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Sample records for na retinosquise senil

  1. Retinosquise juvenil ligada ao X

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    Cesar Gomes da Silveira

    2015-08-01

    Full Text Available RESUMO Relatar o caso de um paciente masculino de 28 anos que foi encaminhado ao Centro de Estudos e Pesquisas Oculistas Associados (RJ para avaliação de retina e apresentou os achados típicos de retinosquise juvenil ligada ao cromossomo X: maculopatia cistóide com formação de cistos na fóvea e retinosquise periférica. Foi realizado o manejo conservador, com atenção para as complicações.

  2. The senile kidney

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    Denisova Т.Р.

    2015-03-01

    Full Text Available The given work summarizes external data and self-obtained results on development and diagnostic of kidney involution modifications. Article discusses definition of "senile kidney" as a clinical and pathomorphological term. Major statements on pathophysiological causes of age-associated renal disorders and their prognosis, specifics of chronic kidney disease in elderly and senile patients have been reviewed. Phenomenon of renal "multimorbidity" in eldely maximizes worsening risk of unmodifiable kidney function.

  3. Use of topical dorzolamide for patients with X-linked juvenile retinoschisis: case report Uso da dorzolamida tópica em pacientes com retinosquise juvenil ligada ao X: relato de caso

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    André Luís Carvalho de Moura Bastos

    2008-04-01

    Full Text Available X-linked juvenile retinoschisis (XLRS is a recessively inherited vitreoretinal degeneration characterized by macular pathology and splitting of the neuroretinal layers that is associated with alterations in the XLRS1 gene. There have been no therapeutic interventions known to be effective for patients with X-linked juvenile retinoschisis, but some studies are trying to determine the importance of dorzolamide for the treatment of foveal lesions in this disease. The authors, using optical coherence tomography, describe findings in a patient with X-linked juvenile retinoschisis, before and after a topical use of dorzolamide. Besides the improvement in his visual acuity, further studies are required to elucidate the real prevalence of nonresponse to dorzolamide and the frequency with which there may be a recurrence of foveal cystic changes during continued treatment.A retinosquise juvenil ligada ao X (XLRS é uma degeneração vítreo-retiniana hereditária e recessiva caracterizada por lesão macular e delaminação das camadas de fibras nervosas da retina, que está associada com alterações no gene XLRS1. Nenhuma intervenção terapêutica tem se mostrado efetiva em pacientes com retinosquise juvenil ligada ao X, mas alguns estudos estão tentando determinar a importância da dorzola mida no tratamento das lesões foveais desta doença. Os autores, usando a tomografia de coerência óptica, descrevem os achados em um paciente com retinosquise juvenil ligada ao X, antes e após o uso de dorzolamida tópica. Apesar da melhora na acuidade visual do paciente estudado, outros estudos são necessários para uma melhor elucidação da real prevalência dos pacientes não responsivos ao tratamento com dorzolamida, bem com a recorrência das lesões císticas a longo prazo.

  4. Eficácia de um regime de administração de antibióticos tópicos na redução da microbiota conjuntival de pacientes sadios com catarata senil The efficacy of topical antibiotics in reducing conjunctival microbiota of healthy patients with senile cataract

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    Renato Corrêa Souza de Oliveira

    2007-08-01

    Full Text Available OBJETIVOS: Identificar as bactérias que compõem a microbiota conjuntival de pacientes sadios com catarata senil, a susceptibilidade delas aos antibióticos testados e a eficácia de um regime de administração de antibióticos tópicos na redução dessa microbiota. MÉTODOS: Coorte prospectiva, não-randomizada, de 40 olhos de 40 pacientes divididos em 4 grupos de 10 pacientes cada, que utilizaram diferentes antibióticos tópicos (tobramicina, ciprofloxacino e gatifloxacino. Foram realizadas culturas de material conjuntival antes do uso dos medicamentos e 15, 30 e 60 minutos após o uso dos mesmos. Foram realizados testes de resistência bacteriana das bactérias isoladas e comparação da redução do crescimento bacteriano pela análise do número de unidade formadoras de colônias (UFC. RESULTADOS: Houve crescimento bacteriano em 92,5% dos pacientes. O estafilococo coagulase negativo foi a bactéria mais comumente encontrada (50% dos casos, seguido pelo Staphylococcus Aureus (23% e pelas bactérias gram negativas (26%. Das bactérias isoladas, 81,8% foram sensíveis a todos os antibióticos utilizados no estudo. Houve cinco casos de resistência ao ciprofloxacino e à tobramicina e dois de resistência ao gatifloxacino. Em todos os grupos houve diminuição do número de pacientes com cultura positiva em relação ao momento zero e em relação ao placebo. CONCLUSÃO: As bactérias gram-positivas, especialmente o estafilococo coagulase negativo, foram os microrganismos mais encontrados na conjuntiva normal dos pacientes estudados. As bactérias isoladas mostraram alta taxa de susceptibilidade aos antibióticos testados. O regime de uso desses antibióticos diminuiu o número de unidades formadoras de colônias em relação ao grupo controle, embora sem significância estatística na maioria dos casos.PURPOSE: To evaluate the conjunctival bacterial flora of healthy patients and its antibiotic resistance pattern and determine the effective

  5. Oral Ecchymosis in elderly: Senile purpura

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    Srikanth H Srivathsa

    2015-01-01

    Senile purpura is the clinical condition where purpuric spots and ecchymosis develop at the site of minimal injury. It occurs due to laxity of the connective tissue. Oral manifestation of this disease is rare and when one encounters such a case, proper examination with extensive differential diagnosis should be considered along with appropriate investigations. A case of senile purpura in an elderly patient who had developed oral ecchymosis secondary to denture injury is being reported.

  6. Occurrence of silent cerebral infarction in pre-senile, senile subjects with depressive states

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    Fujikawa, Tokumi; Yamawaki, Shigeto; Touhouda, Yoshikuni.

    1993-01-01

    We examined the relationship between pre-senile, senile depressive states and silent cerebral infarction (SCI) using magnetic resonance imaging (MRI). The diagnostic criteria of major depression according to DSM-3-R was used to diagnose. Patients in whom stroke had occurred or who had local neurologic symptoms were not included. About half of the patients with depressive states of pre-senile onset and most of the patients with those of senile onset had SCI, were considered to be organic-depressive states complicated with SCI. Because patients with depressive states with SCI are at high risk of occurrence of stroke, we designated this condition 'pre-stroke depression', and classified it with endogenous depression. At this time, it is important to begin therapy for cerebrovascular disease. (author)

  7. Differential alterations of cortical glutamatergic binding sites in senile dementia of the Alzheimer type

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    Chalmers, D.T.; Dewar, D.; Graham, D.I.; Brooks, D.N.; McCulloch, J.

    1990-01-01

    Involvement of cortical glutamatergic mechanisms in senile dementia of the Alzheimer type (SDAT) has been investigated with quantitative ligand-binding autoradiography. The distribution and density of Na(+)-dependent glutamate uptake sites and glutamate receptor subtypes--kainate, quisqualate, and N-methyl-D-aspartate--were measured in adjacent sections of frontal cortex obtained postmortem from six patients with SDAT and six age-matched controls. The number of senile plaques was determined in the same brain region. Binding of D-[3H]aspartate to Na(+)-dependent uptake sites was reduced by approximately 40% throughout SDAT frontal cortex relative to controls, indicating a general loss of glutamatergic presynaptic terminals. [3H]Kainate receptor binding was significantly increased by approximately 70% in deep layers of SDAT frontal cortex compared with controls, whereas this binding was unaltered in superficial laminae. There was a positive correlation (r = 0.914) between kainate binding and senile plaque number in deep cortical layers. Quisqualate receptors, as assessed by 2-amino-3-hydroxy-5-[3H]methylisoxazole-4-propionic acid binding, were unaltered in SDAT frontal cortex compared with controls. There was a small reduction (25%) in N-methyl-D-aspartate-sensitive [3H]glutamate binding only in superficial cortical layers of SDAT brains relative to control subjects. [3H]Glutamate binding in SDAT subjects was unrelated to senile plaque number in superficial cortical layers (r = 0.104). These results indicate that in the presence of cortical glutamatergic terminal loss in SDAT plastic alterations occur in some glutamate receptor subtypes but not in others

  8. Computed tomography in presenile, senile dementia

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    Tanabe, Norimitsu

    1981-01-01

    The author investigated the relations of brain atrophy demonstrated by computerized tomography, dementia and electroencephalogram (EEG) in presenile and senile diseases. The result revealed that the correlation of brain atrophy, when demonstrated on the basis of ventricular ratio, is more definite and higher with dementia than that when demonstrated on the ventricular width. It was also revealed that in the control group, the ventricle gets enlarged due to aging, but no such tendency was observed in the patient group. In the case of septugenarians, no significant difference was observed between the two, and the ventricular-brain ratio or the criteria of brain atrophy is 8 -- 9% in patients in their forties to fifties; 12% for those in their sixties, and more than 15% among those in their seventies. In the relation of the brain atrophy to EEG, it was revealed that EEG is closely related to dementia than is the ventricular ratio. Upon following the progress of patients with Alzheimer, it was found that dementia and brain atrophy do not progress parallel to each other, but in stages. (author)

  9. Senile dementia of the Alzheimer type.

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    Erwin, W G

    1984-01-01

    The etiology, pathophysiology, neurochemistry, diagnosis, clinical presentation, and management of senile dementia of the Alzheimer type (SDAT) are discussed. The etiology of SDAT is unclear. The pathophysiologic changes in the brain tissue of patients with SDAT are quantitative rather than qualitative in comparison to normal age-matched controls. The number of neuritic plaques and neurofibrillary tangles are positively correlated to the severity of clinical symptoms and cognitive impairment. There is overwhelming evidence that SDAT is associated with a loss of cholinergic function. Reduction of choline acetyltransferase activity, a cholinergic marker, has been significantly correlated to the severity of dementia. The diagnosis of SDAT is one of exclusion and is based upon clinical presentation and neurological, psychological, and laboratory testing. The clinical presentation of SDAT involves the progressive deterioration of intellectual capabilities. Management of SDAT primarily involves supportive care and symptom control. Attempts to treat the disease with cerebral vasodilators, metabolic enhancers, and neurotransmitter manipulation have been largely unsuccessful. Drug therapy aimed at reversing or retarding the progression of the disease is not recommended. Behavioral disturbances represent the main indication for drug use in patients with SDAT. The antipsychotic agents are considered the drugs of choice. SDAT remains an enigma. The successes in the treatment of the disease are few, but as more information is gathered on the neurochemical abnormalities involved, there is hope that early detection can prevent the disease or at least slow its progression.

  10. A statistical of chest measurements in normal senile Korean -difference of senile changes in cardiovascular system-

    International Nuclear Information System (INIS)

    Yoo, Myung Hee; Yim, Oak Soon; Yoo, Seong Yul; Rhee, Chung Sik; Kim, Hee Seop

    1980-01-01

    Various methods and availabilities of chest measurements in normal Korean adults and children have been studied by many investigators, but that in senile Korean have not been reported yet. The authors have measured of cardiovascular system in 370 cases of Chest PA view of normal senile Korean checked at Ewha Womans University Hospital from April 1978 to April 1980 and compared with normal Korean adult for the evaluation of difference between them. The results were as follow: 1. In cardiac measurement; Mean value of transverse diameter of heart was 13.46cm in male and 13.06cm in female, cardiothoracic ratio was 0.48 in male and 0.52 in female, long diameter of heart was 14.76cm in male and 14.02cm in female, and broad diameter of heart was 11.67cm in male and 11.08cm in female. 2. In aortic measurements; Mean value of width of ascending aorta was 2.78cm in male and 2.76cm in female, width of aortic knob was 3.88cm in male and 3.73cm in female, incidence of aorta reached the lower border of clavicle was 29.38% in male and 37.11% in female, length of ascending aorta was 9.30cm in male and 8.48cm in female, ratio of length of ascending aorta and right atrium was 1.15 in male and 1.16 in female, and calcification in aortic knob was 13.46% in male and 18.87% in female. 3. In pulmonary vessels; Mean value of diameter of right descending pulmonary artery was 1.49cm in male and 1.45cm in female, right hilar vascular distance was 4.34cm in male and 4.12cm in female, and left hilar vascular distance was 5.16cm in male and 5.01cm in female. 4. The results of comparison revealed significant morphological differences of senile cardiovascular system from younger adult group and obtained effective statistical measurements

  11. Metabolism and serum levels of tryptophan in senile cataract patients.

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    Costa, C; Angi, M R; De Carli, M; Vanzan, S; Allegri, G

    1982-03-30

    In order to clarify the role of tryptophan in the patogenesis of senile cataract, we have studied the serum total and free levels of tryptophan in cataract patients as compared with age and sex-matched controls, and the urinary excretion of 10 metabolites after oral load of the amino acid. This excretion increases in the cataract group both as total per cent and as kynurenine. No difference has been found in the free and total serum tryptophan between normal subjects and cataract patients. A possible role of the kynurenines in the pathogenesis of senile cataract is suggested.

  12. Computerized tomography of the brain in senile depression

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    Yoshimura, Yoshitaka

    1995-01-01

    Brain CT was performed on 33 senile depression patients. Sixteen healthy volunteers served as controls. The correlation between changes of brain CT findings and mental symtoms was also studied. The CT findings were assessed by visual, linear, and two-dimensional methods, and mental symptoms were assessed according to Hamilton's Psychiatric Rating Scale for Depression. Arophic changes were observed in the bilateral frontal lobe and left basal ganglia areas. The correlation between severity of atrophy and mental symptom profile of depression was suggested. Depression patients, especially with marked atrophy in the frontal lobe, were prone to be indifferent to their job and hobby, to depress psychomotor, and to show marked physical symptoms. The atrophic sites observed in depression patients were also common in dementia, suggesting the correlation between senile depression and dementia. (S.Y.)

  13. Computed tomography in patients with senile mental disorders

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    Sugai, Yuuichi; Nakayama, Hirosi; Tatemichi, Nobuhiro

    1987-01-01

    Computed tomography (CT) was employed to follow up 28 patients with senile mental disorders (52 to 84 years of age) over a period of one to six and a half years after the first presentation. The first CT scans showed ventricular enlargement in many instances, which made it difficult to distinguish functional from degenerative diseases. The yearly rate of ventricular enlargement was, therefore, obtained on sequential CT scannings. The yearly rate of ventricular enlargement was high, which was associated with progression of the disease in the group with Alzheimer's disease. In the group with functional diseases, however, ventricular enlargement and progression were independent of each other. Both the yearly rate of ventricular enlargement and mental function significantly correlated with decreased adaptation of daily life. Periodical CT scanning and clinical observation over a certain period may offer useful information on the differential diagnosis and prognosis of senile mental disorders. (Namekawa, K.)

  14. Thyroid tumours in the senile guppy, Lebistes reticulatus (Peters)

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    Woodhead, A.D.

    1979-01-01

    We have previously described a thyroid growth which had arisen spontaneously in a few senile fish from a laboratory population of guppies, Lebistes (Poecilia) reticulatus. We believed that this growth was neoplastic. Our histological interpretation has been questioned. In view of the problems in distinguishing between neoplastic an goitrous thyroid tissue in teleost fishes, we show photomicrographs of kidney and liver metastases from this tumor to support our earlier diagnosis.

  15. Exaggerated natri-calci-uresis and increased circulating levels of parathyroid hormone and 1,25-dihydroxyvitamin D in patients with senile hypertension.

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    Morimoto, S; Imaoka, M; Kitano, S; Imanaka, S; Fukuo, K; Miyashita, Y; Koh, E; Ogihara, T

    1991-01-01

    Renal handling of Na and Ca in response to physiological saline infusion (20 ml/kg i.v. for 2 h) was compared between 27 hypertensive (mean +/- SD age 79.8 +/- 9.2 years) and 44 normotensive (79.1 +/- 4.1 years) senile females. Compared to the normotensive group, the hypertensive group showed statistically significant decreases in the basal values of serum Ca and PRA, and significant increases in basal circulating levels of parathyroid hormone and 1,25(OH)2D and in urinary excretions of Na, Ca and Pi in the 2-hour urine specimens during the saline infusion. These results suggest that the excessive excretions of Ca and Pi associated with exaggerated natriuresis may participate in aberration of Ca metabolism in low-renin hypertensive seniles.

  16. Cataratas senil bilateral psicológico pre y posoperatorio Bilateral senile cataract: a pre- and postoperavitve psychological study

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    Armando Rodríguez Romero

    2003-12-01

    Full Text Available Se realizó un estudio psicológico comparativo en 50 pacientes con catarata senil bilateral antes y después de la operación, en el período comprendido de enero a diciembre de1999 según las variables de edad, escolaridad y estado civil. Predominó el grupo etáreo de 70 a 79 años, nivel escolar primario y estado civil casado. Los síntomas psicopatológicos y la distribución según trastornos psiquiátricos disminuyeron después de restablecida su visión una vez operados de cataratas, en los de ansiedad y tristeza de 42 a7 pacientes respectivamente.A psychological comparative study was conducted among 50 patients with senile bilareral cataract before and after the operation from January to December, 1999, according to the following variables: age, educational level and marital status. The age group 70-79, the elementary educational level and the married patients predominated. The psychopathological symptoms and the distribution according to psychiatric disorders decreased among those with anxiety and sadness from 42 to 7 patients, respectively, once they were operated on of cataract and their vision was reestablished.

  17. A survey of senile dementia in the high background radiation areas in Yangjiang, China

    International Nuclear Information System (INIS)

    Li Jia; Su Gasaki, H.; Yang Yuhua

    1997-01-01

    Objective: To evaluate the effects of long-term low dose and low dose-rate ionizing radiation exposure on the prevalence rate of senile dementia, further assess the effects of low-dose radiation exposure on central nervous system and study the pathogen of senile dementia, and provide direct observational data of human beings. Methods: A cross-sectional study of the prevalence of senile dementia was carried out in high background radiation areas in Yangjiang, Guangdong Province, China. The survey was conducted in two stages. For the initial screening, Hasegawa Dementia Scale (HDS) was used for all subjects. In the second stage, the stage of diagnosis, special questionnaires of healthy state of old people were sued. The final diagnoses were made according to the third revised edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM III-R) of American Psychiatric Association. Results: 1018 inhabitants aged 65 years and over, including 513 persons in HBRA and 505 in CA were observed. According to DSM III-R, 61 cases (31 cases in HBRA and 30 cases in CA) of senile dementia were diagnosed. The prevalence rates of senile dementia are 6.04% in HBRA and 5.94% in CA, the total prevalence rate being 5.99%. Conclusion: No significant statistical difference in the prevalence rate of senile dementia between the two areas was found, suggesting that the prevalence rate of senile dementia in these areas is not associated with the high background radiation exposure

  18. Proximal femoral nail antirotation versus hemiarthroplasty in the treatment of senile intertrochanteric fractures: Case report

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    Xiangping Luo

    2017-01-01

    Conclusions: These findings indicate that PFNA has obvious advantages over hemiarthroplasty in the treatment of senile intertrochanteric fractures. Hemiarthroplasty in treating these fractures is associated with greater surgical trauma and higher incidence of postoperative medical complications.

  19. Label-free brainwide visualization of senile plaque using cryo-micro-optical sectioning tomography.

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    Luo, Yilin; Wang, Anle; Liu, Mengmeng; Lei, Tian; Zhang, Xiaochuan; Gao, Zhaobing; Jiang, Hualiang; Gong, Hui; Yuan, Jing

    2017-11-01

    Optical visualization of pathological changes in Alzheimer's disease (AD) can facilitate exploration of disease mechanisms and treatments. However, existing optical imaging methods have limitations on mapping pathological evolution in the whole mouse brain. Previous research indicated endogenous fluorescence contrast of senile plaques. Therefore, we develop cryo-micro-optical sectioning tomography (cryo-MOST) to capture intrinsic fluorescence distribution of senile plaques at a micrometer-level resolution in the whole brain. Validation using immunofluorescence demonstrates the capacity of cryo-MOST to visualize and distinguish senile plaques with competent sensitivity and spatial resolution. Compared with imaging in room temperature, cryo-MOST provides better signal intensity and signal-to-noise ratio. Using cryo-MOST, we obtained whole-brain coronal distribution of senile plaques in a transgenic mouse without exogenous dye. Capable of label-free brainwide visualization of Alzheimer's pathology, cryo-MOST may be potentially useful for understanding neurodegenerative disease mechanisms and evaluating drug efficacy.

  20. Senile anorexia in different geriatric settings in Italy.

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    Donini, L M; Dominguez, L J; Barbagallo, M; Savina, C; Castellaneta, E; Cucinotta, D; Fiorito, A; Inelmen, E M; Sergi, G; Enzi, G; Cannella, C

    2011-11-01

    Anorexia is the most frequent modification of eating habits in old age, which may lead to malnutrition and consequent morbidity and mortality in older adults. We aimed to estimate the prevalence and factors associated to anorexia in a sample of Italian older persons living in different settings. Our secondary aim was to evaluate the impact of senile anorexia on nutritional status and on eating habits, as well as on functional status. Observational study in nursing homes, in rehabilitation and acute geriatric wards, and in the community in four Italian regions (Lazio, Sicily, Emilia-Romagna, and Veneto). 526 over 65 years old participants were recruited; 218 free-living subjects, 213 from nursing homes, and 96 patients from rehabilitation and acute geriatric wards in the context of a National Research Project (PRIN) from the Italian Ministry of Instruction, University and Research (2005-067913 "Cause e Prevalenza dell'Anoressia senile"). Anthropometric and nutritional evaluation, olfactory, chewing, and swallowing capacity, food preferences, cognitive function, functional status, depression, quality of life, social aspects, prescribed drugs, and evaluation of gastrointestinal symptoms and pain. Laboratory parameters included prealbumin, albumin, transferrin, C-reactive protein, mucoprotein, lymphocyte count, as well as neurotransmitters leptin, and ghrelin. Anorexia was considered as ≥50% reduction in food intake vs. a standard meal (using 3-day "Club Francophone de Gériatrie et Nutrition" form), in absence of oral disorders preventing mastication. The overall prevalence of anorexia was 21.2% with higher values among hospitalized patients (34.1% women and 27.2% men in long-term facilities; 33.3% women and 26.7% men in rehabilitation and geriatric wards; 3.3% women and 11.3% men living in the community) and in the oldest persons. Anorexic subjects were significantly less self-sufficient and presented more often a compromised nutritional and cognitive status. Diet

  1. [Esophageal wall structure in people of elderly and senile age].

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    aminova, G G; Grigorenko, D E; Sapin, M R; Mkhitarov, V A

    2014-01-01

    Using histological methods, the esophageal wall structure and the cytoarchitectonics of mucous membrane were studied in the individuals of elderly (n = 5) and senile (n = 10) age. The control group included the individuals of I (n = 3) and II (n = 3) periods of mature age. It was demonstrated that with advancing age in most cases the destructive processes took place in the epithelium (delamination of the layer, separation of large fragments, formation of microerosions etc.) in most of the studied cases. Lymphocytes, neutrophils and eosinophils were found between the epithelial cells; the numbers of infiltrating cells was increased 2-3 times during aging. Mucosal lamina propria and the submucosa, in particular, were characterized by the thickening of the bundles of collagen fibers. A two-fold increase in the number of the cells of the fibroblast lineage was found. The number of leukocytes in the lamina propria was increased by the eldery age in the upper and lower parts of the esophagus (3.5 and 1.75 times respectively). The changes in lamina muscularis were manifested by its thinning, delamination and myocyte dissociation. Remodeling of the muscular tunic was less pronounced. The degree of changes increased distally and varied widely depending on the individual peculiarities.

  2. Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum

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    Xia Hu

    2017-06-01

    Full Text Available Genetic variations in the vacuolar protein sorting 10 protein (Vps10p family have been linked to Alzheimer’s disease (AD. Here we demonstrate deposition of fragments from the Vps10p member sortilin at senile plaques (SPs in aged and AD human cerebrum. Sortilin changes were characterized in postmortem brains with antibodies against the extracellular and intracellular C-terminal domains. The two antibodies exhibited identical labeling in normal human cerebrum, occurring in the somata and dendrites of cortical and hippocampal neurons. The C-terminal antibody also marked extracellular lesions in some aged and all AD cases, appearing as isolated fibrils, mini-plaques, dense-packing or circular mature-looking plaques. Sortilin and β-amyloid (Aβ deposition were correlated overtly in a region/lamina- and case-dependent manner as analyzed in the temporal lobe structures, with co-localized immunofluorescence seen at individual SPs. However, sortilin deposition rarely occurred around the pia, at vascular wall or in areas with typical diffuse Aβ deposition, with the labeling not enhanced by section pretreatment with heating or formic acid. Levels of a major sortilin fragment ~15 kDa, predicted to derive from the C-terminal region, were dramatically elevated in AD relative to control cortical lysates. Thus, sortilin fragments are a prominent constituent of the extracellularly deposited protein products at SPs in human cerebrum.

  3. Effectiveness of a heparinoid-containing moisturiser to treat senile xerosis.

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    Hayama, Koremasa; Takano, Yusaku; Tamura, Jin; Tagami, Hachiro; Terui, Tadashi

    2015-02-01

    With the increasing elderly population in Japan, skin problems have become a greater concern. A heparinoid-containing moisturiser is frequently used in Japan, but there is a lack of evidence for its efficacy in treating senile xerosis. To determine whether there is a correlation between age and the hydration state of the stratum corneum (SC) assessed by skin capacitance, and to evaluate the efficiency of a heparinoid-containing moisturiser and a bed bath to treat senile xerosis. We recruited 73 individuals to assess the hydration state of the SC on their flexor forearm by measuring their skin capacitance. To evaluate the efficacy of a heparinoid-containing moisturiser on senile xerosis, we recruited seven inpatients with an inactive daily life (IDL) who had senile xerosis. They were treated with the moisturiser in addition to a bed bath in two different protocols, and we measured the skin capacitance on their flexor forearms on days 0, 7 and 14. There was a weak negative correlation (-0.3854, P capacitance and age. Following the moisturiser treatments, the seven inpatients had increased hydration of both arms on days 7 and 14. The skin capacitance of the right forearm slightly decreased on day 14, even though it was significantly different from day 0 (P < 0.05). These findings indicate that treatment with a heparinoid-containing moisturiser together with a bed bath is an effective method for treating patients who have senile xerosis and IDL. © 2014 The Australasian College of Dermatologists.

  4. Diagnosis related group grouping study of senile cataract patients based on E-CHAID algorithm

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    Ai-Jing Luo

    2018-02-01

    Full Text Available AIM: To figure out the contributed factors of the hospitalization expenses of senile cataract patients (HECP and build up an area-specified senile cataract diagnosis related group (DRG of Shanghai thereby formulating the reference range of HECP and providing scientific basis for the fair use and supervision of the health care insurance fund. METHODS: The data was collected from the first page of the medical records of 22 097 hospitalized patients from tertiary hospitals in Shanghai from 2010 to 2012 whose major diagnosis were senile cataract. Firstly, we analyzed the influence factors of HECP using univariate and multivariate analysis. DRG grouping was conducted according to the exhaustive Chi-squared automatic interaction detector (E-CHAID model, using HECP as target variable. Finally we evaluated the grouping results using non-parametric test such as Kruskal-Wallis H test, RIV, CV, etc. RESULTS: The 6 DRGs were established as well as criterion of HECP, using age, sex, type of surgery and whether complications/comorbidities occurred as the key variables of classification node of senile cataract cases. CONCLUSION: The grouping of senile cataract cases based on E-CHAID algorithm is reasonable. And the criterion of HECP based on DRG can provide a feasible way of management in the fair use and supervision of medical insurance fund.

  5. Clinical analysis of surgical treatment in patients with senile cataract and hematologic disease

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    Wan-Hui Wang

    2013-11-01

    Full Text Available AIM: To evaluate the clinical efficacy of cataract extraction and intraocular lens implantation in patients with senile cataract and hematologic disease. METHODS: Forty patients(58 eyeswith senile cataract and hematologic disease underwent cataract extraction and intraocular lens implantation. Preoperative assessment included blood coagulation testing, leukocyte classification, and bone marrow examination. Appropriate preoperative treatments were administered to patients with senile cataract and thrombocytopenia, leukopenia, anemia, and/or pancytopenia(identified through blood testing. Thirty patients with senile cataract and normal routine bloodwork findings, with ages similar to those of patients in the study group, were randomly recruited as a control group. Postoperative corrected visual acuity and intraoperative and postoperative complications were recorded. The causes of hematologic disease in patients in the study group were recorded. Blood clotting data were compared between groups using t-tests. RESULTS: Plasma prothrombin time and activated partial thromboplastin time did not differ significantly between the study and control groups(P=0.379 and P=0.945, respectively. Surgery improved corrected visual acuity in all patients(>0.4 in 56 〖96.55%〗 eyes. No postoperative infection, bleeding or fever occurred. The etiology of hematological disease was unknown in some patients; most patients had diabetes mellitus, hypertension, cirrhosis, and/or kidney disease. CONCLUSION: With adequate perioperative treatment, patients with senile cataract and hematological disease can safely undergo cataract operation and intraocular lens implantation, with good outcomes.

  6. Senile anorexia in acute-ward and rehabilitations settings.

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    Donini, L M; Savina, C; Piredda, M; Cucinotta, D; Fiorito, A; Inelmen, E M; Sergi, G; Domiguez, L J; Barbagallo, M; Cannella, C

    2008-10-01

    The most common pathological change in eating behaviour among older persons is anorexia, which accounts for a large percent of undernutrition in older adults. The main research aims are to determine, in a sample of acute and rehabilitation elderly subjects, the prevalence of anorexia of aging and the causes most impacting on senile anorexia. four different Units cooperated to this research study. Patients were recruited from geriatric acute and rehabilitation wards in Italy. Each Research Unit, for the estimation of the prevalence of anorexia in elderly subjects evaluated all the patients aged over 65 recruited from April 2006 to June 2007. Nutritional status, depression, social, functional and cognitive status, quality of life, health status, chewing, swallowing, sensorial functions were evaluated in anorexic patients and in a sample of "normal eating" elderly subjects. 96 anorexic subjects were selected in acute and rehabilitation wards (66 women; 81.5 +/- 7 years; 30 men: 81.8 +/- 8 years. The prevalence of anorexia in the sample was 33.3% in women and 26.7% in men. Anorexic subjects were older and more frequently needed help for shopping and cooking. A higher (although not statistically significant) level of comorbidity was present in anorexic subjects. These subjects reported constipation and epigastrium pain more frequently. Nutritional status parameters (MNA, anthropometry, blood parameters) were significantly worst in anorexic subjects whereas CRP was higher. Chewing and swallowing efficiencies were significantly impaired and eating patterns were different for anorexic subjects with a significant reduction of protein rich foods. consequences of anorexia can be extremely serious and deeply affect both patient's mobility, mortality and quality of life. Therefore, it is of utmost importance to perform a special evaluation of the nutritional risk, to constantly evaluate the nutritional status and feeding intake of older patients, to identify and treat the

  7. Alzheimer's 100th anniversary of death and his contribution to a better understanding of Senile dementia

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    Eliasz Engelhardt

    2015-02-01

    Full Text Available Initially the trajectory of the historical forerunners and conceptions of senile dementia are briefly presented, being highlighted the name of Alois Alzheimer who provided clinical and neuropathological indicators to differentiate a group of patients with Senile dementia. Alzheimer's examination of Auguste D’s case, studied by him with Bielschowsky’s silver impregnation technique, permitted to identify a pathological marker, the intraneuronal neurofibrillary tangles, characterizing a new disease later named after him by Kraepelin – Alzheimer’s disease. Over the time this disorder became one of the most important degenerative dementing disease, reaching nowadays a status that may be considered as epidemic.

  8. Evaluation of the Costs of Caring for the Senile Demented Elderly: A Pilot Study.

    Science.gov (United States)

    Hu, Teh-wei; And Others

    1986-01-01

    Evaluated economic costs for nursing home patients and elderly living in their own homes. Using time records compiled by nurses or family members, the costs incurred annually in caring for a senile demented elderly person at home were estimated to average $11,735, and in a nursing home, $22,458. (Author/BL)

  9. Topical Human Epidermal Growth Factor in the Treatment of Senile Purpura and the Prevention of Dermatoporosis.

    Science.gov (United States)

    McKnight, Braden; Seidel, Rachel; Moy, Ron

    2015-10-01

    Senile purpura presents itself as a largely unexplored challenge as it has been long thought of as a benign condition without long-term health sequelae. It is becoming increasingly accepted that skin aging not only results in cosmetic disturbances, but as a functional ones. With modern increases in lifespan, skin atrophy associated with solar damage is presenting as a clinically significant inability to mechanically protect patients. This chronic cutaneous insufficiency/fragility syndrome was recently termed dermatoporosis and senile purpura appears to be a visible marker of early stage dysfunction. To examine the effects of topically human epidermal growth factor on the clinical presence of senile purpura and its effect on skin thickness as measured via cutaneous ultrasound. Six subjects applied human epidermal growth factor morning and night for six weeks. Clinical outcomes were evaluated by comparing initial clinical photos to 6-week photos and performing a blinded investigator's global assessment (IGA). Skin thickness was evaluated via cutaneous ultrasound measurement. Ultrasound measurements indicated a mean skin thickening of 195.2 ± 35.7 um (SEM) over 6 weeks. The average number of purpuric lesions decreased from 15 ± 4.6 (SEM) to 2.3 ± 0.7 (SEM) over that same period. Senile purpura presents itself as a cosmetic disturbance posing significant psychological distress and serves as a marker of the severity of skin thinning. In this study, we demonstrate that topical h-EGF diminishes the appearance of senile purpura by thickening skin and may help prevent the development of late stage dermatoporosis.

  10. Effects of Simulated Heat Waves on Cardiovascular Functions in Senile Mice

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    Xiakun Zhang

    2014-08-01

    Full Text Available The mechanism of the effects of simulated heat waves on cardiovascular disease in senile mice was investigated. Heat waves were simulated in a TEM1880 meteorological environment simulation chamber, according to a heat wave that occurred in July 2001 in Nanjing, China. Eighteen senile mice were divided into control, heat wave, and heat wave BH4 groups, respectively. Mice in the heat wave and heat wave BH4 groups were exposed to simulated heat waves in the simulation chamber. The levels of ET-1, NO, HSP60, SOD, TNF, sICAM-1, and HIF-1α in each group of mice were measured after heat wave simulation. Results show that heat waves decreased SOD activity in the myocardial tissue of senile mice, increased NO, HSP60, TNF, sICAM-1, and HIF-1α levels, and slightly decreased ET-1 levels, BH4 can relieve the effects of heat waves on various biological indicators. After a comprehensive analysis of the experiments above, we draw the followings conclusions regarding the influence of heat waves on senile mice: excess HSP60 activated immune cells, and induced endothelial cells and macrophages to secrete large amounts of ICAM-1, TNF-α, and other inflammatory cytokines, it also activated the inflammation response in the body and damaged the coronary endothelial cell structure, which increased the permeability of blood vessel intima and decreased SOD activity in cardiac tissues. The oxidation of lipoproteins in the blood increased, and large amounts of cholesterol were generated. Cholesterol penetrated the intima and deposited on the blood vessel wall, forming atherosclerosis and leading to the occurrence of cardiovascular disease in senile mice. These results maybe are useful for studying the effects of heat waves on elderly humans, which we discussed in the discussion chapter.

  11. Clinical study of a retinoic acid-loaded microneedle patch for seborrheic keratosis or senile lentigo.

    Science.gov (United States)

    Hirobe, Sachiko; Otsuka, Risa; Iioka, Hiroshi; Quan, Ying-Shu; Kamiyama, Fumio; Asada, Hideo; Okada, Naoki; Nakagawa, Shinsaku

    2017-01-01

    Pigmented lesions such as of seborrheic keratosis and senile lentigo, which are commonly seen on skin of people>50years of age, are considered unattractive and disfiguring because of their negative psychological impact. Drug therapy using all-trans retinoic acid (ATRA) is an attractive option for self-treatment at home. We have developed an ATRA-loaded microneedle patch (ATRA-MN) and confirmed the pharmacological effects of ATRA-MN application in mice. Here, we describe a clinical study to evaluate the safety and efficacy of ATRA-MN in subjects with seborrheic keratosis or senile lentigo. ATRA-MN was applied to the lesion site of each subject for 6h once per week for 4weeks. The skin irritation reaction was scored to assess adverse reactions and blood tests were performed to evaluate the presence of systemic adverse reactions. To assess the treatment effect using ATRA-MN, the desquamation and whitening ability of the investigational skin was observed. Desquamation of the stratum corneum was observed following four ATRA-MN applications at 1-week intervals, but ATRA-MN applications did not induce severe local or systemic adverse effects. These results showed that ATRA-MN treatment is promising as a safe and effective therapy for seborrheic keratosis and senile lentigo. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. The activity of superoxide dismutase in the aqueous humour of the patients with senile cataract

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    Đokić Olivera

    2016-01-01

    Full Text Available Cataract is a dysfunction of the lens of the eye caused by clouding. By far the most common type of cataract is the senile cataract. The immediate cause of the occurrence of cataract is unknown, but oxidative stress is considered important in its etiopathogenesis. The aim: to examine the intensity of oxidative stress, depending on the type and maturity of senile cataract, through the activity of the superoxide dismutase enzyme (SOD in the aqueous humor of the patients diagnosed with senile cataract. The average activity of the superoxide dismutase enzyme in the aqueous humor of the patients with early nuclear cataract was 41.16 U/mL, which is a significantly higher value (p<0.01 when compared with that of the patients with other types of early cataract, as well as with that of the patients with total cataract (33.88 U/mL. With aging the activity of the superoxide dismutase enzyme decreases, hence the average activity of the enzyme was significantly lower (p<0.05 in the group of patients over 75 years of age (36.28 U/mL vs. 28.91 U/mL.

  13. [Aspects of senile dementia in ancient Rome: literary fiction and factual reality].

    Science.gov (United States)

    Moog, Ferdinand Peter; Schäfer, Daniel

    2007-01-01

    Old people and their pecularities have been the object of writers since the beginning of Western literature. The aim of this study is to verify the social and juridical significance of senile dementia in ancient Rome. Among the few relevant sources the 10th satire of Juvenal attracts attention. It describes a demented patient who revises his succession in favour of a lady with bad reputation. Logically, we wonder whether such dispositions were possible and after all legally binding. Or did Juvenal exaggerate? A look at the Roman legislation shows: Since the Twelve Tablet Law there were instruments to control or to help demented people. This meant care in the sense of the today's curatorship or guardianship. These measures were supposed to prevent extravagancy or doing business and legal acts like marriages or last wills in the state of diminished responsibility. Nevertheless, it must be assumed that there was a considerable discrepancy between juridical theory and daily practice, because the position of the "pater familias" was virtually untouchable, the individual freedom of the full citizen was firmly underlined and the Roman civil law allowed only little executive interferences. Juvenal's bizarre example should not only be taken as good literary fiction. It might reflect the sad, but nevertheless probable reality of the people directly concerned. Apart from that it has to be said that senile dementia played only a minor role in Roman legislation. Mainly because there were considerably less very old people--and in particular people with senile dementia--than today.

  14. A study of 99mTc-HM-PAO brain SPECT in the senile parkinson's disease

    International Nuclear Information System (INIS)

    Chen Wenxin; Lin Xiangtong; Song Wenzhong; Liu Yongchang

    1996-01-01

    Thirty-three cases of senile Parkinson's disease (PD) imaged by 99m Tc-HM-PAO brain SPECT were reported. 66.7% of the patients had cortical hypoperfusion and 18.2% showed asymmetrical hypoperfusion in the basal ganglia. Such a finding was not related with the Hoehn-Yahr stage and the laterality of motor symptoms. If complicated with dementia, the SPECT brain imaging showed similar pattern in Alzheimer's disease with diffuse hypoperfusion in cortical area reflecting widespread pathological changes in tremor paralysis

  15. [Estimation of nutrition of elderly and senile patients with surgical diseases at home].

    Science.gov (United States)

    Malikov, D I

    2005-01-01

    Analysis of estimation of nutrition 500 of elderly and senile patients with surgical disease at home. The diets of patients are characterised by foods rich of animal protein and carbohydrate. But a dificienny of meat, fish, dairy products frent, berries is marhed. The diets thas dificiency in rations of patients are characterized by irrational set basic food products, cannot provide daily needs for nutrients: animal protein, vitamins C, A, vitamins B group, beta-carotene and mineral element--Ca, Mg, P, Zn, Se. Entering of nutrional substance, such as vitamins, and mineral elements with a food is reduced in dietary restrictions, deficiency means, residence in country-side.

  16. Management of Senile Ptosis with Levator Muscle Resection Using the Putterman Clamp

    Science.gov (United States)

    2016-01-01

    Summary: Putterman clamp, a muscle clamp, is commonly used in conjunctival müllerectomies. We report 3 cases of senile ptosis repaired with levator muscle resection using the Putterman clamp. The redundant levator aponeurosis was removed with electrocautery after clamping with the Putterman clamp. The levator muscle was refixed to the tarsus with three 4-0 Vicryl stitches after adjusting the height of the eyelid fissure. No intraoperative difficulties were encountered. Ecchymosis and edema were limited in the immediate postoperative period. No complications were noted during the follow-up. The benefits of using the Putterman clamp in levator muscle resection are illustrated in these cases. PMID:27482474

  17. [A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment].

    Science.gov (United States)

    Li, Hao; Yao, Ming-Jiang; Zhao, Wen-Ming; Guan, Jie; Cai, Lin-Lin; Cui, Ling

    2008-01-01

    To observe the effect and explore the mechanism of Huannao Yicong capsule in treating senile patients with mild cognitive impairment (MCI). The investigational drugs were packed by blind method. A randomized, double-blind and controlled trial was conducted on ninety senile patients with MCI. Other forty-five senile healthy persons were recruited to the healthy control group. The ninety senile patients were randomly divided into the Huannao Yicong capsule-treated group (45 patients administered with three Huannao Yicong capsules and two aniracetam capsule analogues) and aniracetam-treated group (45 patients treated with two aniracetam capsules and three Huannao Yicong capsule analogues). Patients in the two groups were treated three times daily for 16 weeks. Memory, traditional Chinese medicine syndrome, cerebral blood flow, free radicals and inflammatory mediators, such as superoxide dismutase (SOD), malondialdehyde (MDA), acetylcholinesterase (AchE), interleukin-1alpha (IL-1alpha) and interleukin-6 (IL-6) were determined before and after the treatment. Blood lipids, including triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), apolipoprotein A-1 (ApoA-1) and apolipoprotein B-100 (ApoB-100), were detected before and after the treatment. The safety indexes, such as routine tests of blood and urine, hepatic and renal function tests and electrocardiogram (ECG) were taken before and after the treatment. Index score of clinical memory scale in senile healthy people was significantly higher than that in MCI patients before treatment (Paniracetam-treated group (Paniracetam. Furthermore, Huannao Yicong capsule could significantly improve the blood lipid, such as the level of TG, LDL-C, HDL-C, ApoA-1 and ApoB-100 (Paniracetam (Paniracetam capsule in treating senile mild cognitive impairment.

  18. Quantitative measurement of bone mineral contents in patients with senile osteoporosis and chronic renal failure

    International Nuclear Information System (INIS)

    Fukuda, Teruo

    1985-01-01

    Computed tomography using X-ray (XCT) and single photon emission computed tomography (SPECT) using sup(99m)Tc-MDP of the skull were performed in patients with ''senile osteoporosis'' and with chronic renal failure, in order to quantitatively determine bone mineral contents. XCT: In females with postmenopausal osteoporosis (6th decade), the EMI number of frontal bone was significantly low compared with that of control group, of the same age. The EMI number in ''senile osteoporosis'' correlated with the value of serum 25 (OH) D and 1 α - 25 (OH) 2 D. The EMI number in hemodialyzed patients was significantly low compared with that in the control group. On the other hand, the EMI number in non-hemodialyzed chronic renal failure patients showed no significant difference compared with findings in the control group. The EMI number of the frontal bone in patients with partial parathyroidectomy showed a slight rise compared with findings before surgery. Bone scintigram, Bone scan SPECT: Positive scan was seen in patients with long term hemodialysis and increased values of serum Alk-Pase and PTH were often apparent. Scintigraphic improvement in patients with renal osteodystrophy treated with vitamin D 3 showed a good correlation with improvement in serum Alk-Pase values. On SPECT, frontal bone activity in patients with renal osteodystrophy was significantly high compared with that in the control group. In case of renal osteodystrophy treated with partial parathyroidectomy, the frontal bone activity was markedly decreased compared with findings before surgery. (J.P.N.)

  19. Lib, transcriptionally induced in senile plaque-associated astrocytes, promotes glial migration through extracellular matrix.

    Science.gov (United States)

    Satoh, Kazuki; Hata, Mitsumi; Shimizu, Tomoko; Yokota, Hiroshi; Akatsu, Hiroyasu; Yamamoto, Takayuki; Kosaka, Kenji; Yamada, Tatsuo

    2005-09-23

    In an effort to identify astrocyte-derived molecules that may be intimately associated with progression of Alzheimer's disease (AD), Lib, a type I transmembrane protein belonging to leucine-rich repeat superfamily, has been identified as a distinctly inducible gene, responsive to beta-amyloid as well as pro-inflammatory cytokines in astrocytes. To evaluate the roles of Lib in AD, we investigated Lib expression in AD brain. In non-AD brain, Lib mRNA has been detected in neurons but not in quiescent astrocytes. On the contrary, in AD brain, Lib mRNA is expressed in activated astrocytes associated with senile plaques, but not expressed in neurons around lesions. Lib-expressing glioma cells displayed promotion of migration ability through reconstituted extracellular matrix and recombinant Lib protein bound to constituents of extracellular matrix. These observations suggest that Lib may contribute to regulation of cell-matrix adhesion interactions with respect to astrocyte recruitment around senile plaques in AD brain.

  20. Probability of developing severe sepsis in patients of elderly and senile age with necrotic erysipelas

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    Shapkin Yu.G.

    2015-06-01

    Full Text Available Objective: the probable determination of severe sepsis in patients of elderly and senile age with necrotic erysipelas based on a comprehensive assessment (clinical examination using systems — scales and determination of the level markers of SIRS. Material and methods. The analysis of peculiarities of necrotic erysipelas clinical course in 59 patients. The first group consisted of 17 patients with severe sepsis, the second — 18 patients with sepsis without multiple organ failure, in the comparison group —22 patients with local infection. We determined albumin, urea, creatinine, pro-calcitonin of plasma. The scale SAPS III was used to quantify SIRS, scale SOFA —to determine the extent of damage to organs and systems. Results. The most sensitive marker of developing sepsis in patients with necrotic erysipelas was procalcitonin. The second important indicator of SIRS severity in patients with necrotic erysipelas was the blood albumin. Scale SAPS III also allows to select a group of patients with high risk of developing severe sepsis. Use of the SOFA to predict the scale has been found out to be less important. Conclusion. A comprehensive assessment of the severity of the condition by scale SAPS III in combination with determining the levels of procalcitonin and plasma albumin is advisable to apply for prediction the probability of developing severe sepsis in patients of elderly and senile age with necrotic erysipelas. For the last indicator it is important to assess of absolute values and the decrease of its concentration.

  1. Spots before the eyes: A prevalence and clinicoradiological study of senile scleral plaques

    International Nuclear Information System (INIS)

    Moseley, I.

    2000-01-01

    AIMS: To investigate the prevalence and clinical associations of senile scleral plaques. METHODS: Unselected, consecutive computed tomographic (CT) images of elderly people were reviewed for the presence of calcification indicating senile scleral plaques. RESULTS: No definite calcification was seen in 100 men or 100 women aged 60-69 years; equivocal changes were seen in one woman. There were three definite examples and one equivocal case of calcification in 100 women and four definite cases in 100 men aged 70-79 years. However, in a group of 71 men and women patients aged 80 years or more, 16 definite cases were seen, indicating a prevalence of 22%. CONCLUSIONS: Apart from advanced age, and a mild association with the extent of calcification of the carotid siphon, no clinical or radiological features were identified which consistently characterized a total of 28 patients with this form of ocular calcification; an association with cataract probably reflected simply the recruitment base. Scleral plaques would appear to be a degenerative phenomenon without clinical significance, most likely to be detected in patients presenting with unrelated ophthalmological complaints. Moseley, I. (2000)

  2. Risk Factors for Senile Corneal Arcus in Patients with Acute Myocardial Infarction

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    Mirnaghi Moosavi

    2010-01-01

    Full Text Available Purpose: To investigate the association between senile corneal arcus and atherosclerosis risk factors in patients with recent acute myocardial infarction. Methods: In this cross sectional study, atherosclerosis risk factors including fasting blood sugar, total cholesterol and triglyceride levels were measured in 165 patients with recent (less than three months′ duration acute myocardial infarction. Slitlamp examination was performed to detect corneal arcus. Associations between senile corneal arcus and atherosclerosis risk factors were assessed. Results: Overall, 165 patients including 100 male and 65 female subjects with mean age of 62±10.3 years were evaluated. In 122 patients (74%, variable degrees of corneal arcus were observed. The presence of corneal arcus was significantly associated with age (P = 0.03 and high levels of total cholesterol (over 200 mg/dl, P < 0.01. After adjusting for age, arcus was not associated with sex (P = 0.10, hypertriglyceridemia (P = 0.09, fasting blood sugar (P = 0.06, or systemic hypertension (P = 0.08. Conclusion: Our study revealed that corneal arcus is associated with age and hypercholesterolemia in patients with recent acute myocardial infarction. No association was detected with sex, fasting blood sugar, hypertension, and hypertriglyceridemia.

  3. Bacterial aggregates in the tentacles of the sea anemone Metridium senile

    Science.gov (United States)

    Schuett, Christian; Doepke, Hilke; Grathoff, Annette; Gedde, Michael

    2007-09-01

    This paper provides first information on organ-like bacterial aggregates in the tentacles of the sea anemone Metridium senile. The specimens were collected from waters near Helgoland (German Bight, North Sea) and the Orkney Islands. Tentacles were prepared for morphological inspection by light and scanning electron microscopy as well as for the phylogenetic analysis of endocytic bacteria. Bacterial aggregates are located in caverns of the tentacles’ epidermis. The aggregates are enwrapped in thin envelopes, which contain coccoid and/or rod-shaped tightly packed bacteria of different division states. Most of the bacterial cells are connected by fine filamentous structures. The phylogenetic determination is based on the sequence data of the 16S rDNA derived from tentacle material. Sequence analysis revealed three different subgroups of intratentacular proteobacteria. The dominant band, detected in all of the samples tested, showed a close relationship (98%) to a gram-negative Endozoicimonas elysicola. Two bands, only detected in tentacles of M. senile from Helgoland were assigned to Pseudomonas saccherophilia (99%), a knallgas bacterium, and to Ralstonia pickettii (100%). The bacteria represent a specific bacterial community. Their DGGE profiles do not correspond to the profiles of the planktonic bacteria generated from seawater close to the habitats of the anemones. The allocation of DNA sequences to the different morphotypes, their isolation, culturing and the elucidation of the physiological functions of intratentacular bacteria are in progress.

  4. Effects of TimeSlips on Cornell Scale for Depression in Dementia scores of senile dementia patients

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    Hui-Ying Chen

    2016-03-01

    Conclusion: TimeSlips is beneficial to relieve depressive symptoms and ameliorate the emotions of mild or moderate senile dementia patients, thus improving their life quality and reducing the burden of their caregivers. A large-scale experimental research on TimeSlips with rigorous design is proposed for further studies.

  5. Senile retinoschisis versus retinal detachment, the additional value of peripheral retinal OCT scans (SL SCAN-1, Topcon)

    NARCIS (Netherlands)

    Stehouwer, Marilette; Tan, Stevie H.; van Leeuwen, Ton G.; Verbraak, Frank D.

    2014-01-01

    A peripheral senile retinoschisis is sometimes difficult to distinguish from a retinal detachment by biomicroscopy alone. This study evaluated spectral domain OCT (SD-OCT) scans of the far peripheral retina to improve the differentiation between these diseases. Patients were included in whom the

  6. Features of Pathology of the Digestive System in Elderly and Senile Patients and Efficacy of Their Treatment

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    K.O. Voronin

    2013-09-01

    Full Text Available The author presented in the article the results of own study of elderly and senile patients with chronic abdominal ischemia, against which biliary dysfunction and functional constipation had been developed. In the treatment of such patients it is appropriate to include trimebutine and tivortin aspartate, which contribute to positive clinical dynamics.

  7. [Completion technology of pelvic surgery accompanying with cystectomy in elderly and senile patients].

    Science.gov (United States)

    Krest'ianinov, S S; Kostiuk, I P; Shestaev, A Iu; Shostka, K G; Vasil'ev, L A; Kheĭfets, V Kh; Pavlenko, A N; Kagan, O F

    2014-01-01

    Results of treatment of 204 elderly and senile patients who underwent cystprostatectomy or anterior pelvic exenteration are analyzed. A comparative analysis of two groups of patients whose operation ended with the traditional drainage through the anterior abdominal wall (n = 100), and bilateral perineal drainage (n = 104) is presented. Bilateral perineal drainage after operations on the pelvic organs, accompanied by cystectomy and extended lymphadenectomy in conjunction with the restoration of the peritoneum lateral pelvic walls, improves postoperative recovery of intestinal peristalsis, promotes an earlier reduction in the intensity of pain and morbidity in the early postoperative period. Perineal installation of drains is a simple in design and safe procedure. We recommend bilateral perineal drainage after operations on the pelvic organs, accompanied by cystectomy and extended lymphadenectomy.

  8. Senile dementia of the Alzheimer type treated with aniracetam: a new nootropic agent.

    Science.gov (United States)

    Sourander, L B; Portin, R; Mölsä, P; Lahdes, A; Rinne, U K

    1987-01-01

    Forty-four patients with senile dementia of the Alzheimer type were randomly allocated into double-blind treatment with either aniracetam (RO 13-5057) 1 g or placebo daily for 3 months. Neurological examinations were made before and after treatment and psychometric tests were performed before and after 1 month's and after 3 month's treatment. Treatment was interrupted due to occurrence of confusion in four cases in the aniracetam group and in one case in the placebo group. During treatment, an improvement was seen in several cognitive tests, especially those associated with memory, but this improvement occurred in the placebo as well as in the aniracetam-treated group. In clinical evaluation no difference was seen in efficacy between the two treatment groups.

  9. [Contingent negative variation and regional cerebral blood flow in senile dementia and cerebral aging].

    Science.gov (United States)

    Uytdenhoef, P; Depauw, Y; Van Wettere, J P; Godaux, E; Bernier, J; Jacquy, J

    1988-12-01

    Relationships between contingent negative variation (CNV) amplitude, regional cerebral blood flow (CBF), mini mental status examination score (MMSE) and reaction time (RT) have been studied in young subjects, non-demented old subjects and patients with primary degenerative senile dementia. Significant correlations have been found between CNV amplitude and global CBF, MMSE score and reaction time. Factorial analysis has shown 3 factors weighted respectively by MMSE and CNV, antero-posterior ratio fort left hemispheric CBF and age, and antero-posterior ratio for right hemispheric CBF and reaction time. Discriminant analysis has shown 2 discriminant functions differentiating young from old subjects with 90% accuracy and demented from non-demented patients with 75% accuracy.

  10. Tentacle cnidae of the sea anemone Metridium senile (Linnaeus, 1761 (Cnidaria: Anthozoa

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    Carina Östman

    2010-08-01

    Full Text Available Tentacle cnidae of Metridium senile (Linnaeus, 1761 were examined by light microscopy. In addition to spirocysts, feeding-tentacles had 3 nematocyst categories grouped into medium and small size-classes, including 5 types. Spirocysts dominated, especially distally, followed by medium b-mastigophores. The density of cnidae decreased towards the tentacle base. Early cnidoblasts were numerous on the tentacle tip. Late cnidoblasts appeared in a moderate number on the mid-tentacle. Catch-tentacles, found in two Metridium specimens, had a maturity gradient of isorhizas and gland cells along their length. Their tip had two distinct types of mature isorhizas in great numbers and large gland cells, but lacked spirocysts. Mature isorhizas and gland cells decreased in number towards the tentacle base. On the mid-tentacle differentiating ages of isorhizas were numerous. Ordinary feeding-tentacle cnidae, abundant at the tentacle base, decreased in number distally along the tentacle.

  11. Senile retinoschisis versus retinal detachment, the additional value of peripheral retinal OCT scans (SL SCAN-1, Topcon).

    Science.gov (United States)

    Stehouwer, Marilette; Tan, Stevie H; van Leeuwen, Ton G; Verbraak, Frank D

    2014-05-01

    A peripheral senile retinoschisis is sometimes difficult to distinguish from a retinal detachment by biomicroscopy alone. This study evaluated spectral domain OCT (SD-OCT) scans of the far peripheral retina to improve the differentiation between these diseases. Patients were included in whom the distinction between retinal detachment and senile retinoschisis was not clear based on biomicroscopy alone, or who had a presumed clinical diagnosis of senile retinoschisis. OCT scans were made with the SLSCAN-1, through a hand-held lens and a 3-mirror contact lens, while the area of interest was simultaneously observed with the slit lamp. The SLSCAN-1 is a SD-OCT integrated into a slit lamp, superluminescent diode light source with a central wavelength of 830 nm, bandwidth 30 nm, scan resolution 8-9 μm in tissue, scan depth 2 mm, scan speed 5000 A-scans per second. In the 11 patients with an uncertain diagnosis, OCT scans showed a senile retinoschisis in four and a retinal detachment in seven patients. Fifteen of the 18 patients with a presumed diagnosis of retinoschisis showed a retinoschisis on OCT. In five of them, the OCT scans revealed a schisis detachment. Interestingly, three of the 18 patients had a retinal detachment. Senile retinoschisis may mimic a peripheral retinal detachment and vice versa. Differentiation is important with respect to therapeutic decisions. OCT scans of the far peripheral retina, which can be made with the SLSCAN-1 through a 3-mirror contact lens, can contribute significantly to this differentiation. The obtained scans of the far peripheral retina clearly visualize the anatomic differences between both diseases. © 2013 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

  12. The venous manifestations of pulse wave encephalopathy: windkessel dysfunction in normal aging and senile dementia

    Energy Technology Data Exchange (ETDEWEB)

    Bateman, Grant A. [Locked Bag 1, Newcastle Region Mail Center, Department of Medical Imaging, John Hunter Hospital, Newcastle (Australia); Levi, Christopher R.; Wang, Yang; Lovett, Elizabeth C. [Hunter Medical Research Institute, Clinical Neurosciences Program, Newcastle (Australia); Schofield, Peter [James Fletcher Hospital, Neuropsychiatry Unit, Newcastle (Australia)

    2008-06-15

    Cerebral arterial, venous and cerebrospinal fluid (CSF) pulsations are closely coupled and this produces pulsation dampening or the windkessel effect. Normal pressure hydrocephalus is a manifestation of the breakdown of this windkessel effect with altered CSF and venous pulsations being noted. The aim of this study was to show that dysfunction of the windkessel mechanism is also a component of normal aging and senile dementia. The study group comprised 24 patients classified as either early senile dementia of Alzheimer's type (SDAT) or vascular dementia (VaD). The patients with dementia were compared with 12 age-matched non-cognitively impaired subjects, and 12 normal young individuals were compared with the normal aging group. MRI flow quantification was used to measure the nonpulsatile and pulsatile components of blood flow as well as the pulsation at the tentorial incisura. With normal aging blood flow decreased but arterial pulsations increased in volume by 49% (P = 0.003). The CSF vented via the tentorial incisura does not change significantly with age and therefore increased venous pulsation is necessary. In patients with VaD the arterial pulse volume was higher by 24% and the straight sinus pulsation was higher by 57% than in normal aging subjects (P = 0.05 and P = 0.03, respectively). In patients with SDAT the total venous pulsation volumes were similar to those in normal aging subjects but there was less basal sinus pulsation. Normal aging, SDAT and VaD are associated with alterations in venous pulsation due to a breakdown of the windkessel effect. (orig.)

  13. Buckberg's blood cardioplegia for protection of adult and senile myocardium in a rat in vitro model of acute myocardial infarction.

    Science.gov (United States)

    Boening, Andreas; Assling-Simon, Lena; Heep, Martina; Boengler, Kerstin; Niemann, Bernd; Grieshaber, Philippe

    2018-04-01

    In patients undergoing surgical myocardial revascularization for acute myocardial infarction, excellent myocardial protection can be achieved by blood cardioplegia. We investigated the influence of age on cardiac function, metabolism, and infarct size using Buckberg's blood cardioplegia (BCP). The hearts of male Wistar rats ("adult", age 3 months, n = 8; "senile", age 24 months, n = 8) were excised and mounted on a blood-perfused isolated heart apparatus. An acute myocardial infarction was induced by coronary artery ligation for 30 min before aortic clamping and infusion of Buckberg's BCP. Throughout the experiment, functional parameters were recorded: coronary blood flow (normalized by heart weight), left ventricular peak developed pressure (LVpdP), and positive and negative derived left ventricular pressure over time (dLVPdt max and dLVPdt min ). Oxygen consumption (MVO 2 ) and lactate production of the hearts were calculated. The infarct size after 90 min of reperfusion (in % of the area at risk) was measured with triphenyl tetrazolium chloride staining of the myocardium. The baseline coronary flow normalized by heart weight was significantly lower in the senile hearts (1.6 ± 0.4 ml/(min ∗ g)) compared with the adult hearts (2.0 ± 0.3 ml/(min ∗ g); p = 0.04). After 90 min of aortic clamping, hemodynamic function of senile hearts recovered better than that of adult hearts: LVpdP (adult 57% of baseline [BL]; senile 88% BL; p = 0.044) and dLVPdt max (adult 74% BL, senile 102% BL; p = 0.12). In contrast, myocardial infarct size was similar between the adult (26%) and senile (21%; p = 0.45) hearts, and coronary flow recovered to a similar extent (55% BL and 58% BL, respectively). During reperfusion, MVO 2 (80% BL and 81% BL) and lactate production (1.2 and 1.3 μmol/min) were similar in the two groups. After acute myocardial infarction in a rat model, hearts recovered function after reperfusion with

  14. Effect Of GAMMA Irradiated Thyme As Natural Antioxidant On Hypercholesterolemia Senile Rats

    International Nuclear Information System (INIS)

    El-Shahat, A.N.; Hamza, R.G.

    2011-01-01

    Hypercholesterolemia, high cholesterol diet and oxidative stress increase serum total cholesterol and LDL-cholesterol levels resulting in increased risk for development of atherosclerosis. Thyme (as antioxidant) has been commonly used in foods mainly for the flavour and preservation and also as herbal medicinal products. Antioxidants play an important role in inhibiting and scavenging free radicals, thus, providing protection to humans against infectious and degenerative diseases. This study was carried out to determine the effect of using thyme as supplement on serum levels of lipids, glucose and lipid peroxidation in hypercholesterolemia senile rats. GC-MS analysis of essential oil showed that the number of identified compounds was 12, especially thymol and carvacrol (natural antioxidants). Senile male rats were fed on hypercholesterolemia diet (HCD) containing cholesterol (1% w/w) and sodium cholate (0.2% w/w). Twenty eight male rats were equally and randomly categorized into four groups. Rats of group (1) fed on balanced commercial diet, group (2) fed on high cholesterol diet for 8 weeks, groups (3) and (4) fed on high cholesterol diet supplemented with either raw or irradiated thyme (1% w/w) for 8 weeks. The results obtained revealed that rats fed on high cholesterol diet significantly showed increase in serum total lipids, TG, TC, LDL-C, VLDL-C as well as ratio risk, associated with remarkable decrease in HDL-C. A significant increase was observed in the level of lipid peroxidation (TBARS) associated with significant decrease in hepatic antioxidant enzymes (glutathion reductase; GSH and catalase; CAT) and total antioxidant capacity. Also, high cholesterol diet induced significant elevation in the level of glucose and liver enzymes (AST, ALT, ALP). The results obtained revealed that feeding rats on HCD containing either raw or irradiated thyme (1% w/w) induced significant improvement in the mentioned parameters. Also, the thyme suppressed lipid peroxidation

  15. Alendronat tedavisinin senil osteoporozlu hastalarda idrar kalsiyum/kreatinin oranı üzerine etkisinin değerlendirilmesi

    OpenAIRE

    Yörükoğlu, Elçin; Okuyan, Betül; Sancar, Mesut; İzzettin, Fikret Vehbi

    2011-01-01

    Objective: In this study, it is aimed to assess the effects of alendronate treatment on urinary calcium/creatinine ratio in female patients newly diagnosed as senile osteoporosis and prescribed alendronate treatment.Method: According to this aim, urinary calcium/creatinine ratio were measured at baseline and after 3 months alendronate therapy and also the levels of serum calcium , phosphorus, alkaline phosphatase (ALP), parathyroid hormone (PTH) were evaluated.Results: Statistically significa...

  16. ALGORITHM OF DIAGNOSTICS AND TREATMENT OF ELDERLY AND SENILE PATIENTS WITH ACUTE CHOLECYSTITIS, CHOLEDOCHOLITHIASIS AND OBSTRUCTIVE JAUNDICE

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    M. D. Dibirov

    2017-01-01

    Full Text Available We performed a retrospective analysis of treatment in 4,197 patients with acute cholecystitis. Destructive complicated cholecystitis was diagnosed in 658 (25.3% patients . There were 431 (65.5% patients of elderly and senile age. All patients had comorbidities. Cardiovascular insufficiency — 73.9%, respiratory diseases — 29.2%, diabetes — 26%. For urgent indications, 12 (2.8% patients were operated, 2 (16.6% of them died. In 419 (97.2% patients, mini-invasive treatment was performed. Endoscopically, jaundice wasn’t managed in 86 (20.5% cases. In 62 (14.8% cases, percutaneous transhepatic microcholangiography was performed under ultrasound guidance. Laparoscopic cholecystectomy was performed in 183 (43.6 % cases, traditional cholecystectomy was performed in 149 (35.6% cases, and in 38 of them (23.9% it was combined with Kerr’s drainage of choledoch. Mini-invasive cholecystectomy was performed in 87 (20.7% cases. Postoperative complications were revealed in 21 (5.0% patients, in 7 (2.9% of elderly age and 14 (7.9% of senile age. Postoperative mortality rate was 2.0%. The use of minimally invasive interventions in the complex treatment of this group of patients was the main goal and it was reasoned by the severity of the initial condition of elderly and senile patients.

  17. Aniracetam. An overview of its pharmacodynamic and pharmacokinetic properties, and a review of its therapeutic potential in senile cognitive disorders.

    Science.gov (United States)

    Lee, C R; Benfield, P

    1994-03-01

    Aniracetam is a member of the nootropic class of drugs, which have possible cognition enhancing effects. It appears to positively modulate metabotropic glutamate receptors and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-sensitive glutamate receptors, and may facilitate cholinergic transmission, effects which are possibly related to its mechanism of action. Results from trials in elderly patients with mild to moderate cognitive impairment due to senile dementia of the Alzheimer type suggest that aniracetam may be of benefit, with further trials required to confirm its efficacy profile and to define more precisely those patients most likely to respond to treatment. Aniracetam 1500 mg/day was significantly more effective than placebo in all tests at 4 and 6 months, and in a further 6-month trial was more effective than piracetam 2400 mg/day in 8 of 18 tests. Preliminary evidence in the treatment of patients with cognitive impairment of cerebrovascular origin suggests aniracetam may also be of benefit in this condition. Whilst incidence rates of adverse effects are not yet available, data from trials suggest aniracetam is well tolerated. In particular, aniracetam does not appear to cause increases in liver enzyme levels. The evaluation of drugs for patients with senile cognitive disorders is a difficult area and therapeutic options are currently limited. Preliminary evidence of the potential benefits and good tolerability profile of aniracetam support continued evaluation of its use in patients with mild to moderate senile dementia of the Alzheimer type.

