Sample records for 信使核糖核酸 (messenger-rna)

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Translation of mRNA from Simian Virus 40-Infected Cells into Simian Virus 40 Capsid Protein by Cell-Free Extracts

Lodish, Harvey F.; Ozer, Harvey L.; Weinberg, Robert

Messenger RNA was isolated from simian virus 40 (SV40)-infected and mock-infected cells by chromatography on poly(U) sepharose. When added to cell-free extracts from Chinese hamster ovary cells or rabbit reticulocytes, RNA from the infected cells, but not from mock-infected cells, stimulated synthes...

DRIVER (Chinese)


Study of Gene-Targeted Mouse Models of Splicing Factor Gene Prpf31 Implicated in Human Autosomal Dominant Retinitis Pigmentosa (RP)

Bujakowska, K; Maubaret, C; Chakarova, CF; Tanimoto, N; Beck, SC; Fahl, E; Humphries, MM; Kenna, PF; Makarov, E; Makarova, O

PURPOSE. Pre-mRNA processing factor 31 (PRPF31) is a ubiquitous protein needed for the assembly of the pre-mRNA splicing machinery. It has been shown that mutations in this gene cause autosomal dominant retinitis pigmentosa 11 (RP11), which is characterized by rod-cell degeneration. Interestingly, m...

DRIVER (Chinese)


Prevalence and novelty of PRPF31 mutations in French autosomal dominant rod-cone dystrophy patients and a review of published reports

Audo, I; Bujakowska, K; Mohand-Said, S; Lancelot, ME; Moskova-Doumanova, V; Waseem, NH; Antonio, A; Sahel, JA; Bhattacharya, SS

Background: Rod-cone dystrophies are heterogeneous group of inherited retinal disorders both clinically and genetically characterized by photoreceptor degeneration. The mode of inheritance can be autosomal dominant, autosomal recessive or X-linked. The purpose of this study was to identify mutations...

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New amber mutation in a beta-thalassemic gene with nonmeasurable levels of mutant messenger RNA in vivo.

Kazazian, H H; Atweh, G F; Zhu, X X; Brickner, H E; Forget, B G

We have identified a beta-thalassemia gene that carries a novel nonsense mutation in a Chinese patient. This mutation, a G to T substitution at the first position of codon 43, changes the glutamic acid coding triplet (GAG) to a terminator codon (TAG). Based on oligonucleotide hybridization studies o...

DRIVER (Chinese)


Elongation of the Polyadenylate Segment of Messenger RNA in the Cytoplasm of Mammalian Cells

Diez, J.; Brawerman, G.

Chinese hamster and mouse sarcoma 180 ascites cells, treated with high levels of actinomycin D, still carry out limited poly(A) synthesis. The residual activity, which consists of poly(A) chain extension in the cytoplasm as well as in the nucleus, is essentially insensitive to cordycepin. Nuclear po...

DRIVER (Chinese)


Chinese hamster polyadenylated messenger ribonucleic acid: relationship to non-polyadenylated sequences and relative conservation during messenger ribonucleic acid processing.

Harpold, M M; Darnell, J E; Wilson, M C

We have further analyzed the metabolism of specific messenger ribonucleic acid (mRNA) sequences within the cytoplasmic and nuclear RNA of Chinese hamster ovary (CHO) cells by using a set of previously constructed complementary deoxyribonucleic acid (DNA) clones (Harpold et al., Cell 17:1025-1035, 19...

DRIVER (Chinese)