Sample records for TRANQUILIZANTES (tranquilizers)
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Sample records 1 - 14 shown.



1

Análisis de la frecuencia de experimentación y consumo de drogas de alumnos de escuelas de nivel medio/ Análise da frequência de experimentação e consumo de drogas em alunos de escolas de Ensino Médio/ Analysis of the frequency of experimentation with and consumption of drugs in high-school students

Soledad Burrone, Maria; Bueno, Sonia Maria Villela; Costa Jr, Moacyr Lobo de; Enders, Julio; Fernández, Ruth Alicia; Vasters, Gabriela Pereira
2010-06-01

Resumen en portugués Este estudo teve como objetivo analisar a frequência de experimentação e consumo de drogas em alunos de escolas médias de Córdoba, Argentina, relacionada às variáveis sociodemográficas. Trata-se de estudo observacional e analítico, baseado no cadastro da Secretaria de Programação para a Prevenção da Drogadição e Luta contra o Narcotráfico. O processamento estatístico foi de análise bivariada, razão de risco e intervalos de confiança para cada variável (mas) . O consumo de álcool foi mais frequente entre os rapazes, 12,2% dos adolescentes experimentaram algum tipo de droga ilegal. Os tranquilizantes são os psicofármacos mais empregados. O valor do consumo de drogas cresce conforme o aumento da faixa etária, o nível de estudos e a disponibilidade de dinheiro. As descobertas do presente trabalho identificaram realidade epidemiológica útil para desenvolver estratégias de prevenção da adição em adolescentes. Resumen en español En el presente trabajo se analiza la frecuencia de experimentación y consumo de drogas, en alumnos de escuelas de nivel medio de Córdoba, Argentina, en relación a variables sociodemográficas. De carácter analítico, la investigación se basó en los registros de la Secretaría de Programación para la Prevención de la Drogadicción y la Lucha contra el Narcotráfico. El procesamiento estadístico fue análisis bivariado, razón de riesgo e intervalos de confianza pa (mas) ra cada variable. El consumo de alcohol fue más frecuente en los hombres, el 12,2% de los adolescentes probó algún tipo de droga ilícita, y los tranquilizantes son los psicofármacos más utilizados. El valor del consumo de drogas aumenta según aumenta el rango de edad, año de estudio y disponibilidad de dinero. Los hallazgos del presente trabajo identificaron una realidad epidemiológica que permitirá elaborar estrategias de prevención de adicción en los adolescentes. Resumen en inglés The aim of this study was to survey the frequency of experimentation and consumption of drugs in high-school students in Cordoba, Argentina, relating it to socio-demographic variables. An observational-analytical method was employed, on the basis of the records of the Secretary for the Planning of Drug-Addiction Prevention and Fighting of Drug-Trafficking. Statistical. Bivariate analysis, odds ratio and confidence interval were applied in the processing of each variable. (mas) Alcohol consumption was found to be more frequent among males. Of the subjects 12.2% had tried some type of illicit substance. Tranquilizers were the most commonly used psycho-medicine. Drug consumption increased with age, years of schooling and availability of money. Our detection of an epidemiological situation is deemed useful for prevention strategies for drug addiction among teenagers.

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2

Uso y actitudes relacionados a las drogas en las estudiantes de enfermería de la Universidad Mayor de San Andrés/ Use and attitudes about drugs among nursing students at the Universidad Mayor de San Andres/ Uso e atitudes relacionados às drogas em estudantes de enfermagem da Universidade Maior de San Andres

Enriquez Flores, Iblin Elizabeth; Luis, Margarita Antonia Villar
2004-04-01

Resumen en portugués Este trabalho representa os resultados do Uso e Atitudes relacionados ao álcool, tabaco, folhas de coca, tranqüilizantes e anfetaminas em estudantes de enfermagem da Universidade Mayor de San Andrés. O objetivo é analisar as atitudes mediante o uso das diferentes substâncias com aqueles que usaram ou não drogas nos últimos 12 meses. Os dados da amostra estratificada e intencional foram coletados em agosto de 2002, utilizando um questionário auto administrado distr (mas) ibuído para preservar o anonimato. Obtiveram-se estes resultados: as atitudes relacionadas às drogas demonstram a aprovação do uso das folhas de coca, álcool, tranqüilizantes e desaprovam o uso da cocaína. O uso pessoal de drogas nos últimos 12 meses corresponde a: às folhas de coca diariamente, ao álcool menos que uma vez por semana, e tabaco diariamente. O principal motivo do uso destas drogas vincula-se a prática religiosa; os estudantes são introduzidos pela primeira vez pelos familiares, pelos amigos/enamorados. Resumen en español Este trabajo representa los resultados del Uso y Actitudes relacionando el alcohol, tabaco, Hojas de coca, tranquilizantes y anfetaminas en Estudiantes de Enfermería de la Universidad Mayor de San Andrés. El objetivo es analizar las actitudes mediante el uso de diferentes substancias con aquellos que no usan en los últimos 12 meses. Los datos fueron recolectados en Agosto del 2002, utilizando un cuestionario auto administrado y distribuido, garantizando el anonimato. S (mas) e obtuvieron estos resultados: Las actitudes relacionadas a las drogas aprueban el uso de hojas de coca, uso de alcohol, uso de tranquilizantes y desaprueban el uso de cocaína. El uso personal de drogas en los últimos 12 meses corresponde a: hojas de coca diariamente, alcohol menos que una vez por semana y tabaco diariamente. El principal motivo de uso de estas drogas vinculase a la práctica religiosa; los estudiantes son introducidos por primera vez por familiares y por amigos/enamorados. Resumen en inglés This study presents the results of a research that examined the Use and Attitudes about alcohol, tobacco, coca leaves, tranquilizers and amphetamines among Nursing Students at the Universidad Mayor de San Andrés who had not used these substances over the last 12 months. Data were collected in August 2002 by means of a self-administered and distributed questionnaire, which guaranteed anonymity. The following results were obtained: Attitudes related to drugs approve of coc (mas) a leaf and tranquilizer use and disapprove of cocaine. Personal use of drugs during the last 12 months corresponds to: daily use of coca leaves, alcohol less than once per week and tobacco every day. The main reason for using these drugs is related to religious practice; the students' first contact with drugs occurs through family members and (girl or boy) friends.