  18. The effects of music intervention on the emotion, haemodynamics and endocrine hormone level of senile patients during the perianesthesia period

    Directory of Open Access Journals (Sweden)

    Liang Feng

    2017-01-01

    Full Text Available Purpose: to explore the effects of music intervention on haemodynamics and endocrine hormone level of senile patients. Methods: choosing ASA II-III level and selecting 60 senile patients performed with intraspinal anesthesia; randomly dividing them into the intervention group and control group with 30 cases in each group. Both the two groups of patients completed the SAS before entering the operating room. When the patients of the intervention group entered the operating room, selected music would be played in a continuous loop immediately till the end of the operation while the doctors of the control group just told the patient to relax without music or other special treatment. Recording and comparing the SAS scores, SBP, HR and salivary cortisol concentration of the two groups before and after intervention. Results: the SAS scores, SBP, HR and salivary cortisol concentration of the intervention group were significantly decreased compared with the value before intervention and the differences within and between the groups were significant (P < 0.05. Conclusion: music intervention can effectively reduce the preoperative anxiety, ease intranperative tension and maintain the stability of hemodynamics, so it is beneficial for senile parents to live through the perianesthesia period.

  19. [Behavioral, stress and immunological evaluation methods of music therapy in elderly patients with senile dementia].

    Science.gov (United States)

    Suzuki, Mizue; Kanamori, Masao; Nagasawa, Shingo; Saruhara, Takayuki

    2005-01-01

    The purpose of this study was to clarify the efficacy of behavioral, stress and immunological evaluation methods in music therapy (MT) with elderly patients with senile dementia. The MT group consisted of 8 elderly patients with dementia and the control group included 8 similarly matched patients. A total of 25 sessions of music therapy were conducted for one hour, twice each week for three months. The Mini-Mental State Exam (MMSE), Gottfries-Brane-Steen Scale (GBS), and Behavioral Pathology in Alzheimer's Disease Rating Scale (Behave-AD) were used to evaluate behavioral changes. Saliva Chromogranin A (Cg A) and Immunoglobulin A (Ig A) were used to assess changes in stress and immunological status, respectively. The results of the study were as follows: 1. In GBS, the mean score of "different symptoms common in dementia" improved significantly after MT. 2. The mean Behave-AD score of "paranoid and delusional ideation" was also significantly improved (p<0.05) after the intervention. 3. In the 25th session, mean saliva Cg A was significantly decreased after MT (p<0.05). IgA was slightly increased prior to intervention. Our results suggest that a combination of behavioral, stress and immunological evaluation methods were valuable for assessing changes that occurred during MT for elderly patients with dementia.

  20. Senile dementia of the Binswanger type: a vascular form of dementia in the elderly

    Energy Technology Data Exchange (ETDEWEB)

    Roman, G.C.

    1987-10-02

    Computed tomography and magnetic resonance imaging in the elderly have demonstrated the common occurrence of deep white-matter lesions in the aging brain. These radiologic lesions (leukoaraiosis) may represent an early marker of dementia. At autopsy, an ischemic periventricular leukoencephalopathy (Binswanger's disease) has been found in most cases. The clinical spectrum of Binswanger's disease appears to range from asymptomatic radiologic lesions to dementia with focal deficits, frontal signs, pseudobulbar palsy, gait difficulties, and urinary incontinence. The name senile dementia of the Binswanger type (SDBT) is proposed for this poorly recognized, vascular form of subcortical dementia. The SDBT probably results from cortical disconnections most likely caused by hypoperfusion. In contrast, multi-infarct dementia is correlated with multiple large and small strokes that cause a loss of over 50 to 100 mL of brain volume. The periventricular white matter is a watershed area irrigated by long, penetrating medullary arteries. Risk factors for SDBT are small-artery diseases, such as hypertension and amyloid angiopathy, impaired autoregulation of cerebral blood flow in the elderly, and periventricular hypoperfusion due to cardiac failure, arrhythmias, and hypotension. The SDBT may be a potentially preventable and treatable form of dementia.

  1. Regional cerebral blood flow and brain atrophy in senile dementia of Alzheimer type (SDAT)

    International Nuclear Information System (INIS)

    Okada, Kazunori; Kobayashi, Shoutai; Yamaguchi, Shuhei; Kitani, Mituhiro; Tsunematsu, Tokugoro

    1987-01-01

    To investigate the relationship between the reduction of cerebal blood flow and brain atrophy in SDAT, these were measured in 13 cases of senile dementia of Alzheimer type, and compared to 15 cases of multi-infarct Dementia, 39 cases of lacunar infarction without dementia (non-demented CVD group) and 69 cases of aged normal control. Brain atrophy was evaluated by two-dimensional method on CT film by digitizer and regional cerebral blood flow (rCBF) was measured by 133 Xe inhalation method. The degree of brain atrophy in SDAT was almost similar of that of MID. But it was more severe than that of non-demented group. MID showed the lowest rCBF among these groups. SDAT showed significantly lower rCBF than that of aged control, but rCBF in SDAT was equal to that of lacunar stroke without dementia. Focal reduction of cerebral blood flow in bilateral fronto-parietal and left occipital regions were observed in SDAT. Verbal intelligence score (Hasegawa's score) correlated with rCBF and brain atrophy index in MID, and a tendency of correlation between rCBF and brain atrophy in MID was also observed. However, there was no correlation among those indices in SDAT. These findings suggest that the loss of brain substance dose not correspond to the reduction of rCBF in SDAT and simultaneous measurement of rCBF and brain atrophy was useful to differ SDAT from MID. (author)

  2. Pineal and pituitary-adrenocortical function in physiological aging and in senile dementia.

    Science.gov (United States)

    Ferrari, E; Arcaini, A; Gornati, R; Pelanconi, L; Cravello, L; Fioravanti, M; Solerte, S B; Magri, F

    2000-12-01

    The simultaneous evaluation of the circadian rhythm of plasma melatonin and ACTH and of serum cortisol and DHEAS represents a clinically reliable tool to appreciate the neuroendocrine changes occurring in physiological and pathological brain aging.A selective impairment of the nocturnal melatonin secretion has been observed in elderly subjects, being significantly related either to the age or to the severity of dementia. A significant increase of serum cortisol levels during evening- and night-times was found in elderly subjects, particularly if demented, when compared to young controls. Besides, both the circadian amplitude of cortisol rhythm and the nocturnal cortisol increase were significantly reduced in relation either to age or to cognitive impairment. By comparison to vascular dementia, patients with Alzheimer's disease exhibited the highest cortisol concentrations throughout the 24h. The sensitivity of the hypothalamic-pituitary-adrenal axis to the steroid feedback was significantly impaired in old subjects and particularly in the demented ones. The serum DHEAS levels were significantly lower in elderly subjects and even more in demented patients than in young controls. Consequently, a significant increase of the cortisol/DHEAS molar ratio was evident when going from young controls to healthy elderly subjects and to demented patients. In conclusion, the aging process affects many neuroendocrine functions resulting in subtle but clinically relevant consequences; the occurrence of senile dementia seems to play an additive role.

  3. Senile dementia of the Binswanger type: a vascular form of dementia in the elderly

    International Nuclear Information System (INIS)

    Roman, G.C.

    1987-01-01

    Computed tomography and magnetic resonance imaging in the elderly have demonstrated the common occurrence of deep white-matter lesions in the aging brain. These radiologic lesions (leukoaraiosis) may represent an early marker of dementia. At autopsy, an ischemic periventricular leukoencephalopathy (Binswanger's disease) has been found in most cases. The clinical spectrum of Binswanger's disease appears to range from asymptomatic radiologic lesions to dementia with focal deficits, frontal signs, pseudobulbar palsy, gait difficulties, and urinary incontinence. The name senile dementia of the Binswanger type (SDBT) is proposed for this poorly recognized, vascular form of subcortical dementia. The SDBT probably results from cortical disconnections most likely caused by hypoperfusion. In contrast, multi-infarct dementia is correlated with multiple large and small strokes that cause a loss of over 50 to 100 mL of brain volume. The periventricular white matter is a watershed area irrigated by long, penetrating medullary arteries. Risk factors for SDBT are small-artery diseases, such as hypertension and amyloid angiopathy, impaired autoregulation of cerebral blood flow in the elderly, and periventricular hypoperfusion due to cardiac failure, arrhythmias, and hypotension. The SDBT may be a potentially preventable and treatable form of dementia

  4. Relationships between automated EEG and cranial CT in patients with senile dementia

    International Nuclear Information System (INIS)

    Mori, Katsumi; Miyasaka, Mutue; Nakano, Takashi; Ohtaka, Tadashi

    1988-01-01

    The degree of dementia was examined in relation to findings of automated EEG and cranial CT in 50 demented old patients aged 51 - 86. Slow waves on EEC, and dilated ventricle and atrophied cortex on cranial CT were frequently associated with poor psychological scores. As the degree of dilated ventricle increased, the frequency and amplitude of slow waves increased and the frequency and continuity of α waves decreased. Dilated ventricle was more strongly correlated with abnormal EEG findings than atrophied cortex. This was more marked in cases of severer patients. Abnormal EEC findings associated with poor psychological scores were more frequently observed in the group of patients with vascular dementia (VD, n = 30) than the group of patients with senile dementia of Alzheimer type (SDAT, n = 20). Abnormal EEG findings were correlated with poor scores on Hasegawa test in the VD group and with those on Bender Gestalt test in the SDAT group. The degree of dilated ventricle was more correlated with abnormal EEG findings in the SDAT group than the VD group. (Namekawa, K.)

  5. Progressive senile scoliosis: Seven cases of increasing spinal curves in elderly patients

    Energy Technology Data Exchange (ETDEWEB)

    Gillespy, T. III; Gillespy, T. Jr.; Revak, C.S.

    1985-04-01

    An increasing scoliosis was documented in seven elderly women. The average curve at the most recent examination was 43/sup 0/ (range 26/sup 0/-78/sup 0/). Previous films, from 5 to 26 years before, demonstrated an average increase of 2.3/sup 0//year (range 1/sup 0/-4.8/sup 0//year). There were three lumbar and four thoracolumbar curves. Three curves were to the right and four were to the left. Only one patient had osteoporotic vertebral body crush fractures. The common underlying mechanism in the progression of senile scoliosis appears to be asymmetric loading of the spine which can be caused by a previously established scoliosis, spondylolysis/spondylolisthesis, lumbosacral anomalies, or leg length discrepancy. Subsequently, factors that can cause a curve to increase include degenerative disc disease with lateral disc space narrowing, soft tissue failure, and osteoporosis. Since even minor scoliosis can potentially progress in the older adult, increased monitoring of scoliosis in patients over age 50 years may be warranted.

  6. Progressive senile scoliosis: Seven cases of increasing spinal curves in elderly patients

    International Nuclear Information System (INIS)

    Gillespy, T. III; Revak, C.S.

    1985-01-01

    An increasing scoliosis was documented in seven elderly women. The average curve at the most recent examination was 43 0 (range 26 0 -78 0 ). Previous films, from 5 to 26 years before, demonstrated an average increase of 2.3 0 /year (range 1 0 -4.8 0 /year). There were three lumbar and four thoracolumbar curves. Three curves were to the right and four were to the left. Only one patient had osteoporotic vertebral body crush fractures. The common underlying mechanism in the progression of senile scoliosis appears to be asymmetric loading of the spine which can be caused by a previously established scoliosis, spondylolysis/spondylolisthesis, lumbosacral anomalies, or leg length discrepancy. Subsequently, factors that can cause a curve to increase include degenerative disc disease with lateral disc space narrowing, soft tissue failure, and osteoporosis. Since even minor scoliosis can potentially progress in the older adult, increased monitoring of scoliosis in patients over age 50 years may be warranted. (orig.)

  7. Apendicitis aguda en el paciente senil: Factores asociados a una mayor morbimortalidad post operatoria

    Directory of Open Access Journals (Sweden)

    Víctor Eduardo Chian Chang

    1996-04-01

    Full Text Available Objetivo: Definir los factores asociados a una mayor morbilidad y mortalidad en pacientes seniles con apendicitis aguda. Material y métodos: Se realizó un estudio retrospectivo con 100 pacientes intervenidos en el Hospital Nacional Arzobispo Loayza, durante el período comprendido entre 1984 a 1994. Resultados: Se asociaron a una mayor frecuencia de complicaciones postoperatorias: edad mayor o igual a 70 años, tiempo de enfermedad mayor de 48 horas, presencia de apendicitis perforada con peritonitis localizada o generalizada (p<0.05. Además la presencia de apendicitis perforada se asoció significativamente a la presencia de absceso residual y/o fístula estercorácea (p=0.027 y la presencia de AA gangrenosa o perforada a mayor frecuencia de infección de herida operatoria (p<0.05. El antecedente de patología cardiovascular previa se asoció a mayor frecuencia de complicaciones cardiovasculares (p<0.05. Se asociaron a mayor mortalidad en AA, pacientes con intervención quirúrgica adicional a la apendicetomía (p=0.016 y presencia de AA perforada (p=0.027. Conclusiones: Los estadios avanzados de AA, así como la presencia de problema cardiovascular al momento del diagnóstico se asociaron con una mayor frecuencia de complicaciones post-operatorias. La presencia de peritonitis se asocia con la mortalidad. (Rev Med Hered 1996; 7: 62-67.

  8. Comparison of Apraxia between Patients with Senile Dementia of Alzheimer Type and Normal Aged People

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    Fariba Yadegari

    2007-07-01

    Full Text Available Objective: In addition to memory deficits and aphasia, many patients with Alzheimer’s disease (AD are apraxic which may bring about disturbances in their daily living. The purpose of present study was investigating the presence of any apraxic disorder in patients with senile dementia of Alzheimer type (SDAT and comparison with normal aged people. Materials & Methods: In this case–control and analytical study 14 SDAT patients were compared with 20 normal ageing people that they were matched with patients according to age and education. Patients were selected from Iranian Alzheimer Association clients with psychiatrist diagnostic confirmation and MMSE scores between 15-27 and compared with controls with MMSE scores between 25-30. Apraxia Test was administered on both groups. The Test included 4 subtests: conceptual movements gestured conceptual movements, oral and respiratory movements & pantomime of movements of object manipulations. Data was analyzed by using Kolmogoroff – Smirnoff test, Man – Witney, T-test for independent groups and pearsonian correlation coefficient. Results: Findings showed that apraxia scores were significantly (P<0/001 different between groups so that (SDAT patients were diagnosed as apraxic and controls were not. Besides, comparison of subtests scores of (SDAT patients revealed that conceptual movements scores were significantly (P<0/001 less than the other subtests (more apraxic and oral and respiratory movements scores were significantly (P<0/001 higher than the other subtests (less apraxic. Conclusion: Apraxia could be considered as one of the neuropsychological signs early in the disease development. It can be applied complementarily for differential diagnosis. Also apraxia subgroup scoring could be used for apraxia categorization, understanding observed disorders and determining possible rehabilitation ways.

  9. Morfometria do miocárdio humano em indivíduos senis Morphometry of human myocardium in senile individuals

    Directory of Open Access Journals (Sweden)

    José Antonio Cardoso

    2006-05-01

    Full Text Available OBJETIVO: Realizar uma avaliação quantitativa nas células do miocárdio humano de indivíduos senis, nas regiões ventriculares direita, esquerda e septal. MÉTODOS: Foram utilizados cinco corações de cadáveres de indivíduos sem enfermidades cardíacas, de ambos os sexos, com idade entre 67 e 87 anos. Foram avaliados os seguintes parâmetros: área da secção transversa unitária do miócito (a o mioc; comprimento do perímetro unitário do miócito (l o mioc; volume unitário do miócito (v o mioc; densidade volumétrica dos miócitos (Vv mioc; número de miócitos por unidade de volume (Nmm ^³mio. Na análise estatística utilizou-se o teste "t" de Student. RESULTADOS: A análise das diferenças (pOBJECTIVE: To carry out a quantitative assessment in human myocardium cells of senile individuals, in right, left and septal ventricular regions. METHODS: Five hearts from corpses of individuals without heart diseases, of both sexes, with age between 67 and 87 years old were used. The following parameters were assessed: myocyte unit cross section area (myoc. a o; myocyte unit perimeter length (myoc. l o; myocyte unit volume (myoc. v o; myocyte volumetric density (myoc. Vv; number of myocytes per volume unit (Nmm ^³myoc.. The t-test of Student was used in statistic analysis. RESULTS: The analysis of differences (p < 0.05 among right (RV, left (LV and septal (S ventricular regions of human heart showed that myoc. a o values were lower in RV (1.51 ± 0.10 µm² and in S (1.55 ± 0.07 µm² in relation to LV (1.84 ± 0.24 µm². Values of myoc. l o were also shown lower in S (5.11 ± 0.46 µm comparing to LV (6.2 ± 0.97 µm. Likewise, myoc. v o and myoc. Vv showed lower values in RV (88.75 ± 25.37 µm ³; 0.39 ± 0.03% in relation to LV (122.41 ± 16.31 µm ³; 0.41 ± 0.01%. CONCLUSION: Results obtained show that there may be changes in dimensions of left ventricular wall myocyte cell during senescent stage. However, those differences are

  10. Characterization of Proteins Present in Isolated Senile Plaques from Alzheimer's Diseased Brains by MALDI-TOF MS with MS/MS.

    Science.gov (United States)

    Kelley, Andrea R; Perry, George; Bach, Stephan B H

    2018-04-18

    The increase of insoluble senile plaques in the brain is a primary hallmark of Alzheimer's disease. The usefulness of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) with tandem MS for the characterization of senile plaques from AD brains and the relevance of the components identified to furthering AD research using MS is discussed. Thirty-three components were reproducibly observed within tryptic aliquots of senile plaques from two different AD brains after sample preparation optimization. Additionally, this is one of the first accounts of LIFT being utilized for the direct sequencing of peptides from isolated senile plaques. While many of the species observed coisolated within senile plaques have been linked to AD etiology, if only speculatively, this is the first instance that many of them have been demonstrated to be a part of the plaques themselves. This work is the first step in determining the potential roles that the species may have in the aggregation or proliferation of the plaques.

  11. Dexmedetomidine Acts via the JAK2/STAT3 Pathway to Attenuate Isoflurane-Induced Neurocognitive Deficits in Senile Mice.

    Directory of Open Access Journals (Sweden)

    Yanna Si

    Full Text Available Previous studies showed that isoflurane-induced cognitive deficits could be alleviated by dexmedetomidine in young animal subjects. In the current study, we examine whether dexmedetomidine could also alleviate isoflurane-induced cognitive deficits in senile animals.Senile male C57BL/6 mice (20 months received dexmedetomidine (50 μg/kg, i.p. or vehicle 30 minutes prior to isoflurane exposure (1.3% for 4 h. Cognitive function was assessed 19 days later using a 5-day testing regimen with Morris water maze. Some subjects also received pretreatment with α2 adrenoreceptor antagonist atipamezole (250 μg/kg, i.p., JAK2 inhibitor AG490 (15 mg/kg i.p. or STAT3 inhibitor WP1066 (40 mg/kg i.p. 30 minutes prior to dexmedetomidine.Isoflurane exposure increased and reduced the time spent in the quadrant containing the target platform in training sessions. The number of crossings over the original target quadrant was also decreased. Dexmedotomidine attenuated such effects. Effects of dexmedotomidine were reduced by pretreatment with atipamezole, AG490 and WP1066. Increased phosphorylation of JAK2 and STAT3 in the hippocampus induced by isoflurane was augmented by dexmedetomidine. Effects of dexmedetomidine on JAK2/STAT3 phosphorylation were attenuated by atipamezole, AG490 and WP1066. Isoflurane promoted neuronal apoptosis and increased the expression of cleaved caspase-3 and BAD, and reduced Bcl-2 expression. Attenuation of such effects by dexmedotomidine was partially blocked by atipamezole, AG490 and WP1066.Dexmedetomidine could protect against isoflurane-induced spatial learning and memory impairment in senile mice by stimulating the JAK2/STAT3 signaling pathway. Such findings encourage the use of dexmedetomidine in geriatric patients receiving isoflurane anesthesia.

  12. Morphological and molecular characterization of the senile osteoporosis in senescence-accelerated mouse prone 6 (SAMP6).

    Science.gov (United States)

    Azuma, Kagaku; Zhou, Qian; Kubo, Kin-Ya

    2018-04-04

    Although the understanding of the complex pathogenesis for osteoporosis is appreciable, the underlying mechanism is not yet fully elucidated. There is a great need to further characterize the available animal models in osteoporosis research. The senescence-accelerated mouse prone 6 (SAMP6) mice have been developed as the spontaneous experimental model for senile osteoporosis. Here, we provide a comprehensive overview of current research regarding the bone morphological and molecular alterations and the possible mechanisms involved in these changes. There were significant decrease in trabecular bone mass at the axial and appendicular skeletal sites, with no marked alterations of cortical bone. Decreased bone formation on the endosteal surface and trabecular bone, and increased bone marrow adiposity were observed in SAMP6 mice. The elevated expression level of proliferator activator gamma (PPARγ) in the bone marrow suggest that PPARγ might regulate osteoblastic bone formation negatively in SAMP6 mice. The expression level of secreted frizzled-related protein 4 (Sfrp4) was found to be higher in SAMP6 mice. Sfrp4 is considered to suppress osteoblastic proliferation mediated by inhibition of Wnt signaling pathway. These findings may help us to gain more insight into the potential mechanism of senile osteoporosis.

  13. Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair.

    Science.gov (United States)

    Wood, J M; Decker, H; Hartmann, H; Chavan, B; Rokos, H; Spencer, J D; Hasse, S; Thornton, M J; Shalbaf, M; Paus, R; Schallreuter, K U

    2009-07-01

    Senile graying of human hair has been the subject of intense research since ancient times. Reactive oxygen species have been implicated in hair follicle melanocyte apoptosis and DNA damage. Here we show for the first time by FT-Raman spectroscopy in vivo that human gray/white scalp hair shafts accumulate hydrogen peroxide (H(2)O(2)) in millimolar concentrations. Moreover, we demonstrate almost absent catalase and methionine sulfoxide reductase A and B protein expression via immunofluorescence and Western blot in association with a functional loss of methionine sulfoxide (Met-S=O) repair in the entire gray hair follicle. Accordingly, Met-S=O formation of Met residues, including Met 374 in the active site of tyrosinase, the key enzyme in melanogenesis, limits enzyme functionality, as evidenced by FT-Raman spectroscopy, computer simulation, and enzyme kinetics, which leads to gradual loss of hair color. Notably, under in vitro conditions, Met oxidation can be prevented by L-methionine. In summary, our data feed the long-voiced, but insufficiently proven, concept of H(2)O(2)-induced oxidative damage in the entire human hair follicle, inclusive of the hair shaft, as a key element in senile hair graying, which does not exclusively affect follicle melanocytes. This new insight could open new strategies for intervention and reversal of the hair graying process.

  14. Contribution to the knowledge of the nervous system in the tentacles of some coelenterates (Anemonia sulcata, Metridium senile, Cerianthus membranaceus, Tealia felina and Hydra vulgaris)

    NARCIS (Netherlands)

    Marle, van J.

    1977-01-01

    The nervous system in the tentacles of the sea anemones Tealia felina, Anemonia sulcata, Metridium senile and Cerianthus membranaceus was studied using light microscopic and electron microscopic techniques. Because of the small dimensions of the nerve cells (6—7 µm) and of the neurites (diameter

  15. A study of chromium in human cataractous lenses and whole blood of diabetics, senile, and normal population.

    Science.gov (United States)

    Pineau, A; Guillard, O; Risse, J F

    1992-01-01

    Chromium (Cr) is of known biological importance, necessary for the maintenance of normal glucose metabolism. There is a lower level of blood Cr concentrations in cases of diabetes. Diabetes carries a risk of cataract development, so the potential effects of Cr on the eye may need to be studied in more depth. The presence of this trace element in both normal and cataractous human lenses has to our knowledge not been investigated so far. The concentration of total Cr in 61 human lenses and 38 blood samples was determined by electrothermal atomic absorption spectrometry with Zeeman effect (EAASZ). Analysis of the levels of Cr in human lenses shows a significant difference between normal and diabetic populations, and an absence of difference between senile and diabetic populations.

  16. A MULTIDISCIPLINARY APPROACH IN THE TREATMENT OF FRACTURES OF THE PROXIMAL FEMUR ON THE BACKGROUND OF SENILE OSTEOPOROSIS

    Directory of Open Access Journals (Sweden)

    N. V. Zagorodniy

    2016-01-01

    Full Text Available The article presents a review of published data on the problem of osteoporosis in patients older than 75 years who have had fractures of the proximal femur. We used descriptive and analytical methods. Search publications have done in accessible to free search databases. Based on our analysis, it was found: the majority of researchers in Russia and abroad are united in the opinion that this issue requires a multidisciplinary approach; surgical treatment should be initiated as early as possible after the onset of fracture, before the complications from side of the internal organs; patients with fractures on the background of senile osteoporosis should receive drugs that affect to the quantitative and qualitative components of bone.

  17. THE USAGE OF ORIGINAL COMPUTER PROGRAM FOR SCREENING OF SENILE ASTHENIA IN PRE- AND POST GRADUATE MEDICAL EDUCATION

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    Svetlana G. Gorelik

    2014-02-01

    Full Text Available The results of introduction of information technologies in educational process of medical students and students of postgraduate education were shown in the article. The actuality of material, which was outlined in the article, was caused by problems, which prevailed in the system of high education and by necessity of cooperation between practical health care and theoretical knowledge. For this aim the original «Computer program of optimization of care in geriatrics in dependence from degree of senile asthenia” was proposed. This program solved not only problems of qualitative alteration of informative environment of educational system but it contributed to increasing of effectiveness of knowledge’s mastering for increasing the quality of medical and social help to population.

  18. Synapsin I (protein I) in different brain regions in senile dementia of Alzheimer type and in multiinfarct dementia

    International Nuclear Information System (INIS)

    Adolfsson, R.; Alafuzoff, I.; Winblad, B.; Perdahl, E.; Albert, K.A.; Nestler, E.J.; Greengard, P.

    1984-01-01

    Synapsin I (Protein I), a neuron-specfic phosphoprotein enriched in presynaptic nerve terminals, has been used as a quantitative marker for the density of nerve terminals in five brain regions (caudate nucleus, cingulate gyrus, hippocampus, mesencephalon and putamen) from patients who had suffered from Alzheimer disease/senile dementia of Alzheimer type (AD/SDAT), from patients with multi-infarct dementia (MID), and from agematched controls. Samples were obtained at autopsy. Lower levels of Synapsin I were observed in the hippocampus of patients with AD/SDAT but not with MID. There were no significant differences in Synapsin I levels between patients and controls in any of the other four brain regions examined. (Author)

  19. [Association between metabolic syndrome and the 10 years mortality of cerebro-cardiovascular diseases in the senile population].

    Science.gov (United States)

    Jin, Meng-meng; Pan, Chang-Yu; Tian, Hui; Liu, Min; Su, Hai-yan

    2008-02-01

    To assess the prevalence of metabolic syndrome (MS) and its association with mortality of cerebro-cardiovascular diseases in senile population. Data were collected from 1926 people aged 60 and over, who took part in routine health examination in our hospital from 1996 to 1997. All subjects were followed up for 10 years. MS was diagnosed by using the definition recommended by Chinese Diabetic Society in 2004. Cox-proportional hazards models were used in survival analyses and to calculate the relative risk (RR) of cerebro-cardiovascular diseases mortality. The prevalence of MS was 25.03% (n = 482, Group 2) in this population. The 10 year mortality of cerebro-cardiovascular diseases was significantly higher (6.82/1000-person year vs. 2.55/1000-person year, P cerebro-cardiovascular diseases mortality was 2.52 (95% CI 1.367 - 4.661, P cerebro-cardiovascular diseases.

  20. A randomized, placebo-controlled, double-blind study to evaluate the efficacy of a citrus bioflavanoid blend in the treatment of senile purpura.

    Science.gov (United States)

    Berlin, Joshua M; Eisenberg, David P; Berlin, Mindy B; Sarro, Robert A; Leeman, Douglas R; Fein, Howard

    2011-07-01

    Senile purpura is a common, chronic skin condition affecting more than 10 percent of individuals over the age of 50. Despite being a benign condition, the continual development of purpura lesions in afflicted patients is frequently a source of significant visual and social concern. To date, there are no known effective treatments for this condition. To evaluate the efficacy of a novel nutraceutical citrus bioflavonoid blend in improving the skin's appearance in patients with senile purpura. A six-week, randomized, multicenter, placebo-controlled, double-blind study was conducted to determine whether a uniquely formulated, oral citrus bioflavonoid supplement could treat active lesions of senile purpura while preventing new lesions from arising. Seventy patients with senile purpura were enrolled and 67 completed the study. Subjects were randomized into two groups receiving either a citrus bioflavonoid blend or placebo medication, which was taken orally twice daily for six weeks. Clinical evaluations were performed by blinded investigators at two locations. A statistically significant reduction in the number of new purpura lesions in the skin area undergoing clinical study was documented. At the end of six weeks, the citrus bioflavonoid blend treated group showed a 50 percent reduction in purpura lesions from baseline. Patient self-assessment of the effectiveness of the medication echoed the results of an investigator global assessment with a statistically significant improvement in the skin's appearance noted by the patients receiving the active medication. No adverse effects were noted by either the patients or investigators. This new treatment appears to both safely and effectively diminish skin bruising in patients with senile purpura.

  1. Correlation of cognitive decline and behavioral changes in patients with presenile and senile onset Alzheimer’s disease

    Directory of Open Access Journals (Sweden)

    Pavlović D.M.

    2013-01-01

    Full Text Available Alzheimer’s disease (AD, the most prevalent dementia, is characterized not only by cognitive but also behavioral changes that pose the heaviest burden to caregivers. Differences in the clinical picture depending on the time of disease onset have been observed. We correlated cognitive and behavioral deficits in patients with presenile- and senile-onset AD to explore the differences. We tested 60 AD patients, 19 male and 41 female, mean age 65.2 years with the Dementia Behavior Disturbance Scale (DBD and a standard neuropsychological battery. The patients were divided according to their DBD score into two groups: group I - score 0-2 (n=24; 40%, group II - score 3≥ (n=36; 60%, comparable in disease duration and neurological findings. The cognitive scores were significantly higher in the group with less behavioral changes than in the group with more behavioral changes: Mini Mental State Examination score (p=0.0015, serial subtraction (p=0.0009, block design (p=0.0049, copy of complex figure (p=0.0125, complex visual organization (p=0.0099, divided attention, visual memory and speech comprehension. A significantly higher frequency of behavioral disturbances was registered in patients with senile onset than in the presenile-onset group (p<0.005. There were no sex differences. Our data show a correlation between cognitive decline and behavioral changes in late onset AD patients, indicating that more behavioral disturbances were associated with a more severe degree of cognitive decline, especially in non-verbal functions and attention deficits, compared to early onset patients. [Projekat Ministarstva nauke Republike Srbije, br. 175033 i br. 175022

  2. TREATMENT OUTCOMES IN ELDERLY AND SENILE PATIENTS WITH DEGENERATIVE DEFORMATIONS AND INSTABILITY OF THE SPINAL COLUMN

    Directory of Open Access Journals (Sweden)

    D. A. Mikhaylov

    2017-01-01

    Full Text Available Degenerative  scoliosis  is  a  prevalent  issue  among  the  aging  population.  Controversy  remains   over  the  role of surgical intervention in patients with such disease. The authors  present  the results of 14-year experience in treatment of this pathology.  Various approaches  to the surgical treatment depending  on the stage of the disease and the degree of deformation, including  decompression, instrumental posterior spinal fusion, anterior spinal fusion, and osteotomy were examined. Above treatment options are based on the analysis of clinical aspects, mechanical  stability of deformation, the degree of imbalance in the body and causes of pain or neurological  deficit.The  risk of postoperative complications is extremely  high and seems to be outweighed by the  possible successful outcomes of surgical treatment. The results presented in the treatment of degenerative scoliosis mainly provide positive outcomes and can assist in the selection of treatment for this group of patients.The purpose of the  study  is to  evaluate  the  treatment outcomes  of elderly  and  senile patients with  degenerative deformations and instability of the spinal column using various surgical techniques.Material and methods. During  the present  retrospective study the authors  analyzed 437 patients (337 (77% women and  100  (23%  men  aged  60 years  and  older  who  underwent surgical  treatment at  Russian  Research  institute of traumatology and orthopaedics named  after  R.R.Vreden between  2000 and 2016. The  study  group  included  patients with  diseases and consequences  of injuries  in the  spine, leading  to its deformation and following spinal stenosis  with development of neurological  deficit in some cases.The  patients were subdivided into  four  groups  depending  on surgical  procedure.  Patients in group  I underwent decompression  of neural  structures at affected

  3. Alendronate reduces the daily consumption of insulin (DCI) in patients with senile type I diabetes and osteoporosis.

    Science.gov (United States)

    Maugeri, D; Panebianco, P; Rosso, D; Calanna, A; Speciale, S; Santangelo, A; Rizza, I; Motta, M; Lentini, A; Malaguarnera, M

    2002-01-01

    The use of Alendronate for the treatment of senile diabetes with osteopenia or osteoporosis is a common practice today, although the reasons for the success of this treatment are not completely understood. We investigated 40 elderly female patients, over 70 years of age, divided in two Groups (A and B) 20 cases of each, with insulin-dependent senile diabetes and fair metabolic balance, with an average disease duration of 30 +/- 4 years. They all had osteoporosis shown by the mean T-score of bone mineral densitometry. The Groups were treated as follows, Group A with 10 mg/day of Alendronate per os, with morning fasting plus a supplementation of calcium and vitamin D3, while the Group B received only calcium and vitamin D3 per os. Bone mineral density (BMD) expressed in mg/cm2, and in terms of T-score and Z-score at the spine (L1-L4) was monitored over time after 12 and 24 months, using dexa technique with a Lunar DPX densitometer. Moreover, the variation of daily consumption of insulin (DCI) of all the study population was calculated 12 and 24 months after the start of treatments. The data of Group A showed an improvement of osteoporosis, as evidenced by the increase of BMD at both times of measurement, accompanied by a significant reduction in the DCI (-21.6% by the 12th month, and -36.2% by the end of the observation period). In the Group B only small, statistically insignificant changes were observed in both the BMD and DCI. The most plausible explanation of reduction of DCI in Group A seems to be that Alendronate has improved the clinical symptoms of osteoporosis (pain, rigidity, and reduction of movements) through its action on the bone mass recovery and slowing down the bone turnover and under these conditions the diabetic patients improved their own physical performance. The better and more extensive movements certainly produced a reduction in the DCI, since a correct and adequate physical activity does contribute to an improved glucose metabolism.

  4. Fouling community dominated by Metridium senile (Cnidaria: Anthozoa: Actiniaria in Bahía San Julián (southern Patagonia, Argentina

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    Juan Pablo Martin

    2015-06-01

    Full Text Available The objective of this study is to provide information about a harbour-fouling community dominated by Metridium senile in southern Patagonia. Several steel tubes from the wharf of Puerto San Julián were extracted to perform repair tasks, allowing the attached benthic community to be studied. Sampling was conducted at three levels: lower intertidal, 3-4 m depth and 6-7 m depth. In the lower intertidal, M. senile had a relative abundance of 43%, the most abundant accompanying species being Perumytilus purpuratus, Mytilus edulis platensis and Aulacomya atra atra. At subtidal level, the anemone showed relative abundances of 64% and 65%, and was accompanied by Monocorophium insidiosum at 3-4 m depth and by polychaetes of families Sabellidae and Syllidae at 6-7 m at depth. In the lower intertidal, epibiosis was more frequent on P. purpuratus, A. atra atra and M. edulis platensis, while in the subtidal, the richness of substrate-organisms increased significantly and the anemone was fixed to A. atra atra, M. edulis platensis, Paramolgula gregaria, Crepipatella dilatata, Austromegabalanus psittacus, Hiatella arctica, Polyzoa opuntia, Pyura sp. and Sabellidae tubes. The ability of M. senile to settle on many different organisms, along with other strategies, makes it a colonizer able to displace other species that could compete with it for substratum. Given the cosmopolitan nature of M. senile, the fact that this species has not been previously reported in the coastal zone of the region, and the results of our study, we discuss the possibility that this sea anemone is an invasive alien species in southern Patagonia, or at least a cryptogenic species.

  5. A Comparative Study of the Efficacy and Psychological States be¬tween Patients with Senile Ischemic Heart Failure Undergone ICU and Conventional Therapies

    OpenAIRE

    Changli DU

    2016-01-01

    Background: Our aim was to forward an effective therapeutic approach by comparing efficacy and psychological states between patients with senile ischemic heart failure undergone ICU and conventional therapies.Methods: We selected 64 patients from Hospital of Traditional Chinese Medicine of Rizhao (Shandong, China) between June 2013 and June 2014. The patients had ischemic heart disease, and were monitored for one-year time span. They were randomly divided into the experiment and control group...

  6. A Changing Healthcare System Model: The Effectiveness of Knowledge, Attitude, and Skill of Nursing Assistants Who Attend Senile Dementia Patients in Nursing Homes in Xi'an, China - A Questionnaire Survey

    Science.gov (United States)

    Cui, Yan; Fan, Rong; Wang, Yue-Min; Kaye, Aaron Joshua; Kaye, Alan David; Bueno, Franklin Rivera; Pei, Jian-Ming

    2014-01-01

    Background In 2010, China had an elderly population of 1.78 billion people. As in other societies around the world, China is facing a growing challenge in providing care for its elderly citizens. Ensuring the highest quality of care for elderly patients, many of whom have senile dementia, is directly related to the performance of nursing assistants. Methods With the goal of investigating the knowledge, attitudes, and skills of nursing assistants who care for senile dementia patients in nursing homes in Xi'an, China, we distributed a survey and analyzed the responses. Results Nursing assistants showed dedication and sincerity in their care for senile dementia patients. However, their performances in the categories of life nursing and mental nursing reveal room for improvement. Further, the nursing assistants did not display adequate knowledge about senile dementia. Based on survey results, the knowledge of the nursing assistants concerning nursing safety was comparatively adequate. Conclusion Nursing assistants who care for senile dementia patients in nursing homes in Xi'an, China, require further training that expands their knowledge and increases their capabilities. We recommend that nursing homes in Xi'an offer a standardized professional nurse/nurse assistant training course that focuses on care for elderly patients with senile dementia. PMID:25249797

  7. LONG-TERM THERAPY WITH INDAPAMIDE IN ELDERLY AND SENILE PATIENTS WITH HYPERTENSION: CARDIORENOPROTECTIVE EFFECTS AND INFLUENCE ON QUALITY OF LIFE

    Directory of Open Access Journals (Sweden)

    M. E. Statsenko

    2009-01-01

    Full Text Available Aim. To estimate cardiorenoprotective effect of 12-month therapy by indapamide in elderly and senile patients with arterial hypertension (HT and its influence on quality of life.Material and methods. 40 elderly and senile patients with HT were examined. 70% of patients received monotherapy by indapamide 2,5 mg once daily and 30% of patients were treated with indapamide and lisinopril combination. Duration of observation was 12 months. Ambulatory blood pressure (BP monitoring, echocardiography, plasma lipid profile, glycemia and uricemia levels and potassium serum level was evaluated initially and after 12 months of therapy. Glomerular filtration rate and albuminuria as well as patient quality of life also was evaluated.Results. Target BP level was reached in all patients during 12 month therapy. Reduction of average 24-hour, day and night BP, BP load, rate of morning BP rising was observed. Negative influence on BP variability was not found. Improvement of daily BP profile also was found. The indapamide reduced left ventricle mass, improved renal function, vessel resistance and quality of life. Negative influence of long-term therapy with indapamide on lipid, glucose, purine metabolism and serum potassium level was not observed.Conclusion. Indapamide is an effective antihypertensive drug for long-term treatment of elderly and senile patients with HT of 1-2 degree.

  8. [Effects of the nutritional education and dietary intervention on nutritional status and bone mineral density of middle-aged and senile patients with osteoporosis].

    Science.gov (United States)

    Zhao, Chunyan; Zhou, Ruihua; Tian, Yongzhi; Tang, Yongmei; Ning, Hongzhen; Liu, Haiyan

    2016-03-01

    To study the effect of the nutritional education and dietary intervention on nutritional status and bone mineral density (BMD) of middle-aged and senile patients with osteoporosis. Ninty middle-aged and senile osteoporosis patients were enrolled. They were randomly divided into two groups (intervention and control group) with 45 cases each. The control group was received conventional therapy and the intervention group added with nutritional education and dietary intervention for six months on the basis of conventional therapy. The methods of education and intervention included seminars, brochures distribution, dietary survey and individual guidance. The nutritional status and BMD were analyzed at the beginning and the end of the intervention respectively. After the intervention, the ratios of subjects whose intake of grain, vegetables, fruits, eggs, milk and beans in line with recommended intake of the intervention group were higher than those of the control group (P nutritional education and dietary intervention could promote middle-aged and senile patients' reasonable diet, improve their nutritional status, enhance bone mineral density and improve the effect of conventional therapy for osteoporosis.

  9. The Role of the Blood-Brain Barrier in the Pathogenesis of Senile Plaques in Alzheimer’s Disease

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    J. Provias

    2014-01-01

    Full Text Available The accumulation of beta-amyloid [Aβ] within senile plaques [SP] is characteristic of these lesions in Alzheimer’s disease. The accumulation of Aβ42, in particular, in the superior temporal [ST] cortex may result from an inability of the blood brain barrier (BBB to regulate the trans-endothelial transport and clearance of the amyloid. Lipoprotein receptor-related protein [LRP] and P-glycoprotein [P-gp] facilitate the efflux of Aβ out of the brain, whereas receptor for advanced glycation end products [RAGE] facilitates Aβ influx. Additionally, vascular endothelial growth factor [VEGF] and endothelial nitric oxide synthase [eNOS] may influence the trans-BBB transport of Aβ. In this study we examined ST samples and compared SP burden of all types with the capillary expression of LRP, p-gp, RAGE, VEGF, and e-NOS in samples from 15 control and 15 Alzheimer brains. LRP, P-gp, RAGE, VEGF, and eNOS positive capillaries and Aβ42 plaques were quantified and statistical analysis of the nonparametric data was performed using the Mann-Whitney and Kruskal-Wallis tests. In the Alzheimer condition P-gp, VEGF, and eNOS positive capillaries were negatively correlated with SP burden, but LRP and RAGE were positively correlated with SP burden. These results indicate altered BBB function in the pathogenesis of SPs in Alzheimer brains.

  10. Effect of rigid corneal contact lens and corneal limbal stem cell transplantation for senile patients with pterygium

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    Jiang Lu

    2017-06-01

    Full Text Available AIM: To investigate the effect of rigid contact lens in the treatment after pterygium excision and limbal stem cell transplantation in senile patients. METHODS: Totally 90 elderly patients diagnosed as unilateral pterygium in our hospital from March 2015 to March 2016 were selected and divided into two groups, observation group and control group, 45 case with 45 eyes in each group. Observation group was treated with limbal stem cell transplantation and rigid contact lens. Control group was treated with limbal stem cell transplantation only. The following indicators were observed and compared: corneal healing time, visual analogue score(VASat 1, 3, 5 and 7d after surgery and the recurrence rate of pterygium. RESULTS: The score on corneal irritation of observation group was significantly lower than that of control group(PPPP>0.05.CONCLUSION: Autologous corneal stem cell transplantation combined with rigid contact lens for pterygium in elderly patients is effective with shorter healing time and less pain, and it does not increase the recurrence rate.

  11. Cerebral blood flow and oxygen metabolism in senile dementia of Alzheimer's type and vascular dementia with deep white matter changes

    International Nuclear Information System (INIS)

    Tohgi, H.; Yonezawa, H.; Takahashi, S.; Sato, N.; Kato, E.; Kudo, M.; Hatano, K.; Sasaki, T.

    1998-01-01

    Regional cerebral blood flow (rCBF), cerebral metabolic rate of oxygen (rCMRO 2 ), oxygen extraction fraction (rOEF), and cerebral blood volume (rCBV) were investigated using positron emission tomography (PET) in 16 patients with senile dementia of Alzheimer's type (SDAT), and compared with those of 6 nondemented and 3 demented patients with deep white matter high signal (DWMH) on T2-weighted MRI and 6 controls. rCBF, rCMRO 2 and rCBV were determined using C 15 O 2 , 15 O 2 and C 15 O, respectively. rCBF and CMRO 2 were significantly decreased in the frontal, parietal and temporal cortex (P 2 was significantly reduced in only the frontal and temporal cortex of demented patients (P < 0.05). rOEF was significantly increased in the parietal cortex of patients with SDAT and in the white matter of patients with SDAT or DWMH (P < 0.05), and the increase in the frontal white matter significantly paralleled the progression of dementia in patients with SDAT (P < 0.05). rCBV was significantly decreased in the parietal and temporal cortex of patients with SDAT (P < 0.05), but not in any areas of those with DWMH. (orig.)

  12. Asymmetry of cerebral blood flow in patients with senile dementia of Alzheimer type by SPECT using I-123 IMP

    Energy Technology Data Exchange (ETDEWEB)

    Arai, Hisayuki; Hanyu, Haruo; Kobayashi, Yasutaka; Hatano, Nobuyoshi; Katsunuma, Hideyo; Suzuki, Takanari; Amino, Saburo (Tokyo Medical Coll. (Japan))

    1990-12-01

    Regional cerebral blood flow (rCBF) was determined by single photon emission CT (SPECT) with N-isopropyl-p-({sup 123}I)iodoamphetamine in 22 patients with clinically diagnosed senile dementia of Alzheimer type (SDAT) and in 18 age matched controls. We calculated asymmetry indices (AIs) of rCBF for matched right-left regions of interest. rCBF of parietal lobe in SDAT patients was significantly most laterally asymmetrycal, but the least in occipital lobe. Lateral asymmetry of rCBF in SDAT patients correlated with asymmetry of language and visuospatial functions; decreased rCBF in the left parietal lobe was associated with language dysfunction, and that in the right parietal lobe, with viduospatial dysfunction. Furthermore cerebellar AIs correlated negatively with those of the cerebral hemisphere and lower frontal region in SDAT patients. The results demonstrate that rCBF measurement by {sup 123}I-IMP SPECT is useful to detect lateral asymmetry in reduction of rCBF in SDAT. (author).

  13. Asymmetry of cerebral blood flow in patients with senile dementia of Alzheimer type by SPECT using I-123 IMP

    International Nuclear Information System (INIS)

    Arai, Hisayuki; Hanyu, Haruo; Kobayashi, Yasutaka; Hatano, Nobuyoshi; Katsunuma, Hideyo; Suzuki, Takanari; Amino, Saburo

    1990-01-01

    Regional cerebral blood flow (rCBF) was determined by single photon emission CT (SPECT) with N-isopropyl-p-[ 123 I]iodoamphetamine in 22 patients with clinically diagnosed senile dementia of Alzheimer type (SDAT) and in 18 age matched controls. We calculated asymmetry indices (AIs) of rCBF for matched right-left regions of interest. rCBF of parietal lobe in SDAT patients was significantly most laterally asymmetrycal, but the least in occipital lobe. Lateral asymmetry of rCBF in SDAT patients correlated with asymmetry of language and visuospatial functions; decreased rCBF in the left parietal lobe was associated with language dysfunction, and that in the right parietal lobe, with viduospatial dysfunction. Furthermore cerebellar AIs correlated negatively with those of the cerebral hemisphere and lower frontal region in SDAT patients. The results demonstrate that rCBF measurement by 123 I-IMP SPECT is useful to detect lateral asymmetry in reduction of rCBF in SDAT. (author)

  14. Descrição da qualidade vocal de personagens idosos dos filmes de Hollywood Vocal quality description of senile characters from Hollywood movies

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    Gisele Oliveira

    2010-06-01

    Full Text Available OBJETIVO: descrever a qualidade vocal de personagens idosos dos filmes de Hollywood. MÉTODOS: foram colhidas 50 amostras de fala de personagens idosos, 11 do sexo feminino e 39 do masculino, de 38 filmes hollywoodianos dos anos de 1993 a 2001. Através da análise perceptivo-auditiva das amostras de fala, 20 fonoaudiólogos treinados classificaram cada personagem em idoso e não idoso, além de avaliarem as vozes quanto aos seguintes parâmetros citados pela literatura como mais alterados: rouquidão, crepitação, soprosidade, tensão, aspereza, astenia, nasalidade, tremor, modulação, pitch e estabilidade da frequência fundamental. RESULTADOS: após a análise perceptivo-auditiva, foi observado que a grande maioria dos atores (82% utilizou voz de idoso para representar seus papéis. O marcador mais evidente nas vozes foi alteração na qualidade vocal (92%, demonstrada por crepitação (80%, soprosidade (54%, tensão (38%, rouquidão (30% e astenia (28%. O segundo marcador mais utilizado pelos atores nas suas representações foi a modulação vocal ampla e variada (44%. Também foram observadas alterações no controle da voz (36% e instabilidade da frequência fundamental (38%. CONCLUSÃO: a partir dos resultados obtidos pode-se concluir que os filmes de Hollywood caracterizam o idoso através de desvios evidentes na qualidade e modulação da voz, utilizando tipos de vozes alteradas e modulação vocal ampla e instável.PURPOSE: to describe the vocal quality of Hollywood movies characters playing elderly people roles. METHODS: a total of 50 aged character voice samples were used, 11 female and 39 male, from 38 Hollywood movies from the period between 1993 and 2001. Twenty speech therapists performed a perceptual auditory analysis. The listener's task required classifying each character either as elderly or as adult by their speech features, and also assessing their voices following the parameters that are most frequently addressed in the

  15. NELL-1 Injection Maintains Long-Bone Quantity and Quality in an Ovariectomy-Induced Osteoporotic Senile Rat Model

    Science.gov (United States)

    Kwak, Jinny; Zara, Janette N.; Chiang, Michael; Ngo, Richard; Shen, Jia; James, Aaron W.; Le, Khoi M.; Moon, Crystal; Zhang, Xinli; Gou, Zhongru; Ting, Kang

    2013-01-01

    Over 10 million Americans have osteoporosis, and is the predominant cause of fractures in the elderly. Treatment of fractures in the setting of osteoporosis is complicated by a suboptimal bone regenerative response due to a decline in the number of osteoblasts, their function, and survival. Consequently, an osteogenic therapeutic to prevent and treat fractures in patients with osteoporosis is needed. Nel-like molecule-1 (NELL-1), a novel osteoinductive growth factor, has been shown to promote bone regeneration. In this study, we aim to demonstrate the capacity of recombinant NELL-1 to prevent ovariectomy (OVX)-induced osteoporosis in a senile rat model. Ten-month-old female Sprague-Dawley rats underwent either sham surgery or OVX. Subsequently, 50 μL of 600 μg/mL NELL-1 lyophilized onto a 0–50-μm tricalcium phosphate (TCP) carrier was injected into the femoral bone marrow cavity while phosphate-buffered saline (PBS) control was injected into the contralateral femur. Our microcomputed tomography results showed that OVX+PBS/TCP control femurs showed a continuous decrease in the bone volume (BV) and bone mineral density (BMD) from 2 to 8 weeks post-OVX. In contrast, OVX+NELL-1/TCP femurs showed resistance to OVX-induced bone resorption showing BV and BMD levels similar to that of SHAM femurs at 8 weeks post-OVX. Histology showed increased endosteal-woven bone, as well as decreased adipocytes in the bone marrow of NELL-1-treated femurs compared to control. NELL-1-treated femurs also showed increased immunostaining for bone differentiation markers osteopontin and osteocalcin. These findings were validated in vitro, in which addition of NELL-1 in OVX bone marrow stem cells resulted in increased osteogenic differentiation. Thus, NELL-1 effectively enhances in situ osteogenesis in the bone marrow, making it potentially useful in the prevention and treatment of osteoporotic fractures. PMID:23083222

  16. Glucose-6-phosphate dehydrogenase (G6PD) deficiency and senile cataract in a Sardinian male population, Italy.

    Science.gov (United States)

    Pinna, Antonio; Pes, Adele; Zinellu, Angelo; Carta, Arturo; Solinas, Giuliana

    2009-01-01

    There is still no general agreement on the role of G6PD deficiency in the pathogenesis of cataract. The purpose of this study was to determine the prevalence of G6PD deficiency in men with senile cataract from Northern Sardinia, Italy, and to compare it with the prevalence rate of G6PD deficiency in the general population of the same area. G6PD activity was determined by using a quantitative method. G6PD blood levels were measured in 1,620 men with cataract. The control group consisted of 1,646 apparently healthy male subjects from the same area. All patients were of Sardinian origin. The Z or Student's t test was used, when appropriate, to determine differences between groups. The odds ratio (OR) with 95% confidence interval was used to evaluate the association between age-related cataract and G6PD deficiency. G6PD deficiency was found in 133 (8.2%) out of 1,620 patients with cataract and in 120 (7%) out of 1,646 control subjects. Differences in G6PD prevalence between cataract patients and controls were not statistically significant (P=0.64). There was no age-related statistical difference between G6PD deficient and normal patients with cataract. No statistically significant association between age-related cataract and G6PD deficiency was found (OR=1.14; 95% confidence interval: 0.88-1.47). The results of this large study suggest that male patients with G6PD deficiency in the Sardinian population do not have a higher risk of developing presenile cataract. G6PD deficiency does not represent a pathogenetic factor for early cataract formation, at least not in the Northern part of Sardinia.

  17. Effect Of Using Black Cumin (Nigella Sativa) As Natural Antioxidant On Hyperlipidaemia And Antioxidant Activities In Senile Rats

    International Nuclear Information System (INIS)

    HAMZA, R.G.; MAHMOUD, K.A.

    2009-01-01

    The black cumin (Nigella sativa) is one of the important herbal plants that used widely in most of human diseases and food preservation. Chemical composition of irradiated black cumin (10 kGy); moisture, ash, crude protein, crude lipid, total carbohydrate and crude fiber, were evaluated. The GC for analysis of fatty acids showed that the number of identified fatty acids was 9; the important one was linoleic (natural antioxidant). GC/MS used for analysis of essential oil showed that the number of identified compounds was 16; the important ones were thymoquinone, eugenol and linalool (natural antioxidants). Also, this study was performed to examine the efficacy of the black cumin to ameliorate the induced hyperlipidemia in senile rats. Twenty eight male rats were equally and randomly categorized into four groups. High fat diet (20g fat / 100g diet) was daily administered to rats for 6 weeks. Other animals where fed daily on either raw or irradiated black cumin diet (1% w/w) for 6 weeks. The results revealed that high fat diet fed to rats significantly induced an increase in serum phospholipids, TG, TC, LDL-C, atherogenic index and lipid peroxides (MDA). Significant decrease was observed in HDL-C, blood antioxidant enzymes activity (superoxide dismutase and catalase) and concentration of reduced glutathione (GSH). The results obtained revealed that feeding rats on diet containing either raw or irradiated black cumin (1% w/w) induced significant improvement in the above mentioned parameters. There was non- significant difference between non-irradiated and irradiated black cumin. Moreover, supplementation of black cumin in diet of rats can offer protection against free radicals generated through oxidative stress as a consequence of hyperlipidemic food.

  18. Clinical efficacy comparison of flabby skin excision combined orbicularis oculi muscle shortening surgery in patients with senile entropion

    Directory of Open Access Journals (Sweden)

    Qing-Liang Xu

    2015-07-01

    Full Text Available AIM: To observe the clinical effect of slack skin excision combined with orbicularis oculi muscle shortening and orbicularis muscle shortening in the treatment of elderly patients with lower eyelid entropion, and provide the reference for the clinical treatment.METHODS: Eighty-two(126 eyesclinical diagnosis's elderly patients with lower eyelid entropion were collected from our department, then randomly divided into excised relaxing skin and orbicularis oculi muscle shortening treatment group and the orbicularis muscle shortening treatment group.The general data of the two groups, long term curative effect and short-term curative effect were compared. RESULTS: The age, sex, proportion of patients with the first time operation, course of disease were no statistical significance between the observation group and the control group(P>0.05. The short-term effective rate of the observation group was 95.2%, while the short-term effective rate of the control group was 77.8%, the short-term efficiency differences between the two groups was statistical significance(χ2=4.100, P=0.043. The long-term cure rate of the observation group was 82.5%(34 cases, 52 eyes, recurrence rate was 17.5%(7 cases, 11 eyes, while the cure rate of the control group was 60.3%(25 cases, 38 eyes, recurrence rate was 39.7%(16 cases, 25 eyes, the difference of long term cure rate was statistical significance between the two groups(PCONCLUSION: The clinical curative effect of slack skin excision combined with orbicularis oculi muscle shortening in the treatment of senile inferior entropion is better than orbicularis muscle shortening operation, recommending application in the clinical.

  19. [Optical coherence tomography in eyes with senile retinoschisis : SD-OCT versus ultrasound examinations and assessment of the vitreoretinal interface].

    Science.gov (United States)

    Bringewatt, A; Burzer, S; Feucht, N; Maier, M

    2017-05-15

    In addition to ocular ultrasonography (US), spectral domain optical coherence tomography (SD-OCT) is available in order to diagnose senile retinoschisis (sRS). SD-OCT also allows for classification of posterior vitreous detachment (PVD) in healthy eyes. Reevaluation of the value and additional benefit of both imaging procedures. SD-OCT-based evaluation of PVD stages in sRS patients. Diagnostic results of 33 eyes in 26 patients with clinical suspicion of sRS were retrospectively analysed. All patients received a SD-OCT and a 10 MHz US examination of the region of interest (RoI). In 32 eyes the PVD stage was classified by SD-OCT using the description by Uchino et al. The vitreous position in peripheral SD-OCT scans with sRS was reviewed. SD-OCT confirmed sRS in 29 eyes. US examination identified sRS in 26 eyes. In 11 eyes, the examination results of the two methods differed. In 7 eyes sRS was identified by SD-OCT but not by US examination. US examination confirmed sRS in 4 eyes for which SD-OCT scans were not useful. Most cases of sRS were detected in temporal located retinal lesions. There was no significant difference between the results of both imaging procedures regarding the RoI (p = 0.64). SD-OCT provided additional information in 27 eyes. Four eyes did not present PVD. Early and intermediate stages of PVD were detected in 9 eyes, while 19 eyes showed complete PVD. In most cases, the vitreous could not be identified in the SD-OCT scans of the periphery. In clinical practice, neither SD-OCT nor US ensure an explicit finding of sRS in each eye with sRS. However, both methods positively complement one another and together they improve image-based diagnosis. All stages of PVD may be found in eyes with sRS. The contribution of the vitreous to the pathogenesis of sRS remains uncertain.

  20. Alterações do segmento posterior na microftalmia: relato de casos Posterior segment changes in microphthalmic eyes: case report

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    Fernando José De Novelli

    2009-10-01

    Full Text Available Microftalmia é a alteração de desenvolvimento caracterizada pela redução do tamanho do bulbo ocular. Pode estar associada a manifestações estruturais do segmento anterior e posterior. As alterações mais comuns do segmento anterior são as opacidades corneanas, o estreitamento e fechamento do ângulo da câmara anterior e a catarata, e as mais frequentes no segmento posterior são a efusão uveal, as dobras de retina, a alteração da vascularização capilar macular, a ausência de depressão foveal e a retinosquise periférica. Este estudo descreve o caso de três pacientes com microftalmo e manifestações no segmento posterior documentadas com tomografia de coerência óptica. O primeiro caso apresentou a síndrome de efusão uveal, com descolamento de coróide e de retina, tratada com cirurgia de esclerectomia parcial nos quatro quadrantes. No segundo caso, havia a dobra retiniana neurossensorial na fóvea e feixe papilomacular em ambos os olhos sem o envolvimento de epitélio pigmentado retiniano e coriocapilar. No terceiro paciente, o microftalmo estava acompanhado de ausência da depressão foveal, cujo principal diagnóstico diferencial é a hipoplasia foveal.Microphthalmos is a developmental ocular disorder defined as a small eyeball. The condition can be associated with abnormalities of anterior and posterior segments. The most common anterior characteristics include corneal opacities, angle-closure and a shallow anterior chamber and cataract. The main findings of posterior segment are uveal effusion, retinal folds, abnormalities of macular capillar vascularization, absence of foveal depression and peripheral retinoschisis. Three patients with microphthalmos were assisted and their OCT features of posterior segment were analyzed. The first case had uveal effusion syndrome, choroidal and retinal detachment treated with parcial sclerectomy at the four quadrants. The other case presented with neurosensory retinal fold at fovea

  1. [Ginkgo extract in impaired vision--treatment with special extract EGb 761 of impaired vision due to dry senile macular degeneration].

    Science.gov (United States)

    Fies, P; Dienel, Angelika

    2002-01-01

    The therapeutic efficacy of Ginkgo special extract Egb 761 was investigated in a controlled, double-blind trial involving 99 patients with impaired vision due to senile, dry macular degeneration. The primary objective target variable was the change in the corrected visual acuity of the more severely impaired eye at baseline, during a six months treatment period with either 240 mg/die (group I = 50 patients) or 60 mg/die (group II = 49 patients) Egb 761. Marked improvement of the study participants' vision was observed in both treatment groups already after four weeks, with more pronounced improvements in group I (acuity increases by 0.13 in group I vs. 0.10 in group II after 24 weeks). The fraction of patients with improvement of visual acuity > or = 0.2 was nearly twice as large in the group treated with 240 mg/die Egb 761 as in patients receiving the lower dosage (p = 0.08). Subjective health impairments, if present, could be improved during treatment as well. The investigator rated a favorable tolerability for both dosages of Egb 761. In conclusion, the results demonstrate the therapeutic efficacy of Egb 761 in patients with senile, dry macular degeneration, with obvious benefits in every-day life.

  2. Effectiveness and safety of celecoxib combined with diacerein in the treatment of senile degenerative knee osteoarthritis: study protocol and preliminary results of a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Guo-dong Wang

    2017-01-01

    Full Text Available Background and objectives: The non-steroidal anti-inflammatory drug celecoxib, used for the treatment of senile degenerative knee osteoarthritis, has a rapid onset of action and few side effects. However, it cannot prevent the occurrence and development of knee osteoarthritis. Celecoxib withdrawal is likely to induce a rebound increase in inflammation that may aggravate symptoms. Diacerein is a drug used to improve articular cartilage metabolism. It can delay the progression of senile degenerative knee osteoarthritis, but has a slow onset of action. Whether combined treatment with celecoxib and diacerein provides complimentary actions to achieve a better therapeutic effect on senile degenerative knee osteoarthritis remains unclear. >Design: A prospective, single-center, randomized controlled trial. Methods: Three hundred patients with senile degenerative knee osteoarthritis who receive treatment at the Department of Orthopedics, Second Affiliated Hospital of Nanjing Medical University, China will be randomly assigned to the celecoxib (200 mg, once a day, orally, diacerein (50 mg, twice a day, orally, and celecoxib + diacerein (celecoxib 200 mg, once a day, orally and diacerein 50 mg, twice a day, orally groups, with 100 patients in each group. Patients in each group will be treated for 12 successive weeks, and a 36-week follow-up will be performed. At 24 weeks after treatment, the VAS score for pain during the 20-meter walk test and osteoarthritis index were significantly decreased in the diacerein and celecoxib + diacerein groups compared to pre-treatment (P Outcome measures and preliminary results: The primary outcome measure of this study is the Visual Analogue Scale (VAS score for pain during the 20-meter walk test before and 1, 4, 12, 24, and 36 weeks after treatment. The secondary outcome measures of this study include osteoarthritis index and X-ray image findings of the knee before and 1, 4, 12, 24, and 36 weeks after treatment, as well

  3. 99mTc-HMPAO-SPECT in the diagnosis of senile dementia of Alzheimer's type - a study under clinical routine conditions

    International Nuclear Information System (INIS)

    Stoppe, G.; Staedt, J.; Schuetze, R.; Kunert, H.J.; Ruether, E.; Koegler, A.; Sandrock, D.; Emrich, D.

    1995-01-01

    This study was designed to evaluate whether investigations of cerebral blood flow can be a helpful diagnostic tool in the differential diagnosis between (senile) dementia of Alzheimer's type [(S)DAT] and geriatric depression with cognitive impairment. Under clinical routine conditions we performed Single Photon Emission Computed Tomography (SPECT) using 99m Tc-Hexamethylpropyleneamine Oxime (HMPAO) in 23 patients with (S)DAT (14 f, 9 m; mean age 68.9 y), 17 patients with geriatric depression (9 f, 8 m; mean age 66.4 y) and 12 age-matched controls (9 f, 3 m; mean age 69.2 y). Semiquantitative analysis (corticocerebellar ratios) of eight different regions of interest (ROI) revealed a significantly ( p 99m Tc-HMPAO SPECT is a valuable additional tool in the differential diagnosis of depression and dementia in the elderly. (author)

  4. Xenon contrast CT-CBF scanning of the brain differentiates normal age-related changes from multi-infarct dementia and senile dementia of Alzheimer type

    International Nuclear Information System (INIS)

    Tachibana, H.; Meyer, J.S.; Okayasu, H.; Shaw, T.G.; Kandula, P.; Rogers, R.L.

    1984-01-01

    Local cerebral blood flow (LCBF) and partition coefficients (L lambda) were measured during inhalation of stable xenon gas with serial CT scanning among normal volunteers (N . 15), individuals with multi-infarct dementia (MID, N . 10), and persons with senile dementia of Alzheimer type (SDAT, N . 8). Mean gray matter flow values were reduced in both MID and SDAT. Age-related declines in LCBF values in normals were marked in frontal cortex and basal ganglia. LCBF values were decreased beyond normals in frontal and temporal cortices and thalamus in MID and SDAT, in basal ganglia only in MID. Unlike SDAT and age-matched normals, L lambda values were reduced in fronto-temporal cortex and thalamus in MID. Multifocal nature of lesions in MID was apparent. Coefficients of variation for LCBFs were greater in MID compared with SDAT and/or age-matched normals

  5. [An investigation of the efficacy of invasive-noninvasive sequential mechanical ventilation in senile patients with severe community-acquired pneumonia].

    Science.gov (United States)

    Guo, Fengying; Xu, Sicheng; Liu, Guangming; Wang, Xiuyan

    2015-07-01

    To investigate the efficacy of invasive-noninvasive sequential mechanical ventilation (MV) in senile patients with severe community-acquired pneumonia (CAP). A prospective study was conducted. The patients with severe CAP aged ≥75 years admitted to Department of Respiratory Intensive Care Unit (RICU) of the First Affiliated Hospital of Xinjiang Medical University from November 2012 to July 2014, with refusal to have tracheostomy, were enrolled. All patients meeting the diagnostic criteria of CAP and severe CAP were first admitted into the Department of Emergency, and they were found to need MV without absolute contraindication for noninvasive ventilation (NIV) in RICU. The patients were mechanically ventilated via endotracheal intubation (ETI), and they were randomly divided into invasive-noninvasive sequential MV group (sequential MV group) and conventional MV group. NIV was initiated immediately when patients matched the conditions for early extubation in the sequential MV group. Oxygen therapy (5 L/min) via a Venturi mask was provided when the indications of conventional extubation were met. The baseline data and clinical characteristics were recorded, the risk factors of death were analyzed by logistic regression analysis, and 60-day survival rate was analyzed by Kaplan-Meier curve. Ninety-one senile patients with severe CAP were enrolled, among them 28 patients died within 60 days, with a mortality rate of 30.77%. No significant difference in 60-day mortality was found between sequential MV group (n=44) and conventional MV group [n=47, 25.0% (11/44) vs. 36.2% (17/47), χ2=1.331, P=0.249]. In the sequential MV group, the incidence of ventilator-associated pneumonia (VAP) was significantly decreased [27.3% (12/44) vs. 55.3% (26/47), χ2=7.350, P=0.007], and the rate of ETI≥2 times was increased [59.1% (26/44) vs. 29.8% (14/47), χ2=5.095, P=0.024] as compared with conventional MV group. Compared with survival group, the patients in non-survival group showed

  6. Cyperenoic acid suppresses osteoclast differentiation and delays bone loss in a senile osteoporosis mouse model by inhibiting non-canonical NF-κB pathway.

