Sample records for decanoic acid

Sample records 1 - 1 shown.


Potencial de biocatálise enantiosseletiva de lipases microbianas/ Potential of enantioselective biocatalysis by microbial lipases

Carvalho, Patrícia de O.; Calafatti, Silvana Ap.; Marassi, Maurício; Silva, Daniela M. da; Contesini, Fabiano J.; Bizaco, Renato; Macedo, Gabriela Alves

Resumo em inglês Microbial lipases have a great potential for commercial applications due to their stability, selectivity and broad substrate specificity because many non-natural acids, alcohols or amines can be used as the substrate. Three microbial lipases isolated from Brazilian soil samples (Aspergillus niger; Geotrichum candidum; Penicillium solitum) were compared in terms of their stability and as biocatalysts in the enantioselective esterification using racemic substrates in organi (mais) c medium. The lipase from Aspergillus niger showed the highest activity (18.2 U/mL) and was highly thermostable, retaining 90% and 60% activity at 50 ºC and 60 ºC after 1 hour, respectively. In organic medium, this lipase provided the best results in terms of enantiomeric excess of the (S)-active acid (ee = 6.1%) and conversion value (c = 20%) in the esterification of (R,S)-ibuprofen with 1-propanol in isooctane. The esterification reaction of the racemic mixture of (R,S)-2-octanol with decanoic acid proceeded with high enantioselectivity when lipase from Aspergillus niger (E = 13.2) and commercial lipase from Candida antarctica (E = 20) were employed.

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