Sample records for 核扩散 (proliferation)

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The expression of hGCN5 in burkitt lymphma Daudi cells and effets of TSA rgulating cell antiproliferation and apoptosis

Liu, H; Chen, Y; Li, X

Objective: To investigate the effect of TSA (Trichostatin A) regulating hGCN5 (human general control of amino acid synthesis protein 5) in B-NHL cell line Daudi cells, and to study anti-proliferation molecular machenism of TSA on B-NHL. Methods: The cell proliferation was measured by MTT assay. The ...

DRIVER (Chinese)


TNFalpha-Polymorphismus bei Patienten mit Sepsis und Schilddrüsenkarzinomen

Rossbach, Christiane

Das Zytokin Tumornekrosefaktor a (TNFa) hat einen entscheidenden Anteil an der Entwicklung schwerer Komplikationen, wie septischer Schock und Multiorganversagen nach Entwicklung einer Sepsis. Eine Assoziation des TNF2-Allels mit einem erhöhten TNF a Spiegel und einer höheren Mortalitätsrate wurde i...

DRIVER (Chinese)


Roles of paroxetine and corticosterone on adult mammalian retinal ciliary body cell proliferation

Wang, H; Lau, BWM; Yau, SY; Li, SY; Leung, N; Wang, NL; Tang, SW; Lee, TMC; So, KF

BACKGROUND: The neurogenesis in retina of adult mammals is generally abolished, and this renders the retina lack of regenerative capacity. Despite this, there is a small population of nestin-positive cells in the ciliary epithelium which retains neurogenic potential. The present study aimed at inves...

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Regulation of gambogic acid on hERG potassium channel protein of K562 leukemia cells

Cui, G-H; Shu, W-X; Wu, Q; Chen, Y

Objective: To explore the effects of gambogic acid (GA) on proliferation, apoptosis, and cell cycle distribution of leukemia cells K562, as well as to observe its regulation on the expression of human ether-à-go-go related genes (hKRG) protein. Methods: K562 Cells were treated with various concentra...

DRIVER (Chinese)


On Microvascular Inflammation and Intestinal Leakage in Radiation Enteropathy

Röme, Andrada

Gastrointestinal tract damage is an insidious feature in patients undergoing radiotherapy. Microvascular inflammation, including leukocyte and platelet recruitment as well as epithelial barrier dysfunction, are considered to constitute key components in the pathophysiology of radiation-induced enter...

DRIVER (Chinese)


Large granular lymphocyte leukemia: a study of nine cases in a Chinese population

Kwong, YL; Wong, KF; Chan, LC; Liang, RHS; Chan, JKC; Lin, CK; Chan, TK

Large granular lymphocyte (LGL) leukemia is a neoplastic disorder of lymphocytes that is characterized by the presence of prominent cytoplasmic granules, and involves the proliferation of at least two distinct cell types, T cells and natural killer (NK) cells. The authors report the clinical and pat...

DRIVER (Chinese)


Inhibition of p38 Mitogen-Activated Protein Kinase Augments Lipopolysaccharide-Induced Cell Proliferation in CD14-Expressing Chinese Hamster Ovary Cells

Koide, Naoki; Chakravortty, Dipshikha; Sugiyama, Tsuyoshi; Kato, Yutaka; Mu, Mya Mya; Yoshida, Tomoaki; Yokochi, Takashi

CD14-expressing Chinese hamster ovary (CD14-CHO) cells, established by transfection of human CD14 DNA, acquired high responsiveness to lipopolysaccharide (LPS) through membrane-bound CD14 expression. LPS induced DNA synthesis and activated a series of mitogen-activated protein (MAP) kinases, extrace...

DRIVER (Chinese)


Galectin binding proteins in serum and bronchoalveolar lavage -in healthy and pathological conditions

Cederfur, Cecilia

Galectins are carbohydrate binding proteins, implicated in conditions of both inflammation and cancer. Connections between chronic inflammation and cancer are proposed by the increased remodelling and proliferation that occurs, leading to enhanced survival and proliferation of malignant cells. Since...

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Effects of Laser UV-Microirradiation (λ = 2573 A) on Proliferation of Chinese Hamster Cells

Cremer, Christoph; Cremer, Thomas; Zorn, Christian; Schoeller, L.

A laser uv-microbeam with a wavelength of 2573 Å having a minimum spot diameter of approx 0.5 μm was used to microirradiate interphase cells of a V-79 subline of Chinese hamster cells. The incident energy necessary to induce a significant decrease of proliferation was 30 to 60 times larger after mic...

