol% Y2(SO4)3 + Na2WO4 and Na2SO4+ 4 mol% La2(SO4)3 + Na2WO4 materials are better than undoped Na2SO4 because of their higher conductivity, and absence of a phase...

  12. Long-Range Effects of Na(+) Binding in Na,K-ATPase Reported by ATP.

    Science.gov (United States)

    Middleton, David A; Fedosova, Natalya U; Esmann, Mikael

    2015-12-01

    This paper addresses the question of long-range interactions between the intramembranous cation binding sites and the cytoplasmic nucleotide binding site of the ubiquitous ion-transporting Na,K-ATPase using (13)C cross-polarization magic-angle spinning (CP-MAS) solid-state nuclear magnetic resonance. High-affinity ATP binding is induced by the presence of Na(+) as well as of Na-like substances such as Tris(+), and these ions are equally efficient promoters of nucleotide binding. CP-MAS analysis of bound ATP with Na,K-ATPase purified from pig kidney membranes reveals subtle differences in the nucleotide interactions within the nucleotide site depending on whether Na(+) or Tris(+) is used to induce binding. Differences in chemical shifts for ATP atoms C1' and C5' observed in the presence of Na(+) or Tris(+) suggest alterations in the residues surrounding the bound nucleotide, hydrogen bonding, and/or conformation of the ribose ring. This is taken as evidence of a long-distance communication between the Na(+)-filled ion sites in the membrane interior and the nucleotide binding site in the cytoplasmic domain and reflects the first conformational change ultimately leading to phosphorylation of the enzyme. Stopped-flow fluorescence measurements with the nucleotide analogue eosin show that the dissociation rate constant for eosin is larger in Tris(+) than in Na(+), giving kinetic evidence of the difference in structural effects of Na(+) and Tris(+). According to the recent crystal structure of the E1·AlF4(-)·ADP·3Na(+) form, the coupling between the ion binding sites and the nucleotide side is mediated by, among others, the M5 helix.

  13. Tecnologia simplificada na enfermagem materno infantil

    Directory of Open Access Journals (Sweden)

    Selma Campestrini

    1991-09-01

    Full Text Available A autora apresenta três modelos de tecnologia simplificada da enfermagem materno infantil: o equipamento didático SEIO COBAIA para treinar exercícios e massagens da mama e mamilo; a peça indumentária SUPRETRAUMA - sutiã preventivo de traumatismo mamilar - usado por gestantes; e, a técnica para reverter mamilo umbilicado durante o puerperio imediato. Além de corroborar na promoção do aleitamento materno e na prevenção de desmame precoce, demonstra a possibilidade da enfermagem relacionar o saber teórico-científico com o saber tecnico-prático, na saúde da mulher e da criança, com tecnologia adequada às necessidades, à compreensão e ao bem estar da população.

  14. Eletrencefalograma na síndrome parkinsoniana

    Directory of Open Access Journals (Sweden)

    José Geraldo Camargo Lima

    1973-09-01

    Full Text Available Foram estudados os eletrencefalogramas de 50 pacientes parkinsonianos livres de qualquer antecedente convulsivo, sendo registrados traçados anormais em 40% dos casos. A incidência de traçados anormais foi maior na síndrome parkinsoniana bilateral do que na unilateral (52% e 25%, respectivamente. Entre as anormalidades assinaladas foram as paroxísticas as mais freqüentes (65% dos casos, caracterizando-se predominantemente por surtos de ondas teta. O registro de anormalidades paroxísticas do tipo irritativo encontrado em três casos é salientado. Alterações da atividade de base foram assinaladas em 35% dos pacientes. A idade dos pacientes não parece ter tido importante papel na gênese das anormalidades eletrencefalográficas.

  15. GLOBAL COMMODITY CHAINS NA PERSPECTIVA DE MARKETING

    Directory of Open Access Journals (Sweden)

    Flávio Régio Brambilla

    2014-01-01

    Full Text Available O presente estudo visa a estabelecer uma relação entre as estratégias de canais globais com aspectos do marketing, como a força da marca. Trata-se de conciliar atributos de Estratégia e Marketing. As mudanças econômicas globais levaram a transformações na competição das empresas, obrigando-as a ingressar numa discussão aprimorada acerca das estratégias e competências. Com base na ideia da detenção do conhecimento e das habilidades como verdadeiros diferenciais competitivos, muitos players passam a atuar na gestão do design e da marca como elementos centrais das políticas de negócios, onde a proposição de valor pode ser mais bem definida aos mercados consumidores.

  16. Recent results from NA61/SHINE

    CERN Document Server

    Puławski, Szymon

    2015-01-01

    The main physics goals of the NA61/SHINE programme on strong interactions are the study of the properties of the onset of deconfinement and the search for signatures of the critical point of strongly interacting matter. These goals are pursued by performing an energy (beam momentum 13A -158A GeV/c) and system size (p+p, p+Pb, Be+Be, Ar+Sc, Xe+La) scan. This publication reviews results and plans of NA61/SHINE. In particular, recent inclusive spectra and new results on fluctuations and correlations of identified hadrons in inelastic p+p and centrality selected Be+Be interactions at the SPS energies are presented. The energy dependence of quantities inspired by the Statistical Model of the Early Stage (kink, horn and step) show unexpected behavior in p+p collisions. The NA61/SHINE results are compared with the corresponding data of other experiments and model predictions.

  17. Recent results from NA61/SHINE

    CERN Document Server

    Kowalski, Seweryn

    2015-01-01

    The aim of the NA61/SHINE ion programme is to explore the QCD phase diagram within the range of thermodynamical variables accessible by the SPS. Moreover the experiment provides precision hadron production measurements to improve computation of neutrino fluxes in neutrino oscillation experiments and for improving air shower simulations of cosmic-ray experiments. The main physics goals of the NA61/SHINE ion programme are the study of the properties of the onset of deconfinement and the search for signatures of the critical point of strongly interacting matter. These goals are pursued by performing an energy (beam momentum 13A – 158 A GeV/c) and system size (p+p, p+Pb, Be+Be, Ar+Sc, Xe+La) scan. This paper reviews the status and results of the NA61/SHINE experiment.

  18. A Study of the Distribution of Sodium Cations in the Zeolites NaX, NaY and ZnNaY Using Carbon Monoxide Adsorption and 23Na NMR Techniques

    Science.gov (United States)

    Seidel, A.; Boddenberg, B.

    1995-03-01

    The zeolites NaX, NaY, Zn(55)NaY, and Zn(74)NaY were investigated by means of carbon monoxide adsorption and with static and magic angle spinning (MAS) 23Na NMR spectroscopy. The Na+ distribution between the sodalite (ß)- and supercages of the fully hydrated zeolites NaX and NaY were found to agree with XRD results. In the hydrated zinc-exchanged zeolites the Na+ ions almost exclusively populate the ß-cages. The adsorption isotherms of CO in the dehydrated zeolites were analyzed quantitatively to yield the concentrations of Na+ residing in the supercages. The measured static and MAS 23Na NMR spectra were analyzed by comparing their widths and shapes with simulated central transition patterns and yield, inter alia, the concentrations of Na+ associated with the spectrum components. Arguments are put forward that 23Na NMR of dehydrated zeolites is well suited to distinguish Na+ cations in highly symmetric environments and mobile Na+ species from others located on general positions, but further resolution is hardly feasible.

  19. Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state.

    Science.gov (United States)

    Kanai, Ryuta; Ogawa, Haruo; Vilsen, Bente; Cornelius, Flemming; Toyoshima, Chikashi

    2013-10-10

    Na(+),K(+)-ATPase pumps three Na(+) ions out of cells in exchange for two K(+) taken up from the extracellular medium per ATP molecule hydrolysed, thereby establishing Na(+) and K(+) gradients across the membrane in all animal cells. These ion gradients are used in many fundamental processes, notably excitation of nerve cells. Here we describe 2.8 Å-resolution crystal structures of this ATPase from pig kidney with bound Na(+), ADP and aluminium fluoride, a stable phosphate analogue, with and without oligomycin that promotes Na(+) occlusion. These crystal structures represent a transition state preceding the phosphorylated intermediate (E1P) in which three Na(+) ions are occluded. Details of the Na(+)-binding sites show how this ATPase functions as a Na(+)-specific pump, rejecting K(+) and Ca(2+), even though its affinity for Na(+) is low (millimolar dissociation constant). A mechanism for sequential, cooperative Na(+) binding can now be formulated in atomic detail.

  20. MANAGEMENT DOGODKOV NA PRIMERU NIKE KONVENCIJE

    OpenAIRE

    Kapić, Sara

    2010-01-01

    V diplomski nalogi je predstavljen potek ustvarjanja in izvedbe dogodka, ki zajema številne aktivnosti, in sicer na primeru Nike konvencije. Namen diplomske naloge je namreč podati kritično oceno izvajanja aktivnosti, z namenom ugotoviti, katere aktivnosti bi se v okviru upravljanja z dogodkom lahko izpeljale boljše in podati predloge za uspešnejšo zasnovo in organizacijo naslednje Nike konvencije. Na podlagi posnetka je ugotovljeno, da je pri organizaciji, vodenju, izvedbi in nadzoru prihaja...

  1. A Imagem como Ruína

    Directory of Open Access Journals (Sweden)

    Míriam Volpe

    2001-12-01

    Full Text Available O dialogismo ente o filme Citizen Kane, de Orson Welles, e o poema “Kubla Khan”, de S.T. Coleridgé, é analisado, sendo evidenciados não só o tema em comum – o mito do Paraíso perdido – como também a similariedade na organização do disurso na justaposição das images, como fragmentos da memória a serem preservados.

  2. Recent results and prospects from NA62

    Directory of Open Access Journals (Sweden)

    Bizzeti Andrea

    2016-01-01

    K+ → π+ vv̄ is a theoretically very clean decay where indirect effects of new physics may be detectable. The NA62 apparatus has been significantly upgraded between 2008 and 2014 in order to measure the branching ratio of this decay with 10% precision. The NA62 experiment took data with the new setup in pilot runs in 2014 and 2015, reaching the design beam intensity. Results of first data quality studies in view of the 2016-2017 physics runs are presented.

  3. Prenova razsvetljave na Fakulteti za elektrotehniko

    OpenAIRE

    ŠTAJDOHAR, JAN

    2015-01-01

    Pri energetskem pregledu stavbe Fakultete za elektrotehniko v Ljubljani je bilo ugotovljeno, da je razsvetljava prostorov na fakulteti v veliko primerih stara, neprimerna in energetsko potratna. V diplomski nalogi smo se posvetili energetski analizi prenove razsvetljave predavalnice P7 in kabineta AZ101. Pri načrtovanju in izbiri svetil smo upoštevali vse tehnične in energetske smernice za učinkovito razsvetljavo prostorov za izobraževanje. V uvodu smo opisali fizikalne osnove svetlobe, k...

  4. Osteossarcoma parosteal: aspectos na radiologia convencional

    OpenAIRE

    Nanci Neto,Francisco; Marchiori,Edson; Vianna,Alberto Domingues; Aymoré,Ierecê Lins; Almeida,Ana Luiza Brito de; Irion,Klaus L.; Collares,Felipe Birchal

    2007-01-01

    OBJETIVO: Avaliar os achados clínicos mais importantes do osteossarcoma parosteal e descrever os seus aspectos mais comuns na radiologia convencional. MATERIAIS E MÉTODOS: Estudo retrospectivo com 26 pacientes com osteossarcoma parosteal, provenientes do arquivo do Clube do Osso, Rio de Janeiro, RJ, e análise dos principais achados clínicos e aspectos radiológicos. RESULTADOS: A doença predominou em pacientes do sexo feminino e teve idade média de acometimento na terceira década de vida. Os a...

  5. Lamiaceae na Serra Negra, Minas Gerais, Brasil

    OpenAIRE

    Mota, Michelle Christine de Almeida; Pastore, José Floriano Barêa; Marques Neto, Roberto; Harley, Raymond Mervyn; Salimena, Fátima Regina

    2017-01-01

    Resumo A Serra Negra está inserida na área do Complexo da Serra da Mantiqueira, no domínio da Mata Atlântica, com altitudes entre 800 e 1.650 m, com vegetação em mosaico representada, entre outros, por campos rupestres em afloramentos quartzíticos e floresta nebulares. A família Lamiaceae (Labiatae) está representada na Serra Negra por 10 gêneros e 17 espécies: Aegiphila integrifolia, Cantinoa carpinifolia, C. macrotera, C. muricata, Eriope macrostachya, Hoehnea scutellarioides, Hyptidendron ...

  6. VARNOSTNA POLITIKA NA PODROČJU INFORMATIKE

    OpenAIRE

    Šavor, Gašper

    2011-01-01

    Informacijska tehnologija postaja vse bolj pomemben del poslovanja vsakega podjetja ter ţivljenja vsakega posameznika. Zato je v interesu vseh, da so ključne informacije dobro zaščitene. V prvem delu diplomske naloge smo predstavili informacijske sisteme, njihovo delitev ter vrste. Prav tako smo podrobneje predstavili ţivljenjski cikel ter 4-stopenjski model razvoja informacijskega sistema. V osrednjem delu naloge smo se osredotočili na nevarnosti na področju informatike ter vrste zašči...

  7. ARTE E TRANSGRESSÃO NA MODERNIDADE

    OpenAIRE

    Cascelli Farinasso, Gabriela

    2014-01-01

    O presente artigo busca explorar a arte como ferramenta para mudanças sociais na modernidade relacionando-a com os conceitos apresentados por Nicolas Bourriaud em seu livro Estética Relacional. A Street Art é apresentada como recorte dentre os movimentos artísticos, ressaltando-se sua importância e suas características do ponto de vista espacial e temporal e na criação de “lugares de pausa” no meio urbano, que levam o observador a refletir sobre a obra e o desviam do seu percurso. A transgres...

  8. O passado presente na literatura angolana

    Directory of Open Access Journals (Sweden)

    Rita Chaves

    2000-03-01

    Full Text Available A poderosa presença da História na configuração do projeto literário angolano assegura ao passado um lugar de destaque. Como matriz de significados no processo de construção da identidade cultural de uma sociedade em manifesto movimento, o passado ganha formas e sentidos múltiplos que interferem na leitura do presente e nas projeções do futuro realizadas pelos escritores angolanos, do período colonialaos nossos dias.

  9. Controlo de qualidade na empresa Valvie

    OpenAIRE

    Agrela, Sandra da Conceição Rodrigues

    2015-01-01

    Dissertação apresentada à Escola Superior Agrária do Instituto Politécnico de Castelo Branco para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Inovação e Qualidade na Produção Alimentar. A qualidade está presente na realidade das indústrias atualmente mais do que nunca. Partindo do princípio de que qualidade seja atender e superar a expetativa do consumidor, a empresa que apresentar melhor performance nesse quesito será a de maior sucesso no mercado...

  10. O sentimento de respeito na moral kantiana

    OpenAIRE

    Stadnick, Maria Margareth

    2007-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas. Programa de Pós-Graduação em Filosofia. A presente pesquisa tem como proposta fundamental a investigação do sentimento de respeito na moral kantiana. Neste sentido, nos detemos a investigar sua relação com a proposta moral de Kant, assim como verificarmos o lugar sistemático que ocupa o sentimento de respeito na moral kantiana. Dentro desse espírito, buscamos reconstruir a estrutura arg...

  11. Status for 2017, CERN NA63

    CERN Document Server

    Uggerhoej, UI

    2017-01-01

    In the NA63 experiment of May-June 2017 the purpose was to look for the effect of classical radiation reaction as described in \\cite{DiPiazza20171} but for 50 GeV positrons aligned to the (110) plane of silicon crystals of varying thicknesses in the range 1-6 mm. The data which was taken during the run shows promising results, but the final verdict awaits accurate calculations of the theoretically expected spectra, and a final analysis. For the 2016 results on quantum radiation reaction obtained by CERN NA63, we have submitted a manuscript, which is presently under refereeing \\cite{Wist17}.

  12. O problema do conhecimento verdadeiro na epidemiologia

    Directory of Open Access Journals (Sweden)

    Ayres José Ricardo de Carvalho Mesquita

    1992-01-01

    Full Text Available São examinadas as bases filosóficas da validação do conhecimento científico, com o intuito de estabelecer uma visão crítica a respeito da adoção das proposições de Popper na epidemiologia. Ressalta-se o caráter conservador que resulta das limitações técnicas implicadas na sua adoção, não obstante o evidente aumento da racionalidade e da criatividade heurística que propicia.

  13. Europlanet-2020 NA1 Exchange Program

    Science.gov (United States)

    Genzer, M.; Szego, K.; Haukka, H.; Harri, A.-M.

    2017-09-01

    The task of Exchange Program of NA1 is to support the activities of EPN2020 with experts and scientific exchange whenever it is needed. Short visits (up to 1 week) with the goal of improving infrastructure facilities and services offered to the scientific community are supported from this task. Since the start of the EPN2020 in September 2015 we have received and approved 14 applications for exchange program travel. More general and specifically targeted calls are planned for the future. The calls are announced on Europlanet-2020 NA1 web site.

  14. Abordagem neurologica na sindrome do X fragil

    OpenAIRE

    Marilisa Mantovani Guerreiro

    1993-01-01

    Resumo: Com o propósito de realizar a abordagem neurológica na Síndrome do X Frágil (SXF), estudaram-se 11 pacientes com este diagnóstico citogenético. A idade variou de 8 a 19 anos. Nove pacientes eram do sexo masculino e dois do feminino. Todos os indivíduos apresentaram pavilhões auriculares grandes e faces alongadas. Observou-se fronte proeminente em 63% dos casos e macrorquidia em 33% dentre aqueles do sexo masculino. Atraso na aquisição da fala, fala repetitiva, perseverativa, impulsiva...

  15. Na+/K+-ATPase: Activity and inhibition

    Science.gov (United States)

    Čolović, M.; Krstić, D.; Krinulović, K.; Momić, T.; Savić, J.; Vujačić, A.; Vasić, V.

    2009-09-01

    The aim of the study was to give an overview of the mechanism of inhibition of Na+/K+-ATPase activity induced by some specific and non specific inhibitors. For this purpose, the effects of some ouabain like compounds (digoxin, gitoxin), noble metals complexes ([PtCl2DMSO2], [AuCl4]-, [PdCl4]2-, [PdCl(dien)]+, [PdCl(Me4dien)]+), transition metal ions (Cu2+, Zn2+, Fe2+, Co2+), and heavy metal ions (Hg2+, Pb2+, Cd2+) on the activity of Na+/K+-ATPase from rat synaptic plasma membranes (SPM), porcine cerebral cortex and human erythrocytes were discussed.

  16. Na, K-ATPase as signaling transducer

    OpenAIRE

    Li, Juan

    2007-01-01

    It is now generally agreed that Na,K-ATPase (NKA), in addition to its role in the maintenance of Na+ and K+ gradients across the cell membrane, is a signal transducer. Our group has identified a novel signaling pathway where NKA interact with IP3R to form a signaling microdomain. Ouabain, a specific ligand of NKA, activates this pathway, triggers slow Ca2+ oscillations and activates NF-κB. In current study, the molecular mechanisms and some important downstream effects of NK...

  17. Glutathionylation-Dependence of Na(+)-K(+)-Pump Currents Can Mimic Reduced Subsarcolemmal Na(+) Diffusion.

    Science.gov (United States)

    Garcia, Alvaro; Liu, Chia-Chi; Cornelius, Flemming; Clarke, Ronald J; Rasmussen, Helge H

    2016-03-08

    The existence of a subsarcolemmal space with restricted diffusion for Na(+) in cardiac myocytes has been inferred from a transient peak electrogenic Na(+)-K(+) pump current beyond steady state on reexposure of myocytes to K(+) after a period of exposure to K(+)-free extracellular solution. The transient peak current is attributed to enhanced electrogenic pumping of Na(+) that accumulated in the diffusion-restricted space during pump inhibition in K(+)-free extracellular solution. However, there are no known physical barriers that account for such restricted Na(+) diffusion, and we examined if changes of activity of the Na(+)-K(+) pump itself cause the transient peak current. Reexposure to K(+) reproduced a transient current beyond steady state in voltage-clamped ventricular myocytes as reported by others. Persistence of it when the Na(+) concentration in patch pipette solutions perfusing the intracellular compartment was high and elimination of it with K(+)-free pipette solution could not be reconciled with restricted subsarcolemmal Na(+) diffusion. The pattern of the transient current early after pump activation was dependent on transmembrane Na(+)- and K(+) concentration gradients suggesting the currents were related to the conformational poise imposed on the pump. We examined if the currents might be accounted for by changes in glutathionylation of the β1 Na(+)-K(+) pump subunit, a reversible oxidative modification that inhibits the pump. Susceptibility of the β1 subunit to glutathionylation depends on the conformational poise of the Na(+)-K(+) pump, and glutathionylation with the pump stabilized in conformations equivalent to those expected to be imposed on voltage-clamped myocytes supported this hypothesis. So did elimination of the transient K(+)-induced peak Na(+)-K(+) pump current when we included glutaredoxin 1 in patch pipette solutions to reverse glutathionylation. We conclude that transient K(+)-induced peak Na(+)-K(+) pump current reflects the effect

  18. Response of saliva Na/K ratio to changing Na supply of lactating cows under tropical conditions.

    Science.gov (United States)

    Thiangtum, Wandee; Schonewille, J Thomas; Verstegen, Martin Wa; Arsawakulsudhi, Supot; Rukkwamsuk, Theera; Hendriks, Wouter H

    2017-06-01

    Factorial determination of the sodium (Na) requirement of heat-stressed lactating cows is hindered by accurate estimates of the Na losses through sweat. Direct studies, therefore, may be needed requiring information on the time course of healthy animals to become Na depleted and the subsequent rate of repletion. The rate of Na depletion and subsequent rate of Na repletion with two levels of dietary Na to lactating dairy cows housed under tropical conditions were investigated using the salivary Na/K. The 12 lactating cows (salivary Na/K ratio 14.6) rapidly developed clinical signs of Na deficiency, including pica, polyuria and polydipsia, reduced body weight and reduced milk yield when fed a low-Na ration (0.33 g kg -1 dry matter (DM)) for 3 weeks. Deficiency symptoms were associated with a rapid decrease in salivary Na/K ratio to cows with NaCl to a ration concentration of 1.1 or 1.6 g Na kg -1 DM for 5 weeks did not restore salivary Na/K ratio to values of >6. A daily Na intake of heat-stressed lactating cows to a ration intake of 1.6 g Na kg -1 DM was insufficient to restore Na deficiency. One week was sufficient to deplete heat-stressed lactating cows of Na, allowing for rapid dose-response studies utilizing the salivary Na/K ratio as a parameter for Na status of cows under tropical conditions. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

  19. Water transport by the renal Na(+)-dicarboxylate cotransporter

    DEFF Research Database (Denmark)

    Meinild, A K; Loo, D D; Pajor, A M

    2000-01-01

    . This solute-coupled influx of water took place in the absence of, and even against, osmotic gradients. There was a strict stoichiometric relationship between Na(+), substrate, and water transport of 3 Na(+), 1 dicarboxylate, and 176 water molecules/transport cycle. These results indicate that the renal Na......This study investigated the ability of the renal Na(+)-dicarboxylate cotransporter, NaDC-1, to transport water. Rabbit NaDC-1 was expressed in Xenopus laevis oocytes, cotransporter activity was measured as the inward current generated by substrate (citrate or succinate), and water transport...... was monitored by the changes in oocyte volume. In the absence of substrates, oocytes expressing NaDC-1 showed an increase in osmotic water permeability, which was directly correlated with the expression level of NaDC-1. When NaDC-1 was transporting substrates, there was a concomitant increase in oocyte volume...

  20. Presoja notranjih kontrol pri obračunu davka na dodano vrednost na primeru "Podjetja x"

    OpenAIRE

    Majcen, Borut

    2016-01-01

    Poslovanje podjetja si je ob odsotnosti notranjih kontrol nemogoče predstavljati. Podjetja so podvržena raznim tveganjem, še posebej v današnjih razmerah globalnega poslovanja, ko se podjetja soočajo z vedno novimi izzivi, kar prinaša tudi nova tveganja. Najučinkovitejši ukrep za obvladovanje tveganj predstavlja vzpostavitev sistema notranjih kontrol. Obvladovanje tveganj pa ne poteka samo na ravni podjetja kot celote, ampak je prisotno na vseh področjih delovanja podjetja, torej tudi na p...

  1. Intracellular Na(+) and metabolic modulation of Na/K pump and excitability in the rat suprachiasmatic nucleus neurons.

    Science.gov (United States)

    Wang, Yi-Chi; Yang, Jyh-Jeen; Huang, Rong-Chi

    2012-10-01

    Na/K pump activity and metabolic rate are both higher during the day in the suprachiasmatic nucleus (SCN) that houses the circadian clock. Here we investigated the role of intracellular Na(+) and energy metabolism in regulating Na/K pump activity and neuronal excitability. Removal of extracellular K(+) to block the Na/K pump excited SCN neurons to fire at higher rates and return to normal K(+) to reactivate the pump produced rebound hyperpolarization to inhibit firing. In the presence of tetrodotoxin to block the action potentials, both zero K(+)-induced depolarization and rebound hyperpolarization were blocked by the cardiac glycoside strophanthidin. Ratiometric Na(+) imaging with a Na(+)-sensitive fluorescent dye indicated saturating accumulation of intracellular Na(+) in response to pump blockade with zero K(+). The Na(+) ionophore monensin also induced Na(+) loading and hyperpolarized the membrane potential, with the hyperpolarizing effect of monensin abolished in zero Na(+) or by pump blockade. Conversely, Na(+) depletion with Na(+)-free pipette solution depolarized membrane potential but retained residual Na/K pump activity. Cyanide inhibition of oxidative phosphorylation blocked the Na/K pump to depolarize resting potential and increase spontaneous firing in most cells, and to raise intracellular Na(+) levels in all cells. Nonetheless, the Na/K pump was incompletely blocked by cyanide but completely blocked by iodoacetate to inhibit glycolysis, indicating the involvement of both oxidative phosphorylation and glycolysis in fueling the Na/K pump. Together, the results indicate the importance of intracellular Na(+) and energy metabolism in regulating Na/K pump activity as well as neuronal excitability in the SCN neurons.

  2. NA49: lead-lead collision

    CERN Multimedia

    1996-01-01

    This is an image of an actual lead ion collision taken from tracking detectors on the NA49 experiment, part of the heavy ion project at CERN. These collisions produce a very complicated array of hadrons as the heavy ions break up. It is hoped that one of these collisions will eventually create a new state of matter known as quark-gluon plasma.

  3. Leitura na escola: um barco à deriva?

    Directory of Open Access Journals (Sweden)

    Teixeira, Marlene

    2008-01-01

    Full Text Available Este artigo busca, na teoria da enunciação de É. Benveniste, elementos para repensar o trabalho com a leitura na escola. Considera que, na discussão das noções gêmeas de forma e sentido, o autor formula uma concepção de significado que, de um lado, pode deter a interpretação à deriva, implicada na visão de leitura centrada no leitor, e, de outro lado, possibilita que se transcenda a idéia de que é pela decifração mdo código que se dá o processo de construção do significado. Conclui que, no processo de leitura, é sempre de um trabalho com a língua que se trata, trabalho que se renova a cada ato de aproximação do aluno com o texto, porque a língua é submetida ao ato de enunciação

  4. NA48: Wiring up for Change

    CERN Multimedia

    2001-01-01

    The NA48 Collaboration is rebuilding its drift chambers ready for the experiment to start up again this coming July. An intricate task involving the soldering of over 24,000 wires! The future of the NA48 experiment is coming right down to the wire, that is, the wires which the Collaboration is installing in the clean room of Hall 887 on the Prévessin site. Six days a week, technicians are working in shifts to rebuild the experiment's drift chambers. The original chambers were damaged when a section of a vacuum tube imploded at the end of 1999. A year ago, CERN gave the green light for this essential part of the spectrometer to be rebuilt, so the NA48 experiment, which studies CP violation (see box), still has a bright future ahead of it. Three years of data-taking ahead The NA48 experiment aims to penetrate the secrets of CP (Charge Parity) violation. Charge and parity are two parameters which distinguish a particle from an antiparticle. In other words, an electron possesses a negative electric ...

  5. Haalbaarheid voortijdige liberalisering na 1 april 2009

    NARCIS (Netherlands)

    Baarsma, B.

    2009-01-01

    Al geruime tijd worden door de politiek, postbedrijven en vakbonden gesprekken gevoerd over de liberalisering van de postmarkt. In april 2008 is door de sociale partners een beginselakkoord gesloten en november 2008 is een CAO opgesteld. Het is de bedoeling om binnen 3½ jaar na liberalisering ten

  6. Experiment NA57 at the CERN SPS

    Czech Academy of Sciences Publication Activity Database

    Antinori, F.; Balada, A.; Barbera, R.; Píška, Karel; Staroba, Pavel; Závada, Petr

    1999-01-01

    Roč. 25, - (1999), s. 473-479 ISSN 0954-3899 Institutional research plan: CEZ:AV0Z1010920 Keywords : NA57 * production of strange, multistrange particles * baryons, antibaryons * ultrarelativistic nucleus - nucleus collisions * SPS * strangeness enhancement * number of participants Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 1.620, year: 1999

  7. Pijn tijdens of na de wortelkanaalbehandeling

    NARCIS (Netherlands)

    Wesselink, P.R.

