Sample records for 辐射效应 (radiation effects)

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Radiosensitivity of Mammalian Cells: II. Radiation Effects on Macromolecular Synthesis

Walters, R. A.; Petersen, D. F.

Radiation effects on macromolecular synthesis essential for the Chinese hamster cell to traverse the life cycle and to divide have been investigated. Life-cycle analysis techniques employing inhibitors of macromolecular synthesis were used in determining the kinetics of cell growth for specific segm...

DRIVER (Chinese)


Quantitative and molecular analyses of genetic risk: a study with ionizing radiation.

An, J; Hsie, A W; Yu, Y; Xu, Z; Meltz, M L; Schwartz, J L; Hrelia, P

Mammalian cells in culture have been used to study the genetic effects of physical and chemical agents. We have used Chinese hamster ovary (CHO) cells, clone K1-BH4, to quantify mutations at the X-linked, large (35 kb) hypoxanthine-guanine phosphoribosyltransferase (hprt) locus (the CHO/HPRT assay) ...

DRIVER (Chinese)


On Microvascular Inflammation and Intestinal Leakage in Radiation Enteropathy

Röme, Andrada

Gastrointestinal tract damage is an insidious feature in patients undergoing radiotherapy. Microvascular inflammation, including leukocyte and platelet recruitment as well as epithelial barrier dysfunction, are considered to constitute key components in the pathophysiology of radiation-induced enter...

DRIVER (Chinese)


Molecular cloning of the human excision repair gene ERCC-6.

Troelstra, C.; Odijk, H.; Wit, J. de; Westerveld, A.; Thompson, L.H.; Bootsma, D.; Hoeijmakers, J.H.J.

The UV-sensitive, nucleotide excision repair-deficient Chinese hamster mutant cell line UV61 was used to identify and clone a correcting human gene, ERCC-6. UV61, belonging to rodent complementation group 6, is only moderately UV sensitive in comparison with mutant lines in groups 1 to 5. It harbors...

DRIVER (Chinese)


Localization of the nucleotide excision repair gene ERCC-6 to human chromosome 10q11-q21.

Troelstra, C.; Landsvater, R.M.; Wiegant, J.; Ploeg, M. van der; Viel, G.; Buys, C.H.C.M.; Hoeijmakers, J.H.J.

We have cloned the human DNA excision repair gene ERCC6 by virtue of its ability to correct the uv sensitivity of Chinese hamster overy cell mutant UV61. This mutant is a member of complementation group 6 of the nucleotide excision repair-deficient rodent mutants. By means of in situ hybridization a...

DRIVER (Chinese)


Laser Microirradiation of Chinese Hamster Cells at Wavelength 365 nm

Cremer, Thomas; Peterson, S. P.; Cremer, Christoph; Berns, Michael W.

Cells of a V79 subline of the Chinese hamster were microirradiated at wavelength 365 nm in the presence of the psoralen derivative, trioxsalen. Microirradiation was accomplished by a pulsed argon laser microbeam either in anaphase or in interphase 3 hr after mitosis. Inhibition of clonal growth and ...

DRIVER (Chinese)


Effects of Laser UV-Microirradiation (λ = 2573 A) on Proliferation of Chinese Hamster Cells

Cremer, Christoph; Cremer, Thomas; Zorn, Christian; Schoeller, L.

A laser uv-microbeam with a wavelength of 2573 Å having a minimum spot diameter of approx 0.5 μm was used to microirradiate interphase cells of a V-79 subline of Chinese hamster cells. The incident energy necessary to induce a significant decrease of proliferation was 30 to 60 times larger after mic...

DRIVER (Chinese)


Effects of Caffeine on Radiation-Induced Phenomena Associated with Cell-Cycle Traverse of Mammalian Cells

Walters, Ronald A.; Tobey, Robert A.; Gurley, Lawrence R.

Caffeine induced a state of G1 arrest when added to an exponentially growing culture of Chinese hamster cells (line CHO). In addition to its effect on cell-cycle traverse, caffeine ameliorated a number of the responses of cells to ionizing radiation. The duration of the division delay period followi...

DRIVER (Chinese)