    Science.gov (United States)

    Chawalitpong, Supatta; Chokchaisiri, Ratchanaporn; Suksamrarn, Apichart; Katayama, Shigeru; Mitani, Takakazu; Nakamura, Soichiro; Athamneh, Ahmad Ai; Ritprajak, Patcharee; Leelahavanichkul, Asada; Aeimlapa, Ratchaneevan; Charoenphandhu, Narattaphol; Palaga, Tanapat

    2018-04-04

    Cyperenoic acid is a terpenoid isolated from the root of a medicinal plant Croton crassifolius with a wide range of biological activities. In this study, the effects of cyperenoic acid on osteoclast differentiation were investigated both in vitro and in vivo using receptor activator of nuclear factor-κB ligand (RANKL)-induced bone marrow-derived osteoclasts and senescence-accelerated mouse prone 6 (SAMP6). Cyperenoic acid significantly suppressed RANKL-induced osteoclast differentiation at the concentrations with no apparent cytotoxicity. The half maximum inhibitory concentration (IC 50 ) for osteoclast differentiation was 36.69 μM ± 1.02. Cyperenoic acid treatment evidently reduced the expression of two key transcription factors in osteoclast differentiation, NFATc1 and c-Fos. Detailed signaling analysis revealed that cyperenoic acid did not affect MAPK pathways and canonical NF-κB pathway but impaired activation of p100/p52 in the non-canonical NF-κB pathway upon RANKL stimulation. Moreover, the expression of osteoclast-related genes, nfatc1, ctsk, irf8, acp5 and cfos were disrupted by cyperenoic acid treatment. The bone resorption activity by cyperenoic acid-treated osteoclasts were impaired. In a senile osteoporosis mouse model SAMP6, mice fed on diet supplemented with cyperenoic acid showed delay in bone loss, compared to the control. Taken together, plant-derived cyperenoic acid shows great potential as therapeutic agent for osteoporosis.

  7. Binding of curcumin to senile plaques and cerebral amyloid angiopathy in the aged brain of various animals and to neurofibrillary tangles in Alzheimer's brain.

    Science.gov (United States)

    Mutsuga, Mayu; Chambers, James Kenn; Uchida, Kazuyuki; Tei, Meina; Makibuchi, Takao; Mizorogi, Tatsuya; Takashima, Akihiko; Nakayama, Hiroyuki

    2012-01-01

    The binding of curcumin to senile plaques (SPs) and cerebral amyloid angiopathy (CAA) was examined in the aged brain of various animal species and a human patient with Alzheimer's disease (AD), together with its binding to neurofibrillary tangles (NFTs). Brain sections were immunostained with anti-amyloid β protein 1-42 (Aβ42) and anti-amyloid β protein 1-40 (Aβ40) antibodies. These sections were also stained with alkaline Congo red, periodic acid-methenamine silver (PAM), and curcumin (0.009% curcumin solution) with or without formic acid pretreatment. The sections from the AD brain were also immunostained for anti-paired helical filament-tau (PHF-tau), and were stained with Gallyas silver for NFTs. Some SPs in the AD, monkey, dog, bear, and amyloid precursor protein transgenic mouse (APP Tg-mouse) brains contained congophilic materials, and were intensely positive for curcumin. In addition, curcumin labeled some diffuse SPs negative for Congo red in the AD, monkey, bear, and APP Tg-mouse brains. In all animals, CAA was intensely positive for both Congo red and curcumin. The specific curcumin staining activity was lost by formic acid pretreatment. In the AD brain, NFTs positive for PHF-tau and Gallyas silver were moderately stained with curcumin. These findings indicate that curcumin specifically binds to the aggregated Aβ molecules in various animals, and further to phosphorylated tau protein, probably according to its conformational nature.

  8. [Effect of modified huanglian wendan decoction in treating senile patients with mild cognitive impairment of turbid-phlegm blocking orifice syndrome].

    Science.gov (United States)

    Guo, Ren-zhen; Zhou, Wen-quan; Luo, Zeng-gang

    2010-01-01

    To observe the clinical efficacy of modified Huanglian Wendan Decoction (HWD) in treating senile mild cognitive impairment (MCI) of turbid-phlegm blocking orifice syndrome. With a block randomized, double-blinded and controlled design adopted, the 64 patients of MCI selected from December 2007 to February 2009 were randomly and equally assigned to two groups. The treatment group was treated with HWD in dose of 200 mL, twice a day; the control group was given Aniracetam 0.2 g (for patients over 70-years-old, 0.1 g) three times a day. And the illusive medicine in dosage-form of capsule/decoction simulated to that used in the opposite group was applied. The medication and observation lasted for three months. Chinese medicine syndrome, cognition capacity (by MMSE), laboratory indexes [acetylcholine (Ach), superoxide dismutase (SOD), malondialdehyde (MDA)] and safety related indexes in patients were observed. After treatment, MMSE score increased in both groups, but the increment in the treatment group was significantly higher than that in the control group (PAniracetam; and with effects for raising SOD activity and reducing MDA level similar to those of Aniracetam.

  9. Regional cerebral blood flow and its correlation with clinical assessment in senile dementia of Alzheimer type and multi-infarct dementia

    International Nuclear Information System (INIS)

    Shinohara, Masao; Kawakatsu, Shinobu; Morinobu, Shigeru; Oiji, Arata; Sagawa, Katsuo; Yazaki, Mitsuyasu; Totsuka, Shirou; Komatani, Akio; Yamaguchi, Koichi

    1989-01-01

    Twenty-one patients with senile dementia of Alzheimer type (SDAT), 11 patients with multi-infarct dementia (MID), and 6 healthy volunteers were examined by SPECT using Xe-inhalation method. These patients also underwent an intelligence test according to the Gottfries-Brane-Steen (GBS) scale. Patients with mild SDAT did not have a significantly decreased regional cerebral blood flow (rCBF). In moderate or severe cases, however, a significantly decreased rCBF was bilaterally observed in all regions, except for the basal ganglia. This was marked in the temporoparietal region. A group of moderate or severe MID patients had a significantly decreased rCBF especially in the basal ganglia. It was also observed in the temporoparietal region, but not in the frontal region. Among the SDAT patients, there was a good correlation between rCBF and GBS scale in all the regions, except for the basal ganglia. In the case of MID patients, correlations were observed both between rCBF in the left side of the brain and clinical findings according to the method of Hasegawa and between rCBF in the right side of the frontal region and the motor function on the GBS scale. These findings may have implications for the different pathophysiology between SDAT and MID. (N.K.)

  10. Quantification of microangiopathic lesions in brain parenchyma and age-adjusted mean scores for the diagnostic separation of normal from pathological values in senile dementia

    International Nuclear Information System (INIS)

    Hentschel, F.; Kreis, M.; Damian, M.; Krumm, B.; Froelich, F.

    2005-01-01

    Purpose: to quantify microangiopathic lesions in the cerebral white matter and to develop age-corrected cut-off values for separating normal from dementia-related pathological lesions. Materials and methods: in a memory clinic, 338 patients were investigated neuropsychiatrically by a psychological test battery and by MRI. Using a FLAIR sequence and a newly developed rating scale, white matter lesions (WMLs) were quantified with respect to localization, number and intensity, and these ratings were condensed into a score. The WML scores were correlated with the mini-mental state examination (MMSE) and clinical dementia rating (CDR) score in dementia patients. A non-linear smoothing procedure was used to calculate age-related mean values and confidence intervals, separate for cognitively intact subjects and dementia patients. Results: the WML scores correlated highly significantly with age in cognitively intact subjects and with psychometric scores in dementia patients. Age-adjusted WML scores of cognitively intact subjects were significantly different from those of dementia patients with respect to the whole brain as well as to the frontal lobe. Mean value and confidence intervals adjusted for age significantly separated dementia patients from cognitively intact subjects over an age range of 54 through 84 years. Conclusion: a rating scale for the quantification of WML was validated and age-adjusted mean values with their confidence intervals for a diagnostically relevant age range were developed. This allows an easy to handle, fast and reliable diagnosis of the vascular component in senile dementia. (orig.)

  11. Studies of cerebral blood flow and metabolism in patients with senile dementia of the Alzheimer's type and diagnostic evaluation of the dementing illnesses by positron emission tomography

    International Nuclear Information System (INIS)

    Sakamoto, Shizuki

    1990-01-01

    This study was designed to determine cerebral dysfunction in senile dementia of the Alzheimer's type (SDAT). Regional cerebral blood flow (rCBF), oxygen extraction fraction and cerebral oxygen consumption (rCMRO 2 ) were studied in SDAT patients (n=16) and age-matched normal elderly people (n=5) by positron emission tomography (PET) using the O-15 labeled CO 2 and O 2 inhalation technique. The SDAT group had a significantly lower values in both rCBF and rCMRO 2 than the normal control. During the early stage of SDAT, rCMRO 2 was restricted to the temporal cortex; and it extended to the parietal and frontal cortices associated with a decreased rCBF as the disease progressed. Posterior temporal and posterior parietal association cortices were considered to be the most damageable part during the early stage. Bilateral differences in oxygen metabolism of the temporal and parietal cortices tended to be in accordance with clinical symptoms for disturbed speech and visuospatial function, suggesting the correlation between rCMRO 2 and rCBF in SDAT. Findings of PET in SDAT differed from those obtained in each patient with multi-infarct dementia or Pick disease, in that both rCBF and rCMRO 2 were inhomogeneously decreased over the whole cerebral cortex for multi-infarct dementia and in that homogeneously decreased rCBF and rCMRO 2 were restricted to the frontal and temporal cortices for Pick disease. PET may have a potential for differentiating various types of dementia. (N.K.)

  12. Concomitant detection of beta-amyloid peptides with N-terminal truncation and different C-terminal endings in cortical plaques from cases with Alzheimer's disease, senile monkeys and triple transgenic mice.

    Science.gov (United States)

    Härtig, Wolfgang; Goldhammer, Simone; Bauer, Ute; Wegner, Florian; Wirths, Oliver; Bayer, Thomas A; Grosche, Jens

    2010-09-01

    The disturbed metabolism of beta-amyloid peptides generated from amyloid precursor protein is widely considered as a main factor during the pathogenesis of Alzheimer's disease. A neuropathological hallmark in the brains from cases with Alzheimer's disease are senile plaques mainly composed of hardly soluble beta-amyloid peptides comprising up to 43 amino acids. Age-dependent cortical beta-amyloidosis was also shown in several transgenic mice and old individuals from various mammalian species, e.g., non-human primates. Beta-amyloid(1-42) is believed to be the main component in the core of senile plaques, whereas less hydrophobic beta-amyloid(1-40) predominantly occurs in the outer rim of plaques. Amino-terminally truncated pyroglutamyl-beta-amyloid(pE3-x) was recently found to be a beta-amyloid species of high relevance to the progression of the disease. While a few biochemical studies provided data on the co-occurrence of several beta-amyloid forms, their concomitant histochemical detection is still lacking. Here, we present a novel triple immunofluorescence labelling of amino- and differently carboxy-terminally truncated beta-amyloid peptides in cortical plaques from a case with Alzheimer's disease, senile macaques and baboons, and triple transgenic mice with age-dependent beta-amyloidosis and tau hyperphosphorylation. Additionally, beta-amyloid(pE3-x) and total beta-amyloid were concomitantly detected with beta-amyloid peptides ending with amino acid 40 or 42, respectively. Simultaneous staining of several beta-amyloid species reveals for instance vascular amyloid containing beta-amyloid(pE3-x) in Alzheimer's disease and monkeys, and may contribute to the further elucidation of beta-amyloidosis in neurodegenerative disorders and animal models. 2010 Elsevier B.V. All rights reserved.

  13. [Psychosocial risk factors involved in progressive dementia-associated senility among the elderly residing at home. AGES project--three year cohort longitudinal study].

    Science.gov (United States)

    Takeda, Tokunori; Kondo, Katsunori; Hirai, Hiroshi

    2010-12-01

    This study aimed to identify psychosocial risk factors involved in the progression of senility associated with dementia, and clarify activities that may prevent such progression. In 2003, as a part of the Aichi Gerontological Evaluation Study Project, a self-completion postal questionnaire survey was conducted among elderly persons aged 65 years or older not under the Certification of Eligibility for Long-Term Care (hereafter, Certification); (response rate: 49.4%). Among the respondents, 9,720 subjects (4,614 males, 5,106 females; average age 72.8 years, range +/- 6.0), whose gender and age were confirmed and who could handle all ADLs independently, were selected for the three-year longitudinal study. The end point of the study was Certification in the second appraisal, through categorization under the ADL Independence Assessment Criteria for the Elderly with Dementia Rank II. Predictive variables used in the study were: health behavior, psychological/ cognitive factors, recreational/social activities, TMIG Index of Competence, and social class. Recreational activities were divided into eight types: sports, culture, music, creative activities, gardening, radio and TV, sightseeing, and investment/gambling. The Cox proportional-hazards regression model was used to determine an age-adjusted hazard ratio (HR) for each in both males and females. Subsequently, those factors with a significant HR were used as predictive variables in stepwise regression for further clarification. At the end of the 3-year study, the number of subjects who received Certification associated with dementia was 330 (139 males, 191 females); 9,390 were otherwise categorized. The percentage of Certified subjects was 1.13 per year. The following predictive factors showed significant HRs: in both the male and female groups, self-awareness of forgetfulness (male 1.69, female 2.59) and 4 points or less in instrumental independence scores (male 1.80, female 2.23); in the males, living alone (2

  14. Computerized tomography findings in Fahr's syndrome Achados da tomografia computadorizada na síndrome de Fahr

    Directory of Open Access Journals (Sweden)

    Andréia V. Faria

    2004-09-01

    Full Text Available We analyzed computerized tomography (CT findings in six patients with Fahr's syndrome. They presented calcifications in basal ganglia, dentate nucleus, subcortical region and semioval center, due to alteration in calcium metabolism or due to senile relative hypoxemic state. The image pattern was not strictly related with etiology, although some differences in dystrophic senile calcifications (the only one present in semioval center and absent in subcortical region. CT is an easy exam, has maximum sensitivity and allows diagnosis, contributing to early treatment of many etiologies of Fahr's syndrome.Analisamos os achados de tomografia computadorizada (TC de seis pacientes com síndrome de Fahr. Eles apresentaram calcificações nos gânglios da base, núcleo denteado, região subcortical e centro semi-oval, devidas a distúrbios no metabolismo do cálcio ou a estado de hipóxia relativa, por senilidade. O padrão de imagem não apresenta relação clara com a etiologia, apesar de algumas diferenças no caso das calcificações distróficas senis (as únicas presentes nos centros semi-ovais e ausentes na região subcortical. TC é um exame de fácil realização, máxima sensibilidade e permite o diagnóstico, contribuindo para o tratamento precoce de muitas das etiologias da síndrome de Fahr.

  15. Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome).

    Science.gov (United States)

    Hyman, B T; West, H L; Rebeck, G W; Buldyrev, S V; Mantegna, R N; Ukleja, M; Havlin, S; Stanley, H E

    1995-04-11

    The discovery that the epsilon 4 allele of the apolipoprotein E (apoE) gene is a putative risk factor for Alzheimer disease (AD) in the general population has highlighted the role of genetic influences in this extremely common and disabling illness. It has long been recognized that another genetic abnormality, trisomy 21 (Down syndrome), is associated with early and severe development of AD neuropathological lesions. It remains a challenge, however, to understand how these facts relate to the pathological changes in the brains of AD patients. We used computerized image analysis to examine the size distribution of one of the characteristic neuropathological lesions in AD, deposits of A beta peptide in senile plaques (SPs). Surprisingly, we find that a log-normal distribution fits the SP size distribution quite well, motivating a porous model of SP morphogenesis. We then analyzed SP size distribution curves in genotypically defined subgroups of AD patients. The data demonstrate that both apoE epsilon 4/AD and trisomy 21/AD lead to increased amyloid deposition, but by apparently different mechanisms. The size distribution curve is shifted toward larger plaques in trisomy 21/AD, probably reflecting increased A beta production. In apoE epsilon 4/AD, the size distribution is unchanged but the number of SP is increased compared to apoE epsilon 3, suggesting increased probability of SP initiation. These results demonstrate that subgroups of AD patients defined on the basis of molecular characteristics have quantitatively different neuropathological phenotypes.

  16. Studies of cerebral blood flow and metabolism in patients with senile dementia of the Alzheimer's type and diagnostic evaluation of the dementing illnesses by positron emission tomography

    Energy Technology Data Exchange (ETDEWEB)

    Sakamoto, Shizuki (Nippon Medical School, Tokyo (Japan))

    1990-06-01

    This study was designed to determine cerebral dysfunction in senile dementia of the Alzheimer's type (SDAT). Regional cerebral blood flow (rCBF), oxygen extraction fraction and cerebral oxygen consumption (rCMRO{sub 2}) were studied in SDAT patients (n=16) and age-matched normal elderly people (n=5) by positron emission tomography (PET) using the O-15 labeled CO{sub 2} and O{sub 2} inhalation technique. The SDAT group had a significantly lower values in both rCBF and rCMRO{sub 2} than the normal control. During the early stage of SDAT, rCMRO{sub 2} was restricted to the temporal cortex; and it extended to the parietal and frontal cortices associated with a decreased rCBF as the disease progressed. Posterior temporal and posterior parietal association cortices were considered to be the most damageable part during the early stage. Bilateral differences in oxygen metabolism of the temporal and parietal cortices tended to be in accordance with clinical symptoms for disturbed speech and visuospatial function, suggesting the correlation between rCMRO{sub 2} and rCBF in SDAT. Findings of PET in SDAT differed from those obtained in each patient with multi-infarct dementia or Pick disease, in that both rCBF and rCMRO{sub 2} were inhomogeneously decreased over the whole cerebral cortex for multi-infarct dementia and in that homogeneously decreased rCBF and rCMRO{sub 2} were restricted to the frontal and temporal cortices for Pick disease. PET may have a potential for differentiating various types of dementia. (N.K.).

  17. Correction of senile entropion using holmium laser

    Science.gov (United States)

    Kecik, Mariusz; Kecik, Dariusz; Kasprzak, Jan; Brodecka, Malgorzata

    2003-10-01

    Ninety-eight patients were included in clinical trials. They were divided into 3 groups, depending on the severity of lower lid inversion. Eighteen patients were included in the group with mild lid inversion; 59 patients had moderate lid inversion and in 21 patients the inversion was severe. Additionally, the patients were subdivided into two groups, according to their age - up to and above the age of 69 years. In both age groups, patients with moderate entropion predominated. All patients underwent photocoagulation of the lower lid. Post-operative wound healing took about 14 days. The effect was described as good when the position of the lid returned to normal with the lashes at an angle of about 45° to the free edge of the eyelid. When the position of the eyelid was normal with the lashes at an angle of about 60° or more to the edge of the lid and not rubbing against the globe, the effect was considered satisfactory. When the inversion of the lid was not corrected, the effect was unsatisfactory. Good effects were seen in 61% of patients, 21% of the patients demonstrated satisfactory effects and in 18% the outcome was unsatisfactory. The best results were observed in patients with mild entropion, aged 69 years and younger.

  18. Prevalence of behavioral changes in senile dogs

    Directory of Open Access Journals (Sweden)

    Denis Jeronimo Svicero

    Full Text Available ABSTRACT: Owing to improvements in animal welfare, such as in nutrition, preventive medicine, and diagnostic tools, older dogs have become increasingly more prevalent than before. Unfortunately, there is an increasing number of dogs presenting behavioral changes correlated with this growth in the geriatric population. However, many of these owners consider these signs as normal for old age. This study aimed to determine the prevalence of clinical signs related with behavioral changes in the canine geriatric population admitted to the Veterinary Hospital of the Veterinary Medicine and Animal Science College of Universidade Estadual Paulista. The owners of 800 old dogs completed a questionnaire about disorientation, changes in social interaction, loss of training (house soiling, changes in the wake-sleep cycle, physical activity, memory, learning, consciousness, and perception. The results showed that the prevalence of behavioral changes in the canine geriatric population was 90.7% of dogs that presented at least one of these behavioral changes, and 22.3% with at least six changes, and with changes in physical activity (58.5% and loss of acquired training (30.2% being the highest percentage groups that were reported by the owners. We concluded that the prevalence of behavioral changes related with aging in the canine geriatric population was high, and that it was important to include questions about behavioral changes during regular veterinary clinical appointments to identify these clinical signs earlier and investigate the possible causes of the cognitive impairment, including neurological diseases, such as Canine Cognitive Dysfunction Syndrome.

  19. A serendipidade na medicina e na anestesiologia

    OpenAIRE

    Vale, Nilton Bezerra do; Delfino, José; Vale, Lúcio Flávio Bezerra do

    2005-01-01

    JUSTIFICATIVA E OBJETIVOS: Neste trabalho foram examinados mais de uma centena dos mais felizes acoplamentos de uma mente brilhante com a sorte benfazeja (serendipidade), através da releitura das mais relevantes histórias sobre invenções e descobertas relacionadas à ciência (n = 46), à Medicina (n = 46) e à Anestesiologia (n = 16). CONTEÚDO: Conceito de serendipidade; exemplos célebres de serendipidade em Ciência e Tecnologia; serendipidade na pesquisa e prática médicas; serendipidade na Anes...

  20. NA60 Status Report

    CERN Document Server

    Usai, G

    2010-01-01

    This report shortly summarizes the main results obtained from the analysis of the NA60 data during 2010, perspectives for the analysis activity during 2011 and the requests to CERN following from them. In addition, renewed interest is expressed for a possible continuation of NA60, including future running at lower SPS energies.

  1. At NA2

    CERN Multimedia

    1977-01-01

    One of the NA2 calorimeter sections is moved in. The NA2 calorimeter was divided in two halves, to the left and the right of the beam, each half consisting of sheets of passive high Z material interleaved with blades of plastic scintillators. The photo shows on the right, the upstream 'electron' module with eleven lead plates for a total radiation length of 20.

  2. Polarization dependence of Na* + Na* associative ionization revisited

    NARCIS (Netherlands)

    Meijer, H.A.J.; Meulen, H.P. v.d.; Morgenstern, R.; Hertel, I.V.; Meyer, E.; Witte, R.

    1986-01-01

    The dependence of the associative ionization process Na 3 2P3/2 + Na 3 2P3/2 → Na2+ + e- on the polarization of the laser light used for Na excitation was independently investigated in Utrecht and Berlin. The purpose of this paper is to clarify discrepancies between two other earlier experimental

  3. Letramento na contemporaneidade

    OpenAIRE

    Kleiman, Angela B.

    2014-01-01

    Neste trabalho examino a relação entre letramento e contemporaneidade, tomando como base para a discussão o letramento no mundo escolar e sua relação com os letramentos de outras instituições do mundo contemporâneo, a fim de determinar as relações entre as finalidades contemporâneas da leitura e da escrita (em outras palavras, o que significa ser letrado na contemporaneidade) e as práticas mobilizadas e as atividades realizadas na escola para atingir essas finalidades. Através de diversos exe...

  4. Nietzsche na moda

    OpenAIRE

    José,João

    2016-01-01

    Resumo Ao resgatar o filósofo alemão do esquecimento, Stefan Zweig seria o principal responsável pela atual "voga Nietzsche". A edição brasileira de seu livro em 1931 e o artigo "L'actualité de Nietzsche", publicado anonimamente na França em 1933, atestariam o crescente interesse pelo autor de Zaratustra . A presença de Nietzsche na cena contemporânea, todavia, dever-se-ia não somente aos ensaios de outros estudiosos como Salomé (1893), Bertram (1918), Andler (1920) e Walz (1932), mas a um fe...

  5. Riso na epilepsia

    Directory of Open Access Journals (Sweden)

    Edymar Jardim

    1967-06-01

    Full Text Available São estudados três casos de síndrome convulsiva temporal, com manifestações concomitantes de riso na sua fase inicial. As características principais foram a imotivação e á incoercibilidade do riso. Esses sintomas desapareceram com o uso de anticonvulsivantes.

  6. Biotecnologia na agricultura

    Directory of Open Access Journals (Sweden)

    Helaine Carrer

    2010-01-01

    Full Text Available A expectativa de o crescimento populacional atingir 9 bilhões de habitantes em 2050 em adição às questões da sustentabilidade e do aquecimento global nos desafiam a aumentar a oferta de alimentos. Uma metodologia alternativa que contribua para a redução do impacto desse cenário envolve a biotecnologia, que, nas últimas décadas, trouxe marcantes oportunidades tecnológicas na agricultura, resultando em relevante desenvolvimento na obtenção de novas variedades de plantas, na melhoria da qualidade de diversos alimentos e atualmente também na bioenergia. As técnicas biotecnológicas envolvendo os marcadores moleculares, a genômica e a transformação genética estão transformando a agricultura e são discutidas neste artigo.The expected population growth to reach 9 billion by 2050 in addition to issues of sustainability and global warming challenges us to increase the supply of food. An alternative approach to help reducing the impact of this scenario involves biotechnology which in recent decades has brought remarkable technological opportunities in the agriculture that resulted in relevant development in obtaining new plant varieties, improved quality of different foods, and now also in bioenergy. The biotechnology techniques involving molecular markers, genomics and genetic transformation are transforming agriculture and will be discussed in this article.

  7. Hidroma subdural na fossa posterior

    Directory of Open Access Journals (Sweden)

    José Carlos Vasques

    1970-03-01

    Full Text Available Os autores relatam um caso de hidroma subdural na fossa craniana posterior conseqüente a traumatismo na região occipital. O paciente foi operado com pleno sucesso. A raridade da localização de hidroma na fossa posterior é salientada, sendo discutidos os possíveis mecanismos etio-patogênicos.

  8. A epilepsia na neurocisticercose

    Directory of Open Access Journals (Sweden)

    Luís Marques-Assis

    1972-12-01

    Full Text Available Foram estudados 131 casos de epilepsia com etiologia cisticercótica comprovada. A idade variou de 2 a 68 anos; 75 pacientes eram de sexo masculino e 56 de sexo feminino; 117 eram brancos, 10 pardos, três pretos e um amarelo. A idade de início da doença predominou na primeira década. O estudo foi feito em relação ao tipo de epilepsia, ao tempo decorrido após a primeira crise, à freqüência das crises e ao eletrencefalograma relativamente às epilepsias em geral. Investigação foi feita também em relação à cefaléia, aos achados neurológicos, liquóricos, radiológicos simples e contrastados e anátomo-patológicos. A análise dos resultados permitiu aos autores as seguintes conclusões: 1 No grupo de neurocisticercose o início da doença predominou na primeira e a partir da quarta década em relação às epilepsias em geral. 2 Dentre as manifestações clínicas predominaram as formas convulsivas da doença (61%, sendo as crises bravas-jacksonianas as menos freqüentes (4%; quando comparadas com as epilepsias em geral, verifica-se incidência menor das convulsões generalizadas na neurocisticercose. 3 Quanto ao tempo de doença, verifica-se predomínio das formas de duração mais curta (um ano ou menos na neurocisticercose. 4 A severidade da epilepsia, traduzida pela freqüência das crises, foi menor no grupo com neurocisticercose. 5 Excluídos os casos com anormalidades eletrencefalográficas contínuas, foram encontrados maiores índices percentuais de EEG normal na neurocisticercose que nas epilepsias em geral. 6 A cefaléia estava presente em 68% dos casos, assumindo caráter paroxístico na maior parte (78%; em 67% dos casos com cefaléia paroxística não havia concomitantemente sinais de hipertensão intracraniana; nos casos com cefaléia contínua, em apenas dois (13% esses sinais não estavam presentes. 7 Na maior parte dos casos (62% as manifestações epilépticas se apresentaram isoladamente, sem sinais neurol

  9. Prevalência de transtornos oculares na população de idosos residentes na cidade de Veranópolis, RS, Brasil Prevalence of ocular diseases in a population of elderly residents of the city of Veranópolis, Brazil

    Directory of Open Access Journals (Sweden)

    Flávio Antônio Romani

    2005-10-01

    Full Text Available OBJETIVO: Avaliar os transtornos oculares e a sua prevalência em pessoas com 80 anos de idade, ou mais, na cidade de Veranópolis, Rio Grande do Sul, Brasil. MÉTODOS: 187 idosos foram submetidos a exame oftalmológico por meio de inspeção externa, motilidade extrínseca, medidas de acuidade visual para longe e perto, tonometria de aplanação, biomicroscopia, cicloplegia, fundoscopia direta e esquiascopia estática. RESULTADOS: As doenças mais prevalentes foram: presbiopia em 173 (92,5% pacientes, catarata em 160 (85,6%, ectrópio senil em 130 (69,5%, hipermetropia em 130 (69,5% e a degeneração macular relacionada à idade (DMRI em 59 (31,5%. Na população estudada, 85 (45,4% pacientes apresentaram baixa visual acentuada cujas causas principais eram a catarata em 46 (54,1% e erros de refração em 16 (18,9% dos idosos. A principal causa de queixas dos idosos foi relacionada com a presença de ectrópio senil. CONCLUSÃO: Doenças comuns como a catarata e os erros de refração continuam a ser um desafio para os oftalmologistas, pois são importantes causas de dificuldade visual nos idosos, com conseqüente perda de qualidade em suas vidas.ABSTRACT PURPOSE: To evaluate the prevalence of diseases of the eye in a population aged 80 years and above in the city of Veranopolis, Rio Grande do Sul, Brazil. METHODS: 187 elderly people were submitted to ophthalmologic tests including external inspection, ocular motility examination, visual acuity determination for near and far distance, applanation tonometry, biomicroscopy, cyclopegia, direct fundus examination and static skiascopy. RESULTS: The most prevalent disease was presbyopia in 173 (92,5% patients, cataract in 160 (85,6%, age-related ectropion in 130 (69,5%, hypermetropia in 130 (69,5% and age-related macular degeneration (ARMD in 59 (31,5% patients. 85 (45,4% patients presented marked low vision whose main causes were cataract in 46 (54,1% and refractive error in 16 (18,9% of the studied

  10. The CERES / NA45 experiment

    CERN Multimedia

    Laurent Guiraud

    2000-01-01

    Ceres is one of the second generation heavy ion experiments at CERN's SPS. It is dedicated to the study of electron-positron pairs in relativistic nuclear collisions. NA45 is one of the seven experiments (NA44, NA45, NA49, NA50, NA52, WA97/NA57 and WA98) involved in CERN's Heavy Ion programme which provided evidence for the existence of a new state of matter, the quark-gluon plasma. In this state, quarks, instead of being bound up into more complex particles such as protons and neutrons, are liberated and roam freely. Theory predicts that this state must have existed at about 10 microseconds after the Big Bang, before the formation of matter as we know it today.

  11. na Perua

    Directory of Open Access Journals (Sweden)

    Jorge Carvalho

    1989-01-01

    Full Text Available Antes de se caracterizar como tentativa de ensaio ou de análise a qualquer coisa, o presente artigo tem, antes de mais nada, a pretensão de se constituir uma provocação ao debate acerca da questão do esporte na escola. A provocação parte basicamente do relato da minha experiência pessoal como Secretário da Educação do Município de Aracaju, cargo que exerci no período de 1º de janeiro de 1986 a 27 de janeiro de 1987.

  12. Envolvimento pulmonar na polimiosite

    Directory of Open Access Journals (Sweden)

    Direndra Hasmucrai

    2010-07-01

    Full Text Available Resumo: Introdução: A polimiosite (PM e a dermatomiosite são classificadas como miopatias inflamatórias idiopáticas. O envolvimento pulmonar por PM é pouco frequente, estando descrito na literatura em cerca de 10% de casos.Os autores apresentam um caso de uma mulher de 75 anos, com queixas de febre, perda ponderal, artralgias, mialgias e diminuição simétrica e proximal da força muscular com impotência funcional dos membros superiores e inferiores, com início um mês antes do internamento. Apresentava infiltrados pulmonares na telerradiografia de tórax. Após estudo exaustivo estabeleceu-se o diagnóstico de envolvimento pulmonar na forma de pneumonia organizativa por PM. Efectuou-se corticoterapia e terapêutica com micofenolato com melhoria clínica, analítica e radiológica.Conclusão: Neste caso, foi a alteração na telerradiografia de tórax numa doente sem sintomatologia respiratória que levou ao estudo exaustivo até ao diagnóstico de PM, realçando mais uma vez a importância da telerradiografia no rastreio de patologias de outros foros.Rev Port Pneumol 2010; XVI (4: 671-677 Abstract: Introduction: Polymyositis and dermatomyositis are classified as idiopathic inflammatory myopathies. Interstitial lung disease is rare and is described in the literature in about 10% of cases.The authors describes a case of 75 year old woman presenting with one month evolution of fever, weight loss, arthralgia, myalgia and symmetric and proximal muscle weakness of upper and lower limbs. Nonspecific interstitial changes was found in chest X-ray. After exhaustive study, the diagnosis of pulmonary envolvement in the form of organizing pneumonia by polymyositis, was established. Glucocorticoids and mycophenolate were prescribed with good clinical, analytical and radiological outcome.Conclusion: In this case, it was the changes in the chest X-ray in a patient without respiratory sym ptomatology, that conducted to exhaustive study to polymyositis

  13. Envolvimento pulmonar na polimiosite

    Directory of Open Access Journals (Sweden)

    Direndra Hasmucrai

    2010-07-01

    Full Text Available Resumo: Introdução: A polimiosite (PM e a dermatomiosite são classificadas como miopatias inflamatórias idiopáticas. O envolvimento pulmonar por PM é pouco frequente, estando descrito na literatura em cerca de 10% de casos.Os autores apresentam um caso de uma mulher de 75 anos, com queixas de febre, perda ponderal, artralgias, mialgias e diminuição simétrica e proximal da força muscular com impotência funcional dos membros superiores e inferiores, com início um mês antes do internamento. Apresentava infiltrados pulmonares na telerradiografia de tórax. Após estudo exaustivo estabeleceu-se o diagnóstico de envolvimento pulmonar na forma de pneumonia organizativa por PM. Efectuou-se corticoterapia e terapêutica com micofenolato com melhoria clínica, analítica e radiológica. Conclusão: Neste caso, foi a alteração na telerradiografia de tórax numa doente sem sintomatologia respiratória que levou ao estudo exaustivo até ao diagnóstico de PM, realçando mais uma vez a importância da telerradiografia no rastreio de patologias de outros foros. Abstract: Introduction: Polymyositis and dermatomyositis are classified as idiopathic inflammatory myopathies. Interstitial lung disease is rare and is described in the literature in about 10% of cases.The authors describes a case of 75 year old woman presenting with one month evolution of fever, weight loss, arthralgia, myalgia and symmetric and proximal muscle weakness of upper and lower limbs. Nonspecific interstitial changes was found in chest X-ray. After exhaustive study, the diagnosis of pulmonary envolvement in the form of organizing pneumonia by polymyositis, was established. Glucocorticoids and mycophenolate were prescribed with good clinical, analytical and radiological outcome. Conclusion: In this case, it was the changes in the chest X-ray in a patient without respiratory symptomatology, that conducted to exhaustive study to polymyositis diagnosis, enhancing once again the

  14. Comprometimento pulmonar na leptospirose

    Directory of Open Access Journals (Sweden)

    Jorge Eduardo Manhães de Carvalho

    1992-03-01

    Full Text Available Em 23 pacientes com leptospirose apresentando comprometimento pulmonar, internados no Hospital Universitário Antônio Pedro da XJFF, Niterói, hemoptise e hemoptóicos foram observados em 21,7% e 30,4%, respectivajnente. Gasometria arterial revelou hipoxemia e hipocapnia na maioria dos casos. Radiografia de tórax em 15 pacientes mostrou comprometimento alveolar em 60%, comprometimento intersticial-reticular em 6%, padrão misto (alveolar e intersticial em20%e ausência de alterações radiológicas em 14%. A necrópsiade 13 pacientes mostrou edema, congestão e hemorragia nos pulmões em 100% dos casos. A hemorragia foi focal em 46% e difusa em 54% dos casos. Houve formação de membrana hialina em 30% e trombos de fibrina em 46% dos pulmões estudados, o que estabelece o diagnóstico da coagulação intravascular disseminada e a ocorrência da síndrome de angústia respiratória na leptospirose.

  15. ANALIZA POSLOVNE KULTURE NA JAPONSKEM

    OpenAIRE

    Ocvirk, Katja

    2012-01-01

    Poslovanje na mednarodnih trgih se z globalizacijo vedno bolj spreminja. V delu diplomskega seminarja sem opredelila kulturo in opisala njene pomembne sestavine ter značilnosti. Spoznala sem, da mora biti poslovnež, ki deluje na mednarodnem trgu, zelo dobro pripravljen in seznanjen s kulturnimi razlikami, da se izogne nepotrebnim napakam in spodrsljajem. Menim, da moramo pri poslovanju s poslovnimi partnerji, ki prihajajo iz drugih kultur, vedeti, kako deluje njihovo poslovno okolje. Na ...

  16. NA48 prototype calorimeter

    CERN Multimedia

    1990-01-01

    This is a calorimeter, a detector which measures the energy of particles. When in use, it is filled with liquid krypton at -152°C. Electrons and photons passing through interact with the krypton, creating a shower of charged particles which are collected on the copper ribbons. The ribbons are aligned to an accuracy of a tenth of a millimetre. The folding at each end allows them to be kept absolutely flat. Each shower of particles also creates a signal in scintillating material embedded in the support disks. These flashes of light are transmitted to electronics by the optical fibres along the side of the detector. They give the time at which the interaction occurred. The photo shows the calorimeter at NA48, a CERN experiment which is trying to understand the lack of anti-matter in the Universe today.

  17. Na Cauda do Cometa

    Science.gov (United States)

    Voelzke, M. R.

    2009-01-01

    Quando viam um cometa, os antigos gregos imaginavam uma estrela com uma vasta cabeleira. Não à toa, a palavra deriva do termo koma, que significa cabelo. Constituídos por fragmentos de gelo e gases, os cometas possuem um núcleo sólido, que pode ter vários quilômetros de diâmetro, e uma cauda que sempre aponta na direção contrária ao Sol, devido aos ventos solares. Graças à aparência de pontos luminosos em movimento (ao contrário de outros astros, que parecem estáticos), esses corpos celestes foram interpretados por diferentes povos com muito misticismo, inspirando mitos tanto de boas-novas como de maus presságios. Conheça algumas dessas histórias:

  18. A ENGENHARIA NA ESCOLA

    Directory of Open Access Journals (Sweden)

    Valéria Pelizzer Casara

    2015-04-01

    Full Text Available Este projeto teve por objetivo principal mostrar às jovens do ensino médio, como as áreas de exatas e de engenharia podem estar inseridas em situações rotineiras por elas vivenciadas e incentivá-las para ingressarem nessas áreas. O projeto foi executado na escola de ensino Médio Nelson Horostecki na cidade de Chapecó, Santa Catarina. Mostrou-se de forma simples que as áreas de exatas e de engenharia têm aplicações práticas nas nossas vidas. No desenvolvimento do projeto, realizaram-se oficinas na escola cujo tema principal abordado foi o processo de fabricação do chocolate, visto que o mesmo é um produto muito apreciado pelas adolescentes. Dentro dessa temática, foram trabalhadas as questões que envolvem conhecimentos das áreas de exatas e de engenharia, mais especificamente a Engenharia Ambiental. O projeto auxiliou na formação cidadã e também na escolha profissional das meninas. Muitas das alunas participantes nunca haviam tido contato direto com alunos graduandos de cursos na área das exatas. Mais ainda, este projeto oportunizou a aproximação da universidade com a comunidade externa. Palavras-chave: Extensão Universitária, Ciências Exatas e Engenharia, Chocolate, Oficinas.   Engineering in the school Abstract: The main objective of this project was to show high school female students how the exact sciences and engineering can be included in their routine situations encouraging them to entering in these areas. The project was carried out at the Nelson Horostecki High School in Chapecó, Santa Catarina State, Brazil. It was showed in a simple manner how exact sciences and engineering have practical applications in our lives. Workshops were conducted in the school during the execution of the project in which the main subject was the chocolate manufacturing process, since chocolate is a product greatly appreciated by the young female people. Within this matter, the activities were performed using the knowledge of

  19. Hodler à Iéna

    OpenAIRE

    2017-01-01

    A la mort de Hodler, on demanda que les planches qui recouvrait la fresque de Iéna, depuis la protestation contre le bombardement de Reims, soit enlevées. Les autorités de Iéna ont refusé énergiquement.

  20. Valores na escola

    Directory of Open Access Journals (Sweden)

    Menin Maria Suzana De Stefano

    2002-01-01

    Full Text Available Neste texto pretende-se discorrer sobre valores morais na escola e suas implicações para a formação de professores. Para tanto discutir-se-á, em primeiro lugar, e brevemente, o que são valores morais, ou éticos, e como a escola pode situar-se em relação a eles. Em seguida, serão relatadas algumas observações a respeito de valores de professores e práticas daí decorrentes. São comentados resultados de pesquisa que ilustram a transmissão de valores de forma doutrinal e a educação moral e cívica tal como realizada na ditadura militar, e, por outro lado, a posição relativista e/ou de laissez-faire que certas escolas podem adotar, metodologicamente, sobre a educação em valores. Finalmente, defender-se-á a idéia de que é necessária uma discussão sobre valores pelos diversos membros da escola e uma opção por uma metodologia para ensiná-los, seja os professores, em sua formação inicial e continuada, seja os alunos. A teoria de desenvolvimento moral de Jean Piaget será apresentada como uma referência possível para a educação em valores. Exemplos de situações escolares de conflito de valores entre direção, pais e alunos são discutidas para ilustrar como uma escola pode adotar um procedimento democrático de educação em valores, que se apresenta como um terceiro caminho possível de educação moral nas escolas, além das posições doutrinárias ou relativistas.

  1. A aposta na filosofia

    Directory of Open Access Journals (Sweden)

    Márcio Suzuki

    2011-12-01

    Full Text Available Para Hume, filosofar é uma atividade semelhante às demais ocupações humanas. A decisão que leva à atividade filosófica é menos resultado de uma argumentação teórica do que fruto de um cálculo prático, que é entendido como uma caça ou um jogo. O objetivo deste trabalho será o de mostrar que no jogo filosófico perde quem joga sério demais. A aposta na filosofia tem que passar pelo bom humor e pela diversão: uma resposta a Pascal?For Hume, philosophy is in itself neither more nor less important than other human activities. On the contrary, it can be explained from its resemblance with game and hunting. If one chooses to dedicate himself to philosophy, his decision is not the consequence of logical reasoning, but depends on practical evaluation, which has something to do with gambling. The following text tries to show that in philosophy, like in other games, the loser will be the one who plays too earnestly. The philosophical game requires good humour and some relaxation: Is this a good answer to Pascal's pari?

  2. A Arquitetura na Cidade

    Directory of Open Access Journals (Sweden)

    Euler Sandeville Junior

    2013-07-01

    Full Text Available Este artigo é uma reflexão sobre três casos em que a arquitetura define a configuração do espaço público, investigando seus significados e pressupostos. São levantadas questões que não comportam respostas definitivas, mas que induzem a alguns parâmetros para discutir a atuação do arquiteto no espaço público, nas áreas centrais de nossas cidades. Nosso título é, sem dúvida, devedor do célebre trabalho de Aldo Rossi, a Arquitetura da cidade (1966. Porém, nos ocupamos apenas da inserção da arquitetura na cidade e numa perspectiva teórica muito distinta, reconhecendo para o projeto do objeto arquitetônico uma dependência do espaço e do tempo e das relações sociais que assim se estabelecem. São analisados o Memorial da América Latina, a estação Barra Funda do Metrô e a Praça da Sé. São aqui entendidos como campos de projeto da paisagem e, como tal, problematizados.

  3. O SUBLIME NA MODERNIDADE

    Directory of Open Access Journals (Sweden)

    Martha de Almeida

    2009-03-01

    Full Text Available A obra Uma investigação filosófica sobre a origem de nossas idéias do sublime e dobelo, do sensualista inglês Edmund Burke (1757, data as origens do sublime na Modernidade. Nosublime ocorre é um prazer ligado à dor, um "horror delicioso" que sentimos quando acreditamosque estamos em perigo sem que isso esteja ocorrendo realmente. Em O mundo como Vontade erepresentação Schopenhauer assume as influências que sofreu de Kant no que diz respeito à suainterpretação sobre o belo e o sublime, porém difere dele quanto à natureza dessa impressão. ParaSchopenhauer a experiência estética pressupõe a dissolução da subjetividade num movimento decontemplação das idéias livre do querer imposto pela vontade individual. As idéias deSchopenhauer influenciaram a estética do Nietzsche de O nascimento da tragédia.

  4. SPOLNO NADLEGOVANJE NA DELOVNEM MESTU

    OpenAIRE

    Rubič, Gašper

    2016-01-01

    V diplomskem delu smo v uvodu predstavili problem spolnega nadlegovanja na delovnem mestu in predstavili podjetje TEKSTIL d.d. V nadaljevanju smo z anketo raziskali, ali problem spolnega nadlegovanja na delovnem mestu v obravnavanem podjetju obstaja in če, kako se nanj odziva okolje. V teoretičnem delu smo nadaljevali in predstavili definicijo spolnega nadlegovanja, ki je kakršna koli oblika nezaželenega verbalnega in neverbalnega ali fizičnega ravnanja spolne narave z učinkom ali nameno...

  5. Hemisferectomia na hemiplegia infantil

    Directory of Open Access Journals (Sweden)

    Rolando A. Tenuto

    1956-03-01

    Full Text Available Os autores relatam o caso de um paciente com 18 anos de idade, portador de paralisia cerebral instalada aos 4 anos de idade após moléstia febril prolongada (hemiplegia esquerda, crises convulsivas generalizadas, freqüentes e rebeldes à medicação, deficiência mental e alterações de conduta. O eletrencefalograma e o pneumencefalograma revelaram alterações graves do hemisfério direito; tendo o primeiro destes exames demonstrado a existência de perturbações propagadas ao outro hemisfério. Foi praticada a hemisferectomia direita. Durante o ato cirúrgico, por exigência técnica foram extirpados, além do hemisfério cerebral, os dois terços rostrais do núcleo caudado e o núcleo amigdalóide. No pós-operatório foi intercorrência de osteomielite e meningite, medicadas com antibióticos e seqüestrectomia. Apesar da complicação pós-operatória, instalou-se progressiva melhora em relação à conduta social; diminuiu também a espasticidade no membro inferior esquerdo e não mais se repetiram as crises convulsivas. Não foram observadas modificações quanto ao rendimento intelectual e quanto aos distúrbios sensitivos que existiam antes da intervenção cirúrgica. O exame neurocular mostrou hemianopsia homônima esquerda. Êstes resultados são concordantes com os assinalados na literatura sobre o assunto.

  6. Active transport of Na+ by reconstituted Na,K-ATPase

    International Nuclear Information System (INIS)

    Boldyrev, A.A.; Svinukhova, I.A.

    1987-01-01

    The ability of ATP, CTP, ITP, GTP, and UTP to support ouabain-sensitive accumulation of Na + by proteoliposomes with a reconstituted Na/K-pump was investigated. At a low [Na + ]/[K + ] ratio in the medium (20 mM/50 mM), a correlation is observed between the proton-accepting capacity of the nucleotide and its effectiveness as a substrate of active transport. To test the hypothesis of the importance of the presence of a negative charge in the 1-position of the purine (3-pyrimidine) base of the nucleotide for mutual transitions between the Na- and K-conformations of Na,K-ATPase they used two analogs of ATP: N 1 -hydroxy-ATP, possessing proton acceptor capacity, and N 1 -methoxy-ATP, in the molecule of which the negative charge is quenched by a methyl group. The first substrate supports active accumulation of Na + in proteoliposomes at the same rate as ATP, whereas the second substrate is relatively ineffective

  7. Risbjerg: Historisk stemmeskred med NA

    DEFF Research Database (Denmark)

    Thomsen, Søren Risbjerg

    2007-01-01

    ANALYSE: NA flytter 12,3 pct. af stemmerne i majs meningsmålinger - historisk mange vælgere på en måned, skriver professor Risbjerg. Udgivelsesdato: 3. juni 2007......ANALYSE: NA flytter 12,3 pct. af stemmerne i majs meningsmålinger - historisk mange vælgere på en måned, skriver professor Risbjerg. Udgivelsesdato: 3. juni 2007...

  8. Na via do Behemoth

    Directory of Open Access Journals (Sweden)

    Gérard Rabinovitch

    2008-06-01

    Full Text Available O momento nazista permanece um enigma impensado de que a cultura contemporânea continua cativa. O autor levanta a hipótese de que a persistência desse enigma e seus estragos duráveis se devem à insistência dos pensamentos político, sociológico e filosófico em construírem o nazismo à luz da metáfora hobbesiana do Leviatã. Propõe retomar a questão do nazismo sob a perspectiva do Behemoth, antônimo do Leviatã. Para tanto, sugere a necessidade de retornar a Freud e à psicanálise, balizas de um possível novo pensamento do político que escrutine a destrutividade nazista. Propõe ainda sondar as homologias entre nazismo, corjas e máfias, com base na figura da " heroicização da violência" que lhes seria comum. E avança um modelo " econômico" : a quimera, suscetível de capturar o caráter heterotópico e heterocrônico de sua construção criminosa.The paths of Behemoth. The Nazi moment remains as the thoughtless enigma of which contemporary culture is still captive. The author raises the hypothesis where the persistency of this enigma and its durable damages are due to the insistence of the political, social and philosophical thoughts in building the Nazism at the view of the Hobbesian metaphor of Leviathan. It is here proposed to resume the Nazism matter under Behemoth's perspective, antonym to Leviathan. For such, it is suggested a necessity to look back at Freud and the psychoanalysis, structured by a possible new political thought which scrutinizes the destructivity of the Nazism. It is also here proposed to gaze at the homologies between Nazism, mafias and gangs, with a base in the figure of " violence as a heroically act" that are their common ground. The author also advances an economical model: the chimera susceptible to capture the heterotopic and heterochronic character of its criminal construction.

  9. Estresse ocupacional na enfermagem atuante na unidade de terapia intensiva

    OpenAIRE

    Borges Teixeira, Larissa; Portela Veloso, Lorena Uchôa; Universidade Estadual do Piauí; Pereira Ribeiro, Ítalo Arão; Universidade Estadual do Piauí; Nunes de Oliveira, Tauane; Instituto de Ensino Superior Franciscano; Leal Cortez, Antônio Carlos; Universidade Estadual do Piauí

    2017-01-01

    Introdução: O estresse tem sido um dos problemas que mais tem acometido a equipe de enfermagem dentro da unidade de terapia intensiva (UTI), causando prejuízo funcional, bem como instabilidade na saúde desses profissionais. Objetivo: Descrever, através da revisão integrativa, o estresse no trabalho da enfermagem na UTI, bem como identificar fatores, sinais e sintomas associados ao estresse ocupacional. Método: Trata-se de uma pesquisa integrativa, utilizando como banco de dados a Biblioteca V...

  10. Corpo e sexualidade na gravidez

    Directory of Open Access Journals (Sweden)

    Natalúcia Matos Araújo

    2012-06-01

    Full Text Available Estudo etnográfico que teve como objetivo compreender como as gestantes vivenciam os processos fisiológicos do seu corpo durante a gestação e a sua repercussão na sexualidade. A pesquisa envolveu sete mulheres residentes em bairro popular de São Paulo. Na coleta de dados, utilizou-se observação participante e entrevista com questões norteadoras. Os dados foram apresentados na forma de narrativa e posteriormente organizados nas categorias: Percebendo as transformações corporais; Convivendo com as mudanças no corpo; Sentimentos e sensações na vida sexual durante a gestação e imaginando o corpo e a sexualidade após a gestação. As mulheres referiram-se às transformações do corpo como desconfortos e expressaram a preocupação de que fossem definitivas. Expressaram o desejo de que, após o parto, o corpo volte a ser como era e que volte a sentir desejo sexual. O reconhecimento destes fatos constitui-se numa ferramenta primordial na adequação das práticas profissionais.

  11. All new for NA62

    CERN Multimedia

    Antonella Del Rosso

    2012-01-01

    This week sees the start of the first run of the new NA62 experiment. This will be a unique opportunity for the collaboration to test its new beam, new detectors and new data acquisition system before the physics run in 2014. Speaking to the Bulletin, the NA62 technical coordinator Ferdinand Hahn shares the many challenges that the various teams faced to be on time for beam. Ready, steady, start!   A Large Angle Veto detector (white) in place in the NA62 decay volume (blue). With components from almost all the detectors in place downstream of the decay point of the mother particles – the kaons – and of the KTAG detector that tags the kaons before they decay, NA62 is ready for its first technical run. This unique run will test all the equipment as well as the trigger and the data acquisition systems. “This year, we will have about five weeks of beam from the SPS before the long shutdown of all the CERN machines,” says Ferdinand Hahn, NA62 Technical Co-...

  12. Kostel na Lesné

    OpenAIRE

    Pospíšil, Vojtěch

    2017-01-01

    Tato teoretická diplomová práce se zabývá prostorovou akustikou a s tím úzce spojenou problematikou doby dozvuku. Součástí práce je zpracování návrhu akustických úprav kostela na základě ručního výpočtu, který byl dále upravován ve specializovaném softwaru Odeon Room Acoustics Program. Pro okolní zástavbu kostela byla vytvořena hluková studie v programu Hluk+, aby bylo posouzeno, jaký bude mít tato novostavba hlukový dopad z kostelních zvonů dopad na své okolí. Na základě specializace, bylo v...

  13. gigapanorama of NA 62 cavern

    CERN Multimedia

    Brice, Maximilien

    2015-01-01

    The image shows the new rare Kaon decay experiment at CERN, called NA62. The NA62 experiment is 270 metres long and includes a 120-metre-long vacuum tank, shown here, housing several of the particle detectors. (Note: the experiment axis is a straight line, the curving of the tank is an optical effect of the photo.) Kaons are particles that decay into lighter elementary particles. The kaon decay processes are mostly well known, except for some very rare decay modes. For example, NA62 is investigating a rare decay predicted by the Standard Model in which a kaon decays into one pion and two neutrinos. This process occurs only once every 10 billion decays. The understanding of such ultra-rare decays are of great importance because they test the Standard Model in energy ranges not accessible by direct measurements. They are therefore complementary to the measurements at the LHC. ultra high definition on demand (photolab@cern.ch).

  14. OGLAŠEVANJE NA FACEBOOKU

    OpenAIRE

    Renko, Katica

    2013-01-01

    V magistrskem delu smo se seznanili z oglaševanjem na Facebooku. S pregledom gradiva, ki nam je ponujeno, smo preverili pogoje, načine, oblike … oglaševanja, ki pa smo jih s pregledom situacije v praksi preverili in dopolnili. Ob zaključku dela lahko rečemo, da je oglaševanje preko FB enostavnejše, cenejše, dostopnejše, omogoča nam ažurnost in samo komunikacijo z naslovniki, ki so potencialni kupci naših ponudb. Množični mediji nam omogočajo mnogotero obliko oglaševanja. Izbrana oblika ponuja...

  15. NA60 frees the quarks

    CERN Multimedia

    2003-01-01

    Fitted with new state-of-the-art silicon detectors, NA60 is prepared to study the phase transition from confined hadronic matter to a deconfined (free) quark-gluon plasma, a state of matter which probably existed an instant after the Big Bang.

  16. Hodler et Iéna

    OpenAIRE

    2017-01-01

    Suites de la protestation contre le bombardement de la cathédrale de Reims. Le recteur de l'Université de Jena propose d'enlever le tableau monumental de Hodler "Départ des étudiants d'Iéna pour la guerre de libération contre Napoléon en 1813".

  17. NA62: Hidden Sector Physics

    CERN Document Server

    Cesarotti, Carissa Joyce

    2016-01-01

    Modern experimental physics is often probing for new physics by either finding deviations from predictions on extremely precise measurements, or by looking for a new signal that cannot be explained with existing models. The NA62 experiment at CERN does the former by measuring the ultra-rare decay $K^+ \\rightarrow \\pi^+ \

  18. The system NaVO3-Na2WO4-Na2W2O7

    International Nuclear Information System (INIS)

    Kazanbekov, V.R.; Gasanaliev, A.M.; Kazanbekov, R.G.

    1994-01-01

    Phase diagrams of sodium metavanadate-sodium ditungstate, sodium metavanadate-sodium tungstate systems and surface of primary crystallization of sodium metavabadate-sodium tungstate-sodium ditungstate system were studied. The system sodium metavanadate-sodium ditungstate is eutectic one. Compound NaVO 3 x2Na 2 WO 4 is formed in solid state in sodium metavanadate-sodium tungstate system. Liquidus surface of sodium metavanadate-sodium tungstate-sodium ditungstate is presented by three crystallization fields of initial components. Composition and melting point of ternary eutectics are determined

  19. prognosis of senile cataract extraction with increasing age

    African Journals Online (AJOL)

    Some of the risk factors are age (the strongest risk factor), diabetes mellitus, sunlight, steroids, nutrition, smoking and .... independent effect of these anatomical and neural changes result in decreased visual acuity with increasing age . .... and short term memory. In R. Sekuler D. Kline, and K. Dismukes (Edn.), Aging and ...

  20. ASSESSMENT OF PLASMA ZINC STATUS OF SENILE CATARACT ...

    African Journals Online (AJOL)

    ... function and cellular metabolism like protection of lens from oxidative damage and photochemistry of vision. Deficiency of zinc may be due to decreased intake, metabolic disorders, poor absorption and medication and may result in prolonged dark adaptation time, night blindness, retinal degenerations and cataract.

  1. How masticatory function and periodontal disease relate to senile dementia

    Directory of Open Access Journals (Sweden)

    Yutaka Watanabe, PhD, DDS

    2015-02-01

    Full Text Available This study reviews the research of dementia, a pathology for which numerous studies have found associations with masticatory function in the elderly. These issues are presently major problems in geriatric medical and welfare settings, and we discuss the prospects for future research into mastication. Dementia and masticatory function have been examined in a range of epidemiological and neuroscientific studies, and associations between the two have been reported. However, a causal relationship has not been satisfactorily established. Biochemical studies have also clarified the basis of the association between dementia and periodontal disease, but have not yet yielded sufficient evidence. Studies offering a high level of evidence, such as intervention studies and meta-analyses, are expected to be undertaken in this area in the future. Maintenance and recovery of masticatory function is of great importance with respect to achieving healthy longevity. Dental science will have considerable obligations and will have to take on an important role in this regard. For dental treatment to take on such important roles in the fields of health, medicine and welfare, it is necessary to provide information that will be understood not just by other medical and healthcare professionals, but also by the general public.

  2. SENILE DEGENERATIVE CHANGES IN ADULT LUMBAR SPINE! - A PROSPECTIVE STUDY

    Directory of Open Access Journals (Sweden)

    Garjesh Singh

    2015-11-01

    Full Text Available : BACKGROUND: Low back pain (LBP is a common presenting complaint affecting mostly middle aged and older person and traditionally considered as ageing process, but now-a-days large number of younger people are also affected by this debilitating chronic disorder. The cause of early onset of degenerative spine disease is multifactorial, but genetical predisposition plays very important role. AIMS AND OBJECTIVE: To find out association between genetic predisposition and degenerative spine disease in adult patients and to assess the pattern of MRI findings of various degenerative diseases in lumbo-sacral spine. MATERIAL AND METHOD: The present cross-sectional study had been performed among 100 selected patients in 1yr period, who presented with chief complaint of chronic low back pain. After taking detailed clinical and professional history, MRI of lumbosacral spine had been performed. Total 100 patients were divided in two groups on the basis of genetical predisposition. Prevalence and spectrum of degenerative changes were compared between both groups. RESULTS: Hundred patients of 20 to 35-year age had been selected with mean age of 27yr. Out of 100 patients; 47 were male and 53 were female. The most common degenerative findings were desiccation of disc (95% followed by disc bulge, herniation, spinal canal stenosis, ligamentum flavum hypertrophy, facet joint hypertrophy and modic changes. L4-L5 and L5- S1 were the most commonly involved spinal levels for any degenerative pathology. CONCLUSION: Good association is seen between early onset of degenerative spine disease and genetical predisposition in patients who have history of similar type degenerative spine disease in one or more first degree relatives in comparison to those patients who do not have any genetical predisposition. So it can be concluded that heredity play important role in early onset of degenerative spine disease in adults.

  3. Nanotherapy for Alzheimer's disease and vascular dementia: Targeting senile endothelium.

    Science.gov (United States)

    D'Arrigo, Joseph S

    2018-01-01

    Due to the complexity of Alzheimer's disease, multiple cellular types need to be targeted simultaneously in order for a given therapy to demonstrate any major effectiveness. Ultrasound-sensitive coated microbubbles (in a targeted lipid nanoemulsion) are available. Versatile small molecule drug(s) targeting multiple pathways of Alzheimer's disease pathogenesis are known. By incorporating such drug(s) into the targeted "lipid-coated microbubble" [LCM]/"nanoparticle-derived" [ND] (or LCM/ND) nanoemulsion type, one obtains a multitasking combination therapeutic for translational medicine. This multitasking therapeutic targets cell-surface scavenger receptors (mainly class B type I), or SR-BI, making possible for various Alzheimer's-related cell types to be simultaneously searched out for localized drug treatment in vivo. Besides targeting cell-surface SR-BI, the proposed LCM/ND-nanoemulsion combination therapeutic(s) include a characteristic lipid-coated microbubble [LCM] subpopulation (i.e., a stable LCM suspension); such film-stabilized microbubbles are well known to substantially reduce the acoustic power levels needed for accomplishing temporary noninvasive (transcranial) ultrasound treatment, or sonoporation, if additionally desired for the Alzheimer's patient. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Senile dementia and glaucoma: Evidence for a common link

    Directory of Open Access Journals (Sweden)

    Sachin Jain

    2015-01-01

    Full Text Available Dementia and glaucoma are both neurodegenerative conditions characterized by neuronal loss leading to cognitive and visual dysfunction, respectively. A variety of evidence exists linking the two diseases including structural signs, specifically degenerative changes within ganglion cells. Both diseases become more prevalent with increased age, but that alone is unlikely to account for the increased co-prevalence of the diseases found in various studies. Neurotoxic substances including abnormal hyperphosphorylated tau and amyloid-β have been found in both disease processes suggesting possible pathophysiologic links between the diseases. The exact mechanism of apoptosis, whether by direct toxicity or potentiation, still needs to be established, but could prove important for both diseases. Another potential link relates to low intracranial pressure in patients with both diseases causing a high translaminar pressure gradient and optic nerve damage in certain patients. While this alone may not account for direct optic nerve damage, it could lead to cerebrospinal fluid (CSF circulatory failure causing increased neurotoxins along the optic nerves with resultant damage. All of this evidence suggests the need to further study links between the two diseases, as this could prove instrumental in understanding their overlapping pathophysiology and developing directed therapies for both diseases. While this is more thoroughly investigated, it may be prudent to have a lower threshold for a glaucoma work-up in patients with pre-existing dementia.

  5. The role of brain imaging for diagnosis of senile dementia

    International Nuclear Information System (INIS)

    Nishino, Hideo

    1988-01-01

    X-ray computed tomography (CT) was performed in a total of 239 patients, consisting of 100 with dementia and 139 normal volunteers. In the normal group, small infarcted areas were observed in 20%, and dilatation of the lateral ventricle, cerebral sulci and Sylvian fissure was associated with aging. In the dementia group, the incidence of periventricular lucency was closely related to cerebrovascular disorder, and also increased with aging for Alzheimer type dimentia; dilatation of the lateral ventricle, cerebral sulci, Sylvian fissure, and third ventricle was unrelated to aging; the incidence of dilated lateral ventricle and Sylvian fissure was frequently observed when cerebrovascular disorder was associated; an atrophied medial temporal lobe was observed in patients with presenile dementia under the age of 60. Radionuclide cisternography for 145 patients with various diseases and 56 normal subjects revealed: ventricular reflux was observed in 50% of the total cases; it occurred in 50% in each group with either cerebrovascular disorder or non-cerebrovascular disorder; persistent ventricular reflux with Sylvian block was observed in 40% of cases of subarachnoid hemorrhage; and ventricular reflux in the elderly was considered attributable to pseudo-normal pressure hydrocephalus. Single photon emission computed tomography with I-123 IMP, performed in 11 dementia and 5 non-dementia patients, revealed a decreased uptake in the temporo-parietal region only in cases of Alzheimer type dementia, although there was no abnormal X-ray CT finding. (Namekawa, K) 51 refs

  6. Prevalence de la cataracte senile dans une population rurale du ...

    African Journals Online (AJOL)

    But: Evaluer la prévalence de la cataracte sénile dans le canton de Kévé, préfecture de l'Avé au Togo. Méthodologie: Il s'agit d'une étude transversale dans trois villages et le centre ville de Kévé. Les patients étaient regroupés et examinés à la lumière du jour à l'aide d'une lampe torche et un ophtalmoscope direct à piles ...

  7. Europlanet NA2 Science Networking

    Science.gov (United States)

    Harri, Ari-Matti; Szego, Karoly; Genzer, Maria; Schmidt, Walter; Krupp, Norbert; Lammer, Helmut; Kallio, Esa; Haukka, Harri

    2013-04-01

    Europlanet RI / NA2 Science Networking [1] focused on determining the major goals of current and future European planetary science, relating them to the Research Infrastructure that the Europlanet RI project [2] developed, and placing them in a more global context. NA2 also enhanced the ability of European planetary scientists to participate on the global scene with their own agenda-setting projects and ideas. The Networking Activity NA2 included five working groups, aimed at identifying key science issues and producing reference books on major science themes that will bridge the gap between the results of present and past missions and the scientific preparation of the future ones. Within the Europlanet RI project (2009-2012) the NA2 and NA2-WGs organized thematic workshops, an expert exchange program and training groups to improve the scientific impact of this Infrastructure. The principal tasks addressed by NA2 were: • Science activities in support to the optimal use of data from past and present space missions, involving the broad planetary science community beyond the "space club" • Science activities in support to the preparation of future planetary missions: Earth-based preparatory observations, laboratory studies, R&D on advanced instrumentation and exploration technologies for the future, theory and modeling etc. • Develop scientific activities, joint publications, dedicated meetings, tools and services, education activities, engaging the public and industries • Update science themes and addressing the two main scientific objectives • Prepare and support workshops of the International Space Science Institute (ISSI) in Bern and • Support Trans National Activities (TNAs), Joined Research Activities (JRAs) and the Integrated and Distributed Information Service (IDIS) of the Europlanet project These tasks were achieved by WG workshops organized by the NA2 working groups, by ISSI workshops and by an Expert Exchange Program. There were 17 official WG

  8. Na+-stimulated ATPase of alkaliphilic halotolerant cyanobacterium Aphanothece halophytica translocates Na+ into proteoliposomes via Na+ uniport mechanism

    Directory of Open Access Journals (Sweden)

    Soontharapirakkul Kanteera

    2010-08-01

    Full Text Available Abstract Background When cells are exposed to high salinity conditions, they develop a mechanism to extrude excess Na+ from cells to maintain the cytoplasmic Na+ concentration. Until now, the ATPase involved in Na+ transport in cyanobacteria has not been characterized. Here, the characterization of ATPase and its role in Na+ transport of alkaliphilic halotolerant Aphanothece halophytica were investigated to understand the survival mechanism of A. halophytica under high salinity conditions. Results The purified enzyme catalyzed the hydrolysis of ATP in the presence of Na+ but not K+, Li+ and Ca2+. The apparent Km values for Na+ and ATP were 2.0 and 1.2 mM, respectively. The enzyme is likely the F1F0-ATPase based on the usual subunit pattern and the protection against N,N'-dicyclohexylcarbodiimide inhibition of ATPase activity by Na+ in a pH-dependent manner. Proteoliposomes reconstituted with the purified enzyme could take up Na+ upon the addition of ATP. The apparent Km values for this uptake were 3.3 and 0.5 mM for Na+ and ATP, respectively. The mechanism of Na+ transport mediated by Na+-stimulated ATPase in A. halophytica was revealed. Using acridine orange as a probe, alkalization of the lumen of proteoliposomes reconstituted with Na+-stimulated ATPase was observed upon the addition of ATP with Na+ but not with K+, Li+ and Ca2+. The Na+- and ATP-dependent alkalization of the proteoliposome lumen was stimulated by carbonyl cyanide m - chlorophenylhydrazone (CCCP but was inhibited by a permeant anion nitrate. The proteoliposomes showed both ATPase activity and ATP-dependent Na+ uptake activity. The uptake of Na+ was enhanced by CCCP and nitrate. On the other hand, both CCCP and nitrate were shown to dissipate the preformed electric potential generated by Na+-stimulated ATPase of the proteoliposomes. Conclusion The data demonstrate that Na+-stimulated ATPase from A. halophytica, a likely member of F-type ATPase, functions as an electrogenic Na

  9. Photodesorption of Na atoms from rough Na surfaces

    DEFF Research Database (Denmark)

    Balzer, Frank; Gerlach, R.; Manson, J.R.