    2012-01-01

    Een wortelkanaalbehandeling kan pijn veroorzaken tijdens en/of na de behandeling. Tijdens de behandeling moet dan onderscheid worden gemaakt tussen pijn bij een pulpitis en pijn bij een necrotische pulpa. In beide gevallen kan die pijn effectief worden bestreden, afhankelijk van de toestand waarin

  8. Probing luminescence centers in Na rich feldspar

    DEFF Research Database (Denmark)

    Prasad, Amit Kumar; Lapp, Torben; Kook, Myung Ho

    2016-01-01

    our understanding of the luminescence mechanisms and recombination sites, in a sample of Na rich plagioclase feldspar (oligoclase). Both the UV and violet–blue emissions show resonant excitations arising from a distribution of energy levels. We propose, contrary to the general understanding...

  9. Acetylene diffusion in Na-Y zeolite

    Indian Academy of Sciences (India)

    ideal guest molecule to start with. Here we ... In that case the incoherent scattering law, Sinc(Q, ω), alone describes the dynamics. Q(=k−k0) is the .... The results of QENS measurements to study the diffusion of acetylene gas in zeolite. Na-Y at ...

  10. Therapy of hyperthyroidism with Na131I

    International Nuclear Information System (INIS)

    Kakehi, Hirotake; Furukawa, Takashi; Fukakusa, Shunichi; Futonaka, Hiroshi; Takahashi, Yuji

    1984-01-01

    Forty one patients of hyperthyroidism were treated with Na 131 I. Men and women are in the ratio 1:3.1. The ages of patients are between twenties and sixties and the forties are the highest in number. The observation period of clinical courses is between 1 and 8 years. The number of patients observed over 5 years are 51% of them and over 2 years are 83%. The treatment frequency is as follows: On 37 cases each one was treated once with Na 131 I. 2 cases twice, 1 case at 4 times in 3 years and 1 case at 5 times in 6 years. The treatment doses are between 4,000-6,000 rad (40-60 Gray). In the cases treated with the irradiation dose of 6,000 rad, we often saw hypothyroidism. In cases aiming 4,000-5,000 rad, there is a tendency of leaving hyperthyroidism unrecovered. In conclusion, the patients should be treated giving 4,000-5,000 rad or with Na 131 I doses of 3-6mCi. If the effects of the treatment are insufficient, the patients should be further treated with anti-thyroid drug or treated again with Na 131 I. As the result, there are at present 25 cases (61.0%) in normal status of the thyroid gland, 12 cases (29.2%) in hyperthyroidism and 4 cases (9.8%) in hypothyroidism totaling 41 cases in all. (author)

  11. Nucleotide binding to Na+/K+-ATPase

    Czech Academy of Sciences Publication Activity Database

    Kubala, Martin; Lánský, Zdeněk; Ettrich, R.; Plášek, J.; Teisinger, Jan; Amler, Evžen

    2005-01-01

    Roč. 272, č. S1 (2005), s. 191-191 E-ISSN 1742-4658. [FEBS Congress /30./ and IUBMB Conference /9./. 02.07.2005-07.07.2005, Budapest] Keywords : Na+/K+- ATPase * ATP binding * TNP-ATP Subject RIV: BO - Biophysics

  12. Concentratie gewasbeschermingsmiddelen na verhitting dompelbad bloembollen

    NARCIS (Netherlands)

    Bulle, A.A.E.; Lans, van der A.M.; Aanholt, van J.T.M.

    2014-01-01

    De meest gebruikte methode van ontsmetting van bloembollen en –knollen is een dompeling in een mix van fungiciden. In het proces van bolontsmetting worden partijen bollen na elkaar ontsmet in hetzelfde dompelbad. Met een partij bollen kan een dompelbad behoorlijk vervuild raken met bijvoorbeeld

  13. Laser trapping of 21Na atoms

    International Nuclear Information System (INIS)

    Lu, Zheng-Tian.

    1994-09-01

    This thesis describes an experiment in which about four thousand radioactive 21 Na (t l/2 = 22 sec) atoms were trapped in a magneto-optical trap with laser beams. Trapped 21 Na atoms can be used as a beta source in a precision measurement of the beta-asymmetry parameter of the decay of 21 Na → 21 Ne + Β + + v e , which is a promising way to search for an anomalous right-handed current coupling in charged weak interactions. Although the number o trapped atoms that we have achieved is still about two orders of magnitude lower than what is needed to conduct a measurement of the beta-asymmetry parameter at 1% of precision level, the result of this experiment proved the feasibility of trapping short-lived radioactive atoms. In this experiment, 21 Na atoms were produced by bombarding 24 Mg with protons of 25 MeV at the 88 in. Cyclotron of Lawrence Berkeley Laboratory. A few recently developed techniques of laser manipulation of neutral atoms were applied in this experiment. The 21 Na atoms emerging from a heated oven were first transversely cooled. As a result, the on-axis atomic beam intensity was increased by a factor of 16. The atoms in the beam were then slowed down from thermal speed by applying Zeeman-tuned slowing technique, and subsequently loaded into a magneto-optical trap at the end of the slowing path. The last two chapters of this thesis present two studies on the magneto-optical trap of sodium atoms. In particular, the mechanisms of magneto-optical traps at various laser frequencies and the collisional loss mechanisms of these traps were examined

  14. Učinak video igre "Flappy Bird" na adolescente

    OpenAIRE

    Horvat, Marija

    2018-01-01

    Ovaj diplomski rad nastoji predstaviti uvid u učinke videoigre Flappy Bird na adolescente, fokusirajući se pritom na to potiče li ona nasilno ponašanje te nastoji odgovoriti na pitanje koliko je ta videoigra bila popularna među adolescentima u Hrvatskoj te po čemu je smatraju posebnom, tj. specifičnom. U tu svrhu provedeno je anketno istraživanje, a isti anketni upitnik proveden je na terenu i putem interneta te su uspoređeni rezultati. Anketni upitnik konstruiran je na način da se prvi dio u...

  15. On the Stability of NaO2 in Na-O2 Batteries.

    Science.gov (United States)

    Liu, Chenjuan; Carboni, Marco; Brant, William R; Pan, Ruijun; Hedman, Jonas; Zhu, Jiefang; Gustafsson, Torbjörn; Younesi, Reza

    2018-04-25

    Na-O 2 batteries are regarded as promising candidates for energy storage. They have higher energy efficiency, rate capability, and chemical reversibility than Li-O 2 batteries; in addition, sodium is cheaper and more abundant compared to lithium. However, inconsistent observations and instability of discharge products have inhibited the understanding of the working mechanism of this technology. In this work, we have investigated a number of factors that influence the stability of the discharge products. By means of in operando powder X-ray diffraction study, the influence of oxygen, sodium anode, salt, solvent, and carbon cathode were investigated. The Na metal anode and an ether-based solvent are the main factors that lead to the instability and decomposition of NaO 2 in the cell environment. This fundamental insight brings new information on the working mechanism of Na-O 2 batteries.

  16. Regeneration of plantlets under NaCl stress from NaN3 treated ...

    African Journals Online (AJOL)

    use

    2011-11-16

    Nov 16, 2011 ... plant regeneration under NaCl stressed conditions was assessed in some sugarcane ( ... cell is a useful work for the establishment of pure form of ... balance. The relative water contents (RWC) were calculated .... J. Life Sci.

  17. Equilibrium chemical transformations in NaPO3 + NaCl melts

    International Nuclear Information System (INIS)

    Kovarskaya, E.N.; Rodionov, Yu.I.

    1988-01-01

    Because of the problems of the burial of solidified radioactive wastes into different geological rock formations, in particular into massives of rock-salt, the state of molten polyphosphate-chloride mixtures (taking into account the chemical character of the interaction of their components) for a prolonged period of time. The equilibrium products of the reaction in the NaPO 3 -NaCl system were studied in melts in air in the composition range of 30-70 mole % NaCl. It was shown that with increase in the NaCl content in the mixtures, the polyphosphate gradually depolymerizes to sodium tri-, di-, and monophosphates, and the composition of the equilibrium melts is dependent only on the ratio between the components in the initial molten mixtures. The time until the equilibrium is attained is shorter, the higher is the experimental temperature

  18. Transmural gradients in Na/K pump activity and [Na+]I in canine ventricle.

    Science.gov (United States)

    Gao, J; Wang, W; Cohen, I S; Mathias, R T

    2005-09-01

    There are well-documented differences in ion channel activity and action potential shape between epicardial (EPI), midmyocardial (MID), and endocardial (ENDO) ventricular myocytes. The purpose of this study was to determine if differences exist in Na/K pump activity. The whole cell patch-clamp was used to measure Na/K pump current (I(P)) and inward background Na(+)-current (I(inb)) in cells isolated from canine left ventricle. All currents were normalized to membrane capacitance. I(P) was measured as the current blocked by a saturating concentration of dihydro-ouabain. [Na(+)](i) was measured using SBFI-AM. I(P)(ENDO) (0.34 +/- 0.04 pA/pF, n = 17) was smaller than I(P)(EPI) (0.68 +/- 0.09 pA/pF, n = 38); the ratio was 0.50 with I(P)(MID) being intermediate (0.53 +/- 0.13 pA/pF, n = 19). The dependence of I(P) on [Na(+)](i) or voltage was essentially identical in EPI and ENDO (half-maximal activation at 9-10 mM [Na(+)](i) or approximately -90 mV). Increasing [K(+)](o) from 5.4 to 15 mM caused both I(P)(ENDO) and I(P)(EPI) to increase, but the ratio remained approximately 0.5. I(inb) in EPI and ENDO were nearly identical ( approximately 0.6 pA/pF). Physiological [Na(+)](i) was lower in EPI (7 +/- 2 mM, n = 31) than ENDO (12 +/- 3 mM, n = 29), with MID being intermediate (9 +/- 3 mM, n = 22). When cells were paced at 2 Hz, [Na(+)](i) increased but the differences persisted (ENDO 14 +/- 3 mM, n = 10; EPI 9 +/- 2 mM, n = 10; and MID intermediate, 11 +/- 2 mM, n = 9). Based on these results, the larger I(P) in EPI appears to reflect a higher maximum turnover rate, which implies either a larger number of active pumps or a higher turnover rate per pump protein. The transmural gradient in [Na(+)](i) means physiological I(P) is approximately uniform across the ventricular wall, whereas transporters that utilize the transmembrane electrochemical gradient for Na(+), such as Na/Ca exchange, have a larger driving force in EPI than ENDO.

  19. Isotope separation of 22Na and 24Na with using light induced drift effect

    International Nuclear Information System (INIS)

    Hradecny, C.; Tethal, T.; Ermolaev, I.M.; Zemlyanoj, S.G.; Zuzaan, P.

    1993-01-01

    The LIDIS (Light Drift Isotope Separation) separator without a gas flow is discussed. It is shown, that atomization degree of the separated isotopes limited real separation coefficient. The better buffer gas purification allowed to increase the experimental separation factor of 22 Na and 24 Na isotopes up to 25. The new experimental set up allow to increase the separation efficiency up to 50%. 12 refs.; 5 figs

  20. Intracellular Na+ regulation of Na+ pump sites in cultured vascular smooth muscle cells

    International Nuclear Information System (INIS)

    Allen, J.C.; Navran, S.S.; Seidel, C.L.; Dennison, D.K.; Amann, J.M.; Jemelka, S.K.

    1989-01-01

    Enzymatically dispersed cells from canine saphenous vein and femoral artery were grown in fetal calf serum and studied at day 0 (freshly dispersed) through confluence in primary culture. Intracellular Na levels (Nai), but not intracellular K (Ki), were increased after 24 h in culture and then decreased to a steady state by 4 days. Na+ pump site number [( 3 H] ouabain binding) increased through day 3 and remained elevated. Nai was still elevated at 2 days when the Na+ pump site number began to increase. Total pump turnover (maximum ouabain-inhibited 86 Rb uptake) reflected the increase in Na+ pump site number. These key events precede the observed increases in both protein production and cellular proliferation. If the same cells are maintained in defined medium, without fetal calf serum, Nai, Ki, and the number of [ 3 H]ouabain binding sites do not change with time. These data are consistent with the suggestion that the initial mitogenic response of vascular smooth muscle cells to fetal calf serum involves an increased Na+ influx, and a Nai accumulation, caused by low Na+ pump density. The synthesis of new pump sites effects a decrease in the accumulated Nai, which may be related to cell proliferation

  1. Vliv mikroflóry na senzorické vlastnosti vína

    OpenAIRE

    Petrášová, Ludmila

    2014-01-01

    Tato bakalářská práce se zabývá vlivem mikroflóry na senzorické vlastnosti vína. Teoretická část informuje o botanickém popisu hroznů vína Veltlínské zelené, dále o jeho složení, o technologii zpracování bílého vína a o vlivu kvasinek na aromatický profil vína. V další části popisuje metodu stanovení aromaticky aktivních látek pomocí plynové chromatografie v kombinaci s mikroextrakcí tuhou fází (SPME-GC). Cílem experimentální části bylo proměřit vzorky 4 různých moštů odrůdy Veltlínské zelené...

  2. Active transport of Na/sup +/ by reconstituted Na,K-ATPase

    Energy Technology Data Exchange (ETDEWEB)

    Boldyrev, A.A.; Svinukhova, I.A.

    1987-02-20

    The ability of ATP, CTP, ITP, GTP, and UTP to support ouabain-sensitive accumulation of Na/sup +/ by proteoliposomes with a reconstituted Na/K-pump was investigated. At a low (Na/sup +/)/(K/sup +/) ratio in the medium (20 mM/50 mM), a correlation is observed between the proton-accepting capacity of the nucleotide and its effectiveness as a substrate of active transport. To test the hypothesis of the importance of the presence of a negative charge in the 1-position of the purine (3-pyrimidine) base of the nucleotide for mutual transitions between the Na- and K-conformations of Na,K-ATPase they used two analogs of ATP: N/sub 1/-hydroxy-ATP, possessing proton acceptor capacity, and N/sub 1/-methoxy-ATP, in the molecule of which the negative charge is quenched by a methyl group. The first substrate supports active accumulation of Na/sup +/ in proteoliposomes at the same rate as ATP, whereas the second substrate is relatively ineffective.

  3. Transport of Na48 Drift Chambers to Dubna

    CERN Multimedia

    GOLOVATYUK, V

    2010-01-01

    On 22 July, in the occasion of the departure of the Na48 Drift Chambers from CERN, Mikhail Itkis (acting Director of the JIINR) and Rolf Heuer (CERN Director General) visited the NA62 experimental area.

  4. Regulation of Epithelial Sodium Transport via Epithelial Na+ Channel

    Science.gov (United States)

    Marunaka, Yoshinori; Niisato, Naomi; Taruno, Akiyuki; Ohta, Mariko; Miyazaki, Hiroaki; Hosogi, Shigekuni; Nakajima, Ken-ichi; Kusuzaki, Katsuyuki; Ashihara, Eishi; Nishio, Kyosuke; Iwasaki, Yoshinobu; Nakahari, Takashi; Kubota, Takahiro

    2011-01-01

    Renal epithelial Na+ transport plays an important role in homeostasis of our body fluid content and blood pressure. Further, the Na+ transport in alveolar epithelial cells essentially controls the amount of alveolar fluid that should be kept at an appropriate level for normal gas exchange. The epithelial Na+ transport is generally mediated through two steps: (1) the entry step of Na+ via epithelial Na+ channel (ENaC) at the apical membrane and (2) the extrusion step of Na+ via the Na+, K+-ATPase at the basolateral membrane. In general, the Na+ entry via ENaC is the rate-limiting step. Therefore, the regulation of ENaC plays an essential role in control of blood pressure and normal gas exchange. In this paper, we discuss two major factors in ENaC regulation: (1) activity of individual ENaC and (2) number of ENaC located at the apical membrane. PMID:22028593

  5. An enhancement to the NA4 gear vibration diagnostic parameter

    Science.gov (United States)

    Decker, Harry J.; Handschuh, Robert F.; Zakrajsek, James J.

    1994-01-01

    A new vibration diagnostic parameter for health monitoring of gears, NA4*, is proposed and tested. A recently developed gear vibration diagnostic parameter NA4 outperformed other fault detection methods at indicating the start and initial progression of damage. However, in some cases, as the damage progressed, the sensitivity of the NA4 and FM4 parameters tended to decrease and no longer indicated damage. A new parameter, NA4* was developed by enhancing NA4 to improve the trending of the parameter. This allows for the indication of damage both at initiation and also as the damage progresses. The NA4* parameter was verified and compared to the NA4 and FM4 parameters using experimental data from single mesh spur and spiral bevel gear fatigue rigs. The primary failure mode for the test cases was naturally occurring tooth surface pitting. The NA4* parameter is shown to be a more robust indicator of damage.

  6. Agmag Igbo dka Ngwar n'kwalite Ezi Nchekwa na Nkwsiike haobodo

    African Journals Online (AJOL)

    Ka Najira nwerechara onwe ya n'af 1960, olileanya tt mamala ya b na ihe ga-adz mma. Mana ka oge na-aga, a chptara na ihe na-akawanye nj. Usoro chch d iche iche daptara. Nd am na nd nkt achala mana nd gara n'ihu na-akawanye nj. O bu ihe doro anya na chch ha b nke nchgbu na fnfju akpa. N'agbanyegh na ...

  7. Angiotensin II-induced hypertension increases plasma membrane Na pump activity by enhancing Na entry in rat thick ascending limbs.

    Science.gov (United States)

    Gonzalez-Vicente, Agustin; Garvin, Jeffrey L

    2013-11-01

    Thick ascending limbs (TAL) reabsorb 30% of the filtered NaCl load. Na enters the cells via apical Na-K-2Cl cotransporters and Na/H exchangers and exits via basolateral Na pumps. Chronic angiotensin II (ANG II) infusion increases net TAL Na transport and Na apical entry; however, little is known about its effects on the basolateral Na pump. We hypothesized that in rat TALs Na pump activity is enhanced by ANG II-infusion, a model of ANG II-induced hypertension. Rats were infused with 200 ng·kg(-1)·min(-1) ANG II or vehicle for 7 days, and TAL suspensions were obtained. We studied plasma membrane Na pump activity by measuring changes in 1) intracellular Na (Nai) induced by ouabain; and 2) ouabain-sensitive oxygen consumption (QO2). We found that the ouabain-sensitive rise in Nai in TALs from ANG II-infused rats was 12.8 ± 0.4 arbitrary fluorescent units (AFU)·mg(-1)·min(-1) compared with only 9.9 ± 1.1 AFU·mg(-1)·min(-1) in controls (P Na pump expression, the number of Na pumps in the plasma membrane, or the affinity for Na. When furosemide (1.1 mg·kg(-1)·day(-1)) was coinfused with ANG II, no increase in plasma membrane Na pump activity was observed. We concluded that in ANG II-induced hypertension Na pump activity is increased in the plasma membrane of TALs and that this increase is caused by the chronically enhanced Na entry occurring in this model.

  8. Rescue of Na+ affinity in aspartate 928 mutants of Na+,K+-ATPase by secondary mutation of glutamate 314.

    Science.gov (United States)

    Holm, Rikke; Einholm, Anja P; Andersen, Jens P; Vilsen, Bente

    2015-04-10

    The Na(+),K(+)-ATPase binds Na(+) at three transport sites denoted I, II, and III, of which site III is Na(+)-specific and suggested to be the first occupied in the cooperative binding process activating phosphorylation from ATP. Here we demonstrate that the asparagine substitution of the aspartate associated with site III found in patients with rapid-onset dystonia parkinsonism or alternating hemiplegia of childhood causes a dramatic reduction of Na(+) affinity in the α1-, α2-, and α3-isoforms of Na(+),K(+)-ATPase, whereas other substitutions of this aspartate are much less disruptive. This is likely due to interference by the amide function of the asparagine side chain with Na(+)-coordinating residues in site III. Remarkably, the Na(+) affinity of site III aspartate to asparagine and alanine mutants is rescued by second-site mutation of a glutamate in the extracellular part of the fourth transmembrane helix, distant to site III. This gain-of-function mutation works without recovery of the lost cooperativity and selectivity of Na(+) binding and does not affect the E1-E2 conformational equilibrium or the maximum phosphorylation rate. Hence, the rescue of Na(+) affinity is likely intrinsic to the Na(+) binding pocket, and the underlying mechanism could be a tightening of Na(+) binding at Na(+) site II, possibly via movement of transmembrane helix four. The second-site mutation also improves Na(+),K(+) pump function in intact cells. Rescue of Na(+) affinity and Na(+) and K(+) transport by second-site mutation is unique in the history of Na(+),K(+)-ATPase and points to new possibilities for treatment of neurological patients carrying Na(+),K(+)-ATPase mutations. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  9. Characterization of Na+-linked and Na+-independent Cl-/HCO3- exchange systems in Chinese hamster lung fibroblasts

    International Nuclear Information System (INIS)

    Cassel, D.; Scharf, O.; Rotman, M.; Cragoe, E.J. Jr.; Katz, M.

    1988-01-01

    The PS120 variant of Chinese hamster lung fibroblasts which lacks Na + /H + exchange activity was used to investigate bicarbonate transport systems and their role in intracellular pH (pH/sub i/) regulation. When pH/sub i/ was decreased by acid load, bicarbonate caused pH/sub i/ increase and stimulated 36 Cl - efflux from the cells, both in a Na + -dependent manner. These results together with previous findings that bicarbonate stimulates 22 Na + uptake in PS120 cells demonstrate the presence of a Na + -linked Cl - /HCO 3 - exchange system. In cells with normal initial pH/sub i/, bicarbonate caused Na + -independent pH/sub i/ increase in Cl - -free solutions and stimulated Na + -independent 36 Cl - efflux, indicating that a Na + -independent Cl - /HCO 3 - exchanger is also present in the cell. Na + -linked and Na + -independent Cl - /HCO 3- exchange is apparently mediated by two distinct systems, since a [(tetrahydrofluorene-7-yl)oxy]acetic acid derivative selectively inhibits the Na + -independent exchanger. An additional distinctive features is a 10-fold lower affinity for chloride of the Na + -linked exchanger. The Na + -linked and Na + -independent Cl - /HCO 3 - exchange systems are likely to protect the cell from acid and alkaline load, respectively

  10. The two C-terminal tyrosines stabilize occluded Na/K pump conformations containing Na or K ions.

    Science.gov (United States)

    Vedovato, Natascia; Gadsby, David C

    2010-07-01

    Interactions of the three transported Na ions with the Na/K pump remain incompletely understood. Na/K pump crystal structures show that the extended C terminus of the Na,K-adenosine triphosphatase (ATPase) alpha subunit directly contacts transmembrane helices. Deletion of the last five residues (KETYY in almost all Na/K pumps) markedly lowered the apparent affinity for Na activation of pump phosphorylation from ATP, a reflection of cytoplasmic Na affinity for forming the occluded E1P(Na3) conformation. ATPase assays further suggested that C-terminal truncations also interfere with low affinity Na interactions, which are attributable to extracellular effects. Because extracellular Na ions traverse part of the membrane's electric field to reach their binding sites in the Na/K pump, their movements generate currents that can be monitored with high resolution. We report here electrical measurements to examine how Na/K pump interactions with extracellular Na ions are influenced by C-terminal truncations. We deleted the last two (YY) or five (KESYY) residues in Xenopus laevis alpha1 Na/K pumps made ouabain resistant by either of two kinds of point mutations and measured their currents as 10-mM ouabain-sensitive currents in Xenopus oocytes after silencing endogenous Xenopus Na/K pumps with 1 microM ouabain. We found the low affinity inhibitory influence of extracellular Na on outward Na/K pump current at negative voltages to be impaired in all of the C-terminally truncated pumps. Correspondingly, voltage jump-induced transient charge movements that reflect pump interactions with extracellular Na ions were strongly shifted to more negative potentials; this signals a several-fold reduction of the apparent affinity for extracellular Na in the truncated pumps. Parallel lowering of Na affinity on both sides of the membrane argues that the C-terminal contacts provide important stabilization of the occluded E1P(Na3) conformation, regardless of the route of Na ion entry into the

  11. The rapid-onset dystonia parkinsonism mutation D923N of the Na+, K+-ATPase alpha3 isoform disrupts Na+ interaction at the third Na+ site.

    Science.gov (United States)

    Einholm, Anja Pernille; Toustrup-Jensen, Mads S; Holm, Rikke; Andersen, Jens Peter; Vilsen, Bente

    2010-08-20

    Rapid-onset dystonia parkinsonism (RDP), a rare neurological disorder, is caused by mutation of the neuron-specific alpha3-isoform of Na(+), K(+)-ATPase. Here, we present the functional consequences of RDP mutation D923N. Relative to the wild type, the mutant exhibits a remarkable approximately 200-fold reduction of Na(+) affinity for activation of phosphorylation from ATP, reflecting a defective interaction of the E(1) form with intracellular Na(+). This is the largest effect on Na(+) affinity reported so far for any Na(+), K(+)-ATPase mutant. D923N also affects the interaction with extracellular Na(+) normally driving the E(1)P to E(2)P conformational transition backward. However, no impairment of K(+) binding was observed for D923N, leading to the conclusion that Asp(923) is specifically associated with the third Na(+) site that is selective toward Na(+). The crystal structure of the Na(+), K(+)-ATPase in E(2) form shows that Asp(923) is located in the cytoplasmic half of transmembrane helix M8 inside a putative transport channel, which is lined by residues from the transmembrane helices M5, M7, M8, and M10 and capped by the C terminus, recently found involved in recognition of the third Na(+) ion. Structural modeling of the E(1) form of Na(+), K(+)-ATPase based on the Ca(2+)-ATPase crystal structure is consistent with the hypothesis that Asp(923) contributes to a site binding the third Na(+) ion. These results in conjunction with our previous findings with other RDP mutants suggest that a selective defect in the handling of Na(+) may be a general feature of the RDP disorder.

  12. Jogos teatrais na escola pública

    Directory of Open Access Journals (Sweden)

    Ricardo Ottoni Vaz Japiassu

    1998-07-01

    Full Text Available O artigo apresenta os resultados parciais de pesquisa etnográfica que acompanha aspectos do desenvolvimento cultural de pré-adolescentes com a linguagem teatral em classe multisseriada, através do ensino regular de Teatro, em escola de ensino fundamental da rede pública estadual de São Paulo-SP. Os dados obtidos permitem afirmar que a linguagem cênica contribui na conscientização das novas possibilidades de significação da palavra na prática discursiva.The article shows partial results of ethnographic research in which kids are observed in their cultural development process with theater classes in public school education in São Paulo/Brazil. The data colected indicates that the use of theater games in school education helps students to be aware of a word’s new meaning possibilities in human comunication.

  13. Luz e tempo na melancolia I

    Directory of Open Access Journals (Sweden)

    Cláudio Soares Braga Furtado

    2009-12-01

    Full Text Available A comparação entre as artes possibilita figurar o tempo como elemento comum entre a gravura renascentista de Dürer, a escultura romana de Laocoonte e o conto de Guimarães Rosa. A partir da leitura dessas artes distantes em forma, meios, época e lugar, descobrem-se mistérios aludidos em sutis sinais, que, se ainda não despertos na consciência criativa, estimulam interpretações. O papel da luz como unificadora das entidades tempo/espaço restabelece o princípio clássico da ut pictura poesis na leitura moderna.

  14. NA62 experiment at CERN SPS

    Directory of Open Access Journals (Sweden)

    Kozhuharov Venelin

    2014-01-01

    Full Text Available The NA62 experiment at SPS is a continuation of the long standing CERN kaon physics program. The high statistics and the unprecedent precision allow to probe the Standard Model and test the description of the strong interactions at low energy. The final results on the the lepton universality test by measuring the ratio RK = Γ(K+ → e+ν/Γ(K+ → µ+ν and the study of the K± → π±γγ decay are presented. The major goal of the NA62 experiment is to perform a measurement of the Br(K+ → π+νν̄ with a precision of 10% in two years of data taking. The detector setup together with the analysis technique is described.

  15. O Personal Trainer na Perspectiva do Marketing

    Directory of Open Access Journals (Sweden)

    Cibele Biehl Bossle

    2011-03-01

    Full Text Available Esse estudo apresenta mapeamento das referências dedicadas à formação do personal trainer em bases de dados eletrônicas. Essa garimpagem revelou baixa produção científica sobre o assunto e mostrou que na literatura sobre personal trainer predominam livros com linguagem corrente no mundo dos negócios. Esses achados nos levaram a indagar sobre a força do discurso físico-empresarial, especialmente o marketing, na constituição desta ocupação profissional. Jeremy Rifkin, Zygmunt Bauman, Paula Sibilia e Denise Sant'Anna permitiram visualizar que o marketing dirigido ao personal trainer tem como tarefa reinventar, ressignificar e "repaginar" esta modalidade de serviço em nome da sobrevivência no disputado mercado da vida ativa.

  16. Algoritmo de lanczos na variedade de grassmann

    OpenAIRE

    Lopes, Ana Paula Ferreira Fernandes; Viamonte, Ana Júlia; Pascoal, António José

    2008-01-01

    O problema do cálculo de valores próprios, vectores próprios e subespaços invariantes está presente em áreas tão diversas como Engenharia, Física, Ciências de Computação e Matemática. Considerando a importância deste problema em tantas aplicações práticas, não é de surpreender que tenha sido e continue a ser objecto de intensa investigação, dando corpo a uma literatura muito vasta. Desenvolvemos um novo algoritmo de Lanczos na variedade de Grassmann. Este trabalho surgiu na ...

