Sample records for HIGADO (liver)
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1

Hígado graso no alcohólico. Nuevos conceptos/ An update on non-alcoholic fatty liver disease

Méndez Sánchez, Nahum; Chávez-Tapia, Norberto C.; Uribe, Misael
2004-02-01

Resumen en español El hígado graso no alcohólico es una enfermedad emergente de gran importancia en el momento actual. Esta entidad se asocia frecuentemente con obesidad y resistencia a la insulina. Su prevalencia y gravedad están en relación con variables como el índice de masa corporal, cintura, hiperinsulinemia, hipertrigliceridemia y resistencia a la insulina. La identificación de estos pacientes es de capital importancia con el objetivo de prevenir las complicaciones potenciales (mas) como la esteatohepatitis no alcohólica o la cirrosis. Dentro de la patogenia del hígado graso no alcohólico se han descrito alteraciones funcionales y morfológicas a nivel mitocondrial, otros factores implicados son una mayor susceptibilidad a estímulos nocivos, incremento en la actividad inflamatoria y modificaciones en la maquinaria celular a nivel postreceptor. Por lo tanto, las modalidades terapéuticas son diversas, siendo la medida más útil el adecuado control del peso, así como el manejo de las enfermedades concomitantes. El uso de antioxidantes y otros fármacos citoprotectores como el ácido ursodesoxicólico han mostrado cierto beneficio, aunque se requieren análisis a largo plazo para corroborar estas observaciones. En esta revisión analizamos los conceptos más recientes sobre epidemiología, fisiopatología y tratamiento de esta enfermedad. Resumen en inglés Non alcoholic fatty liver disease is a disease of emerging identity and importance. It is frequently associated with obesity, especially visceral fat, and is intimately related to fatty liver and markers of insulin resistance. Both the prevalence and the severity of liver steatosis are related to body mass index, waist circumference, hyperinsulinaemia, hypertriglyceridaemia and impaired glucose tolerance or type 2 diabetes. The identification fatty liver disease in obese (mas) patients, is very important in order to prevent complications such as steathohepatitis and cirrhosis. The pathogenesis of non alcoholic fatty liver disease is very complex, there are mitochondrial morphologic and functional alterations, as well as, high sensitivity to injurious stimulus, an increased inflammatory activity, and modifications in cellular metabolism at post-receptor level. Weight reduction is one of the first steps in the treatment of patients with non alcoholic fatty liver disease, as well as the management of associated conditions such as obesity, diabetes mellitus and hyperlipidaemia. Antioxidants, and others drugs such as ursodeoxycholic acid may be beneficial in the treatment of non alcoholic fatty liver disease. These medications, however, need first to be tested in well-controlled trials with clinically relevant end-points and extended follow-up. In this review, we analyze the new concepts in epidemiology, pathophysiology and treatment of this disease.

Scientific Electronic Library Online (Spanish)

4

Angiomiolipoma de hígado: Un tumor hepático benigno poco frecuente/ Angiomyolipoma of the liver: An uncommon benign liver tumor

Martín Carvajal, F.; Fernández García, F. J.; Gómez Modet, S.; Sánchez Viguera, T.; Gutstein Feldman, D.
2007-01-01

Scientific Electronic Library Online (Spanish)

5

Hepatotoxicidad en el paciente crítico: El hígado bajo agresión aguda grave/ Hepatotoxicity in the critically ill patient: The liver under an acute severe insult

García de Lorenzo y Mateos, A.; Rodríguez Montes, J. A.
2008-05-01

Resumen en español El hígado desempeña un papel fundamental en el metabolismo de la mayoría de los nutrientes pues es un órgano principalmente metabólico y lleva a cabo una serie de procesos fisiológicos y bioquímicos relacionables con el metabolismo proteico y energético. Consideramos al tracto gastrointestinal como una pieza clave en el desarrollo del Fallo o Disfunción Multiorgánica (DMO) como consecuencia de una pérdida de su función de barrera (alteración de la permeabilid (mas) ad) secundaria a hipoxia frente a toxinas, bioproductos y ocasionalmente bacterias intraluminales, siendo uno de los principales mecanismos fisiopatogénicos el insuficiente flujo de sangre a los órganos esplácnicos. La disfunción hepática y/o alteración en los test de función hepática es un evento común entre los pacientes críticos. Puede estar originada por una cirrosis previa o por causas más inmediatas de insuficiencia- fallo hepático como la sepsis, drogas, transplante hepático o alguna de las múltiples etiologías de la hepatitis. Resumen en inglés The liver plays an essential role in the metabolism of most of the nutrients since it is a mainly metabolic organ carrying out a series of physiological and metabolic processes related with protein and energy metabolism. The intestinal tract is considered a key element in the development of Multiorgan Dysfunction (MOD) or failure by loosing its barrier function (impaired permeability) against toxins, bio-products and occsaionally intraluminal bacteria secondary to hypoxia (mas) , one of the main pathopysiogenic mechanisms being the insufficient blood flow to splacnic organs. Liver dysfunction and/or impairment of liver function test are a common event in critically ill patients. They may be due to previous liver cirrhosis or to more immedite causes of liver failure such as sepsis, drugs, liver transplant or any of the multiple etiologies for hepatitis.

Scientific Electronic Library Online (Spanish)

7
8

Relationship of mild fatty liver, β-carotene, vitamins a and e status of periparturient Holstein cows/ Relación del hígado graso leve y el estatus de β-caroteno, vitaminas A y E en vacas Holstein durante el periparto

Rosendo, Oswaldo; McDowell, Lee R; Staples, Charles; Shearer, Jean K; Wilkinson, Nancy S; Seymour, William M
2010-07-01

Resumen en español Este estudio fue realizado con los objetivos de determinar la asociación entre hígado graso leve (HGL) y estatus de β-caroteno (BC), retinol (ROL) y a-tocoferol (AT). Para definir HGL en vacas Holstein multíparas se empleó como valor crítico el 2% de triacilgliceroles (TAG, base fresca) en el hígado al segundo día después del parto. El consumo de materia seca (CMS), como porcentaje del peso vivo, disminuyó (3,47 vs. 3,99; P = 0,02) mientras que la concentrac (mas) ión de ácidos grasos no-esterificados (AGNE) incrementó (345,0 vs. 266,0 µeq/dL; P = 0,10), desde el parto hasta la 5ta semana de lactancia en las vacas con HGL en comparación con las vacas control. El hígado graso tuvo la tendencia a disminuir el ROL plasmático (0,20 vs. 0,23 µg/mL, P = 0,10), pero no afectó las concentraciones de BC y AT en plasma, ni las de BC y ROL hepático (P > 0,12). Sin embargo, en el parto, la caída del BC hepático fue muy pequeña (8,0 vs. 68,0%) en las vacas con HGL. Las concentraciones de AT hepático fueron mayores (5,5 vs. 4,0 µg/g, P = 0,06) en las vacas con más de 2% de TAG hepático. La concentración plasmática de AGNE tuvo una correlación positiva con las concentraciones plasmáticas de BC (r = 0,18; P Resumen en inglés The objectives of this study were to determine the association between mild fatty liver and β-carotene (BC), retinol (ROL), and a-tocopherol (AT) status. Multiparous Holstein cows were defined as having mild fatty liver using a threshold of 2% liver triacylglycerol (TAG, wet basis) at day (d) 2 after calving. Cows with mild fatty liver decreased dry matter intake (DMI) as a % of body weight (BW) from calving to 5th week (wk) of lactation (3.47 vs. 3.99, P = 0.02) and (mas) increased plasma nonesterified fatty acids (NEFA) concentration (345.0 vs. 266.0 µeq/dL, P = 0.10) as compared to normal cows. Fatty liver tended to lower plasma ROL (0.20 vs. 0.23 µg/mL, P = 0.10), but had no effect on plasma BC, plasma AT, liver BC, and liver ROL (P > 0.12) concentrations. However, depression in liver BC at calving was very small (8.0 vs. 68.0%) for fatty liver than for normal cows. Liver AT concentrations were greater (5.5 vs. 4.0 µg/g, P = 0.06) for cows with more than 2% liver TAG concentration. Concentration of plasma NEFA was positively correlated with plasma BC concentrations (r = 0.18, P

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9

Determinación de tioles totales y tioles solubles en ácido en el pez colossoma macropomum (cuvier, 1818) expuesto a cadmio/ Total and Soluble Thiols in Acid Determination on the Freshwater Fish Colossoma macropomum (Cuvier, 1818) Exposed to Cadmium

Salazar-Lugo, Raquel; Pérez, Roylda; León, Alida; Lemus, Mairin; Rojas de Astudillo, Luisa
2009-08-01

Resumen en español En el presente estudio se evaluó la distribución de tioles totales y de tioles solubles en ácido en diferentes tejidos del pez dulceacuícola Colossoma macropomum en condiciones de cultivo, y aclimatados en el laboratorio durante 15 y 30 días, y el efecto del cadmio sobre estos parámetros en organismos expuestos durante 21 días y depurados 15 días después de la exposición al metal. La distribución de tioles totales (TT) y de tioles solubles en ácido (TSA) vari� (mas) � con las condiciones ambientales en las cuales se encontraban los organismos, observándose que en peces en cultivo, los mayores valores de TT se presentan en el plasma>músculo>branquias, en peces aclimatados a condiciones de laboratorio (15 días), se observó la siguiente distribución: branquias>músculo>hígado>plasma>riñón y en peces aclimatados 30 días fue branquias>riñón>hígado>músculo>plasma. Para los TSA, la distribución fue la siguiente: organismos provenientes de condiciones de cultivo: músculo>plasma>hígado>branquias. En los peces con 15 días de aclimatación: hígado>branquias>músculo; el riñón y el plasma presentaron valores cercano a cero. En peces con 30 días de aclimatación fue branquias>músculo>hígado>riñón>plasma. La exposición crónica a cadmio produjo un aumento significativo de la concentración de TT y de TSA en el plasma. Los organismos depurados 15 días disminuyeron la concentración de TSA en plasma no así la de TT. La determinación de tioles, podría considerarse un importante parámetro auxiliar, en el diagnóstico y monitoreo de peces expuestos a ambientes contaminados por cadmio. Resumen en inglés In this study was evaluated the distribution of total thiols (TT) and acid soluble thiols (AST) in tissues of the freshwater fish Colossoma macropomum providing of cultivation and acclimated in laboratory by 15 and 30 days, as well, was evaluated the effect of cadmium on these parameters in Cd-exposure fishes during 21 days and in Cd-depuration fishes (15 days). TT and AST showed variations with environmental conditions; In Farmer fishes were, TT: plasm>muscle>gills; accl (mas) imated fishes (15 days): gills>muscle>liver>plasm>kidney and acclimated fishes (30 days): gills>kidney>liver>muscle>plasm. The distribution of AST was: farmer fishes: muscle>plasm>liver>gills. Acclimated fishes (15 days): liver>gills>muscle; the kidney and the plasm presented near values to zero, and acclimated fishes (30 days) was gills>muscle>liver>kidney>plasm. Cadmium exposition produced a significant increase in the TT and TSA concentration of plasm. Cd-depured fishes showed a decrease in plasm TSA concentration but not in plasm TT concentration. Thiol assays could be considered an important parameter in the diagnosis and monitor of fishes environmental Cd exposed.

