Sample records for MUTACIONES NATURALES (natural mutations)
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Sample records 1 - 20 shown. Select sample records:



1

Taninos de diferentes especies vegetales en la prevención del fotoenvejecimiento

González Fresneda, Yulady; Peña Sánchez, Marisol; Sánchez Álvarez, Rosa; Santana, Jorge Luis
2001-03-01

Resumen en español La utilización de algunas sustancias naturales, en específico estructuras polifenólicas como las catequinas oligoméricas y flavonoides, ha demostrado ser una fuente de protección para el organismo. Son reconocidas sus propiedades antimicrobianas, antioxidantes, fotoprotectoras, así como inhibidores de proteasas como la elastasa. Dada la similitud estructural, fueron estudiados los taninos vegetales condensados de diferentes especies forestales a saber: pino, casuari (mas) na, mimosa, conos de pinos, eucalipto y soplillo. En los últimos años se ha prestado especial atención al estudio de nuevas sustancias con características fisicoquímicas capaces de prevenir trastornos que conducen a mutaciones cutáneas provocadas por las radiaciones ultravioletas; por causa fundamentalmente del incremento de la contaminación ambiental y el desgaste de la capa de ozono. El objetivo de este trabajo fue determinar la capacidad fotoprotectora de los taninos y dilucidar su posible mecanismo de acción. Para ello se realizaron 3 técnicas: fotoprotección en bacterias (E. coli); capacidad antioxidante espontánea e inducida en homogenato de cerebro de rata y actividad antielastasa. En los resultados se observó que los taninos de todas las especies vegetales eran capaces de proteger a las bacterias contra el daño de las radiaciones ultravioletas, lo que coincide con una buena actividad antioxidante y antielastasa; resultaron menores estas 2 últimas para el eucalipto Resumen en inglés The use of some natural substances, specifically phenolic structures such as flavonoids and oligomeric catechines has proved to be a source of protection for the body. Their antimicrobial, antioxidant and photoprotective properties are well-known and they are also recognized as protease inhibitors such as elastase. Given their structural similarities, condensed tannins from various vegetal species, such as pine tree, casuarine, mimosa, pine cones, eucalyptus and soplillo (mas) were studied. In the last few years, special attention has been paid to the study of new substances with physical and chemical characteristics, capable of preventing disorders leading to skin mutations resulting from ultraviolet radiations mainly due to the increased environmental pollution and the depletion of the ozone layer. The objective of this paper was to determine the photoprotective capacity and the possible mechanism of action of tannins. To this end, 3 techniques were applied: photoprotection in bacteria (E. coli); spontaneous or induced antioxidant capacity in rat brain homogenate and antielastase activity. The results revealed that tannins from all vegetal species were able to protect bacteria against UV radiation, which coincides with a good antioxidant and antielastase activity. However, eucalyptus showed lower antioxidant and antielastase activity

Scientific Electronic Library Online (Spanish)

2

Use of constrained synthetic amino acids in β-Helix proteins for conformational control

Zanuy, David; Jiménez, Ana I.; Cativiela, Carlos; Nussinov, Ruth; Alemán, Carlos
2007-03-01

Digital.CSIC (Spain)

4

The neglected intrinsic resistome of bacterial pathogens

Fajardo, A.; Martínez-Martín, Nadia; Mercadillo, María; Galán, Juan Carlos; Ghysels, Bart; Matthijs, Sandra; Cornelis, Pierre; Wiehlmann, Lutz; Tümmler, Burkhard; Baquero, Fernando; Martínez, José L.
2008-02-20

Digital.CSIC (Spain)

8

Sunflower seeds with high delta-tocopherol content

Velasco Varo, Leonardo; Fernández Martínez, José María
2009-05-28

Digital.CSIC (Spain)

9

Sistema leptina-melanocortinas en la regulación de la ingesta y el peso corporal/ Leptin-melanocortin system, body weight regulation and obesity

