Sample records for chloranil
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Sample records 1 - 1 shown.



1

Determinação espectrofotométrica de citrato de sildenafil em formulações farmacêuticas/ Spectrophotometric determination of sildenafil citrate in pharmaceutical formulations

Weinert, Patrícia Los; Pezza, Leonardo; Pezza, Helena Redigolo
2008-01-01

Resumo em inglês This paper describes a simple and rapid spectrophotometric method for quantitative determination of sildenafil citrate based on its reaction with p-chloranil accelerated by hydrogen peroxide, producing a stable purple compound (λmax= 535 nm). In the absence of peroxide this reaction is very slow. The experimental conditions were optimized by using response surface methodologies. Beer's law is obeyed in a concentration range of 8.52 x 10-5 - 1.70 x 10-3 mol L-1 (r = 0 (mais) .999). The detection limit was 1.96 x 10-5 mol L-1. The method was successfully applied for the determination of sildenafil citrate in medicines with good accuracy and precision.

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