Sample records for 辅酶Ⅰ (nad)

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Mutagen-induced resistance to mycophenolic acid in hamster cells can be associated with increased inosine 5'-phosphate dehydrogenase activity.

Huberman, E; Friedman, J; McKeown, C K

Cell variants resistant to the cytotoxic effect of mycophenolic acid, an inhibitor of IMP dehydrogenase (IMP:NAD+ oxidoreductase, EC, were selected by a one-step procedure from Chinese hamster V79 cells. The frequency of these variants was increased in a dose-dependent manner after treatme...

DRIVER (Chinese)


Isolation and characterization of a Chinese hamster ovary cell line deficient in fatty alcohol:NAD+ oxidoreductase activity.

Zoeller, R A; James, P F; Lee, J; Rizzo, W B

We have isolated a mutant Chinese hamster ovary cell line that is defective in long-chain fatty alcohol oxidation. The ability of the mutant cells to convert labeled hexadecanol to the corresponding fatty acid in vivo was reduced to 5% of the parent strain. Whole-cell homogenates from the mutant str...

DRIVER (Chinese)


Genotoxicity of 1,4-benzoquinone and 1,4-naphthoquinone in relation to effects on glutathione and NAD(P)H levels in V79 cells.

Ludewig, G; Glatt, H; Dogra, S

1,4-Benzoquinone is cytotoxic in V79 Chinese hamster cells and induces gene mutations and micronuclei. The cell-damaging effects of quinones are usually attributed to thiol depletion, oxidation of NAD(P)H, and redox-cycling involving the formation of semiquinone radicals and reactive oxygen species....

DRIVER (Chinese)


Alcohol Dehydrogenase Mutants of Chinese Hamster Somatic Cells Resistant to Allyl Alcohol

Thirion, Jean-Paul; Talbot, Brian

Alcohol dehydrogenase (alcohol: NAD oxidoreductase, E.C. mutants of Chinese hamster somatic cells were isolated as resistant to allyl alcohol (ALLR). The ALLR phenotypes of the mutant clones were reproducible with high fidelity and stable over long intervals of growth in the absence of the...

DRIVER (Chinese)


A physiological threshold for protection against menadione toxicity by human NAD(P)H : quinone oxidoreductase (NQO1) in Chinese hamster ovary (CHO) cells

Haan, L.H.J., de; Boerboom, A.M.J.F.; Rietjens, I.M.C.M.; Capelle, D., van; Ruijter, A.J.M., de; Jaiswal, A.K.

NAD(P)H:quinone oxidoreductase 1 (NQO1) has often been suggested to be involved in cancer prevention by means of detoxification of electrophilic quinones. In the present study, a series of Chinese hamster ovary (CHO) cell lines expressing various elevated levels of human NQO1 were generated by stabl...

DRIVER (Chinese)