Santos M, José Luis
2009-09-01

Resumen en inglés Obesity is a multifactorial disease that is rarely associated to single gene defects. However, due to their direct cause-effect relationships, those genetic defects that cause some forms of monogenic obesity are relevant in the study of mechanisms that contribute to increased energy intake and body fat accumulation. Most of the genes that have been shown to cause monogenic obesity are related to the leptin-melanocortin system. The functionality of this system has been elu (mas) cidated through natural mutations (Agouti, ob and db) in mice and knock-out models. Mutations related to human monogenic obesity have been described in leptin, leptin receptor, proopiomelanocortin, prohormone convertase 1 or melanocortin receptor 4 genes. Therapy with human recombinant leptin in patients with genetic deficiency of the hormone is an effective medical treatment of obesity, although only applicable to very few families. The use of leptin-melanocortin agonists, drugs to avoid leptin resistance or combinations of treatments with leptin and other satiating peptides are currently being investigated for multifacotiral human obesity (Rev Méd Chile 2009; 137:1225-34)

Scientific Electronic Library Online (Spanish)

10

Simple quasispecies models for the survival-of-the-flattest effect: The role of space

Sardanyés, Josep; Elena, Santiago F.; Solé, Ricard V.
2008-02-07

Digital.CSIC (Spain)

11

Sequence variability within the tobacco retrotransposon Tnt1 population

Casacuberta, Josep M.; Vernhettes, Samantha; Grandbastien, Marie Angèle
1995-06-01

Digital.CSIC (Spain)

12

Role of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance

Mas, Antonio; Parera, Mariona; Briones, Carlos; Soriano, Vicente; Martínez, Miguel Angel; Domingo, Esteban; Menéndez-Arias, Luis
2000-01-01

Digital.CSIC (Spain)

13

PKC-dependent autoregulation of membrane kainate receptors

Rivera, Rocío; Rozas, José Luis; Lerma Gómez, Juan
2007-10-01

Digital.CSIC (Spain)

14

PHF6 mutations in T-cell acute lymphoblastic leukemia

Van Vlierberghe, Pieter; Palomero, Teresa; Khiabanian, Hossein; Joni Van der Meulen; Castillo, Mireia; Van Roy, Nadine; Moerloose, Barbara de; Philippé, Jan; González-García, Sara; Toribio, María Luisa; Taghon, Tom; Zuurbier, Linda; Cauwelier, Barbara; Harrison, Christine J.; Schwab, Claire; Pisecker, Markus; Strehl, Sabine; Langerak, Anton W.; Gecz, Jozef; Sonneveld, Edwin; Pieters, Rob; Paietta, Elisabeth; Rowe, Jacob M.; Wiernik, Peter H.; Benoit, Yves; Soulier, Jean; Poppe, Bruce; Yao, Xiaopan; Cordon-Cardo, Carlos; Meijerink, Jules; Rabadan, Raul; Speleman, Frank; Ferrando, Adolfo
2010-03-14

Digital.CSIC (Spain)

15

Overexpression of human DNA polymerase µ (Pol µ) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate

Ruiz, José F.; Lucas, Daniel; García-Palomero, Esther; Saez, Ana I.; González, Manuel A.; Piris, Miguel A.; Bernad, Antonio; Blanco, Luis
2004-11-01

Digital.CSIC (Spain)

16

Network design meets in silico evolutionary biology

Rodrigo, Guillermo; Carrera, Javier; Elena, Santiago F.
2010-06-01

Digital.CSIC (Spain)

17

NTF-3, a gene involved in the enteric nervous system development, as a candidate gene for Hirschsprung disease

Ruiz-Ferrer, Macarena; Fernández, Raquel M.; Antiñolo, Guillermo; López-Alonso, Manuel; Borrego, Salud
2008-07-17

Digital.CSIC (Spain)

20

Label-free detection of DNA hybridization based on hydration-induced tension in nucleic acid films

