Sample records for VIE MOYENNE (lifetime)
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1

risque_cancer_sein.pdf


MEDECINE/SCIENCES 2005 ; 21 : 175-80 Facteurs de risque du cancer du sein André Nkondjock, Parviz Ghadirian > Le cancer du sein est une préoccupation majeure REVUES de santé publique. En 2001, plus d'un million de nouveaux cas et 372 969 décès attribuables au A. Nkondjock: McLaughlin cancer du sein ont ...

Institut National de la Sante et de la Recherche Medicale (French)

2

obesite2006_presentation.pdf


Obésité Bilan et évaluation des programmes de prévention et de prise en charge Obésité Bilan et évaluation des programmes de prévention et de prise en charge ISBN 2-85598-852-7 (C) Les éditions Inserm, 2006 101 rue de Tolbiac, 75013 Paris Dans la même collection ¬ Vaccinations. Actualités et perspectives. ...

Institut National de la Sante et de la Recherche Medicale (French)

3

menopause_032004.pdf


Sociétés de spécialités médicales participant au Comité d'Interface Reproduction Humaine Fédération des Gynécologues et Obstétriciens de Langue Française (FGOLF) Société Française pour l'Etude de la Fertilité (SFEF) Société Française de Gynéco-Pathologie (SFGP) Fédération Française des CECOS (Centres ...

Institut National de la Sante et de la Recherche Medicale (French)

4

expertise collective


Jeux de hasard et d'argent Contextes et addictions Expertise collective Cet ouvrage présente les travaux du groupe d'experts réuni par l'Inserm dans le cadre de la procédure d'expertise collective (annexe 1), pour répondre à la demande de la Direction générale de la santé sur la problématique de santé ...

Institut National de la Sante et de la Recherche Medicale (French)

5

couv-autopsie_psychologique.indd


Cet ouvrage présente les travaux du groupe de travail réuni par l'Inserm dans le cadre de la procédure d'expertise opérationnelle pour répondre à la demande de la Direction générale de la santé (DGS) concernant l'autopsie psychologique, sa mise en oeuvre et les démarches associées. Il constitue un prolongement ...

Institut National de la Sante et de la Recherche Medicale (French)

6

cannabis_effets_comportements_sante_2001.pdf


Cannabis Quels effets sur le comportement et la santé ? Cannabis Quels effets sur le comportement et la santé ? ISBN 2-85598-800-4 (C) Les éditions Inserm, 2001 101 rue de Tolbiac, 75013 Paris Dans la même collection ¬ La Grippe. Stratégies de vaccination. 1994 ¬ Artériopathie des membres inférieurs. ...

Institut National de la Sante et de la Recherche Medicale (French)

7

alcool_effets_sur_sante_2001.pdf


Expertise collective Alcool Effets sur la santé Ce document présente la synthèse et les recommandations du groupe d'ex- perts réunis par l'Inserm dans le cadre de la procédure d'expertise collective, pour répondre aux questions posées par le Comité français d'éducation pour la santé (CFES), la Caisse ...

Institut National de la Sante et de la Recherche Medicale (French)

8

Toward the clinical application of time-domain fluorescence lifetime imaging

Munro, I; McGinty, J; Galletly, N; Requejo-Isidro, J; Lanigan, PMP; Elson, DS; Dunsby, C; Neil, MAA; Lever, MJ; Stamp, GWH

High-speed (video-rate) fluorescence lifetime imaging (FLIM) through a flexible endoscope is reported based on gated optical image intensifier technology. The optimization and potential application of FLIM to tissue autofluorescence for clinical applications are discussed. (c) 2005 Society of Photo-...

DRIVER (French)

9

Tomographic imaging of Fluorescence Resonance Energy Transfer in highly light scattering media

Soloviev, VY; McGinty, J; Tahir, KB; Laine, R; Stuckey, DW; Mohan, PS; Hajnal, JV; Sardini, A; French, PMW; Arridge, SR

Three-dimensional localization of protein conformation changes in turbid media using Forster Resonance Energy Transfer was investigated by tomographic fluorescence lifetime imaging. We show that Forster Resonance Energy Transfer can be localized by reconstructing the quantum yield and lifetime distr...