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3

Registro y análisis de algunas variables epidemiológicas relacionadas con las malformaciones congénitas mayores

Dyce Gordon, Elisa; Chikuy Ferrá, Miriam; Ortiz Magariño, Carlos; Dyce Gordon, Lilian
1999-08-01

Resumen en español Se realizó estudio de casos y controles sobre algunas variables epidemiológicas relacionadas con las 42 malformaciones congénitas mayores clínicamente más severas, presentadas en dos áreas de salud del municipio Camagüey desde enero de 1986 hasta diciembre de 1994. Los datos fueron obtenidos de las planillas del Registro Provincial de Malformaciones Congénitas, certificados de defunción, historias clínicas familiares de los consultorios del Médico de la Familia (mas) , historias clínicas de riesgo genético y pediátricas, así como entrevistas a los padres. Las malformaciones más frecuentes fueron las del aparato cardiovascular. El antecedente de aborto espontáneo y la amenaza de aborto estuvieron relacionadas con el 9,52 y 21,6 % de los malformados respectivamente. Una posible asociación causal se encontró con la ingestión de alcohol, la exposición al calor y la gripe. Estadísticamente significativa resultó la asociación entre la ingestión materna de tranquilizantes y analgésicos, y la presencia de malformaciones. Estos factores ambientales deben evitarse durante el embarazo y mantenerse en el área una estrecha vigilancia sobre ellos, lo cual se logra a través del registro de estos defectos. Resumen en inglés A case-control study on some epidemiological variables connected with the 42 most clinically severe major congenital malformations reported in 2 health areas of Camagüey municipality from January, 1986,to December, 1994, was conducted. Data were obtained from the forms of the Provincial Registry of Congenital Malformations, death certificates, family medical histories of the family physicians offices, medical histories of genetic risk and pediatrics and from interviews t (mas) o parents. The most frequent malformations were those of the cardiovacular system. Histories of miscarriage and threatened abortion were related to 9,52 and 21,6 % of the malformed, respectively. A possible causal association with alcohol ingestion, exposure to heat and flu was found. The relationship between the maternal ingestion of tranquilizers and analgesics and the presence of malformations was statistically significant. These environmental factors must be avoided during pregnancy and a close surveillance must be kept in the areas, which is possible through the registry of these defects.

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4

Consumo de drogas y violencia laboral en mujeres trabajadoras de Monterrey, N. L., México/ Drug consumption and occupational violence in working women of Monterrey, N. L., Mexico/ Consumo de drogas e violência ocupacional em mulheres trabalhadoras de Monterrey, N. L. México

Castillo, Maria Magdalena Alonso; Caufield, Catherine; Gómez Meza, Marco Vinicio
2005-12-01

Resumen en portugués O propósito do estudo foi explorar o consumo de drogas e violência ocupacional em uma amostra de 669 mulheres maiores de idade, que trabalham e moram em treze Áreas Geo-Estatísticas Básicas de Monterrey, Nuevo León, México. Foi adotado um desenho descritivo e correlacional com abordagem qualitativa. Resultados revelaram que 37,1% das mulheres consumiram álcool, 29,1% tabaco, 0.4% maconha, 0,1% inaláveis e, entre as drogas médicas, 5% consumiu tranqüilizantes e (mas) 1,0% outras sustâncias (barbitúricos, antidepressivos, Tylenol/Codeína). O teste qui-quadrado não encontrou diferença significativa dos fatores sócio-demográficos e ocupacionais com o consumo de drogas (p>.05), exceto com a forma de trabalho (c²=18.08, gl=4, p=.001). No entanto, o índice de violência mostrou associação positiva com o consumo de drogas (p Resumen en español El propósito de este estudio fue explorar el consumo de drogas y violencia laboral en una muestra de 669 mujeres mayores de edad, que trabajaban y vivían en trece Áreas Geoestadísticas Básicas de Monterrey, Nuevo León, México. Se adoptó un diseño descriptivo y correlacional con aproximación cualitativa. Los resultados revelaron que el 37.1% de las mujeres consumió alcohol, el 29.1% tabaco, el 0.4% marihuana, el 0.1% inhalables y, entre las drogas médicas, el 5 (mas) % consumió tranquilizantes y el 1.0% otras sustancias (barbitúricos, antidepresivos, Tylenol/codeína). La prueba chi-cuadrada no encontró diferencia significativa de los factores sociodemográficos y laborales con el consumo de drogas (p>.05), a excepción de la forma de trabajo (c2=18.08, gl=4, p=.001). Sin embargo, el índice de violencia mostró asociación positiva con el consumo de drogas (p Resumen en inglés The purpose of this study was to explore drug consumption and occupational violence in a sample of 669 adult women, working and living in 13 basic geostatistical areas of Monterrey, Nuevo León, México, using a descriptive correlational design with a qualitative approach. Results indicated that 37.1% of women consumed alcohol, 29.1% tobacco, 0.4% marihuana, 0.1% inhalants, and, among medical drugs, 5% consumed tranquilizers, and 1% other substances (barbiturates, antidep (mas) ressive agents, Tylenol/codeine). The c² test found no significant difference between sociodemographic and occupational factors and drug consumption (p

