Sample records for hematin
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Sample records 1 - 2 shown.



1

Estudos sôbre a anemia produzida em cães por benzoato de estradiol

Cruz, W. O.; Mello, R. Pimenta de; Silva, E. M. da
1944-08-01

Resumo em português A anemia que se processa em caes quando se administra grandes doses de benzoato de estradiol, nao parece ser produzida por processes conhecidos de destrui?ao intra-organica. Esta substantia paraliza os fenomenos de rege¬nerate hematica, parece interferir por processo desconhecido na fisiologia sanguinea, produz graves lesoes na rede circulatoria que irriga a mucosa do intestino, principalmente jejuno, ocasipnando nesse orgao «extravasamento variavel de sangue, fator seguramente coadjuvante na formação da anemia. Resumo em inglês The characteristic findings in the pathological picture presented by 60 dogs when administered large doses of estradiol benzoate subcutaneously in an oil vehicle are: thrombocytopenia, aplastic anemia, which follows a brief latent period, intestinal tract haemorrhages, haemorrhagic lesions occurring principally in the mucosa of the jejunum, followed by prostration and death generally within 1 to 3 weeks. Irregular findings are leucocytosis, purpuric skin lesions, visceral (mais) haemorrhages and pyoid bone marrow. The total circulating hemoglobin was determined in 9 dogs before and after the anemia was established, thus verifying the total hemoglobin loss. The blood loss through intestinal haemorrhages during the observation period was determined by benzidine test. The quantity of hemoglobin recovered from the feces in the form of hematin varied between 30 and 70% of the total hemoglobin which disappeared from the circulation. In order to ascertain the degree of intra-organic blood destruction the bilirubin eliminated in the urine of dogs with gall-bladder renal type of fis¬tula was determined daily and these values compared with those obtained for normal animals. The blood destruction as measured by this method was practically nil. An attempt was made to determine whether the presence of large quan¬tities of blood in the intestine might exert a paralyzing effect on the regene¬ration of hemoglobin in dogs rendered anemic through haemorrhage. Ne¬gative results were obtained. Estradiol benzoate administered to dogs during the period of hematic regeneration which occurs in the recovery stage of ane-mia produced by acetyl-phenyl hydrazine demonstrated that the estradiol in¬terferes but little when the regenerative processes have already begun. Repeated transfusions given during the stage of acute anemia practi¬cally do not affect the period of survival. The authors conclude that the main action of estradiol benzoate on the blood physiology of dogs is still obscure. The anemia is not produced by the intra-organic destruction of hemoglobin by known processes and doubtless the blood loss through the intestinal haemarrhages constitutes an important ac¬cessory factor in the mechanism of bringing out this anemia.

Scientific Electronic Library Online (Portuguese)

2

Porfiria aguda intermitente: relato de caso e revisão da literatura/ Acute intermittent porphyria: case report and review of the literature

Lopes, Daniela von Ah; Valle, Marcelo Araújo do; Taguti, Jéfferson; Taguti, Regina Celli Thomé Castro; Betônico, Gustavo Navarro; Medeiros, Fabiana Clemente
2008-12-01

Resumo em português Porfiria aguda intermitente é patologia incomum, com conseqüências potencialmente graves se não reconhecida precocemente. Dentre as possíveis causas de indução de crises de porfiria, a redução da ingestão calórica é descrita na literatura. Relatamos um caso de porfiria aguda intermitente no pós-operatório tardio de gastroplastia indicada para tratamento da obesidade, revisando aspectos do diagnóstico e tratamento da patologia na unidade de terapia intensiva (mais) . Paciente feminina, 31 anos, com história de gastroplastia há 3 semanas admitida na unidade de terapia intensiva com rebaixamento do nível de consciência e desconforto respiratório. Evoluiu com agitação psicomotora, confusão mental, dor abdominal e tetraparesia proximal. Na investigação diagnóstica foi encontrado hiponatremia grave (92 mEq/L), hipomagnesemia, hipofosfatemia e hipocalcemia, urina turva, sem hematúria. Aventou-se hipótese de porfiria aguda, realizado dosagem do ácido delta-aminolevulínico e porfobilinogênio na urina de 24h, com elevação de ambos. Iniciado tratamento com dieta rica em carboidratos, sem utilizar hematina ou arginato de heme, devido à dificuldades no fornecimento destas medicações. Evoluiu com melhora clínica gradativa e recuperação completa da força muscular após 8 meses. A porfiria aguda intermitente possui sinais e sintomas comuns a muitas patologias clínicas e neuropsiquiátricas dificultando o diagnóstico, em especial quando estes se manifestam isoladamente. Assim, deve-se incluir a porfiria aguda intermitente no diagnóstico diferencial de distúrbios neurológicos, psiquiátricos e gastroenterológicos em crises, no qual todos os demais exames estejam normais. Atenção deve ser dada a pacientes submetidos à cirurgias, em especial cirurgia bariátrica que, além do estresse cirúrgico, limita substancialmente a ingesta calórica podendo desencadear crises. Não há descrito na literatura, até o momento, nenhum caso de porfiria aguda intermitente no pós-operatório de cirurgia bariátrica. Resumo em inglês Acute intermittent porphyria is an unusual pathology with potentially severe consequences when not early detected. Among the possible causes of porphyric crises decrease of caloric intake has been described. A case of acute intermittent porphyria in the late postoperative period of a bariatric surgery performed for treatment of obesity is reported. A review of the diagnostic aspects and management of this pathology in the intensive care unit follows. A 31 year old woman w (mais) as admitted in the intensive care unit three weeks after a bariatric surgery, with decreased level of consciousness and respiratory distress. The patient evolved with psychomotor agitation, mental confusion, abdominal pain and proximal tetraparesis. Diagnosis investigation disclosed severe hyponatremia (92mEq/L), hypomagnesemia, hypophosfatemia and hypocalcemia and cloudy urine without hematuria. Acute porphyria was suspected and the urine test detected high delta amino-levulinic acid and porphobilinogen. Treatment consisted of a correction of electrolyte disturbances and high carbohydrate intake. Hematin and heme arginate were not used, due to the difficulty to acquire the medication. After 8 months the patient progressed with full recovery of muscle strength and a clinical improvement. Acute intermittent porphyria has signs and symptoms common to several clinical, neurological, psychiatric and gastroenterological pathologies, which complicate diagnosis. Therefore, acute intermittent porphyria should be included in the differential diagnosis of neurological, psychiatric and gastroenterological alterations when results of all other exams are normal. Attention must be given to patients undergoing surgery mainly bariatric that, in addition to procedure stress, substantially limit the total caloric intake, potentially triggering crises. Review of literature did not disclose any report of acute intermittent porphyria crisis induced by bariatric surgery.

Scientific Electronic Library Online (Portuguese)