Sample records for 肝素 (heparin)

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Poly(L-lysine) has different membrane transport and drug-carrier properties when complexed with heparin.

Shen, W C; Ryser, H J

Methotrexate (MTX) conjugated to a Mr 3000 poly(L-Lys) markedly inhibits the growth of Pro-3 MtxRII5-3 Chinese hamster ovarian cells, a mutant line known to be drug resistant because of defective MTX transport. In these cells, membrane transport of [3H]MTX-poly(Lys) is sharply decreased by addition ...

DRIVER (Chinese)


Heparin-dependent binding and autophosphorylation of epidermal growth factor (EGF) receptor by heparin-binding EGF-like growth factor but not by EGF.

Aviezer, D; Yayon, A

Heparin-binding EGF-like growth factor (HB-EGF) is a recently identified member of the EGF family of growth factors and a potent mitogen for smooth muscle cells and fibroblasts. Chinese hamster ovary (CHO) cells genetically engineered to express the human EGF receptor bind with high affinity both EG...

DRIVER (Chinese)


Heparin therapy in the Chinese--lower doses are required

Yu, CM; Chan, TY; Tsoi, WC; Sanderson, JE

Warfarin requirements are lower in the Chinese, but it is not known if this applies to heparin. We investigated the optimal dose for heparin therapy in Chinese patients, and to assess relationship between i.v. heparin dosage and anticoagulation efficacy. One hundred Chinese patients requiring intrav...

DRIVER (Chinese)


Deep vein thrombosis and pulmonary embolism in the Chinese population

Nandi, PL; Li, WS; Leung, R; Chan, J; Chan, HT

Deep vein thrombosis and pulmonary embolism is a well-recognised major health problem in the West. There is a deep-rooted belief among clinicians that deep vein thrombosis is rare in Asians, particularly in the Chinese population. However, it appears that the incidence of venous thrombosis and pulmo...

DRIVER (Chinese)


Chinese hamster ovary cell adhesion to human platelet thrombospondin is dependent on cell surface heparan sulfate proteoglycan.

Mosher, D F; Kaesberg, P R; Esko, J D; Ershler, W B

Thrombospondin is a 420-kD platelet alpha-granule glycoprotein that binds specifically to heparin. We examined adhesion to thrombospondin of CHO K1 cells and three mutant CHO lines with varying deficiencies in glycosaminoglycan (GAG) synthesis. In an experiment in which the parent line (K1) had 78% ...

DRIVER (Chinese)


Aspirin or heparin in acute stroke

Pereira, AC; Brown, MM

Acute stroke treatment using aspirin and/or heparin was studied in the International Stroke Trial (IST) and Chinese Acute Stroke Trial (CAST) which randomised over 40,000 patients altogether. Combining the results demonstrated that aspirin (150-300 mg) given within 48 h of the onset of stroke produc...

DRIVER (Chinese)