Sample records for 发病机理 (pathogenesis)

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cagA-Positive Helicobacter pylori Populations in China and The Netherlands Are Distinct

van der Hulst, René W. M.; van der Ende, Arie; Bart, Aldert; Pan, Zhi-Jun; Feller, Monique; Dankert, Jacob; Xiao, Shu-Dong

The aim of this research was to study whether and to what extent Chinese cagA-positive Helicobacter pylori isolates differ from those in The Netherlands. Analysis of random amplified polymorphic DNA (RAPD)-PCR-assessed DNA fingerprints of chromosomal DNA of 24 cagA-positive H. pylori isolates from D...

DRIVER (Chinese)


Translocation of ExsE into Chinese Hamster Ovary Cells Is Required for Transcriptional Induction of the Pseudomonas aeruginosa Type III Secretion System▿

Urbanowski, Mark L.; Yahr, Timothy L.; Brutinel, Evan D.

Transcription of the Pseudomonas aeruginosa type III secretion system (T3SS) is induced under Ca2+-limiting growth conditions or following the contact of the bacteria with host cells. The regulatory response to low Ca2+ levels is initiated by the T3SS-mediated secretion of ExsE, a negative regulator...

DRIVER (Chinese)


Three hamster species with different scrapie incubation times and neuropathological features encode distinct prion proteins.

McKinley, M P; Lowenstein, D H; Westaway, D; Butler, D A; DeArmond, S J; Prusiner, S B

Given the critical role of the prion protein (PrP) in the transmission and pathogenesis of experimental scrapie, we investigated the PrP gene and its protein products in three hamster species, Chinese (CHa), Armenian (AHa), and Syrian (SHa), each of which were found to have distinctive scrapie incub...

DRIVER (Chinese)


TNFalpha-Polymorphismus bei Patienten mit Sepsis und Schilddrüsenkarzinomen

Rossbach, Christiane

Das Zytokin Tumornekrosefaktor a (TNFa) hat einen entscheidenden Anteil an der Entwicklung schwerer Komplikationen, wie septischer Schock und Multiorganversagen nach Entwicklung einer Sepsis. Eine Assoziation des TNF2-Allels mit einem erhöhten TNF a Spiegel und einer höheren Mortalitätsrate wurde i...

DRIVER (Chinese)


Study progress in therapeutic effects of traditional Chinese medicine monomer in severe acute pancreatitis*

Zhang, Xi-ping; Shi, Yan; Liu, Da-ren

Severe acute pancreatitis (SAP) is a common acute abdomen clinical problem characterized by high mortality, multiple complications, complicated pathogenesis and difficult treatment. Recent studies found traditional Chinese medicine (TCM) monomers have markedly good effect for treating SAP. Many TCM ...

DRIVER (Chinese)


Role of Lactosyl Glycan Sequences in Inhibiting Enteropathogenic Escherichia coli Attachment

Vanmaele, Rosa P.; Armstrong, Glen D.; Heerze, Louis D.

Previously, we found that asialo-lactosamine sequences served as receptors for enteropathogenic Escherichia coli (EPEC) binding to Chinese hamster ovary (CHO) cells. In the present report, we have extended these earlier results by examining the ability of lactosamine- or fucosylated lactosamine-bovi...

DRIVER (Chinese)


Purification and Characterization of Novel Toxin Produced by Vibrio cholerae O1

Nair, G. B.; Walia, Kamini; Singh, Harminder; Ghosh, Sujata; Ghosh, Amit; Ganguly, Nirmal Kumar; Sahni, Girish; Vohra, Harpreet

Vibrio cholerae WO7 (serogroup O1) isolated from patients with diarrhea produces an extracellular toxin despite the absence of ctx, zot, and ace genes from its genome. The toxin elongates Chinese hamster ovary cells, produces fluid accumulation in ligated rabbit ileal loops, and agglutinates freshly...

