Sample records for 聚合酶链反应 (polymerase chain reaction)
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81

p53 mutations in non-small cell lung carcinomas in Hong Kong

Lung, ML; Wong, MP; Skaanild, MT; Fok, CL; Lam, WK; Yew, WW

Lung resections from 50 Chinese patients in Hong Kong diagnosed as having non-small cell lung carcinoma were examined for the presence of mutations in the p53 gene by polymerase chain reaction single-stranded conformation polymorphism methods and for aberrant protein expression by immunostaining tec...

DRIVER (Chinese)

85

Reduced RET expression in gut tissue of individuals carrying risk alleles of Hirschsprung's disease

Miao, X; Leon, TY-Y; Ngan, ES-W; So, M-T; Yuan, Z-W; Lui, VC-H; Chen, Y; Wong, KK-Y; Tam, PK-H; Garcia-Barceló, M

Receptor tyrosine kinase (RET) single nucleotide polymorphisms (SNPs) are associated with the Hirschsprung's disease (HSCR). We investigated whether the amount of RET expressed in the ganglionic gut of human was dependent on the genotype of three regulatory SNPs (-5G>A rs10900296 and -1A>C rs1090029...

DRIVER (Chinese)

92

Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese

Yao, Y; Man, X; Li, X; Luo, H; Mao, C; Zhang, Y

Methods: C4 null genes were determined by a polymerase chain reaction (PCR) procedure with sequence specific primers (PCR-SSP). The 2 bp insertion in exon 29, which was previously identified in non-Chinese populations and caused defective C4A genes, was directly typed by sequencing the whole exon 29...

DRIVER (Chinese)

95

N-ras mutations in myelodysplastic syndromes in Hong Kong Chinese

Leung, P; Chan, LC; Liang, RHS

Hong Kong Chinese patients with myelodysplastic syndromes were screened for the presence of N-ras mutation by using the polymerase chain reaction/dot blot hybridization technique. Three of 20 (15%) cases studied were found to harbour mutant N-ras in the bone marrow mononuclear cell population. One c...

DRIVER (Chinese)

96

Methylation of INK4 and CIP/KIP families of cyclin-dependent kinase inhibitor in chronic lymphocytic leukaemia in Chinese patients

Chim, CS; Fung, TK; Wong, KF; Lau, JS; Law, M; Liang, R

BACKGROUND: INK4 (p15, p16, p18 and p19) and CIP/KIP (p21, p27 and p57) are two families of cyclin-dependent kinase inhibitors (CKI) targeting CDK4/6 and CDK2, respectively. AIM: To study the role of methylation in the inactivation of CKI in chronic lymphocytic leukaemia (CLL). MATERIALS AND METHODS...

DRIVER (Chinese)

99

HLA class II alleles in Chinese patients with hepatocellular carcinoma

Donaldson, PT; Ho, S; Williams, R; Johnson, PJ

BACKGROUND/AIMS: Recent reports of an association between human leucocyte antigens (HLA) and persistence of hepatitis B virus infection, and the familial clustering of hepatocellular carcinoma raise the question of genetic susceptibility. Previous studies have been limited to serological phenotyping...

DRIVER (Chinese)

101

Galectin binding proteins in serum and bronchoalveolar lavage -in healthy and pathological conditions

Cederfur, Cecilia

Galectins are carbohydrate binding proteins, implicated in conditions of both inflammation and cancer. Connections between chronic inflammation and cancer are proposed by the increased remodelling and proliferation that occurs, leading to enhanced survival and proliferation of malignant cells. Since...

DRIVER (Chinese)

117

Comparison of the HbH inclusion test and a PCR test in routine screening for alpha thalassaemia in Hong Kong.

Chan, A Y; Chan, L C; So, C K

AIM: To compare the haemoglobin (Hb) H inclusion test with a polymerase chain reaction (PCR) test in routine screening for alpha thalassaemia. METHODS: Ninety nine peripheral blood samples from Chinese patients with mean corpuscular volume below 80 fl were screened for alpha thalassaemia using the H...

DRIVER (Chinese)

118

Comparison of the HbH inclusion test and a PCR test in routine screening for alpha thalassaemia in Hong Kong

Chan, AYY; So, CKC; Chan, LC

AIM: To compare the haemoglobin (Hb) H inclusion test with a polymerase chain reaction (PCR) test in routine screening for alpha thalassaemia. METHODS: Ninety nine peripheral blood samples from Chinese patients with mean corpuscular volume below 80 fl were screened for alpha thalassaemia using the H...

DRIVER (Chinese)

120

Association of pure red cell aplasia with T large granular lymphocyte leukaemia

Kwong, YL; Wong, KF

AIM: To define the relation between T large granular lymphocyte (T-LGL) leukaemia and pure red cell aplasia in Chinese patients. METHODS: Patients with T-LGL leukaemia were identified from a consecutive series of Chinese patients with chronic lymphoproliferative disorders. The diagnosis of T-LGL leu...

DRIVER (Chinese)

121

Aberrante Methylierung des p16INK4a-Promotors als Tumormarker für die molekularzytologische Diagnostik des Lungenkarzinoms an Bronchialaspiraten

Krücken, Anne

In der vorliegenden Arbeit wurde der Methylierungsstatus des p16INK4a-Promotors an Material der pulmonalen Exfoliativzytologie untersucht und seine Eignung als Tumormarker für die molekularzytologische Diagnostik des Lungenkarzinoms überprüft. Der Nachweis der p16INK4a-Promotor-Methylierung erfolgte...

DRIVER (Chinese)

122

A laboratory strategy for genotyping haemoglobin H disease in the Chinese

Chan, AYY; So, CC; Ma, ESK; Chan, LC

BACKGROUND: The thalassaemias are the commonest blood disorders worldwide, with South East Asia and southern China as areas of high prevalence. Accurate diagnosis of these disorders helps in clinical management with improved outcome. METHODS: The alpha-globin genotypes of 100 Chinese patients in Hon...

DRIVER (Chinese)

123

Tsui, Wai-yan; 徐慧恩

DRIVER (Chinese)

124

Ng, Sau-wah; 吳秀華

DRIVER (Chinese)

125

Chung, Man-kin; 鍾文健

DRIVER (Chinese)