Sample records for 肝 (liver)
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84

α-1 Antitrypsin phenotypes by isoelectric focusing in a metropolitan southern Chinese population

Lam, K; Lee, S; Ko, K; Lawton, J; Lin, C

Aims/Background—α-1 Antitrypsin (α1AT) is an abundant protease inhibitor in human plasma. Its phenotypic variability has been reported to be associated with pulmonary emphysema and chronic liver diseases. However, α1AT deficiency is an uncommon condition in the Chinese population. The aim of this st...

DRIVER (Chinese)

85

gamma-Aminobutyric acid transaminase (GABAT) polymorphism among ethnic groups in Singapore--with report of a new allele.

Bhattacharyya, S P; Wee, K P; Saha, N

gamma-Aminobutyric acid transaminase (GABAT, E.C.2.6.I.19) was phenotyped by starch-gel electrophoresis in post-mortem liver samples from 650 unrelated subjects of either sex, comprising 289 Chinese, 177 Indians, 140 Malays, and 44 from other racial groups from Southeast Asia. The estimated gene fre...

DRIVER (Chinese)

86

Tuberculous pseudotumour of the liver developing during antituberculous chemotherapy.

Nolan, R L; Forward, K R; Campbell, R O; Tong, A Y

A 29-year-old Chinese woman presented with a liver mass 2 months after initiation of chemotherapy for disseminated tuberculosis. A percutaneous liver biopsy revealed tuberculous pseudotumour. Although acid-fast bacilli were seen in the biopsy specimen, no organism could be cultured. No changes were ...

DRIVER (Chinese)

89

TNFalpha-Polymorphismus bei Patienten mit Sepsis und Schilddrüsenkarzinomen

Rossbach, Christiane

Das Zytokin Tumornekrosefaktor a (TNFa) hat einen entscheidenden Anteil an der Entwicklung schwerer Komplikationen, wie septischer Schock und Multiorganversagen nach Entwicklung einer Sepsis. Eine Assoziation des TNF2-Allels mit einem erhöhten TNF a Spiegel und einer höheren Mortalitätsrate wurde i...

DRIVER (Chinese)

90

Studies on the genetic effects of phthalic acid esters on cells in culture.

Phillips, B J; Gangolli, S D; Anderson, D

Mono(2-ethylhexyl) phthalate (MEHP) induced chromosome aberrations in cells of two culture lines, one derived from Chinese hamster ovary cells (CHO) and the other from rat liver cells (RL4). In CHO cells, the clastogenicity of MEHP was unaffected by the presence of an exogenous metabolic activation ...

DRIVER (Chinese)

91

Stereoselective glucuronidation of carvedilol by Chinese liver microsomes*

Chen, Shu-qing; You, Lin-ya; Xie, Sheng-gu; Yu, Chun-na; Zeng, Su

Objective: To study the stereoselective glucuronidation of carvedilol (CARV) by three Chinese liver microsomes. Methods: The metabolites of CARV were identified by a hydrolysis reaction with β-glucuronidase and HPLC-MS/MS. The enzyme kinetics for CARV enantiomers glucuronidation was determined by a ...

DRIVER (Chinese)

96

Ribosomal protein S14 is altered by two-step emetine resistance mutations in Chinese hamster cells.

Roufa, D J; Madjar, J J; McGill, S; Frahm, M

Four two-dimensional polyacrylamide gel electrophoresis systems were used to identify 78 Chinese hamster cell ribosomal proteins by the uniform nomenclature based on rat liver ribosomal proteins. The 40S ribosomal subunit protein affected by Chinese hamster ovary (CHO) cell one-step emetine resistan...

DRIVER (Chinese)

101

On Microvascular Inflammation and Intestinal Leakage in Radiation Enteropathy

Röme, Andrada

Gastrointestinal tract damage is an insidious feature in patients undergoing radiotherapy. Microvascular inflammation, including leukocyte and platelet recruitment as well as epithelial barrier dysfunction, are considered to constitute key components in the pathophysiology of radiation-induced enter...

DRIVER (Chinese)

102

Mammalian Peptide Chain Termination, II. Codon Specificity and GTPase Activity of Release Factor

Beaudet, Arthur L.; Caskey, C. T.

In vitro peptide chain termination with release factor preparations from rabbit reticulocytes, guinea pig liver, or Chinese hamster liver is directed with UAAA, UAGA, or UGAA, suggesting that UAA, UAG, and UGA are terminator condons for mammalian cells. Purified release factor from rabbit reticulocy...

DRIVER (Chinese)

104

Liver in haemoglobin H disease

Keng, Chew Beng; Khoo, Tan Kheng

There have been no published reports on the liver of patients with haemoglobin H disease. In 11 Chinese patients studied (six male and five female) with haemoglobin H disease hepatic function and histology were studied. Liver function was normal in all cases; however, the gamma globulin level was ra...

DRIVER (Chinese)

106

Liver cell-mediated mutagenesis of mammalian cells by liver carcinogens.

