Sample records for 自然杀伤细胞 (nk cells)

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The natural killer gene complex genetic locus Chok encodes Ly-49D, a target recognition receptor that activates natural killing

Ortaldo, John R.; Idris, Azza H.; Mason, Llewellyn H.; Smith, Hamish R. C.; Scalzo, Anthony A.; Yokoyama, Wayne M.

Previously, we established that natural killer (NK) cells from C57BL/6 (B6), but not BALB/c, mice lysed Chinese hamster ovary (CHO) cells, and we mapped the locus that determines this differential CHO-killing capacity to the NK gene complex on chromosome 6. The localization of Chok in the NK gene co...

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Lysis of Chinese hamster embryo fibroblast mutants by human natural cytotoxic (NK) cells.

Yunis, E J; Dubey, D P; Smith, B L; Staunton, D E; Sager, R

The nontransformed, nontumorigenic CHEF/18 Chinese hamster embryo fibroblast line, as well as nontumorigenic CHEF/18 mutants that had become anchorage independent or acquired a reduced serum requirement for growth, and fully transformed, tumorigenic CHEF cell lines were analyzed for their sensitivit...

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Leptin signaling protects NK cells from apoptosis during development in mouse bone marrow

Lo, CKC; Lam, QLK; Yang, M; Ko, KH; Sun, L; Ma, R; Wang, S; Xu, H; Tam, S; Wu, CY; Zheng, BJ; Lu, L

Increasing evidence indicates a role of leptin in immune response, but it remains largely unclear whether leptin signaling is involved in regulating NK cell development in the bone marrow (BM). In this study, we have characterized NK cell differentiation and maturation in the BM of leptin-receptor d...

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Aberrante Methylierung des p16INK4a-Promotors als Tumormarker für die molekularzytologische Diagnostik des Lungenkarzinoms an Bronchialaspiraten

Krücken, Anne

In der vorliegenden Arbeit wurde der Methylierungsstatus des p16INK4a-Promotors an Material der pulmonalen Exfoliativzytologie untersucht und seine Eignung als Tumormarker für die molekularzytologische Diagnostik des Lungenkarzinoms überprüft. Der Nachweis der p16INK4a-Promotor-Methylierung erfolgte...

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A staged approach with vincristine, adriamycin, and dexamethasone followed by bortezomib, thalidomide, and dexamethasone before autologous hematopoietic stem cell transplantation in the treatment of newly diagnosed multiple myeloma

Chim, C. S.; Lie, A. K. W.; Chan, E. Y. T.; Leung, Y. Y.; Cheung, S. C. W.; Chan, S. Y. T.; Liang, Raymond; Kwong, Y. L.

Bortezomib-based regimens have significant activities in multiple myeloma (MM). In this study, we tested the efficacy of a total therapy with a staged approach where newly diagnosed MM patients received vincristine/adriamycin/dexamethsone (VAD). VAD-sensitive patients (≥75% paraprotein reduction) re...

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