  17. Kaizen: Uma Metodologia Inovadora na Siderurgia

    Directory of Open Access Journals (Sweden)

    Hericson Estanislau Prata

    2017-04-01

    Full Text Available A racionalização do processo produtivo industrial, por meio da redução dos desperdícios e da modernização do processo produtivo, com a adoção do Sistema Toyota de Produção (Produção Enxuta, tem sido adotada por uma parte importante das indústrias no mundo. O objetivo deste artigo é descrever essa metodologia empregada pelo grupo de melhoria de fase intensiva adotado na Vallourec Tubos do Brasil S.A. Como resultado, verificou-se que o processo utilizado para a implantação de mudanças em curto prazo foi a semana intensiva, também conhecida como evento Kaizen na indústria automotiva.

  18. The NA60 experiment readout architecture

    CERN Document Server

    Floris, M; Usai, G L; David, A; Rosinsky, P; Ohnishi, H

    2004-01-01

    The NA60 experiment was designed to identify signatures of a new state of matter, the Quark Gluon Plasma, in heavy-ion collisions at the CERN Super Proton Synchroton. The apparatus is composed of four main detectors: a muon spectrometer (MS), a zero degree calorimeter (ZDC), a silicon vertex telescope (VT), and a silicon microstrip beam tracker (BT). The readout of the whole experiment is based on a PCI architecture. The basic unit is a general purpose PCI card, interfaced to the different subdetectors via custom mezzanine cards. This allowed us to successfully implement several completely different readout protocols (from the VME like protocol of the MS to the custom protocol of the pixel telescope). The system was fully tested with proton and ion beams, and several million events were collected in 2002 and 2003. This paper presents the readout architecture of NA60, with particular emphasis on the PCI layer common to all the subdetectors. (16 refs).

  19. Urgências reprodutivas na cadela

    OpenAIRE

    Costa, Teresa Isabel Rodrigues da

    2010-01-01

    Dissertação de Mestrado Integrado em Medicina Veterinária As urgências reprodutivas ocorrem com frequência na prática clínica, estando o seu desfecho favorável associado a um diagnóstico e intervenção céleres. Na cadela, consideram-se urgências reprodutivas a distócia, a piómetra, o prolapso uterino, a torção uterina, a tetania puerperal, a metrite e a mastite. Esta dissertação tem por base a análise dos dados referentes à casuística de urgências reprodutivas em cadelas veri...

  20. NA35: sulphur-gold collision

    CERN Multimedia

    1991-01-01

    In this image the real particles produced by the collision of a 6400 GeV sulphur ion with a gold target can be seen as they pass through a streamer chamber. Streamer chambers consist of a gas chamber through which a strong pulsed electric field is passed, creating sparks as a charged particle passes through it. The NA35 experiment, which was in operation in the 1980s, was part of CERN's ongoing heavy ion project.

  1. New NA22 results on correlations

    International Nuclear Information System (INIS)

    De Wolf, E.A.

    1993-01-01

    Recent NA22 results from π + p and K + p inelastic interactions at √s = 22 GeV on invariant-mass and Q 2 -dependence of two- and three-particle factorial cumulants are discussed in relation to earlier intermittency studies. The absence of Bose-Einstein type correlations among identical particles, and too large resonance production rates, are responsible for the strong disagreements of models with intermittency data. 6 figs., 17 refs

  2. O legado grego na terminologia gramatical brasileira

    Directory of Open Access Journals (Sweden)

    Maria Helena de Moura Neves

    2011-12-01

    Full Text Available Este estudo tem como objetivo pesquisar a existência de um legado grego terminológico na organização gramatical brasileira, considerando que a gramática incipiente grega é a fonte da nossa gramática, por via da gramática latina, e que o recorte de campo que ela preparou é um ponto de referência para o estudo da evolução do pensamento ocidental sobre a linguagem. A orientação teórico-metodológica se assenta na Linguística Histórica, na linha que orientou a ampla pesquisa sobre a emergência da gramática no Ocidente que constitui a fonte das informações que aqui se organizam (NEVES, 2005. As reflexões dirigem-se especialmente para o exame da nomenclatura, entendendo que ela mapeia conceptualmente o conjunto das posições assumidas, e em geral mantidas, que merecem apreciação. Entre outras coisas o exame opôs: termos gregos legados na corrente contínua do pensamento gramatical a termos gregos introduzidos posteriormente; termos transliterados do grego a termos decalcados da tradução latina. Além disso, verificaram-se casos de alteração de nome com manutenção de conceito, e casos de alteração de conceito para um nome conservado. De todo modo, o exame da nomenclatura revela a indiscutível existência de um legado grego à organização da gramática portuguesa.

  3. Isovector magnetic dipole transition in 22Na

    International Nuclear Information System (INIS)

    Fifield, L.K.; Poletti, A.R.; Radford, D.C.

    1980-01-01

    The mean life of the 657 keV 0 + , T = 1 level in 22 Na for the radiative decay to the 583 keV 1 + , T = 0 level has been measured as tau = (27.1 +- 1.2)ps. A modification of the recoil-distance method (RDM) was used. In addition, the mean life of the 891 keV level in the same nucleus was remeasured to give tau = (14.1 +- 0.5)ps. (author)

  4. Prototype calorimeters for the NA3 experiment

    CERN Multimedia

    1975-01-01

    The NA3 Experiment was set-up on the North Area of the SPS by the CERN/ Ecole Polytechnique/College de France/ Orsay/Saclay Collaboration, to study high transverse momentum leptons and hadrons from hadron collisions. The calorimeters measured the energy of hadrons (prototype on the right) and leptons (prototype on the left). They used a new type of plastic scintillator (plexipop). (see CERN Courier of November 1975) energy (prototype on the right)

  5. The NA48 liquid krypton calorimeter

    CERN Document Server

    Gorini, B

    1997-01-01

    The NA48 collaboration goal is to measure the CP violation parameter Re(ɛl/ɛ) at the level of 2 × 10−4. The neutral Kaon decays will be reconstructed by an electromagnetic liquid Krypton calorimeter with fine granularity and a volume almost totally sensible, to obtain excellent position and energy resolution, as well as time resolution. A description of the detector, results from tests of a prototype and the status of the final calorimeter are reported.

  6. Maendeleo ya Fasihi ya Kiswahili ya Watoto nchini Tanzania na ...

    African Journals Online (AJOL)

    Fasihi ya Kiswahili ya watoto kama taaluma haina muda mrefu katika historia ya fasihi ya Kiswahili. Ikilinganishwa na fasihi ya watu wazima ambayo ilianza muda mrefu, na pia tafiti nyingi kufanyika katika mataifa mengi, fasihi ya watoto inaonekana kuwa imetelekezwa kwa muda mrefu kutokana na kutokupewa umuhimu ...

  7. Dhima za Mbinu Linganishi katika Kuhusisha Lugha na Lahaja ...

    African Journals Online (AJOL)

    Lengo la makala hii ni kujadili dhima za Mbinu Linganishi katika kuhusisha lugha na lahaja. Data za makala hii zilikusanywa kwa kutumia mbinu mbalimbali ambazo ni usaili, ushuhudiaji, hojaji na majadiliano katika majopo. Utafiti ulifanyika Tanzania Bara hususan Mkoani Mtwara na Tanzania Visiwani katika maeneo ya ...

  8. VARSTVO DOSTOJANSTVA DELAVCA IN JAVNEGA USLUŽBENCA NA DELU

    OpenAIRE

    Trstenjak, Jasna

    2011-01-01

    V magistrski nalogi sem želela proučiti varstvo dostojanstva delavca in javnega uslužbenca na delu, saj menim, da je to ključen dejavnik v delovnem razmerju vsakega posameznika, prav tako ima neposreden vpliv na konkurenčno sposobnost kot tudi na stroške dela, tako v javnem kot v zasebnem sektorju.

  9. Efficacy of 22Na turnover in ecopbysiological studies of carnivores

    African Journals Online (AJOL)

    Efficacy of 22Na turnover in ecopbysiological studies of carnivores. loS. Wilkinson and J.D. Skinner*. Mammal Research Institute, University of Pretoria, Pretoria, 0002 Republic of South Africa. Received 8 December 1986; accepted 11 August 1987. 22Na turnover rates gave overestimates of mean 23Na intake in both ...

  10. UREDITEV SPOLNEGA NADLEGOVANJA NA DELOVNEM MESTU V REPUBLIKI SLOVENIJI

    OpenAIRE

    Golavšek, Nastja

    2009-01-01

    V diplomski nalogi je predstavljena problematika spolnega nadlegovanja na delovnem mestu. Spolno nadlegovanje je nezaželeno ravnanje spolne narave ali drugo ravnanje, temelječe na spolu, ki ogroža dostojanstvo žensk in moških na delovnem mestu

  11. Muundo wa Mashairi katika Diwani ya Mnyampala (1965) na Nafasi ...

    African Journals Online (AJOL)

    Makala hii pia inadadisi namna mbinu za kimuundo zilivyofanikisha usawiri na ubainishaji wa falsafa ya mtunzi kuhusu ushairi wa Kiswahili na nafasi ya ushairi katika jamii. Makala imeanza kwa kugusia usuli wa historia ya ushairi wa Kiswahili, historia fupi ya maisha ya Mathias Mnyampala na nadharia yake kuhusu ...

  12. Explosive phenomena in heavily irradiated NaCl

    NARCIS (Netherlands)

    denHartog, HW; Vainshtein, DI; Matthews, GE; Williams, RT

    1997-01-01

    In heavily irradiated NaCl crystals explosive phenomena can be initiated during irradiation or afterwards when samples are heated to temperatures between 100 and 250 degrees C. During irradiation of NaCl Na and Cl-2 precipitates and void structures are produced along with the accumulation of stored

  13. NaI(Tl) response functions

    International Nuclear Information System (INIS)

    Vega C, H. R.; Ortiz R, J. M.; Benites R, J. L.; De Leon M, H. A.

    2015-09-01

    The response functions of a NaI(Tl) detector have been estimated using Monte Carlo methods. Response functions were calculated for monoenergetic photon sources (0.05 to 3 MeV). Responses were calculated for point-like sources and for sources distributed in Portland cement cylinders. The responses were used to calculate the efficiency functions in term of photon energy. Commonly, sources used for calibration are point-like, and eventually sources to be measured have different features. In order to use the calibrated sources corrections due to solid angle, self-absorption and scattering, must be carried out. However, some of these corrections are not easy to perform. In this work, the calculated responses were used to estimate the detector efficiency of point-like sources, and sources distributed in Portland type cement. Samples of Portland paste were prepared and were exposed to photoneutrons produced by a 15 MV linac. Some of the elements in the cement were activated producing γ-emitting radionuclides that were measured with a NaI(Tl) gamma-ray spectrometer, that was calibrated with point-like sources. In order to determine the specific activity in the induced radioisotopes calculated efficiencies were used to make corrections due to the differences between the solid angle, photon absorption and photon scattering in the point-like calibration sources and the sources distributed in cement. During the interaction between photoneutrons and the cement samples three radioisotopes were induced: 56 Mn, 24 Na, and 28 Al. (Author)

  14. Cultura Política na Antiguidade

    Directory of Open Access Journals (Sweden)

    José Petrúcio Farias Júnior

    2009-06-01

    Full Text Available

    Pretendemos discutir nesse artigo algumas implicações do termo cultura política na Antiguidade, especificamente, na sociedade romana imperial. Dessa forma, acreditamos que as considerações que apresentaremos a seguir contribuam para reflexão da utilização desse termo, produto das investigações contemporâneas, sobre os estudos das sociedades antigas. Para a historiadora Profa. Dra. Margarida Maria de Carvalho, tais reflexões representam ainda uma lacuna na historiografia concernente a essa temática. Isso posto, discorreremos, inicialmente, sobre o conceito de cultura e seus desdobramentos para, em seguida, refletirmos sobre o viés interpretativo que fundamenta estudos históricos que se desenvolvem sob o beneplácito da linha de pesquisa intitulada História e Cultura Política.

  15. NaI Detector Network at Aragats

    International Nuclear Information System (INIS)

    Avakyan, Karen; Arakelyan, Karen; Chilingarian, Ashot; Daryan, Ara; Kozliner, Lev; Mailyan, Bagrat; Hovsepyan, Gagik; Pokhsraryan, David; Sargsyan, David

    2013-01-01

    The Aragats Space Environmental Center (ASEC) provides monitoring of different species of secondary cosmic rays and consists of two high altitude research stations on Mt. Aragats in Armenia. Along with solar modulation effects, ASEC detectors register several coherent enhancements associated with thunderstorm activity. The experimental techniques used allowed for the first time to simultaneously measure fluxes of the electrons, muons, gamma rays, and neutrons correlated with thunderstorm activity. Ground-based observations by a complex of surface particle detectors, measuring in systematically and repeatable fashion, gamma quanta, electrons, muons and neutrons from atmospheric sources are necessary for proving the theory of particle acceleration and multiplication during thunderstorms. Energy spectra and correlations between fluxes of different particles, measured on Earth's surface address the important issues of research of the solar modulation effects and the atmospheric high-energy phenomena. In May 26 2011, launched 5 NaI(Tl) (thallium-doped sodium iodide) scintillation detectors and 1 plastic one in the new ASEC laboratory on Aragats to detect low energy gamma rays from the thunderclouds and short particle bursts. Including NaI(Tl) detectors in ASEC detectors system is of great importance for investigation thunderstorm phenomena because NaI(Tl) detectors have high efficiency of gamma ray detecting in comparison with plastic ones.

  16. NA64 Search for Dark Photons

    CERN Document Server

    Shiakas, Christos

    2017-01-01

    The NA64 experiment, known as P348 before official approval, was proposed to the CERN SPSC on January 2014 with main goal the search for the following decay modes A′ → invisible A′ → e−e+ (1) In March 2016 P348 was granted approval by the CERN Research Board and received the title NA64. Since having been promoted, the experiment has been conducting the searches the searches for the processes mentioned above at the CERN SPS. NA64 is a fixed target experiment which utilizes the active beam dump. The detection of rare processes is based on the missing energy techniques. Such techniques are used for particles whose interaction with the detector is very small, so that they escape the detection and carry away some energy. A significant missing energy in the experiment means that such particles are produced. The method of the search for the A′ → invisible decay is as follows. If the A′ exists it could be produced via the kinetic mixing with bremsstrahlung photons in the reaction of high-energy elec...

  17. Experimental Study of Na based Titanium Nanofluid-Water Reaction

    Energy Technology Data Exchange (ETDEWEB)

    Park, Gunyeop; Kim, Soo Jae; Baek, Jehyun; Kim, Hyun Soo; Oh, Sun Ryung; Park, Hyun Sun; Kim, Moo Hwan [POSTECH, Pohang (Korea, Republic of)

    2015-10-15

    In KALIMER-600, a sodium-cooled fast reactor designed by KAERI, thermal energy is transported from high-temperature liquid Na (526 .deg. C at 0.1 MPa) to low temperature water (230 .deg. C at - 19.5 MPa) through a heat exchanger. If any leakage or rupture occurs during the operation of this heat exchanger, highly pressurized liquid water can penetrate into the liquid Na channels; this contact should instantly cause SWR. As reaction continues, liquid water is soon vaporized by pressure drop and huge amount of reaction heat. This generated water vapor expands large reaction area and increases sodium-water vapor reaction process. Therefore, the rapid generation of reaction product (like H{sub 2}) and water vapor increases the system pressure that can cause the system failure in SFR. To reduce this strong chemical reaction phenomena between Na and water, some we have focused on suppressing the chemical reactivity of liquid Na by dispersing nanoparticles (NPs). For the real application of NaTiNF, the pressure change induced by NaTiNF-water reaction is compared with Na-water reaction in the present study. NaTiNF contains 100nm of Ti NPs at 0.2 vol. %. The reaction rate of NaTiNF-water reaction is also investigated as reaction temperature increases. Sodium-water vapor reaction (SVR) will occur when an SWR accident occurs in SFR. In this manner, NaTiNF-water vapor reaction is experimentally performed for ensuring the suppression of chemical reactivity of NaTiNF in contact with water vapor. In the basic step for reducing risk of an SWR in SFR, we have experimentally verified the suppressed chemical reactivity of liquid sodium using Ti NPs through SWR and SVR experiments. In SWR, Na based titanium nanofluid (NaTiNF) shows lower pressure change than Na. As T{sub R} increases, P{sub max} in Na-water reaction increases while NaTiNF does not. The reaction rate of NaTiNF shows twice slower than that of Na. In SVR, NaTiNF shows slower temperature increase than Na. The distinct

  18. Route, mechanism, and implications of proton import during Na+/K+ exchange by native Na+/K+-ATPase pumps

    Science.gov (United States)

    Vedovato, Natascia

    2014-01-01

    A single Na+/K+-ATPase pumps three Na+ outwards and two K+ inwards by alternately exposing ion-binding sites to opposite sides of the membrane in a conformational sequence coupled to pump autophosphorylation from ATP and auto-dephosphorylation. The larger flow of Na+ than K+ generates outward current across the cell membrane. Less well understood is the ability of Na+/K+ pumps to generate an inward current of protons. Originally noted in pumps deprived of external K+ and Na+ ions, as inward current at negative membrane potentials that becomes amplified when external pH is lowered, this proton current is generally viewed as an artifact of those unnatural conditions. We demonstrate here that this inward current also flows at physiological K+ and Na+ concentrations. We show that protons exploit ready reversibility of conformational changes associated with extracellular Na+ release from phosphorylated Na+/K+ pumps. Reversal of a subset of these transitions allows an extracellular proton to bind an acidic side chain and to be subsequently released to the cytoplasm. This back-step of phosphorylated Na+/K+ pumps that enables proton import is not required for completion of the 3 Na+/2 K+ transport cycle. However, the back-step occurs readily during Na+/K+ transport when external K+ ion binding and occlusion are delayed, and it occurs more frequently when lowered extracellular pH raises the probability of protonation of the externally accessible carboxylate side chain. The proton route passes through the Na+-selective binding site III and is distinct from the principal pathway traversed by the majority of transported Na+ and K+ ions that passes through binding site II. The inferred occurrence of Na+/K+ exchange and H+ import during the same conformational cycle of a single molecule identifies the Na+/K+ pump as a hybrid transporter. Whether Na+/K+ pump–mediated proton inflow may have any physiological or pathophysiological significance remains to be clarified. PMID

  19. Route, mechanism, and implications of proton import during Na+/K+ exchange by native Na+/K+-ATPase pumps.

    Science.gov (United States)

    Vedovato, Natascia; Gadsby, David C

    2014-04-01

    A single Na(+)/K(+)-ATPase pumps three Na(+) outwards and two K(+) inwards by alternately exposing ion-binding sites to opposite sides of the membrane in a conformational sequence coupled to pump autophosphorylation from ATP and auto-dephosphorylation. The larger flow of Na(+) than K(+) generates outward current across the cell membrane. Less well understood is the ability of Na(+)/K(+) pumps to generate an inward current of protons. Originally noted in pumps deprived of external K(+) and Na(+) ions, as inward current at negative membrane potentials that becomes amplified when external pH is lowered, this proton current is generally viewed as an artifact of those unnatural conditions. We demonstrate here that this inward current also flows at physiological K(+) and Na(+) concentrations. We show that protons exploit ready reversibility of conformational changes associated with extracellular Na(+) release from phosphorylated Na(+)/K(+) pumps. Reversal of a subset of these transitions allows an extracellular proton to bind an acidic side chain and to be subsequently released to the cytoplasm. This back-step of phosphorylated Na(+)/K(+) pumps that enables proton import is not required for completion of the 3 Na(+)/2 K(+) transport cycle. However, the back-step occurs readily during Na(+)/K(+) transport when external K(+) ion binding and occlusion are delayed, and it occurs more frequently when lowered extracellular pH raises the probability of protonation of the externally accessible carboxylate side chain. The proton route passes through the Na(+)-selective binding site III and is distinct from the principal pathway traversed by the majority of transported Na(+) and K(+) ions that passes through binding site II. The inferred occurrence of Na(+)/K(+) exchange and H(+) import during the same conformational cycle of a single molecule identifies the Na(+)/K(+) pump as a hybrid transporter. Whether Na(+)/K(+) pump-mediated proton inflow may have any physiological or

  20. Growth mechanism of NaClO 3 and NaBrO 3 crystals from aqueous ...

    Indian Academy of Sciences (India)

    A study of growth rates of NaClO3 and NaBrO3 has been carried out using a small growth cell by in situ observation. Normal growth rates of {100} faces of NaClO3 and {111} faces of NaBrO3 along ⟨ 110 ⟩ direction are measured under relatively high supersaturation ranging from 3–8%. In the initial stages of growth, {100}, ...

  1. Plant Defensins NaD1 and NaD2 Induce Different Stress Response Pathways in Fungi

    Directory of Open Access Journals (Sweden)

    Peter M. Dracatos

    2016-09-01

    Full Text Available Nicotiana alata defensins 1 and 2 (NaD1 and NaD2 are plant defensins from the ornamental tobacco that have antifungal activity against a variety of fungal pathogens. Some plant defensins interact with fungal cell wall O-glycosylated proteins. Therefore, we investigated if this was the case for NaD1 and NaD2, by assessing the sensitivity of the three Aspergillus nidulans (An O-mannosyltransferase (pmt knockout (KO mutants (An∆pmtA, An∆pmtB, and An∆pmtC. An∆pmtA was resistant to both defensins, while An∆pmtC was resistant to NaD2 only, suggesting NaD1 and NaD2 are unlikely to have a general interaction with O-linked side chains. Further evidence of this difference in the antifungal mechanism was provided by the dissimilarity of the NaD1 and NaD2 sensitivities of the Fusarium oxysporum f. sp. lycopersici (Fol signalling knockout mutants from the cell wall integrity (CWI and high osmolarity glycerol (HOG mitogen-activated protein kinase (MAPK pathways. HOG pathway mutants were sensitive to both NaD1 and NaD2, while CWI pathway mutants only displayed sensitivity to NaD2.

  2. Response of saliva Na/K ratio to changing Na supply of lactating cows under tropical conditions

    NARCIS (Netherlands)

    Thiangtum, Wandee; Schonewille, J Thomas; Verstegen, Martin Wa; Arsawakulsudhi, Supot; Rukkwamsuk, Theera; Hendriks, Wouter H

    BACKGROUND: Factorial determination of the sodium (Na) requirement of heat-stressed lactating cows is hindered by accurate estimates of the Na losses through sweat. Direct studies, therefore, may be needed requiring information on the time course of healthy animals to become Na depleted and the

  3. Response of saliva Na/K ratio to changing Na supply of lactating cows under tropical conditions

    NARCIS (Netherlands)

    Thiangtum, Wandee; Schonewille, Thomas J.; Verstegen, Martin W.A.; Arsawakulsudhi, Supot; Rukkwamsuk, Theera; Hendriks, Wouter H.

    2017-01-01

    BACKGROUND: Factorial determination of the sodium (Na) requirement of heat-stressed lactating cows is hindered by accurate estimates of the Na losses through sweat. Direct studies, therefore, may be needed requiring information on the time course of healthy animals to become Na depleted and the

  4. Polarization and collision velocity dependence of associative ionization in cold Na (3p)-Na(3p) collisions

    NARCIS (Netherlands)

    Meijer, H.A.J.

    1990-01-01

    We studied the polarization dependence of the associative ionization (AI) process Na(3p) + Na(3p) → Na2+ at collision velocities between 100 and 700 m/s (5 and 200 K), using linearly and circularly polarized light for the excitation. We found that the polarization dependence varies strongly in the

  5. Reactions of metal oxides with molten NaPO3 + NaCl mixtures

    International Nuclear Information System (INIS)

    Kovarskaya, E.N.; Mityakhina, V.S.; Rodionov, Yu.I.; Silin, M.Yu.

    1988-01-01

    We consider the dissolution mechanism for iron (III), europium(III), and tin(IV) oxides in molten NaPO 3 + NaCl that are responsible for the peak solubilities. We chose Fe 2 O 3 as the basic material since this occurs in large amounts around damaged metal structures in rock salt mines in a proposed zone for storing vitrified radioactive wastes. Solubility measurement and paper chromatography show that Fe 2 O 3 dissolves in molten NaPO 3 + NaCl in air by reaction with the solvent to give double iron and sodium diphosphates and monophosphates in accordance with the initial solution-in-the-melt composition, the degree of equilibration, and the temperature. The elevated solubilities for initial NaCl contents close to 30 mole % are due to sodium triphosphates and tricyclophosphates present in these melts. Moessbauer spectroscopy confirms that double iron, europium and tin diphosphates and monophosphates containing sodium occur in these chloride-polyphosphate melts

  6. MOBILNO POSLOVANJE NA PRIMERU UPORABE MICROSOFT DYNAMICS CRM

    OpenAIRE

    Duh, Tamara

    2016-01-01

    Hitro razvijajoči se svet nas spodbuja k hitremu reagiranju na novosti, ki se pojavljajo na trgu. Prav zaradi tega je danes zelo pomembno upravljati z mobilnimi napravami, da se lahko hitro in brez težav soočimo z morebitnimi težavami oz. zagatami. Prav iz tega razloga je mobilno poslovanje ena izmed inovativnih rešitev, ki ljudem omogoča seznanjenost z informacijami na vsakem koraku in omogoča hiter odziv na spremembe. Prav ta rešitev omogoča podjetjem, da so konkurenčna in hkrati lahko hitr...

  7. Predstave o seksu u filmovima na temu postapokalipse

    Directory of Open Access Journals (Sweden)

    Ana Banić-Grubišić

    2016-03-01

    Full Text Available Rad se bavi načinima predstavljanja seksualnih odnosa u filmovima na temu postapokalipse. Razmatraju se različiti oblici/vrste seksualnih veza, koje se javljaju u postkataklizmičnom okruženju, u odnosu na dva tipa zajednica/društava koja nastaju nakon kraja sveta. Ti filmovi pokazuju koliko je ideja o nagonskoj, prirodnoj, biološkoj seksualnosti raširena u popularnoj imaginaciji – seks je u postapokalipsi predstavljen kao pokretačka sila, na isti način kao što je to i glad.

  8. Usando a antimatéria na medicina moderna

    OpenAIRE

    Machado,A.C.B.; Pleitez,V.; Tijero,M.C.

    2006-01-01

    Neste artigo, fazemos uma breve exposição de como um dos conceitos fundamentais da física moderna, a existência de antimatéria, tem aplicação na medicina, na chamada tomografia por emissão de pósitrons (PET na sigla em inglês). Ela consiste na produção de imagens tomográficas digitais do organismo que são obtidas pela detecção da radiação produzida na aniquilação do pósitron com o elétron.

  9. Imenovanje jednonitnih homopolimera i kopolimera na osnovi podrijetla (I. dio

    Directory of Open Access Journals (Sweden)

    Vida Jarm

    2018-04-01

    Full Text Available Prethodne IUPAC-ove preporuke imenovanja (nomenklature jednonitnih polimera na osnovi podrijetla (NOP odnosile su se uglavnom na kopolimere, nelinearne polimere, združene polimere i generičke polimere. Pravila navedena u ovim preporukama omogućuju jasnije i preciznije imenovanje polimera na osnovi podrijetla, kako homopolimera tako i kopolimera. Prikazani sveobuhvatni sustav imenovanja polimera na osnovi podrijetla prihvatljiva je alternativa sustavu imenovanja polimera na osnovi strukture. Zbog raširene i česte uporabe dodatno su opisane i preporuke za uporabu uvriježenih imena polimera.

  10. Novel regulation of cardiac Na pump via phospholemman.

    Science.gov (United States)

    Pavlovic, Davor; Fuller, William; Shattock, Michael J

    2013-08-01

    As the only quantitatively significant Na efflux pathway from cardiac cells, the Na/K ATPase (Na pump) is the primary regulator of intracellular Na. The transmembrane Na gradient it establishes is essential for normal electrical excitability, numerous coupled-transport processes and, as the driving force for Na/Ca exchange, thus setting cardiac Ca load and contractility. As Na influx varies with electrical excitation, heart rate and pathology, the dynamic regulation of Na efflux is essential. It is now widely recognized that phospholemman, a 72 amino acid accessory protein which forms part of the Na pump complex, is the key nexus linking cellular signaling to pump regulation. Phospholemman is the target of a variety of post-translational modifications (including phosphorylation, palmitoylation and glutathionation) and these can dynamically alter the activity of the Na pump. This review summarizes our current understanding of the multiple regulatory mechanisms that converge on phospholemman and govern NA pump activity in the heart. The corrected Fig. 4 is reproduced below. The publisher would like to apologize for any inconvenience caused. [corrected]. Copyright © 2013. Published by Elsevier Ltd.