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5

Desgaste profesional en el personal sanitario y su relación con los factores personales y ambientales/ Burnout syndrome in health workers and relationship with personal and environmental factors

Grau, Armand; Suñer, Rosa; García, María M.; Grupo de Estudio del Síndrome de Desgaste Profesional en los Hospitales de Girona
2005-12-01

Resumen en español Objetivos: Entre los profesionales sanitarios se han hallado altos índices de desgaste profesional. Nuestro objetivo fue estudiar la prevalencia del síndrome de desgaste profesional en los trabajadores sanitarios hospitalarios, y valorar su relación con los factores personales y ambientales. Métodos: Un total de 2.290 trabajadores sanitarios de 5 hospitales de Girona fueron invitados a participar. Se les administró un cuestionario de elaboración propia, una encuesta (mas) del clima organizacional, y el Maslach Burnout Inventory, que incluye tres dimensiones: cansancio emocional, despersonalización y baja realización personal. Resultados: Contestaron la encuesta 1.095 trabajadores (con un 47,8% de participación). Un 41,6% presentó un alto nivel de cansancio emocional, sobre todo los médicos y el personal de enfermería; un 23% tuvo un alto nivel de despersonalización, sobre todo los médicos, y un 27,9% tuvo una baja realización personal, en especial los técnicos y los médicos. Mediante un análisis de regresión logística múltiple, se asoció un alto nivel de cansancio emocional al consumo de tranquilizantes o antidepresivos con asiduidad, mientras que el optimismo y la satisfacción profesional mostraron una asociación inversa. Los años de profesión, el optimismo, valorar como útil el trabajo y percibir que se es valorado por los demás se asociaron inversamente con un alto nivel de despersonalización. La baja realización personal se asoció inversamente con el optimismo, la valoración de la utilidad del trabajo y el equipo de trabajo. Conclusiones: A partir de los resultados obtenidos, recomendamos mejorar el clima organizacional y potenciar el optimismo y la autoestima individual, para disminuir el desgaste profesional en los hospitales. Resumen en inglés Objectives: High rates of professional burnout syndrome have been found among health service professionals. Our objective was to study the prevalence of burnout syndrome in hospital health workers and to determine its relationship with personal and environmental factors. Methods: A total of 2290 health workers from five hospitals in the province of Girona (Spain) were invited to participate. Interviewees were given a specifically designed questionnaire, a questionnaire on (mas) organizational climate, and the Spanish version of the Maslach Burnout Inventory, which includes three scales: emotional exhaustion, depersonalization, and reduced personal accomplishment. Results: Responses were received from 1095 health workers (a response rate of 47.8%). A high level of emotional exhaustion was found in 41.6% of staff members, especially among doctors and nurses; a high level of depersonalization was found in 23%, mainly among doctors, and reduced personal accomplishment was found in 27.9%, mainly among technicians and doctors. Multiple logistic regression revealed that a high level of emotional exhaustion was associated with frequent consumption of tranquilizers or antidepressants, whereas optimism and job satisfaction showed an inverse association. The variables that were inversely associated with a high level of depersonalization were the number of years in the profession, optimism, evaluation of work as being useful and the perception of being valued by others. Reduced personal accomplishment was also inversely associated with optimism, satisfaction with the usefulness of one's work, and satisfaction with teamwork. Conclusions: In view of the results obtained, to reduce professional burnout in hospitals, optimism and a sense of self-worth among individuals should be encouraged and the organizational environment should be improved.

Scientific Electronic Library Online (Spanish)

6

Desgaste profesional en el personal sanitario y su relación con los factores personales y ambientales/ Burnout syndrome in health workers and relationship with personal and environmental factors

Grau, Armand; Suñer, Rosa; García, María M.; Grupo de Estudio del Síndrome de Desgaste Profesional en los Hospitales de Girona
2005-12-01

