Sample records for hydrazides
from WorldWideScience.org

Sample records 1 - 3 shown.



1

Validação lateral em relações quantitativas entre estrutura e atividade farmacológica, QSAR/ Comparative QSAR of antimicrobial hydrazides

Montanari, Maria Luiza C.; Montanari, Carlos A.; Gaudio, Anderson C.
2002-05-01

Resumo em inglês The comparative QSAR is a tool for validating any statistical model that seems to be reasonable in describing an interaction between a bioactive new chemical entity, BIONCE, and the biological system. In order to deeper the understanding of the relationships and the meaning of parameters within the model it is necessary some kind of lateral validation. This validation can be accomplished by chemical procedures using physicochemical organic reactions and by means of biolog (mais) ical systems. In this paper we review some of such comparisons and also present a lateral validation between the same set of antimicrobial hydrazides acting against Saccharomyces cerevisiae yeast and Escherichia coli bacterium cells. QSARs are presented to shed light in this important way of stating that the QSAR model is not the endpoint, but the beginning.

Scientific Electronic Library Online (Portuguese)

2

Síntese e determinação da atividade antimicrobiana de derivados 5-nitro-2-tiofilidênicos frente a Staphylococcus aureus multi-resistente/ Synthesis and determination of antimicrobial activity of 5-nitro-2-thiophylidene derivatives against MRSA

Masunari, Andrea; Tavares, Leoberto Costa
2006-09-01

Resumo em português O elevado nível de resistência que cepas de Staphylococcus aureus vêm apresentando aos antibióticos atualmente disponíveis caracteriza-se como grave problema em âmbito mundial e com consequências que beiram à fatalidade. Com a atenção voltada para este fenômeno, quatorze derivados 5-nitro-2-tiofilidênicos foram sintetizados e testados quanto à atividade antimicrobiana frente a cepas padrão (ATCC 25923) e multi-resistente (3SP/R33) de Staphylococcus aureus. T (mais) odos os compostos testados apresentaram excelente atividade bacteriostática e, alguns entre eles, atividade bactericida. A 5-nitro-2-tiofilideno-4-acetilbenzidrazida se mostrou como o composto mais ativo com concentração inibitória equivalente a 0,14 mg/mL. A partir dos resultados obtidos evidenciou-se o forte potencial de derivados 5-nitro-2-tiofilidênicos como possível alternativa para o desenvolvimento de novos fármacos com atividade antimicrobiana. Resumo em inglês Infection diseases caused by methicillin-resistant Staphylococcus aureus have been an increasing problem worldwide presenting significant morbidity and mortality rates. Thus, fourteen benzoic acid [(5-nitro-thiophen-2-yl)-methylene]-hydrazides were designed, synthesized and tested against standard (ATCC 25923) and multidrug-resistant strains of Staphylococcus aureus. All compounds exhibited significant bacteriostatic activity and, in such cases, also bactericidal activity (mais) , especially the p-COCH3 derivative with MIC = 0.14 mg/mL. The results have demonstrated the potential of synthesized compounds as alternative to the development of selective antimicrobial agents.

Scientific Electronic Library Online (Portuguese)

3

Sistemas transportadores de drogas/ Drug delivery systems

Montanari, Maria Luiza C.; Montanari, Carlos Alberto; Piló-Veloso, Dorila; Beezer, A. E.; Mitchell, J. C.
1998-07-01

Resumo em inglês Drug delivery system controls the distribution of drugs for optimal therapeutic efficacy. The complex of higly active drugs with macromolecular carriers seems to offer a promising way to optimize their delivery. Dendrimers can be used as drug delivery system and this paper addresses the effectivenes of the approach. The host-guest system improves the solubility of hydrazides and mesoionic 1,3,4-thiadiazolium-2-aminide compounds.

Scientific Electronic Library Online (Portuguese)