Sample records for CORRELACION DE ESTRUCTURA-ACTIVIDAD (structure-activity relationships)
from WorldWideScience.org

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1

Técnicas empleadas para el estudio de la interacción entre agentes antitumorales y el DNA

García, M. A.; Pascual-Teresa, B. de
2004-02-01

Resumen en español Los procesos oncológicos se caracterizan por un aumento incontrolado de la proliferación celular y en ellos está implicada la molécula de DNA. El DNA es la diana biológica con la que interaccionan muchos de los fármacos antitumorales y diversos compuestos potencialmente antineoplásicos. Tras muchos años de trabajo, los investigadores han sido capaces de diseñar y sintetizar numerosos compuestos que se unen al DNA por diferentes mecanismos y entre ellos se encuent (mas) ran muchos de los agentes antitumorales conocidos. Diversas técnicas nos permiten hoy en día establecer los tipos de interacciones que tienen lugar entre los ligandos y el DNA, algunas de ellas son ya clásicas y otras, sin embargo, son de reciente desarrollo. Una combinación racional de métodos puede ayudar a determinar el mecanismo molecular de la unión, a establecer relaciones estructura-actividad y, lo que es más importante, a diseñar de forma racional nuevos agentes. Resumen en inglés Oncological processes are characterized by an uncontrolled cell replication always associated to DNA implication. DNA molecule is the biological target for the action of many antitumor drugs and potential antineoplastic compounds. As a result of many years of work, researchers have been able to design and synthesize a great number of compounds binding to DNA through different mechanisms, among which many known antitumor agents are found. Several techniques allow us nowada (mas) ys to establish the type of interactions between DNA and its ligands, some classical and some recently developed. A reasoned combination of methods can help to differentiate the molecular mechanisms of the binding processes, to establish the structure-activity relationships, and, what is more important, to develop reasoned designs for the discovery of new agents.

Scientific Electronic Library Online (Spanish)

2

9-Arylpurines as a Novel Class of Enterovirus Inhibitors

Aguado, Leire; Thibaut, Hendrik Jan; Priego, Eva M.; Jimeno, M. Luisa; Camarasa, Mª Jose; Neyts, Johan; Pérez Pérez, Mª Jesus
2010-01-01

Digital.CSIC (Spain)

4

Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans. Part 2: Effect of side chain homologation

Carrillo Fumero, Romen; León, Leticia G.; Martín, Tomás; Martín, Víctor S.; Padrón, José M.
2007-02-01

Digital.CSIC (Spain)

5

Studies on structure-activity relationships of the neuroprotective tripeptide H-Gly-Pro-Glu-OH (GPE)

Alonso De Diego, Sergio A; Gutierrez-Rodriguez, M.; González-Muñiz, Rosario; Herranz, Rosario; Jimeno, M. Luisa; Cenarruzabeitia, Edurne; Frechilla, Diana; Del Río, Joaquin; García-López, M. Teresa
2005-01-01

Digital.CSIC (Spain)

6

Structural diversity and defensive properties of norditerpenoid alkaloids

González-Coloma, Azucena; Reina, Matías; Medinaveitia, Alberto; Guadaño, Ana; Santana, Omar; Martínez-Díaz, Rafael

16 pages, 4 figures, 1 table.-- PMID: 15503527 [PubMed]. | We have tested the insect antifeedant and toxic activity of 43 norditerpenoid alkaloids on Spodoptera littoralis and Leptinotarsa decemlineata including eserine (physostigmine), anabasine, and atropine. Antifeedant effects of the test compou...

DRIVER (Spanish)

7

Structural diversity and defensive properties of norditerpenoid alkaloids

González-Coloma, Azucena; Reina, Matías; Medinaveitia, Alberto; Guadaño, Ana; Santana, Omar; Martínez Díaz, Rafael; Ruiz-Mesía, Lastenia; Alva, Allenger; Grandez, Maritza; Díaz, Rafael; Gavín, José A.; Fuente, Gabriel de la
2004-07-01

Digital.CSIC (Spain)

8

Structural diversity and defensive properties of diterpenoid alkaloids

Reina, Matías; González-Coloma, Azucena

15 pages, 7 figures, 8 tables.-- Printed version published Apr 2007. | Diterpenoid alkaloids are compounds of pharmacological interest. Forty four C19 norditerpenoid (NDAs) and 23 C20 diterpenoid (DAs) alkaloids isolated from Aconitum, Delphinium and Consolida species were tested for their insectici...