Resumen en español Objetivos: Entre los profesionales sanitarios se han hallado altos índices de desgaste profesional. Nuestro objetivo fue estudiar la prevalencia del síndrome de desgaste profesional en los trabajadores sanitarios hospitalarios, y valorar su relación con los factores personales y ambientales. Métodos: Un total de 2.290 trabajadores sanitarios de 5 hospitales de Girona fueron invitados a participar. Se les administró un cuestionario de elaboración propia, una encuesta (mas) del clima organizacional, y el Maslach Burnout Inventory, que incluye tres dimensiones: cansancio emocional, despersonalización y baja realización personal. Resultados: Contestaron la encuesta 1.095 trabajadores (con un 47,8% de participación). Un 41,6% presentó un alto nivel de cansancio emocional, sobre todo los médicos y el personal de enfermería; un 23% tuvo un alto nivel de despersonalización, sobre todo los médicos, y un 27,9% tuvo una baja realización personal, en especial los técnicos y los médicos. Mediante un análisis de regresión logística múltiple, se asoció un alto nivel de cansancio emocional al consumo de tranquilizantes o antidepresivos con asiduidad, mientras que el optimismo y la satisfacción profesional mostraron una asociación inversa. Los años de profesión, el optimismo, valorar como útil el trabajo y percibir que se es valorado por los demás se asociaron inversamente con un alto nivel de despersonalización. La baja realización personal se asoció inversamente con el optimismo, la valoración de la utilidad del trabajo y el equipo de trabajo. Conclusiones: A partir de los resultados obtenidos, recomendamos mejorar el clima organizacional y potenciar el optimismo y la autoestima individual, para disminuir el desgaste profesional en los hospitales. Resumen en inglés Objectives: High rates of professional burnout syndrome have been found among health service professionals. Our objective was to study the prevalence of burnout syndrome in hospital health workers and to determine its relationship with personal and environmental factors. Methods: A total of 2290 health workers from five hospitals in the province of Girona (Spain) were invited to participate. Interviewees were given a specifically designed questionnaire, a questionnaire on (mas) organizational climate, and the Spanish version of the Maslach Burnout Inventory, which includes three scales: emotional exhaustion, depersonalization, and reduced personal accomplishment. Results: Responses were received from 1095 health workers (a response rate of 47.8%). A high level of emotional exhaustion was found in 41.6% of staff members, especially among doctors and nurses; a high level of depersonalization was found in 23%, mainly among doctors, and reduced personal accomplishment was found in 27.9%, mainly among technicians and doctors. Multiple logistic regression revealed that a high level of emotional exhaustion was associated with frequent consumption of tranquilizers or antidepressants, whereas optimism and job satisfaction showed an inverse association. The variables that were inversely associated with a high level of depersonalization were the number of years in the profession, optimism, evaluation of work as being useful and the perception of being valued by others. Reduced personal accomplishment was also inversely associated with optimism, satisfaction with the usefulness of one's work, and satisfaction with teamwork. Conclusions: In view of the results obtained, to reduce professional burnout in hospitals, optimism and a sense of self-worth among individuals should be encouraged and the organizational environment should be improved.

Scientific Electronic Library Online (Spanish)

7

Consumo de alcohol y drogas en estudiantes de Pachuca, Hidalgo/ Alcohol and drug consumption among students from Pachuca, Hidalgo

Rojas-Guiot, Estela; Fleiz-Bautista, Clara; Medina-Mora Icaza, María Elena; Morón, Ma. de los Angeles; Domenech-Rodríguez, Melanie
1999-07-01

Resumen en español OBJETIVO. Determinar la prevalencia del consumo de drogas y bebidas alcohólicas entre estudiantes, así como la relación de este consumo con variables sociodemográficas, tiempo libre, actos antisociales, normas y conflictos familiares, entre otras. MATERIAL Y MÉTODOS. Los datos se derivan de una encuesta representativa de 1 929 estudiantes de enseñanza media y media superior de la ciudad de Pachuca, estado de Hidalgo, México, levantada en 1996, de los cuales 44.9% s (mas) on hombres y 52.5% mujeres, con una media de edad de 14 años. Se utilizó un cuestionario autoaplicable, que incluye indicadores de consumo de drogas y alcohol elaborados por algunos países, entre ellos México, con la Organización Mundial de la Salud. RESULTADOS. El 47.9% ha probado bebidas alcohólicas; 12.6% bebieron cantidades considerables -cinco copas o más por ocasión- durante el mes anterior a la encuesta. Las bebidas preferidas son la cerveza y los coolers; el alcohol lo compraron principalmente en tiendas donde no les piden identificación y lo consumen en su casa o en la de otras personas. El 5.1% ha consumido drogas, sobre todo inhalables, mariguana y tranquilizantes. Una cifra mayor de varones consume drogas ilegales, y las mujeres, medicamentos sin prescripción. Un número superior de hombres toma más cantidades de alcohol y consume drogas, tienen mayor edad y trabajaron de medio tiempo durante el año anterior a la encuesta. Los consumidores de drogas y de altas cantidades de alcohol se distinguieron porque un número considerable informó que se aburría en su tiempo libre, se va a beber con sus amigos o ha cometido actos antisociales. Respecto a la familia, manifiestan cumplir menos con las normas parentales y muestran menor interés en hacerlo. Asimismo, un porcentaje más elevado informó que sus padres pelean con frecuencia, han pedido ayuda por esa razón y han intentado separarse. CONCLUSIONES. Los estudiantes que beben cantidades elevadas de alcohol y los consumidores de otras drogas, a diferencia de lo que sucede con los abstemios, presentaron más problemas al destinar su tiempo libre a actividades como irse a beber con amigos, exhibir más conductas antisociales y tener un distanciamiento de la familia que se refleja en la baja participación en actividades compartidas, en el desinterés por cumplir con sus normas y en la percepción de conflictos al interior de la misma. Resumen en inglés OBJECTIVE. To determine the prevalence of alcohol and drug consumption and its relationship to sociodemographic variables, leisure activities, antisocial behavior, family norms and conflicts, among others. MATERIAL AND METHODS. Data derive from a representative survey of 1 929 students of junior high and high school, conducted in 1996 in the city of Pachuca, Hidalgo, Mexico. Of these, 44.9% were boys and 52.5% were girls; mean age was 14. A self-applied questionnaire, pre (mas) pared by the WHO together with some countries, among them Mexico, was completed by the studied subjects, and included indicators of alcohol and drug consumption. RESULTS. Of the total sample, 47.9% had tried alcohol, and 12.6% had drunk large quantities -5 drinks or more per sitting- during the month previous to the survey. Preferred drinks are beer and "coolers", which they buy at shops where no identification is required and drink at home or at friend's homes. With respect to drugs, 5.1% had tried illegal or medical drugs without prescription, in particular inhalants, marihuana and tranquilizers. More boys consumed illegal drugs, and more girls medical drugs without prescription. Boys, who are also older, more frequently consumed alcohol and drugs and were more often employed during the previous year at part-time jobs. High alcohol level and drug consumers were characterized by their frequent report of being bored in their free time, drinking with friends and enrolling in antisocial behavior. With respect to family norms, they follow them less and show less interest in doing so. An elevated percentage informed that their parents fight frequently, that they have sought help for this reason and have intended separation. CONCLUSIONS. Groups who drink more alcohol and use other drugs, in contrast with non-users, presented more behavioral problems, more outdoors activities that included drinking with friends, more antisocial behavior, had a distant relationship with their families sharing few activities with them, an showed little interest in following family rules and perceiving conflicts within their families.

