Sample records for ARN-MESSAGER (messenger-rna)

Sample records 1 - 13 shown.



Anderson, W. French

Two in vitro protein-synthesizing systems derived from E. coli have been utilized to demonstrate that the concentration of a tRNA species can regulate the rate of translation of a messenger RNA. (a) The rate of poly-U-directed C14-phenylalanine incorporation into protein is stimulated by concentrati...

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Prevalence and novelty of PRPF31 mutations in French autosomal dominant rod-cone dystrophy patients and a review of published reports

Audo, I; Bujakowska, K; Mohand-Said, S; Lancelot, ME; Moskova-Doumanova, V; Waseem, NH; Antonio, A; Sahel, JA; Bhattacharya, SS

Background: Rod-cone dystrophies are heterogeneous group of inherited retinal disorders both clinically and genetically characterized by photoreceptor degeneration. The mode of inheritance can be autosomal dominant, autosomal recessive or X-linked. The purpose of this study was to identify mutations...

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Overexpression of 5-HT2C receptors in forebrain leads to elevated anxiety and hypoactivity

Kimura, A; Stevenson, PL; Carter, RN; MacColl, G; French, KL; Simons, JP; Al-Shawi, R; Kelly, V; Chapman, KE; Holmes, MC

The 5-HT2C receptor has been implicated in mood and eating disorders. In general, it is accepted that 5-HT2C receptor agonists increase anxiety behaviours and induce hypophagia. However, pharmacological analysis of the roles of these receptors is hampered by the lack of selective ligands and the com...

DRIVER (French)


Molecular mechanisms underlying morphological effects of protein kinase C under normal conditions and cellular stress.

Sunesson, Lovisa

The protein kinase C (PKC) family of serine/threonine kinases consists of 10-15 members. The PKC isoforms have central roles in many essential cellular processes, including proliferation, apoptosis, differentiation, cytoskeletal changes, and migration. The PKC family can be subgrouped into classical...

DRIVER (French)


Messenger RNA for G1 protein of French bean seeds: Cell-free translation and product characterization

Pyne, J. W.; Hall, T. C.; Buchbinder, B. U.; Ma, Y.; Sun, S. M.; Bliss, F. A.

The fraction of poly(A)-containing RNA isolated from ripening bean (Phaseolus vulgaris) cotyledons that sedimented at 16 S in linear logarithmic sucrose gradients was at least as active a messenger as viral RNA when added to a cell-free protein-synthesizing system from wheat germ. The major products...

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LTP but not seizure is associated with up-regulation of AKAP-150

Genin, A; French, P; Doyere, V; Davis, S; Errington, ML; Maroun, M; Stean, T; Truchet, B; Webber, M; Wills, T; Richter-Levin, G

We have used differential display to profile and compare the mRNAs expressed in the hippocampus of freely moving animals after the induction of long-term potentiation (LTP) at the perforant path-dentate gyrus synapse with control rats receiving low-frequency stimulation. We have combined this with i...

DRIVER (French)


Isolation and translation of hemoglobin messenger RNA from thalassemia, sickle cell anemia, and normal human reticulocytes

Nienhuis, Arthur W.; Anderson, W. French

Human hemoglobin messenger RNA was isolated by sucrose gradient centrifugation from reticulocytes of patients having various hemolytic anemias. Using a messenger RNA-dependent cell-free system derived entirely from rabbit reticulocytes, the human hemoglobin messenger RNA has been translated and the ...

DRIVER (French)


Intercistronic as well as terminal sequences are required for efficient amplification of brome mosaic virus RNA3.

French, R; Ahlquist, P

The genome of brome mosaic virus (BMV) is divided among messenger polarity RNA1, RNA2, and RNA3 (3.2, 2.9, and 2.1 kilobases, respectively). cis-Acting sequences required for BMV RNA amplification were investigated with RNA3. By using expressible cDNA clones, deletions were constructed throughout RN...

DRIVER (French)


Initiation of Hemoglobin Synthesis: Comparison of Model Reactions That Use Artificial Templates with Those Using Natural Messenger RNA

Crystal, Ronald G.; Anderson, W. French

Partial reactions designed to study the individual steps in the initiation of protein synthesis may be divided into two groups: artificial models using artificial mRNA templates and natural models using naturally occurring mRNA. The requirements for each of the reticulocyte initiation factors, IF-M1...

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Hemoglobin Switching in Sheep and Goats: Change in Functional Globin Messenger RNA in Reticulocytes and Bone Marrow Cells

Nienhuis, Arthur W.; Anderson, W. French

Anemia causes a change in the type of circulating hemoglobin in goats and certain sheep: HbA (α2β2A) is replaced by HbC (α2β2C). We have isolated globin mRNA from erythroid cells of anemic and nonanemic animals to investigate the mechanism whereby anemia causes this switch. To study several stages i...

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Differential amplification of intron-containing transcripts reveals long term potentiation-associated up-regulation of specific Pde10A phosphodiesterase splice variants

O'Connor, V; Genin, A; Davis, S; Karishma, KK; Doyere, V; De Zeeuw, CI; Sanger, G; Hunt, SP; Richter-Levin, G; Mallet, J

We employed differential display of expressed mRNAs (Liang, P., and Pardee, A. B. (1992) Science 257, 967-971) to identify genes up-regulated after long term potentiation (LTP) induction in the hippocampus of awake adult rats. In situ hybridization confirmed the differential expression of five indep...

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Beyond the basal ganglia

van der Burg, Jorien m

Huntington’s disease (HD) is a fatal, hereditary disorder caused by a mutation in the gene encoding the protein huntingtin. Although mutant huntingtin is ubiquitously expressed throughout the body, HD research has mainly focused on the role of the basal ganglia. Dysfunction of these brain nuclei l...

DRIVER (French)