DRIVER (Chinese)


Prolactin profile in a cohort of Chinese systemic lupus erythematosus patients

Mok, CC; Lau, CS; Tam, SCF

Prolactin (PRL) is an important immunoregulatory hormone secreted by the anterior pituitary gland. Hyperprolactinaemia has been implicated in the pathogenesis of systemic lupus erythematosus (SLE). However, clinical studies regarding the PRL level and lupus disease activity have yielded contradictor...

DRIVER (Chinese)


Polymorphisms and Functional Analysis of CCR5 Gene in Southern Chinese HIV Patients and Healthy Controls.

Zhao, X; Lee, SS; Wong, KH; Chan, KCW; Ng, F; Chan, CS; Yam, WC; Yuen, KY; Ng, MH; Zheng, B

DRIVER (Chinese)


Luminal bacteria and proteases together decrease adherence of Entamoeba histolytica trophozoites to Chinese hamster ovary epithelial cells: a novel host defence against an enteric pathogen.

Variyam, E P

BACKGROUND: Factors that prevent colonic mucosal invasion by pathogenic Entamoeba histolytica are not understood. A key initial step in pathogenesis of injury induced by amoeba is adherence to target cells mediated by a surface glycoprotein lectin on E histolytica. Mucin degrading bacteria normally ...

DRIVER (Chinese)


Isolation and Characterization of a Mutant Chinese Hamster Ovary Cell Line That Is Resistant to Chlamydia trachomatis Infection at a Novel Step in the Attachment Process

Carabeo, Reynaldo A.; Hackstadt, Ted

Host factors involved in Chlamydia trachomatis pathogenesis were investigated by random chemical mutagenesis of Chinese hamster ovary (CHO-K1) cells followed by selection for clones resistant to chlamydial infection. A clonal mutant cell line, D4.1–3, refractory to infection by the C. trachomatis L2...

DRIVER (Chinese)


Fine mapping of the 9q31 Hirschsprung’s disease locus

Tang, S. C.; Sribudiani, Y.; Miao, P. X.; Vries, R. A.; Burzynski, G.; So, T. M.; Leon, Y. Y.; Yip, H. B.; Osinga, J.

Hirschsprung’s disease (HSCR) is a congenital disorder characterised by the absence of ganglia along variable lengths of the intestine. The RET gene is the major HSCR gene. Reduced penetrance of RET mutations and phenotypic variability suggest the involvement of additional modifying genes in the dis...

DRIVER (Chinese)


Differential expression of microRNAs in the placentae of Chinese patients with severe pre-eclampsia

Hu, Yali; Li, Pengfei; Hao, Sha; Liu, Liu; Zhao, Junli; Hou, Yayi

Background: The pathogenesis of pre-eclampsia (PE) is incompletely understood. The placenta is considered to play a key role in this disease. Recent research showed that many microRNAs (miRNAs) are expressed in human placenta. Our aim in this study was to determine differential expression of miRNAs ...

DRIVER (Chinese)


Comparison of the Replication of Influenza A Viruses in Chinese Ring-Necked Pheasants and Chukar Partridges

Humberd, Jennifer; Webster, Robert G.; Guan, Yi

We investigated the replication and transmission of avian influenza A viruses in two species thought to be intermediate hosts in the spread of influenza A viruses in live poultry markets: Chinese ring-necked pheasants and chukar partridges. All 15 hemagglutinin subtypes replicated in pheasants, and ...

DRIVER (Chinese)


Clinical and pathological characteristics of Chinese patients with BRCA related breast cancer

Kwong, Ava; Wong, P. L.; Wong, N. H.; Law, F. B. F.; Ng, O. K. E.; Tang, H. Y.; Chan, K. W.; Suen, K. T. D.; Choi, C.

Breast cancers related to BRCA mutations are associated with particular biological features. Here we report the clinical and pathological characteristics of breast cancer in Chinese women with and without BRCA mutations and of carriers of BRCA1 mutations compared to BRCA2 mutations. Two hundred and ...