  11. Synthesis of zeolites Na-A and Na-X from tablet compressed and calcinated coal fly ash

    Science.gov (United States)

    Hu, Tao; Gao, Wenyan; Liu, Xin; Zhang, Yifu; Meng, Changgong

    2017-10-01

    Zeolites Na-A and Na-X are important synthetic zeolites widely used for separation and adsorption in industry. It is of great significance to develop energy-efficient routines that can synthesize zeolites Na-A and Na-X from low-cost raw materials. Coal fly ash (CFA) is the major residue from the combustion of coal and biomass containing more than 85% SiO2 and Al2O3, which can readily replace the conventionally used sodium silicate and aluminate for zeolite synthesis. We used Na2CO3 to replace the expensive NaOH used for the calcination of CFA and showed that tablet compression can enhance the contact with Na2CO3 for the activation of CFA through calcination for the synthesis of zeolites Na-A and Na-X under mild conditions. We optimized the control variables for zeolite synthesis and showed that phase-pure zeolite Na-A can be synthesized with CFA at reactant molar ratio, hydrothermal reaction temperature and reaction time of 1.3Na2O: 0.6Al2O3: 1SiO2: 38H2O at 80°C for 6 h, respectively, while phase-pure zeolite Na-X can be synthesized at 2.2Na2O: 0.2Al2O3: 1SiO2: 88H2O at 100°C for 8 h, respectively. The composition, morphology, specific surface area, vibration spectrum and thermogravimetry of synthesized Na-A and Na-X were further characterized.

  12. Synthesis of Na-A and/or Na-X zeolite/porous carbon composites from carbonized rice husk

    International Nuclear Information System (INIS)

    Katsuki, Hiroaki; Komarneni, Sridhar

    2009-01-01

    Na-A and/or Na-X zeolite/porous carbon composites were prepared under hydrothermal conditions by NaOH dissolution of silica first from carbonized rice husk followed by addition of NaAlO 2 and in situ crystallization of zeolites i.e., using a two-step process. When a one-step process was used, both Na-A and Na-X zeolites crystallized on the surface of carbon. Na-A or Na-X zeolite crystals were prepared on the porous carbonized rice husk at 90 deg. C for 2-6 h by changing the SiO 2 /Al 2 O 3 , H 2 O/Na 2 O and Na 2 O/SiO 2 molar ratios of precursors in the two-step process. The surface area and NH 4 + -cation exchange capacity (CEC) of Na-A zeolite/porous carbon were found to be 171 m 2 /g and 506 meq/100 g, respectively, while those of Na-X zeolite/porous carbon composites were 676 m 2 /g and 317 meq/100 g, respectively. Na-A and Na-X zeolites are well-known microporous and hydrophilic materials while carbonized rice husk was found to be mesoporous (pores of ∼3.9 nm) and hydrophobic. These hybrid microporous-mesoporous and hydrophilic-hydrophobic composites are expected to be useful for decontamination of metal cations as well as organic contaminants simultaneously. - Graphical Abstract: Novel Na-X zeolite/porous carbon composite.

  13. Recovery of the heavy elements by NaY AND NaZSM-5 sorbant materials

    International Nuclear Information System (INIS)

    Nibou, D.; Lebail, S.

    1997-04-01

    Porous sorbants as zeolites have a several applications in differents fiels: industrial gas purification, catalysis, transformation hydrocarbures prosesses and exchange ions. The hiogh capacity to exchange their cations with those of aqueous solutions was known (1). Since the accession of synthetic zeolites, these silicates have invaded the market and the firstindustrial applications were in exchange field. Studies at Battelle Northwest in Rchland, Washington have shown that zeolites may be used in treatment of radioactive wastes (2). The used method for storing the isotopes is based on selective removal by ion exchange. Clinoptilolite, zeolite (modernite), NaA, and AW-500 have been used. In this context, the present work deals with the recovery of heavy metals like lead and uranium using some microporous materials. The obtained results show that NaY faujasite and NaZSM-5 of the FAU- and MFI-type structure respectively are very effective in removing these elements from waste water

  14. Reaction of metal oxides with molten mixtures NaPO3+NaCl

    International Nuclear Information System (INIS)

    Kovarskaya, E.N.; Mityakhina, V.S.; Rodionov, Yu.I.; Silin, M.Yu.

    1988-01-01

    By methods of solubility determination and paper chromatography it is shown, that Fe 2 O 3 solution in NaPO 3 +NaCl melts in the air relizes due to its chemical interaction with solvent resulting in formation of iron and sodium binary di- and monophosphates depending on melt-solvent initial composition, its attainment of equilibrium state and experiment temperature. It is established, that oxides increased solubility in melts with NaCl initial content ∼30 mol.% is specified by sodium tri- and tricyclophosphates presence in the melts. On this basis of NGR-spectroscopy data the presence of iron, europium, tin and sodium binary di- and monophosphates in some chloride-polyphosphate melts is confirmed

  15. NA48 experiment : view along the NA48 beamline with the detector in the distance.

    CERN Multimedia

    Hans Taureg

    1996-01-01

    Photo 02: Side view of the NA48 experiment showing the LKR calorimeter cryostat No one is sure why the Universe wound up the way it has: all matter and no antimatter. According to prevailing theories, the early universe had equal amounts of matter and antimatter. To see what might be missing from the theories, physicists search for the rare cases in which matter and antimatter behave differently. One such imbalance, called direct CP violation, showed up in the NA 31 experiment at CERN. The results from this experiment, first presented in 1993, showed that when K mesons and their antimatter cousins decay, they show a slight preference for matter over antimatter. Later experiments with neutral K mesons, including NA48 at CERN and KTeV at Fermilab in the United States, showed direct CP violation is real.

  16. Erythrocyte Na+/K+ ATPase activity measured with sup 23 Na NMR

    Energy Technology Data Exchange (ETDEWEB)

    Ouwerkerk, R.; van Echteld, C.J.; Staal, G.E.; Rijksen, G. (University Hospital, Utrecht (Netherland))

    1989-11-01

    A {sup 23}Na NMR assay for measurement of erythrocyte Na+/K+ ATPase activity is presented. Using the nonpermeant shift reagent dysprosium tripolyphosphate the signals of intra- and extracellular sodium are separated, enabling measurement of sodium fluxes nondestructively, without the need to physically separate the cells from their environment. By increasing membrane permeability with nystatin we have shown that the assay allows the detection of differences in membrane permeability. With low doses of nystatin the ouabain-sensitive sodium flux increased more than twofold. With high doses of nystatin the Na+/K+ pump could not prevent an almost total equilibration of intra- and extracellular sodium. All sodium that entered the cells remained NMR visible, proving that sodium influx can be measured quantitatively. {sup 31}P NMR spectra taken before and after the assay revealed a slight acidification of the cells and no significant change in ATP concentration. No evidence of Dy3+ entering the cell was observed.

  17. Energy levels of the single excited states in NaI and Na-like ions

    International Nuclear Information System (INIS)

    El-Sherbini, T.M.; Wahby, A.S.

    1987-08-01

    Energy levels of the single excited 1s 2 2s 2 2p 6 ns( 2 S), 1s 2 2s 2 2p 6 mp( 2 P), 1s 2 2s 2 2p 6 md( 2 D) and 1s 2 2s 2 2p 6 nf( 2 F); n=4-7, m=3-6 states for NaI and Na-like ions are calculated using the one configuration Hartree-Fock method. Good agreement is obtained between our results for the higher members of the NaI sequence and previous data from photo-absorption and beam foil experiments. (author). 11 refs, 3 figs, 9 tabs

  18. Na+-K+ pump in chronic renal failure

    International Nuclear Information System (INIS)

    Deepak, K.; Kahn, T.

    1987-01-01

    This review summarizes the evidence for the defect in Na + -K + pump in chronic renal failure, considers the role of various factors in causing this defect, and discusses the clinical implications thereof. Intracellular Na is elevated in erythrocytes, leukocytes, and muscle cells from some patients with chronic renal failure (CRF). Recent evidence suggest that this elevation of cell Na may be, in large part, a consequence of decreased number of Na + -K + pump units per cell. Maintenance dialysis over a period of weeks ameliorates the defect in intracellular Na + , and this improvement is contemporaneous with an increase in the number of Na + -K + pump sites per cell. In erythrocytes with normal cell Na + , acute hemodialysis increases the rate of 22 Na + and 42 K + transport. Many factors such as the presence of retained toxic metabolite or circulating inhibitor in the uremic plasma, or biochemical changes produced by acute hemodialysis, may explain this finding. In cells with high cell Na + , the pump-mediated 42 K + transport is normalized at the expense of a raised cell Na + . The decreased muscle membrane potential in uremic subjects has been attributed to a decreased activity of Na + -K + pump. The authors discuss the role of hormonal abnormalities and circulating inhibitors, which may cause an acute inhibition of the pump and of other factors such as K + depletion, which may cause more chronic alterations. The implications of alteration of Na + and K + pump transport and raised cell Na + on other non-pump-mediated transport pathways are discussed. Raised cell Na + may be a marker for the adequacy of maintenance dialysis in patients with end-stage renal failure

  19. Izdelovalci glasbil na Slovenskem 1606–1918

    Directory of Open Access Journals (Sweden)

    Darja Koter

    2003-12-01

    Full Text Available Proučevanje zgodovine izdelovanja inštrumentov in posameznih izdelovalcev na Slovenskem nima dolge tradicije. Na ta del glasbene preteklosti je strokovno in drugo javnost prvi opozoril Josip Mantuani ob 60-letnici ljubljanske Glasbene matice leta 1932, ki je ob tej priložnosti v Narodnem domu v Ljubljani organizirala veliko razstavo Razvoj glasbe pri Slovencih, kjer so bili z izdelki predstavljeni tudi nekateri starejši in sodobni domači izdelovalci inštrumentov. Med najmanj razvitimi segmenti muzikologije na Slovenskem sta organologija glasbenih inštrumentov in zgodovina izdelovanja glasbil. Večje strokovne pozornosti so bile deležne predvsem orgle in orglarji. Orglarstvo in posamezne mojstre so od sedemdesetih let naprej proučevali Ladislav Šaban, Milko Bizjak in Edo Škulj, v zadnjem desetletju pa se stopnjuje zanimanje še za izdelovalce drugih inštrumentov, ki so v preteklih stoletjih delovali na ozemlju današnje Slovenije. Rezultati posameznih študij so objavljeni v različnih publikacijah, revijah, zbornikih in leksikonih, nekaj podatkov o izdelovalcih pa najdemo tudi v tuji literaturi. Da bi bilo poznavanje zgodovine izdelovanja glasbil in posameznih mojstrov bolj pregledno in dostopnejše, je nujno, da objavljene dosežke strnemo v obliki gesel z vsemi najbolj vitalnimi podatki, s čimer bodo imeli uporabniki boljši dostop do informacij. Pri oblikovanju gesel je bila upoštevana metodologija, ki se je uveljavila v nemški in angleški leksikografski literaturi. Imena izdelovalcev so zapisana v izvirni obliki, ponekod pa so dodane še različice priimkov in imen, ki jih najdemo v primarnih virih. Pri rojstnih podatkih so navedene letnice rojstva in smrti ter natančni datumi, kadar so znani. V primerih, kjer čas rojstva ni ugotovljen, so pomembne letnice delovanja posameznika. Primer: CAJHEN, (Zeichen, Martin (1855–1863. Pri poklicu je mogočih več navedb, npr. izdelovalec orgel, organist, trgovec z glasbili ... Kadar

  20. A metodologia de projecto na aprendizagem da biodiversidade e geodiversidade na praia da concha

    OpenAIRE

    Rosa, Marina Maria Filipe

    2012-01-01

    Dissertação de mestrado em Biologia e de Geologia, apresentada ao Departamento de Ciências da Terra e ao Departamento de Ciências da Vida Este trabalho consistiu na implementação e avaliação da metodologia de projeto no estudo da Biodiversidade e Geodiversidade na Praia da Concha, Portugal Central, dando ênfase ao trabalho prático, através de uma aula de campo e de aulas laboratoriais. O trabalho foi realizado numa escola da Marinha Grande, com 11 alunos do 10º ano de escolaridade. Sendo a...

  1. Velocity distribution and dimer formation in a Na/Na2 beam

    International Nuclear Information System (INIS)

    Bergmann, K.; Hefter, U.; Hering, P.

    1977-01-01

    Using the TOF via optical pumping method and the Doppler-shifted laser induced emission described previously, the authors have measured the parallel and perpendicular velocity distribution respectively for Na atoms and Na 2 molecules in a variety of individual quantum states. In addition they monitored the flux of molecules in specific states while changing the stagnation pressure. In all cases a significant dependence on the internal energy of the molecules was found. The goal of these experiments is to improve understanding of the beam dynamics and the dimer formation process. (Auth.)

  2. OGLAŠEVANJE NA SOCIALNEM OMREŽJU FACEBOOK, NA PRIMERU SPLETICNA.SI

    OpenAIRE

    Reisman, Nina

    2011-01-01

    Internet je od svojega razvoja dolgo časa obstajal kot prostor za enostransko komunikacijo. Isto se je dogajalo na televiziji, radiu in časopisih, kjer je javnost sprejemala informacije, ki jih je nekdo pripravil. Tradicionalni mediji so hitro doumeli, da takšna vrsta komunikacije ni naravna in ne predstavlja najboljšega ohranjanja gledalcev in poslušalcev. Začela se je uporabljati dvosmerna komunikacija. Trenutno v svetu najbolje poznan primer dvosmerne komunikacije je socialno omrežje F...

  3. Design and implementation of the NaI(Tl)/CsI(Na) detectors output signal generator

    International Nuclear Information System (INIS)

    Zhou Xu; Liu Congzhan; Zhao Jianling

    2014-01-01

    We designed and implemented a signal generator that can simulate the output of the NaI(Tl)/CsI(Na) detectors' pre-amplifier onboard the Hard X-ray Modulation Telescope (HXMT). Using the development of the FPGA (Field Programmable Gate Array) with VHDL language and adding a random constituent, we have finally produced the double exponential random pulse signal generator. The statistical distribution of the signal amplitude is programmable. The occurrence time intervals of the adjacent signals contain negative exponential distribution statistically. (authors)

  4. Design and implementation of the NaI(Tl)/CsI(Na) detectors output signal generator

    Science.gov (United States)

    Zhou, Xu; Liu, Cong-Zhan; Zhao, Jian-Ling; Zhang, Fei; Zhang, Yi-Fei; Li, Zheng-Wei; Zhang, Shuo; Li, Xu-Fang; Lu, Xue-Feng; Xu, Zhen-Ling; Lu, Fang-Jun

    2014-02-01

    We designed and implemented a signal generator that can simulate the output of the NaI(Tl)/CsI(Na) detectors' pre-amplifier onboard the Hard X-ray Modulation Telescope (HXMT). Using the development of the FPGA (Field Programmable Gate Array) with VHDL language and adding a random constituent, we have finally produced the double exponential random pulse signal generator. The statistical distribution of the signal amplitude is programmable. The occurrence time intervals of the adjacent signals contain negative exponential distribution statistically.

  5. Subnitride chemistry: A first-principles study of the NaBa3N, Na5Ba3N, and Na16Ba6N phases

    International Nuclear Information System (INIS)

    Oliva, Josep M.

    2005-01-01

    An ab initio study on the electronic structure of the subnitrides NaBa 3 N, Na 5 Ba 3 N, and Na 16 Ba 6 N is performed for the first time. The NaBa 3 N and Na 5 Ba 3 N phases consist of infinite 1 ∞ [NBa 6/2 ] strands composed of face-sharing NBa 6 octahedra surrounded by a 'sea' of sodium atoms. The Na 16 Ba 6 N phase consist of discrete [NBa 6 ] octahedra arranged in a body-cubic fashion, surrounded by a 'sea' of sodium atoms. Our calculations suggest that the title subnitrides are metals. Analysis of the electronic structure shows partial interaction of N(2s) with Ba(5p) electrons in the lower energy region for NaBa 3 N and Na 5 Ba 3 N. However, no dispersion is observed for the N(2s) and Ba(5p) bands in the cubic phase Na 16 Ba 6 N. The metallic band below the Fermi level shows a strong mixing of N(2p), Ba(6s), Ba(5d), Ba(6p), Na(3s) and Na(3p) orbitals. The metallic character in these nitrides stems from delocalized electrons corresponding to hybridized 5d l 6s m 6p n barium orbitals which interact with hybridized 3s n 3p m sodium orbitals. Analysis of the electron density and electronic structure in these nitrides shows two different regions: a metallic matrix corresponding to the sodium atoms and the regions around them and heteropolar bonding between nitrogen and barium within the infinite 1 ∞ [NBa 6/2 ] strands of the NaBa 3 N and Na 5 Ba 3 N phases, and within the isolated [NBa 6 ] octahedra of the Na 16 Ba 6 N phase. The nitrogen atoms inside the strands and octahedra are negatively charged, the anionic character of nitrogens being larger in the isolated octahedra of the cubic phase Na 16 Ba 6 N, due to the lack of electron delocalization along one direction as opposed to the other phases. The sodium and barium atoms appear to be slightly negatively and positively charged, the latter to a larger extent. From the computed Ba-N overlap populations as well as the analysis of the contour maps of differences between total density and superposition of

  6. NaI(Tl) response functions

    Energy Technology Data Exchange (ETDEWEB)

    Vega C, H. R.; Ortiz R, J. M. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas, Zac. (Mexico); Benites R, J. L. [Centro Estatal de Cancerologia de Nayarit, Calz. de la Cruz 118 Sur, Tepic, Nayarit (Mexico); De Leon M, H. A., E-mail: fermineutron@yahoo.com.mx [Instituto Tecnologico de Aguascalientes, Av. Adolfo Lopez Mateos 1801 Ote., 20155 Aguascalientes, Ags. (Mexico)

    2015-09-15

    The response functions of a NaI(Tl) detector have been estimated using Monte Carlo methods. Response functions were calculated for monoenergetic photon sources (0.05 to 3 MeV). Responses were calculated for point-like sources and for sources distributed in Portland cement cylinders. The responses were used to calculate the efficiency functions in term of photon energy. Commonly, sources used for calibration are point-like, and eventually sources to be measured have different features. In order to use the calibrated sources corrections due to solid angle, self-absorption and scattering, must be carried out. However, some of these corrections are not easy to perform. In this work, the calculated responses were used to estimate the detector efficiency of point-like sources, and sources distributed in Portland type cement. Samples of Portland paste were prepared and were exposed to photoneutrons produced by a 15 MV linac. Some of the elements in the cement were activated producing γ-emitting radionuclides that were measured with a NaI(Tl) gamma-ray spectrometer, that was calibrated with point-like sources. In order to determine the specific activity in the induced radioisotopes calculated efficiencies were used to make corrections due to the differences between the solid angle, photon absorption and photon scattering in the point-like calibration sources and the sources distributed in cement. During the interaction between photoneutrons and the cement samples three radioisotopes were induced: {sup 56}Mn, {sup 24}Na, and {sup 28}Al. (Author)

  7. Teratological studies of DTPA-CaNa3, DTPA-ZnNa3 and quinamic acid in mice

    International Nuclear Information System (INIS)

    Luo Meichu; Ruan Tianming; Tong Shungao

    1989-01-01

    DTPA-CaNa 3 , DTPA-ZnNa 3 and quinamic acid are effective chelating agents for removing actinide elements from the body. In this experiment, different doses of DTPA-CaNa 3 , DTPA-ZnNa 3 and quinamic acid were given to mice on gestation days 6-10. Eight groups of mice received 0.8 and 2.0 mM/kg of DTPA-CaNa 3 , 3.8, 7.6, and 11.4 mM/kg of DTPA-ZnNa 3 and 0.42, 2.1, and 4.2 mM/kg of quinamic acid. Hypetonic saline and isotonic saline were given to two control groups. DTPA-CaNa 3 and quinamidic acid were found to be much more toxic to fetus of mice than DTPA-ZnNa 3 . When the doses of DTPA-CaMa 3 and quinamidic acid were 20 times higher than the human dose, the number of resorbed fetus was increased and the number and weight of live fetus were reduced. The result of injection with 7.6 mM/kg (200 times of human dose)DTPA-ZnNa 3 and that of injection with isotonic saline are the same. Therefore, we suggest that the DTPA-CaNa 3 and quinamidic acid should not be given to pregnant woman, if chelation therapy is needed, while the much safer DTPA-ZnNa 3 could be used

  8. Results on leptonic probes from NA50

    CERN Document Server

    Alessandro, B; Arnaldi, R; Atayan, M; Baglin, C; Baldit, A; Bedjidian, Marc; Beolè, S; Boldea, V; Bordalo, P; Borenstein, S R; Borges, G; Bussière, A; Capelli, L; Castanier, C; Castor, J I; Chaurand, B; Cheynis, B; Chiavassa, E; Cicalò, C; Claudino, T; Comets, M P; Constantinescu, S; Cortese, P; Cruz, J; De Falco, A; De Marco, N; Dellacasa, G; Devaux, A; Dita, S; Drapier, O; Espagnon, B; Fargeix, J; Force, P; Gallio, M; Gavrilov, Yu K; Gerschel, C; Giubellino, P; Golubeva, M B; Gonin, M; Grigorian, A A; Grigorian, S; Grossiord, J Y; Guber, F F; Guichard, A; Gulkanian, H R; Hakobyan, R S; Haroutunian, R; Idzik, M; Jouan, D; Karavitcheva, T L; Kluberg, L; Kurepin, A B; Le Bornec, Y; Lourenço, C; Macciotta, P; MacCormick, M; Marzari-Chiesa, A; Masera, M; Masoni, A; Monteno, M; Musso, A; Petiau, P; Piccotti, A; Pizzi, J R; Prado da Silva, W L; Prino, F; Puddu, G; Quintans, C; Ramello, L; Ramos, S; Rato-Mendes, P; Riccati, L; Romana, A; Santos, H; Saturnini, P; Scalas, E; Scomparin, E; Serci, S; Shahoyan, R; Sigaudo, F; Sitta, M; Sonderegger, P; Tarrago, X; Topilskaya, N S; Usai, G L; Vercellin, Ermanno; Villatte, L; Willis, N; Wu, T

    2003-01-01

    The NA50 Collaboration has performed a new measurement of the J/ psi yield in Pb-Pb collisions at 158 GeV/nucleon in improved experimental conditions. Our preliminary analysis of the year 2000 data sample, while confirming the onset of anomalous suppression and the non saturation of the J/ psi /Drell-Yan cross-section ratio, shows that peripheral Pb-Pb interactions follow the normal nuclear absorption pattern, which has in turn been established more precisely thanks to high statistics p-A data. (11 refs).

  9. Disfonia na criança

    OpenAIRE

    Marta, Diana Simões

    2017-01-01

    Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2017 Disfonia é um termo clínico que se refere a todas as alterações e dificuldades na emissão vocal que impedem a produção normal da voz. É um sintoma frequente em idade pediátrica com consequências negativas em vários aspetos da vida da criança. Este artigo tem como objetivo resumir o conhecimento atual sobre a definição, epidemiologia, etiologia, características clínicas, abordag...

  10. Skate na cidade, imagens da cidade

    OpenAIRE

    Machado, Giancarlo Marques Carraro

    2014-01-01

    Apesar da existência de dezenas de pistas de skate na cidade de São Paulo – espaços considerados “próprios” para o skate -, a maioria dos skatistas da modalidade street skate confere maior importância à prática feita nas ruas, onde, para muitos, se “anda de skate de verdade”. A atração que elas exercem é a possibilidade de encontrar diferentes tipos de picos, ou seja, equipamentos urbanos (bancos, corrimãos, escadas, canteiros) obstáculos onde se realizam as manobras. Este artigo busca analis...

  11. The NA62 experiment at CERN

    International Nuclear Information System (INIS)

    Piccini, Mauro

    2016-01-01

    The rare decays K → πvv-bar are excellent processes to make tests of new physics at the highest scale complementary to LHC thanks to their theoretically cleanness. The NA62 experiment at CERN SPS aims to collect of the order of 100 events in two years of data taking for the decay K"+ → π"+vv-bar, keeping the background at the level of 10%. Part of the experimental apparatus has been commissioned during a technical run in 2012. The diverse and innovative experimental techniques will be explained and some preliminary results obtained during the 2014 pilot run will be reviewed

  12. Cerenkov counter for the experiment NA3

    CERN Multimedia

    1978-01-01

    The program of the NA3 experiment included the study of hadronic interactions with a large transverse momentum pT, thus the inclusion in the set-up of three gas threshold Cerenkov counters of large acceptance. The photo shows the downstream part of the second Cerenkov (located at the output of the magnet). The yellow membrane is a temporary protection for the optics (shown in photo 7810540X) to be taken away when fixing this part to the gas tank (entering the magnet and not shown). The photomultipliers all around are heavily shielded.

  13. Na(+),K (+)-ATPase as a docking station: protein-protein complexes of the Na(+),K (+)-ATPase.

    Science.gov (United States)

    Reinhard, Linda; Tidow, Henning; Clausen, Michael J; Nissen, Poul

    2013-01-01

    The Na(+),K(+)-ATPase, or sodium pump, is well known for its role in ion transport across the plasma membrane of animal cells. It carries out the transport of Na(+) ions out of the cell and of K(+) ions into the cell and thus maintains electrolyte and fluid balance. In addition to the fundamental ion-pumping function of the Na(+),K(+)-ATPase, recent work has suggested additional roles for Na(+),K(+)-ATPase in signal transduction and biomembrane structure. Several signaling pathways have been found to involve Na(+),K(+)-ATPase, which serves as a docking station for a fast-growing number of protein interaction partners. In this review, we focus on Na(+),K(+)-ATPase as a signal transducer, but also briefly discuss other Na(+),K(+)-ATPase protein-protein interactions, providing a comprehensive overview of the diverse signaling functions ascribed to this well-known enzyme.

  14. Effect of growth in lithium on ouabain binding, Na-K-ATPase and Na and K transport in hela cells.

    Science.gov (United States)

    Boardman, L J; Hume, S P; Lamb, J F; Polson, J

    1975-01-01

    1. HeLa cells were grown for 24 hr in growth medium in which part of the Na was replaced with Li. Ion contents, cell volumes and numbers, Na-K-ATPase and specific ouabain binding were measured. In some experiments the Na efflux and net Na transport was also measured. 2. Growth in Li caused a rise in the specific ouabain binding and membrane Na-K-ATPase of these cells. The Li concentrations in the cells necessary to produce this effect ranged up to 50 mM. 3. It is suggested that Li, like Na, acts on the genetic material of the cells to cause the production of more Na pumps within the membrane. PMID:124350

  15. The relation between aging, aortic NaF avidity and coronary artery NaF avidity: A NaF PET CT study

    DEFF Research Database (Denmark)

    Blomberg, Björn; Thomassen, Anders; Hildebrandt, Malene

    2013-01-01

    volunteers without traditional cardiovascular risk factors were prospectively assessed by Sodium 18-Fluoride (Na-18F) PET CT imaging. Global aortic uptake of Na-18F was determined by calculating the average aortic blood pool subtracted maximum standardized uptake value (cSUV) [maximum SUVaorta - mean...

  16. Minimizing Load Effects on NA4 Gear Vibration Diagnostic Parameter

    Science.gov (United States)

    Dempsey, Paula J.; Zakrajsek, James J.

    2001-01-01

    NA4 is a vibration diagnostic parameter, developed by researchers at NASA Glenn Research Center, for health monitoring of gears in helicopter transmissions. The NA4 reacts to the onset of gear pitting damage and continues to react to the damage as it spreads. This research also indicates NA4 reacts similarly to load variations. The sensitivity of NA4 to load changes will substantially affect its performance on a helicopter gearbox that experiences continuously changing load throughout its flight regimes. The parameter NA4 has been used to monitor gear fatigue tests at constant load. At constant load, NA4 effectively detects the onset of pitting damage and tracks damage severity. Previous research also shows that NA4 reacts to changes in load applied to the gears in the same way it reacts to the onset of pitting damage. The method used to calculate NA4 was modified to minimize these load effects. The modified NA4 parameter was applied to four sets of experimental data. Results indicate the modified NA4 is no longer sensitive to load changes, but remains sensitive to pitting damage.

  17. Advancement of technology towards developing Na-ion batteries

    Science.gov (United States)

    Jamesh, Mohammed Ibrahim; Prakash, A. S.

    2018-02-01

    The Na-ion-batteries are considered much attention for the next-generation power-sources due to the high abundance of Na resources that lower the cost and become the alternative for the state of the art Li-ion batteries in future. In this review, the recently reported potential cathode and anode candidates for Na-ion-batteries are identified in-light-of-their high-performance for the development of Na-ion-full-cells. Further, the recent-progress on the Na-ion full-cells including the strategies used to improve the high cycling-performance (stable even up-to 50000 cycles), operating voltage (even ≥ 3.7 V), capacity (>350 mAhg-1 even at 1000 mAg-1 (based-on-mass-of-the-anode)), and energy density (even up-to 400 Whkg-1) are reviewed. In addition, Na-ion-batteries with the electrodes containing reduced graphene oxide, and the recent developments on symmetric Na-ion-batteries are discussed. Further, this paper identifies the promising Na-ion-batteries including the strategies used to assemble full-cell using hard-carbon-anodes, Na3V2(PO4)3 cathodes, and other-electrode-materials. Then, comparison between aqueous and non-aqueous Na-ion-batteries in terms of voltage and energy density has been given. Later, various types of electrolytes used for Na-ion-batteries including aqueous, non-aqueous, ionic-liquids and solid-state electrolytes are discussed. Finally, commercial and technological-developments on Na-ion-batteries are provided. The scientific and engineering knowledge gained on Na-ion-batteries afford conceivable development for practical application in near future.