    1997-01-01

    We investigate the desorption of Na atoms from large Na clusters deposited on dielectric surfaces. High-resolution translational energy distributions of the desorbing atoms are determined by three independent methods, two-photon laser-induced fluorescence, as well as single-photon and resonance......-enhanced two-photon ionization techniques. Upon variation of surface temperature and for different substrates (mica vs lithium fluoride) clear non-Maxwellian time-of-flight distributions are observed with a cos θ angular dependence and most probable kinetic energies below that expected of atoms desorbing from...... atoms are scattered by surface vibrations. Recent experiments providing time constants for the decay of the optical excitations in the clusters support this model. The excellent agreement between experiment and theory indicates the importance of both absorption of the laser photons via direct excitation...

  10. Photodesorption of Na atoms from rough Na surfaces

    DEFF Research Database (Denmark)

    Balzer, Frank; Gerlach, R.; Manson, J.R.

    1997-01-01

    atoms are scattered by surface vibrations. Recent experiments providing time constants for the decay of the optical excitations in the clusters support this model. The excellent agreement between experiment and theory indicates the importance of both absorption of the laser photons via direct excitation......We investigate the desorption of Na atoms from large Na clusters deposited on dielectric surfaces. High-resolution translational energy distributions of the desorbing atoms are determined by three independent methods, two-photon laser-induced fluorescence, as well as single-photon and resonance......-enhanced two-photon ionization techniques. Upon variation of surface temperature and for different substrates (mica vs lithium fluoride) clear non-Maxwellian time-of-flight distributions are observed with a cos θ angular dependence and most probable kinetic energies below that expected of atoms desorbing from...

  11. Obiteljska i bračna psihoterapija

    OpenAIRE

    Štalekar, Vlasta

    2010-01-01

    U radu je ukratko prikazana povijest obiteljske terapije na temelju koje se prati razvoj novih koncepata i terapijskih modela. Prikazana je podjela obiteljskih i bračnih terapija na brojne pravce, a navedene u ovom radu su sistemska, dinamska, strukturalna, strateška, transgeneracijska, iskustvena (prvenstveno je didaktičkog karaktera jer se u praksi ovi modeli uvelike preklapaju i nadopunjuju). Svaki terapijski model na jedinstven način tumači disfunkcije obiteljskog sustava t...

  12. Novel aspects of Na+,K+-ATPase

    OpenAIRE

    Aizman, Oleg

    2002-01-01

    Na,K-ATPase, an integral membrane protein expressed in each eukaryotic cell, serves as the major determinant of intracellular ion composition. In the current study we investigated novel aspects of Na,K-ATPase function and regulation. It is well established that Na,K-ATPase activity is regulated by reversible phosphorylation. New findings in this study are: 1) the level of intracellular Ca 2. concentration determines the functional effects of PKA and PKC-mediated Na,K-ATP...

  13. Carne suína

    OpenAIRE

    Ortigara, Claudino

    2000-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. A carne suína é a fonte de proteína animal mais consumida no mundo. No entanto, em muitos países e em especial no Brasil o consumo per capita é muito baixo. Como conseqüência disso, limita-se o crescimento do segmento produtivo e uma série de benefícios socioeconômicos que são gerados pela atividade suinocultura.Com esse trabalho, buscamos uma explicação para entender a resistência da população ao consum...

  14. Economia na consulta de Endodontia

    OpenAIRE

    Pinto, Diogo Filipe Cardoso

    2016-01-01

    Introdução: Em Portugal a realidade actual, clínica e financeira do exercício da Medicina Dentária é bem distinta da do final do séc. XX devido à pletora de Médicos Dentistas e à baixa de honorários por acto Médico registada nos últimos anos. Objectivos: Este trabalho teve como objectivo perceber um pouco sobre os detalhes a ter em consideração aquando da abertura de uma clínica centrada na realização de tratamentos na área da Endodontia, e como publicitá-la de forma legal e apelativa. Pre...

  15. A Umbanda Portuguesa na Internet

    Directory of Open Access Journals (Sweden)

    Ismael Pordeus Júnior

    2004-01-01

    Full Text Available A partir de considerações sobre o processo de transculturação da Umbanda de Omolocô vou a propósito do grupo religioso do Terreiro de Umbanda Ogum Megê em Lisboa - Portugal discutir a textualização da memória. Como outras religiões que visam hoje o universal a Umbanda utiliza novas tecnologias disponíveis na Internet. Esse novo meio de comunicação favorece o processo de transculturação religiosa. Utilizando uma abordagem antropológica procuro realizar um estudo dos sites da Umbanda portuguesa na Internet, propondo uma visão ampla da utilização de novas tecnologias utilizadas para difusão da religião. Opto pelo estudo de caso, pois penso que permite uma melhor abordagem desse campo tecnológico.

  16. Otto Richard Gottlieb na UFRRJ

    OpenAIRE

    Raimundo Braz Filho; Universidade Estadual do Norte Fluminense Darcy Ribeiro; Mário Geraldo de Carvalho; Universidade Federal Rural do Rio de Janeiro

    2011-01-01

    Informações importantes da trajetória científica e produtiva do Prof. Otto Richard Gottlieb e sobre seu legado são revelados por dois de seus ex-alunos. Revelam sua perseverança na criação de grupos comprometidos com pesquisas em produtos naturais no Brasil. Inicialmente na Universidade de Brasília (UnB) e, em consequência de pressões políticas da década de sessenta, seu grupo deslocou-se para outras instituições recebendo apoio da Universidade Federal de Minas Gerais (UFMG), do Centro de Pes...

  17. Makosa Yanayofanywa na Wanafunzi Wanaojifunza Kiswahili kama ...

    African Journals Online (AJOL)

    Makala haya, yanashughulika na makosa ambayo hufanywa na wanafunzi wanaojifunza Kiswahili kama lugha ya pili katika shule za sekondari nchini Uganda. Mtafiti ameyaainisha makosa mbalimbali na kuyaeleza kiusahihi. Makala yanaeleza namna ambavyo makosa hayo hutokea. Yaani, kama ni makosa ...

  18. NA50 quark-gluon plasma experiment

    CERN Multimedia

    1997-01-01

    View of the NA50 detector, which studies quark-gluon plasma. The picture shows one of the six hodoscopes, made of 48 scintillator counters, used in the muon trigger of the NA50 spectrometer. The picture shows one of the six hodoscopes, made of 48 scintillator counters, used in the muon trigger of the NA50 spectrometer

  19. Pseudo-ternary phase diagram in the Na2O-Na2O2-NaOH system

    International Nuclear Information System (INIS)

    Saito, Jun-ichi; Tendo, Masayuki; Aoto, Kazumi

    1997-10-01

    Generally, the phase diagrams are always used to understand the present state of compounds at certain temperature. In order to understand the corrosion behavior of structural material for FBR by main sodium compounds (Na 2 O, Na 2 O 2 and NaOH), it is very important to comprehend the phase diagrams of their compounds. However, only Na 2 O-NaOH pseudo-binary phase diagram had been investigated previously in this system. There is no study of other pseudo-binary or ternary phase diagrams in the Na 2 O-Na 2 O 2 -NaOH system. In this study, in order to clarify the present states of their compounds at certain temperatures, the pseudo-binary and ternary phase diagrams in the Na 2 O-Na 2 O 2 -NaOH system were prepared. A series of thermal analyses with binary and ternary component system has been carried out using the differential scanning calorimetry (DSC). The liquidus temperature and ternary eutectic temperatures were confirmed by these measurements. The beneficial indications for constructing phase diagrams were obtained from these experiments. On the basis of these results, the interaction parameters between compounds which were utilized for the Thermo-Calc calculation were optimized. Thermo-Calc is one of thermodynamic calculation software. Consequently the accurate pseudo-binary and ternary phase diagrams were indicated using the optimized parameters. (author)

  20. Homocisteína Homocysteine

    Directory of Open Access Journals (Sweden)

    Lindalva Batista Neves

    2004-10-01

    Full Text Available A homocisteína, formada a partir da metionina hepática, é metabolizada nas vias de desmetilação e de transulfuração, sendo que seus valores plasmáticos e urinários refletem a síntese celular. Sua determinação, realizada em jejum e após sobrecarga de metionina, caracteriza as diferenças dessas vias metabólicas, principalmente quando de natureza genética. A hiper-homocisteinemia tem sido associada a maior risco de eventos aterotrombóticos, e a literatura sugere associação causal, independente de outros fatores de risco para doença arterial. Diminuição da homocisteína plasmática para valores normais é seguida de redução significante na incidência de doença aterotrombótica. A relação entre homocisteína e o fígado vem adquirindo importância nos dias atuais, uma vez que alterações das lipoproteínas e da depuração de metionina são comuns em pacientes com doença hepática crônica (hepatocelular e canalicular. O tratamento da hiper-homocisteinemia fundamenta-se na suplementação alimentar e medicamentosa de ácido fólico e vitaminas B6 e B12.Homocysteine, formed from hepatic methionine, is metabolized through the pathways of demethylation and transsulfuration. Its plasmatic and urinary values reflect the cell synthesis. Its determination after fasting and increased infusion of methionine shows the differences of these two metabolic pathways, mainly when it is related to genetic diseases. Hyperhomocysteinemia has been associated with a higher risk of vascular thrombotic events. Several authors suggest a causal relationship between these events independently of other risk factors for vascular diseases. Decrease in plasmatic homocysteine to normal levels is followed by a significant reduction on the incidence of vascular thrombotic events. The correlation between the liver and homocysteine is becoming more important because of the recent findings that alterations of lipoproteins and methionine clearance are

  1. Myocardial Na,K-ATPase: Clinical aspects

    OpenAIRE

    Kjeldsen, Keld

    2003-01-01

    The specific binding of digitalis glycosides to Na,K-ATPase is used as a tool for Na,K-ATPase quantification with high accuracy and precision. In myocardial biopsies from patients with heart failure, total Na,K-ATPase concentration is decreased by around 40%; a correlation exists between a decrease in heart function and a decrease in Na,K-ATPase concentration. During digitalization, around 30% of remaining pumps are occupied by digoxin. Myocardial Na,K-ATPase is also influenced by other drugs...

  2. Istraživanje uticaja nekih parametara na osetljivost eksplozivnih materija na toplotni impuls

    OpenAIRE

    Jeremić Radun

    2002-01-01

    Ispitivana je osetljivost nekoliko vrsta eksplozivnih materija na toplotni impuls merenjem vremena zadrške u zavisnosti od temperature. Na osnovu eksperimentalnih rezultata određene su vrednosti energije aktivacije i predeksponencijalni faktori u jednačini Semjonova. Istraživan je i uticaj mase ispitivanog uzorka, granulacije i veličine kristala eksploziva na osetljivost na toplotni impuls. Pokazano je da ovi parametri imaju značajan uticaj na osetljivost eksplozivnih materija, pa je neophodn...

  3. Silicene for Na-ion battery applications

    KAUST Repository

    Zhu, Jiajie

    2016-08-19

    Na-ion batteries are promising candidates to replace Li-ion batteries in large scale applications because of the advantages in natural abundance and cost of Na. Silicene has potential as the anode in Li-ion batteries but so far has not received attention with respect to Na-ion batteries. In this context, freestanding silicene, a graphene-silicene-graphene heterostructure, and a graphene-silicene superlattice are investigated for possible application in Na-ion batteries, using first-principles calculations. The calculated Na capacities of 954mAh/g for freestanding silicene and 730mAh/g for the graphenesilicene superlattice (10% biaxial tensile strain) are highly competitive and potentials of >0.3 V against the Na/Na potential exceed the corresponding value of graphite. In addition, the diffusion barriers are predicted to be <0.3 eV.

  4. Hali ya taaluma ya ukalimani Tanzania: jana, leo na kesho ...

    African Journals Online (AJOL)

    Umuhimu wa ukalimani katika mawasiliano umeongezeka kutokana na utandawazi. Utandawazi umerahisisha kukutanika na kuwasiliana kwa watu wazungumzao lugha tofauti kupitia wakalimani. Kutokana na ongezeko hilo la umuhimu wa ukalimani, kumekuwa na jitihada mbalimbali katika nchi mbalimbali kuhakikisha ...

  5. Docência na universidade: professores inovadores na USP

    Directory of Open Access Journals (Sweden)

    Chamlian Helena Coharik

    2003-01-01

    Full Text Available O artigo trata de pesquisa realizada com um grupo de professores inovadores da Universidade de São Paulo tendo como objetivo procurar subsídios para a formação do professor universitário. Esses docentes foram entrevistados, solicitando que detalhassem melhor suas experiências inovadoras; explicassem as razões pelas quais haviam introduzido modificações em sua forma de trabalho; explicitassem as relações entre sua atividade de docência e de pesquisa, expressassem o papel que atribuíam ao ensino na universidade, bem como a forma pela qual sua trajetória acadêmica havia se cumprido até então. A diversidade de experiências relatadas e, ao mesmo tempo, a convergência de visões a respeito de suas funções de ensino e de pesquisa na universidade permitem-nos afirmar que, mais do que uma formação pedagógica específica, a sensibilização para as dificuldades do ensino e a valorização institucional dessa atividade consistiriam em grande avanço para a formação do professor.

  6. Na alvorada de um sport

    OpenAIRE

    Sartori, Carina

    2013-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas, Programa de Pós-graduação em História, Florianópolis, 2013 Em Florianópolis, a primeira Sociedade de Regatas organizada, meados do século XIX, contaria com a participação dos Coronéis da Marinha e da Escola de Menores e Marinheiros da Canhoneira. Na virada do século, a fundação do Clube 29 de Abril permitiria que as atividades relacionadas ao Remo fossem oferecidas a todos que se associ...

  7. A Umbanda Portuguesa na Internet

    OpenAIRE

    Ismael Pordeus Júnior

    2004-01-01

    A partir de considerações sobre o processo de transculturação da Umbanda de Omolocô vou a propósito do grupo religioso do Terreiro de Umbanda Ogum Megê em Lisboa - Portugal discutir a textualização da memória. Como outras religiões que visam hoje o universal a Umbanda utiliza novas tecnologias disponíveis na Internet. Esse novo meio de comunicação favorece o processo de transculturação religiosa. Utilizando uma abordagem antropológica procuro realizar um estudo dos sites da Umbanda portuguesa...

  8. Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease

    DEFF Research Database (Denmark)

    Toustrup-Jensen, Mads Schak; Einholm, Anja P.; Schack, Vivien

    2014-01-01

    The neurological disorders familial hemiplegic migraine type 2 (FHM2), alternating hemiplegia of childhood (AHC), and rapid-onset dystonia parkinsonism (RDP) are caused by mutations of Na+,K+-ATPase α2- and α3-isoforms, expressed in glial and neuronal cells, respectively. Although these disorders......, addressing the question to what extent they cause a change of the intracellular Na+ and K+ concentrations ([Na+]i and [K+]i) in COS cells. C-terminal extension mutants generally showed dramatically reduced Na+ affinity without disturbance of K+ binding, as did other RDP mutants. No phosphorylation from ATP...... was observed for the +28 mutation of α2, despite a high expression level. A significant rise of [Na+]i and reduction of [K+]i was detected in cells expressing mutants with reduced Na+ affinity, and did not require a concomitant reduction of the maximal catalytic turnover rate or expression level. Moreover, two...

  9. O ATLETISMO NA PERSPECTIVA EDUCACIONAL

    Directory of Open Access Journals (Sweden)

    Leandro Araujo de Sousa

    2017-06-01

    Full Text Available A educação física escolar deve proporcionar experiências aos alunos para o seu desenvolvimento integral. As aulas muitas vezes são reduzidas ao ensino de esportes tradicionais, o que limita o repertório de movimentos dos alunos. Dessa forma o presente estudo de revisão objetiva problematizar o atletismo no ambiente escolar e propor possibilidades pedagógicas para seu ensino. Nesta pesquisa propomos tratar o ensino do atletismo na escola, caracterizando-o pelo seu repertório de movimentos que são naturais ao ser humano, como correr, saltar e lançar, o que possibilita maior praticidade em sua aplicação pedagógica, porém essas possibilidades não são consideradas no ambiente educacional. Diante dos dados encontrados, sugerimos que esse esporte seja abordado de forma multidimensional no ambiente escolar contextualizando-o à visão de algumas correntes teóricas. Nessa perspectiva do esporte educacional, o atletismo pode, assim como deve ser trabalhado nas aulas de educação física como instrumento pedagógico de ensino e auxiliar na formação do aluno de forma global.

  10. Identidades Homossexuais na Territorialidade Tradicionalista

    Directory of Open Access Journals (Sweden)

    Edipo Djavan dos Reis Göergen

    2015-12-01

    Full Text Available Este artigo apresenta o debate teórico que sustenta a pesquisa de mestrado desenvolvida pelo autor. Tendo por base suas vivências em contextos de tradicionalismo gaúcho, o autor deste trabalho tem percebido a grande quantidade de homossexuais, ou indivíduos que se auto-denominam não-heterossexuais, integrando as atividades artísticas do Movimento Tradicionalista Gaúcho, ou a territorialidade tradicionalista. Interessado em investigar tal fenômeno, o autor tem desenvolvido o projeto de pesquisa “Os Espaços Paradoxais de Relações Homoeróticas na Territorialidade Tradicionalista”, sob orientação do prof. Dr. Benhur Pinós da Costa, no Programa de Pós-Graduação em Geografia (UFSM. Para que essa pesquisa seja realizada, levam-se em conta as relações de gênero e de sexualidade que estão envolvidas no tema. Dessa forma, por ainda se tratarem de temáticas tidas como insignificantes na sociedade em geral e marginalizadas no campo científico, para que o presente trabalho fosse empreendido, buscou-se amparo teórico nas geografias feministas e queer, segmentos contemporâneos da ciência geográfica.

  11. Micotoxinas e Micotoxicoses na Avicultura

    Directory of Open Access Journals (Sweden)

    Santurio JM

    2000-01-01

    Full Text Available Esta revisão tem como objetivo principal mostrar, baseado em dezenas de pesquisas realizadas, os efeitos tóxicos das micotoxinas aflatoxinas, tricotecenos, zealenona e fumonisinas sobre o desempenho das aves. O descobrimento das propriedades hepatotóxicas e hepatocarcinogênicas de algumas linhagens de Aspergillus flavus e A. parasiticus em perus, na Inglaterra, no início da década de 1960, seguida pela elucidação da estrutura de seus metabólitos tóxicos, as aflatoxinas, deu novo enfoque e prioridade para a pesquisa sobre micotoxinas. Análises de aflatoxinas realizadas no Laboratório de Análises Micotoxicológicas (LAMIC da Universidade Fedaral de Santa Maria, entre os anos de 1986 e janeiro de 2000, em 15.600 amostras de alimentos destinados principalmente ao consumo animal, demonstram que no milho analisado, 41,9% das amostras estavam contaminadas por aflatoxinas. Em surtos de aflatoxicose no campo, uma das características mais marcantes é a má absorção que se manifesta como partículas de ração mal digeridas na excreta das aves. Também observa-se, em frangos e poedeiras que recebem AFL, extrema palidez das mucosas e pernas. Dietas deficientes em riboflavina ou colecalciferol (vit. D tornaram frangos sensíveis, nos índices de desenvolvimento corporal, a concentrações muito baixas de AFL. O efeito aflatoxina nos frangos é maior na fase inicial de crescimento, ou seja, quando as aves ingeriram aflatoxina nos primeiros 21 dias de vida, e quanto maior o nível de stress do lote, menor a quantidade de AFL para afetar negativamente seu desempenho, seja na produção de carne ou de ovos. As principais micotoxinas do grupo dos tricotecenos são: toxina T-2; deoxynivalenol (DON; diacetoxyscirpenol (DAS, todas produzidas através de diversas espécies de fungos do gênero Fusarium. Além dos tricotecenos, o fusarium também pode produzir zearalenona e fumonisinas. Dessas fusarium-toxinas, somente toxina T-2 gera patologias s

  12. Fotografia na Imprensa: conflitos na câmara escura

    Directory of Open Access Journals (Sweden)

    José Lúcio da Silva Menezes

    2014-07-01

    Full Text Available Este artigo recupera o teor ideológico do discurso que a Revista Veja elaborou sobre a classe trabalhadora que emergiu no cenário brasileiro, no final da década de 1970. O destaque dado aos trabalhadores como temática central resgatada, deve-se aos movimentos grevistas por eles encetados, após anos de ocultamento de sua resistência sob a repressão da ditadura civil-militar (1964-1985. Com a rebeldia operária, as matérias a respeito deste grupo, na Revista,foram se tornando mais constantes e visíveis, pois já não era mais possível, para a Revista Veja, ignorar a existência da classe operária que, com a força insurgente das greves, ocupava as ruas do Brasil.

  13. Vpliv toplotnih mostov na porabo energije za ogrevanje na primeru osnovne šole

    OpenAIRE

    Megušar, Primož

    2015-01-01

    Na primeru Osnovne šole Dobrova sem preveril, kakšen vpliv imajo dejanski toplotni mostovi na porabo energije za ogrevanje. Iz načrtov stavbe sem evidentiral vse toplotne mostove, kateri vplivajo na porabo energije. Tem toplotnim mostovom sem nato v standardu SIST EN ISO 14683 poiskal ustrezne približke. Nato sem s programom TOST izvedel tri simulacije. V prvem primeru toplotnih mostov nisem upošteval. V drugem primeru sem toplotne mostove upošteval na poenostavljen način, v zadnjem primeru p...

  14. Na and K dependence of the Na/K pump in cystic fibrosis fibroblasts.

    OpenAIRE

    Reznik, V M; Schneider, J A; Mendoza, S A

    1981-01-01

    The Na and K dependence of the Na/K pump was measured in skin fibroblasts from patients with cystic fibrosis and age/sex-matched controls. Under basal conditions, there was no difference between control and cystic fibrosis cells in protein per cell, intracellular Na and K content, or Na/K pump activity (measured as ouabain-sensitive 86Rb uptake). There was no difference in the Na dependence of the Na/K pump between cystic fibrosis cells and control cells. In cells from patients with cystic fi...

  15. Modification of single Na+ channels by batrachotoxin.

    Science.gov (United States)

    Quandt, F N; Narahashi, T

    1982-11-01

    The modifications in the properties of voltage-gated Na+ channels caused by batrachotoxin were studied by using the patch clamp method for measuring single channel currents from excised membranes of N1E-115 neuroblastoma cells. The toxin-modified open state of the Na+ channel has a decreased conductance in comparison to that of normal Na+ channels. The lifetime of the modified open state is drastically prolonged, and channels now continue to open during a maintained depolarization so that the probability of a channel being open becomes constant. Modified and normal open states of Na+ channels coexist in batrachotoxin-exposed membrane patches. Unlike the normal condition, Na+ channels exposed to batrachotoxin open spontaneously at large negative potentials. These spontaneous openings apparently cause the toxin-induced increase in Na+ permeability which, in turn, causes membrane depolarization.

  16. Low-spin states of 23Na

    International Nuclear Information System (INIS)

    Bakkum, E.L.

    1987-01-01

    A study of 23 Na via the 22 Ne(p,γ) 23 Na and 23 Na(γ,γ) 23 Na reactions is presented. Only a limited number of resonances has been studied, selected on the basis of strong excitation of the lowest levels of which the spin was unknown. As a result the spins are now known of all levels of 23 Na with excitation energies up to 7 MeV, except for a few high-spin states which are too weakly excited in the decay of the known 22 Ne(p,γ) resonances. The mean lifetimes of the 23 Na levels at 4.43 and 7.89 MeV were found to be 350±70 and 220±17 attoseconds (1 attosecond = 10 -18 seconds) respectively. 97 refs.; 22 figs.; 12 tabs

  17. Modification of single Na+ channels by batrachotoxin.

    OpenAIRE

    Quandt, F N; Narahashi, T

    1982-01-01

    The modifications in the properties of voltage-gated Na+ channels caused by batrachotoxin were studied by using the patch clamp method for measuring single channel currents from excised membranes of N1E-115 neuroblastoma cells. The toxin-modified open state of the Na+ channel has a decreased conductance in comparison to that of normal Na+ channels. The lifetime of the modified open state is drastically prolonged, and channels now continue to open during a maintained depolarization so that the...

  18. PRIMERJAVA GEODETSKIH METOD NA ZAHTEVNEM GRADBENEM OBJEKTU

    OpenAIRE

    Reberčnik, Matic

    2017-01-01

    V projektni nalogi smo v uvodnih poglavjih predstavili različne načine izvajanja geodetskih meritev, ki jih v gradbeništvu uporabljamo pri analizi pomikov in deformacij gradbenih konstrukcij ter terena, na katerem so le-te postavljene. V nadaljevanju opisujemo terestične in GNSS (globalni navigacijski satelitski sistem) metode, ki smo jih uporabljali pri izvajanju meritev na izbranem premostitvenem objektu avtocestnega odseka v Sloveniji (zaradi varovanja podatkov ga imenujemo Objekt 1). Pod...

  19. Ionic dependence of active Na-K transport: clamping of cellular Na+ with monensin

    International Nuclear Information System (INIS)

    Haber, R.S.; Pressley, T.A.; Loeb, J.N.; Ismail-Beigi, F.

    1987-01-01

    The Na + ionophore monensin was used to study the Na + - and K + -dependence of ouabain-inhibitable 86 Rb + uptake in ARL 15 cells, a rat liver cell line. Graded concentrations of monensin rapidly induced incremental elevations of cellular Na + that were stable for up to 2 h. In experiments in which cellular Na + was thus clamped at various levels, the activation curve for ouabain-inhibitable 86 Rb + uptake as a function of intracellular Na + was found to be steepest near basal Na + levels (Hill coefficient /congruent/ 2.4), indicating that these cells can respond to relatively large changes in passive Na + entry by increasing the rate of Na-K pump function with only minimal increases in cellular Na + . Exposure of cells to monensin also permitted examination of the extracellular-K + dependence of ouabain inhibitable 86 Rb + uptake in presence of saturating intracellular Na + and yielded a Hill coefficient of ∼ 1.5. The rate of ATP hydrolysis calculated from measurements of the maximal rate of ouabain-inhibitable 86 Rb + uptake in intact cells was similar to the enzymatic V/sub max/ of the Na + -K + -ATPase in cell lysates, suggesting that the Na + -K + -ATPase activity in these broken-cell preparations closely reflects the functional transport capacity of the Na-K pump

  20. Fabrication of implanted $^{22}$Na targets

    CERN Multimedia

    2002-01-01

    A knowledge of the $^{22}$Na(p,$\\gamma$)$^{23}$ Mg reaction rate is of significant astrophysical interest. In order to complete previous studies of this reaction, radioactive $^{22}$Na targets of high purity are required. We ask for support to fabricate these targets via the implantation technique at ISOLDE GPS (off—line mode) using $^{22}$Na nuclides in an Al matrix produced in Nov. 1990 at the PSI (Zürich). The $^{22}$Na nuclides are released and ionized in a surface ionisation source, mass-analyzed at ISOLDE GPS, and implanted in a Ni-Ta backing and a C—foil in a special implantation setup.

  1. OGLAŠEVANJE NA FACEBOOKU V SLOVENIJI

    OpenAIRE

    Dobnik, Monja

    2013-01-01

    Danes so zahvaljujoč napredni mobilni tehnologiji družbena omrežja z nami na vsakem koraku. Facebook (FB) se po priljubljenosti uvršča v sam vrh družbenih omrežij in glede na to, da ga uporablja že več kot milijarda zemljanov, ponuja tudi odlične trg za oglaševanje. To so ugotovili tudi slovenski podjetniki. V diplomski nalogi je predstavljeno, kako na FB oglašujejo nekatera slovenska podjetja, s pomočjo spletnega vprašalnika pa je ugotovljeno tudi, kaj o oglasih na FB menijo njegovi uporabni...

  2. Na+ Recirculation and Isosmotic Transport

    DEFF Research Database (Denmark)

    Larsen, Erik Hviid; Møbjerg, N

    2006-01-01

    of the absorbate. Mathematical modeling reproducing bioelectric and hydrosmotic properties of small intestine and proximal tubule, respectively, predicts a significant range of observations such as isosmotic transport, hyposmotic transport, solvent drag, anomalous solvent drag, the residual hydraulic permeability...... external baths. Hyperosmolarity of lis is governed by the hydraulic permeability of the apical plasma membrane and tight junction with 6-7 mOsm in small intestine and transport demands a Na(+) recirculation of 50-70% in small intestine but might be barely...... measurable in proximal tubule. The model fails to reproduce a certain type of observations: The reduced volume absorption at transepithelial osmotic equilibrium in AQP1 knockout mice, and the stimulated water absorption by gallbladder in diluted external solutions. Thus, it indicates cellular regulation...

  3. O consumo na vida digital

    Directory of Open Access Journals (Sweden)

    Iuri Yudi Furukita Baptista

    2016-02-01

    Full Text Available O modelo de consumo não possui as mesmas características sempre: suas relações, motivações, formatos, espaços, interesses e atividades são construções sociais que se modificam atreladas ao cenário econômico, político e tecnológico. O presente trabalho repassa o surgimento da sociedade do consumidor para então conjecturar sobre as propriedades distintivas do consumo na vida digital. O que se defende ao final é que o consumidor já não se restringe ao papel de consumir.

  4. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart

    Science.gov (United States)

    Shattock, Michael J; Ottolia, Michela; Bers, Donald M; Blaustein, Mordecai P; Boguslavskyi, Andrii; Bossuyt, Julie; Bridge, John H B; Chen-Izu, Ye; Clancy, Colleen E; Edwards, Andrew; Goldhaber, Joshua; Kaplan, Jack; Lingrel, Jerry B; Pavlovic, Davor; Philipson, Kenneth; Sipido, Karin R; Xie, Zi-Jian

    2015-01-01

    This paper is the third in a series of reviews published in this issue resulting from the University of California Davis Cardiovascular Symposium 2014: Systems approach to understanding cardiac excitation–contraction coupling and arrhythmias: Na+ channel and Na+ transport. The goal of the symposium was to bring together experts in the field to discuss points of consensus and controversy on the topic of sodium in the heart. The present review focuses on cardiac Na+/Ca2+ exchange (NCX) and Na+/K+-ATPase (NKA). While the relevance of Ca2+ homeostasis in cardiac function has been extensively investigated, the role of Na+ regulation in shaping heart function is often overlooked. Small changes in the cytoplasmic Na+ content have multiple effects on the heart by influencing intracellular Ca2+ and pH levels thereby modulating heart contractility. Therefore it is essential for heart cells to maintain Na+ homeostasis. Among the proteins that accomplish this task are the Na+/Ca2+ exchanger (NCX) and the Na+/K+ pump (NKA). By transporting three Na+ ions into the cytoplasm in exchange for one Ca2+ moved out, NCX is one of the main Na+ influx mechanisms in cardiomyocytes. Acting in the opposite direction, NKA moves Na+ ions from the cytoplasm to the extracellular space against their gradient by utilizing the energy released from ATP hydrolysis. A fine balance between these two processes controls the net amount of intracellular Na+ and aberrations in either of these two systems can have a large impact on cardiac contractility. Due to the relevant role of these two proteins in Na+ homeostasis, the emphasis of this review is on recent developments regarding the cardiac Na+/Ca2+ exchanger (NCX1) and Na+/K+ pump and the controversies that still persist in the field. PMID:25772291

  5. Analiza utjecaja stabilizatora na određivanje elemenata vanjske orijentacije kamere na bespilotnoj letjelici

    OpenAIRE

    Gašparović, Mateo; Gajski, Dubravko

    2016-01-01

    U radu su prikazani i interpretirani rezultati analize utjecaja stabilizatora kamere na određivanje elemenata vanjske orijentacije na bespilotnim letjelicama. Riječ je o 3-osnom stabilizatoru baziranom na elektromotorima bez četkica. Prikazan je i objašnjen koncept rada stabilizatora kamera na bespilotnim letjelicama. Za potrebe rada stabilizator je unaprijeđen upotrebom drugog inercijalnog mjernog uređaja (IMU). Provedena su dva testiranja stabilizatora upotrebom jednog i dva inercijalna mje...

  6. Na+,K+-ATPase Na+ affinity in rat skeletal muscle fiber types

    DEFF Research Database (Denmark)

    Kristensen, Michael; Juel, Carsten

    2010-01-01

    Previous studies in expression systems have found different ion activation of the Na(+)/K(+)-ATPase isozymes, which suggest that different muscles have different ion affinities. The rate of ATP hydrolysis was used to quantify Na(+),K(+)-ATPase activity, and the Na(+) affinity of Na(+),K(+)-ATPase......Previous studies in expression systems have found different ion activation of the Na(+)/K(+)-ATPase isozymes, which suggest that different muscles have different ion affinities. The rate of ATP hydrolysis was used to quantify Na(+),K(+)-ATPase activity, and the Na(+) affinity of Na......(+),K(+)-ATPase was studied in total membranes from rat muscle and purified membranes from muscle with different fiber types. The Na(+) affinity was higher (K(m) lower) in oxidative muscle compared with glycolytic muscle and in purified membranes from oxidative muscle compared with glycolytic muscle. Na......(+),K(+)-ATPase isoform analysis implied that heterodimers containing the beta(1) isoform have a higher Na(+) affinity than heterodimers containing the beta(2) isoform. Immunoprecipitation experiments demonstrated that dimers with alpha(1) are responsible for approximately 36% of the total Na,K-ATPase activity. Selective...

  7. Exploration of NaVOPO4 as a cathode for a Na-ion battery.

    Science.gov (United States)

    Song, Jie; Xu, Maowen; Wang, Long; Goodenough, John B

    2013-06-11

    Monoclinic NaVOPO4 is explored as a cathode material for a sodium ion battery. It exhibits electrochemical activity operating at an average potential of 3.6 V (vs. Na(+)/Na) and delivers a reversible capacity of 90 mA h g(-1) at 1/15 C.

  8. Study of the Na-C-O and Na-H-O ternary systems in the sodium rich corner

    International Nuclear Information System (INIS)

    Maupre, J.-P.

    1978-02-01

    The purpose of this study is to provide a contribution to the understanding of the sodium - carbon - oxygen and sodium - hydrogen - oxygen ternary systems in the sodium rich corner. In order to do this the Na-NaH-Na 2 O-NaOH phase diagram was completed and the Na-Na 2 O-Na 2 CO 3 -C phase diagram was outlined. This work is made up of two parts. The first is devoted to a critical literature survey essential to establish correct phase diagrams. The second is an experimental study followed by a discussion collating our finding to the literary data. The basic experimental technique used is differential thermal analysis (DTA) but it has been completed by quenching, X-ray and chemical analysis methods. The proposed phase diagrams imply that Na-NaH-Na 2 O-NaOH and Na-Na 2 O-Na 2 CO 3 -C systems are reciprocal ternary systems. Temperatures of stable pairs reversal are respectively 410 and 690 0 C. The stable pairs are Na-NaOH and Na-Na 2 CO 3 at elevated temperature, Na 2 O-NaH and Na 2 O-C at low temperature [fr

  9. OGLAŠEVANJE NA DRUŽBENIH OMREŽJIH NA PRIMERU FACEBOOKA

    OpenAIRE

    Novak, Martina

    2012-01-01

    V diplomskem delu obravnavamo družbene medije kot novo priložnost za promocijo in oglaševanje podjetij. Spoznali smo družbena omrežja na splošno in nekaj teh, ki jih uporabljamo tudi v Sloveniji na kratko predstavili. Podrobneje smo se osredotočili na družbeno omrežje Facebook, predvsem na samo spletno stran, njen izgled in storitve, ki jih ponuja uporabnikom. V nalogi je podrobneje opisan Facebook kot orodje za uporabo oglaševanja. Spoznali smo brezplačne in plačljive načine promocije in ogl...

  10. Alterações genéticas na doença de Alzheimer

    Directory of Open Access Journals (Sweden)

    Cintia Fridman

    2004-01-01

    Full Text Available Com o aumento da expectativa de vida, visto hoje em todo o planeta, um maior número de indivíduos alcança uma idade avançada em que a manifestação de doenças neurodegenerativas é mais freqüente. Entre essas, a doença de Alzheimer (DA é a causa mais freqüente de demência. Os achados mais marcantes na DA, em cérebros de pacientes acometidos pela doença, são as placas senis, os emaranhados neurofibrilares e a extensa perda neuronal. No entanto, existe uma carência generalizada de marcadores biológicos preditivos ou com valor diagnóstico para a DA. Estudos de genética molecular permitiram identificar quatro genes consistentemente associados com o maior risco de desenvolvimento da doença: APP, apoE, PSEN1 e PSEN2. No entanto, inúmeros estudos apontam para papel importante de outros genes, fortalecendo a hipótese de uma doença poligênica e multifatorial. Neste sentido, novas abordagens de estudo têm um futuro promissor, podendo indicar uma vasta população de genes ou alterações moleculares que possam explicar o surgimento da doença, vindo a fornecer as bases para a compreensão da DA e também para o delineamento de novas e mais eficazes abordagens de tratamento ou prevenção da doença.With the increase of the life expectancy that is seen today in the entire planet, a larger number of individuals reaches an advanced age when the manifestation of neurodegenerative illnesses is more frequent. Among these, the Alzheimer's disease (AD is the most common cause of dementia. The most substantial findings in the brains of patients suffering from AD are the senile plaques, the neurofibrillary tangles and an extensive neuronal loss. However, a general deficiency of predictive biological markers for AD impairs the correct diagnosis and the better understanding of the disease. Studies of molecular genetics allowed the identification of four genes that are consistently linked to AD: APP, apoE, PSEN1 and PSEN2. However, diverse

  11. Extracellular Na+ levels regulate formation and activity of the NaX/alpha1-Na+/K+-ATPase complex in neuronal cells.

    Directory of Open Access Journals (Sweden)

    Emmanuelle eBerret

    2014-12-01

    Full Text Available MnPO neurons play a critical role in hydromineral homeostasis regulation by acting as sensors of extracellular sodium concentration ([Na+]out. The mechanism underlying Na+-sensing involves Na+-flow through the NaX channel, directly regulated by the Na+/K+-ATPase α1-isoform which controls Na+-influx by modulating channel permeability. Together, these two partners form a complex involved in the regulation of intracellular sodium ([Na+]in. Here we aim to determine whether environmental changes in Na+ could actively modulate the NaX/Na+/K+-ATPase complex activity.We investigated the complex activity using patch-clamp recordings from rat MnPO neurons and Neuro2a cells. When the rats were fed with a high-salt-diet, or the [Na+] in the culture medium was increased, the activity of the complex was up-regulated. In contrast, drop in environmental [Na+] decreased the activity of the complex. Interestingly under hypernatremic condition, the colocalization rate and protein level of both partners were up-regulated. Under hyponatremic condition, only NaX protein expression was increased and the level of NaX/Na+/K+-ATPase remained unaltered. This unbalance between NaX and Na+/K+-ATPase pump proportion would induce a bigger portion of Na+/K+-ATPase-control-free NaX channel. Thus we suggest that hypernatremic environment increases NaX/Na+/K+-ATPase α1-isoform activity by increasing the number of both partners and their colocalization rate, whereas hyponatremic environment down-regulates complex activity via a decrease in the relative number of NaX channels controlled by the pump.

  12. K+ congeners that do not compromise Na+ activation of the Na+,K+-ATPase

    DEFF Research Database (Denmark)

    Mahmmoud, Yasser A; Kopec, Wojciech; Khandelia, Himanshu

    2015-01-01

    to no antagonism to cytoplasmic Na(+) activation. Na(+),K(+)-ATPase structures revealed a previously undescribed rotamer transition of the hydroxymethyl side chain of the absolutely conserved Thr(772) of the α-subunit. The side chain contributes its hydroxyl to Na(+) in site I in the E1 form and rotates......The Na(+),K(+)-ATPase is essential for ionic homeostasis in animal cells. The dephosphoenzyme contains Na(+) selective inward facing sites, whereas the phosphoenzyme contains K(+) selective outward facing sites. Under normal physiological conditions, K(+) inhibits cytoplasmic Na(+) activation...... to contribute its methyl group toward K(+) in the E2 form. Molecular dynamics simulations to the E1·AlF4 (-)·ADP·3Na(+) structure indicated that 1) bound organic cations differentially distorted the ion binding sites, 2) the hydroxymethyl of Thr(772) rotates to stabilize bound Form(+) through water molecules...

  13. Crystal structure of Na+, K(+)-ATPase in the Na(+)-bound state.

    Science.gov (United States)

    Nyblom, Maria; Poulsen, Hanne; Gourdon, Pontus; Reinhard, Linda; Andersson, Magnus; Lindahl, Erik; Fedosova, Natalya; Nissen, Poul

    2013-10-04

    The Na(+), K(+)-adenosine triphosphatase (ATPase) maintains the electrochemical gradients of Na(+) and K(+) across the plasma membrane--a prerequisite for electrical excitability and secondary transport. Hitherto, structural information has been limited to K(+)-bound or ouabain-blocked forms. We present the crystal structure of a Na(+)-bound Na(+), K(+)-ATPase as determined at 4.3 Å resolution. Compared with the K(+)-bound form, large conformational changes are observed in the α subunit whereas the β and γ subunit structures are maintained. The locations of the three Na(+) sites are indicated with the unique site III at the recently suggested IIIb, as further supported by electrophysiological studies on leak currents. Extracellular release of the third Na(+) from IIIb through IIIa, followed by exchange of Na(+) for K(+) at sites I and II, is suggested.

  14. LEITURA E LEITURA NA UNIVERSIDADE

    Directory of Open Access Journals (Sweden)

    Profª Drª Márcia A. G. Molina

    2015-12-01

    Full Text Available O texto apresenta uma discussão acerca da leitura, traçando, primeiramente, um percurso histórico dessa questão, iniciando-se no XIX aqui no Brasil.. Na sequência, aponta-se para a importância daquele que trabalha com a leitura ter paixão por ela, para que possa formar sujeitos também apaixonados pelo ato de ler. Continua mostrando os tipos de leitura, de acordo com FREIRE (1989, KOCK e ELIAS (2006 e apontando as atuais orientações para os procedimentos de leitura de um texto, baseados em KLEIMAN (2002. Conclui-se que, para formar o bom leitor, entendido como aquele que lê o não-dito e caminha para além da paráfrase reprodutiva, deve-se: ter paixão pela leitura, orientar os estudantes para essa prática, estabelecendo-se objetivos de leitura e reconhecer as estratégias que compreendem essa atividade.

  15. Necessidades da vida na morte

    Directory of Open Access Journals (Sweden)

    Denise Stefanoni Combinato

    2017-04-01

    Full Text Available Em função do envelhecimento populacional e aumento de doenças crônicas não transmissíveis, a Estratégia Saúde da Família (ESF tem se deparado com as necessidades das pessoas em processo de morte. A partir da análise do trabalho de profissionais da saúde que cuidaram de pessoas em processo de morte, o objetivo deste artigo é discutir as necessidades de saúde nesse processo, a fim de subsidiar o trabalho com essa população, especialmente na Atenção Primária à Saúde. Participaram da entrevista, após serem selecionados por dois questionários, onze profissionais (enfermeiros e médicos da ESF de Campinas/SP. A análise de dados foi pautada no referencial teórico-metodológico da Psicologia histórico-cultural. Como resultado, tem-se que as necessidades dos pacientes e familiares não são restritas ao momento de vida (proximidade da morte, mas referem-se, também, às condições de vulnerabilidade social.

  16. Terapia de linguagem na afasia

    Directory of Open Access Journals (Sweden)

    Mauro Spinelli

    1977-12-01

    Full Text Available A terapia da linguagem na afasia foi estudada em 15 pacientes, 8 do sexo masculino e 7 do sexo feminino; a idade variou de menos de 10 anos a mais de 50 anos; em 11 casos a afasia era sequela de acidente vascular cerebral e, em 4, de traumatismo crânio-encefálico. Quanto ao tipo de afasia, 5 pacientes apresentavam déficits predominantemente de expressão e 10 apresentavam déficits receptivos e expressivos em graus equiparáveis. Em 6 casos a terapia foi iniciada dentro dos 3 primeiros meses de instalação do quadro; nos restantes foi iniciada mais tardiamente. Dos 15 pacientes, 11 apresentaram evolução satisfatória, a qual não depndeu do grau de afasia, do tipo de afasia, da idade do paciente, do tipo de patologia e do intervalo entre a instalação do quadro afásico e o início da terapia. A terapia da linguagem no paciente afásico é efetiva, o prognóstico não pode ser feito a priori. Somente a evolução do caso com sua retestagem criteriosa poderá dar dados realmente úteis para se falar em evolução.

  17. Liquido cefalorraquiano na cisticercose encefalica

    Directory of Open Access Journals (Sweden)

    João Baptista dos Reis

    1979-06-01

    Full Text Available Foi feito um estudo do comportamento do líquido cefalorraquiano (LCR na cisticercose encefálica, com base em 656 observações retiradas de um material constituído por 120.000 exames de pacientes neurológicos e psiquiátricos, reunidas em 35 anos de trabalho. Com base nos casos comprovados por necrópsia ou cirurgia foram descritas as alterações do LCR. O estudo consecutivo de amostras de LCR obtidas em anos sucessivos, durante o decurso da doença, mostrou a persistência das alterações em numerosos casos, mesmo depois de 4 a 18 anos de observação. A reação de fixação de complemento para cisticerco permaneceu positiva durante todos estes anos. Foram também apreciadas as modificações do LCR em casos de cisticercose sub-cutânea e do globo ocular e em casos com cisticercos calcificados no encéfalo.

  18. Barroco: A tempestade na Biblioteca

    Directory of Open Access Journals (Sweden)

    Diego Cervelin

    2008-10-01

    Full Text Available http://dx.doi.org/10.5007/1984-784x.2008v8n12p167 Desde que Heinrich Wölfflin, nos últimos vinte anos do século XIX, se interessou por trazer à tona as formas arquitetônicas do século XVII conferindo-lhes caráter autônomo de estilo histórico determinável, não é nenhuma novidade que os estudos sobre o barroco pudessem polarizar – quase sempre em um tom colérico – os pesquisadores da arte e da cultura. Em terras do Brasil, não chega a ser de todo descabido recordar a severíssima crítica operada por Sérgio Buarque de Holanda em Raízes do Brasil. O livro, que pretende detectar a avalanche de equívocos que teria povoado o passado nacional com as vistas voltadas para a concretização de um projeto de emancipação e progresso na linha da história brasileira, apresenta em seu quarto capítulo uma impugnação explícita ao passado colonial.

  19. Barroco: A tempestade na Biblioteca

    Directory of Open Access Journals (Sweden)

    Diego Cervelin

    2008-12-01

    Full Text Available Desde que Heinrich Wölfflin, nos últimos vinte anos do século XIX, se interessou por trazer à tona as formas arquitetônicas do século XVII conferindo-lhes caráter autônomo de estilo histórico determinável, não é nenhuma novidade que os estudos sobre o barroco pudessem polarizar – quase sempre em um tom colérico – os pesquisadores da arte e da cultura. Em terras do Brasil, não chega a ser de todo descabido recordar a severíssima crítica operada por Sérgio Buarque de Holanda em Raízes do Brasil. O livro, que pretende detectar a avalanche de equívocos que teria povoado o passado nacional com as vistas voltadas para a concretização de um projeto de emancipação e progresso na linha da história brasileira, apresenta em seu quarto capítulo uma impugnação explícita ao passado colonial.

  20. Gasotransmitters: Novel regulators of epithelial Na+ transport?

    Directory of Open Access Journals (Sweden)

    Mike eAlthaus

    2012-04-01

    Full Text Available The vectorial transport of Na+ across epithelia is crucial for the maintenance of Na+ and water homeostasis in organs such as the kidneys, lung or intestine. Dysregulated Na+ transport processes are associated with various human diseases such as hypertension, the salt-wasting syndrome pseudohypoaldosteronism type 1, pulmonary edema, cystic fibrosis or intestinal disorders, which indicate that a precise regulation of epithelial Na+ transport is essential. Novel regulatory signaling molecules are gasotransmitters. There are currently three known gasotransmitters: nitric oxide (NO, carbon monoxide (CO and hydrogen sulfide (H2S. These molecules are endogenously produced in mammalian cells by specific enzymes and have been shown to regulate various physiological processes. There is a growing body of evidence, which indicates that gasotransmitters may also regulate Na+ transport across epithelia. This review will summarize the available data concerning NO, CO and H2S dependent regulation of epithelial Na+ transport processes and will discuss whether or not these mediators can be considered as true physiological regulators of epithelial Na+ transport biology.

  1. NMR studies on Na+ transport in Synechococcus PCC 6311

    Science.gov (United States)

    Nitschmann, W. H.; Packer, L.

    1992-01-01

    The freshwater cyanobacterium Synechococcus PCC 6311 is able to adapt to grow after sudden exposure to salt (NaCl) stress. We have investigated the mechanism of Na+ transport in these cells during adaptation to high salinity. Na+ influx under dark aerobic conditions occurred independently of delta pH or delta psi across the cytoplasmic membrane, ATPase activity, and respiratory electron transport. These findings are consistent with the existence of Na+/monovalent anion cotransport or simultaneous Na+/H+ +anion/OH- exchange. Na+ influx was dependent on Cl-, Br-, NO3-, or NO2-. No Na+ uptake occurred after addition of NaI, NaHCO3, or Na2SO4. Na+ extrusion was absolutely dependent on delta pH and on an ATPase activity and/or on respiratory electron transport. This indicates that Na+ extrusion via Na+/H+ exchange is driven by primary H+ pumps in the cytoplasmic membrane. Cells grown for 4 days in 0.5 m NaCl medium, "salt-grown cells," differ from control cells by a lower maximum velocity of Na+ influx and by lower steady-state ratios of [Na+]in/[Na+]out. These results indicate that cells grown in high-salt medium increase their capacity to extrude Na+. During salt adaptation Na+ extrusion driven by respiratory electron transport increased from about 15 to 50%.

  2. Na/K pump inactivation, subsarcolemmal Na measurements, and cytoplasmic ion turnover kinetics contradict restricted Na spaces in murine cardiac myocytes

    OpenAIRE

    Lu, Fang-Min; Hilgemann, Donald W.

    2017-01-01

    The Na/K pump exports cytoplasmic Na ions while importing K ions, and its activity is thought to be affected by restricted intracellular Na diffusion in cardiac myocytes. Lu and Hilgemann find instead that the pump can enter an inactivated state and that inactivation can be relieved by cytoplasmic Na.

  3. Fotokromne tiskarske barve na osnovi resorufina

    OpenAIRE

    Drnovšek, Petra

    2017-01-01

    Pametni materiali pod vplivom zunanjega dejavnika na predvidljiv in navadno uporaben način spremenijo svoje lastnosti. Takšni materiali so fotokatalitsko aktivne tiskarske barve, pri katerih se pod vplivom ultravijoličnega sevanja (v nadaljevanju UV) in/ali vidne svetlobe sproži fotokataliza, čemur sledi sprememba barve. Ena izmed možnih aplikacij fotokatalitsko aktivnih tiskarskih barv je ta, da uporabnika s spremembo barve opozarjajo na količino izpostavljenosti potencialno škodljivemu UV s...

  4. Pretpostavke za valorizaciju zapisa na elektronskim medijima

    OpenAIRE

    Eržišnik, Davorin

    1999-01-01

    U napisu se raspravlja o razlozima za valorizaciju zapisa na elektronskim medijima. Oni su ujedno i pretpostavke za tu valorizaciju, jer da bi ona uoće provodila, moraju postojati i razlozi. Istraživanje se bazira na usporedbi izmedju tih zapisa s jedne strane te klasičnih dokumenata i mikrofilmskih zapisa, s druge. Zaključuje se da u odnosu na tu drugu stranu, elektronski zapisi moraju imati i neke dodatne prednosti i kvalitete. U protivnom, ni ta valorizacija ne bi imala smisla.

  5. Naša eko hrana

    OpenAIRE

    Kelnerić, Tatjana

    2013-01-01

    Zdrav način življenja trajna je zadaća održivog razvoja i može se reći da ne postoji dobna granica za početak takvog načina života. U tom kontekstu neizbježno je da cilj svakog odgojno-obrazovnog rada, bilo da je riječ o projektu ili svakodnevici jedne odgojno-obrazovne skupine u dječjem vrtiću, mora biti usmjeren na čisto i zdravo okruženje, neposredan kontakt djeteta s prirodom, pravilnu prehranu i kretanje.

  6. VPLIV TEHNOLOŠKIH SPREMEMB NA GLOBALIZACIJO

    OpenAIRE

    Mohar, Nives

    2015-01-01

    Magistrsko delo z naslovom »Vpliv tehnoloških dejavnikov na globalizacijo« zajema dve večji področji ekonomske teorije – tehnologijo in globalizacijo. Namen magistrskega dela je analizirati odnose med tehnološkimi spremembami, gospodarsko rastjo in globaliziranostjo držav. Teoretični del smo razdelili na obravnavo tehnologije in globalizacije. Najprej smo predstavili pojme, ki se navezujejo na tehnologijo, nato smo prikazali mesto tehnologije skozi zgodovino ekonomske teorije in predstavi...

  7. Na+,K+ pumpen vedbliver at overraske

    DEFF Research Database (Denmark)

    Vilsen, Bente

    2008-01-01

    This article provides an overview of news about the Na+,K+ pump, an indispensable enzyme whose protein structure has been described in a recent article in Nature, 50 years after its discovery. In combination with mutational analysis, the structure reveals the binding pocket for the K+ ions...... and the regulation of Na+ transport by a strategically located C-terminus of the protein. Focus is also on the pathophysiology of two neurological disorders, familial hemiplegic migraine and rapid-onset dystonia-parkinsonism, recently shown to be caused by mutations in the Na+,K+-ATPase. Udgivelsesdato: may 19...

  8. Myocardial Na,K-ATPase: Clinical aspects

    Science.gov (United States)

    Kjeldsen, Keld

    2003-01-01

    The specific binding of digitalis glycosides to Na,K-ATPase is used as a tool for Na,K-ATPase quantification with high accuracy and precision. In myocardial biopsies from patients with heart failure, total Na,K-ATPase concentration is decreased by around 40%; a correlation exists between a decrease in heart function and a decrease in Na,K-ATPase concentration. During digitalization, around 30% of remaining pumps are occupied by digoxin. Myocardial Na,K-ATPase is also influenced by other drugs used for the treatment of heart failure. Thus, potassium loss during diuretic therapy has been found to reduce myocardial Na,K-ATPase, whereas angiotensin-converting enzyme inhibitors may stimulate Na,K pump activity. Furthermore, hyperaldosteronism induced by heart failure has been found to decrease Na,K-ATPase activity. Accordingly, treatment with the aldosterone antagonist, spironolactone, may also influence Na,K-ATPase activity. The importance of Na,K pump modulation with heart disease, inhibition in digitalization and other effects of medication should be considered in the context of sodium, potassium and calcium regulation. It is recommended that digoxin be administered to heart failure patients who, after institution of mortality-reducing therapy, still have heart failure symptoms, and that the therapy be continued if symptoms are revealed or reduced. Digitalis glycosides are the only safe inotropic drugs for oral use that improve hemodynamics in heart failure. An important aspect of myocardial Na,K pump affection in heart disease is its influence on extracellular potassium (Ke) homeostasis. Two important aspects should be considered: potassium handling among myocytes, and effects of potassium entering the extracellular space of the heart via the bloodstream. It should be noted that both of these aspects of Ke homeostasis are affected by regulatory aspects, eg, regulation of the Na,K pump by physiological and pathophysiological conditions, as well as by medical

  9. Prepoznavanje spolnega nadlegovanja na delovnem mestu v zdravstvu

    OpenAIRE

    Lešnik, Tina

    2013-01-01

    Diplomsko delo predstavlja problem spolnega nadlegovanja na delovnem mestu na podlagi slovenske in tuje teorije ter se osredotoča na ugotavljanje pojava spolnega nadlegovanja na delovnem mestu v zdravstvu. Izhodišča: Dosedanje raziskave nasilja in spolnega nadlegovanja na delovnem mestu kažejo, da so zdravstveni delavci le temu izpostavljeni bolj kot delavci v drugih panogah. V okviru diplomskega dela smo raziskali prepoznavanje in pojavnost spolnega nadlegovanja na delovnem mestu med štu...

  10. Glutathionylation-Dependence of Na+-K+-Pump Currents Can Mimic Reduced Subsarcolemmal Na+ Diffusion

    Science.gov (United States)

    Garcia, Alvaro; Liu, Chia-Chi; Cornelius, Flemming; Clarke, Ronald J.; Rasmussen, Helge H.

    2016-01-01

    The existence of a subsarcolemmal space with restricted diffusion for Na+ in cardiac myocytes has been inferred from a transient peak electrogenic Na+-K+ pump current beyond steady state on reexposure of myocytes to K+ after a period of exposure to K+-free extracellular solution. The transient peak current is attributed to enhanced electrogenic pumping of Na+ that accumulated in the diffusion-restricted space during pump inhibition in K+-free extracellular solution. However, there are no known physical barriers that account for such restricted Na+ diffusion, and we examined if changes of activity of the Na+-K+ pump itself cause the transient peak current. Reexposure to K+ reproduced a transient current beyond steady state in voltage-clamped ventricular myocytes as reported by others. Persistence of it when the Na+ concentration in patch pipette solutions perfusing the intracellular compartment was high and elimination of it with K+-free pipette solution could not be reconciled with restricted subsarcolemmal Na+ diffusion. The pattern of the transient current early after pump activation was dependent on transmembrane Na+- and K+ concentration gradients suggesting the currents were related to the conformational poise imposed on the pump. We examined if the currents might be accounted for by changes in glutathionylation of the β1 Na+-K+ pump subunit, a reversible oxidative modification that inhibits the pump. Susceptibility of the β1 subunit to glutathionylation depends on the conformational poise of the Na+-K+ pump, and glutathionylation with the pump stabilized in conformations equivalent to those expected to be imposed on voltage-clamped myocytes supported this hypothesis. So did elimination of the transient K+-induced peak Na+-K+ pump current when we included glutaredoxin 1 in patch pipette solutions to reverse glutathionylation. We conclude that transient K+-induced peak Na+-K+ pump current reflects the effect of conformation-dependent β1 pump subunit

  11. Altered Na+ transport after an intracellular alpha-subunit deletion reveals strict external sequential release of Na+ from the Na/K pump.

    Science.gov (United States)

    Yaragatupalli, Siddhartha; Olivera, J Fernando; Gatto, Craig; Artigas, Pablo

    2009-09-08

    The Na/K pump actively exports 3 Na(+) in exchange for 2 K(+) across the plasmalemma of animal cells. As in other P-type ATPases, pump function is more effective when the relative affinity for transported ions is altered as the ion binding sites alternate between opposite sides of the membrane. Deletion of the five C-terminal residues from the alpha-subunit diminishes internal Na(+) (Na(i)(+)) affinity approximately 25-fold [Morth et al. (2007) Nature 450:1043-1049]. Because external Na(+) (Na(o)(+)) binding is voltage-dependent, we studied the reactions involving this process by using two-electrode and inside-out patch voltage clamp in normal and truncated (DeltaKESYY) Xenopus-alpha1 pumps expressed in oocytes. We observed that DeltaKESYY (i) decreased both Na(o)(+) and Na(i)(+) apparent affinities in the absence of K(o)(+), and (ii) did not affect apparent Na(o)(+) affinity at high K(o)(+). These results support a model of strict sequential external release of Na(+) ions, where the Na(+)-exclusive site releases Na(+) before the sites shared with K(+) and the DeltaKESYY deletion only reduces Na(o)(+) affinity at the shared sites. Moreover, at nonsaturating K(o)(+), DeltaKESYY induced an inward flow of Na(+) through Na/K pumps at negative potentials. Guanidinium(+) can also permeate truncated pumps, whereas N-methyl-D-glucamine cannot. Because guanidinium(o)(+) can also traverse normal Na/K pumps in the absence of both Na(o)(+) and K(o)(+) and can also inhibit Na/K pump currents in a Na(+)-like voltage-dependent manner, we conclude that the normal pathway transited by the first externally released Na(+) is large enough to accommodate guanidinium(+).

  12. Painful Na-channelopathies: an expanding universe.

    Science.gov (United States)

    Waxman, Stephen G

    2013-07-01

    The universe of painful Na-channelopathies--human disorders caused by mutations in voltage-gated sodium channels--has recently expanded in three dimensions. We now know that mutations of sodium channels cause not only rare genetic 'model disorders' such as inherited erythromelalgia and channelopathy-associated insensitivity to pain but also common painful neuropathies. We have learned that mutations of NaV1.8, as well as mutations of NaV1.7, can cause painful Na-channelopathies. Moreover, recent studies combining atomic level structural models and pharmacogenomics suggest that the goal of genomically guided pain therapy may not be unrealistic. Copyright © 2013 Elsevier Ltd. All rights reserved.

  13. Erythrocyte 22Na+ influx in hypertension

    International Nuclear Information System (INIS)

    Shalev, O.; Eaton, J.W.; Ben-Ishay, D.

    1984-01-01

    We assessed 22Na+ uptake by erythrocytes (RBC) from 38 individuals with essential hypertension and 37 healthy controls. All subjects were male, white, non-obese and with normal renal function, obviating sex, race, hormonal, ponderal and renal factors known to influence RBC Na+ handling. The mean +/- sem 22Na+ uptake of the patients was 284 +/- 16 mumole/liter RBC/hour while that of normal controls was 249 +/- 11 mumole/liter RBC/hour; although the difference reached borderline significance, individual values showed considerable overlap. Consequently, in our population, RBC 22Na+ uptake is not a reliable marker for essential hypertension. We believe that previous studies should be reassessed with regard to patients' characteristics and future studies employ rigorous criteria in selection of subjects

  14. Protective effect of a phenolic extract containing indoline amides from Portulaca oleracea against cognitive impairment in senescent mice induced by large dose of D-galactose /NaNO2.

    Science.gov (United States)

    Wang, Peipei; Sun, Hongxiang; Liu, Dianyu; Jiao, Zezhao; Yue, Su; He, Xiuquan; Xia, Wen; Ji, Jianbo; Xiang, Lan

    2017-05-05

    brain AChE activity. PAAs as the bioactive principles of P. oleracea attenuated oxidative stress, improved survival rate, and enhanced cognitive function in D-gal/NaNO 2 -induced senile mice, similar to piracetam. This phenolic extract provides a promising candidate for prevention of aging and aging-related cognitive dysfunction in clinic. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

  15. Na+-H+ exchange and Na+-dependent transport systems in streptozotocin diabetic rat kidneys

    International Nuclear Information System (INIS)

    El-Seifi, S.; Freiberg, J.M.; Kinsella, F.J.; Cheng, L.; Sacktor, B.

    1987-01-01

    The streptozotocin-induced diabetic rat was used to test the hypothesis that Na + -H + exchange activity in the proximal tubule luminal membrane would be increased in association with renal hypertrophy, altered glomerular hemodynamics, enhanced filtered load and tubular reabsorption of 22 Na + , and stimulated 22 Na= pump activity in the basolateral membrane, previously reported characteristics of this experimental animal model. Amiloride-sensitive H + gradient-dependent Na + uptake and Na + gradient-dependent H + flux were increased in brush-border membrane vesicles from the streptozotocin-treated animals. Na + gradient-dependent uptakes of phosphate, D-glucose, L-proline, and myoinositol were decreased in the drug-induced diabetic animals. These membrane transport alterations were not found when the streptozotocin-diabetic animals were treated with insulin

  16. Perfil nutricional na artrite reumatoide

    Directory of Open Access Journals (Sweden)

    Rachel Simone Maccarini Zarpellon

    2014-01-01

    Full Text Available Objetivo: Estudar o perfil nutricional de pacientes com artrite reumatoide (AR. Métodos: Estudo transversal observacional de 102 pacientes com AR. Os pacientes foram estudados para dados clínicos, demográficos, sorológicos, atividade de doença e perfil nutricional. Neste último incluiu-se a medida do índice de massa corporal (IMC, relação quadril/cintura, pregas cutâneas bicipitais (PCB e sua adequação; prega cutânea tricipital (PCT e sua adequação e circunferência muscular do braço (CMB e sua adequação. Estudos de associação foram feitos usando os testes de Fisher e qui-quadrado para dados nominais e teste t não pareado e Mann Whitney para dados numéricos. Para cálculo de correlação usou-se o teste de Spearman. Resultado: Na amostra existiam 14/102 homens e 88/102 mulheres com idade média de 52,1 ± 11,5 anos e duração média de doença de 10,6 ± 7,4 anos. A relação cintura/quadril média era de 0,92 ± 0,07. De acordo com IMC, 30,3% tinham peso normal e 65,5% tinham peso acima do normal. De acordo com PCB, 74,5% eram normais e 25,5% tinham depleção; de acordo com a PCT, 83,3% eram normais e 16,7% tinham depleção. Associação de variáveis nutricionais com gênero, fator reumatoide, nódulos e atividade da doença não mostraram diferenças (p = NS exceto, por uma relação cintura/quadril menor em indivíduos com nódulos (p = 0,02 e uma correlação modesta da PCT com a duração de doença (p = 0,02; R = 0,22; 95% IC = 0,01-0,40. Conclusão: Existe uma alta prevalência de sobrepeso e obesidade em artrite reumatoide e uma pequena frequência de depleção muscular.

  17. Glutathionylation-Dependence of Na+-K+-Pump Currents Can Mimic Reduced Subsarcolemmal Na+ Diffusion

    OpenAIRE

    Garcia, Alvaro; Liu, Chia-Chi; Cornelius, Flemming; Clarke, Ronald?J.; Rasmussen, Helge?H.

    2016-01-01

    The existence of a subsarcolemmal space with restricted diffusion for Na+ in cardiac myocytes has been inferred from a transient peak electrogenic Na+-K+ pump current beyond steady state on reexposure of myocytes to K+ after a period of exposure to K+-free extracellular solution. The transient peak current is attributed to enhanced electrogenic pumping of Na+ that accumulated in the diffusion-restricted space during pump inhibition in K+-free extracellular solution. However, there are no know...

