Sample records for 半乳糖 (galactose)
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15

Mutant hamster cells exhibiting a pleiotropic effect on carbohydrate metabolism.

Sun, N C; Chu, E H; Chang, C C

Sixty-seven galactose negative (Gal minus) clones were established from survivors after treatment of Chinese hamster lung (V79) cells with 5-bromodeoxyuridine and black light. The mutational origin of these clonal isolates was inferred on the basis of the previously demonstrated mutagenic action of ...

DRIVER (Chinese)

16

Molecular cloning of two Arabidopsis UDP-galactose transporters by complementation of a deficient Chinese hamster ovary cell line

Bakker, H.; Routier, F.; Oelmann, S.; Jordi, W.J.R.M.; Lommen, A.; Gerardy-Schahn, R.; Bosch, H.J.

Nucleotide-sugar transporters (NSTs) form a family of structurally related transmembrane proteins that transport nucleotide-sugars from the cytoplasm to the endoplasmic reticulum and Golgi lumen. In these organelles, activated sugars are substrates for various glycosyltransferases involved in oligo-...

DRIVER (Chinese)

17

Metabolic control of recombinant protein N-glycan processing in NS0 and CHO cells

Baker, KN; Rendall, MH; Hills, AE; Hoare, M; Freedman, RB; James, DC

Chinese hamster ovary and murine myeloma NS0 cells are currently favored host cell types for the production of therapeutic recombinant proteins. In this study, we compared N-glycan processing in GS-NS0 and GS-CHO cells producing the same model recombinant glycoprotein, tissue inhibitor of metallopro...

DRIVER (Chinese)

18

Isolation of a Clone of Chinese Hamster Ovary Cells Deficient in Plant Lectin-Binding Sites

Gottlieb, Charlene; Kornfeld, Stuart; Skinner, Sister Ann Marie

Ricin, a galactose-binding lectin with potent cytotoxic activity, was used to select a clone of Chinese hamster ovary cells with altered plant lectin-binding properties. The clone (15B) is 80-fold less sensitive to the toxic action of ricin than the parent line. In the absence of ricin, it grows bot...

DRIVER (Chinese)

19

Internalization of ricin in Chinese hamster ovary cells.

Ray, B; Wu, H C

Internalization of ricin into Chinese hamster ovary cells has been investigated. Combined treatment with galactose and pronase at 0 degrees C resulted in a complete release of surface-bound [125I]ricin into the media. Galactose-pronase-resistant cell-bound [125I]ricin represents internalized ricin m...

DRIVER (Chinese)

30

Cotransfer of thymidine kinase and galactokinase genes by chromosome-mediated gene transfer.

McBride, O W; Ruddle, F H; Burch, J W

The Chinese hamster genes for thymidine kinase (ATP:thymidine 5'-phosphotransferase, EC 2.7.1.75) and galactokinase (ATP:D-galactose 1-phosphotransferase, EC 2.7.1.6) have been cotransferred to mouse cells by chromosome-mediated gene transfer. Hamster metaphase chromosomes were incubated with mouse ...

DRIVER (Chinese)

31

Chromosome Assignment of the Human Gene for Galactose-1-phosphate Uridyltransferase*

Sun, N. C.; Chu, E. H. Y.; Chang, C. C.

Somatic cell hybrids formed between galactose-negative mutant Chinese hamster cells and human lymphocytes were selected in galactose medium and analyzed for the concurrent presence of specific human chromosome(s) and human galactose-1-phosphate uridyltransferase. In one of the hybrid clones only a s...

DRIVER (Chinese)

32

Characterization of cell surface carbohydrate receptors for Entamoeba histolytica adherence lectin.

Petri, W A; Ravdin, J I; Murphy, C F; Stanley, P

Binding and cytolysis of Chinese hamster ovary (CHO) cells by Entamoeba histolytica trophozoites is inhibitable by galactose (Gal) or N-acetyl-D-galactosamine (GalNAc). To better define the carbohydrate receptor for E. histolytica, we compared the binding and cytolytic target properties of 10 CHO gl...

DRIVER (Chinese)