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Uso inapropiado de fármacos de prescripción: dependencia a benzodiazepinas en adultos mayores/ Prescription drugs misuse: benzodiazepine dependence in the elderly

Minaya, Omar; Ugalde, Oscar; Fresán, Ana
2009-10-01

Resumen en español El abuso potencial y el uso inapropiado de fármacos de prescripción en adultos mayores de 65 años o más está en aumento. Aunque la prevalencia de esta condición es difícil de estimar, se sabe que es más frecuente en mujeres. Una gran proporción de los tranquilizantes e hipnóticos son prescritos a adultos mayores. El género femenino, el aislamiento social y una historia de abuso de sustancias y de trastornos mentales son los principales factores de riesgo asocia (mas) dos al uso inapropiado de fármacos. Por otro lado, el uso prolongado de benzodiazepinas (BDZ) -mayor a cuatro semanas- también se ha asociado al desarrollo de dependencia, aun cuando las BDZ se utilicen a dosis terapéuticas Objetivo El objetivo del presente estudio es describir y comparar las características sociodemográficas y clínicas relacionadas con la prescripción y el uso de benzodiazepinas en adultos mayores con y sin dependencia a las mismas en un servicio especializado de psicogeriatría. Método Se reclutó un total de 39 pacientes de la Clínica de Psicogeriatría del Instituto Nacional de Psiquiatría Ramón de la Fuente en la Ciudad de México. Todos los participantes consintieron por escrito su participación en el estudio. El diagnóstico de dependencia a BDZ se realizó a partir del SCID-I; la gravedad de los síntomas de depresión se evaluó mediante la Escala de Montgomery y Asberg (MADRS); los síntomas de ansiedad, con la Escala de Ansiedad de Hamilton (HAM-A), y el nivel de funcionalidad, mediante el Índice de Katz y el GAF. Resultados No se encontraron diferencias significativas entre los grupos en las variables sociodemográficas y la comorbilidad médica. Los pacientes incluidos cursaron en su mayoría con un cuadro depresivo o algún trastorno de ansiedad como diagnóstico principal. La indicación médica inicial para el consumo de BDZ fue el tratamiento de la ansiedad para los pacientes con dependencia y del insomnio para los no dependientes. La edad de inicio del consumo de las BDZ y el tiempo de consumo fue de 57.5 años y 675.2 semanas en promedio, respectivamente. La dosis promedio utilizada por los pacientes fue de 1 4.4mg en equivalentes de diazepam. Los pacientes con dependencia a las BDZ mostraron una mayor gravedad de los síntomas de depresión y ansiedad, menor desempeño cognoscitivo y menor funcionamiento psicosocial, así como conductas de búsqueda y abandono de actividades relacionadas con el consumo y mayores síntomas de tolerancia y abstinencia a las BDZ. Discusión La dependencia a las BDZ se presentó como un fenómeno complejo relacionado con la intensidad de los síntomas de depresión y ansiedad, un consumo crónico y una mayor dosificación. La depresión con síntomas de ansiedad en el adulto mayor no debería tratarse con BDZ, ya que, además del riesgo de desarrollar dependencia, éstas pueden efectuar negativamente el desempeño cognoscitivo y el funcionamiento global de los pacientes. Al momento de prescribir una BDZ a la población geriátrica se deben tomar en consideración variables sociodemográficas y clínicas de los pacientes. De la misma forma, será necesario evaluar en futuros estudios la influencia de la personalidad y otras variables clínicas sobre el desarrollo de esta dependencia. Resumen en inglés Misuse and potential abuse of prescription drugs are growing problems in elderly people over 65 years old. Although the prevalence of this condition is difficult to estimate, drug misuse is most common in elderly women. A great proportion of the psychoactive prescriptions in old people include tranquilizers and hypnotics. There are several risk factors related to increased risk misuse, abuse, and dependence of prescription drugs. The following are among these risk factors (mas) : the female gender, social isolation, history of substance abuse or dependence, history of mental illness and medical exposure to prescription drugs with abuse potential. Also, BDZ consumption for a period longer than four weeks has also been associated to BDZ dependence, even at therapeutic doses. Until now, BDZ dependence in the elderly has been poorly studied, so the present study may increase our knowledge of this complex phenomenon. Objective The aim of the present study was to describe and compare sociodemographic and clinical features related to the prescription and benzodiazepines use in old people with and without dependence to these drugs in an outpatients psychogeriatric service. Method A total of 39 patients from the outpatients service at the psychogeriatric clinic of the National Institute of Psychiatry Ramón de la Fuente in Mexico City were recruited. All of the participants signed an informed consent to be included in the study. Several assessments were performed to determine the psycho-pathological status. Diagnosis of BDZ dependence was obtained with the SCID-I Interview, the severity of depression and anxiety symptoms were evaluated through the Montgomery & Asberg Scale (MADRS) and the Hamilton Anxiety Scale, respectively. For the evaluation of the functionality level, the Katz Index and GAF were used. Results No significant differences were found between patients with and without BDZ dependence in terms of social and demographic characteristics and medical comorbidity. The main Axis I diagnoses of the patients were depressive disorder or anxiety disorders. The first medical prescription of BDZ in patients with BDZ dependence was the presence of anxiety symptoms, while for patients without BDZ dependence the aim of BDZ prescription was the treatment of insomnia. The mean age of BDZ use onset and the time of consumption were 57.5 years and 675.2 weeks, respectively. The average dose of BDZ used by the patients was 14.4mg of diazepam equivalents. Significant differences were found between groups in terms of BDZ consumption features. Patients with BDZ dependence exhibited more drug seeking behavior, more abandonment of daily activities, and more tolerance and abstinence symptoms. Patients with BDZ dependence exhibited more prominent symptoms of anxiety and depression than patients without BDZ dependence. Also, these patients had a poorer cognitive performance and lower psychosocial functioning. Discussion BDZ dependence is a complex phenomenon related to the severity of depressive and anxiety symptoms. These symptoms were the main reason for the medical prescription of BDZ. Although BDZ use was indicated for the treatment of anxiety disorders, the use of BDZ in the elderly has been contraindicated for the treatment of depression with anxiety features. The potential risk to develop BDZ dependence in elderly patients can be related to pharmacological variations due to changes in the metabolism process of aging and the interactions with other drugs. Both factors could increase half life of BDZ and their pharmacological effect in the organism. There were statistical differences in the drug-taking pattern of BDZ consumption in the patients. Patients with BDZ dependence had an earlier onset of BDZ consumption and longer use. The chronic use of BDZ is one of the most important risk factors for dependence development. For the present study, BDZ dependence was clinically defined in terms of tolerance and abstinence symptoms. This definition is in accordance to what has been described in international scientific literature as BDZ physiologic dependence. In this way, tolerance and abstinence symptoms might be the main reason why patients with BDZ dependence needed higher BDZ dosages for the treatment of anxiety symptoms. Sociodemographic characteristics in this sample were not related to the presence of BDZ dependence; nevertheless, it has been reported that the female gender and the presence of chronic pain are risk factors for BDZ abuse and dependence. Future longitudinal studies with an increased number of patients should assess the effect of these variables in BDZ dependence development in the elderly. Differences found in terms of cognitive performance may be related to the psychomotor retardation conferred by the use of BDZ, which may in turn have a direct impact on the velocity of mental performance in the patients. Also, the presence and severity of depressive and anxiety symptoms may also have a negative impact on cognitive performance. Generalization of the findings of the present research is limited by sample size. Nevertheless, the relevance of the present results highlight the importance of the careful prescription and inherent risks related to potentially addictive medications. Increasing our knowledge in the prescription of these medications will improve our medical attention and our patients' quality of life.

