Sample records for 代谢产物 (metabolites)

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Stereoselective glucuronidation of carvedilol by Chinese liver microsomes*

Chen, Shu-qing; You, Lin-ya; Xie, Sheng-gu; Yu, Chun-na; Zeng, Su

Objective: To study the stereoselective glucuronidation of carvedilol (CARV) by three Chinese liver microsomes. Methods: The metabolites of CARV were identified by a hydrolysis reaction with β-glucuronidase and HPLC-MS/MS. The enzyme kinetics for CARV enantiomers glucuronidation was determined by a ...

DRIVER (Chinese)


Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells.

Niiyama, Kazuhito; Kojima, Hiroyuki; Takeuchi, Shinji; Katsura, Eiji; Kobayashi, Kunihiko

We tested 200 pesticides, including some of their isomers and metabolites, for agonism and antagonism to two human estrogen receptor (hER) subtypes, hERalpha and hERbeta, and a human androgen receptor (hAR) by highly sensitive transactivation assays using Chinese hamster ovary cells. The test compou...

DRIVER (Chinese)


Multiple activation pathways of benzene leading to products with varying genotoxic characteristics.

Ludewig, G; Glatt, H; Berchtold, G A; Padykula, R; Platt, K L; Klein, J; Oesch, F

Benzene and 13 potential metabolites were investigated for genotoxicity in Salmonella typhimurium and V79 Chinese hamster cells. In the presence of NADPH-fortified hepatic postmitochondrial fraction (S9 mix), benzene reverted his- S. typhimurium strains. The effect was strongest in strain TA1535. Am...

DRIVER (Chinese)


Identification of the major chemical constituents and their metabolites in rat plasma and various organs after oral administration of effective Erxian Decoction (EXD) fraction by liquid chromatography-mass spectrometry

Hu, YM; Wang, YT; Sze, SCW; Tsang, KW; Wong, HK; Liu, Q; Zhong, LD; Tong, Y

A simple and specific LC-DAD-ESI-MS/MS method has been developed and applied for the primary investigation of the chemical constituents absorbed or metabolized in vivo, after the rat oral administration of Erxian Decoction (EXD), a Chinese medicine prescription for menopausal syndromes. Through the ...

DRIVER (Chinese)


Identification of 7,12-dimethylbenz[a]anthracene metabolites that lead to mutagenesis in mammalian cells

Huberman, Eliezer; Yang, Shen K.; Chou, Ming W.

The mutagenicity of 7,12-dimethylbenz[a]-anthracene (DMBA) and 11 of its enzymatically derived metabolites was tested with Chinese hamster V79 cells for identification of mutagenic metabolites. The metabolites consisted of 7-hydroxymethyl-12-methylbenz[a]anthracene, 7-methyl-12-hydroxymethylbenz[a]a...

DRIVER (Chinese)


Both replication bypass fidelity and repair efficiency influence the yield of mutations per target dose in intact mammalian cells induced by benzo[a]pyrene-diol-epoxide and dibenzo[a,l]pyrene-diol-epoxide.

Lagerqvist, Anne; Hakansson, Daniel; Prochazka, Gabriela; Lundin, Cecilia; Dreij, Kristian; Segerback, Dan; Jernstrom, Bengt

Mutations induced by polycyclic aromatic hydrocarbons (PAH) are expected to be produced when error-prone DNA replication occurs across unrepaired DNA lesions formed by reactive PAH metabolites such as diol epoxides. The mutagenicity of the two PAH-diol epoxides (+)-anti-7,8-dihydroxy-9,10-epoxy-7,8,...

DRIVER (Chinese)


Amphotericin B selection of mutant Chinese hamster cells with defects in the receptor-mediated endocytosis of low density lipoprotein and cholesterol biosynthesis.

Kingsley, D; Krieger, M; Segal, M; Martin, J

This paper describes a rapid and efficient two-step procedure for the isolation of mutant cells with defects in receptor-mediated endocytosis. The procedure takes advantage of two fungal metabolites, compactin (ML236B), a potent inhibitor of cholesterol biosynthesis, and amphotericin B, a polyene an...

DRIVER (Chinese)


A potential antioxidant resource: Endophytic fungi from medicinal plants

Huang, WY; Cai, YZ; Xing, J; Corke, H; Sun, M

Medicinal plants and their endophytes are important resources for discovery of natural products. Several previous studies have found a positive correlation between total antioxidant capacity (TAC) and total phenolic content (TPC) of many medicinal plant extracts. However, no information is available...

DRIVER (Chinese)