Mertens, Johann; Rogero, Celia; Calleja, Montserrat; Ramos Vega, Daniel; Martín Gago, José Ángel; Briones, Carlos; Tamayo, Javier
2008-04-20

Digital.CSIC (Spain)

22

Identification of a novel bond between a histidine and the essential tyrosine in catalase HPII of Escherichia coli

Bravo, Jerónimo; Fita, Ignasi; Ferrer, Juan C.; Ens, Werner; Hillar, Alex; Switala, Jacek; Loewen, Peter C.
1997-05-01

Digital.CSIC (Spain)

23

High sensitivity to carcinogens in the brain of a mouse model of Alzheimer's disease

Serrano, J.; Fernández, Ana P.; Martínez-Murillo, Ricardo; Martínez, A.
2010-01-25

Digital.CSIC (Spain)

24

High incidence of c-K-ras oncogenes in human colon cancer detected by the RNAse A mismatch cleavage method

Forrester, K.; Almoguera, Concepción; Jordano, Juan; Grizzle, W.E.; Perucho, M.
1987-01-01

Digital.CSIC (Spain)

25
26

Genetic variation, population structure and linkage disequilibrium in peach commercial varieties

Aranzana, Maria José; Abbassi, Kadri El-; Howad, Werner; Arús, Pere
2010-07-20

Digital.CSIC (Spain)

27

Functional characterization of twelve natural PROS1 mutations associated with anticoagulant protein S deficiency

Hurtado, Begoña; Muñoz, Xavier; Mulero, Maria Carme; Navarro, Gemma; Domènech, Pere; García de Frutos, Pablo; Pérez-Riba, Mercè; Sala, Núria
2008-03-05

Digital.CSIC (Spain)

28

Evaluación de la reacción al virus del mosaico en plantas de caña de azúcar provenientes de callos irradiados ¹

Fuchs, Morela; González, Ventura; Castroni, Sonia; Díaz, Ezequiel; Castro, Luis
2002-09-01

Resumen en español Se indujo variabilidad genética en plantas regeneradas de caña de azúcar, Saccharum sp., mediante la combinación de la técnica de cultivo in vitro de callos y la inducción de mutaciones con rayos gamma, con la finalidad de obtener genotipos resistentes al virus del mosaico de la caña de azúcar (SCMV) a partir de variedades (B6749, B7987 y PR62258) susceptibles al virus, sus callos fueron irradiados con rayos gamma (0,2; 4,8 y 12 Kr), utilizando para ello una fuent (mas) e de Co60. Un total de 3.502 plantas fueron regeneradas, llevadas a umbráculo e inoculadas cinco veces con la raza B del SCMV, preparado de hojas de la variedad C571, altamente susceptible. Plantas de sorgo de la variedad Río se emplearon como control. De las plantas regeneradas, un 82% permaneció libre de síntomas; las mismas fueron trasplantadas y llevadas al campo para observar la incidencia de infestación natural. De estas 1 607 plantas, 911 permanecieron sin síntomas, así de un 82% de las plantas que sobrevivieron a la inoculación artificial un 46% permaneció sin síntomas de la enfermedad después de la exposición en el campo. Susceptibilidad a la roya fue también observada en condiciones de campo en aquellas plantas provenientes de variedades resistentes a la enfermedad Resumen en inglés Summary By the combination of in vitro culture technique and induction of mutations with rays, genetic variability was induced in regenerated sugarcane plants with the purpose of obtaining resistant genotypes to mosaic virus of sugarcane, Saccharum sp., beginning from varieties susceptible to the virus. Three varieties susceptible to mosaic virus (B6749, B7987 and PR62258) were selected and their calluses irradiated with gamma rays (0, 2, 4, 8 and 12 Kr) using a source of (mas) Co60. A total of 3.502 plants were regenerated. Plants were transferred to the greenhouse and inoculated five times with the B race of SCMV, prepared from leaves of a highly susceptible variety, C571. Sorghum variety Rio indicator plants were used as control. Eighty two percent of regenerated plants remained free of symptoms of mosaic and were transplanted to the field for further observation of natural infectation incidences. Of these 1.607 plants, 911 remained without symptoms. In this way 46% out of 82% of plants that survived artificial inoculation remained symptom less after being exposed to field conditions. Under field conditions, rust susceptibility was also observed in plants obtained from disease resistant varieties

