Sample records for ROTURAS DE FILAMENTOS (strand breaks)
from WorldWideScience.org

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2

The Drosophila spn-D gene encodes a RAD51C-like protein that is required exclusively during meiosis

Abdu, Uri; González-Reyes, Acaimo; Ghabrial, Amin; Schüpbach, Trudi

Sequence data from this article have been deposited with the Gen-Bank data libraries under accession no. AY257540. | In Drosophila, mutations in double-strand DNA break (DSB) repair enzymes, such as spn-B, activate a meiotic checkpoint leading to dorsal-ventral patterning defects in the egg and an a...

DRIVER (Spanish)

3

The Drosophila spn-D gene encodes a RAD51C-like protein that is required exclusively during meiosis

Abdu, Uri; González-Reyes, Acaimo; Ghabrial, Amin; Schüpbach, Trudi
2003-09-01

Digital.CSIC (Spain)

4

Sequential Loading of Cohesin Subunits during the First Meiotic Prophase of Grasshoppers

Valdeolmillos, Ana M.; Viera, Alberto; Page, Jesús; Prieto, Ignacio; Santos, Juan L.; Parra, María Teresa; Heck, Margarete M. S.; Martínez-Alonso, Carlos; Barbero, José Luis; Suja, José A.; Rufas, Julio S.
2007-02-23

Digital.CSIC (Spain)

5

SMC proteins, new players in the maintenance of genomic stability

Cortés-Ledesma, Felipe; Piccoli, Giaccomo de; Haber, James E.; Aragón, Luis; Aguilera, Andrés
2007-04-15

Digital.CSIC (Spain)

6

Overexpression of human DNA polymerase µ (Pol µ) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate

Ruiz, José F.; Lucas, Daniel; García-Palomero, Esther; Saez, Ana I.; González, Manuel A.; Piris, Miguel A.; Bernad, Antonio; Blanco, Luis
2004-11-01

Digital.CSIC (Spain)

7

Nucleoporins Prevent DNA Damage Accumulation by Modulating Ulp1-dependent Sumoylation Processes

Palancade, Benoit; Xianpeng, Liu; García-Rubio, María L.; Aguilera, Andrés; Xiaolan, Zhao; Doye, Valérie
2007-08-01

Digital.CSIC (Spain)

8

Lack of sugar discrimination by human Pol µ requires a single glycine residue

Ruiz, José F.; Juárez, Raquel; García-Díaz, Miguel; Terrados, Gloria; Picher, Angel J.; González-Barrera, Sergio

DNA polymerase mu (Pol µ) is a novel family X DNA polymerase that has been suggested to play a role in micro-homology mediated joining and repair of double strand breaks. We show here that human Pol µ is not able to discriminate against the 2'-OH group of the sugar moiety. It inserts rNTPs with an e...

DRIVER (Spanish)

9

Lack of sugar discrimination by human Pol µ requires a single glycine residue

Ruiz, José F.; Juárez, Raquel; García, Miguel Ángel; Terrados, Gloria; Picher, Ángel J.; González-Barrera, Sergio; Fernández de Henestrosa, Antonio; Blanco, Luis
2003-01-01

Digital.CSIC (Spain)

10

Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition

Aguilar-Quesada, Rocío; Muñoz-Gámez, José A.; Martín-Oliva, David; Peralta, Andreína; Valenzuela, María Teresa; Matínez-Romero, Rubén; Quiles-Pérez, Rosa; Menissier-de Murcia, Josiane; Murcia, Gilbert de; Ruiz de Almodóvar, José Mariano; Oliver, Francisco Javier
2007-04-25

Digital.CSIC (Spain)

11

Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase

Romero, Francisco; Multon, Marie-Christine; Ramos-Morales, Francisco; Domínguez, África; Bernal, Juan A.; Pintor-Toro, José A.; Tortolero, María
2001-01-01

Digital.CSIC (Spain)

13

Growth hormone protects against radiotherapy-induced cell death

Madrid, Olga; Varea, Silvia; Sánchez Pérez, Isabel; Gómez-García, Lourdes; Miguel, Enrique de; Gómez de Segura, Ignacio A.; Perona Abellán, Rosario
2000-10-01

Digital.CSIC (Spain)

14

Exploración del efecto protector frente a radicales libres de derivados de la uva (Vitis vinifera L. Cv. Tannat) en Saccharomyces cerevisiae/ Analysis of a putative protection against free radicals by grape derivatives (Vitis vinifera L. Cv. Tannat) in Saccharomyces cerevisiae

Bracesco, N.; Salvo, V. A.; Rocha, S.; Dell, M.; Carrau, F.; Nunes, E.
2007-03-01