DRIVER (Spanish)

10

Samarium(II) promoted stereoselective synthesis of antiproliferative cis-β-alkoxy-γ-alkyl-γ-lactones

Donadel, Osvaldo J.; Martín, Tomás; Martín, Víctor S.; Padrón, José M.
2007-01-01

Digital.CSIC (Spain)

11

Propiedades microbiológicas, clasificación y relación estructura-actividad de cefalosporinas e importancia de las cefalosporinas de cuarta generación/ MICROBIOLOGICAL PROPERTIES, CLASSIFICATIONS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF CEPHALOSPORINS AND THE IMPORTANCE OF FOURTH GENERATION CEPHALOSPORINS

MELLA M, SERGIO; ZEMELMAN M, CLAUDIA; BELLO T, HELIA; DOMINGUEZ Y, MARIANA; GONZALEZ R, GERARDO; ZEMELMAN Z, RAUL
2001-01-01

Resumen en español Las cefalosporinas son uno de los grupos de mayor importancia dentro de los ß-lactámicos. Existen diversas clasificaciones de estas moléculas, siendo la más utilizada aquella que agrupa a estos compuestos de acuerdo a propiedades estructurales, microbiológicas y desarrollo histórico: primera a cuarta generación. Las cefalosporinas de tercera generación han sido ampliamente utilizadas, pero la emergencia de resistencia bacteriana fundamentalmente derivada de la pro (mas) ducción de ß-lactamasas tanto cromosomales como plasmidiales, ha limitado el uso de estos compuestos. Las cefalosporinas de cuarta generación se caracterizan por la presencia de un nitrógeno cuaternario en C3, además de mantener el grupo metoxi-imino aminotiazolil en C7. Presentan una elevada penetración intracelular a través de la membrana externa de bacilos Gram negativos y tienen una baja afinidad por enzimas que degradan cefalos-porinas de tercera generación. Cefepime, una cefalosporina de cuarta generación, demostró una mayor actividad inhibitoria sobre cepas chilenas de Klebsiella pneumoniae y Escherichia coli productoras de ß-lactamasas de espectro extendido, que cefotaxima y ceftazidima Resumen en inglés The cephalosporins are one of the most important types of ß-lactam antibiotics. There are various classifications of these molecules, but the most frecuently used classifies them according to their structures, microbiological properties and historical development: first to fourth generation cephalosporins. Third generation cephalosporins have been extensively used, but the emergence of bacterial resistance, mainly as a consecuence of chromosomal and plasmidial production (mas) of ß-lactamases has limited the use of these antibiotics. Fourth generation cephalosporins are characterized by the presence of a cuaternary nitrogen in C3; mantaining the methoxyimino aminothiazolyl in C7. Fourth generation cephalosporins display a high capacity of intracellular penetration through the external membranes of Gram negative rods and a low affinity to enzymes that degrade third generation cephalosporins. Cefepime, a fourth generation cephalosporin, has shown more inhibitory activity against chilean strains of Klebsiella pneumoniae and Escherichia coli that produce extended-spectrum ß-lactamases, than cefotaxime and ceftazidime

Scientific Electronic Library Online (Spanish)

12

Procyanidins from pine bark: Relationships between structure, composition and antiradical activity

Jerez, María; Touriño, Sonia; Sineiro, Jorge; Torres, Josep Lluís; Núñez, María José

DRIVER (Spanish)

13

New aminocyclitols as modulators of glucosylceramide metabolism

Egido-Gabás, Meritxell; Serrano, Pedro; Casas Brugulat, Josefina; Llebaria Soldevilla, Amadeu; Delgado Cirilo, Antonio
2005-03-01

Digital.CSIC (Spain)

14

Natural insecticides: Structure diversity, effects and structure-activity relationships. A case study

González-Coloma, Azucena; Reina, Matías; Gutiérrez, Carmen; Fraga, Braulio M.

31 pages.-- Issue title: "Bioactive Natural Products". | For the past ten years our research group has been working on bioactive natural products with insecticidal effects. We have focused mainly on the flora of the Canarian Archipelago because of its rich biodiversity (Lauraceae, Compositae, Boragi...

DRIVER (Spanish)

15

Natural insecticides: Structure diversity, effects and structure-activity relationships. A case study

González-Coloma, Azucena; Reina, Matías; Gutiérrez, Carmen; Fraga, Braulio M.
2002-01-01

Digital.CSIC (Spain)

16

Liquid crystalline and nonlinear optical properties of bent-shaped compounds derived from 3,49-biphenylene.