Scientific Electronic Library Online (Spanish)

10

Trasplante hepático de donador vivo adulto-adulto/ Liver transplantation of living donor adult-to-adult

Vilatobá, Mario; Eckhoff, Devin E.; Contreras, Juan L.
2005-04-01

Resumen en español El trasplante hepático ha sido una terapéutica aceptada por más de 20 años. A pesar de los esfuerzos sociales y legislativos, el número de órganos cadavéricos disponibles no se ha incrementado en la misma proporción que los pacientes con enfermedad hepática terminal. El tiempo y la mortalidad en la lista de espera se han incrementado dramáticamente. Para tratar de compensar esta disparidad, se han desarrollado nuevas técnicas para incrementar el número de órg (mas) anos, como son: la división de un hígado en dos injertos o utilizar un lóbulo o segmentos del hígado de un donador vivo. Esta revisión se enfocará en el trasplante hepático del lóbulo derecho de donador vivo adulto-adulto. Resumen en inglés End-stage liver disease Is being treated by liver transplantation since more than 20 years. Despite social and legislative efforts, the number of cadaveric organs suitable for liver transplantation has not grown to mach the surplus of patients with end-stage liver disease. Whit the growing discrepancy between donors and recipients, the median waiting time for liver transplantation has increases dramatically. As a result, the number of patients who die while waiting is inc (mas) reasing. To attempt to meet the growing needs of recipients, surgeons are developing innovative techniques to increase the number of donated livers. These include: split liver transplantation and transplantation of a part of the liver from living donors. This review will focus on adult-to-adult transplantation of the right lobe from a living donor.

Scientific Electronic Library Online (Spanish)

11

Estudio histopatológico de las lesiones hepáticas inducidas por paraquat/ Histopathological study of paraquat induced hepatotoxicity

Salguero Villadiego, M.; Martínez Sánchez, MC.; Soria Sánchez, ML.; García Rodríguez, S.; Repetto Kuhn, G.
2005-04-01

Resumen en español Se realiza el estudio histopatológico de las lesiones que el paraquat produce en el hígado. El estudio microscópico de los 15 casos revisados indica el posible papel que la lesión del endotelio juega en el desarrollo de la lesión hepatotóxica producida este plaguicida. Resumen en inglés The aim of this study is to describe the histopathological characteristics of the liver damage in paraquat poisoning. The microscopic characteristics of the liver damage in the 15 cases reviewed emphasize the possible role of the endothelial lesions in the development and pathological expression of liver damage.

Scientific Electronic Library Online (Spanish)

12

Fundamento molecular de la esteatosis hepática asociada a la obesidad/ Molecular basis of obesity-related hepatic steatosis

Buqué, X.; Aspichueta, P.; Ochoa, B.
2008-09-01

Resumen en español La enfermedad del hígado graso no alcohólico es una enfermedad inflamatoria hepática de carácter crónico de gran relevancia en la actualidad por su fuerte asociación con enfermedades de incidencia creciente como la obesidad y la diabetes mellitus tipo 2. En este trabajo se recoge buena parte del conocimiento existente sobre los mecanismos moleculares implicados en el establecimiento de la esteatosis hepática, el primer estadio de la enfermedad, y en su progreso a e (mas) steatohepatitis. Se ha prestado una atención especial al hígado graso asociado a la obesidad, clínica y experimental. En este caso, se valora la rata fa/fa, un modelo animal de obesidad con rasgos fenotípicos similares a los de la obesidad humana, incluyendo la resistencia a la insulina y la dislipemia. La esteatosis hepática se revela como una situación compleja, eminentemente metabólica, en la que se simultanean procesos metabólicos aparentemente contradictorios, así como estrés oxidativo, estrés de retículo endoplasmático, disfunción mitocondrial y descenso en la expresión de genes de supervivencia. En buena medida, en su base se sitúan señales extrahepáticas, como las producidas en una situación de resistencia periférica a la insulina asociada a un aumento de la masa adiposa y de ácidos grasos libres sistémicos, e internas, causantes de un desajuste de las funciones glucostática y lipidostática del hígado y de una mayor vulnerabilidad a otras agresiones. Resumen en inglés Non-alcoholic fatty liver disease is a chronic inflammation liver condition that is currently highly relevant because of its strong association with increasingly incident diseases such as obesity and type-2 diabetes mellitus. The primary purpose of this paper is to discuss the best part of current knowledge on the molecular mechanisms involved in hepatic steatosis development, the condition's initial stage, and on progression to steatohepatitis. Special attention has been (mas) paid to clinical and experimental obesity-related fatty liver. In the latter, the fa/fa rat is assessed, which constitutes an animal model for obesity with phenotype features similar to human obesity, including insulin resistance and dyslipemia. Hepatic steatosis is a complex, mainly metabolic condition where apparently non-compatible metabolic processes concur, in addition to oxidative stress, endoplasmic reticulum stress, mitochondrial dysfunction, and decreased expression of survival genes. Extrahepatic signals underlie the disorder, such as those arising from peripheral insulin resistance associated with an increase in adipose mass and systemic free fatty acids, together with intrahepatic signals leading to derangement of liver glycostatic and lipidostatic functions, as well as to greater vulnerability to other aggressions.

Scientific Electronic Library Online (Spanish)

13

Técnicas quirúrgicas en trasplante hepático/ Surgical techniques in liver transplantation

Chan, Carlos; Plata-Muñoz, Juan José; Franssen, Bernardo
2005-04-01

Resumen en español Probablemente, el trasplante hepático (TH) constituye la mayor agresión quirúrgica a la que se pueda someter un paciente. En la era experimental del trasplante de hígado, éste era considerado como una terapéutica de último recurso. Con el paso del tiempo ha terminado por imponerse como el tratamiento definitivo de algunas hepatopatías agudas y crónicas terminales. Técnicamente, el trasplante de hígado es el más complejo de todos los trasplantes. La técnica qu (mas) irúrgica está bien establecida desde hace muchos años y no ha cambiado mucho. Más que a los avances recientes de la técnica, el TH debe su evolución quirúrgica al dominio protocolizado de la técnica anestésica y de los cuidados perioperatorios. La técnica quirúrgica inicial fue descrita por Thomas Starzl en 1969. Sus aportaciones iniciales han sido fortalecidas con el desarrollo de un sistema de derivación de la sangre venosa, el perfeccionamiento en la reconstrucción vascular y biliar y el desarrollo de avanzadas técnicas de reducción o de bipartición del injerto hepático. En el presente artículo se describen aspectos técnicos actuales relacionados con el trasplante hepático ortotópico (THO). Resumen en inglés Liver transplantation (LT) is probably the biggest surgical aggression that a patient can endure. It was considered only as a last option in the era of experimental LT, yet it evolved into the definitive treatment for some types of acute and chronic end stage liver disease. In terms of technique LT is the most complex of all types of transplantations. The surgical procedure in itself is well established and has changed little through time. Liver transplantation owes its i (mas) mprovement to better and more systematic anesthetic procedures and to perioperative care more than being due to improvement of the surgical technique. The first surgical procedure was described by Thomas Starzl in 1969. His initial work has been strengthened with the development of venous bypass, the refinement in vascular and biliary reconstruction technique and the development of the split liver. Up to date technical aspects of orthotopic liver transplantation are described in the present article.

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14

Epidemiología y factores de riesgo de carcinoma hepatocelular/ Epidemiology and risk factors of hepatocellular carcinoma

BOTERO TORO, ALEJANDRA; LONDOÑO SANIN, MARCELA; NAVAS NAVAS, MARIA-CRISTINA
2007-03-01

Resumen en español El cáncer primario de hígado es en el mundo la quinta neoplasia más común en hombres y la octava en mujeres, con gran impacto debido a su alta mortalidad, ya que representa la tercera causa de mortalidad relacionada con cáncer en población masculina. Se ha descrito una fuerte asociación con factores de riesgo como las hepatitis virales crónicas, las hepatopatías de origen genético, el consumo de alcohol, el tabaquismo y enfermedades metabólicas, entre otras. En (mas) este artículo se analizan publicaciones originales y de revisión en las que se evalúan dichos factores y su asociación con el carcinoma hepatocelular (CHC). Además, se recopila información actualizada sobre datos epidemiológicos por regiones del mundo. Resumen en inglés Primary liver cancer is the 5th neoplasia more common among men and 8th among women worldwide. It has a great impact because of its high mortality; Liver cancer ranks third amongst the causes of cancer-related deaths in men. It has been associated with some risk factors as chronic viral hepatitis, genetic liver disease, intake of alcohol, use of tobacco, metabolic disease and others. This document corresponds to a review of original papers of evaluation of those factors a (mas) nd its association with liver cancer and also reviewed articles. Additionally, updated epidemiological information of liver cancer worldwide is included.

Scientific Electronic Library Online (Spanish)

15

Amiloidosis hepática como causa de colestasis severa intrahepática/ Primary amyloidosis as a cause of severe intrahepatic cholestasis

Gavilán, J. C.; Bermúdez, F. J.; Márquez, A.; Sánchez-Carrillo, J. J.; González-Santos, P.
2003-01-01

Resumen en español El hígado suele verse afectado en la amiloidosis sistémica; sin embargo, la hiperbilirrubinemia y los signos de fallo hepático son manifestaciones muy poco comunes. Una elevación ligera de las cifras de fosfatasa alcalina y, menos frecuentemente, la existencia de hepatomegalia son los hallazgos más habituales. Generalmente, los pacientes no refieren manifestaciones clínicas relacionadas con la afectación hepática; las manifestaciones clínicas y el pronóstico a l (mas) argo plazo dependen de la existencia de afectación renal y cardíaca. Comunicamos un caso de amiloidosis primaria con una presentación clínica poco usual, en una mujer de 65 años de edad, que fue ingresada por un cuadro de ictericia, ascitis y fallo hepático agudo atribuído a hepatitis inducida por fármacos. Resumen en inglés The liver is frequently involved by amyloidosis, but hyperbilirubinemia and liver failure are uncommon features. A mild elevation of the serum alkaline phosphatase value and, less frequently, hepatomegaly are the most common findings. Usually the patients have no symptoms related with the liver involvement; the clinical manifestation and the long term prognosis depends on the renal and cardiac disease. We report an unusual clinical presentation of primary amyloidosis in a (mas) previously asymptomatic 65 years old woman who was admitted to the hospital because of ictericia and ascitis mimicking a drug induced acute hepatic failure.

Scientific Electronic Library Online (Spanish)

16

Trastornos de coagulación en el cirrótico/ Coagulation disorders in cirrhosis

Téllez-Ávila, Felix I; Chávez-Tapia, Norberto C; Torre-Delgadillo, Aldo
2007-04-01

Resumen en español El hígado participa de manera importante en el proceso de la coagulación. En él se sintetizan la mayor parte de los factores pro- y anticoagulantes. De manera histórica se ha considerado que las alteraciones en la función de este órgano provoca trastornos predisponentes para eventos de sangrado. La evidencia actual pone en tela de juicio esta aseveración. En los casos de hepatopatía se hacen evidentes alteraciones en el número y funcionamiento de las plaquetas, d (mas) isminución de la síntesis de factores de la coagulación, disfibrinogenemia, alteraciones en la fibrinólisis, deficiencia de vitamina K y cambios similares a los ocurridos en la coagulación intravascular diseminada (CID). El presente trabajo está dirigido a revisar los conocimientos actuales respecto a las alteraciones de la coagulación presentes en los pacientes con hepatopatías. Resumen en inglés The liver plays a central role in the clotting process. In this organ are sintetizated the major part of the coagulation factors. Historically, was considered that alteration in liver function causes important bleeding disorders. However, actual evidence is not in agreement with this asseveration. Decreased synthesis of clotting and inhibitor factors, decrease clearance of activated factors, quantitative and qualitative platelet defects, hyperfibrinolysis and intravascula (mas) r coagulation are some of the defects observed in liver diseases. Thrombotic events, even if rare in cirrhotic patients, occur manly in the portal and mesenteric veins. The aim of the present work is to review the present evidence in coagulation disorders and liver disease.