DRIVER (Chinese)


Effect on proliferation and apoptosis in RPM1-8226 human myeloma cells and regulation on steroid receptor coactivator-3 by deguelin

Li, R; Chen, Y; Shu, W-X

Objective: To investigate the effects of deguelin on the proliferation inhibition and apoptosis induction in RPMI-8226 cells in vitro, as well as the regulation of steroid receptor coactivator-3 (SRC-3) to explore the relationship between them. Methods: The effect of deguelin on the growth of RPMI-8...

DRIVER (Chinese)


Effect on proliferation and apoptosis and regulation on nucleoporin Nup88 in acute leukemic cell U937 by gambogic acid

Shu, W-X; Chen, Y; He, J; Cui, G-H

Objective: To investigate the effect on proliferation and apoptosis and the regulation on nucleoporin Nup88 in acute leukemic cell U937 by gambogic acid (GA) in vitro. To study the relationship between the effect and the regulation. Methods: The effect of GA on the growth of U937 cells was studied b...

DRIVER (Chinese)


Effect of deguelin on expression of nup98 in K562 cells

Wu, QL; Chen, Y; Chen, WH; He, J

The study was purposed to investigate the effect of deguelin on expression of nucleoporin 98 (nup98) in leukemia K562 cells. MTT assay was used to assess the effects of deguelin on cell proliferation. FCM and RT-PCR were used to analyze the changes of nup98 mRNA and protein in K562 cells after treat...

DRIVER (Chinese)


Effect of curcumin on acetylation of histone H3 in human lymphoma cell line Raji

Li, XG; Chen, Y; Wu, Q; Sun, CY

BACKGROUND & OBJECTIVE: Epigenetic change is an important mechanism of oncogenesis. The inhibitors of methyltransferases and deacetylases, with epigenetic modificative effects, could inhibit proliferation and induce apoptosis of tumor cells. This study was to investigate the effects of curcumin on t...

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Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of phosphoinositide-specific phospholipase C.

Seuwen, K; Pouysségur, J; Lagarde, A

Stable expression of high levels of activated forms of Haras (T24) or v-Ki-ras by transfection of Chinese hamster lung fibroblasts (CCL39) yielded cells highly tumorigenic in nude mice. Two classes of transformed cells were distinguished, one with moderate p21 expression (10-fold increased) had reta...

DRIVER (Chinese)


Chemopreventive effects of rofecoxib and folic acid on gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats.

Fei, Su Juan; Xiao, Shu Dong; Peng, Yan Shen; Chen, Xiao Yu; Shi, Yao

Dietary modulation of cancer & cancer biomarkers; Dietary modulation of carcinogenesis-related pathways. Dietary item or component studied: rofecoxib; folic acid. Outcome studied: gastric cancer; proliferating cell nuclear antigen (PCNA)Study type: male Wistar rats Tissue/biological material/sample...

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Cell viability on functionalized diamond surfaces : towards non-invasive monitoring of cell characteristics


In this report both qualitative and quantitative results on cell viability of Chinese hamster ovary (CHO) cells cultured on bare, well-characterized nano- and microcrystalline diamond surfaces, either hydrogen or oxygen terminated, are presented and discussed. CHO cells stably transfected with homom...

DRIVER (Chinese)


Cell Proliferation and DNA Breaks Are Involved in Ultraviolet Light-induced Apoptosis in Nucleotide Excision Repair-deficient Chinese Hamster Cells

Dunkern, Torsten R.; Kaina, Bernd

UV light targets both membrane receptors and nuclear DNA, thus evoking signals triggering apoptosis. Although receptor-mediated apoptosis has been extensively investigated, the role of DNA damage in apoptosis is less clear. To analyze the importance of DNA damage induced by UV-C light in apoptosis, ...

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Antibody-Mediated Neutralization of Pertussis Toxin-Induced Mitogenicity of Human Peripheral Blood Mononuclear Cells

Ward, Joel I.; Millen, Scott H.; Connelly, Beverly; Bernstein, David I.; Chang, Swei-Ju; Weiss, Alison A.

Antibody-mediated neutralization of pertussis toxin-induced proliferation of human peripheral blood mononuclear cells (PBMC) was assessed using alamarBlue and compared with results from the Chinese hamster ovary (CHO) cell assay using sera from vaccinated adults and convalescent children. Neutraliza...

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Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene.

Caron, M G; Seuwen, K; Kobilka, B K; Magnaldo, I; Regan, J W; Lefkowitz, R J; Pouysségur, J

To test the hypothesis that agents activating receptors negatively coupled to adenylyl cyclase (AC) can stimulate cell proliferation, we have expressed a human alpha 2-adrenergic receptor (alpha 2-C10) in CCL39 cells and studied the effects of alpha 2-agonists on reinitiation of DNA synthesis in qui...

DRIVER (Chinese)