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4

The utility of screening for perinatal depression in the second trimester among Chinese: a three-wave prospective longitudinal study

Lau, Ying; Wong, Keung Fu Daniel; Chan, Sin Kin

This paper aims to study the pattern of perinatal depressive symptomatology and determine the predictive power of second trimester perinatal depressive symptoms for future perinatal periods. A population-based sample of 2,178 women completed the Edinburgh Postnatal Depression Scale (EPDS) in the sec...

DRIVER (Chinese)

6

TNFalpha-Polymorphismus bei Patienten mit Sepsis und Schilddrüsenkarzinomen

Rossbach, Christiane

Das Zytokin Tumornekrosefaktor a (TNFa) hat einen entscheidenden Anteil an der Entwicklung schwerer Komplikationen, wie septischer Schock und Multiorganversagen nach Entwicklung einer Sepsis. Eine Assoziation des TNF2-Allels mit einem erhöhten TNF a Spiegel und einer höheren Mortalitätsrate wurde i...

DRIVER (Chinese)

8

Sequence variations in the transcriptional regulatory region and intron1 of HLA-DQB1 gene and their linkage in southern Chinese ethnic groups

Xu, Y; Hu, Q; Liu, Z; Shen, Y; Liu, X; Lin, B; Wu, Y; Chen, S; Xu, A

Sequence polymorphism in the transcriptional regulatory region extending to intron1 (DQRRI1) of HLA-DQB1 gene, and their haplotypic distributions were investigated in southern Chinese populations. We cloned and sequenced a 1.1-kb segment containing the transcriptional regulatory region, exon1, and p...

DRIVER (Chinese)

9

Sequence variations in the transcriptional regulatory region and intron1 of HLA-DQB1 gene and their linkage in southern Chinese ethnic groups

Xu, Y; Hu, Q; Liu, Z; Shen, Y; Liu, X; Lin, B; Wu, Y; Chen, S; Xu, A

Sequence polymorphism in the transcriptional regulatory region extending to intron1 (DQRRI1) of HLA-DQB1 gene, and their haplotypic distributions were investigated in southern Chinese populations. We cloned and sequenced a 1.1-kb segment containing the transcriptional regulatory region, exon1, and p...

DRIVER (Chinese)

11

Reduced RET expression in gut tissue of individuals carrying risk alleles of Hirschsprung's disease

Miao, X; Leon, TY-Y; Ngan, ES-W; So, M-T; Yuan, Z-W; Lui, VC-H; Chen, Y; Wong, KK-Y; Tam, PK-H; Garcia-Barceló, M

Receptor tyrosine kinase (RET) single nucleotide polymorphisms (SNPs) are associated with the Hirschsprung's disease (HSCR). We investigated whether the amount of RET expressed in the ganglionic gut of human was dependent on the genotype of three regulatory SNPs (-5G>A rs10900296 and -1A>C rs1090029...

DRIVER (Chinese)

12

Psychosocial risk factors associated with falls among Chinese community-dwelling older adults in Hong Kong

Leung, A; Chi, I; Lou, VWQ; Chan, KS

This study examined the relationship between psychosocial factors and falls among community-dwelling older adults in the Hong Kong Special Administrative Region of China. The study included 1573 adults aged 60 or above who lived at home and who were applying for long-term care services. These partic...

DRIVER (Chinese)

15

Molecular characterization of haemophilia A in southern Chinese

Chan, V; Pang, A; Chan, TPT; Chan, VWY; Chan, TK

41 unrelated southern Chinese haemophilia A patients were studied. The 5' promoter region, all 26 exons, their immediate 5' and 3' flanking splice junctions and the 3' untranslated region of the FVIII gene were amplified (including 16 different segments of exon 14) using GC-clamped primers. The GC-c...

DRIVER (Chinese)

19

Fine mapping of the 9q31 Hirschsprung’s disease locus

Tang, S. C.; Sribudiani, Y.; Miao, P. X.; Vries, R. A.; Burzynski, G.; So, T. M.; Leon, Y. Y.; Yip, H. B.; Osinga, J.