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17

Trasplante hepático en niños/ Pediatric liver transplantation

Varela-Fascinetto, Gustavo; Dávila-Pérez, Roberto; Hernández-Plata, Alejandro; Castañeda-Martínez, Pedro; Fuentes-García, Víctor; Nieto-Zermeño, Jaime
2005-04-01

Resumen en español El trasplante hepático pediátrico ha evolucionado durante las últimas dos décadas, hasta convertirse en una terapia efectiva y ampliamente aceptada para tratar lactantes y niños. Estos pacientes, considerados de alto riesgo, actualmente logran tasas de sobrevida actuarial al año cercanas a 85-90%, con una excelente calidad de vida después del trasplante. Este artículo revisa las particularidades del receptor pediátrico, las innovaciones quirúrgicas que se desarr (mas) ollaron para poderles ofrecer un trasplante (trasplante reducido, de donador vivo, dividido o "split" y auxiliar parcial), los puntos más importantes del manejo anestésico, inmunosupresión y cuidados postrasplante en niños, y un panorama de los resultados actuales a nivel mundial. Se presenta además la experiencia del Hospital Infantil de México Federico Gómez, que cuenta con la serie de trasplante hepático en niños más grande y con mejores resultados del país, el primer trasplante de hígado de donador vivo con éxito y el primer trasplante hepático-renal simultáneo en un niño en México. Resumen en inglés Pediatric liver transplantation has evolved over the last two decades into an effective and widely accepted therapy for infants and children. Currently, these high-risk patients achieve 85 to 90% one-year patient survival and an excellent quality of life. This paper reviews the special features of the pediatric recipient, the surgical innovations developed to be able to offer them a transplant (reduced size, live donor, split, and auxiliary partial transplantation), the m (mas) ost significant issues in anesthetic, immunosuppressive and postoperative care in children, as well as a global picture of the results. Additionally, the experience of the Hospital Infantil de México Federico Gómez is presented, as the largest and most successful series of pediatric liver transplantation in the country, where the first successful live donor liver transplantation and the first simultaneous liver-kidney transplantation in a child were performed.

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18

Esteatohepatitis no alcohólica: el enigma de una mala evolucion/ Nonalcoholic steatohepatitis: the enigma of bad progress

López-Diéguez Puerta, M.; Casal Esteban, V.; Barbado Hernández, F. J.; Gil Guerrero, L.; Rodríguez Molinero, M. A.; Larrauri, J.; Vázquez Rodríguez, J. J.
2005-02-01

Resumen en español Hasta ahora poco se sabe acerca de la patogenia, los desencadenantes y en particular de la evolución y terapia de la esteatohepatitis no alcohólica (EHNA). Incluída en el amplio espectro de enfermedades del hígado graso no alcohólicas. Se ha considerado una enfermedad mayoritariamente benigna y asociada a alteraciones metabólicas muy prevalentes en la población general. Sin embargo no es raro que progrese a cirrosis, insuficiencia hepática o hepatocarcinoma que pr (mas) ecise transplante hepático. Presentamos el caso de una paciente que diagnosticamos de EHNA, al inicio con respuesta parcial y tardía al tratamiento para el sobrepeso, la HTA y la hiperlipidemia, pero con una evolución rápida a cirrosis hepática sin identificarse ningún factor desencadenante. Actualmente es candidata a transplante hepático. Son necesarios estudios multicéntricos y controlados, con la misma definición de EHNA y objetivos comunes que aportarán información sobre datos diagnósticos y nuevas terapias para el manejo precoz de la enfermedad. Resumen en inglés Still, very little is known about the precise pathogenetic mechanisms, the triggering events and in particular, the evolution and treatment of non-alcoholic steatohepatitis (NASH). It is part of the broad spectrum of nonalcoholic fatty liver diseases ( NAFLDs). Mainly, it has been reported as a benign disease, asociated with metabolic disorders commonly occurrence en the general population. Nevertheless, the syndrome can lead to cirrhosis, liver failure or hepatocellular (mas) carcinoma, requiring liver transplantation. We present one pacient with diagnosis of NASH, who was treated initially for overweight, HTA and hyperlipaemia with incompleted response and who showed a quickly progress to cirrosis but no cause of liver descompensated disease could be identified. Currently she is at end-stage waitting a liver transplantation. Controlled and multicentric studies with the same definition of NASH and the study end-points are needed, and will provide information about diagnosis features and novel therapies to early management of the disease.

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19

Complicaciones hepáticas asociadas al uso de nutrición parenteral/ Parenteral nutrition-associated liver disease

Moreno Villares, J. M.
2008-05-01

Resumen en español La afectación hepática relacionada con la nutrición parenteral (PNALD) es un problema importante especialmente en los pacientes que requieren nutrición parenteral durante un tiempo prolongado y en los recién nacidos prematuros. La prevalencia es muy variable según las series y existen diferencias en la presentación entre los niños y los pacientes adultos. A pesar de haberse propuesto diferentes teorías en relación a la patogénesis del cuadro, su etiología no e (mas) stá bien definida. Es probable que intervengan varios factores al mismo tiempo. Podemos dividir los factores de riesgo de PNALD en tres grandes grupos: 1) derivados de la alteración de la función intestinal secundaria a la ausencia de estímulos enterales; 2) componentes de la NP que actúen como tóxicos para el hígado o la ausencia de determinados nutrientes que ocasionen afectación hepática, y 3) la contribución de la enfermedad de base. Cuando la NP es de corta duración y la afectación hepática se limita a una elevación de los enzimas de función hepática, generalmente no precisa ningún tratamiento. Cuando aparece una bilirrubina directa > 2 mg/dl durante un periodo largo y persiste la necesidad de NP es necesario primero descartar otras posibles causas de afectación hepática y luego minimizar los factores de riesgo. Se repasan en este artículo las distintas estrategias de manejo de la PNALD, incluyendo la estimulación enteral, el ajuste en el aporte de nutrientes, la adición de nutrientes específicos -taurina, colina- o el uso de fármacos coleréticos como el ácido ursodeoxicólico. Si la enfermedad hepática progresa puede llevar a una cirrosis y obligar a la realización de un trasplante hepato-intestinal. Resumen en inglés Parenteral nutrition associated liver disease (PNALD) is an important problem in patients who require longterm parenteral nutrition as well as in preterm infants. Prevalence varies according to different series. Clinical presentation is different in adults and infants. Although since its first descriptions several hypothesis have been elucidated, the aetiology is not quite clear. It is possible that different factors could be involved. PNALD risk factors can be classified (mas) in three groups: 1) those derived from the lack of enteral nutrition stimulus; 2) parenteral nutrition components acting as toxic or the lack of specific nutrients and 3) those due to the underlying disease. If PNALD appears in short-term PN and it presents only as a mild elevation of liver enzymes, there is no need to treat. On the contrary, when direct bilirubin is > 2 mg/dL and lasts longer, there is a need to consider different causes and to minimize risk factors. We review the different approaches to manage PNALD, including optimizing enteral nutrition, modify parenteral solutions, use of specific nutrients -taurine, choline, etc.- or the use of drugs (mainly ursodeoxicolic acid) If liver disease progresses to a cirrhosis a liver transplant must be considered.

Scientific Electronic Library Online (Spanish)

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Disfunción hepática en el trasplante de células progenitoras hematopoyéticas. Impacto sobre la mortalidad/ Liver dysfunction in recipients of hematopoietic stem cells. Impact on mortality

Cocozzella, Daniel; Méndez, Celina; Malacalza, Juliana; Adrover, Raúl; Borzi, Silvia; Saba, Silvia; Canepa, Carlos; Fraquelli, Emilio; Curciarello, José
2005-04-01

Resumen en español El compromiso hepático en receptores de trasplante alogénico de células progenitoras hematopoyéticas (TCPH) es una complicación muy frecuente y es responsable de la morbimortalidad precoz. La toxicidad por fármacos, la enfermedad injerto versus huésped (EICH), la enfermedad venooclusiva (EVO) y las infecciones fúngicas, bacterianas y virales constituyen las principales etiologías. El objetivo de este estudio retrospectivo fue establecer la prevalencia y etiologí (mas) a de la afectación hepática, evaluar el impacto en la mortalidad y analizar el valor predictivo de las transaminasas pre TCPH en la ocurrencia de EICH agudo, crónico y mortalidad. De un total de 236 pacientes trasplantados, se evaluaron 82 sometidos a TCPH alogénico. El 88% de los pacientes tuvo afectación hepática: EICH agudo 40.2%, EICH crónico 15.9%, de causa indeterminada 9.8%, sepsis 7.3%, toxicidad por fármacos 6.1%, EVO 3.7%, hepatitis aguda y recidiva de enfermedad 2.4%. La mortalidad evaluada al año fue 36.6%. La insuficiencia hepática aguda (IHA) representó el 10% de las muertes. Las causas de IHA fueron: progresión de EICH agudo, recidiva de la enfermedad hematológica en el hígado, hepatitis herpética y EVO. El valor predictivo positivo de las transaminasas pre TCPH para EICH agudo, crónico y mortalidad fue 0.27, 0.14 y 0.43 respectivamente. No se hallaron diferencias significativas entre pacientes con pruebas bioquímicas hepaticas pre TCPH alteradas o normales en la ocurrencia de EICH agudo, crónico o mortalidad. Resumen en inglés Liver disease is a well-known cause of early morbidity and mortality affecting 80% of patients receiving allogeneic bone-marrow transplantation (BMT). Drug toxicity, veno-occlusive disease (VOD), acute graft-versus-host disease (GVHD), and fungal, bacterial, and viral infections are the most frequent hepatic complications during this period. The aim of this retrospective study was to determine the prevalence and etiology of liver disease and its impact on mortality as wel (mas) l as to assess the predictive value of pre BMT hepatic biochemical tests on the subsequent occurrence of acute and/or chronic GVHD and patient mortality. Of a total of 236 patients who underwent allogeneic BMT, 82 were analysed. Liver dysfunction was found in 88%. The causes of liver disease were: acute GVHD, 40.2%; chronic GVHD, 15.9%; unknown, 9.8%; sepsis, 7.3%; hepatotoxicity, 6.1%; VOD, 3.7%; acute hepatitis and disease recurrence, 2.4%.The mortality rate was 37%. We found acute liver failure (ALF) in 10% of the deaths (8 patients). The causes of ALF in these cases were acute GVHD progression in 5, herpetic hepatitis in 1, disease recurrence in 1, and VOD in 1. The correlation coefficients indicating positive predictive values of pre BMT hepatic biochemical tests for the subsequent occurrence of acute GVHD, chronic GVHD, and mortality were 0.27, 0.14, and 0.43, respectively. There was no significant difference between patients with abnormal or normal pre BMT liver function tests in the frequency of acute and chronic GVHD or mortality.