DRIVER (French)

10

Time-resolved fluorescence anisotropy imaging applied to live cells

Suhling, K; Siegel, J; Lanigan, PMP; Leveque-Fort, S; Webb, SED; Phillips, D; Davis, DM; French, PMW

We have developed a wide-field time-resolved imaging system to image quantitatively both the fluorescence lifetime and the rotational correlation time of a fluorophore. Using a polarization-resolved imager, we simultaneously image orthogonal polarization components of the fluorescence emission onto ...

DRIVER (French)

11

Time-Domain Fluorescence Lifetime Tomography

McGinty, J; Tahir, KB; Soloviev, VY; Laine, R; Sardini, A; Talbot, CB; Dunsby, C; Munro, I; Elson, DS; Hajnal, JV; Neil, MAA

DRIVER (French)

12

Three-dimensional imaging of Forster resonance energy transfer in heterogeneous turbid media by tomographic fluorescent lifetime imaging

McGinty, J; Soloviev, VY; Tahir, KB; Laine, R; Stuckey, DW; Hajnal, JV; Sardini, A; French, PMW; Arridge, SR

We report a three-dimensional time-resolved tomographic imaging technique for localizing protein-protein interaction and protein conformational changes in turbid media based on Forster resonant energy-transfer read out using fluorescence lifetime. This application of "tomoFRET" employs an inverse sc...

DRIVER (French)

13

The optical links of the ATLAS SemiConductor tracker

Wilson, J. A.; Abdesselam, A.; Allport, P. P.; Apsimon, R. J.; Band, C.; Barr, A. J.; Batchelor, L.

28 pages, 17 figures.-- PACS nrs.: 42.88.+h, 04.40.Nr, 85.40, 85.60.-- ISI Article Identifier: 000253652000008.-- Open Access article at the publisher's site. | Optical links are used for the readout of the 4088 silicon microstrip modules that make up the SemiConductor Tracker of the ATLAS experimen...

DRIVER (French)

14

The optical links of the ATLAS SemiConductor tracker

Wilson, JA; Abdesselam, A; Allport, PP; Apsimon, RJ; Band, C; Barr, AJ; Batchelor, L; Bates, R; Bell, P; Bernabeu, J; Bizzell, J

Optical links are used for the readout of the 4088 silicon microstrip modules that make up the SemiConductor Tracker of the ATLAS experiment at the CERN Large Hadron Collider (LHC). The optical link requirements are reviewed, with particular emphasis on the very demanding environment at the LHC. The...

DRIVER (French)

15

Texte+integral+Alzheimer+enjeux+%282007%29.pdf


Expertise collective Maladie Maladie d'Alzheimer Enjeux scientifiques, médicaux et sociétaux d'Alzheimer Enjeux scientifiques, médicaux et sociétaux Maladie La maladie d'Alzheimer est une véritable pathologie et non un simple effet du vieillissement même si elle d'Alzheimer se révèle, le plus souvent, ...

Institut National de la Sante et de la Recherche Medicale (French)

16

Stimulated emission depletion microscopy with a supercontinuum source and fluorescence lifetime imaging

Auksorius, E; Boruah, BR; Dunsby, C; Lanigan, PMP; Kennedy, G; Neil, MAA; French, PMW

We demonstrate stimulated emission depletion (STED) microscopy implemented in a laser scanning confocal microscope using excitation light derived from supercontinuum generation in a microstructured optical fiber. Images with resolution improvement beyond the far-field diffraction limit in both the l...

DRIVER (French)

17

Socioeconomic position in childhood and in adulthood and functional limitations in midlife: Data from a nationally-representative survey of French men and women.

Melchior, Maria; Lert, France; Martin, Magali; Ville, Isabelle

Research shows that lifetime socioeconomic circumstances are associated with adult health. Yet most studies to date have focused on mortality and additional data on morbidity outcomes are needed. Additionally, most research in this area has been conducted in Northern European countries or in the Uni...

DRIVER (French)

18

Real-time time-domain fluorescence lifetime imaging including single-shot acquisition with a segmented optical image intensifier

Elson, DS; Munro, I; Requejo-Isidro, J; McGinty, J; Dunsby, C; Galletly, N; Stamp, GW; Neil, MAA; Lever, MJ; Kellett, PA

Published (publisher's copy) Peer Reviewed

DRIVER (French)

19

Reading Kate Chopin through contemporary French feminist theory

Worton, M.

Book description: Although she enjoyed only modest success during her lifetime, Kate Chopin is now recognised as a unique voice in American literature. Her seminal novel, The Awakening, published in 1899, explored new and startling territory, and stunned readers with its frank depiction of the limit...

