Sample records for 遗传变异性 (genetic variability)

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Reduced RET expression in gut tissue of individuals carrying risk alleles of Hirschsprung's disease

Miao, X; Leon, TY-Y; Ngan, ES-W; So, M-T; Yuan, Z-W; Lui, VC-H; Chen, Y; Wong, KK-Y; Tam, PK-H; Garcia-Barceló, M

Receptor tyrosine kinase (RET) single nucleotide polymorphisms (SNPs) are associated with the Hirschsprung's disease (HSCR). We investigated whether the amount of RET expressed in the ganglionic gut of human was dependent on the genotype of three regulatory SNPs (-5G>A rs10900296 and -1A>C rs1090029...

DRIVER (Chinese)


Recent human evolution has shaped geographical differences in susceptibility to disease

Marigorta, U.M.; Lao, O.; Casals, F.; Calafell, F.; Morcillo-Suárez, C.; Faria, R.; Bosch, E.; Serra, F.; Bertranpetit, J.

Background: Searching for associations between genetic variants and complex diseases has been a very active area of research for over two decades. More than 51,000 potential associations have been studied and published, a figure that keeps increasing, especially with the recent explosion of array-ba...

DRIVER (Chinese)