Scientific Electronic Library Online (Spanish)

21

X-cell lesions in the liver of coho salmon Oncorhynchus kisutch

Dyková, Iva; Figueras, Antonio; Novoa, Beatriz
1993-04-01

Digital.CSIC (Spain)

22

Utilización del cobre en dietas hipograsas

Aguirre, M.; Navarro, María P.
1996-12-30

Digital.CSIC (Spain)

23

Use of vitellogenin mRNA as a biomarker for endocrine disruption in feral and cultured fish

García-Reyero, Natàlia; Raldúa, Demetrio; Quirós, Laia; Llaveria, Gisela; Cerdá, Joan; Barceló, Damià; Grimalt, Joan O.; Piña, Benjamín
2004-02-04

Digital.CSIC (Spain)

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26

Tumor renal con invasión hepática: aportación de un nuevo caso y revisión de la literatura/ Renal cell carcinoma with liver extension: a report of a new case and literature review

Quicios Dorado, C.; Mayayo Dehesa, T.; Nuño Vázquez-Gaza, J.; García Teruel, D.; López Buenadicha, A.; Díez Nicolás, V.
2007-05-01

Resumen en español El carcinoma de células renales (CCR) con invasión directa de órganos adyacentes es un hallazgo infrecuente y de mal pronóstico en el que el único tratamiento potencialmente efectivo es la cirugía radical. Se presenta el caso de una mujer con gran masa renal y afectación hepática y diafragmática sometida a tratamiento quirúrgico, y se realiza revisión de la literatura. Resumen en inglés Locally advanced renal cell carcinoma (RCC) with involvement to adjacent organs is uncommon and the prognosis is poor. Radical surgery remains the only effective treatment. We report the case of a woman with RCC and direct liver extension who was surgically treated. A literature review is made.

Scientific Electronic Library Online (Spanish)

27

Trasplante hepático/ Liver transplantation

Herrero, J. I.; Pardo, F.; Quiroga, J.; Rotellar, F.
2006-08-01

Resumen en español El trasplante hepático es una opción terapéutica eficaz para las enfermedades hepáticas terminales. Las principales indicaciones del trasplante hepático son la cirrosis hepática, los tumores hepáticos (fundamentalmente, el hepatocarcinoma) y la insuficiencia hepática aguda grave. Con el paso de los años, las contraindicaciones absolutas para el trasplante se han ido reduciendo. La técnica quirúrgica también ha sufrido modificaciones. Los resultados del traspla (mas) nte hepático han mejorado, de forma que la supervivencia al año del trasplante está próxima al 90% y a los cinco años, un 80% de los pacientes trasplantados siguen vivos. Resumen en inglés Liver transplantation is an efficient therapeutic option for terminal hepatic diseases. The principal indications of liver transplantation are hepatic cirrhosis, hepatic tumours (mainly, hepotocellular carcinoma) and acute liver failure. Over the years, the absolute contraindications for a transplant have lessened. Surgical techniques have also undergone changes. The results of liver transplant have improved so that survival one year after the transplant is close to 90% and after five years some 80% of transplanted patients continue to live.

Scientific Electronic Library Online (Spanish)

28

Trasplante hepático en Chile: Aspectos generales, indicaciones y contraindicaciones (Documento de consenso)/ General considerations, indications and contraindications for liver transplantation in Chile: A multicenter consensus development document

Hepp, Juan; Zapata, Rodrigo; Buckel, Erwin; Martínez, Jorge; Uribe, Mario; Díaz, Juan Carlos; Ferrario, Mario; Sanhueza, Edgar; Pérez, Rosa María; Hunter, Bessie; Ríos, Gloria; Humeres, Roberto; Poniachik, Jaime; Oksenberg, Danny; Arrese, Marco
2008-06-01

Resumen en inglés Liver transplantation is an excellent therapeutic option for terminal liver disease. During the last decades the results of liver transplantation have improved significantly with a patient survival rate of nearly 90% at one year and 80% at 5 years of follow-up. The main indications for liver transplantation include: end-stage liver disease associated to cirrhosis, acute liver failure, and hepatic tumors (mainly hepatocarcinoma). The absolute contraindications for a transp (mas) lant are less frequent than in the past, and include: severe co-morbidity (cardiac or pulmonary), sepsis, advanced HIV disease and extra-hepatic malignancy. This document presents a Consensus of the main groups performing liver transplantation in Chile, about its indications and contraindications. It also reviews general aspects of liver transplantation, including the selection and referral of liver transplant candidates, allocation of organs and the evaluation of severity of liver disease

Scientific Electronic Library Online (Spanish)

29

Trasplante combinado hepato-renal: a propósito de un caso/ Combined liver-kidney transplantation: Report of one case

Roque E, Jorge; Ríos M, Gloria; Hepp K, Juan; Innocenti C, Franco; Humeres A, Roberto; Palacios J, José M; Ríos R, Horacio; Suárez P, Leopoldo; Contreras M, María Angélica; Rius A, Montserrat
2003-11-01

Resumen en inglés End stage renal disease is not an absolute contraindication for liver transplantation (LT) in patients with end stage liver disease. Actuarial patient and graft survival are comparable for children and adults who undergo LT alone and liver-kidney transplantation (LKT). The most common indications for LKT are the primary hyperoxaluria type I (PH1) and the liver and renal polycystic disease. We report a 12 years old boy with congenital hepatic fibrosis with severe portal hy (mas) pertension, encephalopathy and polycystic kidney disease with end stage renal disease on dialysis that underwent LKT. During the second postoperative week, he had a biopsy-proven acute liver and renal rejection, that had a good response to corticosteroids. Thirty days after surgery, the liver biopsy was without rejection. No other complications were observed (Rev Méd Chile 2003; 131: 1309-12)

Scientific Electronic Library Online (Spanish)

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Toxicidad hepática recurrente secundaria a metilprednisolona intravenosa/ Recurrent acute liver toxicity from intravenous methyprednisolone

Rivero Fernández, M.; Riesco, J. M.; Moreira, V. F.; Moreno, A.; López San Román, A.; Arranz, G.; Ruiz del Árbol, L.
2008-11-01

Resumen en español Las reacciones adversas hepáticas relacionadas con la administración de fármacos (hepatotoxicidad) son cuadros relativamente frecuentes que presentan una amplia variabilidad clínica e histológica. La identificación precoz de estos cuadros es fundamental en la práctica clínica debido a su potencial gravedad. En la mayoría de los casos la suspensión del fármaco desencadenante es suficiente para la resolución del cuadro clínico. A pesar de que los esteroides son (mas) utilizados en una amplia variedad de situaciones clínicas, la notificación de cuadros de hepatotoxicidad secundaria a esteroides intravenosos es excepcional. Presentamos el caso clínico de una mujer diagnosticada de esclerosis múltiple, que recibió metilprednisolona a altas dosis en forma de "pulsos" intravenosos como tratamiento de las reagudizaciones de su enfermedad y presentó 3 brotes recurrentes de hepatitis de predominio hepatocelular con un patrón clínico, analítico e histológico compatible con toxicidad hepática aguda secundaria a metilprednisolona intravenosa. En el tercer episodio se realizó una biopsia hepática que demostró un patrón de hepatitis aguda con necrosis líticas confluentes, histología no descrita previamente en pacientes tratados con esteroides intravenosos. Resumen en inglés Adverse drug reactions (hepatotoxicity) are a frequent cause of acute liver injury with a wide clinical and histological spectrum. An early recognition of drug-related liver disease has been considered essential in clinical practice due to potential risks. In most cases exposure discontinuation improves the clinical picture. Steroids are used in a variety of clinical settings. However, intravenous steroids have rarely been associated with hepatotoxicity. We report the cas (mas) e of a middle-aged woman with multiple sclerosis who received a bolus of methylprednisolone on three occasions for the management of relapsing disease, with the development of repeated episodes of elevated liver enzymes after corticoid administration. In the third episode a liver biopsy was performed, which showed acute hepatitis with bridging necrosis; such histological picture has not been described before in patients treated with intravenous steroids.

Scientific Electronic Library Online (Spanish)

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Tolerancia y quimerismo en el trasplante hepático/ Tolerance and chimerism in liver transplantation

Pons Miñano, J. A.; Ramírez Romero, P.; Robles Campos, R.; Sánchez Bueno, F.; Parrilla Paricio, P.
2007-06-01

Scientific Electronic Library Online (Spanish)

32

Thyroid hormone regulates tubulin expression in mammalian liver. Effects of deleting thyroid hormone receptor-alpha or -beta

Vallejo, Carmen G.; Seguido, Ana M.; Testillano, Pilar S.; Risueño, María del Carmen
2005-07-01

Digital.CSIC (Spain)

33

Therapeutic targets in liver transplantation: angiotensin II in nonsteatotic grafts and angiotensin-(1-7) in steatotic grafts

Alfany-Fernández, Izabel; Casillas-Ramírez, Araní; Bintanel-Morcillo, Maria; Brosnihan, K.B.; Ferrario, C.M.; Serafín, Anna; Rimola, Antoni; Rodés, Joan; Roselló Catafau, Joan; Peralta, Carmen
2009-02-03

Digital.CSIC (Spain)

36

The Epithelial Mesenchymal Transition Confers Resistance to the Apoptotic Effects of Transforming Growth Factor β in Fetal Rat Hepatocytes

Valdés, Francisco; Álvarez, Alberto M.; Locascio, Annamaria; Vega, Sonia; Herrera, Blanca; Fernández, Margarita; Benito, Manuel; Nieto, M. Ángela; Fabregat, Isabel
2002-01-01

Digital.CSIC (Spain)

38

TNFalpha-Polymorphismus bei Patienten mit Sepsis und Schilddrüsenkarzinomen

Rossbach, Christiane

Das Zytokin Tumornekrosefaktor a (TNFa) hat einen entscheidenden Anteil an der Entwicklung schwerer Komplikationen, wie septischer Schock und Multiorganversagen nach Entwicklung einer Sepsis. Eine Assoziation des TNF2-Allels mit einem erhöhten TNF a Spiegel und einer höheren Mortalitätsrate wurde i...

DRIVER (Spanish)

39

Sublethal toxicity of the Prestige oil spill on yellow-legged gulls

Alonso-Álvarez, Carlos; Munilla, Ignacio; López-Alonso, Marta; Velando, Alberto

9 pages. | The Prestige oil spill in November 2002 is considered the biggest large-scale catastrophe of its type in Europe, thousands of seabirds dying in the subsequent months. Here, the total concentration of 16 polycyclic aromatic hydrocarbons (TPAH) was measured in the blood cell fraction of adu...

DRIVER (Spanish)

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41

Structural aspects on rat liver S-adenosylmethionine synthesis

Pajares, María A.; Gasset, María; Sanz-Aparicio, Juliana; Calvete, Juan J.; Arrondo, José Luis R.

Methionine adenosyltransferase is the enzyme that catalyzes the synthesis of S-adenosylmethionine. In mammals three isoenzymes have been purified, two of which. MAT III and I, are products of the same gene MAT1A, but differ in their kinetic constants and oligomerization state. Changes in activity an...

DRIVER (Spanish)

42

Structural aspects on rat liver S-adenosylmethionine synthesis

Pajares, María A.; Gasset, María; Sanz-Aparicio, Juliana; Calvete, Juan J.; Arrondo, José Luis R.
2003-01-01

Digital.CSIC (Spain)

43

Site-directed mutagenesis of rat liver S-adenosylmethionine synthetase. Identification of a cysteine residue critical for the oligomeric state

Mingorance, Jesús; Álvarez, Luis; Sánchez-Góngora, Estrella; Mato, José M.; Pajares, María A.
1996-05-01

Digital.CSIC (Spain)

44

Sex hormone-binding globulin expression in sea bass (Dicentrarchus labrax L.) throughout development and the reproductive season

Miguel-Queralt, Solange; Blázquez, Mercedes; Piferrer, Francesc; Hammond, Geoffrey L.
2007-07-19

Digital.CSIC (Spain)

45

Selección del receptor para trasplante hepático/ Recipient selection for liver transplantation

Vilatobá, Mario; Eckhoff, Devin E.; Contreras, Juan Luis
2005-04-01

Resumen en español En los últimos años han existido avances importantes en el trasplante hepático. La evolución en la cirugía hepática y la aparición de mejores inmunosupresores han incrementado de manera importante el éxito en el trasplante hepático. Este éxito ha aumentado el número de receptores; sin embargo, al mismo tiempo el número de órganos ha permanecido estable en los últimos 10 años, teniendo como resultado un incremento en la disparidad entre donadores y receptore (mas) s. Por lo tanto es necesario conocer quiénes son los mejores candidatos para un trasplante hepático. En este artículo se revisarán las indicaciones y contraindicaciones en el trasplante hepático en la era de la clasificación de MELD (por sus siglas en inglés Model for End Stage Liver Disease). Resumen en inglés In the last few years, there have been developments In many aspects of liver transplantation. Improvements in surgical techniques and immunosuppression markedly increased the success rates of liver transplantation. This success has lead to increasing numbers of recipients. However, the availability of cadaveric organs for transplantation has not been changed in the last 10 years, resulting in a growing discrepancy between donors and recipients. Thus, it is necessary to pr (mas) operly select the best candidates for a successful liver transplant. This article will review the indications and contraindications for liver transplantation in the Model for End Stage Liver Disease (MELD) score era.

