Sample records for 镍 (nickel)
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57

The role of nickel and nickel-mediated reactive oxygen species in the mechanism of nickel carcinogenesis.

Klein, C B; Huang, X; Frenkel, K; Zhuang, Z; Costa, M

Increasing evidence demonstrates the reactive oxygen species (ROS) are implicated in metal carcinogenesis. Exposure of cultured Chinese hamster ovary (CHO) cells to several nickel compounds, i.e. NiS, Ni3S2, NiO (black and green), and NiCl2 has been shown to increase oxidation of 2',7-dichlorofluore...

DRIVER (Chinese)

85

Nickel Ions Increase Histone H3 Lysine 9 Dimethylation and Induce Transgene Silencing

Yan, Yan; Chen, Haobin; Kluz, Thomas; Ke, Qingdong; Costa, Max

We have previously reported that carcinogenic nickel compounds decreased global histone H4 acetylation and silenced the gpt transgene in G12 Chinese hamster cells. However, the nature of this silencing is still not clear. Here, we report that nickel ion exposure increases global H3K9 mono- and dimet...

DRIVER (Chinese)

99

Loss of thrombospondin transcriptional activity in nickel-transformed cells.

Costa, M; Salnikow, K; Klein, C; Cosentino, S

mRNA from normal Chinese hamster embryo (CHE) cells was transcribed to cDNA and subtracted with an excess of mRNA from Chinese hamster embryo cells transformed by nickel compounds. Here we report the recovery of a sequence found to be highly homologous to the mouse thrombospondin 1 gene that was obt...

DRIVER (Chinese)

120

Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens.

Costa, M; Salnikow, K; Lee, Y W; Kargacin, B; Klein, C B; Kitahara, J; Christie, N T; Dowjat, K; Zhitkovich, A

A transgenic gpt+ Chinese hamster cell line (G12) was found to be susceptible to carcinogenic nickel-induced inactivation of gpt expression without mutagenesis or deletion of the transgene. Many nickel-induced 6-thioguanine-resistant variants spontaneously reverted to actively express gpt, as indica...

DRIVER (Chinese)

123

A Computer Simulation Study of the Effects of Anions on Nickel Carbonate Crystallization Process

Liu, F; de Leeuw, NH; Zhang, Z

Crystallization behaviors of nickel carbonate in different solutions are investigated via atomistic simulation technique. Simulation results show that the effect of hydration on the surface enables surface more stable and morphology more regular. The interaction between SO42- and crystal surface is ...

DRIVER (Chinese)

124

Nickel, Lukas; Zillich, Wolfgang

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DRIVER (Chinese)

125

Nickel, Lukas

DRIVER (Chinese)

126

Nickel, Lukas

DRIVER (Chinese)

127

Nickel, Lukas

DRIVER (Chinese)

128

Nickel , Lukas

DRIVER (Chinese)