Sample records for ESTREPTOZOTOCINA (streptozotocin)
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2

p38δ and PKD1: Kinase Switches for Insulin Secretion

Cuenda, Ana; Nebreda, Angel R.

Incluye 1 figura. | Insufficient production of the hormone insulin by pancreatic β cells results in diabetes. In this issue, Sumara et al. (2009) report key roles for the protein kinases p38δ and PKD1 in the regulation of insulin secretion as well as in the survival of pancreatic β cells. | Peer rev...

DRIVER (Spanish)

3

Type 1 Diabetes in the Spanish Population: additional factors to Class II HLA-DR3 and -DR4

de la Concha, Emilio G; Martínez, Alfonso; Urcelay, Elena; de la Calle, Hermenegildo; Santiago, José L; Méndez, Julián

DRIVER (Spanish)

4

Transplanted long-term cultured pre-BI cells expressing calpastatin are resistant to B cell receptor–induced apoptosis

Ruíz Vela, Antonio; Serrano Gómez, Fernando; González de la Peña, Manuel Angel; Abad, José Luis; Bernad, Antonio; Maki, Masatoshi; Martínez-Alonso, Carlos
2001-08-01

Digital.CSIC (Spain)

5

The markers of inflammation and endothelial dysfunction in correlation with glycated haemoglobin are present in type 2 diabetes mellitus patients but not in their relatives

Gómez, José Manuel; Vila, Ramón; Catalina, Pablo; Soler, Juan; Badimón, Lina; Sahún, Manel

PMID: 18347976.-- Final full-text version of the paper available at: 10.1007/s10719-008-9118-8 or http://www.springerlink.com/content/41v66012055486r0/ | The aim of this study is to test several biomarkers of inflammation, of endothelial dysfunction, glycated haemoglobin, and their reflection in art...

DRIVER (Spanish)

8

TNFalpha-Polymorphismus bei Patienten mit Sepsis und Schilddrüsenkarzinomen

Rossbach, Christiane

Das Zytokin Tumornekrosefaktor a (TNFa) hat einen entscheidenden Anteil an der Entwicklung schwerer Komplikationen, wie septischer Schock und Multiorganversagen nach Entwicklung einer Sepsis. Eine Assoziation des TNF2-Allels mit einem erhöhten TNF a Spiegel und einer höheren Mortalitätsrate wurde i...

DRIVER (Spanish)

9

Susceptibility to type 1 diabetes conferred by the PTPN22 C1858T polymorphism in the Spanish population

Fernández-Arquero, Miguel; Santiago, Jose Luis; de la Calle, Hermenegildo; Martínez, Alfonso; Figueredo, M Ángeles

DRIVER (Spanish)

11

S6K1 deficiency protects against apoptosis in hepatocytes

González-Rodríguez, Águeda; Alba, Javier; Zimmerman, Valeri; Kozma, Sara C.; Martínez Valverde, Ángela
2009-02-18

Digital.CSIC (Spain)

12

Ras-GRF1 signaling is required for normal β-cell development and glucose homeostasis

Font de Mora, Jaime; Esteban, Luis Miguel; Burks, Deborah J.; Núñez, Alejandro; Garcés, Carmen; García-Barrado, María José

Final full-text version of the paper available at: http://www.nature.com/emboj/journal/v22/n12/index.html | Development of diabetes generally reflects an inadequate mass of insulin-producing β-cells. β-cell proliferation and differentiation are regulated by a variety of growth factors and hormones, ...

DRIVER (Spanish)

13

Ras-GRF1 signaling is required for normal β-cell development and glucose homeostasis

Font de Mora, Jaime; Esteban, Luis Miguel; Burks, Deborah J.; Núñez, Alejandro; Garcés, Carmen; García-Barrado, María José; Iglesias-Osma, María Carmen; Moratinos, Julio; Ward, Jerrold M.; Santos de Dios, Eugenio
2003-06-01

Digital.CSIC (Spain)

14

Procedimiento quimioenzimático para la preparación de iminociclitoles.