Scientific Electronic Library Online (Spanish)

47

S6K1 deficiency protects against apoptosis in hepatocytes

González-Rodriguez, Águeda; Alba, Javier; Zimmerman, Valeri; Kozma, Sara C.; Martínez Valverde, Ángela

14 pages, 8 figures.-- PMID: 19437488 [PubMed].-- Article in press. | The mammalian target of rapamycin (mTOR)/S6K1 signaling pathway controls cell growth and proliferation. To assess the importance of S6K1 in the balance between death and survival in the liver, we have generated immortalized hepato...

DRIVER (Spanish)

48

S6K1 deficiency protects against apoptosis in hepatocytes

González-Rodríguez, Águeda; Alba, Javier; Zimmerman, Valeri; Kozma, Sara C.; Martínez Valverde, Ángela
2009-02-18

Digital.CSIC (Spain)

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50

Riesgo perioperatorio en pacientes con cirrosis hepática/ Perioperative risk among patients with cirrhosis

CONCHA P, MARIO; MERTZ K, VERÓNICA
2010-09-01

Resumen en inglés Ten percent of cirrhotic patients with severely compromised liver function will require a surgical procedure. This article reviews the surgical risk associated with liver damage and surgery. The most important prognostic factor is the degree of functional impairment of the liver. It is evaluated using the Child-Pugh score, which has limitations that have been partially overcome by the Model for End Stage Liver Disease (MELD) score. Cardiac surgery has the highest risk, wh (mas) ile extra-thoracic and extra-abdominal procedures have the lowest risk. The mortality for abdominal surgery fluctuates between 11 and 76%. Biliary surgery is associated with frequent complications and mortality, which seem to decrease when the procedures are laparoscopic. There are few series that evaluate risk in Child C patients. In liver resective surgery, liver function impairment and magnitude of the excision determine the risk. A high serum creatinine, cardiac failure and emergency surgery are independent risk factors. Although MELD score is useful to predict surgical risk, decision-making must be based on an individualized evaluation of each patient and careful planning of surgical procedures

Scientific Electronic Library Online (Spanish)

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Resultados del tratamiento quirúrgico de las metástasis hepáticas por cáncer colorrectal/ Outcome of surgical treatment of liver metastasis from colorectal cancer

Norero, Enrique; Jarufe, Nicolás; Butte, Jean M; Norero, Blanca; Duarte, Ignacio; Torres, Javiera; Pinedo, George; López, Francisco; Guerra, Juan Francisco; Ibáñez, Luis; Zúñiga, Álvaro; Guzmán, Sergio; Martínez, Jorge
2009-04-01

Resumen en inglés Background: Surgical resection is the only treatment associated with long-term cure in patients with liver metastasis from colorectal cancer, achieving a 30% to 40% five years survival. Aim: To evaluate the results of liver resection for metastatic colorectal cancer in our centre. Patients and methods: Retrospective study. Epidemiological, perioperative and follow up data of patients undergoing liver resection for metastatic colorectal cancer between January 1990 and July (mas) 2007 were assessed. We compared the results between two periods; period 1 (1990-1997) and period 2 (1998-2007). Results: Sixty six patients aged 61± 12 years (46 males) underwent 75 resections. An anatomical excision was performed in 54 (72%) cases, a right hepatectomy in 18, an extended right hepatectomy in 11, a left hepatectomy in 1, and a segmentectomy in 24. In 24 (32%) patients the liver resection was simultaneous with the colorectal cancer resection. Operative time was 221±86 min. Hospital stay was 11±5 days. Postoperative morbidity was 35% and surgical mortality was 0%. Resection margin was free of tumor in 53 (80%) patients. Five years overall and hepatic disease-free survival was 38% and 23%, respectively. In period 2, more anatomical resections than in period 1 were performed (77% and 55%, respectively, p =0.04), without an increase in complications (35% and 34%, respectively; p =ns), but with a better five years survival (45% and 21 %, respectively, p =0.04). Conclusions: Five years survival for excision of liver metastatic colorectal cancer in our center is similar to that reported abroad. During the second period there has been a trend toward more extensive resections which was associated with a better survival, without an increase in complications or mortality

Scientific Electronic Library Online (Spanish)

52

Research and development of a new RF-assisted device for bloodless rapid transection of the liver: Computational modeling and in vivo experiments

Burdío, Fernando; Berjano, Enrique J.; Navarro, Ana; Burdío, José M.; Grande, Luis; Subirá, Jorge; Castiella, Tomás

DRIVER (Spanish)

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Research and development of a new RF-assisted device for bloodless rapid transection of the liver: Computational modeling and in vivo experiments

Burdío, Fernando; Berjano, Enrique J.; Navarro, Ana; Burdío, José M.; Grande, Luis; Subirá, Jorge; Castiella, Tomás; Poves, Ignasi; Lequerica, Juan L.
2009-03-18

Digital.CSIC (Spain)

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55

Repeated Oral Administration of High Doses of the Pomegranate Ellagitannin Punicalagin to Rats for 37 Days Is Not Toxic

Cerdá, Begoña; Cerón, José J.; Tomás Barberán, Francisco; Espín de Gea, Juan Carlos
2003-04-22

Digital.CSIC (Spain)

56

Redox control of liver function in health and disease

Marí, Montserrat; Colell, Anna; Morales, Albert; Montfort, Claudia von; Garcia-Ruiz, Carmen; Fernández-Checa, José C.
2010-06-01

Digital.CSIC (Spain)

57

Recurrencia de la enfermedad hepática primaria después del trasplante hepático/ Liver disease recurrence after liver transplantation

RAKELA B, JORGE
2010-04-01

Resumen en inglés Liver transplantation has become a standard option in the management of patients with end-stage liver disease. It is now evident that the most common etiology of long-term graft dysfunction is the recurrence of the primary liver disease. Autoimmune liver disorders such as autoimmune hepatitis, primary biliary cirrhosis, and primary sclerosing cholangitis recur between 15 to 30% of the graft recipients. The clinical expression of this recurrence tends to be milder; the dia (mas) gnosis is only established in many patients by fndings in the liver biopsy. This milder clinical expression may be due to the use of immunosuppressive therapy for the prevention of organ rejection and it may also be modulating immune mechanisms that underlie these conditions. The recurrence of hepatitis C virus infection is characterized by an accelerated progression towards cirrhosis and hepatic failure due to the lack of an effective immunoprophylaxis program and an effective antiviral therapy. The recurrence of hepatitis B is uncommon due to the availability on an effective immunoprophylaxis program with effective antiviral agents. The familial amyloidotic polyneuropathy is a genetic condition residing in the hepatocyte that produces a mutation of transthyretin; this abnormal protein is deposited in peripheral nerves, gastrointestinal tract, heart, and kidneys. The liver from these patients, apart from producing this abnormal protein, is otherwise normal, and has been used as an organ for recipients in dire need of a liver transplant, such as patients with hepatocellular carcinoma. This approach is known as “domino” liver transplantation. As these recipients are followed long term, they may develop de novo amyloidosis. In summary, the underlying liver condition that led to endstage liver disease and liver transplantation may recur after liver transplantation. The clinical expression of the recurrence of the hepatic disease is modulated by the immunosuppression program unless we have an effective immunoprophylaxis and antiviral agents such as in hepatitis B

Scientific Electronic Library Online (Spanish)

58

Reactive oxygen species mediate liver injury through parenchymal nuclear factor-kappaB inactivation in prolonged ischemia/reperfusion.

Llacuna, Laura; Marí, Montserrat; Lluis, Josep M.; García Ruiz, Carmen; Fernández Checa, José C.; Morales, Albert
2009-05-01

Digital.CSIC (Spain)

59

Rat liver betaine-homocysteine S-methyltransferase equilibrium unfolding: insights into intermediate structure through tryptophan substitutions

Garrido, Francisco; Gasset, María; Sanz-Aparicio, Juliana; Alfonso, Carlos; Pajares, María A.
2005-11-01

Digital.CSIC (Spain)

60

Radiofrecuencia laparoscópica de lesión focal hepática de origen colorrectal/ Laparoscopic radiofrequency of a liver focal lesion of colorrectal origin

Pérez-Robledo, J. P.; Prieto-Nieto, M. I.; Olveira, A.; Martí de Gracia, M.; Erdozain, J. C.; Carrión, G.; Segura, J. M.; Rodríguez-Montes, J. A.; García-Sancho Martín, L.
2008-04-01

Scientific Electronic Library Online (Spanish)

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Quimioembolización hepática en el manejo terapéutico del hepatocarcinoma: Reporte de dos casos/ Chemoembolization of hepatocarcinoma: Report of two cases

Fava, Mario; Meneses, Luis; González, Robinson; Loyola, Soledad
2008-04-01

Resumen en inglés Chemoembolization is a therapeutic alternative for those patients with hepatocarcinoma that cannot be excised surgically or that are waiting a liver allograft. We report two patients with hepatocarcinoma who were subjected to chemoembolization. A 65 years old male with a chronic liver disease and right lobe hepatocarcinoma, waiting for a liver transplantation, was subjected to two sessions, of chemoembolization four weeks apart. A magnetic resonance showed a 80% reduction (mas) of tumor volume one month later. A 72 years old diabetic male with an alcoholic liver disease with two hepatocarcinoma in the right lobe was subjected to two sessions of chemoembolization, separated by four weeks. A magnetic resonance one month later showed the absence of blood flow in both lesions, suggesting complete necrosis

Scientific Electronic Library Online (Spanish)

63

Putative prethymic T cell precursors within the early human embryonic liver: a molecular and functional analysis

Sánchez, María J.; Gutiérrez Ramos, José Carlos; Fernández, Edgar; Leonardo, Esther; Lozano, Juanjo

El copyright pertenece a The Rockefeller University Press | Hematopoietic cells present in the liver in early human fetal life were characterized by phenotypic analysis using a broad panel of monoclonal antibodies. Expression of very late antigen 4 and leukocyte function-associated antigen 3 cell ad...