DRIVER (French)

20

Pavement Design for Curved Road Sections: Fatigue Performance of Interfaces and Longitudinal Top-down Cracking in Multilayered Pavements

Petit, Christophe; Diakhaté, Malick; Millien, Anne; Phelipot-Mardelé, Annabelle; Pouteau, Bertrand

This paper focuses on damage processes other than the main one observed and studied in pavement design. Previous research has targeted the experimental fatigue performance of tack coats. The French Pavement Design method has been chosen herein to illustrate how interface fatigue performance can lead...

DRIVER (French)

21

PageDeb-sante.indd


Santé des enfants et des adolescents Propositions pour la préserver Expertise opérationnelle 2e édition Ce document constitue la deuxième édition de l'expertise opérationnelle réalisée par un groupe de travail réuni en 2003 par l'Inserm à la demande de la Caisse nationale d'assurance maladie des travailleurs ...

Institut National de la Sante et de la Recherche Medicale (French)

22

PageDeb-SantÃ(C) Enfants.indd


Expertise opérationnelle Santé de l'enfant Propositions Santé de l'enfant Propositions pour un meilleur suivi pour un meilleur suivi La pratique des examens de santé systématiques chez l'enfant est solidement ancrée en France. Elle est associée à la généralisation du carnet de santé, à la mise en place ...

Institut National de la Sante et de la Recherche Medicale (French)

23

No Job Name


Cet ouvrage présente les travaux du groupe d'experts réunis par l'Inserm dans le cadre de la procédure d'expertise collective, pour répondre aux questions posées par l'Agence française de sécurité sanitaire environnementale (Afsse). Il s'appuie sur les données scientifiques disponibles en date du dernier ...

Institut National de la Sante et de la Recherche Medicale (French)

24

No Job Name


Suicide Autopsie psychologique, outil de recherche en prévention Ce document présente les travaux du groupe d'experts réunis par l'Inserm dans le cadre de la procédure d'expertise collective, pour répondre aux questions posées par la Direction générale de la santé (DGS) concernant l'intérêt de la démarche ...

Institut National de la Sante et de la Recherche Medicale (French)

25

Mémoire : la rencontre de l'hippocampe et de la madeleine - Communiqué de de presse Francis Eustache/Pascale Piolino


Pour en savoir plus "Hippocampal Activation for Autobiographical Memories over the Entire Lifetime in Healthy Aged Subjects : An fMRI Study 1 Armelle Viard ; 1,2 Pascale Piolino ; 1 Béatrice Desgranges ; 1 Gaël Chételat ; 1 Karine Lebreton ; 1 Brigitte Landeau ; 1 Alan Young ; 1 Vincent de La Sayette ...

Institut National de la Sante et de la Recherche Medicale (French)

26

Multifocal multiphoton excitation and time correlated single photon counting detection for 3-D fluorescence lifetime imaging

Kumar, S; Dunsby, C; De Beule, PAA; Owen, DM; Anand, U; Lanigan, PMP; Benninger, RKP; Davis, DM; Neil, MAA; Anand, P; Benham, C

We report a multifocal multiphoton time-correlated single photon counting (TCSPC) fluorescence lifetime imaging (FLIM) microscope system that uses a 16 channel multi-anode PMT detector. Multiphoton excitation minimizes out-of-focus photobleaching, multifocal excitation reduces non-linear in-plane ph...

DRIVER (French)

27

Multidimensional Fluorescence Imaging and Super-resolution Exploiting Ultrafast Laser and Supercontinuum Technology

Auksorius, Egidijus; Auksorius, Egidijus

This thesis centres on the development of multidimensional fluorescence imaging tools, with a particular emphasis on fluorescence lifetime imaging (FLIM) microscopy for application to biological research. The key aspects of this thesis are the development and application of tunable supercontinuum ex...

DRIVER (French)

28

Multi-Dimensional Fluorescence Microscopy for Förster Resonance Energy Transfer Studies of Cell Signaling

Grant, David Mitchell; Grant, David Mitchell

This thesis discusses the development of novel multi-dimensional fluorescence microscopy, particularly fluorescence lifetime imaging (FLIM) technology, and its application to imaging Förster Resonance Energy Transfer (FRET) events in live cells. Particular emphasis is placed on imaging activation of...

