Sample records for 乌巴因 (ouabain)

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Transfer of codominant markers by isolated metaphase chromosomes in Chinese hamster ovary cells.

Spandidos, D A; Siminovitch, L

Codominant mutations to methotrexate and ouabain resistance in Chinese hamster ovary cells can be transferred to recipient Chinese hamster ovary cells by isolated metaphase chromosomes. For methotrexate, both the structural change and the increased activity of dihydrofolate reductase (5,6,7,8-tetrah...

DRIVER (Chinese)


Induction of Thioguanine- and Ouabain-Resistant Mutants and Single-Strand Breaks in the DNA of Chinese Hamster Ovary Cells by 3H-Thymidine

Cleaver, James E.

Cultured Chinese hamster cells were labeled with 6-3H-thymidine or 5-methyl-3H-thymidine and allowed to accumulate damage from 3H decays for various periods of time while frozen. The frequencies of cells resistant to 6-thioguanine or ouabain and the amount of DNA damage (i.e., number of single-stran...

DRIVER (Chinese)


Induction of Ouabain-resistant Mutation and Sister Chromatid Exchanges in Chinese Hamster Cells with Chemical Carcinogens Mediated by Human Pulmonary Macrophages

Trump, Benjamin F.; Hsu, Ih Chang; Yamaguchi, Maria; Harris, Curtis C.; Schafer, Paul W.

Pulmonary macrophages (PAM) metabolically activated benzo[a]pyrene [B(a)P] and its proximate carcinogenic metabolite, (±)trans 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (7,8-diol), to ultimate mutagens that were detected in cocultivated Chinese hamster V79 cells. Increases in the frequency of ouabainr...

DRIVER (Chinese)


Bromodeoxyuridine-Induced Mutations in Synchronous Chinese Hamster Cells: Temporal Induction of 6-Thioguanine and Ouabain Resistance during DNA Replication

Burki, H. John; Aebersold, Paul M.

Mutations were induced in synchronous Chinese hamster cells by bromodeoxyuridine (BUdR) incorporated into cells for one-hour periods in the cell cycle. There was a very pronounced temporal dependence during the first half of the DNA synthesis period for the induction of damage leading to 6-thioguani...

DRIVER (Chinese)