  18. Theoretical study of Na(4p2P)+Na(3s2S) and Cd(5p3P0)+Na(3s2S) collisions and their role in the energy transfer between Cd* and Na

    International Nuclear Information System (INIS)

    Magnier, S.; Pisa Univ.; Angeli, C.; Granucci, G.; Masnou-Seeuws, F.; Allegrini, M.; Pisa Univ.; Persico, M.

    1997-01-01

    We have computed the cross sections for the energy transfer process Cd(5p 3 P 0 ) + Na(3s 2 S) →Cd(5s 1 S) + Na(4p 2 P) and for the state changing collision Na(4p 2 P) + Na(3s 2 S)→Na(3d 2 D) + Na(3s 2 S), based on theoretical interaction potentials for the NaCd and Na 2 systems, respectively. Our calculations shed light on the interpretation of experiments with laser excited Na+Cd vapour mixtures. It turns out that Cd(5p 3 P 0 ), in rapid equilibrium with the doorway state Cd(5p 3 P 1 ), efficiently transfers energy to Na, populating the 4p 2 P state. The collisions with ground state Na cause a very fast conversion of the 4p 2 P to the 3d 2 D state, from which the strongest emission is observed. (orig.)

  19. Suppression of Na interstitials in Na-F codoped ZnO

    Science.gov (United States)

    Huo, Wenxing; Mei, Zengxia; Tang, Aihua; Liang, Huili; Du, Xiaolong

    2018-04-01

    Controlling the formation of interstitial Na (Nai) self-compensating defects has been a long-term physics problem for effective Na doping in ZnO. Herein, we present an experimental approach to the suppression of Nai defects in ZnO via Na and F codoping under an oxygen-rich condition during the molecular beam epitaxy growth process. It is found that the incorporation of such large numbers of Na and F dopants (˜1020 cm-3) does not cause an obvious influence on the lattice parameters. Hall-effect measurements demonstrate that F doping efficiently raises the Fermi level (EF) of ZnO films, which is expected to make the formation energy of Nai and NaZn increase and decrease, respectively. Most of the Na atoms occupy the substitutional Zn sites, and the formation of Nai is suppressed consequently. Secondary ion mass spectrometry measurements reveal that F and Na atoms are tightly bonded together due to their strong Coulomb interaction. The enhanced deep level emission (DLE) in ZnO:Na-F is ascribed to the considerable amount of isolated Zn vacancy (VZn) defects induced by the elevated EF and the formation of neutral (" separators="| FO + - Na Zn - ) 0 complexes. On the other hand, formation of (" separators="| FO + - VZn 2 - ) - complexes in ZnO:F exhausts most of the isolated Zn vacancies, leading to the disappearance of the DLE band.

  20. Absolute quantification of Na + bound fraction by double-quantum filtered 23Na NMR spectroscopy

    Science.gov (United States)

    Mouaddab, Mohamed; Foucat, Loïc; Donnat, Jean Pierre; Renou, Jean Pierre; Bonny, Jean Marie

    2007-11-01

    A method is described for the absolute quantification of double-quantum filtered spectra of spin-3/2 nuclei ( 23Na). The method was tested on a model system, a cationic exchange resin for which the number of Na + binding sites was quantitatively controlled. The theoretical and experimental approaches were validated on samples with different Na + concentrations. An excellent agreement between the results obtained by double-quantum and single-quantum acquisitions was found. This method paves the way for absolute quantification of both bound and free fractions of Na +, which are determining factors in the characterization of salted/brined/dried food products.

  1. Interaction between Na+/K+-pump and Na+/Ca2+-exchanger modulates intercellular communication.

    Science.gov (United States)

    Matchkov, Vladimir V; Gustafsson, Helena; Rahman, Awahan; Briggs Boedtkjer, Donna M; Gorintin, Sarah; Hansen, Anne Kirstine; Bouzinova, Elena V; Praetorius, Helle A; Aalkjaer, Christian; Nilsson, Holger

    2007-04-13

    Ouabain, a specific inhibitor of the Na(+)/K(+)-pump, has previously been shown to interfere with intercellular communication. Here we test the hypothesis that the communication between vascular smooth muscle cells is regulated through an interaction between the Na(+)/K(+)-pump and the Na(+)/Ca(2+)-exchanger leading to an increase in the intracellular calcium concentration ([Ca(2+)](i)) in discrete areas near the plasma membrane. [Ca(2+)](i) in smooth muscle cells was imaged in cultured rat aortic smooth muscle cell pairs (A7r5) and in rat mesenteric small artery segments simultaneously with force. In A7r5 coupling between cells was estimated by measuring membrane capacitance. Smooth muscle cells were uncoupled when the Na(+)/K(+)-pump was inhibited either by a low concentration of ouabain, which also caused a localized increase of [Ca(2+)](i) near the membrane, or by ATP depletion. Reduction of Na(+)/K(+)-pump activity by removal of extracellular potassium ([K(+)](o)) also uncoupled cells, but only after inhibition of K(ATP) channels. Inhibition of the Na(+)/Ca(2+)-exchange activity by SEA0400 or by a reduction of the equilibrium potential (making it more negative) also uncoupled the cells. Depletion of intracellular Na(+) and clamping of [Ca(2+)](i) at low concentrations prevented the uncoupling. The experiments suggest that the Na(+)/K(+)-pump may affect gap junction conductivity via localized changes in [Ca(2+)](i) through modulation of Na(+)/Ca(2+)-exchanger activity.

  2. HCO3(-)-coupled Na+ influx is a major determinant of Na+ turnover and Na+/K+ pump activity in rat hepatocytes

    International Nuclear Information System (INIS)

    Fitz, J.G.; Lidofsky, S.D.; Weisiger, R.A.; Xie, M.H.; Cochran, M.; Grotmol, T.; Scharschmidt, B.F.

    1991-01-01

    Recent studies in hepatocytes indicate that Na(+)-coupled HCO3- transport contributes importantly to regulation of intracellular pH and membrane HCO3- transport. However, the direction of net coupled Na+ and HCO3- movement and the effect of HCO3- on Na+ turnover and Na+/K+ pump activity are not known. In these studies, the effect of HCO3- on Na+ influx and turnover were measured in primary rat hepatocyte cultures with 22Na+, and [Na+]i was measured in single hepatocytes using the Na(+)-sensitive fluorochrome SBFI. Na+/K+ pump activity was measured in intact perfused rat liver and hepatocyte monolayers as Na(+)-dependent or ouabain-suppressible 86Rb uptake, and was measured in single hepatocytes as the effect of transient pump inhibition by removal of extracellular K+ on membrane potential difference (PD) and [Na+]i. In hepatocyte monolayers, HCO3- increased 22Na+ entry and turnover rates by 50-65%, without measurably altering 22Na+ pool size or cell volume, and HCO3- also increased Na+/K+ pump activity by 70%. In single cells, exposure to HCO3- produced an abrupt and sustained rise in [Na+]i from approximately 8 to 12 mM. Na+/K+ pump activity assessed in single cells by PD excursions during transient K+ removal increased congruent to 2.5-fold in the presence of HCO3-, and the rise in [Na+]i produced by inhibition of the Na+/K+ pump was similarly increased congruent to 2.5-fold in the presence of HCO3-. In intact perfused rat liver, HCO3- increased both Na+/K+ pump activity and O2 consumption. These findings indicate that, in hepatocytes, net coupled Na+ and HCO3- movement is inward and represents a major determinant of Na+ influx and Na+/K+ pump activity. About half of hepatic Na+/K+ pump activity appears dedicated to recycling Na+ entering in conjunction with HCO3- to maintain [Na+]i within the physiologic range

  3. Clues to NaCN formation

    Science.gov (United States)

    Quintana-Lacaci, G.; Cernicharo, J.; Velilla Prieto, L.; Agúndez, M.; Castro-Carrizo, A.; Fonfría, J. P.; Massalkhi, S.; Pardo, J. R.

    2017-11-01

    Context. ALMA is providing us essential information on where certain molecules form. Observing where these molecules emission arises from, the physical conditions of the gas, and how this relates with the presence of other species allows us to understand the formation of many species, and to significantly improve our knowledge of the chemistry that occurs in the space. Aims: We studied the molecular distribution of NaCN around IRC +10216, a molecule detected previously, but whose origin is not clear. High angular resolution maps allow us to model the abundance distribution of this molecule and check suggested formation paths. Methods: We modeled the emission of NaCN assuming local thermal equilibrium (LTE) conditions. These profiles were fitted to azimuthal averaged intensity profiles to obtain an abundance distribution of NaCN. Results: We found that the presence of NaCN seems compatible with the presence of CN, probably as a result of the photodissociation of HCN, in the inner layers of the ejecta of IRC +10216. However, similar as for CH3CN, current photochemical models fail to reproduce this CN reservoir. We also found that the abundance peak of NaCN appears at a radius of 3 × 1015 cm, approximately where the abundance of NaCl, suggested to be the parent species, starts to decay. However, the abundance ratio shows that the NaCl abundance is lower than that obtained for NaCN. We expect that the LTE assumption might result in NaCN abundances higher than the real ones. Updated photochemical models, collisional rates, and reaction rates are essential to determine the possible paths of the NaCN formation. Based on observations carried out with ALMA and the IRAM 30 m Telescope. ALMA is a partnership of ESO (representing its member states), NSF (USA) and NINS (Japan), together with NRC (Canada) and NSC and ASIAA (Taiwan), in cooperation with the Republic of Chile. The Joint ALMA Observatory is operated by ESO, AUI/NRAO and NAOJ. IRAM is supported by INSU/CNRS (France

  4. Quasi–solid state rechargeable Na-CO2 batteries with reduced graphene oxide Na anodes

    Science.gov (United States)

    Hu, Xiaofei; Li, Zifan; Zhao, Yaran; Sun, Jianchao; Zhao, Qing; Wang, Jianbin; Tao, Zhanliang; Chen, Jun

    2017-01-01

    Na-CO2 batteries using earth-abundant Na and greenhouse gas CO2 are promising tools for mobile and stationary energy storage, but they still pose safety risks from leakage of liquid electrolyte and instability of the Na metal anode. These issues result in extremely harsh operating conditions of Na-CO2 batteries and increase the difficulty of scaling up this technology. We report the development of quasi–solid state Na-CO2 batteries with high safety using composite polymer electrolyte (CPE) and reduced graphene oxide (rGO) Na anodes. The CPE of PVDF-HFP [poly(vinylidene fluoride-co-hexafluoropropylene)]–4% SiO2/NaClO4–TEGDME (tetraethylene glycol dimethyl ether) has high ion conductivity (1.0 mS cm−1), robust toughness, a nonflammable matrix, and strong electrolyte-locking ability. In addition, the rGO-Na anode presents fast and nondendritic Na+ plating/stripping (5.7 to 16.5 mA cm−2). The improved kinetics and safety enable the constructed rGO-Na/CPE/CO2 batteries to successfully cycle in wide CO2 partial pressure window (5 to 100%, simulated car exhaust) and especially to run for 400 cycles at 500 mA g−1 with a fixed capacity of 1000 mA·hour g−1 in pure CO2. Furthermore, we scaled up the reversible capacity to 1.1 A·hour in pouch-type batteries (20 × 20 cm, 10 g, 232 Wh kg−1). This study makes quasi–solid state Na-CO2 batteries an attractive prospect. PMID:28164158

  5. Kupokelewa Zaidi Kwa Simu Ya Mkononi Kuliko Kompyuta Na ...

    African Journals Online (AJOL)

    Mtandao wa tovuti ni nyenzo ya msingi katika maendeleo ya uwanja wa mawasiliano unaounganisha watu na jamii mbalimbali katika ulimwengu wa leo unaotandawaa. Katika “ulimwengu wa kwanza na wa pili”, yaani mabara ya Amerika, Uropa na Asia, maendeleo na mapinduzi makubwa katika uwanja wa teknolojia ya ...

  6. Effects of different NaCl Concentrations on germination and ...

    African Journals Online (AJOL)

    Growth was steadily stimulated in both species at lower NaCl levels with best growth stimulation at 50 mM NaCl but was adversely affected by higher NaCl concentration levels (75, 100 and 150 mM). Both species ... Key words: Germination, early seedling growth, NaCl, salinity, Amaranthus hybridus, Celosia argentea.

  7. Ujanibishaji wa Office 2003 na Windows XP kwa Kiswahili Sanifu ...

    African Journals Online (AJOL)

    Mradi wa ujanibishaji wa Office 2003 na Windows XP kwa Kiswahili sanifu ulitekelezwa katika kipindi 2004-2005. Malengo ya mradi yalikuwa: (1) kuandaa istilahi za kompyuta kwa Kiingereza-Kiswahili, na (2) kutafsiri programu nne za kawaida za Office (Outlook, Excel, Word na PowerPoint) na Windows XP. Makala hii ina ...

  8. Mabadiliko Ya Kifonolojia Na Kimofolojia Wakati Wa Utohozi Wa ...

    African Journals Online (AJOL)

    Mwingiliano wa lugha ya Kiswahili na Kiarabu una historia ndefu kidogo. Inasemekana Waarabu walianza muwasala na 'Waswahili' tangu karne ya kwanza (BK) (Polome 1967:9). Kutokana na muwasala huo wa muda mrefu, lugha hizi mbili (Kiarabu na Kiswahili) zimeathiriana sana. Lakini kuna maoni kwamba Kiarabu ...

  9. Utata kuhusu Dhana na Chimbuko la Wahadimu katika Kisiwa cha ...

    African Journals Online (AJOL)

    Data za makala haya zimepatikana kupitia usaili na majadiliano ya majopo ya wazungumzaji wa Kimakunduchi na Unguja na kujadili kwa muhtasari chimbuko la Wahadimu. Kwa muda mrefu dhana ya Wahadimu imekuwa ikijadiliwa kwa mitazamo tofautitofauti kama inavyobainishwa na wataalamu mbalimbali wakiwemo ...

  10. O Passeio Público do Rio de Janeiro na Literatura, na Pintura e na Fotografia do Século XIX

    Directory of Open Access Journals (Sweden)

    Solange de Aragão

    2012-06-01

    Full Text Available Este artigo tem como objetivo geral e mais amplo chamar a atenção dos pesquisadores para a importância da literatura, da pintura e da fotografia como fontes documentais para a construção da História do Paisagismo no Brasil por meio de um estudo de caso muito particular: o Passeio Público do Rio de Janeiro no século XIX. São objetivos específicos apresentar e analisar o modo como esse espaço livre público aparece na literatura, na pintura e na fotografia desse período, considerando suas transformações paisagísticas.

  11. Muziki wa Hip Hop na Haki Za Kijamii: Dhima, Changamoto na ...

    African Journals Online (AJOL)

    Ni dhahiri kuwa haki za kijamii zinaweza kuwasilishwa kwa jamii pana kupitia sanaa ya hip hop. Makala haya basi, yanabainisha dhima na mchango wa muziki wa hip hop katika masuala ya haki za kijamii, yanafafanua changamoto za muziki huu katika kuwasilisha haki za kijamii na kutoa mapendekezo kwa makundi ...

  12. Regeneration of plantlets under NaCl stress from NaN3 treated ...

    African Journals Online (AJOL)

    In this experiment, mutation induction in explants using NaN3 and subsequently, callus growth and plant regeneration under NaCl stressed conditions was assessed in some sugarcane (Saccharum officinarum L.) cultivars (Thatta-10, CPF-237 and SPHS-19). Immature bases of leaf tips were cultured on MS2n (MS salts, 3.0 ...

  13. Molecular dynamics investigation of Na+ in Na2Ni2TeO6

    International Nuclear Information System (INIS)

    Sau, Kartik; Kumar, P. Padma

    2014-01-01

    An inter-atomic potential for Na 2 Ni 2 TeO 6 in the Parrinello- Rahman-Vashishta (PRV) model is parameterized empirically. The potential reproduces variety of structural and transport properties of that material in good agreement with recent experimental results. The study provides fresh insights on the migration channels and mechanism of Na + in the system

  14. NaI(Tl) electron energy resolution

    CERN Document Server

    Mengesha, W

    2002-01-01

    NaI(Tl) electron energy resolution eta sub e was measured using the Modified Compton Coincidence Technique (MCCT). The MCCT allowed detection of nearly monoenergetic internal electrons resulting from the scattering of incident 662 keV gamma rays within a primary NaI(Tl) detector. Scattered gamma rays were detected using a secondary HPGe detector in a coincidence mode. Measurements were carried out for electron energies ranging from 16 to 438 keV, by varying the scattering angle. Measured HPGe coincidence spectra were deconvolved to determine the scattered energy spectra from the NaI(Tl) detector. Subsequently, the NaI(Tl) electron energy spectra were determined by subtracting the energy of scattered spectra from the incident source energy (662 keV). Using chi-squared minimization, iterative deconvolution of the internal electron energy spectra from the measured NaI(Tl) spectra was then used to determine eta sub e at the electron energy of interest. eta sub e values determined using this technique represent va...

  15. Na/K pump inactivation, subsarcolemmal Na measurements, and cytoplasmic ion turnover kinetics contradict restricted Na spaces in murine cardiac myocytes.

    Science.gov (United States)

    Lu, Fang-Min; Hilgemann, Donald W

    2017-07-03

    Decades ago, it was proposed that Na transport in cardiac myocytes is modulated by large changes in cytoplasmic Na concentration within restricted subsarcolemmal spaces. Here, we probe this hypothesis for Na/K pumps by generating constitutive transsarcolemmal Na flux with the Na channel opener veratridine in whole-cell patch-clamp recordings. Using 25 mM Na in the patch pipette, pump currents decay strongly during continuous activation by extracellular K (τ, ∼2 s). In contradiction to depletion hypotheses, the decay becomes stronger when pump currents are decreased by hyperpolarization. Na channel currents are nearly unchanged by pump activity in these conditions, and conversely, continuous Na currents up to 0.5 nA in magnitude have negligible effects on pump currents. These outcomes are even more pronounced using 50 mM Li as a cytoplasmic Na congener. Thus, the Na/K pump current decay reflects mostly an inactivation mechanism that immobilizes Na/K pump charge movements, not cytoplasmic Na depletion. When channel currents are increased beyond 1 nA, models with unrestricted subsarcolemmal diffusion accurately predict current decay (τ ∼15 s) and reversal potential shifts observed for Na, Li, and K currents through Na channels opened by veratridine, as well as for Na, K, Cs, Li, and Cl currents recorded in nystatin-permeabilized myocytes. Ion concentrations in the pipette tip (i.e., access conductance) track without appreciable delay the current changes caused by sarcolemmal ion flux. Importantly, cytoplasmic mixing volumes, calculated from current decay kinetics, increase and decrease as expected with osmolarity changes (τ >30 s). Na/K pump current run-down over 20 min reflects a failure of pumps to recover from inactivation. Simulations reveal that pump inactivation coupled with Na-activated recovery enhances the rapidity and effectivity of Na homeostasis in cardiac myocytes. In conclusion, an autoregulatory mechanism enhances cardiac Na/K pump activity when

  16. Anion-coupled Na efflux mediated by the human red blood cell Na/K pump

    International Nuclear Information System (INIS)

    Dissing, S.; Hoffman, J.F.

    1990-01-01

    The red cell Na/K pump is known to continue to extrude Na when both Na and K are removed from the external medium. Because this ouabain-sensitive flux occurs in the absence of an exchangeable cation, it is referred to as uncoupled Na efflux. This flux is also known to be inhibited by 5 mM Nao but to a lesser extent than that inhibitable by ouabain. Uncoupled Na efflux via the Na/K pump therefore can be divided into a Nao-sensitive and Nao-insensitive component. We used DIDS-treated, SO4-equilibrated human red blood cells suspended in HEPES-buffered (pHo 7.4) MgSO4 or (Tris)2SO4, in which we measured 22Na efflux, 35SO4 efflux, and changes in the membrane potential with the fluorescent dye, diS-C3 (5). A principal finding is that uncoupled Na efflux occurs electroneurally, in contrast to the pump's normal electrogenic operation when exchanging Nai for Ko. This electroneutral uncoupled efflux of Na was found to be balanced by an efflux of cellular anions. (We were unable to detect any ouabain-sensitive uptake of protons, measured in an unbuffered medium at pH 7.4 with a Radiometer pH-STAT.) The Nao-sensitive efflux of Nai was found to be 1.95 +/- 0.10 times the Nao-sensitive efflux of (SO4)i, indicating that the stoichiometry of this cotransport is two Na+ per SO4=, accounting for 60-80% of the electroneutral Na efflux. The remainder portion, that is, the ouabain-sensitive Nao-insensitive component, has been identified as PO4-coupled Na transport and is the subject of a separate paper. That uncoupled Na efflux occurs as a cotransport with anions is supported by the result, obtained with resealed ghosts, that when internal and external SO4 was substituted by the impermeant anion, tartrate i,o, the efflux of Na was inhibited 60-80%. This inhibition could be relieved by the inclusion, before DIDS treatment, of 5 mM Cli,o

  17. Metallic Na formation in NaCl crystals with irradiation of electron or vacuum ultraviolet photon

    Energy Technology Data Exchange (ETDEWEB)

    Owaki, Shigehiro [Osaka Prefecture Univ., Sakai, Osaka (Japan). Coll. of Integrated Arts and Sciences; Koyama, Shigeko; Takahashi, Masao; Kamada, Masao; Suzuki, Ryouichi

    1997-03-01

    Metallic Na was formed in NaCl single crystals with irradiation of a variety of radiation sources and analyzed the physical states with several methods. In the case of irradiation of 21 MeV electron pulses to the crystal blocks, the optical absorption and lifetime measurement of positron annihilation indicated appearance of Na clusters inside. Radiation effects of electron beam of 30 keV to the crystals in vacuum showed the appearance of not only metallic Na but atomic one during irradiation with Auger electron spectroscopy. Intense photon fluxes in vacuum ultraviolet region of synchrotron radiation were used as another source and an analyzing method of ultraviolet photoelectron spectroscopy. The results showed the metallic Na layered so thick that bulk plasmon can exist. (author)

  18. Hydrolysis of Rice Straw Pretreated by Na2SO3 Over Fe-resin/NaCl

    Directory of Open Access Journals (Sweden)

    YANG Hui

    2017-05-01

    Full Text Available To increase the conversion of rice straw(RS and the yield of products, we employed three methods, which were ultrasonic wave, steam explosion and Na2SO3 pretreatment to pretreat RS(the treated RS noted as CS-RS, ZQ-RS and Na2SO3-RS, respectively and found that Na2SO3 treatment was the best pretreatment method based on XRD, SEM, elemental analysis and content of cellulose, hemicellulose and lignin. The conversion of Na2SO3-RS and the yield of total reducing sugar(TRS and levulinic acid(LA were 97.3%, 29.6% and 13.5%, respectively by 10% Fe-resin in 3.3% NaCl solution under 200 ℃.

  19. Muscle K+, Na+, and Cl- disturbances and Na+-K+ pump inactivation: implications for fatigue

    DEFF Research Database (Denmark)

    McKenna, Michael J; Bangsbo, Jens; Renaud, Jean-Marc

    2008-01-01

    (+)-ATPase activity during exercise stabilizes Na(+) and K(+) concentration gradients and membrane excitability and thus protects against fatigue. However, during intense contraction some Na(+)-K(+) pumps are inactivated and together with further ionic disturbances, likely precipitate muscle fatigue.......Membrane excitability is a critical regulatory step in skeletal muscle contraction and is modulated by local ionic concentrations, conductances, ion transporter activities, temperature, and humoral factors. Intense fatiguing contractions induce cellular K(+) efflux and Na(+) and Cl(-) influx......, causing pronounced perturbations in extracellular (interstitial) and intracellular K(+) and Na(+) concentrations. Muscle interstitial K(+) concentration may increase 1- to 2-fold to 11-13 mM and intracellular K(+) concentration fall by 1.3- to 1.7-fold; interstitial Na(+) concentration may decline by 10 m...

  20. Osmotic and ionic effects of NaCl and Na2SO4 salinity on Phragmites australis

    DEFF Research Database (Denmark)

    Pagter, Majken; Bragato, Claudia; Malagoli, Mario

    2009-01-01

    and partly Cl ions from the leaves. Incomplete exclusion of Cl from the leaves may affect aboveground biomass production, which was significantly more reduced by NaCl than Na2SO4. Stomatal conductance was negatively influenced by decreasing water potentials caused by NaCl or Na2SO4, implying that a non...

  1. Structure-function relationships of Na+, K+, ATP, or Mg2+ binding and energy transduction in Na,K-ATPase

    DEFF Research Database (Denmark)

    Jorgensen, Peter L.; Pedersen, Per Amstrup

    2000-01-01

    Na,K-ATPase; Mutagenesis; Na+ binding; K+ binding; Tl+ binding; Mg2+ binding; ATP binding; Cation binding site; Energy transduction......Na,K-ATPase; Mutagenesis; Na+ binding; K+ binding; Tl+ binding; Mg2+ binding; ATP binding; Cation binding site; Energy transduction...

  2. Long-Range Effects of Na(+) Binding in Na,K-ATPase Reported by ATP.

    Science.gov (United States)

    Middleton, David A; Fedosova, Natalya U; Esmann, Mikael

    2015-12-01

    This paper addresses the question of long-range interactions between the intramembranous cation binding sites and the cytoplasmic nucleotide binding site of the ubiquitous ion-transporting Na,K-ATPase using (13)C cross-polarization magic-angle spinning (CP-MAS) solid-state nuclear magnetic resonance. High-affinity ATP binding is induced by the presence of Na(+) as well as of Na-like substances such as Tris(+), and these ions are equally efficient promoters of nucleotide binding. CP-MAS analysis of bound ATP with Na,K-ATPase purified from pig kidney membranes reveals subtle differences in the nucleotide interactions within the nucleotide site depending on whether Na(+) or Tris(+) is used to induce binding. Differences in chemical shifts for ATP atoms C1' and C5' observed in the presence of Na(+) or Tris(+) suggest alterations in the residues surrounding the bound nucleotide, hydrogen bonding, and/or conformation of the ribose ring. This is taken as evidence of a long-distance communication between the Na(+)-filled ion sites in the membrane interior and the nucleotide binding site in the cytoplasmic domain and reflects the first conformational change ultimately leading to phosphorylation of the enzyme. Stopped-flow fluorescence measurements with the nucleotide analogue eosin show that the dissociation rate constant for eosin is larger in Tris(+) than in Na(+), giving kinetic evidence of the difference in structural effects of Na(+) and Tris(+). According to the recent crystal structure of the E1·AlF4(-)·ADP·3Na(+) form, the coupling between the ion binding sites and the nucleotide side is mediated by, among others, the M5 helix.

  3. Eletrencefalograma na síndrome parkinsoniana

    Directory of Open Access Journals (Sweden)

    José Geraldo Camargo Lima

    1973-09-01

    Full Text Available Foram estudados os eletrencefalogramas de 50 pacientes parkinsonianos livres de qualquer antecedente convulsivo, sendo registrados traçados anormais em 40% dos casos. A incidência de traçados anormais foi maior na síndrome parkinsoniana bilateral do que na unilateral (52% e 25%, respectivamente. Entre as anormalidades assinaladas foram as paroxísticas as mais freqüentes (65% dos casos, caracterizando-se predominantemente por surtos de ondas teta. O registro de anormalidades paroxísticas do tipo irritativo encontrado em três casos é salientado. Alterações da atividade de base foram assinaladas em 35% dos pacientes. A idade dos pacientes não parece ter tido importante papel na gênese das anormalidades eletrencefalográficas.

  4. Knjige o kartografskim projekcijama na internetu

    Directory of Open Access Journals (Sweden)

    Nedjeljko Frančula

    2011-12-01

    Full Text Available U ovom prikazu skrećemo pozornost na neke knjige o kartografskim projekcijama koje su prvobitno objavljene u tisku, a potom digitalizirane i besplatno stavljene na mrežu. Neke od tih knjiga nude se na mreži kao Google e-knjige. Google godinama skuplja knjige kojima su istekla autorska prava i digitalizira ih. Fotografira se svaka stranica te zatim spaja u jednu veliku fotografiju iz koje se izvlači tekst softverom OCR. Google čuva originalnu digitalnu fotografiju u svom arhivu, a izvučeni tekst pretvara u formate HTML, PDF ili EPUB. Google danas nudi više od milijun besplatnih e-knjiga (http://www.google.com/books.

  5. Tecnologia simplificada na enfermagem materno infantil

    Directory of Open Access Journals (Sweden)

    Selma Campestrini

    1991-09-01

    Full Text Available A autora apresenta três modelos de tecnologia simplificada da enfermagem materno infantil: o equipamento didático SEIO COBAIA para treinar exercícios e massagens da mama e mamilo; a peça indumentária SUPRETRAUMA - sutiã preventivo de traumatismo mamilar - usado por gestantes; e, a técnica para reverter mamilo umbilicado durante o puerperio imediato. Além de corroborar na promoção do aleitamento materno e na prevenção de desmame precoce, demonstra a possibilidade da enfermagem relacionar o saber teórico-científico com o saber tecnico-prático, na saúde da mulher e da criança, com tecnologia adequada às necessidades, à compreensão e ao bem estar da população.

  6. Hidroginástica na terceira idade

    OpenAIRE

    Paula, Karla Campos de; Paula, Débora Campos de

    1998-01-01

    O processo de envelhecimento no indivíduo saudável está relacionado com inúmeras alterações psicológicas e físicas que interferem na área motora, concorrendo para a inatividade e contribuindo para o aparecimento e agravamento de determinadas doenças, além de influenciar negativamente a realização das atividades de vida diária. Portanto, a prática de atividade física é fundamental para o idoso, não só na prevenção de doenças como na reabilitação de suas habilidades motoras, promovendo um estil...

  7. Labirintos na cidade contemporânea

    Directory of Open Access Journals (Sweden)

    Edson Luiz André de Sousa

    Full Text Available Este artigo pretende tensionar pontos de conexão e diluição de fronteiras entre as categorias público/privado, conversando com a literatura de Baudelaire e W. Benjamin, Fredric Jamenson e Marc Augé. Através da imagem do labirinto, símbolo da cidade antiga que se quis extinguir na cidade moderna, busca-se refletir sobre alguns caminhos e caminhantes considerados excedentes na cidade contemporânea. O cenário propulsor dessa reflexão é a experiência do jornal Boca de Rua, elaborado por moradores de rua na cidade de Porto Alegre.

  8. Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state.

    Science.gov (United States)

    Kanai, Ryuta; Ogawa, Haruo; Vilsen, Bente; Cornelius, Flemming; Toyoshima, Chikashi

    2013-10-10

    Na(+),K(+)-ATPase pumps three Na(+) ions out of cells in exchange for two K(+) taken up from the extracellular medium per ATP molecule hydrolysed, thereby establishing Na(+) and K(+) gradients across the membrane in all animal cells. These ion gradients are used in many fundamental processes, notably excitation of nerve cells. Here we describe 2.8 Å-resolution crystal structures of this ATPase from pig kidney with bound Na(+), ADP and aluminium fluoride, a stable phosphate analogue, with and without oligomycin that promotes Na(+) occlusion. These crystal structures represent a transition state preceding the phosphorylated intermediate (E1P) in which three Na(+) ions are occluded. Details of the Na(+)-binding sites show how this ATPase functions as a Na(+)-specific pump, rejecting K(+) and Ca(2+), even though its affinity for Na(+) is low (millimolar dissociation constant). A mechanism for sequential, cooperative Na(+) binding can now be formulated in atomic detail.

  9. A perda de chance na responsabilidade civil

    OpenAIRE

    Silva, Rute Eunice Andrade Teixeira da

    2017-01-01

    Resumo: O presente trabalho tem como objecto de estudo a teoria da perda de chance. Tema ainda controverso tanto na doutrina como na jurisprudência, urge fazer-se uma análise do mesmo no âmbito do direito português. Para um melhor entendimento sobre a figura da perda de chance, é necessário ter presente alguns aspectos do instituto da responsabilidade civil. Será realizada uma análise geral dos pressupostos da responsabilidade civil, versando-nos principalmente sobre o dano e o ne...

  10. O trabalho na África subsariana

    OpenAIRE

    Carneiro, Emmanuel Moreira

    2008-01-01

    A natureza do trabalho e do mercado de emprego na África subsariana está intrinsecamente ligado ao tipo de produção material dominante, à natureza das relações de produção estabelecidas, bem como ao inerente sistema de formação e distribuição do rendimento. É ainda profundamente condicionada pela evolução do processo de estruturação mundial do capitalismo, o qual se traduz, na fase actual, pelo que se convencionou designar mundialização e globalização.

  11. A TEOLOGIA LATINO-AMERICANA NA ENCRUZILHADA

    Directory of Open Access Journals (Sweden)

    Victor Codina

    1999-01-01

    Full Text Available As mudanças ocorridas no mundo, no fim dos anos 80, não podem deixar de afetar a Teologia latino-americana e, muito concretamente, a Teologia da Libertação (TdL, teologia que nasceu na América Latina na década de 701. A TdL encontra-se hoje numa encruzilhada: retroceder e dar marcha a ré? Continuar repetindo o que até agora foi dito, como se nada tivesse acontecido?

  12. A Imagem como Ruína

    Directory of Open Access Journals (Sweden)

    Míriam Volpe

    2001-12-01

    Full Text Available O dialogismo ente o filme Citizen Kane, de Orson Welles, e o poema “Kubla Khan”, de S.T. Coleridgé, é analisado, sendo evidenciados não só o tema em comum – o mito do Paraíso perdido – como também a similariedade na organização do disurso na justaposição das images, como fragmentos da memória a serem preservados.

  13. Sexualidade na velhice e qualidade de vida

    OpenAIRE

    Viana, Helena Brandão; Madruga, Vera Aparecida

    2010-01-01

    O objetivo deste trabalho, realizado por meio de uma revisão de literatura, foi abordar uma revisão literária sobre a influência da sexualidade na qualidade de vida deidosos, temática pouco discutida nas diferentes áreas de pesquisas sobre envelhecimento. Diante da escassez de bibliografia na cultura brasileira, apresentou-se uma revisão de literatura sobre envelhecimento junto à temática da sexualidade, trazendo uma trajetória histórica sobre estudos de sexualidade ao longo do tempo, discuti...

  14. E-GRADIVA NA PRIMERU OBRAVNAVE GLAGOLA

    OpenAIRE

    Kajtna, Tjaša

    2013-01-01

    Sodobne tehnologije so korenito spremenile današnji način življenja. Tako je tudi z izobraževanjem. Vedno več učiteljev ob klasičnih metodah poučevanja uporablja tudi nove pristope, ki so povezani s sodobnimi tehnologijami. V diplomskem delu je opredeljeno e-izobraževanje, predstavljene so nove tehnologije, ki se pojavljajo v povezavi z le-tem. V nadaljevanju sledi teoretična obravnava e-gradiv, ki ob podpori informacijsko komunikacijskih tehnologij predstavljajo temelj e-izobraževanja. ...

  15. ANALIZA IZGUB NA OSLABLJENEM PRENAPETOSTNEM ODVODNIKU

    OpenAIRE

    Ajdnik, Miran

    2011-01-01

    Diplomska naloga obravnava problematiko izgub električne energije na oslabljenem prenapetostnem odvodniku na transformatorski postaji Kot-Makej (0,95/0,4 kV) in neozemljenem izvoru. Omenjena transformatorska postaja se napaja iz razdelilne transformatorske postaje Ravne (RTP RAVNE) preko 20 kV daljnovoda Mežica in transformatorske postaje Kot (20/0,95/0,4 kV). Rešitev je predstavljena s programskim orodjem MATLAB/Simulink iz knjižnice PowerSystem, s katerim je izvedena simulacija pri oslablje...

  16. Vpliv tripsinizacije na celice Caco-2.

    OpenAIRE

    Cuculić, Nika

    2018-01-01

    Caco-2 celična linija se uporablja v številnih predkliničnih raziskavah. Ena izmed najbolj izraženih lastnosti celične linije Caco-2 je njihova zmožnost spontane diferenciacije. Zaradi različnega rokovanja s celično linijo Caco-2 med laboratoriji, v kar spada tudi uporaba različnih koncentracij tripsina ter čas izpostavljenosti celic tripsinu, se rezultati raziskav med laboratoriji lahko zelo razlikujejo in niso primerljivi. Preverili smo vpliv različnih koncentracij tripsina na celično viabi...

  17. Izbor i prilagodba nadogradnje na implantatima

    OpenAIRE

    Belamarić, Sara

    2017-01-01

    Implantatne nadogradnje su spojni elementi između tijela implantata, kirurški postavljenog u kost, koji predstavlja zamjenu za prirodni korijen zuba i protetske suprastrukture kojom se nadoknađuje oblik, boja i funkcija zuba koji nedostaje. One predstavljaju središte funkcijskih i estetskih aspekata implantološke terapije. Imaju direktan utjecaj na dugoročnu prognozu i uspjeh ovog terapijskog postupka. Danas na tržištu postoji čitav niz dostupnih implantatnih nadogradnji. Najčešći materijali ...

  18. Recent results and prospects from NA62

    Directory of Open Access Journals (Sweden)

    Bizzeti Andrea

    2016-01-01

    K+ → π+ vv̄ is a theoretically very clean decay where indirect effects of new physics may be detectable. The NA62 apparatus has been significantly upgraded between 2008 and 2014 in order to measure the branching ratio of this decay with 10% precision. The NA62 experiment took data with the new setup in pilot runs in 2014 and 2015, reaching the design beam intensity. Results of first data quality studies in view of the 2016-2017 physics runs are presented.

  19. MEDGENERACIJSKI PRENOS ZNANJA NA DELOVNEM MESTU

    OpenAIRE

    Movern, Tina

    2015-01-01

    Prenos znanja med ljudmi igra ključno vlogo pri razvoju ter napredku človeštva. Nekaterih najbolj kompleksnih znanj kot so jeziki in kulturne norme, so lahko naučena oziroma priučena od drugih ljudi, ti pa so jih pridobili od prejšnjih generacij. Kot glavno gonilno silo razvoja neke organizacije bi prav lahko vzeli količino, kvaliteto in možnost upravljanja prenosa znanj v sami organizaciji, kar je tudi glavni predmet naše raziskave. Diplomska naloga je razdeljena na teoretični in empiri...

  20. Osteossarcoma parosteal: aspectos na radiologia convencional

    OpenAIRE

    Nanci Neto,Francisco; Marchiori,Edson; Vianna,Alberto Domingues; Aymoré,Ierecê Lins; Almeida,Ana Luiza Brito de; Irion,Klaus L.; Collares,Felipe Birchal

    2007-01-01

    OBJETIVO: Avaliar os achados clínicos mais importantes do osteossarcoma parosteal e descrever os seus aspectos mais comuns na radiologia convencional. MATERIAIS E MÉTODOS: Estudo retrospectivo com 26 pacientes com osteossarcoma parosteal, provenientes do arquivo do Clube do Osso, Rio de Janeiro, RJ, e análise dos principais achados clínicos e aspectos radiológicos. RESULTADOS: A doença predominou em pacientes do sexo feminino e teve idade média de acometimento na terceira década de vida. Os a...

  1. O problema do conhecimento verdadeiro na epidemiologia

    Directory of Open Access Journals (Sweden)

    Ayres José Ricardo de Carvalho Mesquita

    1992-01-01

    Full Text Available São examinadas as bases filosóficas da validação do conhecimento científico, com o intuito de estabelecer uma visão crítica a respeito da adoção das proposições de Popper na epidemiologia. Ressalta-se o caráter conservador que resulta das limitações técnicas implicadas na sua adoção, não obstante o evidente aumento da racionalidade e da criatividade heurística que propicia.

  2. Na+/K+-ATPase: Activity and inhibition

    Science.gov (United States)

    Čolović, M.; Krstić, D.; Krinulović, K.; Momić, T.; Savić, J.; Vujačić, A.; Vasić, V.

    2009-09-01

    The aim of the study was to give an overview of the mechanism of inhibition of Na+/K+-ATPase activity induced by some specific and non specific inhibitors. For this purpose, the effects of some ouabain like compounds (digoxin, gitoxin), noble metals complexes ([PtCl2DMSO2], [AuCl4]-, [PdCl4]2-, [PdCl(dien)]+, [PdCl(Me4dien)]+), transition metal ions (Cu2+, Zn2+, Fe2+, Co2+), and heavy metal ions (Hg2+, Pb2+, Cd2+) on the activity of Na+/K+-ATPase from rat synaptic plasma membranes (SPM), porcine cerebral cortex and human erythrocytes were discussed.

  3. Na, K-ATPase as signaling transducer

    OpenAIRE

    Li, Juan

    2007-01-01

    It is now generally agreed that Na,K-ATPase (NKA), in addition to its role in the maintenance of Na+ and K+ gradients across the cell membrane, is a signal transducer. Our group has identified a novel signaling pathway where NKA interact with IP3R to form a signaling microdomain. Ouabain, a specific ligand of NKA, activates this pathway, triggers slow Ca2+ oscillations and activates NF-κB. In current study, the molecular mechanisms and some important downstream effects of NK...

  4. Europlanet-2020 NA1 Exchange Program

    Science.gov (United States)

    Genzer, M.; Szego, K.; Haukka, H.; Harri, A.-M.

    2017-09-01

    The task of Exchange Program of NA1 is to support the activities of EPN2020 with experts and scientific exchange whenever it is needed. Short visits (up to 1 week) with the goal of improving infrastructure facilities and services offered to the scientific community are supported from this task. Since the start of the EPN2020 in September 2015 we have received and approved 14 applications for exchange program travel. More general and specifically targeted calls are planned for the future. The calls are announced on Europlanet-2020 NA1 web site.

  5. Abordagem neurologica na sindrome do X fragil

    OpenAIRE

    Marilisa Mantovani Guerreiro

    1993-01-01

    Resumo: Com o propósito de realizar a abordagem neurológica na Síndrome do X Frágil (SXF), estudaram-se 11 pacientes com este diagnóstico citogenético. A idade variou de 8 a 19 anos. Nove pacientes eram do sexo masculino e dois do feminino. Todos os indivíduos apresentaram pavilhões auriculares grandes e faces alongadas. Observou-se fronte proeminente em 63% dos casos e macrorquidia em 33% dentre aqueles do sexo masculino. Atraso na aquisição da fala, fala repetitiva, perseverativa, impulsiva...

  6. MANAGEMENT DOGODKOV NA PRIMERU NIKE KONVENCIJE

    OpenAIRE

    Kapić, Sara

    2010-01-01

    V diplomski nalogi je predstavljen potek ustvarjanja in izvedbe dogodka, ki zajema številne aktivnosti, in sicer na primeru Nike konvencije. Namen diplomske naloge je namreč podati kritično oceno izvajanja aktivnosti, z namenom ugotoviti, katere aktivnosti bi se v okviru upravljanja z dogodkom lahko izpeljale boljše in podati predloge za uspešnejšo zasnovo in organizacijo naslednje Nike konvencije. Na podlagi posnetka je ugotovljeno, da je pri organizaciji, vodenju, izvedbi in nadzoru prihaja...

  7. Alterações cognitivas na esquizofrenia

    OpenAIRE

    THEIL, Ruth Bonow

    2003-01-01

    Este estudo é uma revisão da literatura sobre o comprometimento cognitivo na esquizofrenia. Objetivou-se a análise da natureza e do padrão desse comprometimento, o estabelecimento de associações entre as variáveis clínicas e o desempenho neuropsicológico, e a determinação das correlações entre os déficits cognitivos na esquizofrenia e seus substratos neurais subjacentes. Foram inicialmente revistos os conceitos de esquizofrenia e sua evolução histórica, aspectos clínicos, cl...

  8. IDENTIDADE E CORPO NA MARCHA DAS VADIAS

    OpenAIRE

    Ribeiro Quintanilha de Souza, Aline

    2015-01-01

    O objetivo deste trabalho é analisar os temas de identidade de gênero e corporalidade na Marcha das Vadias. Esta é um movimento social que tem recebido visibilidade e experimentado um grande crescimento em adeptos e importância para as questões de gênero no Brasil. Este trabalho busca entender como práticas corporais são construídas para um objetivo político específico. Pretendo relacionar as principais reivindicações políticas desenvolvidas na manifestação com a construção da identidade "vad...

  9. Glutathionylation-Dependence of Na(+)-K(+)-Pump Currents Can Mimic Reduced Subsarcolemmal Na(+) Diffusion.

    Science.gov (United States)

    Garcia, Alvaro; Liu, Chia-Chi; Cornelius, Flemming; Clarke, Ronald J; Rasmussen, Helge H

    2016-03-08

    The existence of a subsarcolemmal space with restricted diffusion for Na(+) in cardiac myocytes has been inferred from a transient peak electrogenic Na(+)-K(+) pump current beyond steady state on reexposure of myocytes to K(+) after a period of exposure to K(+)-free extracellular solution. The transient peak current is attributed to enhanced electrogenic pumping of Na(+) that accumulated in the diffusion-restricted space during pump inhibition in K(+)-free extracellular solution. However, there are no known physical barriers that account for such restricted Na(+) diffusion, and we examined if changes of activity of the Na(+)-K(+) pump itself cause the transient peak current. Reexposure to K(+) reproduced a transient current beyond steady state in voltage-clamped ventricular myocytes as reported by others. Persistence of it when the Na(+) concentration in patch pipette solutions perfusing the intracellular compartment was high and elimination of it with K(+)-free pipette solution could not be reconciled with restricted subsarcolemmal Na(+) diffusion. The pattern of the transient current early after pump activation was dependent on transmembrane Na(+)- and K(+) concentration gradients suggesting the currents were related to the conformational poise imposed on the pump. We examined if the currents might be accounted for by changes in glutathionylation of the β1 Na(+)-K(+) pump subunit, a reversible oxidative modification that inhibits the pump. Susceptibility of the β1 subunit to glutathionylation depends on the conformational poise of the Na(+)-K(+) pump, and glutathionylation with the pump stabilized in conformations equivalent to those expected to be imposed on voltage-clamped myocytes supported this hypothesis. So did elimination of the transient K(+)-induced peak Na(+)-K(+) pump current when we included glutaredoxin 1 in patch pipette solutions to reverse glutathionylation. We conclude that transient K(+)-induced peak Na(+)-K(+) pump current reflects the effect

  10. In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition

    DEFF Research Database (Denmark)

    Zhang, Y; Norian, J M; Magyar, C E

    1999-01-01

    The aim of this study was to test the hypothesis that in vivo administration of parathyroid hormone (PTH) provokes diuresis/natriuresis through redistribution of proximal tubule apical sodium cotransporters (NHE3 and NaPi2) to internal stores and inhibition of basolateral Na-K-ATPase activity....../diuresis and NHE3 and NaPi2 internalization, and that Na-K-ATPase inhibition is not secondary to depressed apical Na+ transport....

  11. Water transport by the renal Na(+)-dicarboxylate cotransporter

    DEFF Research Database (Denmark)

    Meinild, A K; Loo, D D; Pajor, A M

    2000-01-01

    This study investigated the ability of the renal Na(+)-dicarboxylate cotransporter, NaDC-1, to transport water. Rabbit NaDC-1 was expressed in Xenopus laevis oocytes, cotransporter activity was measured as the inward current generated by substrate (citrate or succinate), and water transport...... was monitored by the changes in oocyte volume. In the absence of substrates, oocytes expressing NaDC-1 showed an increase in osmotic water permeability, which was directly correlated with the expression level of NaDC-1. When NaDC-1 was transporting substrates, there was a concomitant increase in oocyte volume....... This solute-coupled influx of water took place in the absence of, and even against, osmotic gradients. There was a strict stoichiometric relationship between Na(+), substrate, and water transport of 3 Na(+), 1 dicarboxylate, and 176 water molecules/transport cycle. These results indicate that the renal Na...

  12. Intracellular Na(+) and metabolic modulation of Na/K pump and excitability in the rat suprachiasmatic nucleus neurons.

    Science.gov (United States)

    Wang, Yi-Chi; Yang, Jyh-Jeen; Huang, Rong-Chi

    2012-10-01

    Na/K pump activity and metabolic rate are both higher during the day in the suprachiasmatic nucleus (SCN) that houses the circadian clock. Here we investigated the role of intracellular Na(+) and energy metabolism in regulating Na/K pump activity and neuronal excitability. Removal of extracellular K(+) to block the Na/K pump excited SCN neurons to fire at higher rates and return to normal K(+) to reactivate the pump produced rebound hyperpolarization to inhibit firing. In the presence of tetrodotoxin to block the action potentials, both zero K(+)-induced depolarization and rebound hyperpolarization were blocked by the cardiac glycoside strophanthidin. Ratiometric Na(+) imaging with a Na(+)-sensitive fluorescent dye indicated saturating accumulation of intracellular Na(+) in response to pump blockade with zero K(+). The Na(+) ionophore monensin also induced Na(+) loading and hyperpolarized the membrane potential, with the hyperpolarizing effect of monensin abolished in zero Na(+) or by pump blockade. Conversely, Na(+) depletion with Na(+)-free pipette solution depolarized membrane potential but retained residual Na/K pump activity. Cyanide inhibition of oxidative phosphorylation blocked the Na/K pump to depolarize resting potential and increase spontaneous firing in most cells, and to raise intracellular Na(+) levels in all cells. Nonetheless, the Na/K pump was incompletely blocked by cyanide but completely blocked by iodoacetate to inhibit glycolysis, indicating the involvement of both oxidative phosphorylation and glycolysis in fueling the Na/K pump. Together, the results indicate the importance of intracellular Na(+) and energy metabolism in regulating Na/K pump activity as well as neuronal excitability in the SCN neurons.

  13. Presoja notranjih kontrol pri obračunu davka na dodano vrednost na primeru "Podjetja x"

    OpenAIRE

    Majcen, Borut

    2016-01-01

    Poslovanje podjetja si je ob odsotnosti notranjih kontrol nemogoče predstavljati. Podjetja so podvržena raznim tveganjem, še posebej v današnjih razmerah globalnega poslovanja, ko se podjetja soočajo z vedno novimi izzivi, kar prinaša tudi nova tveganja. Najučinkovitejši ukrep za obvladovanje tveganj predstavlja vzpostavitev sistema notranjih kontrol. Obvladovanje tveganj pa ne poteka samo na ravni podjetja kot celote, ampak je prisotno na vseh področjih delovanja podjetja, torej tudi na p...

  14. (1) Na-Allah et al

    African Journals Online (AJOL)

    Adeyinka Odunsi

    Na-Allah, Y., Zamnao, A. *Garba, S. and Abdullahi, A. U.. Department of Animal Science, Faculty of Agriculture,. Usmanu Danfodiyo University, P. M. B. 2346, Sokoto-Nigeria. *Corresponding author: email; sanigarba2003@yahoo.com Phone no. +234(0)8067090255. Abstract. This study evaluated the pre-‐weaning growth ...

  15. Habitus professoral na sala de aula virtual

    Directory of Open Access Journals (Sweden)

    Alexandre Marinho Pimenta

    2014-09-01

    Full Text Available Entendendo que a indiferença na ação pedagógica contribui para a reprodução das desigualdades no sistema de ensino, o presente artigo busca captar, a partir de entrevistas semiestruturadas, traços do habitus de professores supervisores de disciplinas do curso de Licenciatura em Pedagogia na modalidade a distância na Universidade de Brasília - UnB no âmbito do Sistema Universidade Aberta do Brasil - UAB. As orientações metodológicas de Bourdieu (2007 foram um dos elementos orientadores na análise das entrevistas, considerando ainda o uso heurístico do conceito de habitus. Conclui-se que o habitus professoral envolve esforços voluntários em busca de uma ação pedagógica diferenciada. No entanto, ele é ambíguo e condescendente frente aos limites do modelo de EaD no âmbito da UAB. Ao fim, os dados analisados permitem fornecer elementos para reorientação político-pedagógica que vise a um novo modelo de EaD nacional.

  16. Le Hodler d'Iéna

    OpenAIRE

    2017-01-01

    Suites de la protestation contre le bombardement de la cathédrale de Reims. Nouvelle proposition de M. Gunsburger pour le rachat du tableau de Hodler "Départ des étudiants d'Iéna pour la guerre de libération contre Napoléon en 1813".

  17. Study of deconfinement in NA50

    Indian Academy of Sciences (India)

    Corrado Cicalo

    from the forward hadronic energy measured in the very forward hadronic calorimeter. 2. Experimental setup and data selection. The NA50 apparatus [6] mainly consists of a muon spectrometer, a segmented active target and three independent centrality detectors: an electromagnetic calorimeter which measures the neutral ...

  18. Pijn tijdens of na de wortelkanaalbehandeling

    NARCIS (Netherlands)

    Wesselink, P.R.

    2012-01-01

    Een wortelkanaalbehandeling kan pijn veroorzaken tijdens en/of na de behandeling. Tijdens de behandeling moet dan onderscheid worden gemaakt tussen pijn bij een pulpitis en pijn bij een necrotische pulpa. In beide gevallen kan die pijn effectief worden bestreden, afhankelijk van de toestand waarin

  19. Leitura na escola: um barco à deriva?

    Directory of Open Access Journals (Sweden)

    Teixeira, Marlene

    2008-01-01

    Full Text Available Este artigo busca, na teoria da enunciação de É. Benveniste, elementos para repensar o trabalho com a leitura na escola. Considera que, na discussão das noções gêmeas de forma e sentido, o autor formula uma concepção de significado que, de um lado, pode deter a interpretação à deriva, implicada na visão de leitura centrada no leitor, e, de outro lado, possibilita que se transcenda a idéia de que é pela decifração mdo código que se dá o processo de construção do significado. Conclui que, no processo de leitura, é sempre de um trabalho com a língua que se trata, trabalho que se renova a cada ato de aproximação do aluno com o texto, porque a língua é submetida ao ato de enunciação

  20. NA49: lead-lead collision

    CERN Multimedia

    1996-01-01

    This is an image of an actual lead ion collision taken from tracking detectors on the NA49 experiment, part of the heavy ion project at CERN. These collisions produce a very complicated array of hadrons as the heavy ions break up. It is hoped that one of these collisions will eventually create a new state of matter known as quark-gluon plasma.

  1. Nucleotide binding to Na+/K+-ATPase

    Czech Academy of Sciences Publication Activity Database

    Kubala, Martin; Lánský, Zdeněk; Ettrich, R.; Plášek, J.; Teisinger, Jan; Amler, Evžen

    2005-01-01

    Roč. 272, č. S1 (2005), s. 191-191 E-ISSN 1742-4658. [FEBS Congress /30./ and IUBMB Conference /9./. 02.07.2005-07.07.2005, Budapest] Keywords : Na+/K+- ATPase * ATP binding * TNP-ATP Subject RIV: BO - Biophysics

  2. Therapy of hyperthyroidism with Na131I

    International Nuclear Information System (INIS)

    Kakehi, Hirotake; Furukawa, Takashi; Fukakusa, Shunichi; Futonaka, Hiroshi; Takahashi, Yuji

    1984-01-01

    Forty one patients of hyperthyroidism were treated with Na 131 I. Men and women are in the ratio 1:3.1. The ages of patients are between twenties and sixties and the forties are the highest in number. The observation period of clinical courses is between 1 and 8 years. The number of patients observed over 5 years are 51% of them and over 2 years are 83%. The treatment frequency is as follows: On 37 cases each one was treated once with Na 131 I. 2 cases twice, 1 case at 4 times in 3 years and 1 case at 5 times in 6 years. The treatment doses are between 4,000-6,000 rad (40-60 Gray). In the cases treated with the irradiation dose of 6,000 rad, we often saw hypothyroidism. In cases aiming 4,000-5,000 rad, there is a tendency of leaving hyperthyroidism unrecovered. In conclusion, the patients should be treated giving 4,000-5,000 rad or with Na 131 I doses of 3-6mCi. If the effects of the treatment are insufficient, the patients should be further treated with anti-thyroid drug or treated again with Na 131 I. As the result, there are at present 25 cases (61.0%) in normal status of the thyroid gland, 12 cases (29.2%) in hyperthyroidism and 4 cases (9.8%) in hypothyroidism totaling 41 cases in all. (author)

  3. NA48: Wiring up for Change

    CERN Multimedia

    2001-01-01

    The NA48 Collaboration is rebuilding its drift chambers ready for the experiment to start up again this coming July. An intricate task involving the soldering of over 24,000 wires! The future of the NA48 experiment is coming right down to the wire, that is, the wires which the Collaboration is installing in the clean room of Hall 887 on the Prévessin site. Six days a week, technicians are working in shifts to rebuild the experiment's drift chambers. The original chambers were damaged when a section of a vacuum tube imploded at the end of 1999. A year ago, CERN gave the green light for this essential part of the spectrometer to be rebuilt, so the NA48 experiment, which studies CP violation (see box), still has a bright future ahead of it. Three years of data-taking ahead The NA48 experiment aims to penetrate the secrets of CP (Charge Parity) violation. Charge and parity are two parameters which distinguish a particle from an antiparticle. In other words, an electron possesses a negative electric ...

  4. Study of deconfinement in NA50

    Indian Academy of Sciences (India)

    Corrado Cicalo

    The anomalous J/ψ pattern suppression observed in NA50 experiment is a clear evidence of the transition to a deconfined state of matter. Acknowledgements. This work was partially supported by Fundaç˜ao para a Ciência e a Tecnologia, by INTAS grant 96-0231 and by the Russian Foundation for Fundamental Research, ...

  5. Zasvojenost z igrami na srečo : magistrsko delo

    OpenAIRE

    Rozman, Patricia

    2014-01-01

    Namen magistrske naloge je predstaviti eno izmed najbolj skritih oblik zasvojenosti, to je zasvojenost z igrami na srečo. Zanimalo me je, kako ta oblika zasvojenosti vpliva na posameznika, tako telesno kot duševno. Ali posameznikova zasvojenost vpliva na ljudi okoli njega, na njegovo družino, prijatelje, znance in službo, ter kako se zasvojenec s tem sooča. Predvsem me je zanimalo, ali zasvojenost z igrami na srečo vodi v kriminalna dejanja in kakšna so ta dejanja ter kako je to ureje...

  6. VPLIV BARVE EMBALAŽE NA ZAZNAVANJE OKUSA GOSTEGA SOKA

    OpenAIRE

    Prevolšek, Daša

    2016-01-01

    Z barvami se srečujemo na vsakem koraku. Mogoče se njihovega vpliva ne zavedamo povsem, vendar nam lahko že pogled na določeno barvo dvigne ali pokvari razpoloženje. Barve imajo zelo velik vpliv na človeka in v nas prebujajo različna čustva. Nekatere barve so pozitivne in nas osrečujejo, druge pa na nas delujejo negativno. Ravno zaradi tega je tudi za oblikovalce embalaže zelo pomembno, da vnaprej predvidijo, kako se bodo potencialni porabniki njihovega izdelka odzivali na njihovo embalažo. P...

  7. IZOBRAŽEVANJE NA DOMU - ŠTUDIJA PRIMERA

    OpenAIRE

    Križan, Urška

    2014-01-01

    V teoretičnem delu se skozi literaturo seznanjamo z zakoni, ki na območju Republike Slovenije urejajo izobraževanje na domu, pa tudi s smernicami, ki veljajo na področju organiziranosti takega pouka. Po enem tednu, ki smo ga preživeli na domačiji skupaj s tremi šoloobveznimi otroki, ki se šolajo na domu, ugotavljamo, da je izvajanje izobraževanja na domu zmeraj v skladu z zakoni in pogosto v skladu s smernicami.

  8. Dicty_cDB: Contig-U01028-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available , BAC clone: RNB1-142B13, 5'... 36 0.26 3 ( FC835657 ) CBHI6246.rev CBHI Metridium senile tentacle Metri... ...agen, partial cds. 40 0.89 2 ( FC834206 ) CBHI5463.fwd CBHI Metridium senile tentacle Metri... 40 0.90 2 ( C...F655243 ) tac86g11.y1 Hydra EST -IV Hydra magnipapillata cD... 40 0.90 2 ( FC836287 ) CBHI6585.fwd CBHI Metridium senile tentacle...NA ... 48 1.0 1 ( FC831009 ) CBHI3780.fwd CBHI Metridium senile tentacle Metri... 48 1.0 1 ( EY924105 ) RR4D...0 ) CBHI5256.fwd CBHI Metridium senile tentacle Metri... 40 1.1 2 ( AC178239 ) Strongylocentrotus purpuratus

  9. Effects of non-uniform root zone salinity on water use, Na+ recirculation, and Na+ and H+ flux in cotton.

    Science.gov (United States)

    Kong, Xiangqiang; Luo, Zhen; Dong, Hezhong; Eneji, A Egrinya; Li, Weijiang

    2012-03-01

    A new split-root system was established through grafting to study cotton response to non-uniform salinity. Each root half was treated with either uniform (100/100 mM) or non-uniform NaCl concentrations (0/200 and 50/150 mM). In contrast to uniform control, non-uniform salinity treatment improved plant growth and water use, with more water absorbed from the non- and low salinity side. Non-uniform treatments decreased Na(+) concentrations in leaves. The [Na(+)] in the '0' side roots of the 0/200 treatment was significantly higher than that in either side of the 0/0 control, but greatly decreased when the '0' side phloem was girdled, suggesting that the increased [Na(+)] in the '0' side roots was possibly due to transportation of foliar Na(+) to roots through phloem. Plants under non-uniform salinity extruded more Na(+) from the root than those under uniform salinity. Root Na(+) efflux in the low salinity side was greatly enhanced by the higher salinity side. NaCl-induced Na(+) efflux and H(+) influx were inhibited by amiloride and sodium orthovanadate, suggesting that root Na(+) extrusion was probably due to active Na(+)/H(+) antiport across the plasma membrane. Improved plant growth under non-uniform salinity was thus attributed to increased water use, reduced leaf Na(+) concentration, transport of excessive foliar Na(+) to the low salinity side, and enhanced Na(+) efflux from the low salinity root.

  10. Synthesis of Na-A and/or Na-X zeolite/porous carbon composites from carbonized rice husk

    Science.gov (United States)

    Katsuki, Hiroaki; Komarneni, Sridhar

    2009-07-01

    Na-A and/or Na-X zeolite/porous carbon composites were prepared under hydrothermal conditions by NaOH dissolution of silica first from carbonized rice husk followed by addition of NaAlO 2 and in situ crystallization of zeolites i.e., using a two-step process. When a one-step process was used, both Na-A and Na-X zeolites crystallized on the surface of carbon. Na-A or Na-X zeolite crystals were prepared on the porous carbonized rice husk at 90 °C for 2-6 h by changing the SiO 2/Al 2O 3, H 2O/Na 2O and Na 2O/SiO 2 molar ratios of precursors in the two-step process. The surface area and NH 4+-cation exchange capacity (CEC) of Na-A zeolite/porous carbon were found to be 171 m 2/g and 506 meq/100 g, respectively, while those of Na-X zeolite/porous carbon composites were 676 m 2/g and 317 meq/100 g, respectively. Na-A and Na-X zeolites are well-known microporous and hydrophilic materials while carbonized rice husk was found to be mesoporous (pores of ˜3.9 nm) and hydrophobic. These hybrid microporous-mesoporous and hydrophilic-hydrophobic composites are expected to be useful for decontamination of metal cations as well as organic contaminants simultaneously.

  11. Batrachotoxin-activated Na+ channels in planar lipid bilayers. Competition of tetrodotoxin block by Na+.

    Science.gov (United States)

    Moczydlowski, E; Garber, S S; Miller, C

    1984-11-01

    Single Na+ channels from rat skeletal muscle plasma membrane vesicles were inserted into planar lipid bilayers formed from neutral phospholipids and were observed in the presence of batrachotoxin. The batrachotoxin-modified channel activates in the voltage range -120 to -80 mV and remains open almost all the time at voltages positive to -60 mV. Low levels of tetrodotoxin (TTX) induce slow fluctuations of channel current, which represent the binding and dissociation of single TTX molecules to single channels. The rates of association and dissociation of TTX are both voltage dependent, and the association rate is competitively inhibited by Na+. This inhibition is observed only when Na+ is increased on the TTX binding side of the channel. The results suggest that the TTX receptor site is located at the channel's outer mouth, and that the Na+ competition site is not located deeply within the channel's conduction pathway.

  12. High-temperature phases of NaNbO3 and NaTaO3.

    Science.gov (United States)

    Darlington; Knight

    1999-02-01

    The high-temperature phases of the perovskites sodium niobate, NaNbO(3), and sodium tantalate, NaTaO(3), have been re-examined using the high-resolution powder diffractometer HRPD at the ISIS neutron spallation source; the two materials show the same sequence of phases with tilted octahedra. Diffraction patterns were measured every 5 K allowing structural changes with temperature within a single phase to be determined for the first time. Previous structure determinations within one phase had been performed at a single temperature only. The octahedra are tilted about pseudocubic directions and are also deformed; the magnitude of the deformation is shown to be proportional to the square of the angle of tilt as expected from a phenomenological theory applied to such transitions. The structures of NaNbO(3) between 753 and 793 K and of NaTaO(3) below 758 K are not as reported in the literature.

  13. Transmural gradients in Na/K pump activity and [Na+]I in canine ventricle.

    Science.gov (United States)

    Gao, J; Wang, W; Cohen, I S; Mathias, R T

    2005-09-01

    There are well-documented differences in ion channel activity and action potential shape between epicardial (EPI), midmyocardial (MID), and endocardial (ENDO) ventricular myocytes. The purpose of this study was to determine if differences exist in Na/K pump activity. The whole cell patch-clamp was used to measure Na/K pump current (I(P)) and inward background Na(+)-current (I(inb)) in cells isolated from canine left ventricle. All currents were normalized to membrane capacitance. I(P) was measured as the current blocked by a saturating concentration of dihydro-ouabain. [Na(+)](i) was measured using SBFI-AM. I(P)(ENDO) (0.34 +/- 0.04 pA/pF, n = 17) was smaller than I(P)(EPI) (0.68 +/- 0.09 pA/pF, n = 38); the ratio was 0.50 with I(P)(MID) being intermediate (0.53 +/- 0.13 pA/pF, n = 19). The dependence of I(P) on [Na(+)](i) or voltage was essentially identical in EPI and ENDO (half-maximal activation at 9-10 mM [Na(+)](i) or approximately -90 mV). Increasing [K(+)](o) from 5.4 to 15 mM caused both I(P)(ENDO) and I(P)(EPI) to increase, but the ratio remained approximately 0.5. I(inb) in EPI and ENDO were nearly identical ( approximately 0.6 pA/pF). Physiological [Na(+)](i) was lower in EPI (7 +/- 2 mM, n = 31) than ENDO (12 +/- 3 mM, n = 29), with MID being intermediate (9 +/- 3 mM, n = 22). When cells were paced at 2 Hz, [Na(+)](i) increased but the differences persisted (ENDO 14 +/- 3 mM, n = 10; EPI 9 +/- 2 mM, n = 10; and MID intermediate, 11 +/- 2 mM, n = 9). Based on these results, the larger I(P) in EPI appears to reflect a higher maximum turnover rate, which implies either a larger number of active pumps or a higher turnover rate per pump protein. The transmural gradient in [Na(+)](i) means physiological I(P) is approximately uniform across the ventricular wall, whereas transporters that utilize the transmembrane electrochemical gradient for Na(+), such as Na/Ca exchange, have a larger driving force in EPI than ENDO.

  14. Isotope separation of 22Na and 24Na with using light induced drift effect

    International Nuclear Information System (INIS)

    Hradecny, C.; Tethal, T.; Ermolaev, I.M.; Zemlyanoj, S.G.; Zuzaan, P.

    1993-01-01

    The LIDIS (Light Drift Isotope Separation) separator without a gas flow is discussed. It is shown, that atomization degree of the separated isotopes limited real separation coefficient. The better buffer gas purification allowed to increase the experimental separation factor of 22 Na and 24 Na isotopes up to 25. The new experimental set up allow to increase the separation efficiency up to 50%. 12 refs.; 5 figs

  15. Intracellular Na+ regulation of Na+ pump sites in cultured vascular smooth muscle cells

    International Nuclear Information System (INIS)

    Allen, J.C.; Navran, S.S.; Seidel, C.L.; Dennison, D.K.; Amann, J.M.; Jemelka, S.K.