Langenbach, R; Huberman, E; Freed, H J

A cell-mediated mutagenesis assay using primary cultures of rat liver cells and V79 Chinese hamster cells has been developed. Liver carcinogens and their structural analogues were studied. Mutations in the V79 cells were characterized by resistance to ouabain. Cocultivation of the liver cells and V7...

DRIVER (Chinese)

112

Histologic changes of the iris in the development of angle closure in Chinese eyes

He, MG; Lu, Y; Liu, X; Ye, TC; Foster, PJ

Purpose: To identify the histologic characteristics of the iris in primary angle closure.Methods: Iris specimens were obtained by surgical iridectomy in a series of patients in Zhongshan Ophthalmic Center with newly diagnosed acute angle Closure (AAC, 12 eyes), fellow eyes of AAC subjects (FAAC, 14 ...

DRIVER (Chinese)

114

Hemoglobin synthesis in somatic cell hybrids: coexpression of mouse with human or chinese hamster globin genes in interspecific somatic cell hybrids of mouse erythroleukemia cells.

Nienhuis; Deisseroth, A; Anderson, W F; Barker, J

Somatic cell hybrids were derived by fusion of mouse erythroleukemia cells with fractionated human marrow enriched in erythroblasts, or with chinese hamster fetal liver erythroid cells. Such interspecific hybrid cells, when isolated in suspension culture, had retained nearly all the mouse chromosome...

DRIVER (Chinese)

115

HLA class II alleles in Chinese patients with hepatocellular carcinoma

Donaldson, PT; Ho, S; Williams, R; Johnson, PJ

BACKGROUND/AIMS: Recent reports of an association between human leucocyte antigens (HLA) and persistence of hepatitis B virus infection, and the familial clustering of hepatocellular carcinoma raise the question of genetic susceptibility. Previous studies have been limited to serological phenotyping...

DRIVER (Chinese)

117

Duck hepatitis B virus DNA in liver and serum of Chinese ducks: integration of viral DNA in a hepatocellular carcinoma.

Imazeki, F; Yokosuka, O; Zhou, Y Z; Omata, M; Okuda, K

The presence of duck hepatitis B virus (DHBV) DNA in liver and serum and its state (integrated vs. free) were studied in 23 ducks from Chi-tung county in China by spot hybridization and Southern blot hybridization, respectively. In 16 of 23 (70%), DHBV DNA was detected in serum and/or in liver tissu...

DRIVER (Chinese)

121

Bone turnover markers and prediction of bone loss in elderly women

Lenora, Janaka

Around 70,000 osteoporosis-related fractures occur in Sweden annually and approximately half of the women in western world will sustain a fragility fracture after the age of 50 years. Fracture preventive efforts require the identification of individuals who are at high risk. Biochemical markers of b...

DRIVER (Chinese)

122

Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men.

Lu, R B; Wang, S P; Mai, X L; Thomasson, H R; Yin, S J; Crabb, D W; Edenberg, H J; Jerome, R E; Lin, Y T; Li, T K

The liver enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), which are responsible for the oxidative metabolism of ethanol, are polymorphic in humans. An allele encoding an inactive form of the mitochondrial ALDH2 is known to reduce the likelihood of alcoholism in Japanese. We hy...

DRIVER (Chinese)

123

Activation of aromatic amines to mutagens by bovine bladder and liver cells

Sieg, Marianne; Oglesby, Linda; MacNair, Pat; Hix-Baker, Cathy; Snow, Linda; Langenbach, Robert

A bovine bladder cell-mediated mutagenesis system using Chinese hamster V79 cells and Salmonella typhimurium as target organisms was developed to investigate the capacity of the bladder urothelium to activate chemical carcinogens. Bovine bladder epithelial cells can activate the aromatic amines AF a...

DRIVER (Chinese)

124

A survey of Chinese herbal ingredients with liver protection activities

Lien, Linda Lin-min; Wang, Rubin; Wang, Dali; Kong, John; Lien, Eric Jung-chi

A literature survey was conducted on herbs, their preparations and ingredients with reported liver protection activities, in which a total of 274 different species and hundreds of active ingredients have been examined. These ingredients can be roughly classified into two categories according to thei...

DRIVER (Chinese)

126

A case-control study on the relationship between HDL2b and non-alcoholic fatty liver disease in Chinese type 2 diabetic patients

Ma, Ya-Hong; Zhao, Lei; Xian, Xun-De; Yang, Dorothy; Huang, Wei; Wang, Yu-Hui; Mueller, Odilo; Chang, Elaine; Konigshofer, Yves

Background: It has been shown that low concentrations of high-density lipoprotein cholesterol (HDL-C) are associated with non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). HDL2b, a major subfraction of high-density lipoprotein (HDL), is more significantly co...

DRIVER (Chinese)

127

Zhao, M.; zhang, N.X.; Du, Z.Y.; Laissue, J.A.; Zimmermann, Astrid

DRIVER (Chinese)