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Tendencias del consumo de drogas de 1998 a 2005 en tres ciudades de la zona norte de México: Ciudad Juárez, Monterrey y Tijuana/ Trends of drug use 1998 to 2005 in three cities in the northern zone of Mexico: Ciudad Juarez, Monterrey and Tijuana

Rojas Guiot, Estela; Fleiz Bautista, Clara; Villatoro Velázquez, Jorge; Gutiérrez López, María de Lourdes; Medina-Mora Icaza, María Elena
2009-02-01

Resumen en español El consumo de drogas en México ha ido en aumento. En la década de 1970, el Instituto Nacional de Psiquiatría realizó las primeras encuestas de hogares sobre el tema de las adicciones en población de distintas ciudades del país: la Ciudad de México, La Paz, B.C.S.; Mexicali, B.C.; Monterrey, N.L.; San Luis Potosí, S.L.P., y Puebla, Pue, entre otras y ha documentado las tendencias del problema y sus variaciones regionales. A nivel nacional se han realizado en hogare (mas) s cuatro encuestas en 1988, en 1993, en 1998 y en 2002, denominadas >. Asimismo se han levantado tres encuestas nacionales sobre drogas entre la población estudiantil, las cuales han dado cuenta de que el consumo de drogas no se ha incrementado de manera uniforme en el país, sino que tanto en las encuestas estudiantiles como entre las de adicciones ha resaltado la zona noroccidental, conformada por estados como Baja California, Sonora y Chihuahua, donde se tienen las mayores cifras de consumo de drogas en la República Mexicana. Las encuestas de adicciones indican que la droga que más ha consumido alguna vez en la vida la población urbana de 12 a 65 años es la mariguana, con los siguientes porcentajes: en 1988, 2.99%; en 1993, 3.32%; en 1998, 4.70%; y en la medición de 2002 disminuyó ligeramente a 3.48%. En 1988, el segundo lugar lo ocupaban los inhalables con 0.76%, pero en las demás mediciones ocupa este lugar la cocaína, con 0.56% en 1 993; 1.45% en 1998 y en 2002, 1.23%. En el tercer lugar se encuentran las drogas médicas consumidas sin prescripción desde 1988 hasta 2002. Este artículo presenta una comparación de las prevalencias de uso de drogas en tres ciudades de la Encuesta Nacional de Adicciones de 1998 con respecto a la Encuesta de ciudades de 2005 de las tres ciudades siguientes: Ciudad Juárez, Monterrey y Tijuana. La Encuesta Nacional de Adicciones de 1998 se realizó en una muestra representativa de la población urbana de todo el país (en localidades de más de 2500 habitantes). En esta encuesta, las 32 entidades del país se dividieron en tres regiones y también se obtuvieron muestras en ciudades fronterizas que fueron: Tijuana, Ciudad Juárez y Matamoros y en tres zonas metropolitanas que fueron: La ciudad de México, Guadalajara y Monterrey. La muestra fue de 12015 entrevistas completas. La encuesta de ciudades de 2005 se realizó en cuatro ciudades que fueron: Querétaro, Monterrey, Ciudad Juárez y Tijuana. Sin embargo, para efectos de este trabajo, solamente se comparan las tres últimas. Las dos encuestas tuvieron como objetivo a la población de 12 a 65 años de edad. En ambas se aplicaron dos cuestionarios: el de hogar con datos socioeconómicos y otro individual, cuyas secciones de consumo de drogas fueron iguales. El muestreo en ambas encuestas fue multietápico, probabilístico y estratificado, y en la última etapa se seleccionó a un individuo de cada hogar con un rango de edad de 12 a 65 años. Se obtuvo una no respuesta de 23% en 1998 y de 20.3% en 2005. Resumen en inglés Drug use in Mexico has been on the rise since the 1970s. Nonetheless, this problem has exhibited important variations in the different regions of Mexico. To document these trends, the National Institute of Psychiatry Ramón de la Fuente (INP) has performed household surveys on addictions in different Mexican cities. In the 1970s and early 1980s surveys were conducted in the following cities: Mexico City, La Paz, Baja California Sur; Mexicali, Baja California Norte; Monter (mas) rey, Nuevo León; San Luis Potosí, San Luis Potosí; and Puebla, Puebla, among others. The first national survey in urban population was carried out in 1 988, and was repeated in 1993 and 1998, while the first national survey to included rural population was conducted in 2002, which is being followed by another study currently in the field. The student population has also been extensively studied, and has been included in three national drug surveys and studies performed in different entities. Antecedents Results from these surveys show that drug use has not increased in a uniform fashion throughout the Mexican Republic and both student and household surveys have demonstrated higher rates in the northwestern region of the country comprising the states of Baja California, Sonora and Chihuahua, which have exhibited above-average drug use on comparison with the remaining regions of the country. The most frequently consumed drug by the population is marihuana. The 1988 national household survey registered a rising prevalence in use of 2.9% in Mexican population aged 12-65 years of individuals who had used drugs at some time during their lifetime; in 1993 this prevalence increased to 3.32% and in 1998 to 4.70%; while in 2002 the percentage demonstrated a slight decrease to 3.48%. In 1988, the second place in drug preferences