DRIVER (Spanish)

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Putative prethymic T cell precursors within the early human embryonic liver: a molecular and functional analysis

Sánchez, María J.; Gutiérrez Ramos, José Carlos; Fernández, Edgar; Leonardo, Esther; Lozano, Juan José; Martínez-Alonso, Carlos; Toribio, María Luisa
1993-01-01

Digital.CSIC (Spain)

65

Protein recycling in growing rabbits: contribution of microbial lysine to amino acid metabolism

Belenguer, Álvaro; Balcells, Joaquín; Guada, Jose A.; Decoux, Marc; Milne, Eric
2005-01-01

Digital.CSIC (Spain)

67

Protein kinase C catalyses the phosphorylation and activation of rat liver phospholipid methyltransferase

Villalba, Mayte; Pajares, María A.; Renart, Marga F.; Mato, José M.
1987-02-01

Digital.CSIC (Spain)

68

Protection by nitric oxide against liver inflammatory injury in animals carrying a nitric oxide synthase-2 transgene

Mojena, Marina; Hortelano, Sonsoles; Castrillo, Antonio; Díaz-Guerra, María José; García-Barchino, María J.; Sáez, Guillermo T.; Boscá, Lisardo
2001-03-01

Digital.CSIC (Spain)

69

Protection against Fas-induced liver apoptosis in transgenic mice expressing cyclooxygenase 2 in hepatocytes

Casado, Marta; Mollá, Belén; Roy, Rosa; Fernández-Martínez, Amalia; Cucarella, Carme; Mayoral, Rafael

The definitive version is available at http://www3.interscience.wiley.com/journal/114130115/abstract | Cyclooxygenase-2 (COX-2) is upregulated in many cancers, and the prostanoids synthesized increase proliferation, improve angiogenesis, and inhibit apoptosis in several tissues. To explore the funct...

DRIVER (Spanish)

70

Protection against Fas-induced liver apoptosis in transgenic mice expressing cyclooxygenase 2 in hepatocytes

Casado, Marta; Mollá, Belén; Roy, Rosa; Fernández-Martínez, Amalia; Cucarella, Carme; Mayoral, Rafael; Boscá, Lisardo; Martín-Sanz, Paloma
2007-02-26

Digital.CSIC (Spain)

71

Prospects for the utilization of Ray as canned product

Pastoriza, Laura; Sampedro, Gabriel
1993-01-01

Digital.CSIC (Spain)

74

Preliminary protective capacity study of a Dicrocoelium dendriticum antigenic protein in hamsters

González Lanza, Camino; Manga-González, M. Yolanda; Revilla-Nuín, Beatriz

4 pages, 2 tables.-- PMID: 16738887 [PubMed].--Available online 1 Jun 2006. | The purpose of this study was to evaluate the protective capacity of 130 kDa Dicrocoelium dendriticum protein in hamsters experimentally infected with this parasite. Forty hamsters divided into four groups of ten animals e...

DRIVER (Spanish)

76

Polycyclic aromatic hydrocarbons in fish from remote and high mountain lakes in Europe and Greenland

Vives, Ingrid; Grimalt, Joan O.; Fernández Ramón, M. Pilar; Rosseland, B. O.
2004-05-25

Digital.CSIC (Spain)

77

Polybromodiphenyl ether flame retardants in fish from lakes in European high mountains and Greenland

Vives, Ingrid; Grimalt, Joan O.; Lacorte Bruguera, Silvia; Guillamón, Miriam; Barceló, Damià
2004-03-16

Digital.CSIC (Spain)

78

Poliquistosis hepática/ Polycystic liver disease

Campos Franco, J.; Otero Antón, E.; Gamborino Caramés, E.; Martínez Castro, J.; Varo Pérez, E.
2009-04-01

Scientific Electronic Library Online (Spanish)

79

Physiological response to persistent organic pollutants in fish from mountain lakes: analysis of CYP1A gene expression in natural populations of Salmo trutta

Quirós, Laia; Jarque, Sergio; Reinhard, Lackner; Fernández Ramón, M. Pilar; Grimalt, Joan O.; Piña, Benjamín

7 pages, 3 figures.-- PMID: 17711238 [PubMed].-- Printed version published on Jul 15, 2007. | Cytochrome p450 1A (CYP1A) gene expression in fish liver increases upon exposure to a variety of chemical compounds, including organochlorine compounds (OCs) and polycyclic aromatic hydrocarbons (PAHs). To ...

DRIVER (Spanish)

81

Peliosis hepática focal: Caso clínico radiológico/ Peliosis hepatis: Report of one case

MIRANDA, ROBERTO; STAMBUK, JUAN; VIAL, MARÍA TERESA; MIRANDA, ANDRÉS
2010-09-01

Resumen en inglés Peliosis hepatis is a rare vascular condition of the liver characterized by the presence of cystic blood-fi lled cavities distributed randomly throughout the liver parenchyma. We report a 46 year old female, with dyspepsia. An abdominal Doppler ultrasound showed a hyper vascularized solid liver nodule of 5 cm diameter. Magnetic resonance imaging and CT scan showed the same hyper vascularized nodule. With the possible diagnoses of primary hepatocellular carcinoma or focal (mas) nodular hyperplasia, the patient was subjected to an excision of hepatic segment VI, where the nodule was located. The pathological diagnosis of the surgical piece was a peliosis hepatis

Scientific Electronic Library Online (Spanish)

82

Participación del óxido nítrico durante el desarrollo del absceso hepático amebiano/ Nitric oxide participation during amoebic liver abscess development

Ramírez-Emiliano, Joel; Flores-Villavicencio, Lérida Liss; Segovia, José; Arias-Negrete, Sergio
2007-04-01

Resumen en español El óxido nítrico participa en funciones fisiológicas y fisiopatológicas, así como en el mecanismo de defensa del sistema inmunológico de mamíferos contra parásitos, virus y bacterias. La Entamoeba histolytica es un parásito protozoario causante de la amebiasis, la cual se caracteriza por el daño intestinal y la formación del absceso hepático amebiano (AHA). El desarrollo del absceso hepático amebiano en el hámster es similar al que desarrolla el humano, mien (mas) tras que el ratón es resistente a la formación de este absceso, debido a un incremento en la producción de óxido nítrico. A diferencia del ratón, el desarrollo del absceso hepático amebiano en el hámster es debido a un exceso en la producción de óxido nítrico o posiblemente a una mayor susceptibilidad del hámster al daño producido por el óxido nítrico. Por lo tanto, sería importante realizar más estudios para determinar si en el humano, un exceso en la producción de óxido nítrico favorece la formación del absceso hepático amebiano. Resumen en inglés Nitric oxide participates in both physiological and pathophysiological functions, and it plays an important role in the mammalian immune system in killing or inhibiting the growth of many pathogens, including parasites, viruses and bacteria. Entamoeba histolytica is a protozoan parasite that causes amoebiasis, which is characterized by intestinal damage and amoebic liver abscess development. The development of amoebic liver abscess in hamsters is similar to that in humans (mas) , whereas mice are resistant to amoebic liver abscess development due to an increase in nitric oxide production. Unlike in mice, amoebic liver abscess development in hamsters is due to an excess in nitric oxide production or possibly to a greater susceptibility of the hamster to damage caused by nitric oxide. Therefore, it could be important to elucidate if, in humans, an excess in nitric oxide production favors amoebic liver abscess development.

Scientific Electronic Library Online (Spanish)

83

PTP1B deficiency increases glucose uptake in neonatal hepatocytes: involvement of IRA/GLUT2 complexes

González-Rodríguez, Águeda; Nevado, Carmen; Escrivá, Fernando; Sesti, Giorgio; Rondinone, Cristina M.; Benito, Manuel; Valverde, Ángela M.
2008-08-01

Digital.CSIC (Spain)

84

Oxidative Stress in Rat Retina and Hippocampus after Chronic MDMA (‘ecstasy’) Administration

Miranda, María; Bosch Morell, Francisco; Johnsen Soriano, Siv; Barcia, Jorge; Almansa, Inmaculada; Asensio, Samuel; Araiz, Javier; Messeguer Peypoch, Àngel; Romero, Francisco. J.
2007-03-31

Digital.CSIC (Spain)

85

Organochlorine compounds in liver and concentrations of vitellogenin and 17β-estradiol in plasma of sea bass fed with a commercial or with a natural diet

Navas, José María; Merino, Rubén; Jiménez, Begoña; Rivera, Josep; Abad Holgado, Esteban; Zanuy, Silvia; Carrillo, Manuel
2005-10-06

Digital.CSIC (Spain)

86

Nutrición artificial en la insuficiencia hepática/ Artificial nutrition in liver failure

Jiménez Jiménez, F. J.; Montejo González, J. Carlos; Nuñez Ruiz, R.
2005-06-01

Resumen en español El soporte nutricional y metabólico de los pacientes con insuficiencia hepática debería ser capaz de aportar adecuadamente los requerimientos nutricionales y, al mismo tiempo, contribuir a la recuperación de los pacientes mediante el control o la reversión de las alteraciones metabólicas apreciadas. No obstante, a pesar de la base fisiopatológica, clásicamente descrita por algunos autores, que considera al disbalance de aminoácidos un factor desencadenante y mant (mas) enedor de la encefalopatía, no existen datos suficientes para recomendar el empleo de soluciones específicas (enriquecidas en aminoácidos ramificados y pobres en aminoácidos aromáticos) como parte del soporte nutricional en los pacientes con insuficiencia hepática aguda. Tampoco se recomienda su empleo rutinario como prevención de complicaciones en los pacientes sometidos a trasplante hepático. Como en otros pacientes críticos, la vía de aporte de nutrientes debe ser la enteral, siempre que ello sea posible. No se recomienda el empleo de dietas específicas de insuficiencia hepática sino que la composición de nutrientes debe estar adaptada a la situación de estrés metabólico. En los pacientes que requieran nutrición parenteral, no existe contraindicación para el empleo de infusiones lipídicas. Se recomienda un incremento en el aporte de vitaminas y de oligoelementos. En los pacientes sometidos a trasplante hepático, el aporte de nutrientes debería iniciarse de manera precoz en el postoperatorio mediante una vía de acceso transpilórica. Resumen en inglés Nutritional and metabolic support in patients with liver failure should be able to adequately provide the nutritional requirements and, at the same time, to contribute in patients' recovery by controlling or reverting the metabolic impairments observed. However, in spite of the pathophysiologic basis described by some authors considering amino acids unbalance as a triggering and maintaining factor for encephalopathy, there are no sufficient data to recommend the use of sp (mas) ecific solutions (branched amino acids-enriched and low on aromatic amino acids) as part of the nutritional support of patients with acute liver failure. Its routinary use is neither recommended for preventing complications in patients submitted to liver transplantation. As with other critically ill patients, the nutrients administration route should be the enteral route, whenever possible. The use of liver failure specific diets is not recommended; on the contrary, nutrients composition must be adapted to the metabolic stress condition. In patients requiring parenteral nutrition, there is no contraindication to the use of lipid infusions. An increase in vitamins and micronutrients intake is recommended. In patients submitted to liver transplantation, nutrients intake should be started early in the postoperative period through a transpyloric route of access.

Scientific Electronic Library Online (Spanish)

87

Nuclear factor kappaB is required for the transcriptional control of type II NO synthase in regenerating liver

Díaz-Guerra, María José; Velasco, Marta; Martín-Sanz, Paloma; Boscá, Lisardo
1997-09-15

Digital.CSIC (Spain)

88

Necrosis hepática secundaria a intoxicación por organofosforados/ Liver necrosis secondary to organophosphates intoxication

Adán Merino, L.; Gómez Senent, S.; Gea Rodríguez, F.; Alonso Gamarra, E.; Martín Arranz, E.; Segura Cabral, J. M.
2010-04-01

Scientific Electronic Library Online (Spanish)

90

Natural trans-splicing in carnitine octanoyltransferase pre-mRNAs in rat liver

Caudevilla, Concha; Serra, Dolors; Miliar, Angel; Codony, Carles; Asins, Guillermina; Bach, Montserrat; Hegardt, Fausto G.
1998-10-13

Digital.CSIC (Spain)

91

Natural infection of Lymnaea truncatula by the liver fluke Fasciola hepatica in the Porma Basin, León, NW Spain.