Clapés Saborit, Pere; Joglar Tamargo, Jesús; Castillo Expósito, José A.; Lozano Pérez, Carles
2010-05-27

Digital.CSIC (Spain)

15

Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice

González-Navarro, Herminia; Vila-Caballer, Marian; Pastor, María Francisca; Vinué, Angela; White, Morris F.

This is an, un-copyedited, author manuscript that has been accepted for publication in the Frontiers in Bioscience | Atherosclerosis is increased in type 2 diabetic patients but the precise mechanisms underlying this predisposition remain vague. Mice deficient for insulin receptor substrate 2 (IRS2)...

DRIVER (Spanish)

16

Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice

González-Navarro, Herminia; Vila-Caballer, Marian; Pastor, María Francisca; Vinué, Ángela; White, Morris F.; Burks, Deborah J.; Andrés, Vicente
2007-01-01

Digital.CSIC (Spain)

17

Pathophysiology of the proatherothrombotic state in the metabolic syndrome

Palomo, Ivan; Moore-Carrasco, Rodrigo; Alarcón, Marcelo; Rojas, Armando; Espana, Francisco; Andrés, Vicente; González-Navarro, Herminia
2010-01-01

Digital.CSIC (Spain)

19

PTP1B deficiency increases glucose uptake in neonatal hepatocytes: involvement of IRA/GLUT2 complexes

González-Rodríguez, Águeda; Nevado, Carmen; Escrivá, Fernando; Sesti, Giorgio; Rondinone, Cristina M.; Benito, Manuel; Valverde, Ángela M.
2008-08-01

Digital.CSIC (Spain)

21

Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice

Gómez-Sintes, Raquel; Hernández, Félix; Bortolozzi, Analía; Artigas, Francesc; Avila, Jesús; Zaratin, Paola; Gotteland, Jean Pierre; Lucas, José J.
2007-06-06

Digital.CSIC (Spain)

24

MiRNA Expression Profile of Human Subcutaneous Adipose and during Adipocyte Differentiation

Ortega Delgado, Francisco J.; Moreno-Navarrete, José M.; Pardo, Gerard; Sabater, Mónica; Hummel, Manuela; Ferrer, Anna; Rodríguez-Hermosa, José I.; Ricart, Wifredo; Peral, Belén; Fernández Real, José Manuel
2010-02-02

Digital.CSIC (Spain)

25

Maternal nonthyroidal illness and fetal thyroid hormone status, as studied in the streptozotocin-induced diabetes mellitus rat model

Calvo, Rosa M.; Morreale de Escobar, Gabriella; Escobar del Rey, Francisco; Obregón, María Jesús
1997-03-01

Digital.CSIC (Spain)

27

Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice

González-Rodríguez, Águeda; Mas Gutiérrez, José Antonio; Sanz-González, Silvia; Ros, Manuel; Burks, Deborah J.; Valverde, Ángela M.
2009-11-22

Digital.CSIC (Spain)

28

Inhibidores heterocíclicos del glicógeno sintasa quinasa GSK-3

Martínez Gil, Ana; Castro Morera, Ana; Pérez Martín, María Concepción; Alonso Cascón, Mercedes; Dorronsoro Díaz, Isabel

Traducción de Patente Europea E01928117 (fecha de solicitud, 11/05/2001).-- Prioridad: 11.05.2000 ES 200001185, 12.12.2000 GB 0030284.-- Titulares: Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM). | La presente invención se refiere a inhibidores heterocíc...

DRIVER (Spanish)

29

Inhibidores heterocíclicos del glicógeno sintasa quinasa GSK-3

Martínez Gil, Ana; Castro Morera, Ana; Pérez Martín, María Concepción; Alonso Cascón, Mercedes; Dorronsoro Díaz, Isabel; Moreno Muñoz, Francisco José; Wandosell Jurado, Francisco
2008-02-01

Digital.CSIC (Spain)

30

Inhibidores heterocíclicos del enzima GSK 3 útiles en el tratamiento de procesos neurodegenerativos e hiperproliferativos