Scientific Electronic Library Online (Spanish)

30

El splicing alternativo del exón 5 de la citocromo p450 aromatasa podría ser un mecanismo de regulación de la producción de estrógenos en humanos/ Exon 5 alternative splicing of the cytochrome P450 aromatase could be a regulatory mechanism for estrogen production in humans

Pepe, Carolina M.; Saraco, Nora I.; Baquedano, María Sonia; Guercio, Gabriela; Vaiani, Elisa; Berensztein, Esperanza; Rivarola, Marco A.; Belgorosky, Alicia
2007-08-01

Resumen en español La enzima P450 aromatasa (P450Aro) participa en la síntesis de estrógenos a partir de andrógenos. La mutación c655G>A, descripta en forma heterocigota en una niña y en forma homocigota en un hombre adulto, ambos con déficit de aromatasa, genera la disrupción del sitio dador de splicing exón5-intrón5. Se ha postulado que la retención del intrón5 y la generación de una proteína truncada inactiva serían las consecuencias de esta mutación. Sorpresivamente, la p (mas) aciente presentó desarrollo espontáneo de mamas y niveles puberales de estradiol, sugiriendo una actividad aromatasa (AA) residual. En principio postulamos que la mutación c655G>A generaría la pérdida del exón5 con conservación del marco de lectura, generándose una proteína con menor actividad que podría explicar el déficit parcial. La expresión del ARNm sin exón5 (ARNm- E5) en linfocitos de la paciente sugiere una asociación entre la pérdida del exón y la presencia de la mutación; posteriormente confirmada realizando ensayos de splicing en células Y1. Sin embargo, la expresión del cDNAE5 en células Y1 presentó una AA nula que no explicaría un déficit parcial. La expresión del ARNm-E5 fue detectada en placenta, testículo y adrenal humanos como una variante de splicing normal. Estos resultados indicarían la ocurrencia de splicing alternativo (SA) en la zona codificante de P450Aro como un posible mecanismo regulador de la producción de estrógenos en tejidos esteroidogénicos humanos. La mutación c655G>A podría alterar los mecanismos fisiológicos reguladores del SA del exón5 favoreciendo su exclusión. De esta forma, bajos niveles de ARNm+E5 podrían expresarse aun en presencia de la mutación explicando el fenotipo de déficit parcial observado en la paciente. Resumen en inglés P450 aromatase (P450Aro), involved in androgen to estrogen conversion, is encoded by the CYP19 gene. P450Aro c655G>A mutation described in heterozygous form in a girl and in homozygous form in an adult male with P450Aro deficiency results in an aberrant splicing due to disruption of a donor splice site. A truncated inactive protein would be expected if intron5 is retained. Surprisingly, the girl described with this mutation showed spontaneous breast development and pubert (mas) al estradiol (E2) levels suggesting residual P450Aro activity (AA). Formerly, we postulate the in frame E5 skipping as a consequence of this mutation generating a protein with some degree of activity. When P450Aro mRNA expression was analysed from patient's lymphocytes, an aberrant spliced mRNA lacking E5 (-E5mRNA) was detected, suggesting an association between E5 skipping and the presence of the mutation. Splicing assays in Y1 cells confirmed this association. -Ex5 cDNA expression in Y1 cells resulted in an inactive protein that could not explain patient's phenotype. Exon 5 might be predicted as a poorly defined exon suggesting a susceptibility to splicing mutations and physiological alternative splicing (AS) events. Therefore, -Ex5mRNA was assessed as a natural occurring alternative transcript in normal human steroidogenic tissues. As P450Aro -E5mRNA expression was detected in human term placenta, prepubertal testis and prepubertal adrenal, we might speculate that AS of P450Aro coding region would occur in humans and would be involved in the complex AA regulation. Furthermore, tissue specific regulation of AS might suggest low expression of +E5mRNA from the c655G>A allele explaining residual AA evidenced in the affected girl.

