Sample records for 不稳定性 (instability)

Sample records 1 - 17 shown.


The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells

Zhou, Zi-Q.; Liu, Nan; Tucker, James D.; Lamerdin, Jane E.; Walter, Christi A.; Thompson, Larry H.; Albala, Joanna S.

The Chinese hamster ovary (CHO) mutant UV40 cell line is hypersensitive to UV and ionizing radiation, simple alkylating agents, and DNA cross-linking agents. The mutant cells also have a high level of spontaneous chromosomal aberrations and 3-fold elevated sister chromatid exchange. We cloned and se...

DRIVER (Chinese)


Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with Hereditary non-polyposis colorectal cancer

Sheng, JQ; Chan, TL; Chan, YW; Huang, JS; Chen, JG; Zhang, MZ; Guo, XL; Mu, H; Chan, ASY; Li, SR; Yuen, ST; Leung, SY

DRIVER (Chinese)


Genomic Instability in Wheat Induced by Chromosome 6b(s) of Triticum Speltoides

Kota, R. S.; Dvorak, J.

A massive restructuring of chromosomes was observed during the production of a substitution of chromosome 6B(s) from Triticum speltoides (Tausch) Gren. ex Richter for chromosome 6B of Chinese Spring wheat (Triticum aestivum L.). Deletions, translocations, ring chromosomes, dicentric chromosomes and ...

DRIVER (Chinese)


Frequent microsatellite instability and mismatch repair gene mutations in young Chinese patients with colorectal cancer

Chan, TL; Yuen, ST; Chung, LP; Ho, JWC; Kwan, KYM; Chan, ASY; Ho, JCY; Leung, SY; Wyllie, AH

DRIVER (Chinese)


Chromosome instability associated with human alphoid DNA transfected into the Chinese hamster genome.

Heartlein, M W; Latt, S A; Knoll, J H

Repetitive DNA sequences have been implicated in the mediation of DNA rearrangement in mammalian cells. We have tested this hypothesis by using a dihydrofolate reductase (DHFR) expression vector into which candidate sequences were inserted. DHFR- Chinese hamster ovary (CHO) cells were transfected wi...

DRIVER (Chinese)


Amplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaks

Trask, Barbara J.; Singer, Michael J.; Friedman, Cynthia L.; Mesner, Larry D.; Hamlin, Joyce L.

DNA sequence amplification is one of the most frequent manifestations of genomic instability in human tumors. We have shown previously that amplification of the dihydrofolate reductase (DHFR) gene in Chinese hamster cells is initiated by chromosome breaks, followed by bridge-breakage-fusion cycles t...

DRIVER (Chinese)


A mismatch recognition defect in colon carcinoma confers DNA microsatellite instability and a mutator phenotype.

MacGeoch, C; Aquilina, G; Branch, P; Hess, P; Casciano, I; Karran, P; Bignami, M

We have analyzed spontaneous mutations in the adenine phosphoribosyltransferase gene of Chinese hamster clone B cells that exhibit a mutator phenotype because of defective mismatch binding. The mutator phenotype conferred increases in a limited number of mutational classes. The rates of transitions ...

DRIVER (Chinese)


A common genetic factor for Parkinson disease in ethnic Chinese population in Taiwan

Fung, HC; Chen, CM; Hardy, J; Singleton, AB; Wu, YR

Background: Parkinson's disease (PD) is the most common neurodegenerative movement disorder, characterized clinically by resting tremor, bradykinesia, postural instability and rigidity. The prevalence of PD is approximately 2% of the population over 65 years of age and 1.7 million PD patients ( age ...

DRIVER (Chinese)