    1989-01-01

    Enzymatically dispersed cells from canine saphenous vein and femoral artery were grown in fetal calf serum and studied at day 0 (freshly dispersed) through confluence in primary culture. Intracellular Na levels (Nai), but not intracellular K (Ki), were increased after 24 h in culture and then decreased to a steady state by 4 days. Na+ pump site number [( 3 H] ouabain binding) increased through day 3 and remained elevated. Nai was still elevated at 2 days when the Na+ pump site number began to increase. Total pump turnover (maximum ouabain-inhibited 86 Rb uptake) reflected the increase in Na+ pump site number. These key events precede the observed increases in both protein production and cellular proliferation. If the same cells are maintained in defined medium, without fetal calf serum, Nai, Ki, and the number of [ 3 H]ouabain binding sites do not change with time. These data are consistent with the suggestion that the initial mitogenic response of vascular smooth muscle cells to fetal calf serum involves an increased Na+ influx, and a Nai accumulation, caused by low Na+ pump density. The synthesis of new pump sites effects a decrease in the accumulated Nai, which may be related to cell proliferation

  16. Na+-NQR (Na+-translocating NADH:ubiquinone oxidoreductase) as a novel target for antibiotics.

    Science.gov (United States)

    Dibrov, Pavel; Dibrov, Elena; Pierce, Grant N

    2017-09-01

    The recent breakthrough in structural studies on Na+-translocating NADH:ubiquinone oxidoreductase (Na+-NQR) from the human pathogen Vibrio cholerae creates a perspective for the systematic design of inhibitors for this unique enzyme, which is the major Na+ pump in aerobic pathogens. Widespread distribution of Na+-NQR among pathogenic species, its key role in energy metabolism, its relation to virulence in different species as well as its absence in eukaryotic cells makes this enzyme especially attractive as a target for prospective antibiotics. In this review, the major biochemical, physiological and, especially, the pharmacological aspects of Na+-NQR are discussed to assess its 'target potential' for drug development. A comparison to other primary bacterial Na+ pumps supports the contention that NQR is a first rate prospective target for a new generation of antimicrobials. A new, narrowly targeted furanone inhibitor of NQR designed in our group is presented as a molecular platform for the development of anti-NQR remedies. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  17. Active transport of Na/sup +/ by reconstituted Na,K-ATPase

    Energy Technology Data Exchange (ETDEWEB)

    Boldyrev, A.A.; Svinukhova, I.A.

    1987-02-20

    The ability of ATP, CTP, ITP, GTP, and UTP to support ouabain-sensitive accumulation of Na/sup +/ by proteoliposomes with a reconstituted Na/K-pump was investigated. At a low (Na/sup +/)/(K/sup +/) ratio in the medium (20 mM/50 mM), a correlation is observed between the proton-accepting capacity of the nucleotide and its effectiveness as a substrate of active transport. To test the hypothesis of the importance of the presence of a negative charge in the 1-position of the purine (3-pyrimidine) base of the nucleotide for mutual transitions between the Na- and K-conformations of Na,K-ATPase they used two analogs of ATP: N/sub 1/-hydroxy-ATP, possessing proton acceptor capacity, and N/sub 1/-methoxy-ATP, in the molecule of which the negative charge is quenched by a methyl group. The first substrate supports active accumulation of Na/sup +/ in proteoliposomes at the same rate as ATP, whereas the second substrate is relatively ineffective.

  18. Hidroginástica na terceira idade

    Directory of Open Access Journals (Sweden)

    Karla Campos de Paula

    1998-02-01

    Full Text Available O processo de envelhecimento no indivíduo saudável está relacionado com inúmeras alterações psicológicas e físicas que interferem na área motora, concorrendo para a inatividade e contribuindo para o aparecimento e agravamento de determinadas doenças, além de influenciar negativamente a realização das atividades de vida diária. Portanto, a prática de atividade física é fundamental para o idoso, não só na prevenção de doenças como na reabilitação de suas habilidades motoras, promovendo um estilo de vida saudável que é fator preponderante para a melhoria da qualidade de vida. Contudo, algumas precauções devem ser adotadas na prescrição da atividade direcionada para o idoso, a fim de que esta seja segura e prazerosa. Dentre os exercícios mais adequados aos idosos estão a caminhada, o ciclismo, a natação e a hidroginástica. Devido a sua grande procura, a hidroginástica vem aumentando o número de adeptos na terceira idade. Ela propicia ao idoso o aumento de sua capacidade aeróbia, força muscular, flexibilidade articular e o treinamento de habilidades específicas como equilíbrio e coordenação motora. Soma-se ainda o fato de esta atividade oferecer ambiente de relaxamento e incentivo ao contato social, atuando no combate ao estresse, depressão, na melhoria da autopercepção corporal e da auto-estima. Devemos, então, estar atentos às particularidades da hidroginástica, a fim de aproveitar todas as vantagens que esta oferece para o programa de exercícios direcionado para a terceira idade.

  19. Agmag Igbo dka Ngwar n'kwalite Ezi Nchekwa na Nkwsiike haobodo

    African Journals Online (AJOL)

    Ka Najira nwerechara onwe ya n'af 1960, olileanya tt mamala ya b na ihe ga-adz mma. Mana ka oge na-aga, a chptara na ihe na-akawanye nj. Usoro chch d iche iche daptara. Nd am na nd nkt achala mana nd gara n'ihu na-akawanye nj. O bu ihe doro anya na chch ha b nke nchgbu na fnfju akpa. N'agbanyegh na ...

  20. Transport of Na48 Drift Chambers to Dubna

    CERN Multimedia

    GOLOVATYUK, V

    2010-01-01

    On 22 July, in the occasion of the departure of the Na48 Drift Chambers from CERN, Mikhail Itkis (acting Director of the JIINR) and Rolf Heuer (CERN Director General) visited the NA62 experimental area.

  1. Angiotensin II-induced hypertension increases plasma membrane Na pump activity by enhancing Na entry in rat thick ascending limbs.

    Science.gov (United States)

    Gonzalez-Vicente, Agustin; Garvin, Jeffrey L

    2013-11-01

    Thick ascending limbs (TAL) reabsorb 30% of the filtered NaCl load. Na enters the cells via apical Na-K-2Cl cotransporters and Na/H exchangers and exits via basolateral Na pumps. Chronic angiotensin II (ANG II) infusion increases net TAL Na transport and Na apical entry; however, little is known about its effects on the basolateral Na pump. We hypothesized that in rat TALs Na pump activity is enhanced by ANG II-infusion, a model of ANG II-induced hypertension. Rats were infused with 200 ng·kg(-1)·min(-1) ANG II or vehicle for 7 days, and TAL suspensions were obtained. We studied plasma membrane Na pump activity by measuring changes in 1) intracellular Na (Nai) induced by ouabain; and 2) ouabain-sensitive oxygen consumption (QO2). We found that the ouabain-sensitive rise in Nai in TALs from ANG II-infused rats was 12.8 ± 0.4 arbitrary fluorescent units (AFU)·mg(-1)·min(-1) compared with only 9.9 ± 1.1 AFU·mg(-1)·min(-1) in controls (P Na pump expression, the number of Na pumps in the plasma membrane, or the affinity for Na. When furosemide (1.1 mg·kg(-1)·day(-1)) was coinfused with ANG II, no increase in plasma membrane Na pump activity was observed. We concluded that in ANG II-induced hypertension Na pump activity is increased in the plasma membrane of TALs and that this increase is caused by the chronically enhanced Na entry occurring in this model.

  2. Rescue of Na+ affinity in aspartate 928 mutants of Na+,K+-ATPase by secondary mutation of glutamate 314.

    Science.gov (United States)

    Holm, Rikke; Einholm, Anja P; Andersen, Jens P; Vilsen, Bente

    2015-04-10

    The Na(+),K(+)-ATPase binds Na(+) at three transport sites denoted I, II, and III, of which site III is Na(+)-specific and suggested to be the first occupied in the cooperative binding process activating phosphorylation from ATP. Here we demonstrate that the asparagine substitution of the aspartate associated with site III found in patients with rapid-onset dystonia parkinsonism or alternating hemiplegia of childhood causes a dramatic reduction of Na(+) affinity in the α1-, α2-, and α3-isoforms of Na(+),K(+)-ATPase, whereas other substitutions of this aspartate are much less disruptive. This is likely due to interference by the amide function of the asparagine side chain with Na(+)-coordinating residues in site III. Remarkably, the Na(+) affinity of site III aspartate to asparagine and alanine mutants is rescued by second-site mutation of a glutamate in the extracellular part of the fourth transmembrane helix, distant to site III. This gain-of-function mutation works without recovery of the lost cooperativity and selectivity of Na(+) binding and does not affect the E1-E2 conformational equilibrium or the maximum phosphorylation rate. Hence, the rescue of Na(+) affinity is likely intrinsic to the Na(+) binding pocket, and the underlying mechanism could be a tightening of Na(+) binding at Na(+) site II, possibly via movement of transmembrane helix four. The second-site mutation also improves Na(+),K(+) pump function in intact cells. Rescue of Na(+) affinity and Na(+) and K(+) transport by second-site mutation is unique in the history of Na(+),K(+)-ATPase and points to new possibilities for treatment of neurological patients carrying Na(+),K(+)-ATPase mutations. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  3. Characterization of Na+-linked and Na+-independent Cl-/HCO3- exchange systems in Chinese hamster lung fibroblasts

    International Nuclear Information System (INIS)

    Cassel, D.; Scharf, O.; Rotman, M.; Cragoe, E.J. Jr.; Katz, M.

    1988-01-01

    The PS120 variant of Chinese hamster lung fibroblasts which lacks Na + /H + exchange activity was used to investigate bicarbonate transport systems and their role in intracellular pH (pH/sub i/) regulation. When pH/sub i/ was decreased by acid load, bicarbonate caused pH/sub i/ increase and stimulated 36 Cl - efflux from the cells, both in a Na + -dependent manner. These results together with previous findings that bicarbonate stimulates 22 Na + uptake in PS120 cells demonstrate the presence of a Na + -linked Cl - /HCO 3 - exchange system. In cells with normal initial pH/sub i/, bicarbonate caused Na + -independent pH/sub i/ increase in Cl - -free solutions and stimulated Na + -independent 36 Cl - efflux, indicating that a Na + -independent Cl - /HCO 3 - exchanger is also present in the cell. Na + -linked and Na + -independent Cl - /HCO 3- exchange is apparently mediated by two distinct systems, since a [(tetrahydrofluorene-7-yl)oxy]acetic acid derivative selectively inhibits the Na + -independent exchanger. An additional distinctive features is a 10-fold lower affinity for chloride of the Na + -linked exchanger. The Na + -linked and Na + -independent Cl - /HCO 3 - exchange systems are likely to protect the cell from acid and alkaline load, respectively

  4. The two C-terminal tyrosines stabilize occluded Na/K pump conformations containing Na or K ions.

    Science.gov (United States)

    Vedovato, Natascia; Gadsby, David C

    2010-07-01

    Interactions of the three transported Na ions with the Na/K pump remain incompletely understood. Na/K pump crystal structures show that the extended C terminus of the Na,K-adenosine triphosphatase (ATPase) alpha subunit directly contacts transmembrane helices. Deletion of the last five residues (KETYY in almost all Na/K pumps) markedly lowered the apparent affinity for Na activation of pump phosphorylation from ATP, a reflection of cytoplasmic Na affinity for forming the occluded E1P(Na3) conformation. ATPase assays further suggested that C-terminal truncations also interfere with low affinity Na interactions, which are attributable to extracellular effects. Because extracellular Na ions traverse part of the membrane's electric field to reach their binding sites in the Na/K pump, their movements generate currents that can be monitored with high resolution. We report here electrical measurements to examine how Na/K pump interactions with extracellular Na ions are influenced by C-terminal truncations. We deleted the last two (YY) or five (KESYY) residues in Xenopus laevis alpha1 Na/K pumps made ouabain resistant by either of two kinds of point mutations and measured their currents as 10-mM ouabain-sensitive currents in Xenopus oocytes after silencing endogenous Xenopus Na/K pumps with 1 microM ouabain. We found the low affinity inhibitory influence of extracellular Na on outward Na/K pump current at negative voltages to be impaired in all of the C-terminally truncated pumps. Correspondingly, voltage jump-induced transient charge movements that reflect pump interactions with extracellular Na ions were strongly shifted to more negative potentials; this signals a several-fold reduction of the apparent affinity for extracellular Na in the truncated pumps. Parallel lowering of Na affinity on both sides of the membrane argues that the C-terminal contacts provide important stabilization of the occluded E1P(Na3) conformation, regardless of the route of Na ion entry into the

  5. The rapid-onset dystonia parkinsonism mutation D923N of the Na+, K+-ATPase alpha3 isoform disrupts Na+ interaction at the third Na+ site.

    Science.gov (United States)

    Einholm, Anja Pernille; Toustrup-Jensen, Mads S; Holm, Rikke; Andersen, Jens Peter; Vilsen, Bente

    2010-08-20

    Rapid-onset dystonia parkinsonism (RDP), a rare neurological disorder, is caused by mutation of the neuron-specific alpha3-isoform of Na(+), K(+)-ATPase. Here, we present the functional consequences of RDP mutation D923N. Relative to the wild type, the mutant exhibits a remarkable approximately 200-fold reduction of Na(+) affinity for activation of phosphorylation from ATP, reflecting a defective interaction of the E(1) form with intracellular Na(+). This is the largest effect on Na(+) affinity reported so far for any Na(+), K(+)-ATPase mutant. D923N also affects the interaction with extracellular Na(+) normally driving the E(1)P to E(2)P conformational transition backward. However, no impairment of K(+) binding was observed for D923N, leading to the conclusion that Asp(923) is specifically associated with the third Na(+) site that is selective toward Na(+). The crystal structure of the Na(+), K(+)-ATPase in E(2) form shows that Asp(923) is located in the cytoplasmic half of transmembrane helix M8 inside a putative transport channel, which is lined by residues from the transmembrane helices M5, M7, M8, and M10 and capped by the C terminus, recently found involved in recognition of the third Na(+) ion. Structural modeling of the E(1) form of Na(+), K(+)-ATPase based on the Ca(2+)-ATPase crystal structure is consistent with the hypothesis that Asp(923) contributes to a site binding the third Na(+) ion. These results in conjunction with our previous findings with other RDP mutants suggest that a selective defect in the handling of Na(+) may be a general feature of the RDP disorder.

  6. Urgências reprodutivas na cadela

    OpenAIRE

    Costa, Teresa Isabel Rodrigues da

    2010-01-01

    Dissertação de Mestrado Integrado em Medicina Veterinária As urgências reprodutivas ocorrem com frequência na prática clínica, estando o seu desfecho favorável associado a um diagnóstico e intervenção céleres. Na cadela, consideram-se urgências reprodutivas a distócia, a piómetra, o prolapso uterino, a torção uterina, a tetania puerperal, a metrite e a mastite. Esta dissertação tem por base a análise dos dados referentes à casuística de urgências reprodutivas em cadelas veri...

  7. Jogos teatrais na escola pública

    Directory of Open Access Journals (Sweden)

    Ricardo Ottoni Vaz Japiassu

    1998-07-01

    Full Text Available O artigo apresenta os resultados parciais de pesquisa etnográfica que acompanha aspectos do desenvolvimento cultural de pré-adolescentes com a linguagem teatral em classe multisseriada, através do ensino regular de Teatro, em escola de ensino fundamental da rede pública estadual de São Paulo-SP. Os dados obtidos permitem afirmar que a linguagem cênica contribui na conscientização das novas possibilidades de significação da palavra na prática discursiva.The article shows partial results of ethnographic research in which kids are observed in their cultural development process with theater classes in public school education in São Paulo/Brazil. The data colected indicates that the use of theater games in school education helps students to be aware of a word’s new meaning possibilities in human comunication.

  8. HUME E O EMPIRISMO NA MORAL

    Directory of Open Access Journals (Sweden)

    Adriano Naves de Brito

    2007-12-01

    Full Text Available O que pretendo defender neste texto é que uma posição empirista na moral é compatível com uma pretensão de validade intersubjetiva de juízos morais. Essa pretensão deve, nesse caso, estar calcada na naturalização dos fundamentos da moralidade, mas tem de conviver com limites acerca da justificação de enunciados de valor. Para defender esse ponto, sirvo-me da filosofia moral de Hume, como ele a expôs no seu texto Uma investigação sobre os princípios da moral. No que diz respeito à filosofia de Hume, o objetivo deste texto é explicitar o caráter empírico seja de seu método de investigação da moral, seja do princípio que para ela ele encontra.

  9. News from the NA61/SHINE experiment

    Science.gov (United States)

    Šuša, Tatjana

    2018-02-01

    The main goals of the NA61/SHINE experiment at the CERN SPS are the search for the critical point of strongly interacting matter and the study of the properties of the onset of deconfinement. These aims are pursued by performing a two-dimensional scan of the phase diagram of strongly interacting matter by varying the momentum and size of the colliding nuclei. This contribution summarises the latest results from the NA61/SHINE experiment, in particular, new results on spectra and yields of ϕ meson in p+p interactions at 40, 80 and 158 GeV/c and K+ and K- production in central Be+Be collisions at mid-rapidity. In addition, results on system size dependence of particle yield ratios and fluctuations are presented.

  10. NA62 experiment at CERN SPS

    Directory of Open Access Journals (Sweden)

    Kozhuharov Venelin

    2014-01-01

    Full Text Available The NA62 experiment at SPS is a continuation of the long standing CERN kaon physics program. The high statistics and the unprecedent precision allow to probe the Standard Model and test the description of the strong interactions at low energy. The final results on the the lepton universality test by measuring the ratio RK = Γ(K+ → e+ν/Γ(K+ → µ+ν and the study of the K± → π±γγ decay are presented. The major goal of the NA62 experiment is to perform a measurement of the Br(K+ → π+νν̄ with a precision of 10% in two years of data taking. The detector setup together with the analysis technique is described.

  11. Luz e tempo na melancolia I

    Directory of Open Access Journals (Sweden)

    Cláudio Soares Braga Furtado

    2009-12-01

    Full Text Available A comparação entre as artes possibilita figurar o tempo como elemento comum entre a gravura renascentista de Dürer, a escultura romana de Laocoonte e o conto de Guimarães Rosa. A partir da leitura dessas artes distantes em forma, meios, época e lugar, descobrem-se mistérios aludidos em sutis sinais, que, se ainda não despertos na consciência criativa, estimulam interpretações. O papel da luz como unificadora das entidades tempo/espaço restabelece o princípio clássico da ut pictura poesis na leitura moderna.

  12. Kaizen: Uma Metodologia Inovadora na Siderurgia

    Directory of Open Access Journals (Sweden)

    Hericson Estanislau Prata

    2017-04-01

    Full Text Available A racionalização do processo produtivo industrial, por meio da redução dos desperdícios e da modernização do processo produtivo, com a adoção do Sistema Toyota de Produção (Produção Enxuta, tem sido adotada por uma parte importante das indústrias no mundo. O objetivo deste artigo é descrever essa metodologia empregada pelo grupo de melhoria de fase intensiva adotado na Vallourec Tubos do Brasil S.A. Como resultado, verificou-se que o processo utilizado para a implantação de mudanças em curto prazo foi a semana intensiva, também conhecida como evento Kaizen na indústria automotiva.

  13. O Personal Trainer na Perspectiva do Marketing

    Directory of Open Access Journals (Sweden)

    Cibele Biehl Bossle

    2011-03-01

    Full Text Available Esse estudo apresenta mapeamento das referências dedicadas à formação do personal trainer em bases de dados eletrônicas. Essa garimpagem revelou baixa produção científica sobre o assunto e mostrou que na literatura sobre personal trainer predominam livros com linguagem corrente no mundo dos negócios. Esses achados nos levaram a indagar sobre a força do discurso físico-empresarial, especialmente o marketing, na constituição desta ocupação profissional. Jeremy Rifkin, Zygmunt Bauman, Paula Sibilia e Denise Sant'Anna permitiram visualizar que o marketing dirigido ao personal trainer tem como tarefa reinventar, ressignificar e "repaginar" esta modalidade de serviço em nome da sobrevivência no disputado mercado da vida ativa.

  14. New NA22 results on correlations

    International Nuclear Information System (INIS)

    De Wolf, E.A.

    1993-01-01

    Recent NA22 results from π + p and K + p inelastic interactions at √s = 22 GeV on invariant-mass and Q 2 -dependence of two- and three-particle factorial cumulants are discussed in relation to earlier intermittency studies. The absence of Bose-Einstein type correlations among identical particles, and too large resonance production rates, are responsible for the strong disagreements of models with intermittency data. 6 figs., 17 refs

  15. NA35: sulphur-gold collision

    CERN Multimedia

    1991-01-01

    In this image the real particles produced by the collision of a 6400 GeV sulphur ion with a gold target can be seen as they pass through a streamer chamber. Streamer chambers consist of a gas chamber through which a strong pulsed electric field is passed, creating sparks as a charged particle passes through it. The NA35 experiment, which was in operation in the 1980s, was part of CERN's ongoing heavy ion project.

  16. Die Calvinistiese Sondagbeskouing met spesiale verwysing na ...

    African Journals Online (AJOL)

    omver te werp. Aan die ander kant het die orde en vrede in die kerk dit wel ook nodig gemaak om 'n dag vir gebruik van die diens van die Here af te sonder. Calvyn se insigte in verband met die oorgang van die Sabbat na die Sondag, is die insigte wat as die eg reformatoriese behoue gebly het. Haitjema (1961:249) sê in.

  17. Sources of Na for the Io atmosphere

    Science.gov (United States)

    Burnett, D. S.; Ellis, Susan B.; Rice, A.; Epstein, S.

    1993-01-01

    The physics and geology of Io have been extensively studied, but there has been little discussion of the chemistry. Relatively little is known about Io chemistry, but there are constraints. Further, it will be a long time before improvements will result from direct observation, given the severe difficulties with the Galileo mission. Via laboratory simulation experiments, plausible thermochemical and photochemical processes which determine the nature and amounts of surface constituents of Io are explored. The well-known density of Io shows that the planet overall is rocky. Because the orbit of Io is well within the magnetosphere of Jupiter and because Io only has a thin, transient SO2 atmosphere, the surface is continually sputtered with magnetospheric ions. Complex processes ionize and accelerate the Io surface atoms to keV and MeV energies. Remarkably, only S, O, and Na ions were found by Voyager. Sputtering also produces an atomic cloud of Na and S (O not observable) with a trace of K. Both gaseous and solid SO2 are known from spectroscopic studies. A trace of H2S and possibly CO2 are present. Geologic features are interpreted in terms of elemental S, but there is no direct evidence for this constituent. We thus have a rocky planet which does not have rocks on the surface. Our general goal is to understand the cycling of Na, S, and O through the crust and atmosphere on present-day Io and to understand how Io evolved to this state. A specific objective was to determine the phases on the surface which are the source of the Na in the atmosphere of Io.

  18. The NA48 liquid krypton calorimeter

    CERN Document Server

    Gorini, B

    1997-01-01

    The NA48 collaboration goal is to measure the CP violation parameter Re(ɛl/ɛ) at the level of 2 × 10−4. The neutral Kaon decays will be reconstructed by an electromagnetic liquid Krypton calorimeter with fine granularity and a volume almost totally sensible, to obtain excellent position and energy resolution, as well as time resolution. A description of the detector, results from tests of a prototype and the status of the final calorimeter are reported.

  19. Prototype calorimeters for the NA3 experiment

    CERN Multimedia

    1975-01-01

    The NA3 Experiment was set-up on the North Area of the SPS by the CERN/ Ecole Polytechnique/College de France/ Orsay/Saclay Collaboration, to study high transverse momentum leptons and hadrons from hadron collisions. The calorimeters measured the energy of hadrons (prototype on the right) and leptons (prototype on the left). They used a new type of plastic scintillator (plexipop). (see CERN Courier of November 1975) energy (prototype on the right)

  20. Maendeleo ya Fasihi ya Kiswahili ya Watoto nchini Tanzania na ...

    African Journals Online (AJOL)

    Fasihi ya Kiswahili ya watoto kama taaluma haina muda mrefu katika historia ya fasihi ya Kiswahili. Ikilinganishwa na fasihi ya watu wazima ambayo ilianza muda mrefu, na pia tafiti nyingi kufanyika katika mataifa mengi, fasihi ya watoto inaonekana kuwa imetelekezwa kwa muda mrefu kutokana na kutokupewa umuhimu ...

  1. Dhima za Mbinu Linganishi katika Kuhusisha Lugha na Lahaja ...

    African Journals Online (AJOL)

    Lengo la makala hii ni kujadili dhima za Mbinu Linganishi katika kuhusisha lugha na lahaja. Data za makala hii zilikusanywa kwa kutumia mbinu mbalimbali ambazo ni usaili, ushuhudiaji, hojaji na majadiliano katika majopo. Utafiti ulifanyika Tanzania Bara hususan Mkoani Mtwara na Tanzania Visiwani katika maeneo ya ...

  2. Glial Na(+) -dependent ion transporters in pathophysiological conditions.

    Science.gov (United States)

    Boscia, Francesca; Begum, Gulnaz; Pignataro, Giuseppe; Sirabella, Rossana; Cuomo, Ornella; Casamassa, Antonella; Sun, Dandan; Annunziato, Lucio

    2016-10-01

    Sodium dynamics are essential for regulating functional processes in glial cells. Indeed, glial Na(+) signaling influences and regulates important glial activities, and plays a role in neuron-glia interaction under physiological conditions or in response to injury of the central nervous system (CNS). Emerging studies indicate that Na(+) pumps and Na(+) -dependent ion transporters in astrocytes, microglia, and oligodendrocytes regulate Na(+) homeostasis and play a fundamental role in modulating glial activities in neurological diseases. In this review, we first briefly introduced the emerging roles of each glial cell type in the pathophysiology of cerebral ischemia, Alzheimer's disease, epilepsy, Parkinson's disease, Amyotrophic Lateral Sclerosis, and myelin diseases. Then, we discussed the current knowledge on the main roles played by the different glial Na(+) -dependent ion transporters, including Na(+) /K(+) ATPase, Na(+) /Ca(2+) exchangers, Na(+) /H(+) exchangers, Na(+) -K(+) -Cl(-) cotransporters, and Na(+) - HCO3- cotransporter in the pathophysiology of the diverse CNS diseases. We highlighted their contributions in cell survival, synaptic pathology, gliotransmission, pH homeostasis, and their role in glial activation, migration, gliosis, inflammation, and tissue repair processes. Therefore, this review summarizes the foundation work for targeting Na(+) -dependent ion transporters in glia as a novel strategy to control important glial activities associated with Na(+) dynamics in different neurological disorders. GLIA 2016;64:1677-1697. © 2016 Wiley Periodicals, Inc.

  3. Muundo wa Mashairi katika Diwani ya Mnyampala (1965) na Nafasi ...

    African Journals Online (AJOL)

    Makala hii pia inadadisi namna mbinu za kimuundo zilivyofanikisha usawiri na ubainishaji wa falsafa ya mtunzi kuhusu ushairi wa Kiswahili na nafasi ya ushairi katika jamii. Makala imeanza kwa kugusia usuli wa historia ya ushairi wa Kiswahili, historia fupi ya maisha ya Mathias Mnyampala na nadharia yake kuhusu ...

  4. Ujitokezaji wa Viambishi Njeo na Athari zake Kifonolojia katika ...

    African Journals Online (AJOL)

    Chanzo cha data za utafiti huu ni vitabu mbalimbali vinavyohusu lugha ya Shimalila, navyo vimeandikwa na watu mbalimbali wa jamii ya Shimalila ambao malengo yao ni kutafsiri Biblia kutoka katika lugha ya Kiswahili kwenda katika lugha ya Shimalila. Pia, data nyingine zimetokana na hojaji pamoja na usaili wa moja ...

  5. BAKITA NA LUGHA YA KUFUNDISHIA | BAKITA | Kioo cha Lugha

    African Journals Online (AJOL)

    BAKITA NA LUGHA YA KUFUNDISHIA. Baraza la Kiswahili la Taifa BAKITA. Abstract. Makala haya yanatoa maelezo mafupi ya matukio muhimu kuhusu suala la kutumia Kiswahili kama lugha ya kufundishia sekondari na vyuo katika kipindi baina ya mwaka 1967 mpaka 2000. Makala yanaeleza dhima na shughuli za ...

  6. Hadhi ya Kiswahili na watumiaji wake katika utandawazi ...

    African Journals Online (AJOL)

    Katika Taifa la Tanzania, mathalani, Kiswahili kimewakusanya na kuwajumuisha pamoja watu wa makabila zaidi ya 150 – kikitumika kama lugha ya mawasiliano inayoeleweka na watu wote. Hii si ajabu, ikizingatiwa kuwa, kwa silika yake, Kiswahili ni lugha unganishi, yaani yenye hulka ya kuunganisha, na siyo ya ...

  7. Hydrophilic C terminus of Salicornia europaea vacuolar Na/H ...

    Indian Academy of Sciences (India)

    Plant vacuolar Na+/H+ antiporters play important roles in cellular ion homeostasis,vacuolar pH regulation and sequestration of Na+ ions into the vacuole. Previous research showed that hydrophilic C-terminal region of Arabidopsis AtNHX1 negatively regulates the Na+/H+ transporting activity. In this study, we truncated the ...

  8. Fanfiction: uma escrita criativa na web

    Directory of Open Access Journals (Sweden)

    Daniele Alves Alencar

    Full Text Available RESUMO Estudo das fanfictions como uma prática de incentivo à leitura e produção de textos ficcionais na web. Por meio de pesquisa exploratória, bibliográfica e qualitativa foi desenvolvido o assunto para a área daCiência da Informação. Utiliza o site “Nyah! Fanfiction” como fonte de informação sobre as fanfictions e para aplicação de questionáriocomo auxílio na investigação do comportamento dos fanfiqueiros do site. O artigo mostra o que são as fanfictions, descreve a forma diferenciada que o ficwriterl ê o texto original para a produção da história, e apresenta o site “Nyah! Fanfiction” não apenas como depositário de fanfictions, mas também informa como essa prática pode se tornar mais que um passatempo, por explorar a imaginação, estimular a criação de textos, e assim intensificar a prática de leitura e escrita entre os jovens. O assunto estudado ainda é considerado novo na área de Biblioteconomia, portanto se faz necessário o desenvolvimento de mais pesquisas abordando o tema fanfiction.

  9. Cultura Política na Antiguidade

    Directory of Open Access Journals (Sweden)

    José Petrúcio Farias Júnior

    2009-06-01

    Full Text Available

    Pretendemos discutir nesse artigo algumas implicações do termo cultura política na Antiguidade, especificamente, na sociedade romana imperial. Dessa forma, acreditamos que as considerações que apresentaremos a seguir contribuam para reflexão da utilização desse termo, produto das investigações contemporâneas, sobre os estudos das sociedades antigas. Para a historiadora Profa. Dra. Margarida Maria de Carvalho, tais reflexões representam ainda uma lacuna na historiografia concernente a essa temática. Isso posto, discorreremos, inicialmente, sobre o conceito de cultura e seus desdobramentos para, em seguida, refletirmos sobre o viés interpretativo que fundamenta estudos históricos que se desenvolvem sob o beneplácito da linha de pesquisa intitulada História e Cultura Política.

  10. NaI(Tl) response functions

    International Nuclear Information System (INIS)

    Vega C, H. R.; Ortiz R, J. M.; Benites R, J. L.; De Leon M, H. A.

    2015-09-01

    The response functions of a NaI(Tl) detector have been estimated using Monte Carlo methods. Response functions were calculated for monoenergetic photon sources (0.05 to 3 MeV). Responses were calculated for point-like sources and for sources distributed in Portland cement cylinders. The responses were used to calculate the efficiency functions in term of photon energy. Commonly, sources used for calibration are point-like, and eventually sources to be measured have different features. In order to use the calibrated sources corrections due to solid angle, self-absorption and scattering, must be carried out. However, some of these corrections are not easy to perform. In this work, the calculated responses were used to estimate the detector efficiency of point-like sources, and sources distributed in Portland type cement. Samples of Portland paste were prepared and were exposed to photoneutrons produced by a 15 MV linac. Some of the elements in the cement were activated producing γ-emitting radionuclides that were measured with a NaI(Tl) gamma-ray spectrometer, that was calibrated with point-like sources. In order to determine the specific activity in the induced radioisotopes calculated efficiencies were used to make corrections due to the differences between the solid angle, photon absorption and photon scattering in the point-like calibration sources and the sources distributed in cement. During the interaction between photoneutrons and the cement samples three radioisotopes were induced: 56 Mn, 24 Na, and 28 Al. (Author)

  11. A CPL NA SOCIEDADE DO CONHECIMENTO

    Directory of Open Access Journals (Sweden)

    Patrisia Ciancio

    2009-07-01

    online tem sido pensada pela Comunidade dos Países de Língua Portuguesa (CPLP, que registra preocupação com sua entrada na sociedade do conhecimento nas atas das reuniões de chefes de Estado, e seus desdobramentos, ocorridas a cada dois anos. No entanto, faltam projetos concretos a esta proposta. O enquadramento teórico da pesquisa que se apresenta está no terreno flutuante da Lusofonia, que em sua descontinuidade territorial e fragmentação se projeta em alternativas “tecnoculturais”. As missões colonizadoras pontilharam um trajeto invisível. Esfera que, de algum modo, persiste e pode ser restaurada na criação de comunidades virtuais com uso de novas tecnologias para refazer este percurso, agora em concepção inversa, que privilegia o mosaico cultural dos povos. Um círculo virtual que pede por ser também virtuoso. O objetivo é delimitar bases para uma proposta prática de criação de novos canais de interação. Para alcançar tais constatações, a metodologia empregada foi uma análise documental que verifica os debates ao redor da comunicação ao longo de dez anos (1996 a 2006 na CPLP.

  12. NA64 Search for Dark Photons

    CERN Document Server

    Shiakas, Christos

    2017-01-01

    The NA64 experiment, known as P348 before official approval, was proposed to the CERN SPSC on January 2014 with main goal the search for the following decay modes A′ → invisible A′ → e−e+ (1) In March 2016 P348 was granted approval by the CERN Research Board and received the title NA64. Since having been promoted, the experiment has been conducting the searches the searches for the processes mentioned above at the CERN SPS. NA64 is a fixed target experiment which utilizes the active beam dump. The detection of rare processes is based on the missing energy techniques. Such techniques are used for particles whose interaction with the detector is very small, so that they escape the detection and carry away some energy. A significant missing energy in the experiment means that such particles are produced. The method of the search for the A′ → invisible decay is as follows. If the A′ exists it could be produced via the kinetic mixing with bremsstrahlung photons in the reaction of high-energy elec...

  13. Imunossupressores na Dermatologia Immunosuppressive agents in Dermatology

    Directory of Open Access Journals (Sweden)

    Aline Lopes Bressan

    2010-02-01

    Full Text Available Os imunossupressores são drogas que agem na divisão celular e têm propriedades anti-inflamatórias. Sendo assim, são essencialmente prescritos na prevenção de rejeição de transplantes e no tratamento das doenças autoimunes e inflamatórias crônicas, que, na Dermatologia, têm a psoríase como maior representante. Nesta sessão serão descritas as principais drogas imunossupressoras, com orientações para seu manejo adequado.Immunosupressants are drugs that act in cell division and have anti-inflammatory effects. Therefore, they are essentially prescribed in the prevention of transplant rejection and in the treatment of autoimmune disorders and chronic inflammatory diseases, whose main example in Dermatology is psoriasis. In this work the most important immunosuppressive drugs and orientation to properly administer them are going to be described.

  14. Resonances production from the NA60 experiment

    Directory of Open Access Journals (Sweden)

    De Falco A.

    2012-11-01

    Full Text Available The NA60 experiment at the CERN SPS has studied light vector meson production in In-In collisions at 158A GeV. The ϕ meson was detected via both the K+K− and the μ+μ− decay channels. The yields and inverse slope parameters of the mT spectra observed in the two channels are compatible within errors, different from the large discrepancies seen in Pb-Pb collisions between the hadronic (NA49 and dimuon (NA50 decay channels. In the invariant mass region 0.2 1 GeV, the excess is found to be prompt, with remarkable differences with respect to the Drell-Yan process. The Teff slope parameter, extracted from the transverse mass spectra, shows a rise with mass up to the ρ, followed by a sudden decline for higher masses. The former is consistent with radial flow of a hadronic source, while the latter suggests a dominantly partonic emission source.

  15. Envolvimento do sistema nervoso central na cisticercose

    Directory of Open Access Journals (Sweden)

    Aristides Cheto de Queiroz

    1979-03-01

    Full Text Available No estudo do envolvimento do SNC na cisticercose, verificou-se uma freqüência de 0,3%, sempre como achado incidental no estudo de rotina de autópsias; apenas um caso mostrou boa correlação com a presença de manifestações neurológicas. Esta freqüência que é baixa em relação ao que é observado em outras regiões do Brasil, mostra que a neurocisticercose não representa um grande problema na região. As reações do hospedeiro ao embrião do cisticerco foram sempre do tipo inflamatório crônico e fibrosante. Neste estudo ficou demonstrada a importância do método de impregnação pela prata (Grocott na identificação do esqueleto do cisticerco no interior de lesões fibrosantes e/ou calcificadas.

  16. Growth mechanism of NaClO 3 and NaBrO 3 crystals from aqueous ...

    Indian Academy of Sciences (India)

    A study of growth rates of NaClO3 and NaBrO3 has been carried out using a small growth cell by in situ observation. Normal growth rates of {100} faces of NaClO3 and {111} faces of NaBrO3 along ⟨ 110 ⟩ direction are measured under relatively high supersaturation ranging from 3–8%. In the initial stages of growth, {100}, ...

  17. Growth mechanism of NaClO3 and NaBrO3 crystals from aqueous ...

    Indian Academy of Sciences (India)

    A study of growth rates of NaClO3 and NaBrO3 has been carried out using a small growth cell by in situ observation. Normal growth rates of {100} faces of NaClO3 and {111} faces of NaBrO3 along ⟨ 110 ⟩ direction are measured under relatively high supersaturation ranging from 3–8%. In the initial stages of growth, {100}, ...

  18. Route, mechanism, and implications of proton import during Na+/K+ exchange by native Na+/K+-ATPase pumps.

    Science.gov (United States)

    Vedovato, Natascia; Gadsby, David C

    2014-04-01

    A single Na(+)/K(+)-ATPase pumps three Na(+) outwards and two K(+) inwards by alternately exposing ion-binding sites to opposite sides of the membrane in a conformational sequence coupled to pump autophosphorylation from ATP and auto-dephosphorylation. The larger flow of Na(+) than K(+) generates outward current across the cell membrane. Less well understood is the ability of Na(+)/K(+) pumps to generate an inward current of protons. Originally noted in pumps deprived of external K(+) and Na(+) ions, as inward current at negative membrane potentials that becomes amplified when external pH is lowered, this proton current is generally viewed as an artifact of those unnatural conditions. We demonstrate here that this inward current also flows at physiological K(+) and Na(+) concentrations. We show that protons exploit ready reversibility of conformational changes associated with extracellular Na(+) release from phosphorylated Na(+)/K(+) pumps. Reversal of a subset of these transitions allows an extracellular proton to bind an acidic side chain and to be subsequently released to the cytoplasm. This back-step of phosphorylated Na(+)/K(+) pumps that enables proton import is not required for completion of the 3 Na(+)/2 K(+) transport cycle. However, the back-step occurs readily during Na(+)/K(+) transport when external K(+) ion binding and occlusion are delayed, and it occurs more frequently when lowered extracellular pH raises the probability of protonation of the externally accessible carboxylate side chain. The proton route passes through the Na(+)-selective binding site III and is distinct from the principal pathway traversed by the majority of transported Na(+) and K(+) ions that passes through binding site II. The inferred occurrence of Na(+)/K(+) exchange and H(+) import during the same conformational cycle of a single molecule identifies the Na(+)/K(+) pump as a hybrid transporter. Whether Na(+)/K(+) pump-mediated proton inflow may have any physiological or

  19. Route, mechanism, and implications of proton import during Na+/K+ exchange by native Na+/K+-ATPase pumps

    Science.gov (United States)

    Vedovato, Natascia

    2014-01-01

    A single Na+/K+-ATPase pumps three Na+ outwards and two K+ inwards by alternately exposing ion-binding sites to opposite sides of the membrane in a conformational sequence coupled to pump autophosphorylation from ATP and auto-dephosphorylation. The larger flow of Na+ than K+ generates outward current across the cell membrane. Less well understood is the ability of Na+/K+ pumps to generate an inward current of protons. Originally noted in pumps deprived of external K+ and Na+ ions, as inward current at negative membrane potentials that becomes amplified when external pH is lowered, this proton current is generally viewed as an artifact of those unnatural conditions. We demonstrate here that this inward current also flows at physiological K+ and Na+ concentrations. We show that protons exploit ready reversibility of conformational changes associated with extracellular Na+ release from phosphorylated Na+/K+ pumps. Reversal of a subset of these transitions allows an extracellular proton to bind an acidic side chain and to be subsequently released to the cytoplasm. This back-step of phosphorylated Na+/K+ pumps that enables proton import is not required for completion of the 3 Na+/2 K+ transport cycle. However, the back-step occurs readily during Na+/K+ transport when external K+ ion binding and occlusion are delayed, and it occurs more frequently when lowered extracellular pH raises the probability of protonation of the externally accessible carboxylate side chain. The proton route passes through the Na+-selective binding site III and is distinct from the principal pathway traversed by the majority of transported Na+ and K+ ions that passes through binding site II. The inferred occurrence of Na+/K+ exchange and H+ import during the same conformational cycle of a single molecule identifies the Na+/K+ pump as a hybrid transporter. Whether Na+/K+ pump–mediated proton inflow may have any physiological or pathophysiological significance remains to be clarified. PMID

  20. VISIBILIDADE GAY NA ESCOLA: ESTUDANTES QUEER

    Directory of Open Access Journals (Sweden)

    Aline Ferraz da Silva

    2008-03-01

    Full Text Available Nesse artigo apresento as considerações e análises presentes na pesquisa em processo, que realizo numa escola pública. Sua constituição deve seu primeiro movimento às manifestações de desconforto e homofobia com relação a um grupo específico de três estudantes gays na comunidade escolar na qual atuo como professora. Percebo que a presença desse grupo desacomoda o cotidiano escolar e desenvolvo minha argumentação com base no potencial desestabilizador desses sujeitos, na intenção de pensar o impensável no currículo escolar. Esse trabalho parte da visibilidade de uma identidade sexual que foge à norma heterossexual e desafia a tendência normalizadora e homogeneizadora da educação. A maneira como esse grupo gay se posiciona e constrói seus corpos cruza as fronteiras do masculino/feminino, desnaturalizando as identidades sexuais e de gênero que se baseiam em características biológicas e se apresentando como diferença que escapa às classificações binárias. Na construção da pesquisa utilizo como referência o pensamento de Michel Foucault, especialmente com relação à construção histórica e discursiva de conceitos como sexualidade, identidade, diferença e normalidade que têm servido para criação e manutenção de padrões de conduta. Ao levar a problematização desses conceitos para o contexto escolar, considero produtiva a teorização queer para pensar a possibilidade de uma educação não heteronormativa, produtora de diferenças, que desconstrua identidades ao invés de tentar cristalizá-las.

  1. Response of saliva Na/K ratio to changing Na supply of lactating cows under tropical conditions

    NARCIS (Netherlands)

    Thiangtum, Wandee; Schonewille, J Thomas; Verstegen, Martin Wa; Arsawakulsudhi, Supot; Rukkwamsuk, Theera; Hendriks, Wouter H

    BACKGROUND: Factorial determination of the sodium (Na) requirement of heat-stressed lactating cows is hindered by accurate estimates of the Na losses through sweat. Direct studies, therefore, may be needed requiring information on the time course of healthy animals to become Na depleted and the

  2. Response of saliva Na/K ratio to changing Na supply of lactating cows under tropical conditions

    NARCIS (Netherlands)

    Thiangtum, Wandee; Schonewille, Thomas J.; Verstegen, Martin W.A.; Arsawakulsudhi, Supot; Rukkwamsuk, Theera; Hendriks, Wouter H.

    2017-01-01

    BACKGROUND: Factorial determination of the sodium (Na) requirement of heat-stressed lactating cows is hindered by accurate estimates of the Na losses through sweat. Direct studies, therefore, may be needed requiring information on the time course of healthy animals to become Na depleted and the

  3. Polarization and collision velocity dependence of associative ionization in cold Na (3p)-Na(3p) collisions

    NARCIS (Netherlands)

    Meijer, H.A.J.

    1990-01-01

    We studied the polarization dependence of the associative ionization (AI) process Na(3p) + Na(3p) → Na2+ at collision velocities between 100 and 700 m/s (5 and 200 K), using linearly and circularly polarized light for the excitation. We found that the polarization dependence varies strongly in the

  4. Irreversible block of cardiac mutant Na+ channels by batrachotoxin.

    Science.gov (United States)

    Wang, Sho-Ya; Tikhonov, Denis B; Mitchell, Jane; Zhorov, Boris S; Wang, Ging Kuo

    2007-01-01

    Batrachotoxin (BTX) not only keeps the voltage-gated Na(+) channel open persistently but also reduces its single-channel conductance. Although a BTX receptor has been delimited within the inner cavity of Na(+) channels, how Na(+) ions flow through the BTX-bound permeation pathway remains unclear. In this report we tested a hypothesis that Na(+) ions traverse a narrow gap between bound BTX and residue N927 at D2S6 of cardiac hNa(v)1.5 Na(+) channels. We found that BTX at 5 microM indeed elicited a strong block of hNa(v)1.5-N927K currents (approximately 70%) after 1000 repetitive pulses (+50 mV/20 ms at 2 Hz) without any effects on Na(+) channel gating. Once occurred, this unique use-dependent block of hNa(v)1.5-N927K Na(+) channels recovered little at holding potential (-140 mV), demonstrating that BTX block is irreversible under our experimental conditions. Such an irreversible effect likewise developed in fast inactivation-deficient hNa(v)1.5-N927K Na(+) channels albeit with a faster on-rate; approximately 90% of peak Na(+) currents were abolished by BTX after 200 repetitive pulses (+50 mV/20 ms). This use-dependent block of fast inactivation-deficient hNa(v)1.5-N927K Na(+) channels by BTX was duration dependent. The longer the pulse duration the larger the block developed. Among N927K/W/R/H/D/S/Q/G/E substitutions in fast inactivation-deficient hNa(v)1.5 Na(+) channels, only N927K/R Na(+) currents were highly sensitive to BTX block. We conclude that (a) BTX binds within the inner cavity and partly occludes the permeation pathway and (b) residue hNa(v)1.5-N927 is critical for ion permeation between bound BTX and D2S6, probably because the side-chain of N927 helps coordinate permeating Na(+) ions.

  5. MOBILNO POSLOVANJE NA PRIMERU UPORABE MICROSOFT DYNAMICS CRM

    OpenAIRE

    Duh, Tamara

    2016-01-01

    Hitro razvijajoči se svet nas spodbuja k hitremu reagiranju na novosti, ki se pojavljajo na trgu. Prav zaradi tega je danes zelo pomembno upravljati z mobilnimi napravami, da se lahko hitro in brez težav soočimo z morebitnimi težavami oz. zagatami. Prav iz tega razloga je mobilno poslovanje ena izmed inovativnih rešitev, ki ljudem omogoča seznanjenost z informacijami na vsakem koraku in omogoča hiter odziv na spremembe. Prav ta rešitev omogoča podjetjem, da so konkurenčna in hkrati lahko hitr...

  6. Na+ channel function, regulation, structure, trafficking and sequestration

    Science.gov (United States)

    Chen-Izu, Ye; Shaw, Robin M; Pitt, Geoffrey S; Yarov-Yarovoy, Vladimir; Sack, Jon T; Abriel, Hugues; Aldrich, Richard W; Belardinelli, Luiz; Cannell, Mark B; Catterall, William A; Chazin, Walter J; Chiamvimonvat, Nipavan; Deschenes, Isabelle; Grandi, Eleonora; Hund, Thomas J; Izu, Leighton T; Maier, Lars S; Maltsev, Victor A; Marionneau, Celine; Mohler, Peter J; Rajamani, Sridharan; Rasmusson, Randall L; Sobie, Eric A; Clancy, Colleen E; Bers, Donald M

    2015-01-01

    This paper is the second of a series of three reviews published in this issue resulting from the University of California Davis Cardiovascular Symposium 2014: Systems approach to understanding cardiac excitation–contraction coupling and arrhythmias: Na+ channel and Na+ transport. The goal of the symposium was to bring together experts in the field to discuss points of consensus and controversy on the topic of sodium in the heart. The present review focuses on Na+ channel function and regulation, Na+ channel structure and function, and Na+ channel trafficking, sequestration and complexing. PMID:25772290

  7. Usando a antimatéria na medicina moderna

    OpenAIRE

    Machado,A.C.B.; Pleitez,V.; Tijero,M.C.

    2006-01-01

    Neste artigo, fazemos uma breve exposição de como um dos conceitos fundamentais da física moderna, a existência de antimatéria, tem aplicação na medicina, na chamada tomografia por emissão de pósitrons (PET na sigla em inglês). Ela consiste na produção de imagens tomográficas digitais do organismo que são obtidas pela detecção da radiação produzida na aniquilação do pósitron com o elétron.

  8. Novel regulation of cardiac Na pump via phospholemman.

    Science.gov (United States)

    Pavlovic, Davor; Fuller, William; Shattock, Michael J

    2013-08-01

    As the only quantitatively significant Na efflux pathway from cardiac cells, the Na/K ATPase (Na pump) is the primary regulator of intracellular Na. The transmembrane Na gradient it establishes is essential for normal electrical excitability, numerous coupled-transport processes and, as the driving force for Na/Ca exchange, thus setting cardiac Ca load and contractility. As Na influx varies with electrical excitation, heart rate and pathology, the dynamic regulation of Na efflux is essential. It is now widely recognized that phospholemman, a 72 amino acid accessory protein which forms part of the Na pump complex, is the key nexus linking cellular signaling to pump regulation. Phospholemman is the target of a variety of post-translational modifications (including phosphorylation, palmitoylation and glutathionation) and these can dynamically alter the activity of the Na pump. This review summarizes our current understanding of the multiple regulatory mechanisms that converge on phospholemman and govern NA pump activity in the heart. The corrected Fig. 4 is reproduced below. The publisher would like to apologize for any inconvenience caused. [corrected]. Copyright © 2013. Published by Elsevier Ltd.

  9. Synthesis of Na-A and/or Na-X zeolite/porous carbon composites from carbonized rice husk

    International Nuclear Information System (INIS)

    Katsuki, Hiroaki; Komarneni, Sridhar

    2009-01-01

    Na-A and/or Na-X zeolite/porous carbon composites were prepared under hydrothermal conditions by NaOH dissolution of silica first from carbonized rice husk followed by addition of NaAlO 2 and in situ crystallization of zeolites i.e., using a two-step process. When a one-step process was used, both Na-A and Na-X zeolites crystallized on the surface of carbon. Na-A or Na-X zeolite crystals were prepared on the porous carbonized rice husk at 90 deg. C for 2-6 h by changing the SiO 2 /Al 2 O 3 , H 2 O/Na 2 O and Na 2 O/SiO 2 molar ratios of precursors in the two-step process. The surface area and NH 4 + -cation exchange capacity (CEC) of Na-A zeolite/porous carbon were found to be 171 m 2 /g and 506 meq/100 g, respectively, while those of Na-X zeolite/porous carbon composites were 676 m 2 /g and 317 meq/100 g, respectively. Na-A and Na-X zeolites are well-known microporous and hydrophilic materials while carbonized rice husk was found to be mesoporous (pores of ∼3.9 nm) and hydrophobic. These hybrid microporous-mesoporous and hydrophilic-hydrophobic composites are expected to be useful for decontamination of metal cations as well as organic contaminants simultaneously. - Graphical Abstract: Novel Na-X zeolite/porous carbon composite.

  10. Synthesis of zeolites Na-A and Na-X from tablet compressed and calcinated coal fly ash

    Science.gov (United States)

    Hu, Tao; Gao, Wenyan; Liu, Xin; Zhang, Yifu; Meng, Changgong

    2017-10-01

    Zeolites Na-A and Na-X are important synthetic zeolites widely used for separation and adsorption in industry. It is of great significance to develop energy-efficient routines that can synthesize zeolites Na-A and Na-X from low-cost raw materials. Coal fly ash (CFA) is the major residue from the combustion of coal and biomass containing more than 85% SiO2 and Al2O3, which can readily replace the conventionally used sodium silicate and aluminate for zeolite synthesis. We used Na2CO3 to replace the expensive NaOH used for the calcination of CFA and showed that tablet compression can enhance the contact with Na2CO3 for the activation of CFA through calcination for the synthesis of zeolites Na-A and Na-X under mild conditions. We optimized the control variables for zeolite synthesis and showed that phase-pure zeolite Na-A can be synthesized with CFA at reactant molar ratio, hydrothermal reaction temperature and reaction time of 1.3Na2O: 0.6Al2O3: 1SiO2: 38H2O at 80°C for 6 h, respectively, while phase-pure zeolite Na-X can be synthesized at 2.2Na2O: 0.2Al2O3: 1SiO2: 88H2O at 100°C for 8 h, respectively. The composition, morphology, specific surface area, vibration spectrum and thermogravimetry of synthesized Na-A and Na-X were further characterized.

  11. Identidade, nação e território na escrita dos intelectuais Mapuches

    Directory of Open Access Journals (Sweden)

    Claudia Zapata Silva

    2007-12-01

    Full Text Available Este artigo tem por objetivo dar conta de um novo sujeito indígena, surgido na segunda metade do século XX: o intelectual indígena contemporâneo, formado em instituições de educação superior e que constrói discursos e representações a partir de uma disciplina do conhecimento (História, Sociologia, Literatura, Antropologia, entre outras. Abordarse- á o caso particular dos intelectuais mapuches na década de noventa, a partir de uma perspectiva de análise que os considera como autores e como atores de contornos próprios no interior do que, na atualidade, se conhece como Movimento Mapuche.

  12. Erythrocyte Na+/K+ ATPase activity measured with sup 23 Na NMR

    Energy Technology Data Exchange (ETDEWEB)

    Ouwerkerk, R.; van Echteld, C.J.; Staal, G.E.; Rijksen, G. (University Hospital, Utrecht (Netherland))

    1989-11-01

    A {sup 23}Na NMR assay for measurement of erythrocyte Na+/K+ ATPase activity is presented. Using the nonpermeant shift reagent dysprosium tripolyphosphate the signals of intra- and extracellular sodium are separated, enabling measurement of sodium fluxes nondestructively, without the need to physically separate the cells from their environment. By increasing membrane permeability with nystatin we have shown that the assay allows the detection of differences in membrane permeability. With low doses of nystatin the ouabain-sensitive sodium flux increased more than twofold. With high doses of nystatin the Na+/K+ pump could not prevent an almost total equilibration of intra- and extracellular sodium. All sodium that entered the cells remained NMR visible, proving that sodium influx can be measured quantitatively. {sup 31}P NMR spectra taken before and after the assay revealed a slight acidification of the cells and no significant change in ATP concentration. No evidence of Dy3+ entering the cell was observed.

  13. Benefícios da cafeína na terapêutica

    OpenAIRE

    Ribeiro, Célia Pereira

    2013-01-01

    Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz A cafeína é uma substância amplamente consumida, principalmente pelas suas propriedades estimulantes. Mas é também utilizada a nível terapêutico, e são cada vez mais os estudos que procuram aprofundar e conhecer novas aplicações terapêuticas da cafeína. Existe uma extensa literatura acerca do citrato de cafeína para o tratamento da apneia de recém-nascidos prematuros, e os estudos indicam q...

  14. Achados histeroscópicos em mulheres na pós-menopausa com diagnóstico de espessamento endometrial por ultra-sonografia transvaginal Hysteroscopic findings in postmenopausal women with endometrial thickening diagnosed by transvaginal ultrasound

    Directory of Open Access Journals (Sweden)

    Adriana Bittencourt Campaner

    2004-02-01

    Full Text Available OBJETIVO: correlacionar espessamento endometrial diagnosticado por ultra-sonografia com os achados histeroscópicos, em mulheres na pós-menopausa. MÉTODOS: foi realizado estudo transversal com avaliação histeroscópica em 121 mulheres na pós-menopausa, com diagnóstico de espessamento do endométrio por ultra-sonografia transvaginal. Das pacientes incluídas, 23 (19% recebiam diferentes esquemas de hormonioterapia e 98 não referiam uso de reposição hormnonal.; 55 pacientes queixavam-se de sangramento por via vaginal e as restantes apresentavam-se sem esta condição. Os exames endoscópicos foram realizados ambulatorialmente, utilizando-se histeroscópio rígido de 4 mm. Para a distensão da cavidade uterina empregou-se gás carbônico (CO2. Biópsia foi praticada em todas as pacientes, com auxílio de cureta tipo Novak, de 3 mm, e o material obtido submetido a estudo histopatológico. RESULTADOS: a espessura do endométrio variou entre 6 e 38 mm, com média de 10,7 ± 5,3 mm. Os achados histeroscópicos foram: lesão polipóide, em 51 pacientes (42,1%; endométrio atrófico, em 15 (12,4%; sinéquia senil, em 15 (12,4%; espessamento focal, em 13 (10,7%; lesão cerebróide, em 6 (5,0%; endométrio proliferativo, em 5 (4,1%; muco, em 5 (4,1%; mioma, em 4 (3,3%; endométrio secretor, em 3 (2,5%; hiperplasia endometrial, em 3 (2,5% e atrofia cística, em 1 (0,8%. Observou-se correlação entre os achados histeroscópicos e os resultados da histopatologia em 30 dos 51 casos de pólipo, em 12 dos 15 de endométrio atrófico e na totalidade dos casos sugestivos de hiperplasia endometrial e de adenocarcinoma. CONCLUSÃO: na maioria das pacientes, o exame histeroscópico revelou que não se tratava de real espessamento endometrial, mas sim de outras variedades de lesão da cavidade uterina.PURPOSE: to correlate endometrial thickening diagnosed by ultrasonography with hysteroscopic findings in postmenopausal women. METHODS: a transversal study

  15. Na+-K+ pump in chronic renal failure

    International Nuclear Information System (INIS)

    Deepak, K.; Kahn, T.

    1987-01-01

    This review summarizes the evidence for the defect in Na + -K + pump in chronic renal failure, considers the role of various factors in causing this defect, and discusses the clinical implications thereof. Intracellular Na is elevated in erythrocytes, leukocytes, and muscle cells from some patients with chronic renal failure (CRF). Recent evidence suggest that this elevation of cell Na may be, in large part, a consequence of decreased number of Na + -K + pump units per cell. Maintenance dialysis over a period of weeks ameliorates the defect in intracellular Na + , and this improvement is contemporaneous with an increase in the number of Na + -K + pump sites per cell. In erythrocytes with normal cell Na + , acute hemodialysis increases the rate of 22 Na + and 42 K + transport. Many factors such as the presence of retained toxic metabolite or circulating inhibitor in the uremic plasma, or biochemical changes produced by acute hemodialysis, may explain this finding. In cells with high cell Na + , the pump-mediated 42 K + transport is normalized at the expense of a raised cell Na + . The decreased muscle membrane potential in uremic subjects has been attributed to a decreased activity of Na + -K + pump. The authors discuss the role of hormonal abnormalities and circulating inhibitors, which may cause an acute inhibition of the pump and of other factors such as K + depletion, which may cause more chronic alterations. The implications of alteration of Na + and K + pump transport and raised cell Na + on other non-pump-mediated transport pathways are discussed. Raised cell Na + may be a marker for the adequacy of maintenance dialysis in patients with end-stage renal failure

  16. Study of π0 Dalitz decays in the NA62 and NA48/2 experiments

    Science.gov (United States)

    Maurice, E.; Ambrosino, F.; Antonelli, A.; Anzivino, G.; Arcidiacono, R.; Baldini, W.; Balev, S.; Bifani, S.; Biino, C.; Bizzeti, A.; Bloch-Devaux, B.; Bolotov, V.; Bucci, F.; Ceccucci, A.; Cenci, P.; Cerri, C.; Collazuol, G.; Costantini, F.; Cotta Ramusino, A.; Coward, D.; D'Agostini, G.; Dalpiaz, P.; Danielsson, H.; Dellacasa, G.; Di Filippo, D.; DiLella, L.; Doble, N.; Duk, V.; Engelfried, J.; Eppard, K.; Falaleev, V.; Fantechi, R.; Fiorini, M.; Frabetti, P. L.; Fucci, A.; Gallorini, S.; Gatignon, L.; Gersabeck, E.; Gianoli, A.; Giudici, S.; Goudzovski, E.; Goy Lopez, S.; Gushchin, E.; Hallgren, B.; Hita-Hochgesand, M.; Iacopini, E.; Imbergamo, E.; Kekelidze, V.; Kleinknecht, K.; Kozhuharov, V.; Kurshetsov, V.; Lamanna, G.; Lazzeroni, C.; Lenti, M.; Leonardi, E.; Litov, L.; Madigozhin, D.; Maier, A.; Mannelli, I.; Marchetto, F.; Massarotti, P.; Misheva, M.; Molokanova, N.; Moulson, M.; Movchan, S.; Napolitano, M.; Norton, A.; Numao, T.; Obraztsov, V.; Palladino, V.; Pepe, M.; Peters, A.; Petrucci, F.; Peyaud, B.; Piandani, R.; Piccini, M.; Pierazzini, G.; Popov, I.; Potrebenikov, Yu.; Raggi, M.; Renk, B.; Retière, F.; Riedler, P.; Romano, A.; Rubin, P.; Ruggiero, G.; Salamon, A.; Saracino, G.; Savrié, M.; Semenov, V.; Sergi, A.; Serra, M.; Shkarovskiy, S.; Sozzi, M.; Spadaro, T.; Valente, P.; Veltri, M.; Venditti, S.; Wahl, H.; Wanke, R.; Winhart, A.; Winston, R.; Yushchenko, O.; Zinchenko, A.; NA62 Collaboration; NA48/2 Collaboration

    2017-01-01

    The NA62 experiment at CERN collected a large sample of charged kaon decays with a highly efficient trigger for decays into electrons in 2007. The kaon beam represents a source of tagged neutral pion decays in vacuum. A measurement of the electromagnetic transition form factor slope of the neutral pion in the time-like region from ∼1 million fully reconstructed π0 Dalitz decay is presented. The limits on dark photon production in π0 decays from the earlier kaon experiment at CERN, NA48/2, are also reported.

  17. Fitoterápicos na odontologia: estudo etnobotânico na cidade de Manaus

    Directory of Open Access Journals (Sweden)

    S. S. Evangelista

    2013-01-01

    Full Text Available O reconhecimento oficial da fitoterapia na odontologia no Brasil veio acompanhado de diversas lacunas na pesquisa científica e na utilização de plantas medicinais, especificamente para espécies vegetais com aplicação nas doenças da cavidade oral. O estado do Amazonas, especificamente a cidade de Manaus, não possui um diagnóstico da aplicabilidade de plantas medicinais nos serviços de atenção Odontológica. Esse estudo propôs realizar um estudo do tipo quali-quantitativo, descritivo e exploratório visando o levantamento da comercialização de plantas medicinais e o estudo etnobotânico para identificação das principais plantas medicinais indicadas e utilizadas nas patologias orais nos atendimentos odontológicos ambulatoriais na cidade de Manaus. Foram entrevistados 197 usuários do serviço odontológico, 150 Cirurgiões-Dentistas, e 47 comerciantes credenciados na prefeitura Municipal de Manaus. A amostragem foi realizada por acessibilidade ou conveniência para os Cirurgiões-Dentistas, enquanto os usuários foram selecionados através de amostragem aleatória simples, e os comerciantes de plantas medicinais foram entrevistados em sua totalidade. Os resultados demonstraram a existência de comercialização de plantas medicinais para patologias orais, destacando-se as seguintes espécies: Pedra ume cãa (Aulomyrcia sphareocarpa, Crajiru (Arrabidae chica, além da planta, sem identificação botânica, conhecida popularmente como Sara tudo. Entre os Cirurgiões-Dentistas e entre os pacientes, apenas 8% e 7,61%, respectivamente, utilizaram plantas medicinais para alterações patológicas orais. Os autores concluíram que as plantas medicinais comercializadas na cidade de Manaus são utilizadas de maneira empírica e que, apesar da Política Nacional de Práticas Integrativas e Complementares (PNPIC, novas políticas públicas de saúde devem inserir plantas medicinais e fitoterápicos de uso oral na rede pública de saúde na

  18. OGLAŠEVANJE NA SOCIALNEM OMREŽJU FACEBOOK, NA PRIMERU SPLETICNA.SI

    OpenAIRE

    Reisman, Nina

    2011-01-01

    Internet je od svojega razvoja dolgo časa obstajal kot prostor za enostransko komunikacijo. Isto se je dogajalo na televiziji, radiu in časopisih, kjer je javnost sprejemala informacije, ki jih je nekdo pripravil. Tradicionalni mediji so hitro doumeli, da takšna vrsta komunikacije ni naravna in ne predstavlja najboljšega ohranjanja gledalcev in poslušalcev. Začela se je uporabljati dvosmerna komunikacija. Trenutno v svetu najbolje poznan primer dvosmerne komunikacije je socialno omrežje F...

  19. Načrtovanje izkoriščanja hidroenergije na primeru reke Mure

    OpenAIRE

    Madjar, Klaudija

    2016-01-01

    Reka Mura lahko kot neizkoriščen hidro potencial pripomore k zvišanju deleža energije iz obnovljivih virov. V diplomski nalogi je opisano izkoriščanje energije vode za pridobivanje električne energije, predstavljene pa so tudi obstoječe hidroelektrarne v Sloveniji. Nadalje so opisane hidrološke značilnosti reke Mure in ekosistemi ob njej. Načrtovane hidroelektrarne na reki Muri predstavljajo precejšen poseg v določeno območje, zato ga je pred realizacijo potrebno dobro proučiti. Izgradnja hid...

  20. Transtorno afetivo bipolar na infância e na adolescência

    OpenAIRE

    Fu-I,Lee

    2004-01-01

    Os conhecimentos sobre transtorno afetivo bipolar com início na infância e na adolescência têm avançado muito nos últimos 15 anos. Atualmente, os esforços estão dirigidos para investigar o quadro clínico, para o desenvolvimento de instrumentos que auxiliam diagnóstico precoce e investigações de melhores formas de tratamentos de crianças e adolescentes portadores do transtorno. O presente texto tem objetivo de apresentar as principais características clínicas do transtorno em crianças e adoles...

