Sample records for thio compounds
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Sample records 1 - 1 shown.



1

Síntese do monastrol e novos compostos de Biginelli promovida por In(OTf)3/ Synthesis of monastrol and of new Biginelli compounds promoted by In(OTf)3

Godoi, Marla N.; Costenaro, Hellen S.; Kramer, Eliane; Machado, Paola S.; D'Oca, Marcelo G. Montes; Russowsky, Dennis
2005-12-01

Resumo em inglês In this paper, we describe a practical route for the synthesis of Biginelli compounds using In(OTf)3. To study the generality of this catalyst, several examples using aromatic aldehydes, 1,3-dicarbonyl compounds, urea, and thiourea were investigated. The present procedure provides an efficient modification of the classical Biginelli reaction, namely short reaction times and simple work-up, that not only preserves the simplicity of the original protocol but also produces e (mais) xcellent yields of 3,4-dihydropyridin-2(1H)-ones. Thiourea was used with similar success to provide the corresponding 3,4-dihydropyridin-2(1H)-thiones. In this case, the (+/-)-monastrol, antimitotic agent, was obtained in 92% yield and new thio analogues were synthesized.

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