  18. Criptococose pulmonar: aspectos na tomografia computadorizada

    Directory of Open Access Journals (Sweden)

    Silva Ana Carina Gamboa da

    2003-01-01

    Full Text Available A criptococose pulmonar é uma doença causada pelo Criptococcus neoformans, um fungo unimórfico que possui distribuição mundial, existindo na mesma forma tanto no seu habitat natural quanto em animais e humanos. A doença possui apresentações clínica e patológica variáveis e pode manifestar-se tanto em pacientes com a imunidade normal como em imunocomprometidos, que representam a maioria dos casos. Neste trabalho são analisados os aspectos encontrados nas tomografias computadorizadas do tórax de 14 pacientes com criptococose pulmonar confirmada. Os achados mais freqüentes na tomografia do tórax foram as massas e os nódulos pulmonares. Outros aspectos observados foram as áreas de escavação, as consolidações, o espessamento do interstício peribroncovascular e o reticulado difuso. Massa pulmonar foi o achado isolado mais comum (64,2%, seguido dos nódulos isolados ou múltiplos (35,7%. Doença pulmonar difusa foi vista em apenas 14,2% dos casos. Os lobos superiores foram os mais comprometidos, sendo a doença mais comum nas regiões anteriores. A tomografia do tórax permitiu avaliar com precisão o grau de comprometimento do parênquima pulmonar.

  19. Vinhos, Turismo e Pluriatividade na Agricultura

    Directory of Open Access Journals (Sweden)

    Hernanda Tonini

    2013-06-01

    Full Text Available A gastronomia, além de ter importante relação com a economia, é uma forma expressiva da cultura dos indivíduos, desde o tipo de alimentos cultivados até a maneira de seu preparo e consumo. O presente artigo propõe-se a analisar a relação entre o enoturismo – centralizado na existência do vinho enquanto elemento gastronômico – e o fenômeno da pluriatividade na agricultura familiar, vista nos últimos anos como alternativa positiva para sua reprodução econômica e social. O fluxo turístico em regiões vitivinícolas gera novas oportunidades de trabalho e faz com que agricultores e suas famílias dividam a mão de obra agrícola, até então direcionada ao cultivo da uva e outros alimentos para subsistência, com atividades não agrícolas – como o artesanato, o acolhimento de visitantes em pousadas, a atuação em restaurantes, entre outras – como chance de subsistência. Este panorama transforma as realidades do mundo rural, alterando a relação do agricultor com a produção de alimentos e a forma como o mesmo os utiliza, além de reestruturar o ambiente sociocultural no seu entorno.  

  20. The NA60 experiment results and perspectives

    CERN Document Server

    Heuser, J M; Banicz, K; Borer, K; Buytaert, J; Castor, J I; Chaurand, B; Chenn, W; Cheynis, B; Cicalò, C; Colla, A; Cortese, R; David, A; De Falco, A; De Marco, N; Devaux, A; Drees, A; Ducroux, L; Enyo, H; Ferretti, A; Floris, M; Force, P; Grigorian, A A; Grossiord, J Y; Guettet, N; Guichard, A; Gulkanian, H R; Keil, M; Kluberg, L; Li, Z; Lourenço, C; Lozano-Bahilo, J; Manso, F; Masoni, A; Neves, A; Ohnishi, H; Oppedisano, C; Parracho, P; Puddu, G; Radermacher, E; Rosinsky, P; Scomparin, E; Seixas, J; Serci, S; Shahoyan, R; Sonderegger, P; Tieulent, R; Usai, G L; Vardanian, H; Veenhof, R; Wöhri, H K

    2003-01-01

    The NA60 experiment takes place at the SPS at CERN, to study the production of open charm and prompt dimuons in collisions induced by proton and heavy ion beams on nuclear targets. For this task, several novel detector systems were added to the dimuon spectrometer and zero-degree calorimeter, which were previously used in the NA50 experiment. The main upgrade is a new silicon pixel vertex spectrometer. It tracks the charged particles that are produced through the collisions in the target and allows us to match their trajectories and momenta with those of the muons that are measured behind the hadron absorber in the muon spectrometer. Besides improving considerably the dimuon mass resolution, the vertex telescope measures the offset of each muon track with respect to the interaction point. This allows us to select events where charm mesons were produced. We present in this article first results from dimuon data that were acquired in Summer 2002 with a 400 GeV proton beam. A silicon microstrip telescope was use...

  1. The NA62 GigaTracker

    CERN Document Server

    Perrin-Terrin, Mathieu

    2015-01-01

    The GigaTracker is an hybrid silicon pixel detector built for the NA62 experiment aiming at measuring the branching fraction of the ultra-rare kaon decay K + ! p + n ̄ n at the CERN SPS. The detector has to track particles in a beam with a flux reaching 1.3 MHz/mm 2 and provide single-hit timing with 200ps RMS resolution for a total material budget of less than 1.5 X 0 . The tracker comprises three 60.8mm 27mm stations installed in vacuum ( 10$^{-6}$ mbar) and cooled with liquid C 6 F 14 circulating through micro-channels etched inside few hundred of microns thick silicon plates. Each station is composed of a 200 m m thick silicon sensor readout by 2 x 5 cus- tom 100 m m thick ASIC, called TDCPix. Each chip contains 40 x 45 asynchronous pixels, each 300 m m x 300 m m and is instrumented with 100ps bin time-to-digital converters. In order to cope with the high rate, the TDCPix is equipped with four 3.2Gb/s serialisers sending out the data. We will describe the detector and the results from the 2014 NA62 ru...

  2. Status for 2018, CERN NA63

    CERN Document Server

    Nielsen, CF; Di Piazza, A; Wistisen, TN

    2018-01-01

    In the NA63 experiment of April 2018 the purpose was to look for the effect of the derivative term, the so-called Schott-term, in classical radiation reaction as described in \\cite{DiPiazza20171}. Data was taken for 20, 40 and 80 GeV electrons and positrons aligned to the $\\langle100\\rangle$ axis of a diamond crystal of thickness 1.5 mm, as well as for 40 and 80 GeV electrons on a 1.0 mm thick diamond aligned to the $\\langle100\\rangle$ axis. The data which was taken during the run shows encouraging results, but await a thorough analysis. For the 2017 data, the analysis is still ongoing, but expected to be finished within the coming few months. The results look very promising, but no final conclusion can be drawn at the present stage. For the 2016 results on quantum radiation reaction obtained by CERN NA63, the results have been published in Nature Communications \\cite{Wist17}.

  3. Direito do poeta na literatura de cordel

    Directory of Open Access Journals (Sweden)

    Sale Mário Gaudêncio

    Full Text Available Este artigo apresenta uma análise situacional dos direitos autorais na literatura de cordel, especialmente no que se refere à proteção moral e patrimonial que é dada aos poetas populares. Justifica-se o estudo em função de não haver profundas nem atuais discussões teóricas sobre a preservação moral e patrimonial em torno das obras de cordel. Utiliza-se como metodologia a pesquisa bibliográfica relacionada a um corpusque analisa os folhetos impressos por poetas da literatura de cordel. O estudo mostra como resultados o estabelecimento de um modelo alternativo de prazos para os direitos autorais na poesia popular, além da necessidade de ruptura técnica, política e cultural. Conclui informando sobre a importância de se construir um banco de dados nacional para que se tenha conhecimento pleno do quê e como se está produzindo a literatura de cordel, além de saber quem verdadeiramente está sendo beneficiado com tais produções.

  4. Plantas indicadoras de clomazone na fase vapor

    Directory of Open Access Journals (Sweden)

    Fábio Schreiber

    2013-10-01

    Full Text Available A volatilização representa um processo importante no deslocamento de agrotóxicos para o ambiente. As características físico-químicas da molécula do clomazone indicam que este possui potencial de volatilização. Em vista do exposto, para a realização deste estudo, foram conduzidos dois experimentos com o objetivo de avaliar a suscetibilidade das espécies: pepino, melão, milho, sorgo e arroz a diferentes formulações do herbicida clomazone na fase vapor. Para isso, foram utilizadas caixas de vidro hermeticamente fechadas, com a presença de diferentes formulações de clomazone e as espécies vegetais. As formulações utilizadas foram Gamit 360 CS®, Gamit 500 EC® e Gamit Star®. Com os resultados obtidos, foi possível concluir que, dentre as espécies avaliadas, independente da formulação utilizada, a de menor tolerância ao herbicida clomazone na fase vapor foi o sorgo, seguido do milho e do arroz.

  5. A biotecnologia na agropecuária

    Directory of Open Access Journals (Sweden)

    João Lúcio de Azevedo

    1986-11-01

    Full Text Available This review reports the use of biotechnology in agriculture and animal husbandry. The main techniques and the most important products both in experimental stage or in commercial use are reported. The work intends to give a global vision to the theme, chronologically and spacely, showing the main lines of research and what has been obtained in this area. The techniques and products that are related to genetics and breeding are emphasized. Revisão Bibliográfica do emprego da biotecnologia na agropecuária, mostrando um levantamento das técnicas mais promissoras e de seus principais produtos, tanto em fase experimental como em uso comercial. Pretende-se dar uma visão global do assunto, cronológica e espacialmente, não se prendendo à detalhes, mostrando, em Unhas gerais, o que foi feito e o que se faz, atualmente, em biotecnologia. As técnicas e produtos que influenciam a área de genética e melhoramento genético na agropecuária, são enfatizadas.

  6. Mercosul educativo na carreira de Enfermagem

    Directory of Open Access Journals (Sweden)

    Roseli Schmoeller

    2012-10-01

    Full Text Available O Mercosul, instituído com vistas à integração econômica, política, social e cultural entre os países membros, atualmente destaca-se pelas estratégias integrativas de âmbito educacional. Este artigo aborda os movimentos acerca da formação acadêmica dos cursos de Enfermagem e o trajeto histórico de integração educacional, apresentando o Sistema de Acreditação dos Cursos Universitários do Mercosul, o ARCU-SUL, além dos setores responsáveis por esse processo e as perspectivas para a Enfermagem nos países do Mercosul. Entendemos que para o desenvolvimento de profissionais críticos, reflexivos e com compromisso político-social, é fundamental investir na formação e na qualidade dos centros de ensino em Enfermagem.

  7. Mechanochemical transformations in Li(Na)AlH4-Li(Na)NH2 systems

    International Nuclear Information System (INIS)

    Dolotko, Oleksandr; Zhang Haiqiao; Ugurlu, Ozan; Wiench, Jerzy W.; Pruski, Marek; Scott Chumbley, L.; Pecharsky, Vitalij

    2007-01-01

    Mechanochemical transformations of tetrahydroaluminates and amides of lithium and sodium have been investigated using gas volumetric analysis, X-ray powder diffraction, solid-state nuclear magnetic resonance (NMR) and transmission electron microscopy. In a transformation of LiAlH 4 and LiNH 2 taken in an 1:1 molar ratio, the amount of released hydrogen (6.6 wt.% after 30 min ball milling) was higher than in any known one pot mechanochemical process involving a hydrogen-containing solid. A total of 4.3 wt.% of hydrogen is released by the NaAlH 4 -NaNH 2 system after 60 min ball milling; and 5.2 wt.% H 2 is released when LiAlH 4 and NaNH 2 or NaAlH 4 and LiNH 2 are ball milled for 90 min and 120 min, respectively. All transformations proceed at room temperature. The mechanism of the overall transformation MAlH 4 (s) + MNH 2 (s) → 2MH(s) + AlN(s) + 2H 2 (g) was identified based on detailed spectroscopic analysis of the intermediate (M 3 AlH 6 ) and final products of the ball milling process

  8. Aspectos valorizados por porfissionais de enfermagem na higiene pessoal e na higiene corporal do paciente

    Directory of Open Access Journals (Sweden)

    Elóide André Oliveira

    2003-10-01

    Full Text Available Survey descritivo, com o qual se objetivou identificar que aspectos da higiene corporal são valorizados pelos componentes da equipe de enfermagem, na higiene corporal pessoal e na higiene corporal do paciente. A pesquisa foi desenvolvida em oito instituições públicas de saúde e a amostra foi composta por 126 profissionais de enfermagem, correspondendo a 12,8% do total de 986 componentes das equipes de enfermagem destas instituições. Na higiene corporal pessoal, chamou a atenção o fato de que os cuidados com as unhas e com os cabelos tenham suplantado, no número de citações dos profissionais de enfermagem, aspectos básicos como o cuidado com as mãos. Na higiene corporal do paciente, o banho foi o aspecto considerado mais importante pelas três categorias profissionais; a higiene oral, pelas(os enfermeiras(os e auxiliares de enfermagem; e as unhas, pelas(os enfermeiras(os e técnicas(os de enfermagem.

  9. Excess Enthalpies of Mixing of Binary Mixtures of NaCl, KCl, NaBr ...

    African Journals Online (AJOL)

    NJD

    2004-07-01

    Jul 1, 2004 ... NaBr and KBr in Mixed Ternary Solvent Systems at 298.15 K. Bal Raj Deshwala* ... industrial waters and their thermodynamic properties are of practical interest for .... The enthalpy of mixing (∆Hm) is the difference between the excess enthalpy of the ..... tural (categorized by softness, open- ness, and ...

  10. Efeito do plasma de oxigênio na dentina previamente exposta ao NaOCl

    Directory of Open Access Journals (Sweden)

    Maíra do PRADO

    Full Text Available Resumo Introdução O tratamento de plasma é uma tecnologia eficaz que pode manter as propriedades internas dos materiais inalteradas após o tratamento, modificando apenas a superfície. Objetivo Avaliar o efeito do plasma de oxigênio na dentina previamente exposta ao NaOCl 6%. Material e método Foram utilizados 60 incisivos bovinos. A coroa foi removida, a raiz foi dividida e as faces planificadas, totalizando 120 segmentos referentes ao terço cervical. As amostras foram divididas em dois grupos: controle (imersa em NaOCl 6%, lavada com água destilada, seca, imersa em EDTA 17%, lavada e seca e plasma de oxigênio (após tratamento descrito no grupo controle, plasma de oxigênio foi aplicado por 30 s. As amostras foram avaliadas qualitativamente em relação à topografia por microscopia eletrônica de varredura, utilizando-se microfotografias com ampliação de 1.000×. O goniômetro Ramé-hart foi utilizado para a mensuração do ângulo de contato entre as superfícies e as seguintes soluções foram utilizadas: água, etilenoglicol e di-iodometano. Em seguida, a energia de superfície, representada pelas componentes polar e dispersiva, foi calculada. Avaliou-se também o escoamento dos cimentos Pulp Canal Sealer EWT (PCS e Real Sal SE (RS na superfície dentinária. Os dados foram analisados estatisticamente utilizando os testes Kruskal-Wallis e Mann-Whitney U (p<0,05. Resultado O tratamento com plasma levou à formação de uma camada semelhante à smear layer na superfície dentinária. Este tratamento levou a um aumento da energia de superfície e da componente polar, favorecendo a hidrofilicidade da superfície. Entretanto, desfavoreceu o escoamento do cimento PCS e não influenciou no escoamento do cimento RS. Conclusão O plasma de oxigênio ocasionou mudanças topográficas na superfície dentinária, favorecendo a hidrofilicidade desta. Contudo, não favoreceu o escoamento dos cimentos endodônticos na dentina.

  11. Stimulation of Na+/K+ ATPase activity and Na+ coupled glucose transport by β-catenin

    International Nuclear Information System (INIS)

    Sopjani, Mentor; Alesutan, Ioana; Wilmes, Jan; Dermaku-Sopjani, Miribane; Lam, Rebecca S.; Koutsouki, Evgenia; Jakupi, Muharrem; Foeller, Michael; Lang, Florian

    2010-01-01

    Research highlights: → The oncogenic transcription factor β-catenin stimulates the Na + /K + -ATPase. → β-Catenin stimulates SGLT1 dependent Na + , glucose cotransport. → The effects are independent of transcription. → β-Catenin sensitive transport may contribute to properties of proliferating cells. -- Abstract: β-Catenin is a multifunctional protein stimulating as oncogenic transcription factor several genes important for cell proliferation. β-Catenin-regulated genes include the serum- and glucocorticoid-inducible kinase SGK1, which is known to stimulate a variety of transport systems. The present study explored the possibility that β-catenin influences membrane transport. To this end, β-catenin was expressed in Xenopus oocytes with or without SGLT1 and electrogenic transport determined by dual electrode voltage clamp. As a result, expression of β-catenin significantly enhanced the ouabain-sensitive current of the endogeneous Na + /K + -ATPase. Inhibition of vesicle trafficking by brefeldin A revealed that the stimulatory effect of β-catenin on the endogenous Na + /K + -ATPase was not due to enhanced stability of the pump protein in the cell membrane. Expression of β-catenin further enhanced glucose-induced current (Ig) in SGLT1-expressing oocytes. In the absence of SGLT1 Ig was negligible irrespective of β-catenin expression. The stimulating effect of β-catenin on both Na + /K + ATPase and SGLT1 activity was observed even in the presence of actinomycin D, an inhibitor of transcription. The experiments disclose a completely novel function of β-catenin, i.e. the regulation of transport.

  12. Achados histeroscópicos em mulheres na pós-menopausa com diagnóstico de espessamento endometrial por ultra-sonografia transvaginal Hysteroscopic findings in postmenopausal women with endometrial thickening diagnosed by transvaginal ultrasound

    Directory of Open Access Journals (Sweden)

    Adriana Bittencourt Campaner

    2004-02-01

    Full Text Available OBJETIVO: correlacionar espessamento endometrial diagnosticado por ultra-sonografia com os achados histeroscópicos, em mulheres na pós-menopausa. MÉTODOS: foi realizado estudo transversal com avaliação histeroscópica em 121 mulheres na pós-menopausa, com diagnóstico de espessamento do endométrio por ultra-sonografia transvaginal. Das pacientes incluídas, 23 (19% recebiam diferentes esquemas de hormonioterapia e 98 não referiam uso de reposição hormnonal.; 55 pacientes queixavam-se de sangramento por via vaginal e as restantes apresentavam-se sem esta condição. Os exames endoscópicos foram realizados ambulatorialmente, utilizando-se histeroscópio rígido de 4 mm. Para a distensão da cavidade uterina empregou-se gás carbônico (CO2. Biópsia foi praticada em todas as pacientes, com auxílio de cureta tipo Novak, de 3 mm, e o material obtido submetido a estudo histopatológico. RESULTADOS: a espessura do endométrio variou entre 6 e 38 mm, com média de 10,7 ± 5,3 mm. Os achados histeroscópicos foram: lesão polipóide, em 51 pacientes (42,1%; endométrio atrófico, em 15 (12,4%; sinéquia senil, em 15 (12,4%; espessamento focal, em 13 (10,7%; lesão cerebróide, em 6 (5,0%; endométrio proliferativo, em 5 (4,1%; muco, em 5 (4,1%; mioma, em 4 (3,3%; endométrio secretor, em 3 (2,5%; hiperplasia endometrial, em 3 (2,5% e atrofia cística, em 1 (0,8%. Observou-se correlação entre os achados histeroscópicos e os resultados da histopatologia em 30 dos 51 casos de pólipo, em 12 dos 15 de endométrio atrófico e na totalidade dos casos sugestivos de hiperplasia endometrial e de adenocarcinoma. CONCLUSÃO: na maioria das pacientes, o exame histeroscópico revelou que não se tratava de real espessamento endometrial, mas sim de outras variedades de lesão da cavidade uterina.PURPOSE: to correlate endometrial thickening diagnosed by ultrasonography with hysteroscopic findings in postmenopausal women. METHODS: a transversal study

  13. RAZVOJ APLIKACIJE PRETOČNEGA VIDEA NA MOBILNEM TELEFONU

    OpenAIRE

    Horvat, Jernej

    2012-01-01

    Diplomsko delo obravnava prenos video signala iz mobilnega telefona na TV. Prenos poteka preko Wi-Fi omrežja. Na mobilnem telefonu je nameščena ustrezna Android aplikacija, ki omogoča direkten prenos video signala in nalaganje na TV sprejemnik. Pomemben dejavnik, ki prispeva, da je ta proces mogoč, je sistem IMS (IP multimedijski podsistem), ki predstavlja omrežja naslednje generacije.

  14. Razvoj suvremenog menadžmenta trgovine na malo

    OpenAIRE

    Segetlija, Zdenko

    2009-01-01

    Razvoj koncentracije u trgovini na malo doveo je do daljnjih promjena u njezinoj strukturi te, u skladu s tim, i do promjena u upravljanju gospodarskim subjektima u trgovini na malo. S tim u svezi mijenja se i dosadašnja paradigma marketinga trgovine na malo, budući da sve važnijim postaje oblikovanje asortimana temeljem programa category managementa i drugih oblika vertikalnoga marketinga. S druge pak strane, osim poznavanja zakonitosti razvoja novih oblika poslovnih jedinica, no...

  15. STABILIZACIJA ROBOTA NA ŽOGI IN KALMANOV FILTER

    OpenAIRE

    Turk, Janez

    2016-01-01

    Stabilizacija robota na žogi je dvodimenzionalen problem inverznega nihala (Segway). V magistrskem delu je opisana izdelava strojnega dela robota (konstrukcije in vezja), načrtovanje vseh uporabljenih algoritmov ter potek programa v digitalnem signalnem procesorju. Glavni problem, ki smo se mu najbolj posvetili, je slab podatek o nagibu, ki ga pridobimo z zlivanjem senzorskih podatkov giroskopa in pospeškometra. Za izboljšanje delovanja je še veliko rezerve pri načrtovanju regulatorjev. Poleg...

  16. Transcriptional regulators of Na, K-ATPase subunits

    OpenAIRE

    Zhiqin eLi; Sigrid A Langhans

    2015-01-01

    The Na,K-ATPase classically serves as an ion pump creating an electrochemical gradient across the plasma membrane that is essential for transepithelial transport, nutrient uptake and membrane potential. In addition, Na,K-ATPase also functions as a receptor, a signal transducer and a cell adhesion molecule. With such diverse roles, it is understandable that the Na,K-ATPase subunits, the catalytic alpha-subunit, the beta-subunit and the FXYD proteins, are controlled extensively during developme...

  17. K+ congeners that do not compromise Na+ activation of the Na+,K+-ATPase

    DEFF Research Database (Denmark)

    Mahmmoud, Yasser A; Kopec, Wojciech; Khandelia, Himanshu

    2015-01-01

    The Na(+),K(+)-ATPase is essential for ionic homeostasis in animal cells. The dephosphoenzyme contains Na(+) selective inward facing sites, whereas the phosphoenzyme contains K(+) selective outward facing sites. Under normal physiological conditions, K(+) inhibits cytoplasmic Na(+) activation...

  18. RAHNER NA BERLINDA PÓS-CONCILIAR

    Directory of Open Access Journals (Sweden)

    Luciano Campos Lavall

    2004-01-01

    Full Text Available O artigo analisa algumas críticas negativas feitas ao pensamento teológico de Karl Rahner, após sua morte, que tentam desqualificar a sua importância para a ortodoxia católica e o seu distanciamento dos fundamentos do Concílio Vaticano II. Na discussão, enfocada sobretudo no ponto de vista da eclesiologia rahneriana, retoma importante entrevista do mesmo, no ano de sua morte, na qual aparece a sua preocupação com as chances futuras da Igreja, sobretudo na Europa Ocidental, a partir da qual abordam-se as relações entre Cristianismo e Igreja. As estratégias para a organização pastoral do mundo católico são a tônica desta reflexão. Para justificar suas posturas, o artigo termina com uma avaliação global de todo o conjunto teológico de Karl Rahner, redescobrindo nele os pilares mais fundamentais que justificam sua ortodoxia a serviço da fé cristã e católica, mas também a serviço da tomada de consciência de uma fé vivenciada e comprometida por parte da humanidade marcadamente secularizada. ABSTRACT: The article analyses negative criticisms against Rahner’s theological views after his death with the intention of discrediting him and his role in Catholic orthodoxy by distancing him from the fundamentals of Vatican Council II. In the discussion, primarily focused on Rahner’s ecclesiology, the article retakes a significant interview made the same year of Rahner’s death. In this interview his concern for the Church’s future chances, especially regarding Eastern Europe, embarking on relations between Christianity and Church. The strategies for world-wide organization of Catholic ministry predominate this reflection. Justifying its postures, the article concludes with a global evaluation of Rahner’s theology, rediscovering the fundamental pillars which justify his orthodoxy at the service of the Christian and Catholic faith, but also at the service of a conscientious living of a committed faith on behalf of a notably

  19. Secretory NaCl and volume flow in renal tubules.

    Science.gov (United States)

    Beyenbach, K W

    1986-05-01

    This review attempts to give a retrospective survey of the available evidence concerning the secretion of NaCl and fluid in renal tubules of the vertebrate kidney. In the absence of glomerular filtration, epithelial secretory mechanisms, which to this date have not been elucidated, are responsible for the renal excretion of NaCl and water in aglomerular fish. However, proximal tubules isolated from glomerular fish kidneys of the flounder, killifish, and the shark also have the capacity to secrete NaCl and fluid. In shark proximal tubules, fluid secretion appears to be driven via secondary active transport of Cl. In another marine vertebrate, the sea snake, secretion of Na (presumably NaCl) and fluid is observed in freshwater-adapted and water-loaded animals. Proximal tubules of mammals can be made to secrete NaCl in vitro together with secretion of aryl acids. An epithelial cell line derived from dog kidney exhibits secondary active secretion of Cl when stimulated with catecholamines. Tubular secretion of NaCl and fluid may serve a variety of renal functions, all of which are considered here. The occurrence of NaCl and fluid secretion in glomerular proximal tubules of teleosts, elasmobranchs, and reptiles and in mammalian renal tissue cultures suggests that the genetic potential for NaCl secretion is present in every vertebrate kidney.

  20. Dejavniki psihološkega nasilja na delovnem mestu

    OpenAIRE

    Ilc, Teja

    2011-01-01

    Raziskave na področju delovnih razmer kažejo, da je danes pereč problem ravno psihološko nasilje na delovnem mestu. Posebna oblika psihološkega nasilja na delovnem mestu je mobing, s katerim se v praksi srečujemo vsak dan, vendar se ga pogosto ne zavedamo. Namen magistrske naloge je pojasniti pojem in pomen mobinga v delovnih organizacijah, poiskati možne vzroke in posledice, ki vplivajo na ta pojav, ter predlagati rešitve. Poznavanje mehanizmov, ki povzročajo mobing, njegovih vzrokov in...

  1. Angular distributions of photoelectrons from free Na clusters

    International Nuclear Information System (INIS)

    Wopperer, P.; Dinh, P. M.; Faber, B.; Reinhard, P.-G.; Suraud, E.

    2010-01-01

    We explore, from a theoretical perspective, photoelectron angular distributions (PADs) of the Na clusters Na 8 , Na 10 , Na 12 , Na 18 , Na 3 + , Na 11 + , Na 13 + , and Na 19 + . The basis of the description is the time-dependent local-density approximation (TDLDA), augmented by a self-interaction correction (SIC) to describe ionization properties correctly. The scheme is solved on a numerical grid in coordinate space with absorbing bounds. We assume for each cluster system an isotropic ensemble of free clusters and develop for the case of one-photon emission analytical formulas for computing the orientation-averaged PAD on the basis of a few TDLDA-SIC calculations for properly chosen reference orientations. It turns out that all the information in the averaged PAD is contained in one anisotropy parameter. We find that this parameter varies very little with system size, but as a whole is crucially influenced by the detailed ionic structure. We also make comparisons with direct orientation averaging and consider one example reaching outside the perturbative regime.

  2. Transcriptional regulators of Na, K-ATPase subunits

    Directory of Open Access Journals (Sweden)

    Zhiqin eLi

    2015-10-01

    Full Text Available The Na,K-ATPase classically serves as an ion pump creating an electrochemical gradient across the plasma membrane that is essential for transepithelial transport, nutrient uptake and membrane potential. In addition, Na,K-ATPase also functions as a receptor, a signal transducer and a cell adhesion molecule. With such diverse roles, it is understandable that the Na,K-ATPase subunits, the catalytic alpha-subunit, the beta-subunit and the FXYD proteins, are controlled extensively during development and to accommodate physiological needs. The spatial and temporal expression of Na,K-ATPase is partially regulated at the transcriptional level. Numerous transcription factors, hormones, growth factors, lipids and extracellular stimuli modulate the transcription of the Na,K-ATPase subunits. Moreover, epigenetic mechanisms also contribute to the regulation of Na,K-ATPase expression. With the ever growing knowledge about diseases associated with the malfunction of Na,K-ATPase, this review aims at summarizing the best-characterized transcription regulators that modulate Na,K-ATPase subunit levels. As abnormal expression of Na,K-ATPase subunits have been observed in many carcinoma, we will also discuss transcription factors that are associated with epithelial-to-mesenchymal transition, a crucial step in the progression of many tumors to malignant disease.

  3. O grotesco na imagem publicitária

    OpenAIRE

    Silva, Maria João Barros

    2013-01-01

    O significado da palavra grotesco teve um começo puramente artístico numa descoberta, de imagens de figuras humanas deformadas e alteradas. No entanto, este foi evoluindo e adotando novos significados mais amplos e concretos na atualidade. É possível encontrar vários exemplos do grotesco em várias plataformas, como no cinema, na televisão e na literatura. Neste sentido, para se poder proceder ao estudo desta temática é fundamental a conquista do conhecimento sobre o estatuto do grotesco na pu...