  1. NaI(Tl) response functions

    Energy Technology Data Exchange (ETDEWEB)

    Vega C, H. R.; Ortiz R, J. M. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas, Zac. (Mexico); Benites R, J. L. [Centro Estatal de Cancerologia de Nayarit, Calz. de la Cruz 118 Sur, Tepic, Nayarit (Mexico); De Leon M, H. A., E-mail: fermineutron@yahoo.com.mx [Instituto Tecnologico de Aguascalientes, Av. Adolfo Lopez Mateos 1801 Ote., 20155 Aguascalientes, Ags. (Mexico)

    2015-09-15

    The response functions of a NaI(Tl) detector have been estimated using Monte Carlo methods. Response functions were calculated for monoenergetic photon sources (0.05 to 3 MeV). Responses were calculated for point-like sources and for sources distributed in Portland cement cylinders. The responses were used to calculate the efficiency functions in term of photon energy. Commonly, sources used for calibration are point-like, and eventually sources to be measured have different features. In order to use the calibrated sources corrections due to solid angle, self-absorption and scattering, must be carried out. However, some of these corrections are not easy to perform. In this work, the calculated responses were used to estimate the detector efficiency of point-like sources, and sources distributed in Portland type cement. Samples of Portland paste were prepared and were exposed to photoneutrons produced by a 15 MV linac. Some of the elements in the cement were activated producing γ-emitting radionuclides that were measured with a NaI(Tl) gamma-ray spectrometer, that was calibrated with point-like sources. In order to determine the specific activity in the induced radioisotopes calculated efficiencies were used to make corrections due to the differences between the solid angle, photon absorption and photon scattering in the point-like calibration sources and the sources distributed in cement. During the interaction between photoneutrons and the cement samples three radioisotopes were induced: {sup 56}Mn, {sup 24}Na, and {sup 28}Al. (Author)

  2. Linguagens na TV Languages on tv

    Directory of Open Access Journals (Sweden)

    Glaucia Guimarães

    2008-06-01

    Full Text Available Este artigo aborda questões relativas às estratégias discursivas utilizadas na produção dos textos televisivos. Com base na Análise Crítica de Discurso (ACD, nos termos em que é formulada por Norman Fairclough, o trabalho analisa os modos pelos quais as linguagens (incluindo materiais semióticos diversos são articuladas na/pela TV, sistematiza as relações entre a articulação de linguagens e a produção de efeitos de sentido, bem como os modos de sua inscrição nas tendências discursivas contemporâneas, a saber: democratização, tecnologização e comodificação. A partir das relações entre as práticas de linguagem e as tendências destacadas, o artigo tece considerações sobre as condições de produção de leituras críticas dos textos multimidiáticos, nas suas múltiplas dimensões: dos contextos e mecanismos da produção textual à pluralidade constitutiva de sua recepção.This paper deals with issues related to discursive strategies in the production of TV texts. Based on Critical Discourse Analysis (CDA, as formulated by Norman Fairclough, it analyzes the ways languages (including several semiotic materials are articulated in order to produce a range of wanted meaning effects, as well as the ways they are inscribed in the contemporary discursive trends discussed by the author, namely: democratization, technologization and commodification. Departing from the analysis of language practices and the discursive trends underlined, the paper aims at clarifying the multiple dimensions of multimedia conditions of production, focusing on both the context and the mechanisms and the diverse reception (reading possibilities.

  3. Na(+),K (+)-ATPase as a docking station: protein-protein complexes of the Na(+),K (+)-ATPase.

    Science.gov (United States)

    Reinhard, Linda; Tidow, Henning; Clausen, Michael J; Nissen, Poul

    2013-01-01

    The Na(+),K(+)-ATPase, or sodium pump, is well known for its role in ion transport across the plasma membrane of animal cells. It carries out the transport of Na(+) ions out of the cell and of K(+) ions into the cell and thus maintains electrolyte and fluid balance. In addition to the fundamental ion-pumping function of the Na(+),K(+)-ATPase, recent work has suggested additional roles for Na(+),K(+)-ATPase in signal transduction and biomembrane structure. Several signaling pathways have been found to involve Na(+),K(+)-ATPase, which serves as a docking station for a fast-growing number of protein interaction partners. In this review, we focus on Na(+),K(+)-ATPase as a signal transducer, but also briefly discuss other Na(+),K(+)-ATPase protein-protein interactions, providing a comprehensive overview of the diverse signaling functions ascribed to this well-known enzyme.

  4. Importance of Residues Outside the Cation Binding Pocket for Na+ and K+ Binding to the Na+/K+-ATPase

    DEFF Research Database (Denmark)

    Christiansen, Line; Toustrup-Jensen, Mads Schak; Einholm, Anja P.

    Mutagenesis studies have identified several oxygen-containing residues in the transmembrane region which are important for the coordination of Na+ and/or K+. These were later confirmed by the high-resolution crystal structures of the Na+/K+-ATPase with bound Na+ or K+. However, more information...... is needed to reveal the translocation pathway through the Na+/K+-ATPase. Mutagenesis studies have shown that several other transmembrane residues located outside the cation binding pocket, including Phe785 and Phe788, affect the ion binding properties of the Na+/K+-ATPase (1,2). It is well...... not significantly affect the Na+ binding properties of the Na+/K+-ATPase. 1. Vilsen, B. (1999) Biochemistry 38, 11389 2. Rodacker, V. et al (2006) JBC 281, 18539 3. Laursen M et al. (2013) PNAS 110, 10958...

  5. Effect of growth in lithium on ouabain binding, Na-K-ATPase and Na and K transport in hela cells.

    Science.gov (United States)

    Boardman, L J; Hume, S P; Lamb, J F; Polson, J

    1975-01-01

    1. HeLa cells were grown for 24 hr in growth medium in which part of the Na was replaced with Li. Ion contents, cell volumes and numbers, Na-K-ATPase and specific ouabain binding were measured. In some experiments the Na efflux and net Na transport was also measured. 2. Growth in Li caused a rise in the specific ouabain binding and membrane Na-K-ATPase of these cells. The Li concentrations in the cells necessary to produce this effect ranged up to 50 mM. 3. It is suggested that Li, like Na, acts on the genetic material of the cells to cause the production of more Na pumps within the membrane. PMID:124350

  6. The NA48 liquid krypton prototype calorimeter

    Energy Technology Data Exchange (ETDEWEB)

    Barr, G.D.; Buchholz, P.; Carosi, R.; Coward, D.; Cundy, D.; Doble, N.; Gatignon, L.; Gonidec, A.; Hallgren, B.; Kesseler, G.; Lacourt, A.; Laverriere, G.; Linser, G.; Mast, M.; Schilly, P.; Schinzel, D.; Seidl, W.; Taureg, H.; Wahl, H.; Wicht, P. (CERN, Geneva (Switzerland)); Bertanza, L.; Bigi, A.; Calafiura, P.; Casali, R.; Cerri, C.; Fantechi, R.; Gennaro, G.; Gorini, B.; Mannelli, I.; Marzulli, V.; Pierazzini, G.; Schiuma, D.; Sergiampietri, F. (INFN, Pisa (Italy) Scuola Normale, Pisa (Italy) Univ. Pisa (Italy)); Bederede, D.; Debeer, M.; Debu, P.; Peyaud, B. (CE-Saclay-DAPNIA, 91 - Gif-sur-Yvette (France)); Kreutz, A. (Univ. Gesamthochschule Siegen (Germany)); Griesmayer, E.; Markytan, M.; Neuhofer, G.; Pernicka, M.; Taurok, A.; Viehhauser, G.; Wulz, C.E. (Oesterreichische Akademie der Wissenschaften, Inst. fuer Hochenergiephysik, Vienna (Austria)); Cagliari-Cambridge-CERN-Dubna-Edingburgh-Ferrara-Mainz-Perugia-Pisa-Saclay-Siegen-Torino-Vienna Collaboration

    1992-12-01

    The NA48 experiment for a precision measurement of the CP violation parameter element of'/element of in K[sup 0][yields]2[pi] decays will require a fast electromagnetic calorimeter with excellent energy and time resolution. A quasi homogeneous calorimeter using liquid krypton and a fast readout with 40 MHz FADCs is proposed. A prototype with 400 kg of liquid krypton was built and tested in an electron beam. Results for the energy, space and time resolution of this prototype are given. (orig.).

  7. Holistična obravnava motenj hranjenja

    OpenAIRE

    Arzenšek, Pia

    2017-01-01

    Izhodišča: Stres, nepravičnost, nespoštljivost, mediji, kot socialni, ter biološko-genetski, družinski in psihološki dejavniki tveganja v kombinacijah vplivajo na razvoj različnih motenj, bolezni, tudi motenj hranjenja (MH). Najpogostejše med njimi so anorexia nervosa, bulimija nervosa in kompulzivno prenajedanje, kot duševne motnje po mednarodni klasifikaciji. V novejšem času se pojavljajo nove oblike MH (ortoreksija, bigoreksija…). O MH govorimo kadar hrana postane osrednja tema posamezniko...

  8. O estresse na atividade gerencial do enfermeiro

    OpenAIRE

    Lautert Liana; Chaves Enaura H. B.; Moura Gisela M. S. S. de

    1999-01-01

    O trabalho do enfermeiro, principalmente no âmbito hospitalar, está, conforme diversos estudos, entre os que mais geram estresse em seus profissionais. Dessa forma, o objetivo desta investigação foi identificar as fontes geradoras de estresse na atividade gerencial do enfermeiro que trabalha no hospital e as principais alterações que o estresse pode acarretar sobre a saúde desse profissional. Trata-se de uma pesquisa quantitativa com uma amostra de 207 enfermeiros, realizada em 1996 em um hos...

  9. Results on leptonic probes from NA50

    CERN Document Server

    Alessandro, B; Arnaldi, R; Atayan, M; Baglin, C; Baldit, A; Bedjidian, Marc; Beolè, S; Boldea, V; Bordalo, P; Borenstein, S R; Borges, G; Bussière, A; Capelli, L; Castanier, C; Castor, J I; Chaurand, B; Cheynis, B; Chiavassa, E; Cicalò, C; Claudino, T; Comets, M P; Constantinescu, S; Cortese, P; Cruz, J; De Falco, A; De Marco, N; Dellacasa, G; Devaux, A; Dita, S; Drapier, O; Espagnon, B; Fargeix, J; Force, P; Gallio, M; Gavrilov, Yu K; Gerschel, C; Giubellino, P; Golubeva, M B; Gonin, M; Grigorian, A A; Grigorian, S; Grossiord, J Y; Guber, F F; Guichard, A; Gulkanian, H R; Hakobyan, R S; Haroutunian, R; Idzik, M; Jouan, D; Karavitcheva, T L; Kluberg, L; Kurepin, A B; Le Bornec, Y; Lourenço, C; Macciotta, P; MacCormick, M; Marzari-Chiesa, A; Masera, M; Masoni, A; Monteno, M; Musso, A; Petiau, P; Piccotti, A; Pizzi, J R; Prado da Silva, W L; Prino, F; Puddu, G; Quintans, C; Ramello, L; Ramos, S; Rato-Mendes, P; Riccati, L; Romana, A; Santos, H; Saturnini, P; Scalas, E; Scomparin, E; Serci, S; Shahoyan, R; Sigaudo, F; Sitta, M; Sonderegger, P; Tarrago, X; Topilskaya, N S; Usai, G L; Vercellin, Ermanno; Villatte, L; Willis, N; Wu, T

    2003-01-01

    The NA50 Collaboration has performed a new measurement of the J/ psi yield in Pb-Pb collisions at 158 GeV/nucleon in improved experimental conditions. Our preliminary analysis of the year 2000 data sample, while confirming the onset of anomalous suppression and the non saturation of the J/ psi /Drell-Yan cross-section ratio, shows that peripheral Pb-Pb interactions follow the normal nuclear absorption pattern, which has in turn been established more precisely thanks to high statistics p-A data. (11 refs).

  10. Processo de pintura na Preh Portugal

    OpenAIRE

    Pontes, José Luís Pereira

    2016-01-01

    Neste estágio trabalhei no departamento de Engenharia de Processo e Automatização. Os Engenheiros que trabalham nesse departamento têm diversas funções. Desde ser responsáveis por uma linha de montagem; responsável por todas as alterações de engenharia; responsável pela parte eletrónica; responsável pela parte de pintura; entre outras. Também auxiliei na criação e atualização de Standards dentro da organização. Inicialmente, estes Standards ou estavam em formato Excel com basta...

  11. Cerenkov counter for the experiment NA3

    CERN Multimedia

    1978-01-01

    The program of the NA3 experiment included the study of hadronic interactions with a large transverse momentum pT, thus the inclusion in the set-up of three gas threshold Cerenkov counters of large acceptance. The photo shows the downstream part of the second Cerenkov (located at the output of the magnet). The yellow membrane is a temporary protection for the optics (shown in photo 7810540X) to be taken away when fixing this part to the gas tank (entering the magnet and not shown). The photomultipliers all around are heavily shielded.

  12. Sexualidade, Espiritualidade e Conjugalidades na Wicca Brasileira

    OpenAIRE

    Cordovil, Daniela

    2017-01-01

    Resumo Este artigo propõe uma análise do papel da sexualidade nas práticas da Wicca, religião neopagã surgida na Inglaterra entre 1940 e 1950. Atualmente, a Wicca é um movimento mundial multifacetado, que segue inúmeras vertentes. Esta pesquisa investiga concepções e práticas ligadas à sexualidade presentes entre grupos que praticam a Wicca publicamente em diversas capitais do Brasil. Esses grupos estão organizados em tradições (grupos religiosos com viés iniciático) que comandam associações ...

  13. Qualidade de vida na epilepsia infantil

    OpenAIRE

    SOUZA ELISABETE ABIB PEDROSO DE

    1999-01-01

    A epilepsia é desordem crônica que ocorre principalmente na infância e adolescência. Tradicionalmente, o tratamento da epilepsia enfatiza aspectos neurológicos mais do que fatores psicológicos. A aten��ão voltada simplesmente para o controle das crises no contexto clínico pode não ser suficiente para entender a grande amplitude de problemas que afetam a qualidade de vida das crianças com epilepsia. Muitas das dificuldades psicossociais dos adultos com epilepsia desenvolvem-se a partir de comp...

  14. DEPRESSÃO E ENVELHECIMENTO NA CONTEMPORANEIDADE

    Directory of Open Access Journals (Sweden)

    Delia Catullo Goldfarb

    2010-02-01

    Full Text Available RESUMO: O presente texto reproduz os trabalhos apresentados em mesa redonda sobre depressão e envelhecimento na contemporaneidade no III Congresso Ibero-americano de Psicogerontologia, realizado em novembro de 2010 em São Paulo. Estes trabalhos são resultado de reflexões precedentes em um grupo de estudos e de discussão de casos clínicos composto por psicanalistas. A depressão é uma figura psicopatológica de presença maciça nos dias de hoje. Na velhice o acúmulo de perdas e a aproximação da morte podem produzir um estado de tristeza, fundo depressivo que caracteriza um momento de recolhimento em que ocorrem os processos de luto. Em alguns sujeitos o que se verifica é a instalação de um episódio depressivo que indica a paralisação destes processos elaborativos e a progressão de um esvaziamento do sentido para a vida, restando, neste contexto, apenas a espera pela morte. Neste trabalho serão discutidos aspectos que concernem a vivência destas duas modalidades de enfrentamento da entrada na velhice, levando-se em conta as maneiras como a cultura pode favorecer a ocorrência destes percursos distintos do envelhecer, e como ela os aloja atualmente em um movimento de desconsideração da subjetividade: desanimo da velhice ou problema neuroquímico? Serão apresentadas hipóteses para a produção da depressão como psicopatologia no envelhecimento e reflexões sobre observações clínicas que derivam destes quadros clínicos, tais como: a crise da percepção da entrada na velhice, o corpo hipocondríaco, a paralisia do tempo, a vivência do desamparo. Palavras-chave: depressão, envelhecimento, cultura, corpo, tempo

  15. O mito da autoestima na aprendizagem escolar

    OpenAIRE

    Franco, Adriana de Fátima

    2009-01-01

    Este artigo analisa, nos marcos da perspectiva sócio-histórica, a construção social da autoestima e suas relações com o fracasso escolar. Fundamentada nos pressupostos de Vigotski, nega a possibilidade da valoração que o sujeito faz de si estar atrelada a atributos naturalmente humanos e presentes desde o nascimento. A compreensão do ser humano é feita a partir de uma análise de homem enquanto ser concreto, social, histórico e cultural que constrói sua humanidade na interação com outros homen...

  16. O dano pessoal na sociedade de risco

    OpenAIRE

    Hofmeister, Maria Alice Costa

    2000-01-01

    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Jurídicas. Estudo do dano pessoal e sua indenização, sob a ótica do dano corporal. Equaciona-se a matéria a partir do homem na pós-modernidade. Conclui-se que urge repensar as normas à luz de uma interpretação constitucional para atender à função mais importante da responsabilidade hoje reconhecida: indenizar a vítima. A indenização deverá ser reorientada para priorizar as necessidades da vítima em concreto. ...

  17. O TRADICIONALISMO NA LINGUAGEM JURÍDICA

    OpenAIRE

    Eliane Simões Pereira Bulhões

    2009-01-01

    Este artigo tem como objetivo analisar alguns aspectos do discurso atual do Direito brasileiro. Apoiando-se em pressupostos teóricos do lingüista russo Mikhail Bakhtin (1895-1975), segundo os quais a linguagem é instância ideológica por excelência, presentes na obra Marxismo e filosofia da linguagem, procuramos avaliar a linguagem jurídica como expressão do componente ideológico. Para tanto utilizamos um modelo de petição jurídica colhido em um guia para advogados, o qual nos serve como corpu...

  18. O TRADICIONALISMO NA LINGUAGEM JURÍDICA

    Directory of Open Access Journals (Sweden)

    Eliane Simões Pereira Bulhões

    2009-02-01

    Full Text Available Este artigo tem como objetivo analisar alguns aspectos do discurso atual do Direito brasileiro. Apoiando-se em pressupostos teóricos do lingüista russo Mikhail Bakhtin (1895-1975, segundo os quais a linguagem é instância ideológica por excelência, presentes na obra Marxismo e filosofia da linguagem, procuramos avaliar a linguagem jurídica como expressão do componente ideológico. Para tanto utilizamos um modelo de petição jurídica colhido em um guia para advogados, o qual nos serve como corpus representativo da linguagem forense.

  19. [Effects of NaCl stress on the seedling growth and K(+)- and Na(+) -allocation of four leguminous tree species].

    Science.gov (United States)

    Mo, Hai-Bo; Yin, Yun-Long; Lu, Zhi-Guo; Wei, Xiu-Jun; Xu, Jian-Hua

    2011-05-01

    Taking the pot-cultured seedlings of four leguminous tree species (Albizia julibrissin, Robinia pseudoacacia, Sophora japonica, and Gleditsia sinensis) as test materials, this paper studied their growth indices, critical salt concentration (C50), and K+ and Na+ allocation under different levels of NaCl stress, aimed to understand the difference of test tree species in salt tolerance. NaCl stress inhibited the seedling growth of the tree species. Under NaCl stress, the dry matter accumulation decreased, while the root/shoot ratio increased, especially for A. julibrissin and G. sinensis. Quadratic regression analysis showed that the C50 of A. julibrissin, R. pseudoacacia, S. japonica, and G. sinensis was 3.0 per thousand, 5.0 per thousand, 4.5 per thousand, and 3.9 per thousand, respectively, i.e., the salt tolerance of the four tree species was in the order of R. pseudoacacia > S. japonica > G. sinensis > A. julibrissin. In the root, stem, and leaf of the four tree species seedlings, the Na+ content increased with the increase of NaCl stress, while the K+ content (except in the root of A. julibrissin) decreased after an initial increase, resulting in a larger difference in the K+/Na+ ratio in the organs. Under the same NaCl stress, the allocation of Na+ in different organs of the four tree species seedlings decreased in the order of root>stem>leaf, while that of K+ differed with tree species and NaCl stress, and leaf was the main storage organ for K+. The K+/Na+ ratio in different organs decreased in the sequence of leaf>stem>root. R. pseudoacacia under NaCl stress accumulated more K+ and less Na+ in stem and leaf, and had higher K+/Na+ ratio in all organs and higher dry mass, being assessed to be more salt-tolerant. In contrast, A. julibrissin under high NaCl stress accumulated more Na+ in stem and leaf, and had a lower K+/Na+ ratio in all organs and lower dry mass, being evaluated to be lesser salt-tolerant. The K+ accumulation in seedling stem and leaf and the Na

  20. Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease

    DEFF Research Database (Denmark)

    Toustrup-Jensen, Mads Schak; Einholm, Anja P.; Schack, Vivien

    was observed for the +28 mutation of α2 despite a high expression level. A significant rise of [Na+]i and reduction of [K+]i was detected in cells expressing mutants with reduced Na+ affinity and did not require a concomitant reduction of the maximal catalytic turnover rate or expression level. Moreover, two...

  1. Adsorbed or intercalated: Na on graphene/Ir(111)

    Science.gov (United States)

    Pervan, Petar; Lazić, Predrag

    2017-09-01

    Interaction of sodium with graphene (Gr) on Ir(111) was studied with the aim to resolve the issue of Na adsorption/intercalation kinetics. The system Na/Gr/Ir(111) was studied by means of angle-resolved photoemission spectroscopy, low-energy electron diffraction, and ab initio density functional theory (DFT) calculation. It has been found that at room temperature (RT) and low concentrations Na is dominantly adsorbed on graphene. At higher concentrations, an intercalation process sets in so that it is possible to observe the coexistence of these two states. Eventually, all Na atoms are found in the intercalated state as determined by exposure to oxygen. While adsorption of Na on graphene already intercalated by Na [Na/Gr/Na/Ir(111) system] at RT was not possible, we could observe Li adsorption through the increase of Dirac point binding energy. Li coadsorption strongly affects the binding energy of the iridium surface state as well. This finding was supported by DFT calculations of adsorption energy of Na and Li on bare and fully Na intercalated graphene.

  2. Advancement of technology towards developing Na-ion batteries

    Science.gov (United States)

    Jamesh, Mohammed Ibrahim; Prakash, A. S.

    2018-02-01

    The Na-ion-batteries are considered much attention for the next-generation power-sources due to the high abundance of Na resources that lower the cost and become the alternative for the state of the art Li-ion batteries in future. In this review, the recently reported potential cathode and anode candidates for Na-ion-batteries are identified in-light-of-their high-performance for the development of Na-ion-full-cells. Further, the recent-progress on the Na-ion full-cells including the strategies used to improve the high cycling-performance (stable even up-to 50000 cycles), operating voltage (even ≥ 3.7 V), capacity (>350 mAhg-1 even at 1000 mAg-1 (based-on-mass-of-the-anode)), and energy density (even up-to 400 Whkg-1) are reviewed. In addition, Na-ion-batteries with the electrodes containing reduced graphene oxide, and the recent developments on symmetric Na-ion-batteries are discussed. Further, this paper identifies the promising Na-ion-batteries including the strategies used to assemble full-cell using hard-carbon-anodes, Na3V2(PO4)3 cathodes, and other-electrode-materials. Then, comparison between aqueous and non-aqueous Na-ion-batteries in terms of voltage and energy density has been given. Later, various types of electrolytes used for Na-ion-batteries including aqueous, non-aqueous, ionic-liquids and solid-state electrolytes are discussed. Finally, commercial and technological-developments on Na-ion-batteries are provided. The scientific and engineering knowledge gained on Na-ion-batteries afford conceivable development for practical application in near future.

  3. Apical Na+ permeability of frog skin during serosal Cl- replacement.

    Science.gov (United States)

    Leibowich, S; DeLong, J; Civan, M M

    1988-05-01

    Gluconate substitution for serosal Cl- reduces the transepithelial short-circuit current (Isc) and depolarizes short-circuited frog skins. These effects could result either from inhibition of basolateral K+ conductance, or from two actions to inhibit both apical Na+ permeability (PapNa) and basolateral pump activity. We have addressed this question by studying whole-and split-thickness frog skins. Intracellular Na+ concentration (CcNa) and PapNa have been monitored by measuring the current-voltage relationship for apical Na+ entry. This analysis was conducted by applying trains of voltage pulses, with pulse durations of 16 to 32 msec. Estimates of PapNa and CcNa were not detectably dependent on pulse duration over the range 16 to 80 msec. Serosal Cl- replacement uniformly depolarized short-circuited tissues. The depolarization was associated with inhibition of Isc across each split skin, but only occasionally across the whole-thickness preparations. This difference may reflect the better ionic exchange between the bulk medium and the extracellular fluid in contact with the basolateral membranes, following removal of the underlying dermis in the split-skin preparations. PapNa was either unchanged or increased, and CcNa either unchanged or reduced after the anionic replacement. These data are incompatible with the concept that serosal Cl- replacement inhibits PapNa and Na,K-pump activity. Gluconate substitution likely reduces cell volume, triggering inhibition of the basolateral K+ channels, consistent with the data and conclusions of S.A. Lewis, A.G. Butt, M.J. Bowler, J.P. Leader and A.D.C. Macknight (J. Membrane Biol. 83:119-137, 1985) for toad bladder. The resulting depolarization reduces the electrical force favoring apical Na+ entry. The volume-conductance coupling serves to conserve volume by reducing K+ solute loss. Its molecular basis remains to be identified.

  4. Estudo comparativo entre ropivacaína a 0,5% e bupivacaína a 0,5% ambas hiperbáricas, na raquianestesia

    OpenAIRE

    Carvalho, Afonso Cláudio dos Reis e; Machado, Jean Abreu; Nociti, José Roberto

    2002-01-01

    JUSTIFICATIVA E OBJETIVOS - Estudos clínicos e experimentais já demonstraram a eficácia e a segurança da ropivacaína aplicada a estruturas nervosas por via subaracnóidea. Por outro lado, a potência da ropivacaína em raquianestesia é aproximadamente igual à metade da potência de bupivacaína, considerando-se soluções hiperbáricas. O objetivo deste estudo foi comparar as características do bloqueio subaracnóideo com ropivacaína ou bupivacaína hiperbáricas, em doses equipotentes. MÉTODO - Vinte p...

  5. Saturation effects in Na lidar temperature measurements

    International Nuclear Information System (INIS)

    von der Gathen, P.

    1991-01-01

    Na atoms residing in the 80-110 km altitude region can be used to probe the Doppler-broadened hyperfine structure (hfs) of their D 2 resonance by ground-bases lidar and hence to deduce atmospheric temperatures. In principle, two different methods may be employed: (1) wavelength scanning of the hfs with a narrow-band laser and signal detection with a broad-band receiver, and (2) use of a broad-band laser and wavelength scanning of the hfs with a narrow-band receiver. These two methods are affected in different ways by laser-induced saturation in the Na layer, the effect on the measurements of sodium densities and of atmospheric temperatures being quite different. Density measurements are affected by the absolute level of saturation. Temperature measurements, however, are affected by the difference in saturation at the scanned wavelengths. If, additionally, observed signal levels are taken into account, method 1 is more efficient than method 2 for both types of measurements at nighttime, whereas a modified method 2 surpasses method 1 for temperature measurements at daytime

  6. ESTUDO DO EMPODERAMENTO NA PERSPECTIVA DAS MULHERES

    Directory of Open Access Journals (Sweden)

    Karoline Brasil de Oliveira

    2015-12-01

    Full Text Available Este trabalho objetivou conhecer como as mulheres que ocupam cargos de liderança, utilizam o empoderamento no exercício profissional em uma instituição de ensino e tecnologia em Criciúma, Santa Catarina, Brasil. Na revisão da literatura foram contextualizados a mulher e sua inserção no mercado de trabalho, em busca de uma concepção de empoderamento e as dimensões do empoderamento da mulher no mercado de trabalho. A metodologia utilizada teve caráter descritivo e qualitativo. O instrumento de coleta de dados consistiu num roteiro com 16 questões que abordaram o bem-estar e sucesso profissional, o reconhecimento familiar, o processo de ascensão profissional e a participação das mulheres nos processos decisórios organizacionais. A pesquisa foi realizada com 10 mulheres que ocupavam cargos de chefia em diferentes setores da instituição em análise. Os resultados obtidos na pesquisa revelaram que as entrevistadas já demonstram expressões de empoderamento em seus cotidianos e a mulher se apresenta mais confiante e preparada para participar das tomadas de decisões em níveis hierárquicos maiores, além de interferir no próprio meio.

  7. Desafios na gestão escolar

    Directory of Open Access Journals (Sweden)

    Flávia Obino Corrêa Werle

    2015-09-01

    Full Text Available Este estudo discute a avaliação em larga escala da educação básica, os processos de regulação e debate processos de gestão realizados no interior da escola pública. Seu objetivo é compreender como a equipe diretiva de duas escolas da rede pública estadual de Porto Alegre, Brasil, se apropria dos resultados do Indíce de Desenvolvimento da Educação Básica (IDEB e como lida com eles na gestão escolar. A metodologia utilizada é de cunho qualitativo com coleta de dados através de um questionário estruturado. Apresenta os resultados do IDEB das duas escolas no período de 2009 e 2011. Na prática escolar a apropriação ocorre em três dimensões (pedagógica, administrativa e participativa e promove diálogos em diferentes níveis: com a hierarquia do sistema educacional, com a comunidade externa à escola e, internamente, com os professores e demais membros da comunidade escolar.

  8. Criptococose pulmonar: aspectos na tomografia computadorizada

    Directory of Open Access Journals (Sweden)

    Silva Ana Carina Gamboa da

    2003-01-01

    Full Text Available A criptococose pulmonar é uma doença causada pelo Criptococcus neoformans, um fungo unimórfico que possui distribuição mundial, existindo na mesma forma tanto no seu habitat natural quanto em animais e humanos. A doença possui apresentações clínica e patológica variáveis e pode manifestar-se tanto em pacientes com a imunidade normal como em imunocomprometidos, que representam a maioria dos casos. Neste trabalho são analisados os aspectos encontrados nas tomografias computadorizadas do tórax de 14 pacientes com criptococose pulmonar confirmada. Os achados mais freqüentes na tomografia do tórax foram as massas e os nódulos pulmonares. Outros aspectos observados foram as áreas de escavação, as consolidações, o espessamento do interstício peribroncovascular e o reticulado difuso. Massa pulmonar foi o achado isolado mais comum (64,2%, seguido dos nódulos isolados ou múltiplos (35,7%. Doença pulmonar difusa foi vista em apenas 14,2% dos casos. Os lobos superiores foram os mais comprometidos, sendo a doença mais comum nas regiões anteriores. A tomografia do tórax permitiu avaliar com precisão o grau de comprometimento do parênquima pulmonar.

  9. Vinhos, Turismo e Pluriatividade na Agricultura

    Directory of Open Access Journals (Sweden)

    Hernanda Tonini

    2013-06-01

    Full Text Available A gastronomia, além de ter importante relação com a economia, é uma forma expressiva da cultura dos indivíduos, desde o tipo de alimentos cultivados até a maneira de seu preparo e consumo. O presente artigo propõe-se a analisar a relação entre o enoturismo – centralizado na existência do vinho enquanto elemento gastronômico – e o fenômeno da pluriatividade na agricultura familiar, vista nos últimos anos como alternativa positiva para sua reprodução econômica e social. O fluxo turístico em regiões vitivinícolas gera novas oportunidades de trabalho e faz com que agricultores e suas famílias dividam a mão de obra agrícola, até então direcionada ao cultivo da uva e outros alimentos para subsistência, com atividades não agrícolas – como o artesanato, o acolhimento de visitantes em pousadas, a atuação em restaurantes, entre outras – como chance de subsistência. Este panorama transforma as realidades do mundo rural, alterando a relação do agricultor com a produção de alimentos e a forma como o mesmo os utiliza, além de reestruturar o ambiente sociocultural no seu entorno.  

  10. Brasileiros na fronteira com o Paraguai

    Directory of Open Access Journals (Sweden)

    Marcia Anita Sprandel

    2006-08-01

    Full Text Available O ARTIGO apresenta uma cartografia da situação social dos brasileiros e seus descendentes que vivem no Paraguai. Os distintos mapas (artigos, dissertações, teses e relatórios, com suas múltiplas perspectivas, permitem que se relativizem as narrativas midiáticas e a concepção da região como "lugar difícil". Ao discorrer sobre trabalhos de diversos autores, de distintas áreas acadêmicas, o artigo aponta para a mportância de cada um deles na construção de uma análise que traduza a pluralidade de pontos de vista coexistentes na região e que são, muitas vezes, inconciliáveis.THE ARTICLE presents a cartography of the social situation of the Brazilians and its descendants who live in Paraguay. The distinct maps (articles, these and reports deconstruct the media’s narratives and the conception of the region as a "difficult place". Works of diverse authors, of distinct academic areas, demonstrate the importance of each one of them in the construction of an analysis that translates the plurality of points of view.

  11. A biotecnologia na agropecuária

    Directory of Open Access Journals (Sweden)

    João Lúcio de Azevedo

    1986-11-01

    Full Text Available This review reports the use of biotechnology in agriculture and animal husbandry. The main techniques and the most important products both in experimental stage or in commercial use are reported. The work intends to give a global vision to the theme, chronologically and spacely, showing the main lines of research and what has been obtained in this area. The techniques and products that are related to genetics and breeding are emphasized. Revisão Bibliográfica do emprego da biotecnologia na agropecuária, mostrando um levantamento das técnicas mais promissoras e de seus principais produtos, tanto em fase experimental como em uso comercial. Pretende-se dar uma visão global do assunto, cronológica e espacialmente, não se prendendo à detalhes, mostrando, em Unhas gerais, o que foi feito e o que se faz, atualmente, em biotecnologia. As técnicas e produtos que influenciam a área de genética e melhoramento genético na agropecuária, são enfatizadas.

  12. The NA62 GigaTracker

    Science.gov (United States)

    Aglieri Rinella, G.; Alvarez Feito, D.; Arcidiacono, R.; Biino, C.; Bonacini, S.; Ceccucci, A.; Chiozzi, S.; Gil, E. Cortina; Ramusino, A. Cotta; Degrange, J.; Fiorini, M.; Gamberini, E.; Gianoli, A.; Kaplon, J.; Kluge, A.; Mapelli, A.; Marchetto, F.; Minucci, E.; Morel, M.; Noël, J.; Noy, M.; Perktold, L.; Perrin-Terrin, M.; Petagna, P.; Petrucci, F.; Poltorak, K.; Romagnoli, G.; Ruggiero, G.; Velghe, B.; Wahl, H.

    2017-02-01

    The GigaTracker is a hybrid silicon pixel detector built for the NA62 experiment aiming at measuring the branching fraction of the ultra-rare kaon decay K+ →π+ ν ν bar at the CERN SPS. The detector has to track particles in a beam with a flux reaching 1.3 MHz/mm2 and provide single-hit timing with 200 ps RMS resolution for a total material budget of less than 0.5% X0 per station. The tracker comprises three 60.8 mm×27 mm stations installed in vacuum (∼10-6 mbar) and cooled with liquid C6F14 circulating through micro-channels etched inside a few hundred micron thick silicon plates. Each station is composed of a 200 μm thick silicon sensor read out by 2×5 custom 100 μm thick ASICs, called TDCPix. Each chip contains 40×45 asynchronous pixels, 300 μm×300 μm each and is instrumented with 100 ps bin time-to-digital converters. In order to cope with the high rate, the TDCPix is equipped with four 3.2 Gb/s serialisers sending out the data. We will describe the detector and the results from the 2014 and 2015 NA62 runs.

  13. The NA62 GigaTracker

    CERN Document Server

    Perrin-Terrin, Mathieu

    2015-01-01

    The GigaTracker is an hybrid silicon pixel detector built for the NA62 experiment aiming at measuring the branching fraction of the ultra-rare kaon decay K + ! p + n ̄ n at the CERN SPS. The detector has to track particles in a beam with a flux reaching 1.3 MHz/mm 2 and provide single-hit timing with 200ps RMS resolution for a total material budget of less than 1.5 X 0 . The tracker comprises three 60.8mm 27mm stations installed in vacuum ( 10$^{-6}$ mbar) and cooled with liquid C 6 F 14 circulating through micro-channels etched inside few hundred of microns thick silicon plates. Each station is composed of a 200 m m thick silicon sensor readout by 2 x 5 cus- tom 100 m m thick ASIC, called TDCPix. Each chip contains 40 x 45 asynchronous pixels, each 300 m m x 300 m m and is instrumented with 100ps bin time-to-digital converters. In order to cope with the high rate, the TDCPix is equipped with four 3.2Gb/s serialisers sending out the data. We will describe the detector and the results from the 2014 NA62 ru...

  14. Mercosul educativo na carreira de Enfermagem

    Directory of Open Access Journals (Sweden)

    Roseli Schmoeller

    2012-10-01

    Full Text Available O Mercosul, instituído com vistas à integração econômica, política, social e cultural entre os países membros, atualmente destaca-se pelas estratégias integrativas de âmbito educacional. Este artigo aborda os movimentos acerca da formação acadêmica dos cursos de Enfermagem e o trajeto histórico de integração educacional, apresentando o Sistema de Acreditação dos Cursos Universitários do Mercosul, o ARCU-SUL, além dos setores responsáveis por esse processo e as perspectivas para a Enfermagem nos países do Mercosul. Entendemos que para o desenvolvimento de profissionais críticos, reflexivos e com compromisso político-social, é fundamental investir na formação e na qualidade dos centros de ensino em Enfermagem.

  15. NA-CORDEX: Overview and Sample Results

    Science.gov (United States)

    Bukovsky, Melissa; Mearns, Linda; Arritt, Raymond; Castro, Christopher; Chang, Hsin-I.; Christensen, Jens; Christensen, Ole; Frigon, Anne; Gutowski, William; Kjellström, Erik; Laprise, René; McGinnis, Seth; Nikulin, Grigory; Scinocca, John; Sushama, Laxmi; Winger, Katje

    2017-04-01

    The North American CORDEX program (NA-CORDEX) has produced a good number of projections of climate according to the first phase of the CORDEX program. These simulations are based on a wide range of regional and global climate models, and some matrices of combinations have resulted. The RCMs involved include: WRF, CanRCM4, CRCM5, RegCM4, RCA4, and HirHam5. Driving GCMs include: EC-EARTH, CanESM2, HadGEM2-ES, GFDL-ESM2M, MPI-ESM-LR. These GCMs nicely span the equilibrium climate sensitivity of the GCMs making up the CMIP5 suite of models. Simulations have been performed both at .44 and .22 spatial resolutions and often for both RCP8.5 and 4.5. We will present an update of the status of NA-CORDEX, an overview of the simulations, and some of the results for North America, focusing on the quality of the baseline climate simulations and the projections of precipitation and temperature.

  16. NA-CORDEX: Overview and New Results

    Science.gov (United States)

    Mearns, L.; Arritt, R. W.; Bukovsky, M. S.; Castro, C. L.; Chang, H. I.; Christensen, J. H.; Christensen, O. B.; Gutowski, W. J., Jr.; Kjellstrom, E.; Laprise, R.; McGinnis, S. A.; Nikulin, G.; Scinocca, J. F.; Sushama, L.; Frigon, A.; Winger, K.

    2017-12-01

    The North American CORDEX program (NA-CORDEX) has produced a good number of projections of climate according to the first phase of the CORDEX program. These simulations are based on a wide range of regional and global climate models, and some matrices of combinations have resulted. The RCMs involved include: WRF, CanRCM4, CRCM5, RegCM4, RCA4, and HirHam5. Driving GCMs include: EC-EARTH, CanESM2, HadGEM2-ES, GFDL-ESM2M, MPI-ESM-LR, and MPI-ESM-MR. These GCMs nicely span the equilibrium climate sensitivity of the GCMs making up the CMIP5 suite of models. Simulations have been performed both at .44 and .22 spatial resolutions and often for both RCP8.5 and 4.5. The time period for all simulations is 1950-2100. We will present an update of the results of NA-CORDEX, an overview of the simulations, and some detailed results for North America, focusing on the quality of the baseline climate simulations and the projections of precipitation and temperature. We will particularly focus on a 2 by 3 experiment with 2 RCMs driven by 3 GCMs. We also introduce a new metric for comparison of regional model results driven by GCMs of different climate sensitivities, which is regional model climate sensitivity.

  17. Autonomia e vulnerabilidade na vida dos adolescentes

    Directory of Open Access Journals (Sweden)

    Renata R. de Oliveira

    2007-05-01

    Full Text Available Este trabalho foi realizado com a finalidade de estabelecer relações entre os princípios éticos da autonomia e vulnerabilidade e a vida de adolescentes, pessoas reconhecidamente passíveis de síndromes depressivas, uso abusivo de drogas ilícitas, alcoolismo e tabagismo. Famílias desestruturadas, pais ausentes, companhia de amigos que levam a diferentes vícios, facilidade de acesso a fontes desencontradas de informações e uma sociedade indiferente afetam o desenvolvimento normal dos jovens. Considera-se, ainda, o grande desafio apresentado a profissionais de saúde em agir na busca de reduzir a vulnerabilidade dos adolescentes e permitir que os mesmo usem de autonomia com responsabilidade na tomada de decisões em suas vidas pessoais. O cuidado com os mesmos deve ser mais integral e ativo e a sociedade ainda não reconheceu adequadamente a importância de cuidar do desenvolvimento saudável desse imenso contingente humano.

  18. ESCOLA NA OU DA PRISÃO?

    Directory of Open Access Journals (Sweden)

    Elionaldo Fernandes Julião

    Full Text Available RESUMO: Embora algumas experiências estaduais de educação para jovens e adultos em situação de restrição e privação de liberdade remontem há algumas décadas, somente a partir de 2005 é que se iniciam no Brasil encaminhamentos para implementação de uma política propriamente nacional, quando os Ministérios da Educação e da Justiça iniciaram uma proposta de articulação para implementação de Programa Nacional de Educação para o Sistema Penitenciário, formulando as suas diretrizes. Fundamentado em uma concepção crítica sobre o papel do sistema penitenciário na sociedade contemporânea, analisando as suas perspectivas políticas e pedagógicas, principalmente articulando os conceitos de garantias de direitos, políticas públicas, incompletude institucional e socialização, este artigo se propõe a investir na discussão sobre o papel da educação no sistema penitenciário, mais precisamente sobre a escola localizada no espaço carcerário.

  19. Direito do poeta na literatura de cordel

    Directory of Open Access Journals (Sweden)

    Sale Mário Gaudêncio

    Full Text Available Este artigo apresenta uma análise situacional dos direitos autorais na literatura de cordel, especialmente no que se refere à proteção moral e patrimonial que é dada aos poetas populares. Justifica-se o estudo em função de não haver profundas nem atuais discussões teóricas sobre a preservação moral e patrimonial em torno das obras de cordel. Utiliza-se como metodologia a pesquisa bibliográfica relacionada a um corpusque analisa os folhetos impressos por poetas da literatura de cordel. O estudo mostra como resultados o estabelecimento de um modelo alternativo de prazos para os direitos autorais na poesia popular, além da necessidade de ruptura técnica, política e cultural. Conclui informando sobre a importância de se construir um banco de dados nacional para que se tenha conhecimento pleno do quê e como se está produzindo a literatura de cordel, além de saber quem verdadeiramente está sendo beneficiado com tais produções.

  20. Mechanochemical transformations in Li(Na)AlH4-Li(Na)NH2 systems

    International Nuclear Information System (INIS)

    Dolotko, Oleksandr; Zhang Haiqiao; Ugurlu, Ozan; Wiench, Jerzy W.; Pruski, Marek; Scott Chumbley, L.; Pecharsky, Vitalij

    2007-01-01

    Mechanochemical transformations of tetrahydroaluminates and amides of lithium and sodium have been investigated using gas volumetric analysis, X-ray powder diffraction, solid-state nuclear magnetic resonance (NMR) and transmission electron microscopy. In a transformation of LiAlH 4 and LiNH 2 taken in an 1:1 molar ratio, the amount of released hydrogen (6.6 wt.% after 30 min ball milling) was higher than in any known one pot mechanochemical process involving a hydrogen-containing solid. A total of 4.3 wt.% of hydrogen is released by the NaAlH 4 -NaNH 2 system after 60 min ball milling; and 5.2 wt.% H 2 is released when LiAlH 4 and NaNH 2 or NaAlH 4 and LiNH 2 are ball milled for 90 min and 120 min, respectively. All transformations proceed at room temperature. The mechanism of the overall transformation MAlH 4 (s) + MNH 2 (s) → 2MH(s) + AlN(s) + 2H 2 (g) was identified based on detailed spectroscopic analysis of the intermediate (M 3 AlH 6 ) and final products of the ball milling process

  1. Aspectos valorizados por porfissionais de enfermagem na higiene pessoal e na higiene corporal do paciente

    Directory of Open Access Journals (Sweden)

    Elóide André Oliveira

    2003-10-01

    Full Text Available Survey descritivo, com o qual se objetivou identificar que aspectos da higiene corporal são valorizados pelos componentes da equipe de enfermagem, na higiene corporal pessoal e na higiene corporal do paciente. A pesquisa foi desenvolvida em oito instituições públicas de saúde e a amostra foi composta por 126 profissionais de enfermagem, correspondendo a 12,8% do total de 986 componentes das equipes de enfermagem destas instituições. Na higiene corporal pessoal, chamou a atenção o fato de que os cuidados com as unhas e com os cabelos tenham suplantado, no número de citações dos profissionais de enfermagem, aspectos básicos como o cuidado com as mãos. Na higiene corporal do paciente, o banho foi o aspecto considerado mais importante pelas três categorias profissionais; a higiene oral, pelas(os enfermeiras(os e auxiliares de enfermagem; e as unhas, pelas(os enfermeiras(os e técnicas(os de enfermagem.

  2. A coprecipitation technique to prepare NaNbO3 and NaTaO3

    Indian Academy of Sciences (India)

    Unknown

    (V) oxide, tantalum(V) oxide, sodium hydroxide, ethyl alcohol, am- monium carbonate and standard ammonia solution were used and all the starting materials were of AR grade. (Loba chemie). A stoichiometric amount of NaOH was dissolved ...

  3. A capoeira na escola e na Educação Física

    Directory of Open Access Journals (Sweden)

    Vinicius Thiago Melo

    2012-05-01

    Full Text Available http://dx.doi.org/10.5007/2175-8042.2011v23n37p190 Este é um ensaio de revisão bibliográfica que aborda a temática da capoeira na Escola e na Educação Física. A análise de alguns documentos oficiais demonstra que a capoeira estabelece relações concretas com a questão da educação das relações étnico-raciais e com a disciplina Educação Física. No entanto, verifica-se que nem sempre esta modalidade é reconhecida pelas suas possibilidades de participação no processo educativo, mas sim, em uma perspectiva secundária de compensação das tensões da sala de aula e auxílio no controle do comportamento e disciplina dos alunos. Assim, procurou-se refletir e fazer alguns apontamentos sobre o modo pelo qual esta prática cultural tem sido tratada na escola e na Educação Física.

  4. High-temperature phases of NaNbO3 and NaTaO3

    International Nuclear Information System (INIS)

    Darlington, C.N.W.

    1999-01-01

    The high-temperature phases of the perovskites sodium niobate, NaNbO 3 , and sodium tantalate, NaTaO 3 , have been re-examined using the high-resolution powder diffractometer HRPD at the ISIS neutron spallation source; the two materials show the same sequence of phases with tilted octahedra. Diffraction patterns were measured every 5 K allowing structural changes with temperature within a single phase to be determined for the first time. Previous structure determinations within one phase had been performed at a single temperature only. The octahedra are tilted about pseudocubic left angle 100 right angle directions and are also deformed; the magnitude of the deformation is shown to be proportional to the square of the angle of tilt as expected from a phenomenological theory applied to such transitions. The structures of NaNbO 3 between 753 and 793 K and of NaTaO 3 below 758 K are not as reported in the literature. (orig.)

  5. Na-K-Interdiffusion in Alkali Feldspars

    Science.gov (United States)

    Schaeffer, A.-K.; Petrishcheva, E.; Rhede, D.; Abart, R.

    2012-04-01

    Exchange experiments between crystallographically oriented plates of gem-quality alkali feldspar (XOr 0.85) with NaCl/KCl melts have been conducted at 850° and 920° C. The melt composition was varied systematically between XKCl 0.6 and 1 to induce a shift of the feldspar composition towards more Na-rich as well as K-rich compositions (XOr 0.74 to 1). We applied 40-times molar excess of cations in the melt to ensure constant concentration boundary conditions for cation exchange. Depending on the direction of the composition shift diffusion profiles with different geometries develop. After a shift towards more K-rich compositions the diffusion profile shows two plateaus representing the unexchanged core and the exchanged rim in equilibrium with the melt, respectively. The exchange front between the two plateaus has an inflection point and propagates through the crystal with t1/2. Its width depends on the composition difference between the exchanged and unexchanged domains of the grain as well as crystallographic direction. The profiles that develop during a shift towards more Na-rich compositions lack an inflection point. If XOr is shifted by more than 10 mole-% crack systems begin to develop due to composition strain associated with the substitution of K+ by the smaller Na+ion. While the propagation rate of the fronts is roughly equal in all crystallographic directions, the profiles measured in the direction normal to (001) are always narrower than those normal to (010). This indicates a marked anisotropy in interdiffusion which appears fastest in the direction perpendicular to (001), i.e. c*. The observed geometry of the diffusion fronts can be explained by a composition dependence of the interdiffusion coefficient. This dependence was first described by Christoffersen et al. (1983) but these authors used a different experimental setup and only had reliable data for intermediate compositions. From our data we could extract the interdiffusion coefficient for high

  6. Efeito do plasma de oxigênio na dentina previamente exposta ao NaOCl

    Directory of Open Access Journals (Sweden)

    Maíra do PRADO

    Full Text Available Resumo Introdução O tratamento de plasma é uma tecnologia eficaz que pode manter as propriedades internas dos materiais inalteradas após o tratamento, modificando apenas a superfície. Objetivo Avaliar o efeito do plasma de oxigênio na dentina previamente exposta ao NaOCl 6%. Material e método Foram utilizados 60 incisivos bovinos. A coroa foi removida, a raiz foi dividida e as faces planificadas, totalizando 120 segmentos referentes ao terço cervical. As amostras foram divididas em dois grupos: controle (imersa em NaOCl 6%, lavada com água destilada, seca, imersa em EDTA 17%, lavada e seca e plasma de oxigênio (após tratamento descrito no grupo controle, plasma de oxigênio foi aplicado por 30 s. As amostras foram avaliadas qualitativamente em relação à topografia por microscopia eletrônica de varredura, utilizando-se microfotografias com ampliação de 1.000×. O goniômetro Ramé-hart foi utilizado para a mensuração do ângulo de contato entre as superfícies e as seguintes soluções foram utilizadas: água, etilenoglicol e di-iodometano. Em seguida, a energia de superfície, representada pelas componentes polar e dispersiva, foi calculada. Avaliou-se também o escoamento dos cimentos Pulp Canal Sealer EWT (PCS e Real Sal SE (RS na superfície dentinária. Os dados foram analisados estatisticamente utilizando os testes Kruskal-Wallis e Mann-Whitney U (p<0,05. Resultado O tratamento com plasma levou à formação de uma camada semelhante à smear layer na superfície dentinária. Este tratamento levou a um aumento da energia de superfície e da componente polar, favorecendo a hidrofilicidade da superfície. Entretanto, desfavoreceu o escoamento do cimento PCS e não influenciou no escoamento do cimento RS. Conclusão O plasma de oxigênio ocasionou mudanças topográficas na superfície dentinária, favorecendo a hidrofilicidade desta. Contudo, não favoreceu o escoamento dos cimentos endodônticos na dentina.

  7. Diffusion of Na+ AND Sr2+ tracers in compacted, saturated Na-bentonite: a predictive model

    International Nuclear Information System (INIS)

    Bourg, I.C.; Sposito, G.; Bourg, A.C.M.

    2005-01-01

    Full text of publication follows: A key characteristic of the porosity of compacted bentonite is that it is composed not only of macro- and meso-pores, but also of nanometer-thin interlayer pores. The interlayer pore water is in intimate contact with the negatively charged clay, and has a high cation concentration. Anions are strongly excluded from this region. The fluids present in interlayer pores and in the larger pores of compacted, saturated bentonite or montmorillonite have been described as distinct aqueous phases. This distinction has allowed successful explanations of, e.g., chemo-mechanical coupling in clays. However, it is not used in current models of the diffusion of tracers in compacted, saturated bentonite. We have developed a model of the diffusion of tracers in compacted, saturated Na-bentonite in which the interlayers and larger pores are described as parallel diffusion paths [1]. This model has allowed us to successfully describe the mean principal value of the apparent diffusivity tensor of water tracers in several one-dimensionally compacted, saturated Na-bentonites, in a broad range of partial montmorillonite dry density, using the direction-averaged tortuosity (τ = 1.9 ± 0.6) as a single fitted parameter [2]. We report on the application of the same model to the diffusion of Na + and Sr 2+ tracers in compacted, saturated Na-bentonite. Our model successfully predicts the ratio of the apparent diffusivities of cationic and water tracers, with no fitted parameters, as a function of both partial montmorillonite dry density and ionic strength. Furthermore, we show that a relation between the activation energy of diffusion of Na+ tracers and the partial montmorillonite dry density of Na-bentonite can be derived from our model, and can be fit to experimental data. [1] Diffusion of Water and Inorganic Ions in Compacted Saturated Bentonite, I.C. Bourg (2004), Ph.D. thesis, University of California, Berkeley; [2] Diffusion of Water Tracers in

  8. Stimulation of Na+/K+ ATPase activity and Na+ coupled glucose transport by β-catenin

    International Nuclear Information System (INIS)

    Sopjani, Mentor; Alesutan, Ioana; Wilmes, Jan; Dermaku-Sopjani, Miribane; Lam, Rebecca S.; Koutsouki, Evgenia; Jakupi, Muharrem; Foeller, Michael; Lang, Florian

    2010-01-01

    Research highlights: → The oncogenic transcription factor β-catenin stimulates the Na + /K + -ATPase. → β-Catenin stimulates SGLT1 dependent Na + , glucose cotransport. → The effects are independent of transcription. → β-Catenin sensitive transport may contribute to properties of proliferating cells. -- Abstract: β-Catenin is a multifunctional protein stimulating as oncogenic transcription factor several genes important for cell proliferation. β-Catenin-regulated genes include the serum- and glucocorticoid-inducible kinase SGK1, which is known to stimulate a variety of transport systems. The present study explored the possibility that β-catenin influences membrane transport. To this end, β-catenin was expressed in Xenopus oocytes with or without SGLT1 and electrogenic transport determined by dual electrode voltage clamp. As a result, expression of β-catenin significantly enhanced the ouabain-sensitive current of the endogeneous Na + /K + -ATPase. Inhibition of vesicle trafficking by brefeldin A revealed that the stimulatory effect of β-catenin on the endogenous Na + /K + -ATPase was not due to enhanced stability of the pump protein in the cell membrane. Expression of β-catenin further enhanced glucose-induced current (Ig) in SGLT1-expressing oocytes. In the absence of SGLT1 Ig was negligible irrespective of β-catenin expression. The stimulating effect of β-catenin on both Na + /K + ATPase and SGLT1 activity was observed even in the presence of actinomycin D, an inhibitor of transcription. The experiments disclose a completely novel function of β-catenin, i.e. the regulation of transport.

  9. Recent results and prospects for NA62 experiment

    Science.gov (United States)

    Martellotti, Silvia; Aglieri Rinella, G.; Aliberti, R.; Ambrosino, F.; Ammendola, R.; Angelucci, B.; Antonelli, A.; Anzivino, G.; Arcidiacono, R.; Azhinenko, I.; Balev, S.; Barbanera, M.; Bendotti, J.; Biagioni, A.; Bician, L.; Biino, C.; Bizzeti, A.; Blazek, T.; Blik, A.; Bloch-Devaux, B.; Bolotov, V.; Bonaiuto, V.; Boretto, M.; Bragadireanu, M.; Britton, D.; Britvich, G.; Brunetti, M. B.; Bryman, D.; Bucci, F.; Butin, F.; Capitolo, E.; Capoccia, C.; Capussela, T.; Cassese, A.; Catinaccio, A.; Cecchetti, A.; Ceccucci, A.; Cenci, P.; Cerny, V.; Cerri, C.; Checcucci, B.; Chikilev, O.; Chiozzi, S.; Ciaranfi, R.; Collazuol, G.; Conovaloff, A.; Cooke, P.; Cooper, P.; Corradi, G.; Cortina Gil, E.; Costantini, F.; Cotorobai, F.; Cotta Ramusino, A.; Coward, D.; D'Agostini, G.; Dainton, J.; Dalpiaz, P.; Danielsson, H.; Degrange, J.; De Simone, N.; Di Filippo, D.; Di Lella, L.; Di Lorenzo, S.; Dixon, N.; Doble, N.; Dobrich, B.; Duk, V.; Elsha, V.; Engelfried, J.; Enik, T.; Estrada, N.; Falaleev, V.; Fantechi, R.; Fascianelli, V.; Federici, L.; Fedotov, S.; Fiorini, M.; Fry, J.; Fu, J.; Fucci, A.; Fulton, L.; Gallorini, S.; Galeotti, S.; Gamberini, E.; Gatignon, L.; Georgiev, G.; Gianoli, A.; Giorgi, M.; Giudici, S.; Glonti, L.; Goncalves Martins, A.; Gonnella, F.; Goudzovski, E.; Guida, R.; Gushchin, E.; Hahn, F.; Hallgren, B.; Heath, H.; Herman, F.; Husek, T.; Hutanu, O.; Hutchcroft, D.; Iacobuzio, L.; Iacopini, E.; Imbergamo, E.; Jamet, O.; Jarron, P.; Jones, E.; Kampf, K.; Kaplon, J.; Kekelidze, V.; Kholodenko, S.; Khoriauli, G.; Khotyantsev, A.; Khudyakov, A.; Kiryushin, Yu.; Kleimenova, A.; Kleinknecht, K.; Kluge, A.; Koval, M.; Kozhuharov, V.; Krivda, M.; Kucerova, Z.; Kudenko, Y.; Kunze, J.; Lamanna, G.; Latino, G.; Lazzeroni, C.; Lehmann-Miotto, G.; Lenci, R.; Lenti, M.; Leonardi, E.; Lichard, P.; Lietava, R.; Litov, L.; Lollini, R.; Lomidze, D.; Lonardo, A.; Lupi, M.; Lurkin, N.; McCormick, K.; Madigozhin, D.; Maire, G.; Mandeiro, C.; Mannelli, I.; Mannocchi, G.; Mapelli, A.; Marchetto, F.; Marchevski, R.; Martellotti, S.; Massarotti, P.; Massri, K.; Matak, P.; Maurice, E.; Mefodev, A.; Menichetti, E.; Minucci, E.; Mirra, M.; Misheva, M.; Molokanova, N.; Morant, J.; Morel, M.; Moulson, M.; Movchan, S.; Munday, D.; Napolitano, M.; Neri, I.; Newson, F.; Norton, A.; Noy, M.; Nuessle, G.; Numao, T.; Obraztsov, V.; Ostankov, A.; Padolski, S.; Page, R.; Palladino, V.; Paoluzzi, G.; Parkinson, C.; Pedreschi, E.; Pepe, M.; Perez Gomez, F.; Perrin-Terrin, M.; Peruzzo, L.; Petrov, P.; Petrucci, F.; Piandani, R.; Piccini, M.; Pietreanu, D.; Pinzino, J.; Polenkevich, I.; Pontisso, L.; Potrebenikov, Yu.; Protopopescu, D.; Raffaelli, F.; Raggi, M.; Riedler, P.; Romano, A.; Rubin, P.; Ruggiero, G.; Russo, V.; Ryjov, V.; Salamon, A.; Salina, G.; Samsonov, V.; Santoni, C.; Saracino, G.; Sargeni, F.; Semenov, V.; Sergi, A.; Serra, M.; Shaikhiev, A.; Shkarovskiy, S.; Skillicorn, I.; Soldi, D.; Sotnikov, A.; Sougonyaev, V.; Sozzi, M.; Spadaro, T.; Spinella, F.; Staley, R.; Sturgess, A.; Sutcliffe, P.; Szilasi, N.; Tagnani, D.; Trilov, S.; Valdata-Nappi, M.; Valente, P.; Vasile, M.; Vassilieva, T.; Velghe, B.; Veltri, M.; Venditti, S.; Vicini, P.; Volpe, R.; Vormstein, M.; Wahl, H.; Wanke, R.; Wertelaers, P.; Winhart, A.; Winston, R.; Wrona, B.; Yushchenko, O.; Zamkovsky, M.; Zinchenko, A.; NA62 Collaboration

    2017-04-01

    The K+ →π+ ν ν ‾ decay is theoretically one of the cleanest meson decays and so a good place to look for indirect effects of new physics complementary to LHC searches. The NA62 experiment at CERN is designed to measure the branching ratio of this decay with 10% precision. NA62 was commissioned in October 2014, took data in pilot runs in 2014 and 2015. The NA62 experimental setup is illustrated and data quality is reported.

  10. RAZVOJ APLIKACIJE PRETOČNEGA VIDEA NA MOBILNEM TELEFONU

    OpenAIRE

    Horvat, Jernej

    2012-01-01

    Diplomsko delo obravnava prenos video signala iz mobilnega telefona na TV. Prenos poteka preko Wi-Fi omrežja. Na mobilnem telefonu je nameščena ustrezna Android aplikacija, ki omogoča direkten prenos video signala in nalaganje na TV sprejemnik. Pomemben dejavnik, ki prispeva, da je ta proces mogoč, je sistem IMS (IP multimedijski podsistem), ki predstavlja omrežja naslednje generacije.

  11. Transcriptional regulators of Na, K-ATPase subunits

    OpenAIRE

    Zhiqin eLi; Sigrid A Langhans

    2015-01-01

    The Na,K-ATPase classically serves as an ion pump creating an electrochemical gradient across the plasma membrane that is essential for transepithelial transport, nutrient uptake and membrane potential. In addition, Na,K-ATPase also functions as a receptor, a signal transducer and a cell adhesion molecule. With such diverse roles, it is understandable that the Na,K-ATPase subunits, the catalytic alpha-subunit, the beta-subunit and the FXYD proteins, are controlled extensively during developme...

  12. Sociologia na complexidade Sociology in complexity

    Directory of Open Access Journals (Sweden)

    Gilson Lima

    2006-06-01

    Full Text Available O artigo se propõe a fazer uma introdução didática e informativa e, ao mesmo tempo, aprofundada sobre as conseqüências da emergência do paradigma da complexidade para a Sociologia. No desenrolar da narrativa, faz comparações, o que permite ao leitor não familiarizado com a temática da ciência identificar as diferenças macroparadigmáticas pré-modernas, da modernidade simples e da emergência do paradigma da complexidade. Define e exemplifica, sempre que possível, os termos, afirmações e princípios significativos para uma melhor compreensão do tema. Faz, também, inúmeras indicações, no interior da narrativa, de autores e obras, para que aqueles que desejarem continuar, possam mergulhar mais intensamente nos caminhos da sociologia da complexidade. O artigo inicia com uma introdução que define, a partir de Thomas Kuhn, o conceito de paradigma. A seguir, desenvolve de modo comparado, os princípios mais importantes do paradigma da complexidade. E, por fim, chama a atenção para alguns desafios da Sociologia na complexidade, alertando para os riscos da paralisação da complexidade na difícil tarefa de religarmos os saberes diante da hiperespecialização presente na crise do paradigma da modernidade simples.The article is a simultaneously didactic and informative deep introduction on the emergence of the paradigm of complexity for sociology. Along the narrative, we make comparisons, which allows the reader who is not familiar with the themes of science to identify the macro-paradigmatic pre-modern differences from simple modernity and the emergence of the paradigm of complexity. Whenever it is possible, we define and exemplify the terms, assertions, and principles that are significant for an understanding of the theme. We have also made numerous indications of authors and works within the narrative, thus those willing might take a deeper dive in the pathways of sociology of complexity. The article starts with an

  13. RAHNER NA BERLINDA PÓS-CONCILIAR

    Directory of Open Access Journals (Sweden)

    Luciano Campos Lavall

    2004-01-01

    Full Text Available O artigo analisa algumas críticas negativas feitas ao pensamento teológico de Karl Rahner, após sua morte, que tentam desqualificar a sua importância para a ortodoxia católica e o seu distanciamento dos fundamentos do Concílio Vaticano II. Na discussão, enfocada sobretudo no ponto de vista da eclesiologia rahneriana, retoma importante entrevista do mesmo, no ano de sua morte, na qual aparece a sua preocupação com as chances futuras da Igreja, sobretudo na Europa Ocidental, a partir da qual abordam-se as relações entre Cristianismo e Igreja. As estratégias para a organização pastoral do mundo católico são a tônica desta reflexão. Para justificar suas posturas, o artigo termina com uma avaliação global de todo o conjunto teológico de Karl Rahner, redescobrindo nele os pilares mais fundamentais que justificam sua ortodoxia a serviço da fé cristã e católica, mas também a serviço da tomada de consciência de uma fé vivenciada e comprometida por parte da humanidade marcadamente secularizada. ABSTRACT: The article analyses negative criticisms against Rahner’s theological views after his death with the intention of discrediting him and his role in Catholic orthodoxy by distancing him from the fundamentals of Vatican Council II. In the discussion, primarily focused on Rahner’s ecclesiology, the article retakes a significant interview made the same year of Rahner’s death. In this interview his concern for the Church’s future chances, especially regarding Eastern Europe, embarking on relations between Christianity and Church. The strategies for world-wide organization of Catholic ministry predominate this reflection. Justifying its postures, the article concludes with a global evaluation of Rahner’s theology, rediscovering the fundamental pillars which justify his orthodoxy at the service of the Christian and Catholic faith, but also at the service of a conscientious living of a committed faith on behalf of a notably

  14. Characterization of ZnAl cast alloys with Na addition

    Energy Technology Data Exchange (ETDEWEB)

    Gancarz, Tomasz, E-mail: t.gancarz@imim.pl [Institute of Metallurgy and Materials Science, Polish Academy of Sciences, Krakow (Poland); Cempura, Grzegorz [AGH University of Science and Technology, International Centre of Electron Microscopy for Materials Science, Faculty of Metals Engineering and Industrial Computer Science, Krakow (Poland); Skuza, Wojciech [Institute of Metallurgy and Materials Science, Polish Academy of Sciences, Krakow (Poland)

    2016-01-15

    This study was aimed at evaluating the microstructural change and thermal, electrical and mechanical properties with the addition of Na to eutectic ZnAl alloys. Solders based on eutectic ZnAl containing 0.2 to 3.0 (wt.%) of Na were developed for high temperature solder. Differential scanning calorimetry (DSC) measurements were performed to determine the melting temperatures of the alloys. Thermal linear expansion and electrical resistivity measurements were performed over − 50 °C to 300 °C and 30 °C to 300 °C temperature ranges, respectively. The microstructure of the specimens was analyzed using scanning (SEM) and transmission electron microscopy (TEM) techniques. Chemical microanalysis was performed by energy-dispersive X-ray spectroscopy (EDS) on SEM and TEM. The precipitates of NaZn{sub 13} were confirmed by X-ray diffraction (XRD) measurements and selected area electron diffraction (SAED) techniques. The addition of Na to eutectic ZnAl alloy increased the electrical resistivity and reduced the coefficient of thermal expansion; however, the melting point did not change. The mechanical properties, strain and microhardness increased with Na content in alloys. - Highlights: • High temperature soldering materials of ZnAl with Na were designed and characterized. • Precipitates of NaZn{sub 13}were observed and confirmed using TEM and XRD. • Addition of Na to eutectic ZnAl cussed increased mechanical properties. • NaZn{sub 13} caused increased electrical resistivity and microhardness, and reduced the CTE.

  15. Dejavniki psihološkega nasilja na delovnem mestu

    OpenAIRE

    Ilc, Teja

    2011-01-01

    Raziskave na področju delovnih razmer kažejo, da je danes pereč problem ravno psihološko nasilje na delovnem mestu. Posebna oblika psihološkega nasilja na delovnem mestu je mobing, s katerim se v praksi srečujemo vsak dan, vendar se ga pogosto ne zavedamo. Namen magistrske naloge je pojasniti pojem in pomen mobinga v delovnih organizacijah, poiskati možne vzroke in posledice, ki vplivajo na ta pojav, ter predlagati rešitve. Poznavanje mehanizmov, ki povzročajo mobing, njegovih vzrokov in...

