Sample records for 嘧啶二聚物 (pyrimidine dimers)

Sample records 1 - 11 shown.


UVA-induced cyclobutane pyrimidine dimers form predominantly at thymine–thymine dipyrimidines and correlate with the mutation spectrum in rodent cells

Perdiz, Daniel; Rochette, Patrick J.; Drouin, Régen; Therrien, Jean-Philippe; Bastien, Nathalie; Drobetsky, Elliot A.

Ligation-mediated PCR was employed to quantify cyclobutane pyrimidine dimer (CPD) formation at nucleotide resolution along exon 2 of the adenine phosphoribosyltransferase (aprt) locus in Chinese hamster ovary (CHO) cells following irradiation with either UVA (340–400 nm), UVB (295–320 nm), UVC (254 ...

DRIVER (Chinese)


Human repair gene restores normal pattern of preferential DNA repair in repair defective CHO cells.

Hanawalt, P C; Bohr, V A; van Duin, M; Chu, E H; Okumoto, D S

The pattern of preferential DNA repair of UV-induced pyrimidine dimers was studied in repair-deficient Chinese hamster ovary (CHO) cells transfected with the human excision repair gene, ERCC-1. Repair efficiency was measured in the active dihydrofolate reductase (DHFR) gene and in its flanking, non-...

DRIVER (Chinese)


Demethylation enhances removal of pyrimidine dimers from the overall genome and from specific DNA sequences in Chinese hamster ovary cells.

Ho, L; Hanawalt, P C; Bohr, V A

We have examined the effects of changes in cytosine methylation on DNA repair in UV-irradiated Chinese hamster ovary (CHO) cells. A hypomethylated derivative of the CHO K1B11 line, B11aza, was established by passaging B11 cells over several months in increasing concentrations of 5-azacytidine; great...

DRIVER (Chinese)