DRIVER (French)

29

Imaging fluorescence lifetime heterogeneity applied to GFP-tagged MHC protein at an immunological synapse

Treanor, B; Lanigan, PMP; Suhling, K; Schreiber, T; Munro, I; Neil, MAA; Phillips, D; Davis, DM; French, PMW

Fluorescence imaging of green fluorescent protein (GFP) may be used to locate proteins in live cells and fluorescence lifetime imaging (FLIM) may be employed to probe the local microenvironment of proteins. Here we apply FLIM to GFP-tagged proteins at the cell surface and at an inhibitory natural ki...

DRIVER (French)

30

High speed optically sectioned fluorescence lifetime imaging permits study of live cell signaling events

Grant, DM; McGinty, J; McGhee, EJ; Bunney, TD; Owen, DM; Talbot, CB; Zhang, W; Kumar, S; Munro, I; Lanigan, PMP; Kennedy, GT

We present a time domain optically sectioned fluorescence lifetime imaging (FLIM) microscope developed for high-speed live cell imaging. This single photon excited system combines wide field parallel pixel detection with confocal sectioning utilizing spinning Nipkow disc microscopy. It can acquire f...

DRIVER (French)

31

Fluorescence lifetime tomography of live cells expressing enhanced green fluorescent protein embedded in a scattering medium exhibiting background autofluorescence

Soloviev, VY; McGinty, J; Tahir, KB; Neil, MAA; Sardini, A; Hajnal, JV; Arridge, SR; French, PMW

We present a novel fluorescence lifetime tomography system applied to a highly scattering autofluorescent phantom containing live cells expressing the fluorophore enhanced green fluorescent protein (EGFP). The fluorescence signal was excited using a fiber-laser-pumped supercontinuum source and detec...

DRIVER (French)

32

Fluorescence lifetime imaging through turbid media reconstructed in the Fourier domain using time-gated imaging data - art. no. 66291V

Soloviev, VY; Tahir, KB; McGinty, J; Elson, DS; Neil, M; Sardini, A; Hajnal, J; Arridge, SR; French, PMW

We report a novel technique to reconstruct fluorescence lifetime distributions in turbid media by using Fourier domain reconstruction of time gated imaging data. The time gating provides sufficient temporal resolution to determine short fluorescence lifetimes while the use of the Fourier transform, ...

DRIVER (French)

33

Fluorescence lifetime imaging provides enhanced contrast when imaging the phase-sensitive dye di-4-ANEPPDHQ in model membranes and live cells

Owen, DM; Lanigan, PMP; Dunsby, C; Munro, I; Grant, D; Neil, MAA; French, PMW; Magee, AI

We apply fluorescence lifetime imaging to the membrane phase-sensing dye di-4-ANEPPDHQ in model membranes and live cells. We show that the 1700 ps lifetime shift between liquid-disordered and liquid-ordered phases offers greater contrast than the 60 nm spectral shift previously reported. Detection o...

DRIVER (French)

34

Fluorescence lifetime imaging by using time-gated data acquisition

Soloviev, VY; Tahir, KB; McGinty, J; Elson, DS; Neil, MAA; French, PMW; Arridge, SR

The use of the time gating technique for lifetime reconstruction in the Fourier domain is a novel technique. Time gating provides sufficient data points in the time domain for reliable application of the Fourier transform, which is essential for the time deconvolution of the system of the integral e...

DRIVER (French)

35

Fluorescence lifetime imaging by asynchronous pump-probe microscopy.

Gratton, E; Dong, C Y; French, T; So, P T

We report the development of a scanning lifetime fluorescence microscope using the asynchronous, pump-probe (stimulated emission) approach. There are two significant advantages of this technique. First, the cross-correlation signal produced by overlapping the pump and probe lasers results in i) an a...

DRIVER (French)

36

Fluorescence Lifetime Imaging Provides Enhanced Contrast when Imaging the Phase-Sensitive Dye di-4-ANEPPDHQ in Model Membranes and Live Cells

Munro, Ian; Owen, Dylan M.; Dunsby, Christopher; Lanigan, Peter M. P.; Grant, David; Magee, Anthony I.; Neil, Mark A. A.

We apply fluorescence lifetime imaging to the membrane phase-sensing dye di-4-ANEPPDHQ in model membranes and live cells. We show that the 1700 ps lifetime shift between liquid-disordered and liquid-ordered phases offers greater contrast than the 60 nm spectral shift previously reported. Detection o...