  16. VLOGA ETIKE PRI PREPREČEVANJU NADLEGOVANJA NA DELOVNEM MESTU

    OpenAIRE

    Sambolec, Katja

    2013-01-01

    V diplomskem seminarju smo obravnavali temo z naslovom Vpliv etike pri preprečevanju nadlegovanja na delovnem mestu. Tema o nadlegovanju na delovnem mestu, je aktualna že desetletja in glede na gospodarsko krizo, ki ji še ni videti konca, je aktualna še danes. Zaradi prenasičenosti trga s ponudniki iste branže, se posledično v posameznih podjetjih izvajajo pritiski na zaposlene, ki v različnih situacijah vodijo do nadlegovanja. Pri pisanju diplomskega seminarja smo se najprej osredotoči...

  17. Influenza virus neuraminidase (NA): a target for antivirals and vaccines.

    Science.gov (United States)

    Jagadesh, Anitha; Salam, Abdul Ajees Abdul; Mudgal, Piya Paul; Arunkumar, Govindakarnavar

    2016-08-01

    Influenza, the most common infectious disease, poses a great threat to human health because of its highly contagious nature and fast transmissibility, often leading to high morbidity and mortality. Effective vaccination strategies may aid in the prevention and control of recurring epidemics and pandemics associated with this infectious disease. However, antigenic shifts and drifts are major concerns with influenza virus, requiring effective global monitoring and updating of vaccines. Current vaccines are standardized primarily based on the amount of hemagglutinin, a major surface antigen, which chiefly constitutes these preparations along with the varying amounts of neuraminidase (NA). Anti-influenza drugs targeting the active site of NA have been in use for more than a decade now. However, NA has not been approved as an effective antigenic component of the influenza vaccine because of standardization issues. Although some studies have suggested that NA antibodies are able to reduce the severity of the disease and induce a long-term and cross-protective immunity, a few major scientific issues need to be addressed prior to launching NA-based vaccines. Interestingly, an increasing number of studies have shown NA to be a promising target for future influenza vaccines. This review is an attempt to consolidate studies that reflect the strength of NA as a suitable vaccine target. The studies discussed in this article highlight NA as a potential influenza vaccine candidate and support taking the process of developing NA vaccines to the next stage.

  18. O grotesco na imagem publicitária

    OpenAIRE

    Silva, Maria João Barros

    2013-01-01

    O significado da palavra grotesco teve um começo puramente artístico numa descoberta, de imagens de figuras humanas deformadas e alteradas. No entanto, este foi evoluindo e adotando novos significados mais amplos e concretos na atualidade. É possível encontrar vários exemplos do grotesco em várias plataformas, como no cinema, na televisão e na literatura. Neste sentido, para se poder proceder ao estudo desta temática é fundamental a conquista do conhecimento sobre o estatuto do grotesco na pu...

  19. DISKRIMINACIJA PRI ZAPOSLOVANJU IN DELU NA PODLAGI SPOLNE USMERJENOSTI

    OpenAIRE

    Markovič, Polona

    2012-01-01

    Ustavno zagotovljena pravica do enakosti, brez kakršnegakoli razlikovanja na podlagi osebnih okoliščin, predstavlja eno izmed temeljnih človekovih pravic. Za zagotavljanje enakega obravnavanja posameznikov in različnih skupin oseb na vseh področjih družbenega življenja je neizogibno potrebna natančna zakonska opredelitev varstva pred diskriminacijo. Prepoved diskriminacije je pravno regulirana v določilih mnogih dokumentov, sprejetih na mednarodni in nacionalni ravni. Diskriminacijo lahko naj...

  20. Cafeína e desempenho em atividade de endurance?

    OpenAIRE

    Souza Junior, Tácito Pessoa de; Capitani, Caroline Dario; Loturco Filho, Irineu; Viveiros, Luis; Aoki, Marcelo Saldanha

    2012-01-01

    A cafeína é frequentemente consumida por atletas, por causa dos seus possíveis efeitos ergogênicos. É preconizado que a cafeína maximize a performance por agir, independentemente, ou concomitamente, através de 3 mecanismos: 1) aumento da mobilização do cálcio intracelular, 2) aumento na oxidação de ácidos graxos livres e 3) antagonista do receptor de adenosina no sistema nervoso central. Estudos iniciais sugeriram que o efeito ergogênico da cafeína estava relacionado ao aumento da oxidaçã...

  1. Transcriptional regulators of Na, K-ATPase subunits

    Directory of Open Access Journals (Sweden)

    Zhiqin eLi

    2015-10-01

    Full Text Available The Na,K-ATPase classically serves as an ion pump creating an electrochemical gradient across the plasma membrane that is essential for transepithelial transport, nutrient uptake and membrane potential. In addition, Na,K-ATPase also functions as a receptor, a signal transducer and a cell adhesion molecule. With such diverse roles, it is understandable that the Na,K-ATPase subunits, the catalytic alpha-subunit, the beta-subunit and the FXYD proteins, are controlled extensively during development and to accommodate physiological needs. The spatial and temporal expression of Na,K-ATPase is partially regulated at the transcriptional level. Numerous transcription factors, hormones, growth factors, lipids and extracellular stimuli modulate the transcription of the Na,K-ATPase subunits. Moreover, epigenetic mechanisms also contribute to the regulation of Na,K-ATPase expression. With the ever growing knowledge about diseases associated with the malfunction of Na,K-ATPase, this review aims at summarizing the best-characterized transcription regulators that modulate Na,K-ATPase subunit levels. As abnormal expression of Na,K-ATPase subunits have been observed in many carcinoma, we will also discuss transcription factors that are associated with epithelial-to-mesenchymal transition, a crucial step in the progression of many tumors to malignant disease.

  2. Cathode Dependence of Liquid-Alloy Na-K Anodes.

    Science.gov (United States)

    Xue, Leigang; Gao, Hongcai; Li, Yutao; Goodenough, John B

    2018-03-07

    Alkali ions can be plated dendrite-free into a liquid alkali-metal anode. Commercialized Na-S battery technology operates above 300 °C. A low-cost Na-K alloy is liquid at 25 °C from 9.2 to 58.2 wt% of sodium; sodium and/or potassium can be plated dendrite-free in the liquid range at room temperature. The co-existence of two alkali metals in an anode raises a question: whether the liquid Na-K alloy acts as a Na or a K anode. Here we show the alkali-metal that is stripped from the liquid Na-K anode is dependent on the preference of the cathode host. It acts as the anode of a sodium rechargeable cell if the cathode host structure selectively accepts only Na + ions; as the anode of a potassium rechargeable cell if the cathode accepts K + ions in preference to Na + ions. This dual-anode behavior means the liquid Na-K alkali-alloy can be applied as a dendrite-free anode in Na-metal batteries as well as K-metal batteries.

  3. Scintillation efficiency measurement of Na recoils in NaI(Tl) below the DAMA/LIBRA energy threshold

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Jingke; Shields, Emily; Calaprice, Frank; Westerdale, Shawn; Froborg, Francis; Suerfu, Burkhant; Alexander, Thomas; Aprahamian, Ani; Back, Henning O.; Casarella, Clark; Fang, Xiao; Gupta, Yogesh K.; Ianni, Aldo; Lamere, Edward; Lippincott, W. Hugh; Liu, Qian; Lyons, Stephanie; Siegl, Kevin; Smith, Mallory; Tan, Wanpeng; Kolk, Bryant Vande

    2015-07-01

    The dark matter interpretation of the DAMA modulation signal depends on the NaI(Tl) scintillation efficiency of nuclear recoils. Previous measurements for Na recoils have large discrepancies, especially in the DAMA/LIBRA modulation energy region. We report a quenching effect measurement of Na recoils in NaI(Tl) from 3 to 52 keVnr, covering the whole DAMA/LIBRA energy region for dark matter-Na scattering interpretations. By using a low-energy, pulsed neutron beam, a double time-of-flight technique, and pulse-shape discrimination methods, we obtained the most accurate measurement of this kind for NaI(Tl) to date. The results differ significantly from the DAMA reported values at low energies but fall between the other previous measurements. We present the implications of the new quenching results for the dark matter interpretation of the DAMA modulation signal.

  4. Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy.

    Science.gov (United States)

    Felippe Gonçalves-de-Albuquerque, Cassiano; Ribeiro Silva, Adriana; Ignácio da Silva, Camila; Caire Castro-Faria-Neto, Hugo; Burth, Patrícia

    2017-04-21

    Lung cancer is a leading cause of global cancer deaths. Na/K-ATPase has been studied as a target for cancer treatment. Cardiotonic steroids (CS) trigger intracellular signalling upon binding to Na/K-ATPase. Normal lung and tumour cells frequently express different pump isoforms. Thus, Na/K-ATPase is a powerful target for lung cancer treatment. Drugs targeting Na/K-ATPase may induce apoptosis and autophagy in transformed cells. We argue that Na/K-ATPase has a role as a potential target in chemotherapy in lung cancer treatment. We discuss the effects of Na/K-ATPase ligands and molecular pathways inducing deleterious effects on lung cancer cells, especially those leading to apoptosis and autophagy.

  5. Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy

    Directory of Open Access Journals (Sweden)

    Cassiano Felippe Gonçalves-de-Albuquerque

    2017-04-01

    Full Text Available Lung cancer is a leading cause of global cancer deaths. Na/K-ATPase has been studied as a target for cancer treatment. Cardiotonic steroids (CS trigger intracellular signalling upon binding to Na/K-ATPase. Normal lung and tumour cells frequently express different pump isoforms. Thus, Na/K-ATPase is a powerful target for lung cancer treatment. Drugs targeting Na/K-ATPase may induce apoptosis and autophagy in transformed cells. We argue that Na/K-ATPase has a role as a potential target in chemotherapy in lung cancer treatment. We discuss the effects of Na/K-ATPase ligands and molecular pathways inducing deleterious effects on lung cancer cells, especially those leading to apoptosis and autophagy.

  6. The NA49 large acceptance hadron detector

    CERN Document Server

    Afanasiev, S V; Appelshäuser, H; Bächler, J; Barna, D; Barnby, L S; Bartke, Jerzy; Barton, R A; Betev, L; Bialkowska, H; Bieser, F; Billmeier, A; Blyth, C O; Böck, R K; Bormann, C; Bracinik, J; Brady, F P; Brockmann, R; Brun, R; Buncic, P; Caines, H L; Cebra, D; Cooper, G E; Cramer, J G; Csató, P; Cyprian, M; Dunn, J; Eckardt, V; Eckhardt, F; Empl, T; Eschke, J; Ferguson, M I; Fessler, H; Fischer, H G; Flierl, D; Fodor, Z; Frankenfeld, Ulrich; Foka, P Y; Freund, P; Friese, V; Ftácnik, J; Fuchs, M; Gabler, F; Gál, J; Ganz, R E; Gazdzicki, M; Gladysz-Dziadus, E; Grebieszkow, J; Günther, J; Harris, J W; Hegyi, S; Henkel, T; Hill, L A; Hlinka, V; Huang, I; Hümmler, H; Igo, G; Irmscher, D; Ivanov, M; Janik, R; Jacobs, P; Jones, P G; Kadija, K; Kolesnikov, V I; Kowalski, M; Lasiuk, B; Lévai, Peter; Liebicher, K; Lynen, U; Malakhov, A I; Margetis, S; Markert, C; Marks, C; Mayes, B W; Melkumov, G L; Mock, A; Molnár, J; Nelson, J M; Oldenburg, M; Odyniec, Grazyna Janina; Pálla, G; Panagiotou, A D; Pestov, Yu N; Petridis, A; Pikna, M; Pimpl, W; Pinsky, L; Piper, A; Porter, R J; Poskanzer, A M; Poziombka, S; Prindle, D J; Pühlhofer, F; Rauch, W; Reid, J G; Renfordt, R E; Retyk, W; Ritter, H G; Röhrich, D; Roland, C; Roland, G; Rudolph, H; Rybicki, A; Sammer, T; Sandoval, A; Sann, H; Schäfer, E; Schmidt, R; Schmischke, D; Schmitz, N; Schönfelder, S; Semenov, A Yu; Seyboth, J; Seyboth, P; Seyerlein, J; Siklér, F; Sitár, B; Skrzypczak, E; Squier, G T A; Stelzer, H; Stock, Reinhard; Strmen, P; Ströbele, H; Struck, C; Susa, T; Szarka, I; Szentpétery, I; Szymanski, P; Sziklai, J; Toy, M; Trainor, T A; Trentalange, S; Ullrich, T S; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wang, F; Weerasundara, D D; Wenig, S; Whitten, C; Wieman, H H; Wienold, T; Wood, L; Yates, T A; Zimányi, J; Zhu, X Z; Zybert, R

    1999-01-01

    The NA49 detector is a wide acceptance spectrometer for the study of hadron production in p+p, p+A, and A+A collisions at the CERN SPS. The main components are 4 large volume TPCs for tracking and particle identification via $dE/dx$. TOF scintillator arrays complement particle identification. Calorimeters for transverse energy determination and triggering, a detector for centrality selection in p+A collisions, and beam definition detectors complete the set-up. A description of all detector components is given with emphasis on new technical realizations. Performance and operational experience are discussed in particular with respect to the high track density environment of central Pb+Pb collisions.

  7. Sexo e sexualidade na terceira idade

    OpenAIRE

    Nery, Valeria Alves da Silva; UESB; Valença, Tatiane Dias Casimiro; UESB

    2014-01-01

    Muitos idosos ainda encaram o envelhecer como sinônimo de decadência e isolamento, doenças e peso social, sendo que a sociedade impõe aos idosos, tabus, privando-lhe de re-pensar a sexualidade, o corpo, o prazer, a prática do sexo, levando-os a enfrentar várias dificuldades de adaptação a esse estágio da vida. O objetivo geral deste estudo foi Analisar as percepções sobre sexo e sexualidade na terceira idade. Quanto aos objetivos específicos, busca-se: averiguar se os idosos continuam tendo v...

  8. Bullying: ato esburacado na angústia

    Directory of Open Access Journals (Sweden)

    Maria de Lourdes Soares Ornellas

    2012-04-01

    Full Text Available A noção de afeto está no campo do (desprazer, resultante de uma experiência afetiva de satisfação ou insatisfação, e que se manifesta nas necessidades do sujeito. Pode-se dizer que o afeto envolve a ambivalência de sentimentos, do mais agradável ao mais insuportável, e desempenha um papel estruturante para que o sujeito reencontre sua estrutura psíquica, exercendo uma ação mediadora e decisiva sobre a constituição do sujeito do desejo, orientando o seu projeto de vida, sua profissão, sua opção sexual, etc. Essa ambivalência de afetos deve ser exercitada na educação familiar e escolar, na fala e na escuta que o afeto (desprazeroso tem relevância e parece ser silenciado. O desprazer pode ser escandido pelos sintomas medo, depressão, irritabilidade, ansiedade, humilhação. Assim posto o bullying é também conhecido como a síndrome da humilhação. O objetivo da humilhação é a tentativa de destruição do sujeito; a perda da identificação revela um fantasma, na medida em que própria vítima se sente culpada por sofrer ou por estar sofrendo um ato esburacado porque uma das peças não é encontrada e, em lugar do encaixe, o que se mostra é um buraco, o que provoca a angústia entre quem perde e aquele que ganha. ABSTRACT: The notion of affect is thus in the field of (dis pleasure, resulting from an affective experience of satisfaction or dissatisfaction, and that manifests itself on the needs of the subject. You could say that the affection involves the ambivalence of feelings, the more enjoyable the more unbearable, and plays a structural role for the subject to rediscover his psychic structure, exerting a mediator and decisive action on the constitution of the subject of desire, directing the its design life, your profession, your sexual orientation, etc.. This ambivalence of feelings should be exercised in family education and school, talking and listening that affect (dis pleasure is relevant and appears to be

  9. Redes sociais na internet: Sociabilidades emergentes

    OpenAIRE

    Amaral, Inês

    2016-01-01

    Na actual era da cultura digital é imperativo identificar e compreender os tipos de sociabilidade que emergem das novas práticas e relações que ocorrem no ciberespaço, para que seja possível teorizar sobre realidades sociais que são desenhadas em torno da apropriação do conteúdo e materializadas em plataformas que se assumem como o termómetro de uma sociedade sem determinismo geográfico. A sociabilização em contexto digital reporta-se ao princípio de que um mundo de informação (conteúdos, ...

  10. O retorno do religioso na contemporaneidade

    Directory of Open Access Journals (Sweden)

    Tiago Ribeiro Nunes

    2008-12-01

    Full Text Available O presente trabalho pretende analisar os novos modos de relação, entre a civilização e o sagrado, que emergem no contexto da contemporaneidade. Partindo principalmente das formulações freudianas e lacanianas sobre o tema, nosso objetivo primordial ao longo deste artigo é estabelecer parâmetros para compreender a ocorrência do "retorno ao sagrado no exato momento em que a humanidade enfrenta crises cada vez mais profundas e permanentes. Tal empreendimento nos permitirá verificar até que ponto o fortalecimento dos movimentos religiosos pode ser considerado como uma das conseqüências da queda dos referenciais que se realiza na contemporaneidade.

  11. Topicos na classe dos grafos clique

    OpenAIRE

    Luis Arturo Perez Lozada

    1996-01-01

    Resumo: Uma dique de um grafo G é um conjunto de vértices que induz um subgrafo completo maximal de G. O grafo dique K(G) de um grafo G é o grafo interseção das diques de G. Indutivamente define-se o i-ésimo grafo dique iterado de G como Ki(G) = K(Ki-l(G)). Apresenta-se de maneira organizada uma compilação de pesquisas realizadas nos últimos anos a respeito de diversos tópicos na dasse dos grafos dique, entre eles: o estudo das propriedades dos grafos dique de conhecidas dasses de grafos; a c...

  12. A TATUAGEM: NO CORPO E NA ESCRITA

    OpenAIRE

    Coito, Roselene de Fátima

    2007-01-01

    Entendendo a narrativa como uma negociação de sentidos, faremos uma reflexão sobre identidade a partir de marcas. A identidade na construção discursiva, no conto A hora e a vez de Augusto Matraga, de Guimarães Rosa, vale-se de dois olhares nesta reflexão: da marca tatuada no corpo de Matraga e de Matraga como marca circular da narrativa, pois Matraga é a marca da brasa que queima com ferro o corpo e também a página em branco tatuada pela escrita, o que faz do corpo, a escrita e da escrita, o ...

  13. Solubility of NaNd(CO3)2.6H2O(c) in concentrated Na2CO3 and NaHCO3 solutions

    International Nuclear Information System (INIS)

    Rao, L.; Rai, D.; Felmy, A.R.; Fulton, R.W.; Novak, C.F.

    1996-01-01

    NaNd(CO 3 ) 2 x 6 H 2 O(c) was identified to be the final equilibrium solid phase in suspensions containing concentrated sodium carbonate (0.1 to 2.0 M) and sodium bicarbonate (0.1 to 1.0 M), with either NaNd(CO 3 ) 2 x 6 H 2 O(c) or Nd 2 (CO 3 ) 3 x xH 2 O(s) as initial solids. A thermodynamic model, based on Pitzer's specific into-interaction approach, was developed to interpret the solubility of NaNd(CO 3 ) 2 x 6 H 2 O(c) as functions of sodium carbonate and sodium bicarbonate concentrations. In this model, the solubility data of NaNd(CO 3 ) 2 x 6 H 2 O(c) were explained by assuming the formation of NdCO 3 + , Nd(CO 3 ) 2 - and Nd(CO 3 ) 3 3- species and invoking the specific ion interactions between Na + and Nd(CO 3 ) 3 3- . Ion interaction parameters for Na + -Nd(CO 3 ) 3 3- were developed to fit the solubility data. Based on the model calculations, Nd(CO 3 ) 3 3- was the predominant aqueous neodymium species in 0.1 to 2 M sodium carbonate and 0.1 to 1 M sodium bicarbonate solutions. The logarithm of the NaNd(CO 3 ) 2 x 6 H 2 O solubility product (NaNd(CO 3 ) 2 x 6 H 2 O(c)=Na + +Nd 3+ +2 CO 3 2- +6 H 2 O) was calculated to be -21.39. This model also provided satisfactory interpretation of the solubility data of the analogous Am(III) system in less concentrated carbonate and bicarbonate solutions. (orig.)

  14. Instrumental neutron-activation analysis applications in the age dynamics assessment of Ca, Cl, K, Mg. Mn, Na, P, and Sr contents in the human cortical bone

    International Nuclear Information System (INIS)

    Zaichick, V.

    2003-01-01

    Full text: Senile osteoporosis and particularly osteoporosis among postmenopausal women represents an urgent problem of modern medicine. One of the main osteoporosis symptoms is a decrease in both bone mineral density and subsequent bone strength. The upper extremity of the femur in humans is a particularly vulnerable section of the skeleton, being subject to fracture and necrosis and to destruction of its cartilage. Iliac crest biopsies are commonly taken clinically on patients. It is known that the control of the mineral component providing bone strength is a good indicator to detect bone diseases like osteoporosis. Despite this, changes of chemical element contents occurring with age in the femoral head and the iliac crest of female and male separately have been little studied, but in iliac cortical bone have not been studied at all. The effect of age and sex on chemical element contents in intact cortical bone of femoral neck and iliac crest of 81 relatively healthy 15-55 years old women (n=36) and men (n=45) was investigated. All subjects had died suddenly and bone samples were obtained at necropsy from the right side of bodies within twenty-four hours after death. A tool made of titanium and plastic was used to clear samples from soft tissues and blood and to cut cortical part of bone. The IAEA and NIST reference materials (H-5 animal bone and SRM1486 bone meal) were used to estimate the precision and accuracy of results. Contents of Ca, Cl, K, Mg> Mn, Na, P, and Sr in intact bone samples were determined by instrumental neutron activation analysis using short-lived radionuclides. Our means data for each element of reference materials were within the certified 95 % confidence interval, and indicate an acceptable accuracy of the obtained results. No age- and sex-related differences in the cortical femoral neck composition were detected. Mean values (M±S.E.M.) of Ca, Cl, K, Mg, Mn, Na, P, and Sr mass fractions (on dry weight basis) for female and male all

  15. Porta-enxertos utilizados na citricultura

    Directory of Open Access Journals (Sweden)

    Schäfer Gilmar

    2001-01-01

    Full Text Available A muda cítrica é o insumo mais importante na formação de um pomar. As características mais importantes da muda cítrica são a origem do enxerto e do porta-enxerto, a qualidade do sistema radicular e a sua sanidade. Os porta-enxertos são capazes de influenciar várias características horticulturais e sanitárias nas árvores e nos frutos cítricos, como: sólidos solúveis totais, tamanho da copa e do fruto, resistência a moléstias e ao frio, distribuição da raízes, etc. O principal porta-enxerto utilizado no Brasil (cerca de 80% é o limoeiro ?Cravo? (Citrus limonia Osbeck cv. Cravo. No Rio Grande do Sul, mais especificamente, destaca-se o Poncirus trifoliata (L. Raf em mais de 90% dos pomares. Isso torna a citricultura vulnerável ao surgimento de moléstias que afetem estes porta-enxertos, como ocorreu na década de 40 em todo o Brasil com a 'Tristeza' dos citros em plantas enxertadas sobre laranjeira azeda, e, mais recentemente, com o 'declínio'. Assim, o conhecimento das características dos diversos porta-enxertos e de algumas particularidades do uso destes é de grande importância para a diversificação e escolha do porta-enxerto a ser utilizado pelo citricultor.

  16. Videogames e o aprender na complexidade

    Directory of Open Access Journals (Sweden)

    Paula Cristina Turcatto

    2016-06-01

    Full Text Available Ao conceber-se esta pesquisa, levou-se em consideração que cada ser humano aprende do seu modo pessoal e único, portanto, a proposta é pensar os videogames na sua relação com o Paradigma da Complexidade. Esta pesquisa teve como objetivo proporcionar um ambiente de encontro com diversos jogos de videogame, buscando instaurar a experimentação do novo, a abertura para o conhecer, ao habitar espaços inventivos, que valorizam a plasticidade e flexibilidade. Trata-se de uma pesquisa qualitativa, pois se propôs a trabalhar com os aspectos subjetivos como uma dimensão inseparável do conhecer. Foram 8 sujeitos de pesquisa – adolescentes – com os quais foram realizados 15 encontros, nos quais os mesmos estiveram em contato com diversos jogos de videogame. Foram utilizados diários de bordo para o registro das vivências, ancorados na metodologia cartográfica para tratamento dos registros. Os videogames propiciaram espaços para a emergência de diferentes formas de vivenciar a narrativa. Apesar de os jogos serem pré-moldados, os percursos produzidos, assim como as produções simbólicas frente ao contexto do jogo foram individuais. Jogar videogame relacionou-se ao posicionamento criador, de escrever as circunstâncias sob as quais as ações do jogo refletiram nas experiências vivenciadas pelo jogador.

  17. Insulin regulation of (Na+, K+)-ATPase

    International Nuclear Information System (INIS)

    Lytton, J.

    1985-01-01

    This thesis describes an investigation into the mechanism of insulin stimulation of (Na + ,K + )=ATPase in rat adipocytes. Two molecular forms of the catalytic subunit of the enzyme were identified and denoted α and α(+), due to their similarity to those isozymes previously described from rat brain. Insulin specifically stimulated the α(+) form of the enzyme. The two forms of the enzyme had quite different affinities for intracellular sodium ion; insulin affected only the lower affinity of α(+), shifting it toward a higher value. However, the sodium affinity of (Na + ,K + )-ATPase activity in isolated membranes was equally high for both forms of the enzyme. This suggests that the difference in sodium affinity between the two forms observed in the cell is not inherent within the structure of the sodium pump, but must depend upon a selective interaction with another molecule which has been lost upon membrane isolation. Immunoprecipitation of both the catalytic subunits either from extracts of whole cells which had been labelled with [ 32 P] orthophosphate, or from membranes which had been labelled with γ-[ 32 P]ATP demonstrated that less than 1 in 100 molecules had a covalently bound phosphate insulin had no influence on this value. The amino terminal sequences of the first 4 amino acids of the catalytic subunits of both α (isolated from rat kidney) and α(+) (from rat brainstem axolemma) were determined. The result shows two highly homologous but clearly different molecules. It can thus be concluded that the insulin sensitive version of the enzyme is not derived from the common α form by a post-translational modification

  18. LUZ, MELATONINA E ESTRESSE OXIDATIVO NA PISCICULTURA

    Directory of Open Access Journals (Sweden)

    Claudio Alberto Gellis de Mattos Dias

    2013-12-01

    Full Text Available Em peixes, como nos mamíferos, partes do sistema nervoso estão envolvidas em mecanismos para regulação dos sistemas corporais em sintonia com o meio. O fotoperíodo é traduzido em informações fisiológicas a partir da secreção de melatonina.Parece não haver barreiras morfofisiológicas para esta indolamina, isto é, a melatonina perfunde-se rapidamente em cada célula do organismo e em alguns casos interage com receptores e membrana situados na superfície celular, e parece estar ligada à ingestão de alimentos, crescimento e atividade locomotora de peixes. São moléculas importantes metabolizando espécies reativas de oxigênio a produtos inativos e, portanto, reduzindo o dano oxidativo.Este trabalho tem por objetivo fazer um breve levantamento em artigos recentes sobre luminosidade, melatonina e o estresse oxidativo em peixes, e correlaciona-los com piscicultura. Concluímos que a luminosidade parece estar ligada a produção de melatonina, e esta molécula antioxidante, que favorece a redução do estresse oxidativo, parecem melhorar o desempenho na produção de peixes em criadouros. Palavras-chave: Melatonina, estresse oxidativo, piscicultura. DOI: http://dx.doi.org/10.18561/2179-5746/biotaamazonia.v3n3p169-176

  19. Vogais na amazônia paraense

    Directory of Open Access Journals (Sweden)

    Regina Cruz

    2012-01-01

    Full Text Available Este artigo trata essencialmente de uma apresentação das ações do projeto institucional Norte Vogais vinculado ao Diretório Nacional PROBRAVO. O artigo fornece uma ideia precisa de como a equipe da UFPA vinculada ao PROBRAVO está conduzindo suas investigações sobre a variedade do português falada no Pará. O projeto Norte Vogais conta com amostras de fala de trezentos e dezoito informantes nativos do Pará no seu banco de dados. As descrições sociolinguísticas empreendidas pela equipe da UFPA priorizaram a investigação de três aspectos fonéticos em particular: a a variação das vogais médias pretônicas; b a variação das vogais médias postônicas mediais e; c a nasalidade alofônica. Os resultados obtidos reforçam a hipótese de Silva Neto (1957 de que o Pará compreenderia uma ilha dialetal na classificação de Antenor Nascente entre os dialetos do Norte do Brasil. Com o objetivo de refinar as descrições sociolingüísticas, duas novas ações se impuseram: a o mapeamento da situação sociolinguística das áreas de contato interdialetal no Pará e; b a análise acústica do sistema vocálico do português falado na Amazônia Paraense.

  20. VOGAIS NA AMAZÔNIA PARAENSE

    Directory of Open Access Journals (Sweden)

    Regina Fernandes Cruz

    2012-12-01

    Full Text Available Este artigo trata essencialmente de uma apresentação das ações do projeto institucional Norte Vogais vinculado ao Diretório Nacional PROBRAVO. O artigo fornece uma ideia precisa de como a equipe da UFPA vinculada ao PROBRAVO está conduzindo suas investigações sobre a variedade do português falada no Pará. O projeto Norte Vogais conta com amostras de fala de trezentos e dezoito informantes nativos do Pará no seu banco de dados. As descrições sociolinguísticas empreendidas pela equipe da UFPA priorizaram a investigação de três aspectos fonéticos em particular: a a variação das vogais médias pretônicas; b a variação das vogais médias postônicas mediais e; c a nasalidade alofônica. Os resultados obtidos reforçam a hipótese de Silva Neto (1957 de que o Pará compreenderia uma ilha dialetal na classificação de Antenor Nascente entre os dialetos do Norte do Brasil. Com o objetivo de refinar as descrições sociolingüísticas, duas novas ações se impuseram: a o mapeamento da situação sociolinguística das áreas de contato interdialetal no Pará e; b a análise acústica do sistema vocálico do português falado na Amazônia Paraense.

  1. Mercury's Na Exosphere from MESSENGER Data

    Science.gov (United States)

    Killen, Rosemary M.; Burger, M. H.; Cassidy, T. A.; Sarantos, M.; Vervack, R. J.; McClintock, W. El; Merkel, A. W.; Sprague, A. L.; Solomon, S. C.

    2012-01-01

    MESSENGER entered orbit about Mercury on March 18, 2011. Since then, the Ultraviolet and Visible Spectrometer (UWS) channel of MESSENGER's Mercury Atmospheric and Surface Composition Spectrometer (MASCS) has been observing Mercury's exosphere nearly continuously. Daily measurements of Na brightness were fitted with non-uniform exospheric models. With Monte Carlo sampling we traced the trajectories of a representative number of test particles, generally one million per run per source process, until photoionization, escape from the gravitational well, or permanent sticking at the surface removed the atom from the simulation. Atoms were assumed to partially thermally accommodate on each encounter with the surface with accommodation coefficient 0.25. Runs for different assumed source processes are run separately, scaled and co-added. Once these model results were saved onto a 3D grid, we ran lines of sight from the MESSENGER spacecraft :0 infinity using the SPICE kernels and we computed brightness integrals. Note that only particles that contribute to the measurement can be constrained with our method. Atoms and molecules produced on the nightside must escape the shadow in order to scatter light if the excitation process is resonant-light scattering, as assumed here. The aggregate distribution of Na atoms fits a 1200 K gas, with a PSD distribution, along with a hotter component. Our models constrain the hot component, assumed to be impact vaporization, to be emitted with a 2500 K Maxwellian. Most orbits show a dawnside enhancement in the hot component broadly spread over the leading hemisphere. However, on some dates there is no dawn/dusk asymmetry. The portion of the hot/cold source appears to be highly variable.

  2. RNA adducts with Na 2SeO 4 and Na 2SeO 3 - Stability and structural features

    Science.gov (United States)

    Nafisi, Shohreh; Manouchehri, Firouzeh; Montazeri, Maryam

    2011-12-01

    Selenium compounds are widely available in dietary supplements and have been extensively studied for their antioxidant and anticancer properties. Low blood Se levels were found to be associated with an increased incidence and mortality from various types of cancers. Although many in vivo and clinical trials have been conducted using these compounds, their biochemical and chemical mechanisms of efficacy are the focus of much current research. This study was designed to examine the interaction of Na 2SeO 4 and Na 2SeO 3 with RNA in aqueous solution at physiological conditions, using a constant RNA concentration (6.25 mM) and various sodium selenate and sodium selenite/polynucleotide (phosphate) ratios of 1/80, 1/40, 1/20, 1/10, 1/5, 1/2 and 1/1. Fourier transform infrared, UV-Visible spectroscopic methods were used to determine the drug binding modes, the binding constants, and the stability of Na 2SeO 4 and Na 2SeO 3-RNA complexes in aqueous solution. Spectroscopic evidence showed that Na 2SeO 4 and Na 2SeO 3 bind to the major and minor grooves of RNA ( via G, A and U bases) with some degree of the Se-phosphate (PO 2) interaction for both compounds with overall binding constants of K(Na 2SeO 4-RNA) = 8.34 × 10 3 and K(Na 2SeO 3-RNA) = 4.57 × 10 3 M -1. The order of selenium salts-biopolymer stability was Na 2SeO 4-RNA > Na 2SeO 3-RNA. RNA aggregations occurred at higher selenium concentrations. No biopolymer conformational changes were observed upon Na 2SeO 4 and Na 2SeO 3 interactions, while RNA remains in the A-family structure.

  3. Growth mechanism of NaClO3 and NaBrO3 crystals from aqueous ...

    Indian Academy of Sciences (India)

    Unknown

    tamura (1978) developed a sophisticated apparatus for in situ observation and studied the growth of NaClO3 crys- tals. Tsukamoto and Sunagawa (1990) made a systematic study of the growth of KCl in the presence of Pb ions. Though we have reported studies on growth of NaClO3 and NaBrO3 crystals, they were largely ...

  4. Anisotropy and polarization in charge changing collisions of C4+ with Na(3s) and laser aligned Na(3p)

    NARCIS (Netherlands)

    Hoekstra, R; Morgenstern, R; Olson, RE

    1996-01-01

    Absolute cross sections for C3+(6-->5) emission at 465.7 nm after collisions of C4+ ions with ground state Na(3s) and laser excited aligned Na(Sp) atoms are measured over the collision energy range of 3-7 keV amu(-1). For Na(3s) polarizations are observed by measuring the linear polarization of the

  5. Crystal structure of polyphosphates NaCd(PO3)3 and NaMn(PO3)3

    International Nuclear Information System (INIS)

    Murashova, E.V.; Chudinova, N.N.

    1997-01-01

    Crystal structure of NaCd(PO 3 ) 3 (1) and NaMn(PO 3 ) 3 (2) isostructural polyphosphates was determined for twin samples. Rhombic lattice parameters of (1): a = 14.678, b = 14.669, c = 14.705 A, sp. gr. P2 1 2 1 2 1 , Z = 16. The structure of compounds is of frame type. Polyphosphate chain with repetition period of 24 PO 4 tetrahedrons contacts with NaO 6 and M 2 O 6 octahedrons by means of common oxygen vertices. Similarities and differences in structure of mentioned polyphosphates and earlier analyzed NaMg(PO 3 ) 3 polyphosphate are noted [ru

  6. Dicty_cDB: Contig-U05201-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available NA c... 44 0.91 2 ( FC829938 ) CBHI3150.rev CBHI Metridium senile tentacle Metri....1.7 6 ( AC130106 ) Rattus norvegicus clone CH230-17N23, WORKING DRAF... 44 1.7 3 ( FC829939 ) CBHI3150.fwd CBHI Metridium senile tent...acle Metri... 32 1.7 3 ( CX708675 ) gmrtDrNS01_38-C_M13R_H07_049.s1 Water stressed

  7. 43. Calmodulin regulating calcium sensitivity of Na channels

    Directory of Open Access Journals (Sweden)

    R. Vegiraju

    2016-07-01

    Full Text Available By extrapolating information from existing research and observing previous assumptions regarding the structure of the Na Channel, this experiment was conducted under the hypothesis that the Na Channel is in part regulated by the calmodulin protein, as a result proving calcium sensitivity of the Na Channel. Furthermore, we assume that there is a one to one stoichiometry between the Na Channel and the Calmodulin. There has been extensive research into the functionality and structure of sodium ion channels (Na channels, as several diseases are associated with the lack of regulation of sodium ions, that is caused by the disfunction of these Na channels. However, one highly controversial matter in the field is the importance of the protein calmodulin (CaM and calcium in Na channel function. Calmodulin is a protein that is well known for its role as a calcium binding messenger protein, and that association is believed to play an indirect role in regulating the Na channel through the Na channel’s supposed calcium sensitivity. While there are proponents for both sides, there has been relatively little research that provides strong evidence for either case. In this experiment, the effect of calmodulin on NaV 1.5 is tested by preparing a set of cardiac cells (of the human specie with the NaV 1.5 C-Termini and CaM protein, which were then to be placed in solutions with varying concentrations of calcium. We took special care to test multiple concentrations of calcium, as previous studies have tested very low concentrations, with Manu Ben-Johny’s team from the John Hopkins laboratory in particular testing up to a meager 50 micromolar, despite producing a well-respected paper (By comparison, the average Na channel can naturally sustain a concentration of almost 1-2 millimolar and on some occasions, reaching even higher concentrations. After using light scattering and observing the signals given off by the calcium interacting with these Nav1.5/Ca

  8. Estratégias na Terapêutica Transfusional na Malária e Drepanocitose

    OpenAIRE

    Barra, A

    2017-01-01

    Um mesmo mundo, diferentes realidades Apesar dos casos de malária, no mundo, terem diminuído de aproximadamente 40 milhões entre 2000 e 2015, neste último ano o número estimado de mortes por malária ainda rondou os 438.000, sendo 88% destas na região africana.(1) Em 2011 os casos de morte por malária aconteceram maioritariamente em crianças com menos de 5 anos de idade na África subsaariana.(2) As grávidas, são um grupo, com um risco aumentado de morbilidade e mortalidade, que se es...

  9. Sliding wear behaviour of steel carburized using Na2CO3-NaCl

    Directory of Open Access Journals (Sweden)

    Liew Willey Y. H.

    2017-01-01

    Full Text Available Experiments have been carried out to investigate the effect of carburization process on the sliding wear resistance of mild steel. The carburization process was conducted in carbonate salts mixtures of Na2CO3-NaCl. Carburization followed by water quenching resulted in the formation of martensite with a hardness of 900 HV in the subsurface, up to the depth of 400 μm. This hardness value was substantially higher than the non-carburized steel which had a hardness of 520 HV. In the initial stage of sliding in air, abrasive wear and cluster of fine cavities due to adhesion were formed. This was followed by the formation of large-scale fracture at the cavities. The high hardness of the carburized steel reduced the severity of adhesive wear and thus the tendency of the worn surface to fracture.

  10. Impact of childhood stress on psychopathology Impacto de estresse na infância na psicopatologia

    Directory of Open Access Journals (Sweden)

    Elisa Brietzke

    2012-12-01

    Full Text Available OBJECTIVE: Advances in our knowledge of mental disorder (MD genetics have contributed to a better understanding of their pathophysiology. Nonetheless, several questions and doubts persist. Recent studies have focused on environmental influences in the development of MDs, and the advent of neuroscientific methodologies has provided new perspectives. Early life events, such as childhood stress, may affect neurodevelopment through mechanisms such as gene-environment interactions and epigenetic regulation, thus leading to diseases in adulthood. The aim of this paper is to review the evidence regarding the role of the environment, particularly childhood stress, in the pathophysiology of MD. METHODOLOGY: We reviewed articles that evaluated environmental influences, with a particular focus on childhood trauma, brain morphology, cognitive functions, and the development of psychopathology and MD. RESULTS AND CONCLUSION: MRI studies have shown that exposure to trauma at an early age can result in several neurostructural changes, such as the reduction of the hippocampus and corpus callosum. Cognitive performance and functioning are also altered in this population. Finally, childhood stress is related to an increased risk of developing MD such as depression, bipolar disorder, schizophrenia and substance abuse. We conclude that there is robust evidence of the role of the environment, specifically adverse childhood experiences, in various aspects of MD.OBJETIVO: Avanços no conhecimento da genética dos transtornos mentais (TM contribuíram para um melhor entendimento de suas bases fisiopatológicas. No entanto, dúvidas e questões ainda persistem. Estudos recentes têm se concentrado nas influências do ambiente no desenvolvimento de TM, e o advento de metodologias neurocientíficas oferece novas perspectivas. Eventos precoces de vida, como estresse na infância, podem ser capazes de alterar o neurodesenvolvimento através de mecanismos como intera

  11. Measurement of direct CP-violation with the experiments NA31 and NA48 at CERN

    International Nuclear Information System (INIS)

    Renk, B.

    1992-01-01

    The NA31 experiment has measured the CP violation parameter var-epsilon '/var-epsilon. The result of data collected in 1988 is Re(var-epsilon '/var-epsilon)=(1.7±1.0)x10 -3 . A preliminary result of data collected in 1989 is Re(var-epsilon '/var-epsilon)=(2.1±0.9)x10 -3 . Combining these two results with the original result from the 1986 data set we obtain Re(var-epsilon '/var-epsilon)=(2.3±0.7)x10 -3 , which is a more than three standard deviation evidence for direct CP violation. A new experiment NA48 is under construction which aims for a significant reduction of the statistical and the systematical errors in order to reach a combined error not exceeding 2x10 -4

  12. O Platonismo de Russell na metafísica e na matemática

    Directory of Open Access Journals (Sweden)

    Guido Imaguire

    2005-06-01

    Full Text Available Neste artigo, analiso o surgimento e a superação do Platonismo em B. Russell, tanto na sua filosofia da matemática como na sua metafísica. Começo por explicitar os argumentos que levaram Russell a aderir ao chamado "Platonismo Proposicional" - posição que será tecnicamente relevante na definição de números. Na seção seguinte, discutirei até que ponto a teoria das descrições definidas determina, necessariamente, uma adesão ao nominalismo, e as dificuldades que surgem para o logicismo conseqüentes do abandono do platonismo. Finalmente, mostrarei como a posição madura de Russell caracteriza-se mais como um reducionismo do que propriamente como um nominalismo, e como este é fundado no princípio do mínimo vocabulário.In this paper, I analyze the emergence and the overcoming of Platonism both in Russell's philosophy of mathematics and his metaphysics. I begin by examining the arguments which led Russell to endorse a position that I term "Propositional Platonism" - this position proves to be relevant for Russell's definition of numbers. In the following section, I address the question of the extent to which Russell's theory of descriptions implies the acceptance of nominalism. Moreover, I examine the difficulties which arise for logicism, if it no longer goes hand in hand with platonism. Finally, I argue argue that Russell's mature position is to be characterized as a form of reductionism rather than as a variant of nominalism

  13. A PALAVRA DE DEUS NA VIDA E NA MISSÃO DA IGREJA

    Directory of Open Access Journals (Sweden)

    Dom Eugênio Rixen

    2009-01-01

    Full Text Available Tive a oportunidade de participar do XII Sínodo dos Bispos em Roma, de 5 a 26 de outubro de 2008. Os sínodos foram realizados após o Concílio Vaticano II, para ajudar o Santo Padre na sua missão pastoral, e como testemunho fraterno entre os bispos do mundo inteiro em comunhão com o papa.

  14. CULTURA DOS ALUNOS NA PRÉ-ESCOLA E NA "ESCOLA PRIMÁRIA"

    Directory of Open Access Journals (Sweden)

    Ruth Bernardes de Sant'Ana

    2015-06-01

    Full Text Available O objetivo deste artigo é discutir a cultura dos alunos, com ênfase na pré-escola e nos primeiros anos do Ensino Fundamental ("escola primária". As escassas teorizações sobre o assunto mostram limitações, na medida em que recaem sobre os alunos das últimas séries do Ensino Fundamental ou sobre o Ensino Médio, ou seja, sobre os adolescentes como grupo etário. A partir de dados de pesquisa de campo e de estudos teóricos, identificamos que a cultura dos alunos é uma cultura intraescolar, que se concretiza na intersecção entre a cultura infantil e a cultura escolar, com diferentes níveis de proximidade e distanciamento entre elas. Ela envolve comportamentos estratégicos infantis de oposição e de resistência às tarefas e ao poder docente. Quando a escola recusa o acolhimento da cultura infantil, esta se produz nos interstícios das atividades escolares, por vezes de maneira conflituosa.

  15. Structural basis for Na(+) transport mechanism by a light-driven Na(+) pump.

    Science.gov (United States)

    Kato, Hideaki E; Inoue, Keiichi; Abe-Yoshizumi, Rei; Kato, Yoshitaka; Ono, Hikaru; Konno, Masae; Hososhima, Shoko; Ishizuka, Toru; Hoque, Mohammad Razuanul; Kunitomo, Hirofumi; Ito, Jumpei; Yoshizawa, Susumu; Yamashita, Keitaro; Takemoto, Mizuki; Nishizawa, Tomohiro; Taniguchi, Reiya; Kogure, Kazuhiro; Maturana, Andrés D; Iino, Yuichi; Yawo, Hiromu; Ishitani, Ryuichiro; Kandori, Hideki; Nureki, Osamu

    2015-05-07

    Krokinobacter eikastus rhodopsin 2 (KR2) is the first light-driven Na(+) pump discovered, and is viewed as a potential next-generation optogenetics tool. Since the positively charged Schiff base proton, located within the ion-conducting pathway of all light-driven ion pumps, was thought to prohibit the transport of a non-proton cation, the discovery of KR2 raised the question of how it achieves Na(+) transport. Here we present crystal structures of KR2 under neutral and acidic conditions, which represent the resting and M-like intermediate states, respectively. Structural and spectroscopic analyses revealed the gating mechanism, whereby the flipping of Asp116 sequesters the Schiff base proton from the conducting pathway to facilitate Na(+) transport. Together with the structure-based engineering of the first light-driven K(+) pumps, electrophysiological assays in mammalian neurons and behavioural assays in a nematode, our studies reveal the molecular basis for light-driven non-proton cation pumps and thus provide a framework that may advance the development of next-generation optogenetics.

  16. Paisagismo e modernidade na europa na década de 1920

    Directory of Open Access Journals (Sweden)

    Euler Sandeville Júnior

    2007-12-01

    Full Text Available Experiências formais realizadas a partir do final da Primeira Guerra deram novo impulso à reformulação das concepções então correntes para os jardins. Notamos algumas tendências contrastantes que coexistiam nessa época: uma, então dominante, representada por um ambiente profissional respondendo a uma demanda particular e do Estado, de caráter conservador e nacionalista, outras, de renovação, representadas por paisagistas e por arquitetos de alguma forma vinculados às vanguardas. O objetivo deste trabalho é destacar duas tendências modernizantes atuando na produção paisagística na Europa dos anos de 1920. Uma delas, desenvolvida por paisagistas e arquitetos, mostra forte influência do cubismo e do expressionismo, convergindo para o art déco, dotada de forte conotação decorativa. Gabriel Guevrekian e Robert Mallet-Stevens, são alguns dos representantes dessa tendência. Outra tendência modernizante deve-se à atuação de representantes do nascente movimento moderno em arquitetura, tanto em sua abordagem dos jardins como também nos conceitos que empregaram na criação de espaços externos. Entre a ampla gama de experiências nesse sentido, vêem-se as posturas bem diversas apresentadas por arquitetos como Le Corbusier e Erik Gunnar Asplund.

  17. SUPERANDO CONFLITOS NA CONSTRUÇÃO DE UMA PESQUISA COLABORATIVA NA ESCOLA

    Directory of Open Access Journals (Sweden)

    Patrícia de Oliveira Rosa-Silva

    Full Text Available Resumo: Este estudo enfoca a construção de uma parceria na formação continuada de uma professora de Ciências durante o desenvolvimento de uma pesquisa colaborativa. Analisa episódios de resistências e tensões, assim como ações e reações tanto da pesquisadora como da professora que foram capazes de ajustar e superar tais conflitos para consolidar a pesquisa. O processo de formação continuada envolveu uma estratégia de intervenção reflexiva, denominada autoscopia, simulando uma "sala de espelhos" (SCHÖN, 2000, que levou a professora a refletir sobre a sua prática educativa. Os resultados demonstram que a pesquisa colaborativa, centrada no diálogo e no companheirismo, foi mediadora na solução dos conflitos vivenciados no processo e favoreceu a tomada de decisões na consolidação de estratégias de formação continuada voltadas à professora.

  18. MCHANGO WA MWALIMU J.K. NYERERE KATIKA TAFSIRI NA ...

    African Journals Online (AJOL)

    Kwa kuzingatia tafsiri mbili za J.K. Nyerere, Julius Kaizer (1963) na Mabepari wa Venus (1969), makala inaeleza: (i) kwa nini Mwalimu Nyerere alitafsiri maandishi ya Shakespeare, (ii) ufanisi wa tafsiri zake, na (iii) mchango wa tafsiri hizo. Makala inaonyesha kuwa tafsiri hizo zinazingatia mbinu za kisemantiki zaidi kuliko ...

  19. Kuingiliana kwa Lugha ya Kiswahili na Kiingereza: Uswahilishaji wa ...

    African Journals Online (AJOL)

    Kuingiliana kwa lugha ni taaluma katika uwanja wa isimu inayohusu lugha zinazoingiliana na kuathiriana. Kuingiliana kwa lugha sio jambo jipya katika dunia. Watu ambao ndio watumiaji wa lugha wamesababisha lugha kuiingiliana waliposafiri au kuhama sehemu moja hadi nyingine kutokana na sababu za kiuchumi, ...

  20. Ufundishaji wa Kusoma na Kuandika Kiswahili: Uzoefu wa Idara ya ...

    African Journals Online (AJOL)

    Makala haya yanahusu shughuli za kufundisha Kiswahili kama lugha ya kigeni katika Chuo Kikuu cha Sebha nchini Libya. Kwanza inaeleza historia ya Kiswahili – yaani kilianza lini kufundishwa kwa madhumuni gani na nani walikuwa wanzilishi. Halikadhalika makala ya naeleza utaratibu uliowekwa na idara ili kuweza ...

  1. Risbjerg: SF vandt valgkampen, NA og R tabte

    DEFF Research Database (Denmark)

    Thomsen, Søren Risbjerg

    2007-01-01

    ANALYSE: Endnu engang flyttede en valgkamp for alvor stemmer. SF gik undervejs 27 pct. frem, mens NA gik 34 pct. tilbage og R 26 pct. Udgivelsesdato: 25. november......ANALYSE: Endnu engang flyttede en valgkamp for alvor stemmer. SF gik undervejs 27 pct. frem, mens NA gik 34 pct. tilbage og R 26 pct. Udgivelsesdato: 25. november...

  2. Transmission channels through Na and Al atom wire

    DEFF Research Database (Denmark)

    Kobayashi, N.; Brandbyge, Mads; Tsukada, M.

    1999-01-01

    First-principles calculations of the transmission channels of single-atom-width Na and Al atom wires bridged between metallic jellium electrodes are presented. For the Na wire, a single channel contributes to the conduction with an almost full quantization value, 2e(2)/h. The conductance...

  3. Juhudi za Vyombo vya Habari katika Kukuza na Kueneza Kiswahili ...

    African Journals Online (AJOL)

    Vyombo vya habari ni asasi muhimu sana katika kukuza na kueneza lugha yoyote ile, hasa katika enzi hii ya utandawazi. Vyombo hivyo ni kama vile idhaa za redio, televisheni na magazeti. Katika nchi ya Kenya kuna vyombo vya habari vinavyotoa huduma anuwai kwa ajili ya kutosheleza mahitaji ya wateja wao. Katika ...

  4. Substrate Specificity of Na+,Cl-(HCO3-)-ATPase.

    Science.gov (United States)

    Yurkiv, V A; Melikhov, V I; Shubin, V S

    2016-09-01

    We studied substrate specificity of Na + ,Cl - (HCO 3 - )-ATPase. In most cases, replacement of ATP for other phosphate-containing substances resulted in not only pronounced suppression of phosphohydrolase reactions, but also dramatic changes of their responsiveness to the stimulating effect of monovalent ions. The data showed that Na + ,Cl - (HCO 3 - )-ATPase is a highly specific enzyme for ATP.

  5. utandawazi na dhima ya kiswahili kama lugha ya afrika mashariki

    African Journals Online (AJOL)

    Kutokana na kusambaa huko katika matumizi inawezekana neno “utandawazi” likawa na maana zinazotofautiana kidogo kutoka uwanja hadi uwanja. Katika kutazama fasili mbalimbali za neno hilo, makala hii inabainisha kuwa tunaweza kujua ipi ni dhana ya msingi ambayo huzingatiwa hata kama pengine maelezo ya ...

  6. Effect NaOH Concentration on Bagasse Ash Based Geopolymerization

    Directory of Open Access Journals (Sweden)

    Saloma

    2016-01-01

    Full Text Available Geopolymer is a natural adhesive material which can be developed as a substitute for cement. The natural ingredients which want to use should contain silica and alumina. This paper uses bagasse ash as a basic material of mortar geopolymer. As an adhesive, the bagasse ash should be mixed with water and another activator alkali such as sodium hydroxide (NaOH and sodium silicate (Na2SiO3. The NaOHs molarity variation are 8, 10, 12, 14 and 16 M with Na2SiO3/NaOH = 1,0 sand/bagasse ash = 2,75 and activator/bagasse ash = 0,42. This research use 50 × 50 × 50 mm cube sized specimen and conduct a compressive strength test with 3, 7, 14, 21 and 28 days. The fresh mortar test result showed that the use of NaOHs molarity variation influences the slump value and time setting. The bigger NaOH molarity variation that been used, the smaller slump value. But, the time setting is increased. While the result for density and compressive strength shown that the bigger NaOH molarity variation, the bigger density and the compressive strength. Maximum compressive strength resulted from the mixture of mortar geopolymer with 16 M concentration.

  7. Mbinu na Mikakati ya Kutumia Fasihi ya Watoto kama Bibliotherapia ...

    African Journals Online (AJOL)

    Mbinu na Mikakati ya Kutumia Fasihi ya Watoto kama Bibliotherapia. Pamela M.Y. Ngugi. Abstract. Katika ulimwengu wa sasa, sanaa ya uchoraji, dansi, muziki na hata fasihi imechukuliwa kama aina moja ya tiba kwa wagonjwa wanaougua magonjwa mbalimbali. Wataalamu wa tiba-therapia wameanza kutumia fasihi ...

  8. Transepithelial Na+ transport and the intracellular fluids: a computer study.

    Science.gov (United States)

    Civan, M M; Bookman, R J

    1982-01-01

    Computer simulations of tight epithelia under three experimental conditions have been carried out, using the rheogenic nonlinear model of Lew, Ferreira and Moura (Proc. Roy. Soc. London. B 206:53-83, 1979) based largely on the formulation of Koefoed-Johnsen and Ussing (Acta Physiol. Scand. 42: 298-308. 1958). First, analysis of the transition between the short-circuited and open-circuited states has indicated that (i) apical Cl- permeability is a critical parameter requiring experimental definition in order to analyze cell volume regulation, and (ii) contrary to certain experimental reports, intracellular Na+ concentration (ccNa) is expected to be a strong function of transepithelial clamping voltage. Second, analysis of the effects of lowering serosal K+ concentration (csK) indicates that the basic model cannot simulate several well-documented observations; these defects can be overcome, at least qualitatively, by modifying the model to take account of the negative feedback interaction likely to exist between the apical Na+ permeability and ccNa. Third, analysis of the strongly supports the concept that osmotically induced permeability changes in the apical intercellular junctions play a physiological role in conserving the body's stores of NaCl. The analyses also demonstrate that the importance of Na+ entry across the basolateral membrane is strongly dependent upon transepithelial potential, cmNa and csK; under certain conditions, net Na+ entry could be appreciably greater across the basolateral than across the apical membrane.

  9. Isolation and preliminary function analysis of a Na + /H + antiporter ...

    African Journals Online (AJOL)

    A full-length cDNA Na+/H+ antiporter gene (MzNHX1) was isolated from Malus zumi according to the homologous Na+/H+ antiporter gene region in plants. Sequence analysis indicated that the cDNA was 2062 bp in length, including an open reading frame (ORF) of 1629 bp, which encoded a predicted polypeptide of 542 ...

  10. O surto rearmamentista na América do Sul

    OpenAIRE

    Eloi Martins Senhoras

    2010-01-01

    O presente artigo objetiva analisar o processo
    de crescente rearmamento presente na América do Sul
    tomando como referência uma visão internacionalista
    fenômeno que se desdobra na região.

  11. Rotational dynamics of propylene inside Na-Y zeolite cages

    Indian Academy of Sciences (India)

    molecules etc. Several such dependences have been under investigation [2]. We have in particular been investigating the diffusivities of hydrocarbons in Na-Y ze- olitic cages. In this context we had earlier reported the translational diffusivities of propane, acetylene and 1,3-butadiene in Na-Y zeolite [3–5]. The translational.

  12. Uhusiano wa Kimatengo na Kindendeule: Ushahidi wa Kiisimu ...

    African Journals Online (AJOL)

    Licha ya utengano huo, kuna madai ya muda mrefu kwamba Kimatengo na Kindendeule ni lugha zinazofanana. Makala haya yalitumia data ya uwandani ili kupata ushahidi wa kiisimu unaoweza kueleza kiwango cha kufanana au kutofautiana baina ya lugha hizo mbili. Mbinu za hojaji na majadiliano zilitumika kupata ...

  13. Numerična in eksperimentalna analiza delovanja Teslinega ventilatorja

    OpenAIRE

    Lukačič, Rajko

    2017-01-01

    Nikola Tesla je patentiral ventilator, ki deluje na principu trenja. V diplomskem delu je opisano delovanje Teslinega ventilatorja in teoretično ozadje njegovega delovanja z namenom zmanjševanja hrupa. V sami raziskavi smo s programom Ansys izdelali numerični model, ki temelji na turbulentnem modelu k-

  14. Sepsis does not alter red blood cell glucose metabolism or Na+ concentration: A 2H-, 23Na-NMR study

    International Nuclear Information System (INIS)

    Hotchkiss, R.S.; Song, S.K.; Ling, C.S.; Ackerman, J.J.; Karl, I.E.

    1990-01-01

    The effects of sepsis on intracellular Na+ concentration ([Na+]i) and glucose metabolism were examined in rat red blood cells (RBCs) by using 23Na- and 2H-nuclear magnetic resonance (NMR) spectroscopy. Sepsis was induced in 15 halothane-anesthetized female Sprague-Dawley rats by using the cecal ligation and perforation technique; 14 control rats underwent cecal manipulation without ligation. The animals were fasted for 36 h, but allowed free access to water. At 36 h postsurgery, RBCs were examined by 23Na-NMR by using dysprosium tripolyphosphate as a chemical shift reagent. Human RBCs from 17 critically ill nonseptic patients and from 7 patients who were diagnosed as septic were also examined for [Na+]i. Five rat RBC specimens had [Na+]i determined by both 23Na-NMR and inductively coupled plasma-atomic emission spectroscopy (ICP-AES). For glucose metabolism studies, RBCs from septic and control rats were suspended in modified Krebs-Henseleit buffer containing [6,6-2H2]glucose and examined by 2H-NMR. No significant differences in [Na+]i or glucose utilization were found in RBCs from control or septic rats. There were no differences in [Na+]i in the two groups of patients. The [Na+]i determined by NMR spectroscopy agreed closely with measurements using ICP-AES and establish that 100% of the [Na+]i of the RBC is visible by NMR. Glucose measurements determined by 2H-NMR correlated closely (correlation coefficient = 0.93) with enzymatic analysis. These studies showed no evidence that sepsis disturbed RBC membrane function or metabolism

  15. Avaliação das alterações fundoscópicas na miopia degenerativa Fundus changes evaluation in degenerative myopia

    Directory of Open Access Journals (Sweden)

    Oswaldo Ferreira Moura Brasil

    2006-04-01

    Full Text Available OBJETIVO: Avaliar a presença de alterações fundoscópicas em pacientes portadores de miopia degenerativa. MÉTODOS: Quarenta pacientes com erro refrativo de pelo menos -6,00 dioptrias foram selecionados para exame oftalmológico, complementado por retinografia do pólo posterior e ecobiometria. RESULTADOS: Foram estudados 57 olhos de 37 pacientes com erro refrativo de -6,25 a -28,50 dioptrias, com média de -14,05, e comprimento axial de 26,06 a 32,86 mm, com média de 28,01. Encontramos crescente temporal em 36,5% e circunferencial em 21% dos olhos. Vasos da coróide foram visualizados em 35% dos olhos. As alterações do pólo posterior foram as seguintes: estafiloma posterior em 10,5%, mancha de Fuchs em 3,5% e "lacquer cracks" em 1,5%. O exame da periferia retiniana evidenciou atrofia corio-retiniana tipo pavimentosa em 17,5%, branco sem pressão em 10,5%, degeneração "lattice" em 5%, ruptura retiniana em 3,5% e retinosquise em 1,5% dos olhos examinados. CONCLUSÕES: Alterações fundoscópicas que levam à baixa visual são freqüentes em pacientes com miopia degenerativa. O exame da periferia retiniana é muito importante nestes pacientes devido ao risco aumentado de descolamento de retina.PURPOSE: To evaluate the presence of fundus changes in degenerative myopia. METHODS: Forty patients with refractive error of at least -6.00 diopters were selected for ophthalmologic examination followed by posterior pole photograph and echobiometry. RESULTS: We studied 57 eyes of 37 patients with refractive error ranging from -6.25 to -28.50 diopters, with mean -14.05, and axial length ranging from 26.06 to 32.86 mm, with mean 28.01. We found a temporal crescent in 36.5% and a peripapillary one in 20% of the eyes. Choroidal vessels were seen in 35% of the eyes. Posterior pole changes were as follow: posterior staphyloma in 10.5%, Fuchs' spots in 3.5% and lacquer cracks in 1.5%. Peripheral retinal examination revealed paving stone chorioretinal

  16. Effect of aspherical and yellow tinted intraocular lens on blue-on-yellow perimetry Efeito das lentes intraoculares asféricas e com pigmentação amarela na campimetria azul-amarelo

    Directory of Open Access Journals (Sweden)

    Rodrigo França de Espíndola

    2012-10-01

    Full Text Available PURPOSE: To investigate the possible effect of aspherical or yellow tinted intraocular lens (IOL on contrast sensitivity and blue-on-yellow perimetry. METHODS: This prospective randomized bilateral double-masked clinical study included 52 patients with visually significant bilateral cataracts divided in two groups; 25 patients (50 eyes received aspherical intraocular lens in one eye and spherical intraocular lens in the fellow eye; and 27 patients (54 eyes received ultraviolet and blue light filter (yellow tinted IOL implantation in one eye and acrylic ultraviolet filter IOL in the fellow eye. The primary outcome measures were contrast sensitivity and blue-on-yellow perimetry values (mean deviation [MD] and pattern standard deviation [PSD] investigated two years after surgery. The results were compared intra-individually. RESULTS: There was a statistically significant between-group (aspherical and spherical intraocular lens difference in contrast sensitivity under photopic conditions at 12 cycles per degree and under mesopic conditions at all spatial frequencies. There were no between-group significant differences (yellow tinted and clear intraocular lens under photopic or mesopic conditions. There was no statistically significant difference between all intraocular lens in MD or PSD. CONCLUSION: Contrast sensitivity was better under mesopic conditions with aspherical intraocular lens. Blue-on-yellow perimetry did not appear to be affected by aspherical or yellow tinted intraocular lens. Further studies with a larger sample should be carried out to confirm or not that hypotheses.OBJETIVO: Investigar a possibilidade de efeitos na sensibilidade ao contraste e nos resultados da campimetria azul-amarelo com implante de uma lente intraocular (LIO asférica ou de pigmentação amarela. MÉTODOS: Trata-se de um estudo prospectivo, randomizado, duplo-mascarado, envolvendo 52 pacientes portadores de catarata senil bilateral, divididos em dois grupos; 25

  17. Experiments on cold trap regeneration by NaH decomposition

    International Nuclear Information System (INIS)

    McPheeters, C.C.; Skladzien, S.B.; Raue, D.J.

    1979-10-01

    Cold trap regeneration may be very important in future LMFBRs because of the expected high hydrogen source from the steam generators. This hydrogen precipitates as NaH in the cold trap and may fill the trap within one year of operation. Several methods of cold trap regeneration were considered, but the simplest and least expensive appears to be decomposition of NaH under vacuum at elevated temperatures. Experiments were done to assess the feasibility of this method for cold trap regeneration. Small-scale simulated cold traps (SCT) were located with NaH and NaH plus Na 2 O, and were heated both under vacuum and under a sweep gas at 100 kPa. The evolved hydrogen was converted to water by a CuO bed and collected in a weighting tube

  18. Binary phosphates NaLnP2O7

    International Nuclear Information System (INIS)

    Anisimova, N.Yu.; Trunov, V.K.; Chudinova, N.N.

    1988-01-01

    The results of synthesis and identification of compounds of the NaLnP 2 O 7 (Ln=La,...Lu) composition are presented. 14 compounds of the above composition referring to two structural types are prepared and characterized. The data on NaLnP 2 O 7 synthesis in the Na 2 O-Ln:2O 3 -P 2 O 5 system are given. Binary phosphates of the NaLnP 2 O 7 -type (Ln=La,...Lu) are separated and identified in the subsolidus part of the Na 2 O-Ln 2 O 3 -P 2 O 5 system. Their crystallochemical parameters are determined and the presence of two structural types in the La-Lu series is shown. Thermal stability of binary phosphates is studied

  19. The New Readout System of the NA62 LKr Calorimeter

    CERN Document Server

    Ceccucci, A; Farthouat, P; Lamanna, G; Rouet, J; Ryjov, V; Venditti, S

    2015-01-01

    The NA62 experiment [1] at CERN SPS (Super Proton Synchrotron) accelerator aims at studying Kaon decays with high precision. The high resolution Liquid Krypton (LKr) calorimeter, built for the NA48 [2] experiment, is a crucial part of the photon-veto system; to cope with the demanding NA62 re- quirements,itsback-endelectron icshadtobecompletelyrenewed. The new readout system is based on the Calorimeter REAdout Module (CREAM) [3], a 6U VME board whose design and pro- duction was sub-contracted to CAEN [4], with CERN NA62 group continuously supervising the de velopment and production phase. The first version of the board was delivered by the manufacturer in March 2013 and, as of June 2014, the full board production is ongoing. In addition to describing the CREAM board, all aspects of the new LKr readout system, including its integration within the NA62 TDAQ scheme, will be treated.

  20. Na,K-pump modulates intercellular communication in vascular wall

    DEFF Research Database (Denmark)

    Matchkov, Vladimir; Nilsson, Holger; Aalkjær, Christian

      Ouabain, a specific inhibitor of the Na,K-pump, has previously been shown to interfere with intercellular communication. Here we test the hypothesis that the communication between vascular smooth muscle cells (SMCs) is regulated through an interaction between the Na,K-pump and the Na...... were used as a model for electrical coupling of SMCs by measuring membrane capacitance (Cm). SMCs were uncoupled (evaluated by inhibition of vasomotion and desynchronization of calcium transients in vascular wall, or by reduction to half of Cm measured in paired A7r5 cells) when the Na,K-pump...... was inhibited either by a low concentration of ouabain or by ATP depletion. Uncoupling with ouabain was associated with a localized increase of intracellular calcium in discrete sites near the plasma membrane. Reduction of Na,K-pump activity by removal of extracellular potassium also uncoupled cells, but only...