Sample records for 多环芳香烃 (pah)

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PAH–DNA Adducts in Cord Blood and Fetal and Child Development in a Chinese Cohort

Chen, Yu-hui; Tang, Deliang; Liu, Jason J.; Li, Tin-yu; Qu, Lirong; Perera, Frederica

Polycyclic aromatic hydrocarbons (PAHs) are an important class of toxic pollutants released by fossil fuel combustion. Other pollutants include metals and particulate matter. PAH–DNA adducts, or benzo[a]pyrene (BaP) adducts as their proxy, provide a chemical-specific measure of individual biological...

DRIVER (Chinese)


Identification of a novel phenylketonuria (PKU) mutation in the Chinese: further evidence for multiple origins of PKU in Asia.

Lo, W H; Wang, T; Eisensmith, R C; Okano, Y; Huang, S Z; Zeng, Y T; Woo, S L

A novel mutation has been identified in the human phenylalanine hydroxylase (PAH) gene of a Chinese patient with classical phenylketonuria (PKU). It is a single base transition of G to A at the last base in intron 4 of the gene, which abolishes the 3'-acceptor site of the intron. Population screenin...

DRIVER (Chinese)


Both replication bypass fidelity and repair efficiency influence the yield of mutations per target dose in intact mammalian cells induced by benzo[a]pyrene-diol-epoxide and dibenzo[a,l]pyrene-diol-epoxide.

Lagerqvist, Anne; Hakansson, Daniel; Prochazka, Gabriela; Lundin, Cecilia; Dreij, Kristian; Segerback, Dan; Jernstrom, Bengt

Mutations induced by polycyclic aromatic hydrocarbons (PAH) are expected to be produced when error-prone DNA replication occurs across unrepaired DNA lesions formed by reactive PAH metabolites such as diol epoxides. The mutagenicity of the two PAH-diol epoxides (+)-anti-7,8-dihydroxy-9,10-epoxy-7,8,...

DRIVER (Chinese)