of the population was inhalants with a prevalence of drug use at some time during their lifetime of 0.76%; by 1993, the second place was occupied by cocaine. Prevalence of use of the latter was 0.33% in 1988; by 1993, cocaine increased to 0.56% and to 1.45% in 1998, presenting a slight decrease in use in 2002 (1.23%). From 1988-2002 non-prescribed medical drugs consumed were found in the third place in population preference. Objective This article compared drug use rates observed in three cities on or near Mexico's northern border with the U. S.: Ciudad Juarez, Chihuahua; Tijuana, Baja California Norte, and Monterrey, Nuevo León, were studied as part of the 1 998 national survey on addictions by selecting independent representative samples of these localities and with a new survey of these entities in 2005. Method The 1998 national survey of addictions was carried out in a representative sample of Mexican urban population (in localities of 2500 inhabitants). Independent samples were drawn from inhabitants living in several cities throughout Mexico. In this article we report the drug-use trends for three of these cities (Ciudad Juarez, Monterrey and Tijuana) by comparing the rates observed in 1998 with the results of a new wave of household surveys conducted in 2005 in the same cities using comparable methodology. Samples in both periods included population 12-65 years of age residing in households. Sample design was stratified by means of the following: several stages with localities (Áreas Geoestadísticas Básicas, AGEBS, its acronym in Spanish, census tracts); blocks of houses within the selected localities; segments of houses within sample blocks, and one individual per household as the selection unit in each stage. Sample size in Tijuana was 466 and 553 in 1998 and 2005, respectively, while sample sizes for Ciudad Juarez were 472 in 1998 and 606 in 2005, and for Monterrey this was 637 in 1998 and 675 in 2005, and the non-response rate was 23% in 1 998 and 20.3% in 2005. Instruments for obtaining information employed in both time frames considered were similar. Two types of questionnaires were administered: a household questionnaire that included sociodemographic information on all household inhabitants in the sample and their housing conditions and an standardized individual questionnaire administered in a face-to-face interview that collected information on the following: prevalence and use patterns of tobacco, alcohol, five types of illegal drugs (marihuana, cocaine, heroin, hallucinogens, amphetamine-type stimulants and other drugs); four types of medical pharmaceuticals utilized without a prescription (narcotics, stimulants, tranquilizers and sedatives), determining consequences and services utilization. In this article tobacco and alcohol use is not reported. This questionnaire has been extensively tested and used in previous surveys. Interviewers were persons academically prepared in the Social Sciences and trained in the logistics of the several survey stages and extensively supervised during field work. Results Highest rates of use were observed in Tijuana and Ciudad Juarez in contrast with Monterrey, which had lower rates. When use of any drug was considered, an increase in lifetime use from 1998-2005 was observed in all three cities; when use during the past year was contemplated, an increase was observed from 1998-2005 from 2.8-4.8% in the case of Ciudad Juarez and in Monterrey from 1.3%-2.0%, while these rates for Tijuana decreased from 5.4%-4.01%. Reports of use during the previous month fell in Tijuana from 4.4%-2.81 % and in Monterrey this decreased from 1.1 %-0.71 %, while in Ciudad Juarez drug use rates during the previous month increased from 2.4%-3.24%. It is important to mention that there was no statistical significance in any of the different prevalences types. Lifetime use of medical drugs without prescription increased in Tijuana and in Monterrey, while in Ciudad Juarez this remained stable from 1998-2005. In 2005, use of medical drugs decreased in Ciudad Juarez from 1.2%-0.88% and in Tijuana from 1.3%-1 .28%, while in Monterrey no use was detected in 1998, but 0.48% of interviewees did reported drug use in 2005. Previous-month use increased in Tijuana from 0.7%-1 .28% and in Monterrey this ranged from no use in 1998 to 0.48% by contrast in Ciudad Juarez previous-month drug use fell from 1.2-0.88%. In referring only to use of any illegal drug (excluding medical pharmaceutical), lifetime use increased in all three cities from 1998-2005; lifetime use doubled in Monterrey and Ciudad Juarez, while use during the previous year decreased in Tijuana from 4.4%-3.25% and increased in Ciudad Juarez from 1.6%-3.98% and in Monterrey from 1.3%-1 .52%. Prior-month increased in Ciudad Juarez from 1.2%-2.42%, while this exhibited a decrease in Tijuana from 3.9%-2.05% and in Monterrey from 1.1%-0.23%. Data also indicate that a high proportion of individuals in Monterrey have used only one drug; these percentages rose in the 1998-2005 period from 3.7%-8.96% numbers of the poly-drug users doubled in Tijuana from 4%-8.44% and in Ciudad Juarez from 3.2%-7.43%; in Tijuana this was due to an increase among males, and in Ciudad Juarez the number of poly-drug users increased in both genders.