Pérez Martín, María Concepción; Moreno Muñoz, Francisco José; Martínez Gil, Ana; Castro Morera, Ana

DRIVER (Spanish)

31

Inhibidores heterocíclicos del enzima GSK 3 útiles en el tratamiento de procesos neurodegenerativos e hiperproliferativos

Pérez Martín, María Concepción; Moreno Muñoz, Francisco José; Martínez Gil, Ana; Castro Morera, Ana; Wandosell Jurado, Francisco
2003-09-16

Digital.CSIC (Spain)

32

Increased tissue factor, MMP-8, and D-dimer expression in diabetic patients with unstable advanced carotid atherosclerosis

Krupinski, Jerzy; Turu, Marta M.; Font, M.ª Angels; Ahmed, Nesser; Sullivan, Matthew; Luque, Ana; Rubio, Francisco

DRIVER (Spanish)

33

Increased tissue factor, MMP-8, and D-dimer expression in diabetic patients with unstable advanced carotid atherosclerosis

Krupinski, Jerzy; Turu, Marta M.; Font, M.ª Angels; Ahmed, Nesser; Sullivan, Matthew; Luque, Ana; Rubio, Francisco; Badimón, Lina; Slevin, Mark
2007-08-01

Digital.CSIC (Spain)

34

Improved resolution of the human adipose tissue proteome at alkaline and wide range pH by the addition of hydroxyethyl disulfide

Cortón, Marta; Villuendas, Gemma; Botella-Carretero, José I.; San Millán, José I.; Escobar-Morreale, Héctor F.; Peral, Belén
2004-02-01

Digital.CSIC (Spain)

35

Heterocyclic inhibitors of glycogen synthase kinase GSK-3

Wandosell Jurado, Francisco; Martínez Gil, Alejandrona; Pérez Martín, María Concepción; Dorronsoro Díaz, Isabel; Alonso, Mercedes; Castro Morera, Ana; Moreno Muñoz, Francisco José
2006-03-16

Digital.CSIC (Spain)

36

Heterocyclic inhibitors of glycogen synthase kinase GSK-3

Martínez García, Ana; Castro Morera, Ana; Pérez Martín, María Concepción; Alonso, Mercedes; Dorronsoro Díaz, Isabel; Moreno Muñoz, Francisco José; Wandosell Jurado, Francisco
2001-11-15

Digital.CSIC (Spain)

37

Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus

Radstake, Timothy R. D. J.; Gorlova, Olga; Rueda, B.; Martín, Jose Ezequiel; Alizadeh, Behrooz Z.; Palomino-Morales, Rogelio; Coenen, Marieke J.; Vonk, Madelon C.; Voskuyl, Alexandre E.; Scheurwegh, Annemie J.; Broen, Jasper C.; van Riel, Piet L. C. M.; van 't Slot, Ruben; Italiaander, Annet; Ophoff, Roel A.; Riemekasten, Gabriela; Hunzelmann, Nico; Simeón, Carmen P.; Ortego-Centeno, Norberto; González-Gay, Miguel A.; González-Escribano, María Francisca; Airo, Paolo; van Laar, Jaap; Herrick, Ariane
2010-04-11

Digital.CSIC (Spain)

39

Functional Study of a Novel Single Deletion in the TITF1/NKX2.1 Homeobox Gene That Produces Congenital Hypothyroidism and Benign Chorea But Not Pulmonary Distress

Moya, Christian M.; Nanclares, Guiomar Perez; Castaño, Luis; Potau, Neus; Bilbao, J. Ramón; Carrascosa, Antonio; Bargadá, María; Coya, Raquel; Martul, Pedro; Vicens-Calvet, Enric; Santisteban, Pilar
2006-05-01

Digital.CSIC (Spain)

43

Enzyme inhibitors

Martínez Gil, Ana; Castro Morera, Ana; Martín Perez, María Concepción; Alonso Cascón, Mercedes; Dorronsoro Díaz, Isabel; Moreno Muñoz, Francisco José; Wandosell Jurado, Francisco
2003-10-16

Digital.CSIC (Spain)