Hirschsprung’s disease (HSCR) is a congenital disorder characterised by the absence of ganglia along variable lengths of the intestine. The RET gene is the major HSCR gene. Reduced penetrance of RET mutations and phenotypic variability suggest the involvement of additional modifying genes in the dis...

DRIVER (Chinese)

22

Dose-dependent differences in the profile of mutations induced by an ultimate carcinogen from benzo[a]pyrene.

Jerina, D M; Yagi, H; Bhachech, N; Wei, S J; Preston, B D; Wong, C Q; Chang, R L; Cui, X X; Sayer, J M; Hennig, E

Mutations in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase (HPRT) gene of Chinese hamster V-79 cells were examined after exposure of the cells to a high cytotoxic dose (0.48 microM; 35% survival) and a low noncytotoxic dose (0.04 microM; 100% survival) of the ultimate car...

DRIVER (Chinese)

23

Catalog of 162 single nucleotide polymorphisms (SNPs) in a 4.7-kb region of the HLA-DP loci in southern Chinese ethnic groups

Liu, X; Liu, Z; Lin, B; Liu, Y; Chen, Z; He, W; Zhong, D; Xu, A

HLA class-II proteins are cell-surface molecules that present antigens to T cells, and their expressional regulation is crucial to the immune reaction. Sequence variation at the regulatory region can directly affect the gene expression level. We cloned and sequenced a 4.7-kb region containing the re...

DRIVER (Chinese)

24

Bone turnover markers and prediction of bone loss in elderly women

Lenora, Janaka

Around 70,000 osteoporosis-related fractures occur in Sweden annually and approximately half of the women in western world will sustain a fragility fracture after the age of 50 years. Fracture preventive efforts require the identification of individuals who are at high risk. Biochemical markers of b...

DRIVER (Chinese)

25

Beijing's Initiative on Cross-Border Insolvency: Reflections on a Recent Visit of Hong Kong Professionals to Beijing

Zhang, X; Booth, CD

In April 2001, a group of insolvency professionals from the Hong Kong Special Administrative Region visited Beijing and held a constructive meeting on cross-border insolvency with a delegation of Beijing government officials and insolvency professionals. The meeting was initiated by the Foreign Econ...

DRIVER (Chinese)

27

An atypical kindred with X-linked adrenal hypoplasia congenita, normal puberty, and normal Dax-1 promoter and coding sequence

Loke, KY; Poh, KSL; Walker, AP; Tan, JAMA; Tay, AHN

We report a Chinese kindred with an atypical sex-linked form of isolated adrenal hypoplasia without hypogonadotropic hypogonadism, Evidence of sex linkage was supported by DNA analysis using three polymorphic markers from the X-chromosome: a restriction fragment length polymorphism 200 kb centromeri...

DRIVER (Chinese)

28

An ancient balanced polymorphism in a regulatory region of human major histocompatibility complex is retained in Chinese minorities but lost worldwide

Liu, X; Fu, Y; Liu, Z; Lin, B; Xie, Y; Liu, Y; Xu, Y; Lin, J; Fan, X; Dong, M; Zeng, K; Wu, C-I; Xu, A

The coding regions of many of the major histocompatibility complex (MHC) (human leukocyte antigen [HLA] in humans) molecules are believed to be subject to balancing selection. But it is less certain whether the regulatory regions of such coding sequences are also subject to the same type of selectio...

DRIVER (Chinese)

29

An ancient balanced polymorphism in a regulatory region of human major histocompatibility complex is retained in Chinese minorities but lost worldwide

Liu, X; Fu, Y; Liu, Z; Lin, B; Xie, Y; Liu, Y; Xu, Y; Lin, J; Fan, X; Dong, M; Zeng, K; Wu, C-I; Xu, A

The coding regions of many of the major histocompatibility complex (MHC) (human leukocyte antigen [HLA] in humans) molecules are believed to be subject to balancing selection. But it is less certain whether the regulatory regions of such coding sequences are also subject to the same type of selectio...

DRIVER (Chinese)