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Prevalencia de depresión y factores asociados con ella en la población colombiana/ The prevalence of and factors associated with depression in Colombia

Gómez-Restrepo, Carlos; Bohórquez, Adriana; Pinto Masis, Diana; Gil Laverde, Jacky F. A.; Rondón Sepúlveda, Martín; Díaz-Granados, Nancy
2004-12-01

Resumen en español OBJETIVOS: Analizar la prevalencia del síndrome depresivo y los factores asociados con la depresión en Colombia entre los años 2000 y 2001. MÉTODOS: Para este estudio descriptivo de corte transversal se aplicó una encuesta entre noviembre de 2000 y enero de 2001 a 1 116 adultos de 18 años de edad o más de uno u otro sexo que residían en viviendas particulares seleccionadas mediante un muestreo representativo nacional polietápico, estratificado según el grado de (mas) urbanización del área incluida en el muestreo. La depresión se clasificó en breve, subclínica o clínica (leve, moderada o grave) en los 30 días y los 12 meses previos a la entrevista. Se calcularon las frecuencias simples y estratificadas por la edad y el sexo, y los intervalos de confianza de 95% (IC95%) de más de 500 variables. La asociación de las variables seleccionadas con episodios depresivos se evaluó mediante un modelo de regresión logística con múltiples variables. RESULTADOS: De las personas estudiadas, 10,0% (IC95%: 9,2 a 10,7) presentaron algún episodio depresivo en los 12 meses previos a la encuesta y 8,5% (IC95%: 7,8 a 9,2) sufrieron alguno durante el último mes. Hubo una mayor proporción de mujeres con depresión en ambos períodos. Más de 50% de los episodios fueron moderados, tanto en hombres como en mujeres, y las mayores prevalencias se encontraron en las personas mayores de 45 años. Los factores asociados con la depresión en el último mes fueron ser mujer, considerar el estado de salud propio como regular o malo, sufrir de dolores o molestias, tener dificultades en las relaciones interpersonales, consumir marihuana o sustancias adictivas, medicamentos estimulantes o calmantes, tener dependencia del alcohol, o estar desempleado con discapacidad. CONCLUSIÓN: La depresión es una afección frecuente en Colombia. Se deben poner en marcha medidas dirigidas a reducir el riesgo de depresión, especialmente en mujeres y en personas mayores de 45 años de edad. Resumen en inglés OBJECTIVES: To analyze the prevalence of depression and the factors associated with it in Colombia in 2000 and 2001. METHODS: For this descriptive cross-sectional study a survey was conducted between November 2000 and January 2001 with 1 116 men and women 18 years of age or older who were living in private homes that were selected through a multistage national representative sampling, stratified according to the degree of urbanization of the area included in the sampling. (mas) Depression was classified as brief recurrent depression, subclinical depression, or mild, moderate, or serious clinical depressive episodes in the 30 days and in the 12 months prior to the interview. Simple and stratified frequencies of over 500 variables, along with their 95% confidence intervals (95% CIs), were calculated by age and gender. The association that the selected variables had with depressive episodes was evaluated through a multivariate logistic regression model. RESULTS: Of the persons studied, 10.0% of them (95% CI: 9.2% to 10.7%) had had a depressive episode in the 12 months prior to the survey, and 8.5% (95% CI: 7.8% to 9.2%) had suffered a depressive episode in the preceding month. There was a higher proportion of women with depression in both of the periods. More than 50% of the episodes were moderate, in both men and women. There were higher prevalences of depression in persons older than 45 years. The factors associated with depression in the preceding month were: female gender; considering one's health to be moderate or bad; suffering from pain or discomfort; having difficulties in interpersonal relations; consuming marijuana, addictive substances, stimulants, or tranquilizers; being dependent on alcohol; and being unemployed and unable to work. CONCLUSIONS: Depression is a frequent disorder in Colombia. Measures directed at reducing the risk of depression should be implemented, especially among women and in persons over 45 years old.

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Preliminary pharmacobiological study of new steroidal sapogenins

González, A. G.; Darias, V.; Suárez, M. C.; Janssen, K.
1983-01-01

Digital.CSIC (Spain)