Sample records for 芘 (pyrene)

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PAH–DNA Adducts in Cord Blood and Fetal and Child Development in a Chinese Cohort

Chen, Yu-hui; Tang, Deliang; Liu, Jason J.; Li, Tin-yu; Qu, Lirong; Perera, Frederica

Polycyclic aromatic hydrocarbons (PAHs) are an important class of toxic pollutants released by fossil fuel combustion. Other pollutants include metals and particulate matter. PAH–DNA adducts, or benzo[a]pyrene (BaP) adducts as their proxy, provide a chemical-specific measure of individual biological...

DRIVER (Chinese)


Induction of Ouabain-resistant Mutation and Sister Chromatid Exchanges in Chinese Hamster Cells with Chemical Carcinogens Mediated by Human Pulmonary Macrophages

Trump, Benjamin F.; Hsu, Ih Chang; Yamaguchi, Maria; Harris, Curtis C.; Schafer, Paul W.

Pulmonary macrophages (PAM) metabolically activated benzo[a]pyrene [B(a)P] and its proximate carcinogenic metabolite, (±)trans 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (7,8-diol), to ultimate mutagens that were detected in cocultivated Chinese hamster V79 cells. Increases in the frequency of ouabainr...

DRIVER (Chinese)


Dose-dependent differences in the profile of mutations induced by an ultimate carcinogen from benzo[a]pyrene.

Jerina, D M; Yagi, H; Bhachech, N; Wei, S J; Preston, B D; Wong, C Q; Chang, R L; Cui, X X; Sayer, J M; Hennig, E

Mutations in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase (HPRT) gene of Chinese hamster V-79 cells were examined after exposure of the cells to a high cytotoxic dose (0.48 microM; 35% survival) and a low noncytotoxic dose (0.04 microM; 100% survival) of the ultimate car...

DRIVER (Chinese)


Both replication bypass fidelity and repair efficiency influence the yield of mutations per target dose in intact mammalian cells induced by benzo[a]pyrene-diol-epoxide and dibenzo[a,l]pyrene-diol-epoxide.

Lagerqvist, Anne; Hakansson, Daniel; Prochazka, Gabriela; Lundin, Cecilia; Dreij, Kristian; Segerback, Dan; Jernstrom, Bengt

Mutations induced by polycyclic aromatic hydrocarbons (PAH) are expected to be produced when error-prone DNA replication occurs across unrepaired DNA lesions formed by reactive PAH metabolites such as diol epoxides. The mutagenicity of the two PAH-diol epoxides (+)-anti-7,8-dihydroxy-9,10-epoxy-7,8,...

DRIVER (Chinese)