46

Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stability

Galán, María; Vincent, Olivier; Roncero, Isabel; Azriel, Sharona; Boix-Pallares, Pedro; Delgado-Álvarez, Elías; Díaz-Cadórniga, Fernando; Blázquez, Enrique; Navas, M. Ángeles
2006-01-01

Digital.CSIC (Spain)

47

Differential Proteomics of Omental and Subcutaneous Adipose Tissue Reflects Their Unalike Biochemical and Metabolic Properties

Pérez Pérez, Rafael; Ortega Delgado, Francisco J.; García Santos, Eva; López, Juan A.; Camafeita, Emilio; Ricart, Wifredo; Fernández Real, José Manuel; Peral, Belén
2009-02-09

Digital.CSIC (Spain)

48

Diabetes-specific family conflict and well-being in parents of adolescents with diabetes: a Dutch-Spanish comparison

Beléndez Vázquez, Marina; De Wit, Maartje; Snoek, Frank J.; Marín, María del Carmen

DRIVER (Spanish)

50

Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes

González-Rodríguez, Águeda; Clampit, Jill E.; Escribano, Óscar; Benito, Manuel; Rondinone, Cristina M.; Valverde, Ángela M.
2007-02-01

Digital.CSIC (Spain)

52

Caracterización Fitoquímica y Efecto Hipoglucemiante de Tecoma stans y su Relación con la Presencia del Cromo como Factor de Tolerancia a la Glucosa/ Phytochemical Characterization and Hypoglycemic Effect of the Tecoma stans and its Relationship to the Presence of Chromium as a Factor for Glucose Tolerance

Ibarra, Ma. de J; Cantú, Pedro C; Verde, María J; Oranday, Azucena
2009-01-01

Resumen en español Se realizó la caracterización fitoquímica y la determinación del cromo en hojas de Tecoma stans, observando su efecto hipoglucemiante en animales con diabetes mellitus inducida en forma experimental. Como hiperglucemiante se utilizó estreptozotocina en ratas machos Sprague-Dawley a una dosis de 45 mg/kg de peso. Los tratamientos experimentales, todos por vía oral, fueron los siguientes para grupos diabéticos y grupos no diabéticos: agua, infusión de la planta, pi (mas) colinato de cromo, e infusión combinada con picolinato de cromo. Se encontró cromo en T. stans (54 µg/100g), la hiperglucemia disminuyó hasta 33.5 % con T. stans, 10.1% con picolinato de cromo y 32.3% con la combinación de T. stans y picolinato de cromo, en 45 días. Con este estudio se confirma el efecto hipoglucemiante de T. stans Resumen en inglés Phytochemical characterization of Tecoma stans leaves, determination of chromium and their hypoglucemiant action in experimental animals with induced diabetes was done. The hyperglucemiant streptozotocin was employed in Sprague Dawley male rats at a dose of 45 mg/kg. The experimental treatments, all orally delivered, were the following for both diabetic and non diabetic groups: water, infusion of the plant, chromium picolinate and infusion combined with chromium picolinat (mas) o. Chromium was found in T. stans (54 µg/100g), glucose levels decreased up to 33, 5 % with T. stans, 10, 1% with chromium picolinate and 32, 3% with the combination of T. stans and chromium picolinate, in 45 days. The hypoglucemiant effect of T. stans was confirmed with this study

Scientific Electronic Library Online (Spanish)

53

CR-6 protects glutathione peroxidase activity in experimental diabetes

Miranda, María; Muriach, María; Almansa, Inmaculada; Arnal, Emma; Messeguer Peypoch, Àngel; Díaz-LLopis, Manuel

5 pages, 3 figures.-- PMID: 17964420 [PubMed].-- Printed version published on Dec 2007. | Antioxidants can be useful as a supportive therapy in diabetes, and we try to elucidate some of the mechanisms by which these compounds are able to protect from diabetic complications. For this purpose we have ...