  4. VPLIV ULCEROZNEGA KOLITISA NA KAKOVOST ŽIVLJENJA

    OpenAIRE

    Dugi, Maja

    2015-01-01

    Pri vsaki bolezni je zelo pomembna kakovost življenja pacientov. Ulcerozni kolitis je kronična bolezen, ki je znana po obdobjih mirovanja in izbruhov, kar definitivno vpliva na posameznika, ki se s tem spopada. Sooča se z raznimi omejitvami, ki vplivajo na njegov vsakdan. Rezultati raziskave so pokazali, da je kakovost življenja bolnikov z ulceroznim kolitisom izrazito okrnjena. Ne le, da se spopadajo z bolečino, ampak tudi s psihičnimi in socialnimi posledicami, ki vplivajo na fizične aktivn...

  5. ZAZNAVA IN VPLIV BARV NA PRIMERU TISKANIH OGLASOV

    OpenAIRE

    Spes, Katja

    2015-01-01

    V diplomski nalogi smo s pomočjo literature opisali simboliko osnovnih barv, vpliv, ki ga imajo na ljudi, ter njihov pomen v oglasnih sporočilih. Omejili smo se na tiskane oglase (plakate, časopise, revije, neposredno pošto in embalažo) in opisali njihove prednosti in slabosti. Z anketnim vprašalnikom smo ugotavljali, na katere barve smo najbolj pozorni in katerim lastnostim se posamezne barve bolj približajo. Osredotočili smo se na sedem barv

  6. Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy.

    Science.gov (United States)

    Felippe Gonçalves-de-Albuquerque, Cassiano; Ribeiro Silva, Adriana; Ignácio da Silva, Camila; Caire Castro-Faria-Neto, Hugo; Burth, Patrícia

    2017-04-21

    Lung cancer is a leading cause of global cancer deaths. Na/K-ATPase has been studied as a target for cancer treatment. Cardiotonic steroids (CS) trigger intracellular signalling upon binding to Na/K-ATPase. Normal lung and tumour cells frequently express different pump isoforms. Thus, Na/K-ATPase is a powerful target for lung cancer treatment. Drugs targeting Na/K-ATPase may induce apoptosis and autophagy in transformed cells. We argue that Na/K-ATPase has a role as a potential target in chemotherapy in lung cancer treatment. We discuss the effects of Na/K-ATPase ligands and molecular pathways inducing deleterious effects on lung cancer cells, especially those leading to apoptosis and autophagy.

  7. Scintillation efficiency measurement of Na recoils in NaI(Tl) below the DAMA/LIBRA energy threshold

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Jingke; Shields, Emily; Calaprice, Frank; Westerdale, Shawn; Froborg, Francis; Suerfu, Burkhant; Alexander, Thomas; Aprahamian, Ani; Back, Henning O.; Casarella, Clark; Fang, Xiao; Gupta, Yogesh K.; Ianni, Aldo; Lamere, Edward; Lippincott, W. Hugh; Liu, Qian; Lyons, Stephanie; Siegl, Kevin; Smith, Mallory; Tan, Wanpeng; Kolk, Bryant Vande

    2015-07-01

    The dark matter interpretation of the DAMA modulation signal depends on the NaI(Tl) scintillation efficiency of nuclear recoils. Previous measurements for Na recoils have large discrepancies, especially in the DAMA/LIBRA modulation energy region. We report a quenching effect measurement of Na recoils in NaI(Tl) from 3 to 52 keVnr, covering the whole DAMA/LIBRA energy region for dark matter-Na scattering interpretations. By using a low-energy, pulsed neutron beam, a double time-of-flight technique, and pulse-shape discrimination methods, we obtained the most accurate measurement of this kind for NaI(Tl) to date. The results differ significantly from the DAMA reported values at low energies but fall between the other previous measurements. We present the implications of the new quenching results for the dark matter interpretation of the DAMA modulation signal.

  8. Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy

    Directory of Open Access Journals (Sweden)

    Cassiano Felippe Gonçalves-de-Albuquerque

    2017-04-01

    Full Text Available Lung cancer is a leading cause of global cancer deaths. Na/K-ATPase has been studied as a target for cancer treatment. Cardiotonic steroids (CS trigger intracellular signalling upon binding to Na/K-ATPase. Normal lung and tumour cells frequently express different pump isoforms. Thus, Na/K-ATPase is a powerful target for lung cancer treatment. Drugs targeting Na/K-ATPase may induce apoptosis and autophagy in transformed cells. We argue that Na/K-ATPase has a role as a potential target in chemotherapy in lung cancer treatment. We discuss the effects of Na/K-ATPase ligands and molecular pathways inducing deleterious effects on lung cancer cells, especially those leading to apoptosis and autophagy.

  9. A interdisciplinaridade na violência sexual

    OpenAIRE

    Azambuja,Maria Regina Fay de

    2013-01-01

    O artigo aborda a inquirição da vítima de violência sexual como afronta aos direitos humanos da criança, na medida em que busca a obtenção da prova em detrimento da proteção da vítima. Aponta a ação interdisciplinar como indispensável ao trabalho envolvendo violência sexual praticada contra a criança, dando ênfase à perícia realizada por profissionais de diversas áreas (Serviço Social, Psicologia, Pedagogia, Pediatra) como instrumento capaz de produzir a prova e de garantir a dignidade e o re...

  10. Symbiodinium isolation by NaOH treatment.

    Science.gov (United States)

    Zamoum, Thamilla; Furla, Paola

    2012-11-15

    The presence of photosynthetic zooxanthellae (dinoflagellates) in the tissue of many cnidarians is the main reason for their ecological success (i.e. coral reefs). It could also be the main cause of their demise, as the worldwide bleaching of reef-building coral is nothing less than the breakdown of this symbiotic association. The stability of this relationship is the principal marker for the biomonitoring of cnidarian health. We have therefore developed a new, simple method to isolate zooxanthellae in a few steps using NaOH solution. The protocol was validated in three symbiotic cnidarian species: a sea anemone, a gorgonian and a coral. Our method allows the isolation of intact and viable zooxanthellae with better yields than classic methods, especially for species with a calcareous skeleton. Moreover, the isolated zooxanthellae were free of host nucleic contaminants, facilitating subsequent specific molecular analyses.

  11. Pion and kaon freezeout in NA44

    International Nuclear Information System (INIS)

    1994-01-01

    The NA44 spectrometer is optimized for the study of single and two-particle particle spectra near mid-rapidity for transverse momenta below ∼ 1 GeV/c. A large fraction of all pairs in the spectrometer's acceptance are at low relative momenta, resulting in small statistical uncertainties on the extracted size parameters. In addition, the spectrometer's clean particle identification allows the authors to measure correlation functions for pions, kaons, and protons. This contribution will concentrate on the source size parameters determined from pion and kaon correlation functions. These size parameters will be compared to calculations from the RQMD event generator and also interpreted in the context of a hydrodynamic model. Finally, the measured single particle spectra will be examined from the viewpoint of hydrodynamics

  12. Redes sociais na internet: Sociabilidades emergentes

    OpenAIRE

    Amaral, Inês

    2016-01-01

    Na actual era da cultura digital é imperativo identificar e compreender os tipos de sociabilidade que emergem das novas práticas e relações que ocorrem no ciberespaço, para que seja possível teorizar sobre realidades sociais que são desenhadas em torno da apropriação do conteúdo e materializadas em plataformas que se assumem como o termómetro de uma sociedade sem determinismo geográfico. A sociabilização em contexto digital reporta-se ao princípio de que um mundo de informação (conteúdos, ...

  13. O operar de um coletivo na WEB

    Directory of Open Access Journals (Sweden)

    Karen Eidelwein

    Full Text Available Analisamos o operar de um grupo de discussão na WEB buscando identificar seu agenciamento enquanto coletivo autoprodutivo. Estabelecemos sete indicadores de operação e cinco categorias temáticas. A visualização de cada um dos indicadores de operação em cada uma das categorias temáticas possibilitou compreender o operar do grupo como decorrente das próprias relações que foram sendo estabelecidas, em um processo autoprodutivo, de causalidade recursiva. Foi possível argumentar que o grupo apresentou indícios de um modo de instituir-se capaz de apontar para outras formas de relação em torno da construção de objetos coletivos teóricos voltados para a ação fora do espaço digital.

  14. Bullying: ato esburacado na angústia

    Directory of Open Access Journals (Sweden)

    Maria de Lourdes Soares Ornellas

    2012-04-01

    Full Text Available A noção de afeto está no campo do (desprazer, resultante de uma experiência afetiva de satisfação ou insatisfação, e que se manifesta nas necessidades do sujeito. Pode-se dizer que o afeto envolve a ambivalência de sentimentos, do mais agradável ao mais insuportável, e desempenha um papel estruturante para que o sujeito reencontre sua estrutura psíquica, exercendo uma ação mediadora e decisiva sobre a constituição do sujeito do desejo, orientando o seu projeto de vida, sua profissão, sua opção sexual, etc. Essa ambivalência de afetos deve ser exercitada na educação familiar e escolar, na fala e na escuta que o afeto (desprazeroso tem relevância e parece ser silenciado. O desprazer pode ser escandido pelos sintomas medo, depressão, irritabilidade, ansiedade, humilhação. Assim posto o bullying é também conhecido como a síndrome da humilhação. O objetivo da humilhação é a tentativa de destruição do sujeito; a perda da identificação revela um fantasma, na medida em que própria vítima se sente culpada por sofrer ou por estar sofrendo um ato esburacado porque uma das peças não é encontrada e, em lugar do encaixe, o que se mostra é um buraco, o que provoca a angústia entre quem perde e aquele que ganha. ABSTRACT: The notion of affect is thus in the field of (dis pleasure, resulting from an affective experience of satisfaction or dissatisfaction, and that manifests itself on the needs of the subject. You could say that the affection involves the ambivalence of feelings, the more enjoyable the more unbearable, and plays a structural role for the subject to rediscover his psychic structure, exerting a mediator and decisive action on the constitution of the subject of desire, directing the its design life, your profession, your sexual orientation, etc.. This ambivalence of feelings should be exercised in family education and school, talking and listening that affect (dis pleasure is relevant and appears to be

  15. The NA49 large acceptance hadron detector

    International Nuclear Information System (INIS)

    Afanasiev, S.; Alber, T.; Appelshaeuser, H.; Baechler, J.; Barna, D.; Barnby, L.S.; Bartke, J.; Barton, R.A.; Betev, L.; Bialkowska, H.; Bieser, F.; Billmeier, A.; Blyth, C.O.; Bock, R.; Bormann, C.; Bracinik, J.; Brady, F.P.; Brockmann, R.; Brun, R.; Buncic, P.; Caines, H.L.; Cebra, D.; Cooper, G.E.; Cramer, J.G.; Csato, P.; Cyprian, M.; Dunn, J.; Eckardt, V.; Eckhardt, F.; Empl, T.; Eschke, J.; Ferguson, M.I.; Fessler, H.; Fischer, H.G.; Flierl, D.; Fodor, Z.; Frankenfeld, U.; Foka, P.; Freund, P.; Friese, V.; Ftacnik, J.; Fuchs, M.; Gabler, F.; Gal, J.; Ganz, R.; Gazdzicki, M.; Gladysz, E.; Grebieszkow, J.; Guenther, J.; Harris, J.W.; Hegyi, S.; Henkel, T.; Hill, L.A.; Hlinka, V.; Huang, I.; Huemmler, H.; Igo, G.; Irmscher, D.; Ivanov, M.; Janik, R.; Jacobs, P.; Jones, P.G.; Kadija, K.; Kolesnikov, V.I.; Kowalski, M.; Lasiuk, B.; Levai, P.; Liebicher, K.; Lynen, U.; Malakhov, A.I.; Margetis, S.; Markert, C.; Marks, C.; Mayes, B.; Melkumov, G.L.; Mock, A.; Molnar, J.; Nelson, J.M.; Oldenburg, M.; Odyniec, G.; Palla, G.; Panagiotou, A.D.; Pestov, Y.; Petridis, A.; Pikna, M.; Pimpl, W.; Pinsky, L.; Piper, A.; Porter, R.J.; Poskanzer, A.M.; Poziombka, S.; Prindle, D.J.; Puehlhofer, F.; Rauch, W.; Reid, J.G.; Renfordt, R.; Retyk, W.; Ritter, H.G.; Roehrich, D.; Roland, C.; Roland, G.; Rudolph, H.; Rybicki, A.; Sammer, T.; Sandoval, A.; Sann, H.; Schaefer, E.; Schmidt, R.; Schmischke, D.; Schmitz, N.; Schoenfelder, S.; Semenov, A.Yu.; Seyboth, J.; Seyboth, P.; Seyerlein, J.; Sikler, F.; Sitar, B.; Skrzypczak, E.; Squier, G.T.A.; Stelzer, H.; Stock, R.; Strmen, P.; Stroebele, H.; Struck, C.; Susa, T.; Szarka, I.; Szentpetery, I.; Szymanski, P.; Sziklai, J.; Toy, M.; Trainor, T.A.; Trentalange, S.; Ullrich, T.; Vassiliou, M.; Veres, G.; Vesztergombi, G.; Vranic, D.; Wang, F.Q.; Weerasundara, D.D.; Wenig, S.; Whitten, C.; Wieman, H.; Wienold, T.; Wood, L.; Yates, T.A.; Zimanyi, J.; Zhu, X.-Z.; Zybert, R.

    1999-01-01

    The NA49 detector is a wide acceptance spectrometer for the study of hadron production in p+p, p+A, and A+A collisions at the CERN SPS. The main components are 4 large-volume TPCs for tracking and particle identification via dE/dx. TOF scintillator arrays complement particle identification. Calorimeters for transverse energy determination and triggering, a detector for centrality selection in p+A collisions, and beam definition detectors complete the set-up. A description of all detector components is given with emphasis on new technical realizations. Performance and operational experience are discussed in particular with respect to the high track density environment of central Pb+Pb collisions

  16. The NA49 large acceptance hadron detector

    CERN Document Server

    Afanasiev, S V; Appelshäuser, H; Bächler, J; Barna, D; Barnby, L S; Bartke, Jerzy; Barton, R A; Betev, L; Bialkowska, H; Bieser, F; Billmeier, A; Blyth, C O; Böck, R K; Bormann, C; Bracinik, J; Brady, F P; Brockmann, R; Brun, R; Buncic, P; Caines, H L; Cebra, D; Cooper, G E; Cramer, J G; Csató, P; Cyprian, M; Dunn, J; Eckardt, V; Eckhardt, F; Empl, T; Eschke, J; Ferguson, M I; Fessler, H; Fischer, H G; Flierl, D; Fodor, Z; Frankenfeld, Ulrich; Foka, P Y; Freund, P; Friese, V; Ftácnik, J; Fuchs, M; Gabler, F; Gál, J; Ganz, R E; Gazdzicki, M; Gladysz-Dziadus, E; Grebieszkow, J; Günther, J; Harris, J W; Hegyi, S; Henkel, T; Hill, L A; Hlinka, V; Huang, I; Hümmler, H; Igo, G; Irmscher, D; Ivanov, M; Janik, R; Jacobs, P; Jones, P G; Kadija, K; Kolesnikov, V I; Kowalski, M; Lasiuk, B; Lévai, Peter; Liebicher, K; Lynen, U; Malakhov, A I; Margetis, S; Markert, C; Marks, C; Mayes, B W; Melkumov, G L; Mock, A; Molnár, J; Nelson, J M; Oldenburg, M; Odyniec, Grazyna Janina; Pálla, G; Panagiotou, A D; Pestov, Yu N; Petridis, A; Pikna, M; Pimpl, W; Pinsky, L; Piper, A; Porter, R J; Poskanzer, A M; Poziombka, S; Prindle, D J; Pühlhofer, F; Rauch, W; Reid, J G; Renfordt, R E; Retyk, W; Ritter, H G; Röhrich, D; Roland, C; Roland, G; Rudolph, H; Rybicki, A; Sammer, T; Sandoval, A; Sann, H; Schäfer, E; Schmidt, R; Schmischke, D; Schmitz, N; Schönfelder, S; Semenov, A Yu; Seyboth, J; Seyboth, P; Seyerlein, J; Siklér, F; Sitár, B; Skrzypczak, E; Squier, G T A; Stelzer, H; Stock, Reinhard; Strmen, P; Ströbele, H; Struck, C; Susa, T; Szarka, I; Szentpétery, I; Szymanski, P; Sziklai, J; Toy, M; Trainor, T A; Trentalange, S; Ullrich, T S; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wang, F; Weerasundara, D D; Wenig, S; Whitten, C; Wieman, H H; Wienold, T; Wood, L; Yates, T A; Zimányi, J; Zhu, X Z; Zybert, R

    1999-01-01

    The NA49 detector is a wide acceptance spectrometer for the study of hadron production in p+p, p+A, and A+A collisions at the CERN SPS. The main components are 4 large volume TPCs for tracking and particle identification via $dE/dx$. TOF scintillator arrays complement particle identification. Calorimeters for transverse energy determination and triggering, a detector for centrality selection in p+A collisions, and beam definition detectors complete the set-up. A description of all detector components is given with emphasis on new technical realizations. Performance and operational experience are discussed in particular with respect to the high track density environment of central Pb+Pb collisions.

  17. Hotel na Vysočině

    OpenAIRE

    Machatka, Petr

    2013-01-01

    Diplomová práce s názvem Hotel na Vysočině řeší projektovou dokumentaci ve stupni pro provedení stavby. Hotel má tři nadzemní podlaží. Objekt je nepodsklepený. Zastřešení je provedeno plochou a šikmou střechou. Zdící systém POROTHERM s kontaktním zateplením expandovaným polystyrenem EPS -F. The master thesis named Hotel at Vysočina solves project documentation in the degree for building construction. The hotel has three floors. The object is without a cellar. As roofing is used a flat and ...

  18. O retorno do religioso na contemporaneidade

    Directory of Open Access Journals (Sweden)

    Tiago Ribeiro Nunes

    2008-12-01

    Full Text Available O presente trabalho pretende analisar os novos modos de relação, entre a civilização e o sagrado, que emergem no contexto da contemporaneidade. Partindo principalmente das formulações freudianas e lacanianas sobre o tema, nosso objetivo primordial ao longo deste artigo é estabelecer parâmetros para compreender a ocorrência do "retorno ao sagrado no exato momento em que a humanidade enfrenta crises cada vez mais profundas e permanentes. Tal empreendimento nos permitirá verificar até que ponto o fortalecimento dos movimentos religiosos pode ser considerado como uma das conseqüências da queda dos referenciais que se realiza na contemporaneidade.

  19. Estágio na Compta

    OpenAIRE

    Mendes, Dário Miguel dos Santos

    2017-01-01

    O presente documento descreve o trabalho realizado no segundo ano letivo do Mestrado em Produção de Conteúdos Digitais. Relatando um estágio decorrido na empresa tecnológica Compta S.A. Neste relatório é feita uma apresentação da empresa, bem como os seus objetivos como tal. De seguida, efetua-se um enquadramento do estágio no âmbito contextual dos conteúdos digitais, descrevendo as tecnologias utilizadas, necessárias à criação de aplicações para dispositivos móveis. São ainda apresentados...

  20. Solubility of NaNd(CO3)2.6H2O(c) in concentrated Na2CO3 and NaHCO3 solutions

    International Nuclear Information System (INIS)

    Rao, L.; Rai, D.; Felmy, A.R.; Fulton, R.W.; Novak, C.F.

    1996-01-01

    NaNd(CO 3 ) 2 x 6 H 2 O(c) was identified to be the final equilibrium solid phase in suspensions containing concentrated sodium carbonate (0.1 to 2.0 M) and sodium bicarbonate (0.1 to 1.0 M), with either NaNd(CO 3 ) 2 x 6 H 2 O(c) or Nd 2 (CO 3 ) 3 x xH 2 O(s) as initial solids. A thermodynamic model, based on Pitzer's specific into-interaction approach, was developed to interpret the solubility of NaNd(CO 3 ) 2 x 6 H 2 O(c) as functions of sodium carbonate and sodium bicarbonate concentrations. In this model, the solubility data of NaNd(CO 3 ) 2 x 6 H 2 O(c) were explained by assuming the formation of NdCO 3 + , Nd(CO 3 ) 2 - and Nd(CO 3 ) 3 3- species and invoking the specific ion interactions between Na + and Nd(CO 3 ) 3 3- . Ion interaction parameters for Na + -Nd(CO 3 ) 3 3- were developed to fit the solubility data. Based on the model calculations, Nd(CO 3 ) 3 3- was the predominant aqueous neodymium species in 0.1 to 2 M sodium carbonate and 0.1 to 1 M sodium bicarbonate solutions. The logarithm of the NaNd(CO 3 ) 2 x 6 H 2 O solubility product (NaNd(CO 3 ) 2 x 6 H 2 O(c)=Na + +Nd 3+ +2 CO 3 2- +6 H 2 O) was calculated to be -21.39. This model also provided satisfactory interpretation of the solubility data of the analogous Am(III) system in less concentrated carbonate and bicarbonate solutions. (orig.)

  1. Videogames e o aprender na complexidade

    Directory of Open Access Journals (Sweden)

    Paula Cristina Turcatto

    2016-06-01

    Full Text Available Ao conceber-se esta pesquisa, levou-se em consideração que cada ser humano aprende do seu modo pessoal e único, portanto, a proposta é pensar os videogames na sua relação com o Paradigma da Complexidade. Esta pesquisa teve como objetivo proporcionar um ambiente de encontro com diversos jogos de videogame, buscando instaurar a experimentação do novo, a abertura para o conhecer, ao habitar espaços inventivos, que valorizam a plasticidade e flexibilidade. Trata-se de uma pesquisa qualitativa, pois se propôs a trabalhar com os aspectos subjetivos como uma dimensão inseparável do conhecer. Foram 8 sujeitos de pesquisa – adolescentes – com os quais foram realizados 15 encontros, nos quais os mesmos estiveram em contato com diversos jogos de videogame. Foram utilizados diários de bordo para o registro das vivências, ancorados na metodologia cartográfica para tratamento dos registros. Os videogames propiciaram espaços para a emergência de diferentes formas de vivenciar a narrativa. Apesar de os jogos serem pré-moldados, os percursos produzidos, assim como as produções simbólicas frente ao contexto do jogo foram individuais. Jogar videogame relacionou-se ao posicionamento criador, de escrever as circunstâncias sob as quais as ações do jogo refletiram nas experiências vivenciadas pelo jogador.

  2. Insulin regulation of (Na+, K+)-ATPase

    International Nuclear Information System (INIS)

    Lytton, J.

    1985-01-01

    This thesis describes an investigation into the mechanism of insulin stimulation of (Na + ,K + )=ATPase in rat adipocytes. Two molecular forms of the catalytic subunit of the enzyme were identified and denoted α and α(+), due to their similarity to those isozymes previously described from rat brain. Insulin specifically stimulated the α(+) form of the enzyme. The two forms of the enzyme had quite different affinities for intracellular sodium ion; insulin affected only the lower affinity of α(+), shifting it toward a higher value. However, the sodium affinity of (Na + ,K + )-ATPase activity in isolated membranes was equally high for both forms of the enzyme. This suggests that the difference in sodium affinity between the two forms observed in the cell is not inherent within the structure of the sodium pump, but must depend upon a selective interaction with another molecule which has been lost upon membrane isolation. Immunoprecipitation of both the catalytic subunits either from extracts of whole cells which had been labelled with [ 32 P] orthophosphate, or from membranes which had been labelled with γ-[ 32 P]ATP demonstrated that less than 1 in 100 molecules had a covalently bound phosphate insulin had no influence on this value. The amino terminal sequences of the first 4 amino acids of the catalytic subunits of both α (isolated from rat kidney) and α(+) (from rat brainstem axolemma) were determined. The result shows two highly homologous but clearly different molecules. It can thus be concluded that the insulin sensitive version of the enzyme is not derived from the common α form by a post-translational modification

  3. Porta-enxertos utilizados na citricultura

    Directory of Open Access Journals (Sweden)

    Schäfer Gilmar

    2001-01-01

    Full Text Available A muda cítrica é o insumo mais importante na formação de um pomar. As características mais importantes da muda cítrica são a origem do enxerto e do porta-enxerto, a qualidade do sistema radicular e a sua sanidade. Os porta-enxertos são capazes de influenciar várias características horticulturais e sanitárias nas árvores e nos frutos cítricos, como: sólidos solúveis totais, tamanho da copa e do fruto, resistência a moléstias e ao frio, distribuição da raízes, etc. O principal porta-enxerto utilizado no Brasil (cerca de 80% é o limoeiro ?Cravo? (Citrus limonia Osbeck cv. Cravo. No Rio Grande do Sul, mais especificamente, destaca-se o Poncirus trifoliata (L. Raf em mais de 90% dos pomares. Isso torna a citricultura vulnerável ao surgimento de moléstias que afetem estes porta-enxertos, como ocorreu na década de 40 em todo o Brasil com a 'Tristeza' dos citros em plantas enxertadas sobre laranjeira azeda, e, mais recentemente, com o 'declínio'. Assim, o conhecimento das características dos diversos porta-enxertos e de algumas particularidades do uso destes é de grande importância para a diversificação e escolha do porta-enxerto a ser utilizado pelo citricultor.

  4. PERSPECTIVA MULTIDIMENSIONAL DO TRABALHO NA CONTEMPORANEIDADE

    Directory of Open Access Journals (Sweden)

    Lilian Carminatti

    2015-12-01

    Full Text Available O objetivo deste estudo é analisar a evolução do tema trabalho e novas formas de flexibilização das relações laborais que proporcionam identidade, significado e bem-estar. O trabalho, como uma atividade prazerosa, passa por uma mudança de postura das pessoas frente à atividade ocupacional, a partir do autoconhecimento, planejamento de carreira e de uma jornada de trabalho que vislumbre a melhora na qualidade de vida. A promoção do bem-estar presume a articulação entre as relações de trabalho atravessadas pelo sistema capitalista e a importância de equilibrar necessidades individuais e a competitividade organizacional. Como elementos balizadores surgem: a relação com os significados do trabalho, o planejamento de carreira e pós-carreira e a conexão entre valores pessoais e organizacionais. Adotou-se para a pesquisa uma estratégia metodológica qualitativa que se propõe a investigar a partir da exploração e descrição as dimensões do tema trabalho na sociedade contemporânea. Dessa forma, a promoção do bem-estar e o planejamento de carreira devem ser tratados como planejamento de vida durante todo o período funcional, a partir de uma visão multidimensional do colaborador inserida em um amplo contexto cultural e social que ultrapassa o ambiente organizacional.

  5. Mercury's Na Exosphere from MESSENGER Data

    Science.gov (United States)

    Killen, Rosemary M.; Burger, M. H.; Cassidy, T. A.; Sarantos, M.; Vervack, R. J.; McClintock, W. El; Merkel, A. W.; Sprague, A. L.; Solomon, S. C.

    2012-01-01

    MESSENGER entered orbit about Mercury on March 18, 2011. Since then, the Ultraviolet and Visible Spectrometer (UWS) channel of MESSENGER's Mercury Atmospheric and Surface Composition Spectrometer (MASCS) has been observing Mercury's exosphere nearly continuously. Daily measurements of Na brightness were fitted with non-uniform exospheric models. With Monte Carlo sampling we traced the trajectories of a representative number of test particles, generally one million per run per source process, until photoionization, escape from the gravitational well, or permanent sticking at the surface removed the atom from the simulation. Atoms were assumed to partially thermally accommodate on each encounter with the surface with accommodation coefficient 0.25. Runs for different assumed source processes are run separately, scaled and co-added. Once these model results were saved onto a 3D grid, we ran lines of sight from the MESSENGER spacecraft :0 infinity using the SPICE kernels and we computed brightness integrals. Note that only particles that contribute to the measurement can be constrained with our method. Atoms and molecules produced on the nightside must escape the shadow in order to scatter light if the excitation process is resonant-light scattering, as assumed here. The aggregate distribution of Na atoms fits a 1200 K gas, with a PSD distribution, along with a hotter component. Our models constrain the hot component, assumed to be impact vaporization, to be emitted with a 2500 K Maxwellian. Most orbits show a dawnside enhancement in the hot component broadly spread over the leading hemisphere. However, on some dates there is no dawn/dusk asymmetry. The portion of the hot/cold source appears to be highly variable.

