Sample records for 神经元 (neurons)
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58

Stoichiometry of the glial glutamate transporter GLT-1 expressed inducibly in a Chinese hamster ovary cell line selected for low endogenous Na+-dependent glutamate uptake

Levy, LM; Warr, O; Attwell, D

Glutamate transport across the plasma membrane of neurons and glia is powered by the transmembrane electrochemical gradients for sodium, potassium, and pH, but there is controversy over the number of Na+ cotransported with glutamate. The stoichiometry of glutamate transporters is important because i...

DRIVER (Chinese)

59

Stoichiometry of expressed KCNQ2/KCNQ3 potassium channels and subunit composition of native ganglionic M channels deduced from block by tetraethylammonium

Hadley, JK; Passmore, GM; Tatulian, L; Al-Qatari, M; Ye, F; Wickenden, AD; Brown, DA

KCNQ2 and KCNQ3 potassium-channel subunits can form both homomeric and heteromeric channels; the latter are thought to constitute native ganglionic M channels. We have tried to deduce the stoichiometric contributions of KCNQ2 and KCNQ3 subunits to currents generated by the coexpression. of KCNQ2 and...

DRIVER (Chinese)

64

Spatiotemporal characteristics of central otolith neurons

Chan, YS; Lai, CH; Jiang, B; Zhang, YK; Wang, H

DRIVER (Chinese)

66

Slow and incomplete inactivations of voltage-gated channels dominate encoding in synthetic neurons.

Lester, H A; Karschin, A; Hsu, H; Yang, X C; Huang, E; Labarca, C; Davidson, N; Figl, A; Ho, B

Electrically excitable channels were expressed in Chinese hamster ovary cells using a vaccinia virus vector system. In cells expressing rat brain IIA Na+ channels only, brief pulses (< 1 ms) of depolarizing current resulted in action potentials with a prolonged (0.5-3 s) depolarizing plateau; thi...

DRIVER (Chinese)

83

Modulation of brain Na+ channels by a G-protein-coupled pathway.

Scheuer, T; Ma, J Y; Catterall, W A; Li, M

Na+ channels in acutely dissociated rat hippocampal neurons and in Chinese hamster ovary (CHO) cells transfected with a cDNA encoding the alpha subunit of rat brain type IIA Na+ channel (CNaIIA-1 cells) are modulated by guanine nucleotide binding protein (G protein)-coupled pathways under conditions...

DRIVER (Chinese)

91

Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M-1 muscarinic acetylcholine receptors

Selyanko, AA; Hadley, JK; Wood, IC; Abogadie, FC; Jentsch, TJ; Brown, DA

1. KCNQ1-4 potassium channels were expressed in mammalian Chinese hamster ovary (CHO) cells stably transfected with M-1 muscarinic acetylcholine receptors and currents were recorded using the whole-cell perforated patch technique and cell-attached patch recording.2. Stimulation of M-1 receptors by 1...

DRIVER (Chinese)

92

INTERACTION OF THE ANTIEPILEPTIC DRUG LAMOTRIGINE WITH RECOMBINANT RAT-BRAIN TYPE IIA NA+ CHANNELS AND WITH NATIVE NA+ CHANNELS IN RAT HIPPOCAMPAL-NEURONS

XIE, XM; LANCASTER, B; PEAKMAN, T; GARTHWAITE, J

Actions of the new antiepileptic drug lamotrigine (LTG, Lamictal) were characterised using recombinant rat brain type IIA Na+ channels expressed in Chinese hamster ovary (CHO) cells and native Na+ channels in rat hippocampal pyramidal neurones, using whole-cell recording and intracellular recording ...

DRIVER (Chinese)

98

Fine mapping of the 9q31 Hirschsprung’s disease locus

Tang, S. C.; Sribudiani, Y.; Miao, P. X.; Vries, R. A.; Burzynski, G.; So, T. M.; Leon, Y. Y.; Yip, H. B.; Osinga, J.

Hirschsprung’s disease (HSCR) is a congenital disorder characterised by the absence of ganglia along variable lengths of the intestine. The RET gene is the major HSCR gene. Reduced penetrance of RET mutations and phenotypic variability suggest the involvement of additional modifying genes in the dis...

DRIVER (Chinese)

127

Association of GAD-65, but not of GAD-67, with the Golgi complex of transfected Chinese hamster ovary cells mediated by the N-terminal region.

Dirkx, R; Solimena, M; Muntzel, C; Aggujaro, D; Butler, M; De Camilli, P; Hayday, A

Glutamic acid decarboxylase (GAD) is the enzyme responsible for synthesis of the neurotransmitter gamma-aminobutyric acid in neurons and pancreatic beta cells. It is represented by two isoforms, GAD-65 and GAD-67, which are the products of two different genes and differ substantially only at their N...

DRIVER (Chinese)

133

Fu, Yu; 傅玉

DRIVER (Chinese)