DRIVER (French)

37

Cumulative number of menstrual cycles and breast cancer risk: results from the E3N cohort study of French women.

Clavel-Chapelon, Françoise

OBJECTIVE: To examine the relationship between breast cancer risk and the cumulative number of cycles before a first full-term pregnancy (FTP) and lifetime, taking age at menarche and at onset of regular cycling, periodicity and regularity of cycles, duration of periods of pregnancy, and lactation, ...

DRIVER (French)

38

Application of the stretched exponential function to fluorescence lifetime imaging.

French, P M; Lévêque-Fort, S; Lee, K C; Webb, S E; Siegel, J; Cole, M J; Lever, M J; Jones, R; Dowling, K

Conventional analyses of fluorescence lifetime measurements resolve the fluorescence decay profile in terms of discrete exponential components with distinct lifetimes. In complex, heterogeneous biological samples such as tissue, multi-exponential decay functions can appear to provide a better fit to...

DRIVER (French)

39

An electronically tunable ultrafast laser source applied to fluorescence imaging and fluorescence lifetime imaging microscopy

Lanigan, PMP; Dunsby, C; McGinty, J; Elson, DS; Requejo-Isidro, J; Munro, I; Galletly, N; Treanor, B; Onfelt, B; McCann, F

We demonstrate that spectral selection from a supercontinuum generated in a microstructured fibre can provide a continuously electronically tunable ultrafast spatially coherent source for confocal microscopy and both scanning and wide field fluorescence lifetime imaging. (c) 2005 Optical Society of ...

DRIVER (French)

40

An electronically tunable ultrafast laser source applied to fluorescence imaging and fluorescence lifetime imaging microscopy

Dunsby, C; Lanigan, PMP; McGinty, J; Elson, DS; Requejo-Isidro, J; Munro, I; Galletly, N; McCann, F; Treanor, B; Onfelt, B

Fluorescence imaging is used widely in microscopy and macroscopic imaging applications for fields ranging from biomedicine to materials science. A critical component for any fluorescence imaging system is the excitation source. Traditionally, wide-field systems use filtered thermal or arc-generated ...

DRIVER (French)

41

Burrows, S.

DRIVER (French)

42

Paulhan, Jean; Bajorek, Jennifer; Trudel, Eric; Mandell, Charlotte

Jean Paulhan was a legendary editorial figure of twentieth-century French literature, assisting and publishing many of the most important writers of his lifetime. He was also the author of several volumes of fiction and numerous essays dealing with literature, art, rhetoric, and language. Yet he pub...

DRIVER (French)

43

345_Rufer_MS


MEDECINE/SCIENCES 2003 ; 19 : 345-50 Télomérase, élixir de jouvence des cellules > Les télomères sont des structures spécialisées humaines ? qui protègent les extrémités des chromosomes REVUES Nathalie Rufer, Markus Nabholz chez les eucaryotes. L'existence de ces structures a été démontrée il y a soixante ...

Institut National de la Sante et de la Recherche Medicale (French)

44

330172p-p2ouvrage


Santé des enfants et des adolescents Propositions pour la préserver ISBN 2-85598-813-6 (C) Les éditions Inserm, 2003 101 rue de Tolbiac, 75013 Paris Dans la collection Expertise collective ¬ Hépatites virales. Dépistage, prévention, traitement. 1997 ¬ Grande prématurité. Dépistage et prévention du risque. ...

Institut National de la Sante et de la Recherche Medicale (French)

45

320281S-p1-3synthese


Alcool Dommages sociaux Abus et dépendance Alcool Dommages sociaux, abus et dépendance ISBN 2-85598-820-9 (C) Les éditions Inserm, 2003 101 rue de Tolbiac, 75013 Paris Dans la même collection ¬ Méningites bactériennes. Stratégies de traitement et de prévention. 1996 ¬ Imagerie médicale en France dans ...

Institut National de la Sante et de la Recherche Medicale (French)

46

0000.pdf


Tabac Comprendre la dépendance pour agir Cet ouvrage présente les travaux du groupe d'experts réunis par l'Inserm dans le cadre de la procédure d'expertise collective, pour répondre aux questions posées par la Mission interministérielle de lutte contre la drogue et la toxicomanie (Mildt) concernant la ...

Institut National de la Sante et de la Recherche Medicale (French)