Manga-González, M. Yolanda; González Lanza, Camino; Otero-Merino, Cristina B.

http://www.ncbi.nlm.nih.gov/pubmed/2050981 | For two years fortnightly malacological samplings were carried out to collect Lymnaea truncatula (Mollusca; Basommatophora) at five points in the upper and middle Porma river basin, León, Spain. The highest numbers of snails were collected in September, M...

DRIVER (Spanish)

92

Molecular studies on Dicrocoelium dendriticum

Sandoval, Hilda; Manga-González, M. Yolanda
1996-01-01

Digital.CSIC (Spain)

93

Molecular Characterization and Expression Pattern of Zona Pellucida Proteins in Gilthead Seabream (Sparus aurata)

Modig, Carina; Modesto, Teresa; Canário, Adelino V. M.; Cerdà, Joan; von Hofsten, Jonas; Olsson, Per-Erik
2006-01-01

Digital.CSIC (Spain)

94

Modulation of liver antioxidant ability under chronic fascioliasis and (ZnxCu(1-x))2(OH)3Cl supplementation

Gabrashanska, M.; Manga-González, M. Yolanda; Misinska, Y.; Ermidou-Pollet, S.; Pollet, S.

6 pages, 4 tables. | [Aim] The aim of this study was to assess the antioxidant status (vitamin C, E, A, zinc, copper, superoxide dismutase, catalase, glutathione peroxidase and malondialdehyde) of rat liver in chronic stage of fasciolosis after treatment with Zn-Cu mixed basic salt. | [Methods] Whit...

DRIVER (Spanish)

95

Modulation of liver antioxidant ability under chronic fascioliasis and (ZnxCu(1-x))2(OH)3Cl supplementation

Gabrashanska, M.; Manga-González, M. Yolanda; Misinska, Y.; Ermidou-Pollet, S.; Pollet, S. A.
2007-01-01

Digital.CSIC (Spain)

96

Modulation of liver antioxidant ability under chronic fasciliasis and (Znx Cu1-x)2 (OH) 3C1

Gabrashanska, M.; Manga-González, M. Yolanda; Mizinska, Y.; Ermidou-Pollet, S.; Pollet, S.
2006-01-01

Digital.CSIC (Spain)

97

Modelos de pronóstico en enfermedad hepática Child & Meld

Bohórquez, Humberto E; Beltrán Gálvis, Oscar Alfredo
2004-06-01

Resumen en español Los modelos pronósticos en la enfermedad hepática son fundamentales, desde que el trasplante hepático dejó de ser un procedimiento experimental y se convirtió en una opción terapéutica. Se revisan los modelos propuestos para estimar un pronóstico en las enfermedades hepáticas. El Child-Turcotte-Pugh es la clasificación mas conocida y utilizada en la evaluación pronóstica de los pacientes cirróticos, pero tiene sus limitaciones como la subjetividad de algunos (mas) parámetros clínicos y su capacidad de discriminación. El sistema MELD/PELD es una medida mas objetiva para evaluar la severidad en los pacientes con cirrosis hepática y en la asignación de órganos para trasplante hepático . Resumen en inglés The prognostic models are basic in the liver disease, since the liver transplantation has evolved from a experimental procedure to an accepted treatment for end-stage liver disease. We evaluated the role de prognostic models in the liver diseases. The Child-Turcotte-Pugh is still considered cornerstone in the prognostic evaluation of cirrhotic patients Nevertheless, it has some drawbacks such a subjectivity of clinical parameters and limited discriminant ability. The MELD (mas) score (model for end-stage-liver -disease) is a reliable measure to determine of mortality risk and to asses a disease severity in patients vith liver cirrhosis so as to determine organ allocation priorities.

Scientific Electronic Library Online (Spanish)

98

Mitochondrial S-adenosyl-L-methionine transport is insensitive to alcohol-mediated changes in membrane dynamics

Fernández, Anna; Colell, Anna; Caballero, Francisco; Matías, Nuria; Fernández-Checa, José C.
2009-04-09

Digital.CSIC (Spain)

99

Mice with targeted disruption of p8 gene show increased sensitivity to lipopolysaccharide and DNA microarray analysis of livers reveals an aberrant gene expression response

Vasseur, Sophie; Hoffmeister, Albrecht; Garcia-Montero, Andrés; Barthet, Marc; Saint-Michel, Laure; Berthézène, Patrice; Fiedler, Fritz; Closa, Daniel; Dagorn, Jean Charles; Iovanna, Juan Lucio
2003-09-08

Digital.CSIC (Spain)

100

Mice lacking thyroid hormone receptor Beta show enhanced apoptosis and delayed liver commitment for proliferation after partial hepatectomy.

López-Fontal, Raquel; Zeini, Miriam; Través, Paqui G.; Gómez-Ferrería, Mariana; Aranda, Ana; Sáez, Guillermo T.; Cerdá, Concha; Martín-Sanz, Paloma; Hortelano, Sonsoles; Boscá, Lisardo
2010-01-14

Digital.CSIC (Spain)

101

Mice lacking thyroid hormone receptor Beta show enhanced apoptosis and delayed liver commitment for proliferation after partial hepatectomy.

López Fontal, Raquel; Zeini, Miriam; Través, Paqui G.; Gómez Ferrería, Mariana; Aranda, Ana; Sáez, Guillermo T.; Cerdá, Concha; Martín Sanz, Paloma; Hortelano, Sonsoles; Boscá, Lisardo
2010-01-14

Digital.CSIC (Spain)

102

Mercury levels and liver pathology in feral fish living in the vicinity of a mercury cell chlor-alkali factory

Raldúa, Demetrio; Díez Salvador, Sergi; Bayona Termens, Josep María; Barceló, Damià

DRIVER (Spanish)

103

Mercury levels and liver pathology in feral fish living in the vicinity of a mercury cell chlor-alkali factory

Raldúa, Demetrio; Díez Salvador, Sergi; Bayona Termens, Josep María; Barceló, Damià
2007-01-01

Digital.CSIC (Spain)

104

Mecanismos moleculares en el daño por isquemia-reperfusión hepática y en el preacondicionamiento isquémico/ Molecular mechanisms in liver ischemic-reperfusion injury and ischemic preconditioning

Romanque U, Pamela; Uribe M, Mario; Videla, Luis A
2005-04-01

Resumen en inglés Ischemia-reperfusion (IR) liver injury is associated with temporary clamping of hepatoduodenal ligament during liver surgery, hypoperfusion shock and graft failure after liver transplantation. Mechanisms of IR liver injury include: i) loss of calcium homeostasis, ii) reactive oxygen and nitrogen species generation, iii) changes in microcirculation, iv) Kupffer cell activation, and (v) complement activation. Pre-exposure of the liver to transient ischemia increases the tol (mas) erance to IR injury, a phenomenon known as hepatic ischemic preconditioning (IP). IP involves: i) recovery of the energy supply and calcium, sodium and pH homeostasis, ii) enhancement in the antioxidant potential, and iii) expression of multiple stress-response proteins, including acute phase proteins, heat shock proteins, and heme oxygenase. These observations and preliminary studies in humans give a rationale for the assessment of IP in minimizing or preventing IR injury during surgery and non surgical conditions of tissue hypoperfusion

Scientific Electronic Library Online (Spanish)

105

Mecanismos de lesión hepatocelular/ Mechanisms of liver injury

Muntané, J.; González, R.; Ranchal, I.; Collado, J. A.; López-Sánchez, L. M.; Herencia, C.; Rodríguez-Ariza, A.; Muñoz-Castañeda, J. R.; de la Mata, M.
2007-07-01

Scientific Electronic Library Online (Spanish)

106

Marked differences in the splanchnometry of farm-bred and wild red-legged partridges (Alectoris rufa L.)

Millán Gasca, Javier; Gortázar, Christian; Villafuerte, Rafael

4 pages, 1 table.-- PMID: 11469664 [PubMed].-- Article available Open Access at: http://www.ncbi.nlm.nih.gov/pubmed/11469664?dopt=Abstract | Relative weights of heart, spleen, pancreas, and liver and the relative lengths of the small intestine and the cecum were taken from 40 farm-bred and 43 wild j...

DRIVER (Spanish)

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108

Local immune response to experimental ovine dicrocoeliosis

Ferreras, Mª del Carmen; Manga-González, M. Yolanda; Pérez, C.; García-Iglesias, M. J.; Campo, Raquel; González Lanza, Camino; Escudero, A.; García Marín, Juan Francisco
2000-01-01

Digital.CSIC (Spain)

110

Linomide prevents the lethal effect of anti-fas antibody and reduces fas-mediated ceramide production in mouse hepatocytes

Redondo, Clara; Flores, Ignacio; González, Ana; Nagata, Shigekazu; Carrera, Ana C.; Mérida, Isabel; Martínez-Alonso, Carlos

DRIVER (Spanish)

111

Linomide prevents the lethal effect of anti-fas antibody and reduces fas-mediated ceramide production in mouse hepatocytes

Redondo, Clara; Flores, Ignacio; González García, Ana; Nagata, Shigekazu; Carrera, Ana C.; Mérida, Isabel; Martínez-Alonso, Carlos
1996-09-01

Digital.CSIC (Spain)

112

Lesiones hepáticas sugestivas de angioma en pacientes con hepatopatía crónica/ Angioma-like liver lesions in patients with chronic liver disease

Repiso, A.; Gómez Rodríguez, R.; González de Frutos, C.; Artaza, T. de; Sánchez Ruano, J. J.; Pérez Grueso, M. J.; Martínez Potenciano, J. L.
2007-05-01

Resumen en español Objetivo: el objetivo de nuestro estudio fue valorar en nuestro medio las características clínicas, ecográficas y evolutivas de los pacientes con hepatopatía crónica y lesiones ecográficas sugestivas de angiomas hepáticos. Material y métodos: estudio retrospectivo realizado entre los pacientes recogidos en la base de datos de la Unidad de Ecografías del Servicio de Aparato Digestivo entre enero de 2000 y junio de 2004. Incluimos en el estudio a pacientes que pres (mas) entaban datos clínicos y/o analíticos compatibles con hepatopatía crónica de cualquier etiología y en los que la ecografía abdominal ponía de manifiesto la existencia de al menos una lesión hepática compatible con angioma. Se han recogido los datos epidemiológicos, clínicos, ecográficos y evolutivos de estos pacientes. Resultados: durante el periodo de estudio se diagnosticaron 58 pacientes con hepatopatía crónica y lesiones hepáticas sugestivas de angioma, de los cuales trece presentaban datos clínicos, analíticos, ecográficos y/o histológicos compatibles con cirrosis hepática. Ecográficamente se trataban de lesiones menores de 10 mm en el 50% de los pacientes y en la mayoría de los casos localizadas en lóbulo hepático derecho. Durante el periodo de medio de 35 meses (6 a 168 meses) se pudo comprobar cómo en dos pacientes (3%) las lesiones inicialmente interpretadas como angiomas se trataban en realidad de lesiones malignas (un hepatocarcinoma y unas metástasis de adenocarcinoma vesicular). En ambos casos los pacientes eran cirróticos. Por tanto, en el 15% de los pacientes cirróticos de nuestra serie se demostró la naturaleza maligna de las lesiones inicialmente interpretadas como angiomas. Conclusiones: en pacientes con hepatopatía crónica, sobre todo en cirróticos, un porcentaje no despreciable de las lesiones ecográficas interpretadas inicialmente como angiomas se tratan realmente de lesiones malignas. Resumen en inglés Objective: the aim of this study was to evaluate in our healthcare area the clinical, ultrasonographic, and evolutionary features of patients with chronic liver disease and angioma-like liver lesions on ultrasonography. Materials and methods: we conducted a retrospective study amongst patients seen at the Ultrasonography Unit, Gastroenterology Department between January 2000 and June 2004. Included in the study were patients that presented with clinical and/or laboratory (mas) complaints consistent with chronic liver disease of any etiology, and those in which abdominal ultrasounds revealed the existence of at least one angioma-like liver lesion. All relevant epidemiological, clinical, ultrasonographic, and evolutionary data were carefully collected and recorded. Results: in the course of our study, 58 patients were diagnosed with chronic liver disease and angioma-like liver lesions, of which 13 showed clinical, laboratory, ultrasonographic, and/or histological signs of liver cirrhosis. In 50% of patients these lesions were less than 10 mm in diameter, and in most cases were located in the right hepatic lobe. During an average follow-up period of 35 months (6-168 months) we verified that, in two patients, these lesions, initially interpreted as angiomas were in fact malignancies (one hepatocellular carcinoma and one metastatic adenocarcinoma of the gallbladder). In both cases, the patients were cirrhotic. Thus, our study revealed that 15% of lesions found in cirrhotic patients initially interpreted as angiomas were actually malignant. Conclusions: our study revealed that, in patients with chronic liver disease, particularly in cirrhotic patients, a considerable percentage of ultrasonographic lesions originally interpreted as angiomas are in fact malignant tumors.