  6. LUZ, MELATONINA E ESTRESSE OXIDATIVO NA PISCICULTURA

    Directory of Open Access Journals (Sweden)

    Claudio Alberto Gellis de Mattos Dias

    2013-12-01

    Full Text Available Em peixes, como nos mamíferos, partes do sistema nervoso estão envolvidas em mecanismos para regulação dos sistemas corporais em sintonia com o meio. O fotoperíodo é traduzido em informações fisiológicas a partir da secreção de melatonina.Parece não haver barreiras morfofisiológicas para esta indolamina, isto é, a melatonina perfunde-se rapidamente em cada célula do organismo e em alguns casos interage com receptores e membrana situados na superfície celular, e parece estar ligada à ingestão de alimentos, crescimento e atividade locomotora de peixes. São moléculas importantes metabolizando espécies reativas de oxigênio a produtos inativos e, portanto, reduzindo o dano oxidativo.Este trabalho tem por objetivo fazer um breve levantamento em artigos recentes sobre luminosidade, melatonina e o estresse oxidativo em peixes, e correlaciona-los com piscicultura. Concluímos que a luminosidade parece estar ligada a produção de melatonina, e esta molécula antioxidante, que favorece a redução do estresse oxidativo, parecem melhorar o desempenho na produção de peixes em criadouros. Palavras-chave: Melatonina, estresse oxidativo, piscicultura. DOI: http://dx.doi.org/10.18561/2179-5746/biotaamazonia.v3n3p169-176

  7. Diffusion of calcium in pure and doped NaCl; Diffusion du calcium dans NaCl pur et dope

    Energy Technology Data Exchange (ETDEWEB)

    Slifkin, L; Brebec, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1969-07-01

    We have determined, by diffusion experiments of Ca in pure and doped NaCl, the activation energy for the calcium jumps and the binding energy between calcium ion and vacancy. (authors) [French] Nous avons determine, par des mesures de diffusion du Ca dans NaCl pur et NaCl dope avec CaCl{sub 2}, l'energie d'activation relative aux sauts du calcium et l'energie de liaison lacune-calcium. (auteurs)

  8. Mechanism of μ-conotoxin PIIIA binding to the voltage-gated Na+ channel NaV1.4.

    Directory of Open Access Journals (Sweden)

    Rong Chen

    Full Text Available Several subtypes of voltage-gated Na+ (NaV channels are important targets for pain management. μ-Conotoxins isolated from venoms of cone snails are potent and specific blockers of different NaV channel isoforms. The inhibitory effect of μ-conotoxins on NaV channels has been examined extensively, but the mechanism of toxin specificity has not been understood in detail. Here the known structure of μ-conotoxin PIIIA and a model of the skeletal muscle channel NaV1.4 are used to elucidate elements that contribute to the structural basis of μ-conotoxin binding and specificity. The model of NaV1.4 is constructed based on the crystal structure of the bacterial NaV channel, NaVAb. Six different binding modes, in which the side chain of each of the basic residues carried by the toxin protrudes into the selectivity filter of NaV1.4, are examined in atomic detail using molecular dynamics simulations with explicit solvent. The dissociation constants (Kd computed for two selected binding modes in which Lys9 or Arg14 from the toxin protrudes into the filter of the channel are within 2 fold; both values in close proximity to those determined from dose response data for the block of NaV currents. To explore the mechanism of PIIIA specificity, a double mutant of NaV1.4 mimicking NaV channels resistant to μ-conotoxins and tetrodotoxin is constructed and the binding of PIIIA to this mutant channel examined. The double mutation causes the affinity of PIIIA to reduce by two orders of magnitude.

  9. Anisotropy and polarization in charge changing collisions of C4+ with Na(3s) and laser aligned Na(3p)

    NARCIS (Netherlands)

    Hoekstra, R; Morgenstern, R; Olson, RE

    1996-01-01

    Absolute cross sections for C3+(6-->5) emission at 465.7 nm after collisions of C4+ ions with ground state Na(3s) and laser excited aligned Na(Sp) atoms are measured over the collision energy range of 3-7 keV amu(-1). For Na(3s) polarizations are observed by measuring the linear polarization of the

  10. Avaliação das alterações fundoscópicas na miopia degenerativa Fundus changes evaluation in degenerative myopia

    Directory of Open Access Journals (Sweden)

    Oswaldo Ferreira Moura Brasil

    2006-04-01

    Full Text Available OBJETIVO: Avaliar a presença de alterações fundoscópicas em pacientes portadores de miopia degenerativa. MÉTODOS: Quarenta pacientes com erro refrativo de pelo menos -6,00 dioptrias foram selecionados para exame oftalmológico, complementado por retinografia do pólo posterior e ecobiometria. RESULTADOS: Foram estudados 57 olhos de 37 pacientes com erro refrativo de -6,25 a -28,50 dioptrias, com média de -14,05, e comprimento axial de 26,06 a 32,86 mm, com média de 28,01. Encontramos crescente temporal em 36,5% e circunferencial em 21% dos olhos. Vasos da coróide foram visualizados em 35% dos olhos. As alterações do pólo posterior foram as seguintes: estafiloma posterior em 10,5%, mancha de Fuchs em 3,5% e "lacquer cracks" em 1,5%. O exame da periferia retiniana evidenciou atrofia corio-retiniana tipo pavimentosa em 17,5%, branco sem pressão em 10,5%, degeneração "lattice" em 5%, ruptura retiniana em 3,5% e retinosquise em 1,5% dos olhos examinados. CONCLUSÕES: Alterações fundoscópicas que levam à baixa visual são freqüentes em pacientes com miopia degenerativa. O exame da periferia retiniana é muito importante nestes pacientes devido ao risco aumentado de descolamento de retina.PURPOSE: To evaluate the presence of fundus changes in degenerative myopia. METHODS: Forty patients with refractive error of at least -6.00 diopters were selected for ophthalmologic examination followed by posterior pole photograph and echobiometry. RESULTS: We studied 57 eyes of 37 patients with refractive error ranging from -6.25 to -28.50 diopters, with mean -14.05, and axial length ranging from 26.06 to 32.86 mm, with mean 28.01. We found a temporal crescent in 36.5% and a peripapillary one in 20% of the eyes. Choroidal vessels were seen in 35% of the eyes. Posterior pole changes were as follow: posterior staphyloma in 10.5%, Fuchs' spots in 3.5% and lacquer cracks in 1.5%. Peripheral retinal examination revealed paving stone chorioretinal

  11. Crystal structure of polyphosphates NaCd(PO3)3 and NaMn(PO3)3

    International Nuclear Information System (INIS)

    Murashova, E.V.; Chudinova, N.N.

    1997-01-01

    Crystal structure of NaCd(PO 3 ) 3 (1) and NaMn(PO 3 ) 3 (2) isostructural polyphosphates was determined for twin samples. Rhombic lattice parameters of (1): a = 14.678, b = 14.669, c = 14.705 A, sp. gr. P2 1 2 1 2 1 , Z = 16. The structure of compounds is of frame type. Polyphosphate chain with repetition period of 24 PO 4 tetrahedrons contacts with NaO 6 and M 2 O 6 octahedrons by means of common oxygen vertices. Similarities and differences in structure of mentioned polyphosphates and earlier analyzed NaMg(PO 3 ) 3 polyphosphate are noted [ru

  12. UTJECAJ POZITIVNE DISKRIMINACIJE NA UKLJUČIVANJE ŽENA NA TRŽIŠTE RADA U REPUBLICI HRVATSKOJ

    OpenAIRE

    Dovranić, Dora; Katavić, Ivica

    2016-01-01

    U početku 21. stoljeća često se koristi pojam pozitivne (afirmativne) diskriminacije. Pozitivna diskriminacija mjera je koju poduzima vlada, neka organizacija ili korporacija s ciljem da se smanje nejednakosti u društvu nastale upravo diskriminacijom, na način da se pružaju određene povlastice onima koji su pretrpjeli neku vrstu diskriminacije. Nastala je u Sjedinjenim Američkim Državama na inicijativu predsjednika Kennedyja, Johnsona i Nixona. Diskriminacija, nažalost, ima mnogo oblika, a ne...

  13. 43. Calmodulin regulating calcium sensitivity of Na channels

    Directory of Open Access Journals (Sweden)

    R. Vegiraju

    2016-07-01

    Full Text Available By extrapolating information from existing research and observing previous assumptions regarding the structure of the Na Channel, this experiment was conducted under the hypothesis that the Na Channel is in part regulated by the calmodulin protein, as a result proving calcium sensitivity of the Na Channel. Furthermore, we assume that there is a one to one stoichiometry between the Na Channel and the Calmodulin. There has been extensive research into the functionality and structure of sodium ion channels (Na channels, as several diseases are associated with the lack of regulation of sodium ions, that is caused by the disfunction of these Na channels. However, one highly controversial matter in the field is the importance of the protein calmodulin (CaM and calcium in Na channel function. Calmodulin is a protein that is well known for its role as a calcium binding messenger protein, and that association is believed to play an indirect role in regulating the Na channel through the Na channel’s supposed calcium sensitivity. While there are proponents for both sides, there has been relatively little research that provides strong evidence for either case. In this experiment, the effect of calmodulin on NaV 1.5 is tested by preparing a set of cardiac cells (of the human specie with the NaV 1.5 C-Termini and CaM protein, which were then to be placed in solutions with varying concentrations of calcium. We took special care to test multiple concentrations of calcium, as previous studies have tested very low concentrations, with Manu Ben-Johny’s team from the John Hopkins laboratory in particular testing up to a meager 50 micromolar, despite producing a well-respected paper (By comparison, the average Na channel can naturally sustain a concentration of almost 1-2 millimolar and on some occasions, reaching even higher concentrations. After using light scattering and observing the signals given off by the calcium interacting with these Nav1.5/Ca

  14. Impact of childhood stress on psychopathology Impacto de estresse na infância na psicopatologia

    Directory of Open Access Journals (Sweden)

    Elisa Brietzke

    2012-12-01

    Full Text Available OBJECTIVE: Advances in our knowledge of mental disorder (MD genetics have contributed to a better understanding of their pathophysiology. Nonetheless, several questions and doubts persist. Recent studies have focused on environmental influences in the development of MDs, and the advent of neuroscientific methodologies has provided new perspectives. Early life events, such as childhood stress, may affect neurodevelopment through mechanisms such as gene-environment interactions and epigenetic regulation, thus leading to diseases in adulthood. The aim of this paper is to review the evidence regarding the role of the environment, particularly childhood stress, in the pathophysiology of MD. METHODOLOGY: We reviewed articles that evaluated environmental influences, with a particular focus on childhood trauma, brain morphology, cognitive functions, and the development of psychopathology and MD. RESULTS AND CONCLUSION: MRI studies have shown that exposure to trauma at an early age can result in several neurostructural changes, such as the reduction of the hippocampus and corpus callosum. Cognitive performance and functioning are also altered in this population. Finally, childhood stress is related to an increased risk of developing MD such as depression, bipolar disorder, schizophrenia and substance abuse. We conclude that there is robust evidence of the role of the environment, specifically adverse childhood experiences, in various aspects of MD.OBJETIVO: Avanços no conhecimento da genética dos transtornos mentais (TM contribuíram para um melhor entendimento de suas bases fisiopatológicas. No entanto, dúvidas e questões ainda persistem. Estudos recentes têm se concentrado nas influências do ambiente no desenvolvimento de TM, e o advento de metodologias neurocientíficas oferece novas perspectivas. Eventos precoces de vida, como estresse na infância, podem ser capazes de alterar o neurodesenvolvimento através de mecanismos como intera

  15. Measurement of direct CP-violation with the experiments NA31 and NA48 at CERN

    International Nuclear Information System (INIS)

    Renk, B.

    1992-01-01

    The NA31 experiment has measured the CP violation parameter var-epsilon '/var-epsilon. The result of data collected in 1988 is Re(var-epsilon '/var-epsilon)=(1.7±1.0)x10 -3 . A preliminary result of data collected in 1989 is Re(var-epsilon '/var-epsilon)=(2.1±0.9)x10 -3 . Combining these two results with the original result from the 1986 data set we obtain Re(var-epsilon '/var-epsilon)=(2.3±0.7)x10 -3 , which is a more than three standard deviation evidence for direct CP violation. A new experiment NA48 is under construction which aims for a significant reduction of the statistical and the systematical errors in order to reach a combined error not exceeding 2x10 -4

  16. O Platonismo de Russell na metafísica e na matemática

    Directory of Open Access Journals (Sweden)

    Guido Imaguire

    2005-06-01

    Full Text Available Neste artigo, analiso o surgimento e a superação do Platonismo em B. Russell, tanto na sua filosofia da matemática como na sua metafísica. Começo por explicitar os argumentos que levaram Russell a aderir ao chamado "Platonismo Proposicional" - posição que será tecnicamente relevante na definição de números. Na seção seguinte, discutirei até que ponto a teoria das descrições definidas determina, necessariamente, uma adesão ao nominalismo, e as dificuldades que surgem para o logicismo conseqüentes do abandono do platonismo. Finalmente, mostrarei como a posição madura de Russell caracteriza-se mais como um reducionismo do que propriamente como um nominalismo, e como este é fundado no princípio do mínimo vocabulário.In this paper, I analyze the emergence and the overcoming of Platonism both in Russell's philosophy of mathematics and his metaphysics. I begin by examining the arguments which led Russell to endorse a position that I term "Propositional Platonism" - this position proves to be relevant for Russell's definition of numbers. In the following section, I address the question of the extent to which Russell's theory of descriptions implies the acceptance of nominalism. Moreover, I examine the difficulties which arise for logicism, if it no longer goes hand in hand with platonism. Finally, I argue argue that Russell's mature position is to be characterized as a form of reductionism rather than as a variant of nominalism

  17. LASERTERAPIA NA INFLAMAÇÃO PULMONAR EXPERIMENTAL EM RATTUS NORVEGICUS OCASIONADO PELA PAPAÍNA

    Directory of Open Access Journals (Sweden)

    Diego Rodrigues Pessoa

    2017-01-01

    Full Text Available Resumo: A Doença Pulmonar Obstrutiva Crônica (DPOC é caracterizada pela limitação do fluxo aéreo decorrente da dilatação dos espaços aéreos distais aos bronquíolos terminais. Analisar os efeitos da laserterapia quanto ao processo cicatricial na lesão pulmonar experimental em Rattus Novergicus. Utilizaram-se trinta animais agrupados em três grupos de dez animais: grupo controle (GC (não recebeu nada, grupo DPOC (GD (foi pulverizado 3 doses de papaína 3mg/kg e grupo DPOC + Laser (GDL (após 7 dias da indução da lesão com papaína foi tratado com laser de 660 nm durante 15 dias.Para analise dos resultados foi realizado o lavado broncoalveolar. Quanto ao Lavado: GC (número de células normais, GD (aumento de células inflamatórias e GDL (diminuição de células inflamatórias. A laserterapia diminui o numero de células inflamatórias, entretanto, não possui efeito reconstrutor do parênquima pulmonar apenas estabiliza a lesão comprovando sua ação anti-inflamatória.

  18. Isolation and preliminary function analysis of a Na + /H + antiporter ...

    African Journals Online (AJOL)

    A full-length cDNA Na+/H+ antiporter gene (MzNHX1) was isolated from Malus zumi according to the homologous Na+/H+ antiporter gene region in plants. Sequence analysis indicated that the cDNA was 2062 bp in length, including an open reading frame (ORF) of 1629 bp, which encoded a predicted polypeptide of 542 ...

  19. Transepithelial Na+ transport and the intracellular fluids: a computer study.

    Science.gov (United States)

    Civan, M M; Bookman, R J

    1982-01-01

    Computer simulations of tight epithelia under three experimental conditions have been carried out, using the rheogenic nonlinear model of Lew, Ferreira and Moura (Proc. Roy. Soc. London. B 206:53-83, 1979) based largely on the formulation of Koefoed-Johnsen and Ussing (Acta Physiol. Scand. 42: 298-308. 1958). First, analysis of the transition between the short-circuited and open-circuited states has indicated that (i) apical Cl- permeability is a critical parameter requiring experimental definition in order to analyze cell volume regulation, and (ii) contrary to certain experimental reports, intracellular Na+ concentration (ccNa) is expected to be a strong function of transepithelial clamping voltage. Second, analysis of the effects of lowering serosal K+ concentration (csK) indicates that the basic model cannot simulate several well-documented observations; these defects can be overcome, at least qualitatively, by modifying the model to take account of the negative feedback interaction likely to exist between the apical Na+ permeability and ccNa. Third, analysis of the strongly supports the concept that osmotically induced permeability changes in the apical intercellular junctions play a physiological role in conserving the body's stores of NaCl. The analyses also demonstrate that the importance of Na+ entry across the basolateral membrane is strongly dependent upon transepithelial potential, cmNa and csK; under certain conditions, net Na+ entry could be appreciably greater across the basolateral than across the apical membrane.

  20. A mudança organizacional na teoria administrativa

    OpenAIRE

    Silveira Júnior, Aldery; Oliveira, Waldyr Viegas de

    1996-01-01

    Discorre sobre a mudança organizacional na teoria administrativa, abordando a natureza da mudança, como ela se insere no contexto das organizações e como ela se desenvolveu na história da administração.

  1. High resolution laser spectroscopy of the D lines of on-line produced 21Na, 22Na, 24Na, 25Na using a new high sensitivity method of detection of optical resonances

    International Nuclear Information System (INIS)

    Huber, G.; Thibault, G.; Klapisch, R.; Duong, H.T.; Vialle, J.L.; Pinard, I.; Juncar, P.; Jacquinot, P.

    1975-01-01

    A polyisotopic sodium beam of 21 - 25 Na, produced by spallation of Al, was illuminated by a tunable dye laser. The atomic beam, analyzed by a sixpole magnet is then ionized and detected after a mass spectrometer. The results are the isotope shifts, nuclear magnetic moment and quadrupole moment of 25 Na [fr

  2. Numerična in eksperimentalna analiza delovanja Teslinega ventilatorja

    OpenAIRE

    Lukačič, Rajko

    2017-01-01

    Nikola Tesla je patentiral ventilator, ki deluje na principu trenja. V diplomskem delu je opisano delovanje Teslinega ventilatorja in teoretično ozadje njegovega delovanja z namenom zmanjševanja hrupa. V sami raziskavi smo s programom Ansys izdelali numerični model, ki temelji na turbulentnem modelu k-

  3. Risbjerg: SF vandt valgkampen, NA og R tabte

    DEFF Research Database (Denmark)

    Thomsen, Søren Risbjerg

    2007-01-01

    ANALYSE: Endnu engang flyttede en valgkamp for alvor stemmer. SF gik undervejs 27 pct. frem, mens NA gik 34 pct. tilbage og R 26 pct. Udgivelsesdato: 25. november......ANALYSE: Endnu engang flyttede en valgkamp for alvor stemmer. SF gik undervejs 27 pct. frem, mens NA gik 34 pct. tilbage og R 26 pct. Udgivelsesdato: 25. november...

  4. MCHANGO WA MWALIMU J.K. NYERERE KATIKA TAFSIRI NA ...

    African Journals Online (AJOL)

    Kwa kuzingatia tafsiri mbili za J.K. Nyerere, Julius Kaizer (1963) na Mabepari wa Venus (1969), makala inaeleza: (i) kwa nini Mwalimu Nyerere alitafsiri maandishi ya Shakespeare, (ii) ufanisi wa tafsiri zake, na (iii) mchango wa tafsiri hizo. Makala inaonyesha kuwa tafsiri hizo zinazingatia mbinu za kisemantiki zaidi kuliko ...

  5. Kuingiliana kwa Lugha ya Kiswahili na Kiingereza: Uswahilishaji wa ...

    African Journals Online (AJOL)

    Kuingiliana kwa lugha ni taaluma katika uwanja wa isimu inayohusu lugha zinazoingiliana na kuathiriana. Kuingiliana kwa lugha sio jambo jipya katika dunia. Watu ambao ndio watumiaji wa lugha wamesababisha lugha kuiingiliana waliposafiri au kuhama sehemu moja hadi nyingine kutokana na sababu za kiuchumi, ...

  6. Ufundishaji wa Kusoma na Kuandika Kiswahili: Uzoefu wa Idara ya ...

    African Journals Online (AJOL)

    Makala haya yanahusu shughuli za kufundisha Kiswahili kama lugha ya kigeni katika Chuo Kikuu cha Sebha nchini Libya. Kwanza inaeleza historia ya Kiswahili – yaani kilianza lini kufundishwa kwa madhumuni gani na nani walikuwa wanzilishi. Halikadhalika makala ya naeleza utaratibu uliowekwa na idara ili kuweza ...

  7. Juhudi za Vyombo vya Habari katika Kukuza na Kueneza Kiswahili ...

    African Journals Online (AJOL)

    Vyombo vya habari ni asasi muhimu sana katika kukuza na kueneza lugha yoyote ile, hasa katika enzi hii ya utandawazi. Vyombo hivyo ni kama vile idhaa za redio, televisheni na magazeti. Katika nchi ya Kenya kuna vyombo vya habari vinavyotoa huduma anuwai kwa ajili ya kutosheleza mahitaji ya wateja wao. Katika ...

  8. Substrate Specificity of Na+,Cl-(HCO3-)-ATPase.

    Science.gov (United States)

    Yurkiv, V A; Melikhov, V I; Shubin, V S

    2016-09-01

    We studied substrate specificity of Na + ,Cl - (HCO 3 - )-ATPase. In most cases, replacement of ATP for other phosphate-containing substances resulted in not only pronounced suppression of phosphohydrolase reactions, but also dramatic changes of their responsiveness to the stimulating effect of monovalent ions. The data showed that Na + ,Cl - (HCO 3 - )-ATPase is a highly specific enzyme for ATP.

  9. Optimization and kinetics decomposition of monazite using NaOH

    International Nuclear Information System (INIS)

    MV Purwani; Suyanti; Deddy Husnurrofiq

    2015-01-01

    Decomposition of monazite with NaOH has been done. Decomposition performed at high temperature on furnace. The parameters studied were the comparison NaOH / monazite, temperature and time decomposition. From the research decomposition for 100 grams of monazite with NaOH, it can be concluded that the greater the ratio of NaOH / monazite, the greater the conversion. In the temperature influences decomposition 400 - 700°C, the greater the reaction rate constant with increasing temperature greater decomposition. Comparison NaOH / monazite optimum was 1.5 and the optimum time of 3 hours. Relations ratio NaOH / monazite with conversion (x) following the polynomial equation y = 0.1579x 2 – 0.2855x + 0.8301 (y = conversion and x = ratio of NaOH/monazite). Decomposition reaction of monazite with NaOH was second orde reaction, the relationship between temperature (T) with a reaction rate constant (k), k = 6.106.e - 1006.8 /T or ln k = - 1006.8/T + 6.106, frequency factor A = 448.541, activation energy E = 8.371 kJ/mol. (author)

  10. Sepsis does not alter red blood cell glucose metabolism or Na+ concentration: A 2H-, 23Na-NMR study

    International Nuclear Information System (INIS)

    Hotchkiss, R.S.; Song, S.K.; Ling, C.S.; Ackerman, J.J.; Karl, I.E.

    1990-01-01

    The effects of sepsis on intracellular Na+ concentration ([Na+]i) and glucose metabolism were examined in rat red blood cells (RBCs) by using 23Na- and 2H-nuclear magnetic resonance (NMR) spectroscopy. Sepsis was induced in 15 halothane-anesthetized female Sprague-Dawley rats by using the cecal ligation and perforation technique; 14 control rats underwent cecal manipulation without ligation. The animals were fasted for 36 h, but allowed free access to water. At 36 h postsurgery, RBCs were examined by 23Na-NMR by using dysprosium tripolyphosphate as a chemical shift reagent. Human RBCs from 17 critically ill nonseptic patients and from 7 patients who were diagnosed as septic were also examined for [Na+]i. Five rat RBC specimens had [Na+]i determined by both 23Na-NMR and inductively coupled plasma-atomic emission spectroscopy (ICP-AES). For glucose metabolism studies, RBCs from septic and control rats were suspended in modified Krebs-Henseleit buffer containing [6,6-2H2]glucose and examined by 2H-NMR. No significant differences in [Na+]i or glucose utilization were found in RBCs from control or septic rats. There were no differences in [Na+]i in the two groups of patients. The [Na+]i determined by NMR spectroscopy agreed closely with measurements using ICP-AES and establish that 100% of the [Na+]i of the RBC is visible by NMR. Glucose measurements determined by 2H-NMR correlated closely (correlation coefficient = 0.93) with enzymatic analysis. These studies showed no evidence that sepsis disturbed RBC membrane function or metabolism

  11. Instrumental neutron-activation analysis applications in the age dynamics assessment of Ca, Cl, K, Mg. Mn, Na, P, and Sr contents in the human cortical bone

    International Nuclear Information System (INIS)

    Zaichick, V.

    2003-01-01

    Full text: Senile osteoporosis and particularly osteoporosis among postmenopausal women represents an urgent problem of modern medicine. One of the main osteoporosis symptoms is a decrease in both bone mineral density and subsequent bone strength. The upper extremity of the femur in humans is a particularly vulnerable section of the skeleton, being subject to fracture and necrosis and to destruction of its cartilage. Iliac crest biopsies are commonly taken clinically on patients. It is known that the control of the mineral component providing bone strength is a good indicator to detect bone diseases like osteoporosis. Despite this, changes of chemical element contents occurring with age in the femoral head and the iliac crest of female and male separately have been little studied, but in iliac cortical bone have not been studied at all. The effect of age and sex on chemical element contents in intact cortical bone of femoral neck and iliac crest of 81 relatively healthy 15-55 years old women (n=36) and men (n=45) was investigated. All subjects had died suddenly and bone samples were obtained at necropsy from the right side of bodies within twenty-four hours after death. A tool made of titanium and plastic was used to clear samples from soft tissues and blood and to cut cortical part of bone. The IAEA and NIST reference materials (H-5 animal bone and SRM1486 bone meal) were used to estimate the precision and accuracy of results. Contents of Ca, Cl, K, Mg> Mn, Na, P, and Sr in intact bone samples were determined by instrumental neutron activation analysis using short-lived radionuclides. Our means data for each element of reference materials were within the certified 95 % confidence interval, and indicate an acceptable accuracy of the obtained results. No age- and sex-related differences in the cortical femoral neck composition were detected. Mean values (M±S.E.M.) of Ca, Cl, K, Mg, Mn, Na, P, and Sr mass fractions (on dry weight basis) for female and male all

  12. Experiments on cold trap regeneration by NaH decomposition

    International Nuclear Information System (INIS)

    McPheeters, C.C.; Skladzien, S.B.; Raue, D.J.

    1979-10-01

    Cold trap regeneration may be very important in future LMFBRs because of the expected high hydrogen source from the steam generators. This hydrogen precipitates as NaH in the cold trap and may fill the trap within one year of operation. Several methods of cold trap regeneration were considered, but the simplest and least expensive appears to be decomposition of NaH under vacuum at elevated temperatures. Experiments were done to assess the feasibility of this method for cold trap regeneration. Small-scale simulated cold traps (SCT) were located with NaH and NaH plus Na 2 O, and were heated both under vacuum and under a sweep gas at 100 kPa. The evolved hydrogen was converted to water by a CuO bed and collected in a weighting tube

  13. Na,K-pump modulates intercellular communication in vascular wall

    DEFF Research Database (Denmark)

    Matchkov, Vladimir; Nilsson, Holger; Aalkjær, Christian

      Ouabain, a specific inhibitor of the Na,K-pump, has previously been shown to interfere with intercellular communication. Here we test the hypothesis that the communication between vascular smooth muscle cells (SMCs) is regulated through an interaction between the Na,K-pump and the Na...... were used as a model for electrical coupling of SMCs by measuring membrane capacitance (Cm). SMCs were uncoupled (evaluated by inhibition of vasomotion and desynchronization of calcium transients in vascular wall, or by reduction to half of Cm measured in paired A7r5 cells) when the Na,K-pump...... was inhibited either by a low concentration of ouabain or by ATP depletion. Uncoupling with ouabain was associated with a localized increase of intracellular calcium in discrete sites near the plasma membrane. Reduction of Na,K-pump activity by removal of extracellular potassium also uncoupled cells, but only...

  14. Recent results from the NA62 experiment at CERN

    CERN Document Server

    Aliberti, Riccardo

    2016-01-01

    NA62 is a fixed target experiment located at the CERN SPS which aims to perform flavour physics studies in the charged kaon sector with an unprecedented precision. Due to the abundance of kaon decays with a po in the final state, NA62 is also a perfect environment to measure the neutral pion characteristics. NA62 collected a large sample of charged kaon decays with a highly efficient trigger for decays into electrons in 2007. We report about the measurement of the po electromagnetic transition form factor slope parameter in the time-like region. Between 2008 and 2014 the NA62 apparatus underwent an intense upgrade phase to improve the physics sensitivity of the experiment to precisely measure the Br (K+ !p+n ¯ n). NA62 took data in pilot runs in 2014 and 2015 reaching the final designed beam intensity. The quality of data acquired in view of the final measurement is presented.

  15. The New Readout System of the NA62 LKr Calorimeter

    CERN Document Server

    Ceccucci, A; Farthouat, P; Lamanna, G; Rouet, J; Ryjov, V; Venditti, S

    2015-01-01

    The NA62 experiment [1] at CERN SPS (Super Proton Synchrotron) accelerator aims at studying Kaon decays with high precision. The high resolution Liquid Krypton (LKr) calorimeter, built for the NA48 [2] experiment, is a crucial part of the photon-veto system; to cope with the demanding NA62 re- quirements,itsback-endelectron icshadtobecompletelyrenewed. The new readout system is based on the Calorimeter REAdout Module (CREAM) [3], a 6U VME board whose design and pro- duction was sub-contracted to CAEN [4], with CERN NA62 group continuously supervising the de velopment and production phase. The first version of the board was delivered by the manufacturer in March 2013 and, as of June 2014, the full board production is ongoing. In addition to describing the CREAM board, all aspects of the new LKr readout system, including its integration within the NA62 TDAQ scheme, will be treated.

  16. Crystal Structure of Na3MoCl6

    Directory of Open Access Journals (Sweden)

    Martin Beran

    2011-07-01

    Full Text Available The ternary chloride Na3MoCl6 is obtained as red crystals from a disproportionation reaction of molybdenum dichloride, {Mo6}Cl12, in an acidic NaCl/AlCl3 melt at 350 °C. The crystal structure (trigonal, P-31c, a = 687.1(1, c = 1225.3(2 pm, Z = 2, V = 501,0(1 106 pm3 is that of Na3CrCl6: within a hexagonal closest-packing of chloride ions two thirds of the octahedral voids are filled between the AB double layers with Na+/Mo3+, and between the BA layers with Na+.

