Sample records for PIROGENOS (pyrogens)
from WorldWideScience.org

Sample records 1 - 7 shown.



1

Cytotoxin and Pyrogenic Toxin Superantigen Gene Profiles of Staphylococcus aureus Associated with Subclinical Mastitis in Dairy Cows and Relationships with Macrorestriction Genomic Profiles

Fueyo Mendoza, José María; Mendoza, M. Carmen; Rodicio, M. Rosario; Muñiz, J.; Álvarez González, Miguel Ángel; Martín, M. Cruz
2005-03-01

Digital.CSIC (Spain)

2

Ensayo del lisado de amebocitos del Limulus (LAL)

Perdomo Morales, Rolando
2004-04-01

Resumen en inglés En los últimos años, los principales organismos reguladores de productos farmacéuticos (Farmacopeas) exigen cada vez más en sus monografías la aplicación del método del lisado de amebocitos de Limulus (LAL) para la liberación de pirógenos en productos terminados parenterales. El análisis de pirógenos constituye uno de los principales ensayos en el control de calidad de la fabricación de inyectables por su repercusión en la salud humana, puesto que la presenci (mas) a y administración de los mismos, es capaz de provocar una serie de respuestas fisiológicas, en su mayoría de carácter perjudicial y en casos extremos, la muerte del paciente. Por las razones anteriores, existe un creciente interés en el conocimiento y dominio de estos métodos. El presente trabajo muestra una revisión bibliográfica del método del LAL, se tratan aspectos como su descubrimiento y estandarización, aparición en la industria farmacéutica y razones para su triunfo, y los basamentos de los principales métodos o variaciones comerciales del LAL (gelificación, turbidimétricos y cromogénicos) que se describen en las Farmacopeas. During the last years, the main regulating bodies of pharmaceuticals (Pharmacopoeias) have increasingly demanded in their monographies the application of the LAL assay for the release of pyrogens in parenteral finished products. The analysis of pyrogens is one of the fundamental assays in the quality control of the manufacture of injections due to its impact on human health, since their presence and administration may cause a series of physiological responses, which are mostly harmful and, in extreme cases, may produce death. For the above mentioned reasons, there is a rising interest in the throrough knowledge of these methods. The present paper includes a bibliographic review of the LAL method. Aspects such as its discovery and standardization, appearance in the pharmaceutical industry and reasons for its triumph, as well as the foundations of the main methods or commercial variations of LAL (gelification, turbidimetry and chromogenics), which are described in the Pharmacopoeias , are dealt with.

Scientific Electronic Library Online (Spanish)

3

Formulación de una mezcla vitamínica intravenosa para nutrición parenteral total pediátrica/ Intravenous multivitamin formulation for use in pediatric total parenteral nutrition

Carreño G, Patricia; Rosas E, Andrea; Rojas E, Irene
2001-08-01

Resumen en inglés Background: No intravenous multivitamin formulation is available at the Chilean market that fulfills the requirements of pediatric patients on total parenteral nutrition. Therefore, adult formulations must be used. Aim: To prepare a parenteral aqueous multivitamin solution, to be used in pediatric patients. Material and methods: The solution was prepared, mixing vitamins according to their stability and compatibility, in a horizontal laminar flow hood. The quality control (mas) for this formulation at times zero and 30 days consisted of an organoleptic analysis, microbiologic and pyrogen controls and vitamin quantification. In addition, the effect of vitamin solution incorporation on the stability of total parenteral nutrition formulae was evaluated. The approximated production cost was calculated. Results: The ampoules did not show changes on the organoleptic characteristics. No bacterial contamination or pyrogens were detected. Total parenteral nutrition solutions were not modified after the incorporation of the vitamins. The vitamin solution was stable for one month at 4°C. Conclusions: The manufacture of this formulation results in significant savings, because it has a low manufacturing cost and fulfills pediatric requirements (Rev Méd Chile 2001; 129: 905-10)

Scientific Electronic Library Online (Spanish)

4

Soil pollution by PAHs in urban soils: a comparison of three european cities

Morillo González, Esmeralda; Romero, A.S.; Maqueda Porras, Celia; Madrid, Luis; Ajmone-Marsan, F.; Grcman, H.; Davidson, C.M.; Hursthouse, A.S.; Villaverde, J.
2007-07-06

Digital.CSIC (Spain)

5

Relationships between toxin gene content and genetic background in nasal carried isolates of Staphylococcus aureus from Asturias, Spain

Fueyo Mendoza, José María; Mendoza, M. Carmen; Álvarez González, Miguel Ángel; Martín, M. Cruz
2005-02-15

Digital.CSIC (Spain)