Pintre, Inmaculada C.; Gimeno, Nélida; Serrano, José Luis; Ros, M. Blanca; Alonso, I.; Folcia, César L.; Ortega, Josu; Etxebarria, Jesús
2007-02-14

Digital.CSIC (Spain)

17

Insect antifeedant ryanodane diterpenes from Persea indica

González-Coloma, Azucena; Terrero, David; Perales, Áurea; Escoubas, Pierre; Fraga, Braulio M.
1996-01-01

Digital.CSIC (Spain)

19

Hybrid molecules containing benzo[4,5]imidazo[1,2-d][1,2,4]thiadiazole and α-bromoacryloyl moieties as potent apoptosis inducers on human myeloid leukaemia cells

Romagnoli, Romeo; Baraldi, Pier Giovanni; Carrión, María Dora; Cruz-López, Olga; Preti, Delia; Tabrizi, Mojgan Aghazadeh; Fruttarolo, Francesca; Heilmann, Jörg; Bermejo, Jaime; Estévez, Francisco
2007-02-25

Digital.CSIC (Spain)

20

HIV-1 specific reverse transcriptase inhibitors: Why are TSAO-nucleosides so unique?

Camarasa, Mª José; San-Felix, Alejandra; Perez-Perez, María Jesús; Velazquez, Sonsoles; Alvarez, Rosa; Chamorro, Cristina; Jimeno, M. Luisa; Perez, Carlos; Gago, Federico; De Clercq, Erik; Balzarini, Jan
2000-01-01

Digital.CSIC (Spain)

21

Evaluating the interactions of vertebrate receptors with persistent pollutants and antifouling pesticides using recombinant yeast assays

Noguerol Risco, Tania Noelia; Boronat Llop, Susanna; Casado Belloso, Marta; Raldúa, Demetrio; Barceló, Damià; Piña, Benjamín
2006-06-01

Digital.CSIC (Spain)

22
23

Comparative antioxidant and cytotoxic effect of procyanidin fractions from grape and pine

Ugartondo, Vanessa; Mitjans, Montserrat; Touriño, Sonia; Torres, Josep Lluís; Vinardell, M. Pilar
2007-09-08

Digital.CSIC (Spain)

24

Children's Gestures from 18 to 30 months

Andrén, Mats

This thesis concerns the nature of the gestures performed by five Swedish children. The children are followed from 18 to 30 months of age: an age range which is characterized by a rapid succession of developmental changes in children's abilities to communicate by means of both spoken language and ge...

DRIVER (Spanish)

25

Chemical tools to investigate sphingolipid metabolism and functions

Delgado Cirilo, Antonio; Casas Brugulat, Josefina; Llebaria Soldevilla, Amadeu; Abad, José Luis; Fabriàs, Gemma
2007-06-25

Digital.CSIC (Spain)

26

Bioactive eremophilanolides from Senecio poepigii

Reina, Matías; González-Coloma, Azucena; Domínguez-Díaz, Dulce; Cabrera, Raimundo; Giménez Mariño, Cristina

7 pages, 2 figures, 3 tables.-- PMID: 16286302 [PubMed]. | A new bioactive eremophilanolide, 1α-tigloyloxy-8βH,10βH-eremophil-7(11)-en-8α,12-olide (1), was isolated from Senecio poepigii and its structure was elucidated by spectral analysis. 1α-Angeloyloxy-8β-methoxy-10βH-eremophil-7(11)-en-8α,12-ol...

DRIVER (Spanish)

27

Bioactive eremophilanolides from Senecio poepigii

Reina, Matías; González-Coloma, Azucena; Domínguez-Díaz, Dulce; Cabrera, Raimundo; Giménez Mariño, Cristina; Rodríguez, Matías L.; Villarroel, Luis
2006-01-01

Digital.CSIC (Spain)

28

Antiproliferative activity in HL60 cells by tetrasubstituted pyrroles: a structure-activity relationship study

Padrón, José M.; Tejedor, David; Santos-Expósito, Alicia; García-Tellado, Fernando; Martín, Víctor S.; Villar, Jesús
2005-04-12

Digital.CSIC (Spain)

29

Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure–activity relationships

Alonso De Diego, Sergio A.; Muñoz, Pilar; González-Muñiz, Rosario; Cenarruzabeitia, Edurne; Frechilla, Diana; Del Río, Joaquín; Jimeno, M. Luisa; García-López, M. Teresa
2005-03-03

Digital.CSIC (Spain)

30

Analogs of the dihydroceramide desaturase inhibitor GT11 modified at the amide function: synthesis and biological activities

Bedia Girbés, Carmen; Triola Guillem, Gemma; Casas Brugulat, Josefina; Llebaria Soldevilla, Amadeu; Fabriàs, Gemma
2005-09-08

Digital.CSIC (Spain)