DRIVER (Spanish)

54

CR-6 protects glutathione peroxidase activity in experimental diabetes

Miranda, María; Muriach, María; Almansa, Inmaculada; Arnal, Emma; Messeguer Peypoch, Àngel; Díaz-LLopis, Manuel; Romero, Francisco. J.; Bosch Morell, Francisco
2007-08-14

Digital.CSIC (Spain)

55

CARACTERIZACIÓN DEL ESTRÉS OXIDATIVO EN RATAS WISTAR DIABÉTICAS POR ESTREPTOZOTOCINA/ OXIDATIVE STRESS CARACTERIZATION IN STREPTOZOTOCIN-DIABETIC WISTAR RATS

MORA H, Ángela C; ARAGÓN N, Diana M; OSPINA G, Luis F
2009-09-01

Resumen en español La diabetes es un trastorno metabólico crónico de gran alcance epidemiológico. Numerosos estudios han demostrado que la diabetes mellitus se encuentra asociada al incremento de la formación de radicales libres derivados del oxígeno y a la disminución del potencial antioxidante del organismo, generando el daño oxidativo de algunos componentes de la célula tales como las proteínas, carbohidratos, lípidos y ácidos nucleicos. Este trabajo pretende establecer, en ra (mas) tas Wistar, la relación dosis-respuesta de estreptozotocina frente a los niveles de glucosa y a diferentes parámetros del estatus antioxidante. Como marcadores del daño asociado a las especies de oxígeno reactivas se evaluó la actividad enzimática de catalasa y de superóxido dismutasa, la capacidad antioxidante total del plasma y la peroxidación lipídica. Los resultados obtenidos evidencian una clara relación de la dosis de estreptozotocina con los niveles de glucosa y los parámetros de estrés oxidativo evaluados luego de 20 días de la inducción de la diabetes experimental. Resumen en inglés Diabetes is a chronic metabolic disease. Numerous studies have demonstrated that diabetes mellitus is associated to free radicals increase derived from oxygen and to the organism potential antioxidant decrease generating oxidative damage of some cell components like proteins, nucleic acids, carbohydrates and lipids. After 20 days of administration of streptozotocin in Wistar rats, we have found a relationship between levels of blood glucose and some markers from antioxida (mas) nt status. We evaluate oxidative stress markers like catalasa and superoxide dismutase acivities, ferric reducing ability of plasma and thiobarbituric acid reactive species.

Scientific Electronic Library Online (Spanish)

56

Beliefs about insulin as a predictor of fear of hypoglycaemia

Beléndez Vázquez, Marina; Hernández Mijares, Antonio

The present study extends previous research by exploring the predictive value of beliefs about insulin therapy in fear of hypoglycaemia (FoH). Data were collected on 81 Spanish adults (aged 18–58 years) with type 1 diabetes. Participants completed a survey questionnaire containing the following meas...

DRIVER (Spanish)

57

Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity

San Millán, José L.; Cortón, Marta; Villuendas, Gemma; Sancho, José; Peral, Belén; Escobar-Morreale, Héctor F.
2004-06-01

Digital.CSIC (Spain)

59

Aplicaciones clínicas del biomagnetismo

Madroñero de la Cal, Antonio
2003-01-01

Digital.CSIC (Spain)

60

An oily fish increses insulin sensitivity compared to a red meat diet in young iron-deficient women

Navas-Carretero, S.; Pérez-Granados, Ana María; Schoppen, Stefanie; Vaquero, M. P.
2011-02-25

Digital.CSIC (Spain)

61
62

A rare missense mutation in a type 2 diabetes patient decreases the transcriptional activity of human sterol regulatory element binding protein-1

Vernia, Santiago; Eberlé, Delphine; Hernández Mijares, Antonio; Foufelle, Fabienne; Casado, Marta
2006-02-20

Digital.CSIC (Spain)

63

A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice

Riquelme Galiana, Raquel; Cediel Algovia, Rafael; Contreras, Julio; Rodríguez de la Rosa, Lourdes; Murillo Cuesta, Silvia; Hernández Sánchez, Catalina; Zubeldia Ortuño, José Miguel; Cerdán García-Esteller, Sebastián; Varela Nieto, Isabel
2010-07-13

Digital.CSIC (Spain)