Scientific Electronic Library Online (Spanish)

31

EcoTILLING for the identification of allelic variants of melon eIF4E, a factor that controls virus susceptibility

Nieto, Cristina; Piron, Florence; Dalmais, Marion; Gómez-Guillamón, M. L.; Truniger, Verónica; Gómez, Pedro; Garcia-Mas, Jordi
2007-06-21

Digital.CSIC (Spain)

32

EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa

Abd El-Aziz, Mai M.; Barragán, Isabel; O'Driscoll, Ciara A.; Goodstadt, Leo; Prigmore, Elena; Borrego, Salud; Mena, Marcela; Pieras, Juan I.; El-Ashry, Mohamed F.; Abu Safieh, Leen; Shah, Amna; Cheetham, Michael E.; Carter, Nigel P.; Chakarova, Christina; Ponting, Chris P.; Bhattacharya, Shomi S.; Antiñolo, Guillermo
2008-10-05

Digital.CSIC (Spain)

33

Distributions of epistasis in microbes fit predictions from a fitness landscape model

Martin, Guillaume; Elena, Santiago F.; Lenormand, Thomas
2007-03-18

Digital.CSIC (Spain)

34
36

Comparison of translation loads for standard and alternative genetic codes

Sammet, Stefanie Gabriele; Bastolla, Ugo; Porto, Markus
2010-06-14

Digital.CSIC (Spain)

37

Collective properties of evolving molecular quasispecies

Stich, Michael; Briones, Carlos; Manrubia, Susanna C.
2007-07-09

Digital.CSIC (Spain)

38

Characterization of a Natural Mutator Variant of Human DNA Polymerase l which Promotes Chromosomal Instability by Compromising NHEJ

Terrados, Gloria; Gapp, Jean-Pascal; Canitrot, Yvan; García, Miguel Ángel; Bebenek, Katarzyna; Kirchhoff, Tomas; Villanueva, Alberto; Boudsocq, François; Bergoglio, Valerie; Cazaux, Christophe; Kunkel, Thomas A.; Hoffmann, Jean-Sebastien; Blanco, Luis
2009-06-10

Digital.CSIC (Spain)

40

Atom-by-atom analysis of global downhill protein folding

Sadqi, Mourad; Fushman, David; Muñoz van den Eynde, Víctor
2006-06-14

Digital.CSIC (Spain)

41

An internal ribosome entry site element directs the synthesis of the 80 kDa isoforms of protein 4.1R

Lospitao, Eva Pilar; Pérez-Ferreiro, Carmen; Gosálbez, Altea; Alonso, Miguel A.; Correas, Isabel
2008-12-04

Digital.CSIC (Spain)

42

A protein key to plant virus transmission at the tip of the insect vector stylet

Uzest, M.; Gargani, D.; Drucker, M.; Hebrard, E.; Garzo, E.; Candresse, T.; Fereres, Alberto; Blanc, S.
2007-11-13

Digital.CSIC (Spain)

44

A burst of segmental duplications in the genome of the African great ape ancestor

Marqués-Bonet, Tomàs; Kidd, Jeffrey M.; Ventura, Mario; Graves, Tina A.; Cheng, Ze; Hillier, LaDeana W.; Jiang, Zhaoshi; Baker, Carl; Malfavon-Borja, Ray; Fulton, Lucinda A.; Alkan, Can; Aksay, Gozde; Girirajan, Santhosh; Siswara, Priscillia; Chen, Lin; Cardone, Maria Francesca; Navarro, Arcadi; Mardis, Elaine R.; Wilson, Richard K.; Eichler, Evan E.
2009-02-12

Digital.CSIC (Spain)