Resumen en español Se exploró un posible efecto protector del genoma por parte de un derivado de la uva (vino Tannat). Se utilizaron poblaciones celulares haploides y diploides de Saccharomyces cerevisiae como modelo eucariota. Muestras celulares se expusieron a H2O2 en medio nutriente. El ADN se analizó por densitometría láser, luego de su aislamiento y separación por electroforesis con campos pulsados. Se aplicó la distribución de Poisson para la determinación de roturas dobles. E (mas) l número de roturas dobles del ADN y la frecuencia mutagénica aumentaron en función de la dosis de H2O2, disminuyendo la probabilidad de sobrevida. La combinación de H2O2 con vino Tannat aumentó significa-tivamente la probabilidad de sobrevida y disminuyó el número de roturas dobles. No se observó efecto mutagénico por el vino Tannat. Estos efectos pudieron simularse utilizando altas concentraciones de α-tocoferol. Los resultados indican que un derivado de Vitis vinifera puede, en ciertas condiciones, disminuir las dobles roturas de ADN producidas por el H2O2 e incrementar las probabilidades de sobrevida celular. Los blancos involucrados podrían ser, entre otros, componentes intracelulares de las cascadas redox y/o enzimas de reparación del ADN. Resumen en inglés The aim of this work was to analyse a possible genome protection provided by a grape derivative (Tannat wine) in yeast cell populations exposed to H2O2. Haploid and diploid strains of Saccharomyces cerevisiae were used as eukaryotic model. Cell samples were exposed to H2O2 in a nutrient medium. Chromosomal DNA was analysed after isolation and separation by pulsed field electrophoresis. Double strand breaks were determined by laser densitometry and application of Poisson d (mas) istribution. Both haploid and diploid cells showed H2O2 dose dependent DNA fractionation, as well as an increase of lethal -and mutation- events. Upon combination of the Tannat wine and H2O2 a significant decrease of double strand breaks was observed, in association with an increase in surviving fractions. No mutagenic effect was observed after wine exposure. Part of the observations regarding protective wine effect were simulated by exposure to high concentrations of α-tocopherol. Present results indicate that a grape derivative could act as a genome protector increasing cell survival probabilities. Among others, the involved molecular targets could be components of transduction redox cascades as well as DNA repair enzymes.

Scientific Electronic Library Online (Spanish)

15

Drosophila mus301/spindle-C Encodes a Helicase With an Essential Role in Double-Strand DNA Break Repair and Meiotic Progression

McCaffrey, Ruth; St Johnston, Daniel; González-Reyes, Acaimo

PMCID: PMC1667076 | mus301 was identified independently in two genetic screens, one for mutants hypersensitive to chemical mutagens and another for maternal mutants with eggshell defects. mus301 is required for the proper specification of the oocyte and for progression through meiosis in the Drosoph...

DRIVER (Spanish)

17

Different genetic requirements for repair of replication-born double-strand breaks by sister-chromatid recombination and break-induced replication

Cortés-Ledesma, Felipe; Tous, Cristina; Aguilera, Andrés

PMCID: PMC2095809 | Homologous recombination (HR) is the major mechanism used to repair double-strand breaks (DSBs) that result from replication, but a study of repair of DSBs specifically induced during S-phase is lacking. Using an inverted-repeat assay in which a DSB is generated by the encounteri...

DRIVER (Spanish)

19

Chromatin assembly controls replication fork stability

Clemente-Ruiz, Marta; Prado, Félix
2009-05-22

Digital.CSIC (Spain)

20

Characterization of two highly similar Rad51 homologs of Physcomitrella patens

Ayora, Silvia; Piruat, José I.; Luna, Rosa; Reiss, Bernd; Russo, Vincenzo E. A.; Aguilera, Andrés; Alonso, Juan Carlos
2002-02-08

Digital.CSIC (Spain)

21

Characterization of a Natural Mutator Variant of Human DNA Polymerase l which Promotes Chromosomal Instability by Compromising NHEJ

Terrados, Gloria; Gapp, Jean-Pascal; Canitrot, Yvan; García, Miguel Ángel; Bebenek, Katarzyna; Kirchhoff, Tomas; Villanueva, Alberto; Boudsocq, François; Bergoglio, Valerie; Cazaux, Christophe; Kunkel, Thomas A.; Hoffmann, Jean-Sebastien; Blanco, Luis
2009-06-10

Digital.CSIC (Spain)

22

Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle

Alonso Guerrero, Astrid; Cano Gamero, Mercedes; Trachana, Varvara; Fütterer, Agnes; Pacios-Bras, Cristina; Panadero Díaz-Concha, Nuria; Cigudosa, Juan Cruz; Martínez-Alonso, Carlos; Van Wely, Karel H. M.
2010-02-08

Digital.CSIC (Spain)

23

Bacillus subtilis SbcC protein plays an important role in DNA inter-strand cross-link repair

Mascarenhas, Judita; Sánchez, Humberto; Tadesse, Serkalem; Kidane, Dawit; Krisnamurthy, Mahalakshmi; Alonso, Juan Carlos; Graumann, Peter L.
2006-06-16

Digital.CSIC (Spain)

24

Altered Hematopoiesis in Mice Lacking DNA Polymerase μ Is Due to Inefficient Double-Strand Break Repair

Lucas, Daniel; Escudero, Beatriz; Ligos, José Manuel; Segovia, Jose Carlos; Estrada, Juan Camilo; Terrados, Gloria; Blanco, Luis; Samper, Enrique; Bernad, Antonio
2009-02-01

Digital.CSIC (Spain)