  17. Dynamic polarizabilities and Van der Waals coefficients for alkali atoms Li, Na and alkali dimer molecules Li2, Na2 and NaLi

    Science.gov (United States)

    Mérawa, M.; Dargelos, A.

    1998-07-01

    The present paper gives an account of investigations of the polarizability of the alkali atoms Li, Na, diatomics homonuclear and heteronuclear Li2, Na2 and NaLi at SCF (Self Consistent Field) level of approximation and at correlated level, using a time Time-Dependent Gauge Invariant method (TDGI). Our static polarizability values agree with the best experimental and theoretical determinations. The Van der Waals C6 coefficients for the atom-atom, atom-dimer and dimer-dimer interactions have been evaluated. Les polarisabilités des atomes alcalins Li, Na, et des molécules diatomiques homonucléaires et hétéronucléaire Li2, Na2 et NaLi, ont été calculées au niveau SCF (Self Consistent Field) et au niveau corrélé à partir d'une méthode invariante de jauge dépendante du temps(TDGI). Nos valeurs des polarisabilités statiques sont en accord avec les meilleurs déterminations expérimentales et théoriques. Les coefficients C6 de Van de Waals pour les interactions atome-atome, atome-dimère et dimère-dimère ont également été évalués.

  18. Fanfictions: leitura e escrita na cibercultura

    Directory of Open Access Journals (Sweden)

    Monica do Amparo Silva

    2017-12-01

    Full Text Available A condição letrada é um fenômeno de natureza complexa e multifacetada. Organiza-se em torno de um conjunto de gestos e comportamentos diversificados, de competências e habilidades heterogêneas, de objetos histórica e socialmente diferenciados; é construída por meio de um conjunto de práticas e de uma rede de instituições, agentes e materiais; responsável por grandes divisões no interior da sociedade e um dos fatores que poderiam transformá-la. O ingresso na cultura escrita por sociedades ocidentais já foi considerado uma das principais evoluções da era moderna. Dominar a escrita era também a produzir. Contemporaneamente, uma sociedade civilizada chega a exigir de seus membros o domínio e utilização da leitura de variados suportes em variadas formas (pois cada suporte acaba por desenvolver um modo de leitura peculiar. Pode-se, pois, inferir que o ato de ler é um ato de esforço e concentração que também exige reflexão. Dessa forma, a leitura assume o papel de um processo de disciplina intelectual, exigindo uma posição crítica daquele que é o leitor. Os ciberjovens não só consomem a leitura e toda produção midiática. Eles interagem com essa produção e realizam uma recriação cultural com identidade e público próprios denominada fanfiction cuja escrita pode ser divulgada em diferentes plataformas do ciberespaço sob diversos gêneros textuais. Este artigo é resultado da reflexão baseada na observação de um app que permite a escrita/ leitura e a divulgação dessa produção.

  19. Kusheh, na minem Fatu, en mi na koko farmer Hello, I am Fatu and I am a cocoa farmer

    NARCIS (Netherlands)

    Witteveen, L.M.; Goris, Margriet; Lie, R.; Ingram, V.J.

    2016-01-01

    This document reports on the development of a prototype Digital Farmer Field School (DFFS) called Kusheh, na minem Fatu, en mi na koko farmer (“Hello, I am Fatu and I am a cocoa farmer”). The DFFS provides an ICT-based alternative to traditional agricultural extension. More specifically, it offers a

  20. Rescue of Na+ and H+ binding in Na+,K+-ATPase M8 aspartate mutants by secondary mutation

    DEFF Research Database (Denmark)

    Holm, Rikke; Einholm, Anja P.; Andersen, Jens Peter

    A mutation replacing the aspartate in transmembrane segment M8 in the a3-isoform of Na,K-ATPase with asparagine has been found in patients with rapid-onset dystonia parkinsonism or alternating hemiplegia of childhood. This aspartate may be a critical Na+ coordinating residue, but the crystal......-isoforms of Na,K-ATPase, and much smaller effects were seen for other mutations to the M8 aspartate, which were less disruptive of Na+ binding than mutations to other residues related to Na+ site III. The D928 (rat a1 numbering) mutations strongly diminished the cooperativity of Na+ binding. Moreover the p......H optimum of Na,K-ATPase activity was left-shifted, again with D928N being most disruptive. The reduced affinity for activating Na+ and for inhibitory protons, caused by D928N and D928A mutations, could be rescued by introduction of an additional mutation of a glutamate located far away from D928....

  1. Thermodiffusive behaviour of NaCl and KCl aqueous solutions a model for the Na-K pump

    International Nuclear Information System (INIS)

    Gaeta, F.S.; Mita, D.G.; Perna, G.; Scala, G.

    1975-01-01

    In NaCl and KCl aqueous nonisothermal solutions K + inverts its sense of migration within the physiological concentration range; Na + behaves similarly at much lower concentrations. These findings are discussed in relation to solute induced modifications of water structure and of their influence on thermal diffusion. A possible evolutionary model of a thermodiffusive mechanism for the sodium potassium pump is also suggested

  2. Evaluation of {sup 23}Na(n,2n){sup 22}Na reaction cross-sections

    Energy Technology Data Exchange (ETDEWEB)

    Manokhin, V N [Institute of Physics and Power Engineering, Obninsk (Russian Federation)

    1997-06-01

    Using available experimental data and (n,2n) excitation function systematics {sup 23}Na(n,2n){sup 22}Na reaction cross-sections were evaluated for energies ranging from the reaction threshold to 20 MeV. (author). 21 refs, 1 fig., 2 tabs.

  3. Endurance testing with Li/Na electrolyte

    Energy Technology Data Exchange (ETDEWEB)

    Ong, E.T.; Remick, R.J.; Sishtla, C.I. [Institute of Gas Technology, Des Plaines, IL (United States)

    1996-12-31

    The Institute of Gas Technology (IGT), under subcontract to M-C Power Corporation under DOE funding, has been operating bench-scale fuel cells to investigate the performance and endurance issues of the Li/Na electrolyte because it offers higher ionic conductivity, higher exchange current densities, lower vapor pressures, and lower cathode dissolution rates than the Li/K electrolyte. These cells have continued to show higher performance and lower decay rates than the Li/K cells since the publication of our two previous papers in 1994. In this paper, test results of two long-term 100-cm{sup 2} bench scale cells are discussed. One cell operated continuously at 160 mA/cm{sup 2} for 17,000 hours with reference gases (60H{sub 2}/20CO{sub 2}/20H{sub 2}O fuel at 75% utilization and 30CO{sub 2}/70 air oxidant humidified at room temperature at 50% utilization). The other cell operated at 160 mA/cm{sup 2} for 6900 hours at 3 atm with system gases (64H{sub 2}/16CO{sub 2}/20H{sub 2}O at 75% utilization and an M-C Power system-defined oxidant at 40% utilization). Both cells have shown the highest performance and longest endurance among IGT cells operated to date.

  4. Haveria uma antropologia infantil na modernidade?

    Directory of Open Access Journals (Sweden)

    José Carlos Souza Araujo

    2009-12-01

    Full Text Available Buscando situar uma conceituação de Modernidade, que se expressa paulatinamente a partir do século XIII, a criança e a infância são situadas como um fenômeno central na constituição da cultura ocidental a partir de então. O objeto deste trabalho é configurar alguns marcos filosóficos em torno da criança a partir do século XVI, representados pelas concepções de Martinho Lutero, Erasmo de Roterdão, Juan Luis Vives, Michel de Montaigne, John Locke, João Amós Comênio, Jean-Jacques Rousseau, Immanuel Kant, Johann Heinrich Pestalozzi, Friedrich W. A. Froebel, Johann Friedrich Herbart, William James, John Dewey e Antonio Gramsci. Evidentemente, tais pensadores revelam posições múltiplas, por vezes antagônicas, expressas através de antropologias assentadas no inatismo, no naturalismo, no deísmo, no empirismo, no cristianismo, no racionalismo, no idealismo, no materialismo histórico, entre outras. Entretanto, a criança é sempre situada em tais posicionamentos como um projeto inerente à cultura, constituindo-se a educação e a pedagogia como instrumentos para a sua formação.

  5. Lugares dos mortos na cristandade ocidental

    Directory of Open Access Journals (Sweden)

    Cláudia Rodrigues

    2013-01-01

    Full Text Available Resumo. Este artigo busca refletir sobre a forte associação entre morte e cristandade no Ocidente, buscando identificar os lugares dos mortos nos diferentes sistemas de cristandade. Propõe-se aqui a viabilidade de se pensar numa certa vinculação entre determinadas atitudes e representações diante da morte e do morrer e o sistema de cristandade vigente em determinados contextos históricos, entre fins da Antiguidade tardia e o século XX, mais especificamente em países nos quais a Igreja romana exerceu hegemonia sobre a sociedade. Procura argumentar que, enquanto predominou a modalidade “constantiniana”, os mortos faziam parte do cotidiano e a morte e foram instrumentos do projeto cristianizador. Quando este modelo de Cristandade recuou, diante da emergência da chamada “Cristandade pós-constantiniana” – na qual a Igreja não mais era braço do aparelho estatal –, os mortos tinham sido afastados da cidade dos vivos e a morte, ou melhor, o medo da morte não mais representava instrumento de pressão sobre a consciência do cidadão

  6. Energy stored in irradiated NaCl

    International Nuclear Information System (INIS)

    Lidiard, A.B.

    1979-01-01

    Recently reported measurements of the energy stored in heavily irradiated NaCl are reviewed in the light of recent understanding of radiation-damage processes in this material. It is shown that, in the ranges of temperatures and dose rates of these experiments, the F-centres produced by the irradiation are retained principally in the form of colloids: the stored energy is thus a direct measure of the number of F-centres retained in this form. Comparison of these results with the prediction of the recently proposed theory of colloid growth shows that the predictions of the dependence of colloid growth rates upon temperature and dose rate are qualitatively correct. The dependence of stored energy dose, however, appears to require the inclusion of a thermally activated back-reaction and possible modifications to the theory are briefly discussed. However, further experiments in this range of temperatures and dose rates are necessary for more quantitative tests of the theory. This reconsideration of the data does not alter the broad conclusion as to the relative insignificance of stored energy in a natural salt formation used as a radioactive waste repository, although more extensive measurements permitting a more exact test of theory would allow better predictions to be made for such applications. (author)

  7. Absorto na ação

    Directory of Open Access Journals (Sweden)

    Michael Fried

    2010-07-01

    Full Text Available O filme Zidane, um retrato do século XXI, de Douglas Gordon e Philippe Parreno (2006 pertence à tradição de absorção que desempenhou um papel crucial na evolução da arte moderna. O autor explora a tensão entre absorção e teatralidade - central tanto para a pintura francesa do século XVIII como para a fotografia dos séculos XX e XXI - e tira conseqüências estéticas e filosóficas do filme que retrata, ao longo de todos os noventa minutos de uma partida de futebol, o meio-campista francês Zinedine Zidane.Zidane, a 21st Century Portrait, a film by Douglas Gordon and Philippe Perreno, belongs to the absorptive tradition that has played a central role in the evolution of modern art. The author explores the tension between absorption and theatricality - crucial to 18th century French art as well as to 20th and 21th century photography - and draws aesthetic and philosophical consequences of this film that depicts, throughout all the 90 minutes of a soccer match, the French midfielder Zinedine Zidane.

  8. A Música Tradicional Madeirense na Transitoriedade

    Directory of Open Access Journals (Sweden)

    Rodolfo Cró

    2011-09-01

    Full Text Available O presente artigo procura expor, de uma forma sucinta, um conjunto de temáticas pertinentes ao contexto da música tradicional madeirense no atual panorama. Tendo como pano de fundo todas as transformações nos campos sociais, económicos e culturais, a contemporaneidade musical equaciona uma nova atitude, ou seja, uma necessidade reflexiva e crítica, face a um conjunto de elementos pluridimensionais. Contudo, a discussão em torno da globalização 1, ou seja “[…] o mundo como «aldeia global» […]” (Appadurai, 1996: 45 e da regionalização 2, ou seja, os “[…] particularismos ou culturas locais […]” (Featherstone, 2001: 84, em termos musicais, terá dese revestir numa proporção de dois conceitos, em que uma cultura conservadora dará lugar a uma cultura híbrida, no sentidoda modernidade. Tendo em conta que a evolução em princípio só se faz com programas culturais de renovação, experimentação e crítica (Canclini, 1992, é neste contexto que surgem as novas tecnologias; em concreto o software musical na sala de aula. Neste sentido, este artigo vem propor uma reflexão e um debate à luz de uma perspetiva cultural.

  9. Status for 2015, CERN NA63

    CERN Document Server

    Mikkelsen, RE; Wistisen, T

    2015-01-01

    We summarize the status for the CERN NA63 collaboration, where in 2015 we have had two runs at the CERN SPS, beamline H4: One with Ar ions at various energies around 75 GeV per nucleon, and one with electrons/positrons of 10-20 GeV. We previously refined and updated our theoretical analyses of bremsstrahlung and delta-electron emission from heavy, and medium-heavy, ultrarelativistic nuclei \\cite{Mikk15}. We thus concluded that - although not quite as interesting as for Pb projectiles - projectiles of Ar and/or Xe were suitable for the investigation, and for establishing the method to eventually measure the charge distribution of short-lived ($ct\\gtrsim3$m) fragments \\cite{Mikk14}. However, as the preliminary data analysis shows, the signal - which requires an intact projectile - is about three orders of magnitude lower than the background, stemming from photon emission (possibly originating from $\\pi^0$'s) in coincidence with projectiles that most likely are not intact after the collision. With the presently ...

  10. Artesanato na terceira idade: um estudo na cidade de Sinop no ano de 2011

    Directory of Open Access Journals (Sweden)

    Rosane Marlene Weber

    2015-04-01

    Full Text Available Essa pesquisa tem como objetivo mostrar a importância do artesanato na Terceira Idade como atividade educacional e de autonomia para os idosos. Por existir uma preocupação com a qualidade de vida da Terceira Idade e sua autonomia, nesta fase que muitos acabam ficando dependentes dos membros da família, espera-se encontrar através da arte uma motivação e uma forma de demonstrar a autoria por meio do fazer, criar e recriar com o artesanato. Aprender e ensinar são um processo contínuo na vida do ser humano, independente da idade, para Paulo Freire precisamos ter consciência de que somos inacabados, e sendo conscientes de nossa inconclusão, devemos viver num permanente movimento de busca. Essa é uma das causas pelas quais será pesquisada a prática formativa/educacional por meio do artesanato na Terceira Idade. Os motivos que levaram a escolha desta pesquisa com o artesanato na Terceira Idade é o fato de ter vivido uma experiência de trabalho na ala geriátrica de um hospital. Já o artesanato é a arte que fascina, e acreditamos que sempre há tempo para recomeçar, para descobrir algo que possa trazer qualidade para nossa vida. Devido ao crescimento cada vez maior da expectativa de vida em nosso país, cria-se uma preocupação com a qualidade de vida das pessoas da Terceira Idade. Em relação aos aspectos educacionais e culturais, esta pesquisa deseja compreender como o artesanato pode trazer motivação para as pessoas da Terceira Idade como forma de autoria e autonomia, nesta fase da vida, na cidade de Sinop, e quais os motivos que os levam a realizar esse tipo de atividade. Para investigação teórica desta pesquisa do Artesanato na Terceira Idade: um estudo na cidade de Sinop em 2011 usaremos bibliografia de vários autores, mas em especial os que dedicam seus estudos a esta faixa etária, como a coleção de Vivaidade, que tem como organizadora principal Anita Liberalesso Neri. Os autores desta coleção nos trazem a reflex

  11. Synthesis of Ag or Pt Nanoparticles by Hydrolysis of Either Ag2Na or PtNa

    Directory of Open Access Journals (Sweden)

    Huabin Wang

    2008-01-01

    Full Text Available Ag and Pt nanoparticles have successfully been synthesized by hydrolysis of either Ag2Na or PtNa at room temperature. The oxidation of sodium in the Pt-Na pellets was much faster than that in the Ag-Na pellets since Pt is a catalyst for H2O formation reaction from hydrogen and oxygen at room temperature. The hydrolysis byproduct, NaOH, has a high solubility and easily is removed. This method offers a simple method of preparing transition metal nanoparticles. The Ag and Pt nanoparticles prepared by this method were crystalline in nature, and spherical in shape with a mean size of around 10 nm.

  12. Characterization and antibacterial activity of silver exchanged regenerated NaY zeolite from surfactant-modified NaY zeolite

    Energy Technology Data Exchange (ETDEWEB)

    Salim, Mashitah Mad; Malek, Nik Ahmad Nizam Nik, E-mail: niknizam@fbb.utm.my

    2016-02-01

    The antibacterial activity of regenerated NaY zeolite (thermal treatment from cetyltrimethyl ammonium bromide (CTAB)-modified NaY zeolite and pretreatment with Na ions) loaded with silver ions were examined using the broth dilution minimum inhibitory concentration (MIC) method against Escherichia coli (E. coli ATCC 11229) and Staphylococcus aureus (S. aureus ATCC 6538). X-ray diffraction (XRD), attenuated total reflectance–Fourier transform infrared (ATR–FTIR) spectroscopy, field emission scanning electron microscopy (FESEM), energy dispersive X-ray (EDX) and chemical elemental analyses were used to characterize the regenerated NaY and AgY zeolites. The XRD patterns indicated that the calcination and addition of silver ions on regenerated NaY zeolite did not affect the structure of the regenerated NaY zeolite as the characteristic peaks of the NaY zeolite were retained, and no new peaks were observed. The regenerated AgY zeolite showed good antibacterial activity against both bacteria strains in distilled water, and the antibacterial activity of the samples increased with increasing Ag loaded on the regenerated AgY zeolite; the regenerated AgY zeolite was more effective against E. coli than S. aureus. However, the antibacterial activity of the regenerated AgY was not effective in saline solution for both bacteria. The study showed that CTAB-modified NaY zeolite materials could be regenerated to NaY zeolite using thermal treatment (550 °C, 5 h) and this material has excellent performance as an antibacterial agent after silver ions loading. - Highlights: • Thermal treatment was used to regenerate surfactant modified zeolite. • The regenerated NaY zeolite formed was added with different silver loadings. • Regenerated AgY zeolite was tested for antibacterial activity on E. coli and S. aureus. • The antibacterial activity increased with increased of the amount of silver loadings. • The zeolite structure did not change with thermal and modification

  13. Characterization and antibacterial activity of silver exchanged regenerated NaY zeolite from surfactant-modified NaY zeolite

    International Nuclear Information System (INIS)

    Salim, Mashitah Mad; Malek, Nik Ahmad Nizam Nik

    2016-01-01

    The antibacterial activity of regenerated NaY zeolite (thermal treatment from cetyltrimethyl ammonium bromide (CTAB)-modified NaY zeolite and pretreatment with Na ions) loaded with silver ions were examined using the broth dilution minimum inhibitory concentration (MIC) method against Escherichia coli (E. coli ATCC 11229) and Staphylococcus aureus (S. aureus ATCC 6538). X-ray diffraction (XRD), attenuated total reflectance–Fourier transform infrared (ATR–FTIR) spectroscopy, field emission scanning electron microscopy (FESEM), energy dispersive X-ray (EDX) and chemical elemental analyses were used to characterize the regenerated NaY and AgY zeolites. The XRD patterns indicated that the calcination and addition of silver ions on regenerated NaY zeolite did not affect the structure of the regenerated NaY zeolite as the characteristic peaks of the NaY zeolite were retained, and no new peaks were observed. The regenerated AgY zeolite showed good antibacterial activity against both bacteria strains in distilled water, and the antibacterial activity of the samples increased with increasing Ag loaded on the regenerated AgY zeolite; the regenerated AgY zeolite was more effective against E. coli than S. aureus. However, the antibacterial activity of the regenerated AgY was not effective in saline solution for both bacteria. The study showed that CTAB-modified NaY zeolite materials could be regenerated to NaY zeolite using thermal treatment (550 °C, 5 h) and this material has excellent performance as an antibacterial agent after silver ions loading. - Highlights: • Thermal treatment was used to regenerate surfactant modified zeolite. • The regenerated NaY zeolite formed was added with different silver loadings. • Regenerated AgY zeolite was tested for antibacterial activity on E. coli and S. aureus. • The antibacterial activity increased with increased of the amount of silver loadings. • The zeolite structure did not change with thermal and modification

  14. Rigidification of the autolysis loop enhances Na(+) binding to thrombin.

    Science.gov (United States)

    Pozzi, Nicola; Chen, Raymond; Chen, Zhiwei; Bah, Alaji; Di Cera, Enrico

    2011-11-01

    Binding of Na(+) to thrombin ensures high activity toward physiological substrates and optimizes the procoagulant and prothrombotic roles of the enzyme in vivo. Under physiological conditions of pH and temperature, the binding affinity of Na(+) is weak due to large heat capacity and enthalpy changes associated with binding, and the K(d)=80 mM ensures only 64% saturation of the site at the concentration of Na(+) in the blood (140 mM). Residues controlling Na(+) binding and activation have been identified. Yet, attempts to improve the interaction of Na(+) with thrombin and possibly increase catalytic activity under physiological conditions have so far been unsuccessful. Here we report how replacement of the flexible autolysis loop of human thrombin with the homologous rigid domain of the murine enzyme results in a drastic (up to 10-fold) increase in Na(+) affinity and a significant improvement in the catalytic activity of the enzyme. Rigidification of the autolysis loop abolishes the heat capacity change associated with Na(+) binding observed in the wild-type and also increases the stability of thrombin. These findings have general relevance to protein engineering studies of clotting proteases and trypsin-like enzymes. Copyright © 2011 Elsevier B.V. All rights reserved.

  15. Rigidification of the autolysis loop enhances Na+ binding to thrombin

    Science.gov (United States)

    Pozzi, Nicola; Chen, Raymond; Chen, Zhiwei; Bah, Alaji; Di Cera, Enrico

    2011-01-01

    Binding of Na+ to thrombin ensures high activity toward physiological substrates and optimizes the procoagulant and prothrombotic roles of the enzyme in vivo. Under physiological conditions of pH and temperature, the binding affinity of Na+ is weak due to large heat capacity and enthalpy changes associated with binding, and the Kd=80 mM ensures only 64% saturation of the site at the concentration of Na+ in the blood (140 mM). Residues controlling Na+ binding and activation have been identified. Yet, attempts to improve the interaction of Na+ with thrombin and possibly increase catalytic activity under physiological conditions have so far been unsuccessful. Here we report how replacement of the flexible autolysis loop of human thrombin with the homologous rigid domain of the murine enzyme results in a drastic (up to 10-fold) increase in Na+ affinity and a significant improvement in the catalytic activity of the enzyme. Rigidification of the autolysis loop abolishes the heat capacity change associated with Na+ binding observed in the wild-type and also increases the stability of thrombin. These findings have general relevance to protein engineering studies of clotting proteases and trypsin-like enzymes. PMID:21536369

  16. Hormonal regulation of Na -K -ATPase in cultured epithelial cells

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, J.P.; Jones, D.; Wiesmann, W.P.

    1986-08-01

    Aldosterone and insulin stimulate Na transport through mechanisms involving protein synthesis. Na -K -ATPase has been implicated in the action of both hormones. The authors examined the effect of aldosterone and insulin on Na -K -ATPase in epithelial cells in culture derived from toad urinary bladder (TB6C) and toad kidney (A6). Aldosterone, but not insulin, increases short-circuit current (I/sub sc/) in TB6C cells. Aldosterone increases Na -K -(TSP)ATPase activity after 18 h of incubation, but no effect can be seen at 3 and 6 h. Amiloride, which inhibits aldosterone-induced increases in I/sub sc/, has no effect on either basal or aldosterone stimulated enzyme activity. Both aldosterone and insulin increase I/sub sc/ in A6 cells and when added together are synergistic. Aldosterone stimulates enzyme activity in A6 cells, but insulin alone has no effect. However, aldosterone and insulin together stimulate enzyme activity more than aldosterone alone. It appears that stimulation of Na -K -ATPase activity is involved in aldosterone action in both cell lines but does not appear to be due to increased Na entry, since enhanced enzyme activity is not inhibited by amiloride. In contrast, insulin alone has no direct effect on Na -K -ATPase, although the increased enzyme activity following both agents in combination may explain their synergism on I/sub sc/.

  17. NaIrO3-A pentavalent post-perovskite

    International Nuclear Information System (INIS)

    Bremholm, M.; Dutton, S.E.; Stephens, P.W.; Cava, R.J.

    2011-01-01

    Sodium iridium (V) oxide, NaIrO 3, was synthesized by a high pressure solid state method and recovered to ambient conditions. It is found to be isostructural with CaIrO 3 , the much-studied structural analog of the high-pressure post-perovskite phase of MgSiO 3 . Among the oxide post-perovskites, NaIrO 3 is the first example with a pentavalent cation. The structure consists of layers of corner- and edge-sharing IrO 6 octahedra separated by layers of NaO 8 bicapped trigonal prisms. NaIrO 3 shows no magnetic ordering and resistivity measurements show non-metallic behavior. The crystal structure, electrical and magnetic properties are discussed and compared to known post-perovskites and pentavalent perovskite metal oxides. -- Graphical abstract: Sodium iridium(V) oxide, NaIrO 3 , synthesized by a high pressure solid state method and recovered to ambient conditions is found to crystallize as the post-perovskite structure and is the first example of a pentavalent ABO 3 post-perovskite. Research highlights: → NaIrO 3 post-perovskite stabilized by pressure. → First example of a pentavalent oxide post-perovskite. → Non-metallic and non-magnetic behavior of NaIrO 3 .

  18. As valsas na Europa e na América do Sul

    OpenAIRE

    Almeida, Hélder António Moreira de

    2014-01-01

    Dissertação apresentado à Escola Superior de Artes Aplicadas do Instituto Politécnico de Castelo Branco para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Performance. O objetivo deste trabalho é mostrar a história da valsa, a sua origem e influência de países da Europa Ocidental para a Europa do Sul como também a sua exportação Transatlântica para a América do sul. Pretendemos assim, mostrar o interesse destes compositores, na escrita desta forma mu...

  19. Search for dark photons in $\\pi^0$ decays at NA48 and NA62

    CERN Document Server

    Gonnella, Francesco

    2016-01-01

    The NA48/2 experiment at CERN collected, between 2003 and 2004, $1.69 \\times 10^{7}$ fully reconstructed $\\pi^{0} \\to \\gamma e^{+}e^{-}$ in the kinematic range $m_{ee}$ > 10 MeV/$c^{2}$, with a negligible background contamination. The sample is analysed to search for the presence of dark photons (${A}'$) via the decay chain $\\pi^{0} \\to \\gamma{A}', {A}' \\to e^{+}e^{-}$. No signal has been observed, and the exclusion limits on space of the dark photon mass $m_{{A}'}$ and the mixing parameter $e^{2}$ are reported.

  20. Electron scattering in graphene with adsorbed NaCl nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Drabińska, Aneta, E-mail: Aneta.Drabinska@fuw.edu.pl; Kaźmierczak, Piotr; Bożek, Rafał; Karpierz, Ewelina; Wysmołek, Andrzej; Kamińska, Maria [Faculty of Physics, University of Warsaw, Pasteura 5, 02-093 Warsaw (Poland); Wołoś, Agnieszka [Faculty of Physics, University of Warsaw, Pasteura 5, 02-093 Warsaw (Poland); Institute of Physics, Polish Academy of Sciences, Al. Lotników 32/46, 02-668 Warsaw (Poland); Pasternak, Iwona; Strupiński, Włodek [Institute of Electronic Materials Technology, Wólczyńska 133, 01-919 Warsaw (Poland); Krajewska, Aleksandra [Institute of Electronic Materials Technology, Wólczyńska 133, 01-919 Warsaw (Poland); Institute of Optoelectronics, Military University of Technology, Kaliskiego 2, 00-908 Warsaw (Poland)

    2015-01-07

    In this work, the results of contactless magnetoconductance and Raman spectroscopy measurements performed for a graphene sample after its immersion in NaCl solution were presented. The properties of the immersed sample were compared with those of a non-immersed reference sample. Atomic force microscopy and electron spin resonance experiments confirmed the deposition of NaCl nanoparticles on the graphene surface. A weak localization signal observed using contactless magnetoconductance showed the reduction of the coherence length after NaCl treatment of graphene. Temperature dependence of the coherence length indicated a change from ballistic to diffusive regime in electron transport after NaCl treatment. The main inelastic scattering process was of the electron-electron type but the major reason for the reduction of the coherence length at low temperatures was additional, temperature independent, inelastic scattering. We associate it with spin flip scattering, caused by NaCl nanoparticles present on the graphene surface. Raman spectroscopy showed an increase in the D and D′ bands intensities for graphene after its immersion in NaCl solution. An analysis of the D, D′, and G bands intensities proved that this additional scattering is related to the decoration of vacancies and grain boundaries with NaCl nanoparticles, as well as generation of new on-site defects as a result of the decoration of the graphene surface with NaCl nanoparticles. The observed energy shifts of 2D and G bands indicated that NaCl deposition on the graphene surface did not change carrier concentration, but reduced compressive biaxial strain in the graphene layer.