Sample records for 分子生物学 (molecular biology)

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Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression

Medema, R.H.; Wubbolts, R.; Bos, J.L.

Insulin induces a rapid activation of p21ras in NIH 3T3 and Chinese hamster ovary cells that overexpress the insulin receptor. Previously, we suggested that p21ras may mediate insulin-induced gene expression. To test such a function of p21ras more directly, we studied the effect of different dominan...

DRIVER (Chinese)


The molecular biology and application of helicoverpa armigera nucleopolyhedrovirus

Sun, X.L.; Wang, H.L.; Deng, F.; Chen, Y.K.; Vlak, J.M.; Hong, Z.H.

DRIVER (Chinese)


TNFalpha-Polymorphismus bei Patienten mit Sepsis und Schilddrüsenkarzinomen

Rossbach, Christiane

Das Zytokin Tumornekrosefaktor a (TNFa) hat einen entscheidenden Anteil an der Entwicklung schwerer Komplikationen, wie septischer Schock und Multiorganversagen nach Entwicklung einer Sepsis. Eine Assoziation des TNF2-Allels mit einem erhöhten TNF a Spiegel und einer höheren Mortalitätsrate wurde i...

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On Microvascular Inflammation and Intestinal Leakage in Radiation Enteropathy

Röme, Andrada

Gastrointestinal tract damage is an insidious feature in patients undergoing radiotherapy. Microvascular inflammation, including leukocyte and platelet recruitment as well as epithelial barrier dysfunction, are considered to constitute key components in the pathophysiology of radiation-induced enter...

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Molecular cloning of the human excision repair gene ERCC-6.

Troelstra, C.; Odijk, H.; Wit, J. de; Westerveld, A.; Thompson, L.H.; Bootsma, D.; Hoeijmakers, J.H.J.

The UV-sensitive, nucleotide excision repair-deficient Chinese hamster mutant cell line UV61 was used to identify and clone a correcting human gene, ERCC-6. UV61, belonging to rodent complementation group 6, is only moderately UV sensitive in comparison with mutant lines in groups 1 to 5. It harbors...

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Molecular biology of cantharidin in cancer cells

Bauer, Rudolf; Rauh, Rolf; Boechzelt, Herbert; Kahl, Stefan; Kaina, Bernd; Efferth, Thomas

Herbal medicine is one of the forms of traditional medical practice. Traditional Chinese medicine (TCM) and traditional Vietnamese medicine (TVM) are well-known for their long-standing tradition of herbal medicine.

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Introduction and recovery of a selectable bacterial gene from the genome of mammalian cells

Breitman, ML; Tsui, L-C; Buchwald, M; Siminovitch, L

The simian virus 40 (SV40)-pBR322 recombinant, pSV2, carrying the origin of SV40 replication and the gpt gene of Escherichia coli, has been stably introduced into Chinese hamster ovary hprt- cells. All gpt-transformed cell lines were found to contain one or more insertions of pSV2 sequences exclusiv...

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Genetic diversity and identity of Chinese Loquat cultivars/accessions (Eriobotrya japonica) using mapped SSR markers from apple

He, Q.; Li, X.W.; Liang, G.L.; Weg, W.E., van de; Gao, Z.S.

Loquat (Eriobotrya japonica) is an underutilized fruit crop that originated in China and for which only a small number of molecular markers are available. This number can be increased by identifying apple SSRs that are transferable to loquat cultivars/accessions to provide new insight into the level...

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Galectin binding proteins in serum and bronchoalveolar lavage -in healthy and pathological conditions

Cederfur, Cecilia

Galectins are carbohydrate binding proteins, implicated in conditions of both inflammation and cancer. Connections between chronic inflammation and cancer are proposed by the increased remodelling and proliferation that occurs, leading to enhanced survival and proliferation of malignant cells. Since...

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Depletion of phosphatidylcholine affects ER morphology and protein traffic at the Golgi complex.

Testerink, N.; Sanden, Michiel Henrik Marie van der; Houweling, M.; Helms, J.B.; Vaandrager, A.B.

The mutant Chinese hamster ovary cell line MT58 contains a thermosensitive mutation in CTP:phosphocholine cytidylyltransferase, the regulatory enzyme in the CDP-choline pathway. As a result, MT58 cells have a 50% decrease in their phosphatidylcholine (PC) level within 24 h when cultured at the nonpe...

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Correlations in palmitoylation and multiple phosphorylation of rat bradykinin B-2 receptor in Chinese hamster ovary cells

Soskic, V; Nyakatura, E; Roos, M; Muller-Esterl, W; Godovac-Zimmermann, J

Rat bradykinin B-2 receptor from unstimulated Chinese hamster ovary cells transfected with the corresponding cDNA has been isolated, and subsequent mass spectrometric analysis of multiple phosphorylated species and of the palmitoylation attachment site is described. Bradykinin B-2 receptor was isola...

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Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study

Vaessen, SFC; Schaap, FG; Kuivenhoven, JA; Groen, AK; Hutten, BA; Boekholdt, SM; Hattori, H; Sandhu, MS; Bingham, SA

In mouse models, apolipoprotein A-V (apoA-V) exhibits triglyceride (TG)-lowering effects. We investigated the apoA-V/TG relationship and the association of apoA-V with coronary artery disease (CAD) risk by determining serum apoA-V levels and genotypes in a nested case-control (n = 1,034/2,031) study...

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