DRIVER (Chinese)


CD4+ T-Cell Responses to Epstein-Barr Virus Nuclear Antigen EBNA1 in Chinese Populations Are Highly Focused on Novel C-Terminal Domain-Derived Epitopes

Rickinson, A. B.; Taylor, G. S.; Tsang, C. W.; Gudgeon, N. H.; Lin, X.; Jia, H.; Lin, C. K.; Hui, E. P.; Chan, A. T. C.

Epstein-Barr virus nuclear antigen EBNA1, the one viral protein uniformly expressed in nasopharyngeal carcinoma (NPC), represents a prime target for T-cell-based immunotherapy. However, little is known about the EBNA1 epitopes, particularly CD4 epitopes, presented by HLA alleles in Chinese people, t...

DRIVER (Chinese)


Bone turnover markers and prediction of bone loss in elderly women

Lenora, Janaka

Around 70,000 osteoporosis-related fractures occur in Sweden annually and approximately half of the women in western world will sustain a fragility fracture after the age of 50 years. Fracture preventive efforts require the identification of individuals who are at high risk. Biochemical markers of b...

DRIVER (Chinese)


Acute infection of Chinese macaques by a CCR5-tropic SHIV carrying a primary HIV-1 subtype B’ envelope

Wang, H; Zhuang, K; Liu, L; Tang, Z; Tang, J; Tien, P; Zhang, L; Chen, Z

The increasing prevalence of HIV-1 subtype B' in China and Southeast Asia calls for efforts to develop a relevant animal model to study viral transmission and pathogenesis. Because there are significant differences between subtype B' HIV-1 and other chimeric simian/human immunodeficiency viru (SHIVs...

DRIVER (Chinese)


Absence of Epstein-Barr virus in oesophageal squamous cell carcinoma

Ma, L; Lam, K Y; Leung, M L; Srivastava, G

Aim—To identify the possible role of Epstein-Barr virus (EBV), in Chinese patients, in the pathogenesis of oesophageal squamous cell carcinoma.

DRIVER (Chinese)


Absence of Epstein-Barr virus in oesophageal squamous cell carcinoma

Lam, AKY; Srivastava, G; Leung, ML; Ma, L

Aim-To identify the possible role of Epstein-Barr virus (EBV), in Chinese patients, in the pathogenesis of oesophageal squamous cell carcinoma.Methods-Formalin fixed, paraffin wax embedded tissues from 74 cases of oesophageal squamous cell carcinoma (28 with well differentiated, 27 with moderately d...

DRIVER (Chinese)


A novel intronic polymorphism of ABCA1 gene reveals risk for sporadic Alzheimer's disease in Chinese

Leung, WC; Li, Y; Li, Z; Tang, AYB; Cheung, BMY; Leung, RYH; Yik, P-Y; Jin, D-Y; Song, Y-Q

Recent genetic studies have shown that variants of the ATP-binding cassette transporter A1, ABCA1, may be implicated in the pathogenesis of Alzheimer's disease (AD). In this case-control study, a panel of 19 single nucleotide polymorphisms (SNP) (including three amino-acid-coding SNPs used for repli...

DRIVER (Chinese)


A novel genetic study of Chinese families with autosomal recessive retinitis pigmentosa

El-Aziz, MMA; El-Ashry, MF; Chan, WM; Chong, KL; Barragan, I; Antinolo, G; Pang, CP; Bhattacharya, SS

Autosomal recessive retinitis pigmentosa (arRP) is the commonest form of RP worldwide. To date 22 loci have been implicated in the pathogenesis of this disease; however none of these loci independently account for a significant proportion of recessive RP. Linkage studies of arRP in consanguineous fa...

DRIVER (Chinese)


Röme, Andrada

Gastrointestinal tract damage is an insidious feature in patients undergoing radiotherapy. Microvascular inflammation, including leukocyte and platelet recruitment as well as epithelial barrier dysfunction, are considered to constitute key components in the pathophysiology of radiation-induced enter...

DRIVER (Chinese)