Scientific Electronic Library Online (Spanish)

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Jejunal microvilli atrophy and reduced nutrient transport in rats with advanced liver cirrhosis: improvement by Insulin-like Growth Factor I

Castilla-Cortázar, Inma; Pascual, María; Urdaneta, Elena; Pardo, Javier; Puche, Juan Enrique; Vivas, Bárbara

This article is available from: http://www.biomedcentral.com/1471-230X/4/12 | [Background] Previous results have shown that in rats with non-ascitic cirrhosis there is an altered transport of sugars and amino acids associated with elongated microvilli. These alterations returned to normal with the a...

DRIVER (Spanish)

115

Isolation and characterization of (gamma, delta) CD4+ T Cell clones derived from human fetal liver cells

Aparicio, Pedro; Alonso, José M.; Toribio, Maria Luisa; Marcos, Miguel A. R.; Pezzi, Luis; Martínez-Alonso, Carlos

DRIVER (Spanish)

116

Interaction of liver methionine adenosyltransferase with hydroxyl radical

Sánchez-Góngora, Estrella; Ruiz, F.; Mingorance, Jesús; An, W.; Corrales, Fernando J.; Mato, José M.
1997-10-01

Digital.CSIC (Spain)

117

Insulin-like growth factor and epidermal growth factor treatment: new approaches to protecting steatotic livers against ischemia-reperfusion injury

Casillas-Ramírez, Araní; Zaouali, Amine; Padrissa-Altés, Susagna; Ben Mosbah, Ismail; Pertosa, Anna; Alfany-Fernández, Izabel; Bintanel-Morcillo, Maria; Xaus, Carme; Rimola, Antoni; Rodés, Juan; Roselló Catafau, Joan; Peralta, Carmen
2009-03-12

Digital.CSIC (Spain)

119

Insuficiencia hepática aguda en amiloidosis hepática asociada a mieloma múltiple: Caso clínico/ Acute liver failure in a patient with liver amyloidosis associated to multiple myeloma

Berríos F, Marcela; Armas-Merino, Rodolfo; Franco S, Carmen; Parrochia B, Esteban; Wolff F, Carlos
2003-11-01

Resumen en inglés We report a 67 years old woman admitted to the hospital for the study of a cholestatic jaundice and massive hepatomegaly. On admission, the patient did not have liver failure. During hospital stay, the patient experienced a progressive deterioration of liver function and a monoclonal gammopathy was detected. An IgG Kappa myeloma was diagnosed. A fine needle liver biopsy disclosed the presence of amyloid. The patient developed acute liver failure and died three weeks after admission (Rev Méd Chile 2003; 131: 1301-04)

Scientific Electronic Library Online (Spanish)

120

Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice

González-Rodríguez, Águeda; Mas Gutiérrez, José Antonio; Sanz-González, Silvia; Ros, Manuel; Burks, Deborah J.; Valverde, Ángela M.
2009-11-22

Digital.CSIC (Spain)

121

Increased sensitivity to oxidative injury in chinese hamster ovary cells stably transfected with rat liver S-adenosylmethionine synthetase cDNA

Sánchez-Góngora, Estrella; Pastorino, John G.; Álvarez, Luis; Pajares, María A.; García, Concepción; Viña, Juan R.; Mato, José M.; Farber, John L.
1996-11-01

Digital.CSIC (Spain)

123

In Vivo Activity of the Thyroid Hormone Receptor {beta}- and α-Selective Agonists GC-24 and CO23 on Rat Liver, Heart, and Brain

Grijota Martínez, María del Carmen; Samarut, Eric; Scanlan, Thomas S.; Morte Molina, Beatriz; Bernal Carrasco, Juan
2011-03-30

Digital.CSIC (Spain)

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125

In Vitro Bioactivation of 3-(N-Phenylamino)propane-1,2-diol by Human and Rat Liver Microsomes and Recombinant P450 Enzymes. Implications for Toxic Oil Syndrome.

Martínez-Cabot, Anna; Morató, Anna; Commandeur, Jan N. M.; Vermeulen, Nico P. E.; Messeguer Peypoch, Àngel
2007-03-08

Digital.CSIC (Spain)

126

Impairment of drug metabolizing system in experimental dicroceliosis

Sánchez Campos, S.; López, P.; Campo, Raquel; Tuñón, M. J.; González, P.; Manga-González, M. Yolanda; González-Gallego, J.
1994-01-01

Digital.CSIC (Spain)

127

Impairment of H+-K+-ATPase-dependent proton transport and inhibition of gastric acid secretion by ethanol

Valle, Juan C. del; Salvatella, María; Rossi, Irma; Andrade, Ramón; Gutiérrez, Yolanda; Pereda, Carmen; Samper, Begoña; Felíu, Juan E.
2001-06-01

Digital.CSIC (Spain)

128

Immunohistochemical study of the local immune response in lambs experimentally infected with Dicrocoelium dendriticum (Digenea)

Ferreras, Mª del Carmen; Campo, Raquel; González Lanza, Camino; Pérez, V.; García-Marín, J. F.; Manga-González, M. Yolanda

9 pages, 9 figures.-- PMID: 17393185 [PubMed].-- Available online 29 March 2007. | Phenotypic expression of inflammatory cells in liver and hepatic lymph nodes (HLN) has been examined in lambs experimentally infected with Dicrocoelium dendriticum using immunohistochemical techniques. Thirty-two lamb...

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130

Histopathological changes induced by lindane (γ-HCH) in various organs of fishes

González de Canales, María Luisa; Ortiz, Juan B.; Sarasquete, M.ª Carmen
2003-03-03

Digital.CSIC (Spain)

131

Histopathological and immunohistochemical study of lambs experimentally infected with Fasciola hepatica and Schistosoma bovis

Ferreras, Mª del Carmen; García-Iglesias, M. J.; Manga-González, M. Yolanda; Pérez-Martínez, C.; Mizinska, Y.; Ramajo Martín, Vicente; González Lanza, Camino; Escudero, A.; García-Marín, J. F.
2000-12-01

Digital.CSIC (Spain)

133

Hiperplasia linfoide nodular hepática: Pseudolinfoma hepático/ Nodular lymphoid hyperplasia of the liver: Hepatic pseudolymphoma

Jiménez, R.; Beguiristain, A.; Ruiz-Montesinos, I.; Villar, F.; Medrano, M. A.; Garnateo, F.; Vaquero, J.; Echenique Elizondo, M.
2007-05-01

Scientific Electronic Library Online (Spanish)

134

Hidatidosis hepática: manejo actual de una entidad aún presente/ Liver hidatidosis: a current management of a present disease

Adán Merino, L.; Alonso Gamarra, E.; Gómez Senent, S.; Froilán Torres, C.; Martín Arranz, E.; Segura Cabral, J. M.
2008-08-01

Scientific Electronic Library Online (Spanish)

135

Hidatidosis hepática/ Liver hydatidosis

Gentile, Fernando; Litvak, Edith; Gay, Cynthia; Mateos, Fernanda; Salgueiro, Fabián; Moscatelli, Guillermo
2010-12-01

Scientific Electronic Library Online (Spanish)

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Hereditary hepatic and systemic amyloidosis caused by a new deletion/insertion mutation in the apolipoprotein Al gene

Booth, DR; Tan, SY; Booth, SE; Tennent, GA; Hutchinson, WL; Hsuan, JJ; Totty, NF; Truong, O; Soutar, AK; Hawkins, PN; Bruguera, M

We report a Spanish family with autosomal-dominant non-neuropathic hereditary amyloidosis with a unique hepatic presentation and death from liver failure, usually by the sixth decade. The disease is caused by a previously unreported deletion/insertion mutation in exon 4 of the apolipoprotein AI (apo...

DRIVER (Spanish)

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Hereditary hepatic and systemic amyloidosis caused by a new deletion/insertion mutation in the apolipoprotein AI gene.

Soutar, A K; Caballería, J; Booth, S E; Bruguera, M; Solé, M; Hutchinson, W L; Hsuan, J J; Tennent, G A; Booth, D R; Tan, S Y

We report a Spanish family with autosomal-dominant non-neuropathic hereditary amyloidosis with a unique hepatic presentation and death from liver failure, usually by the sixth decade. The disease is caused by a previously unreported deletion/insertion mutation in exon 4 of the apolipoprotein AI (apo...

DRIVER (Spanish)

138

Hereditary hepatic and systemic amyloidosis caused by a new deletion/insertion mutation in the apolipoprotein AI gene.

Booth, David R.; Tan, Si-Yen; Booth, Sussanne E.; Tennent, Glenys A.; Hutchinson, Winston L.; Hsuan, J. Justin

We report a Spanish family with autosomal-dominant non-neuropathic hereditary amyloidosis with a unique hepatic presentation and death from liver failure, usually by the sixth decade. The disease is caused by a previously unreported deletion/insertion mutation in exon 4 of the apolipoprotein AI (apo...

DRIVER (Spanish)

139

Hepatotoxicidad secundaria a "productos naturales": análisis de los casos notificados al Registro Español de Hepatotoxicidad/ Liver injuries induced by "natural remedies": an analysis of cases submitted to the Spanish Liver Toxicity Registry

García-Cortés, M.; Borraz, Y.; Lucena, M. I.; Peláez, G.; Salmerón, J.; Diago, M.; Martínez-Sierra, M. C.; Navarro, J. M.; Planas, R.; Soria, M. J.; Bruguera, M.; Andrade, R. J.
2008-11-01

Resumen en español Introducción: la toxicidad hepática asociada al uso creciente de productos de "remedios naturales" es un fenómeno emergente. Objetivos: valoración de las características epidemiológicas, clínicas y demográficas de los casos de hepatotoxicidad secundarios a productos herbales (PH) y suplementos dietéticos (SD). Pacientes y métodos: análisis de los casos de hepatotoxicidad debida a PH y SD incluidos en el Registro Español de Hepatotoxicidad. Resultados: trece ca (mas) sos de un total de 521 casos (2%) de reacciones adversas hepáticas incluidas en el registro entre 1994 y 2006, eran secundarios a PH/SD, representando el décimo grupo terapéutico responsable por orden de frecuencia, por delante de analgésicos, ansiolíticos y antipsicóticos. Nueve pacientes (69%) eran mujeres y la edad media fue de 45 años. Nueve pacientes (69%) presentaron ictericia. El tipo de daño más frecuente fue el hepatocelular (12; 92%) y un 31% de los casos presentaron datos de hipersensibilidad. La sustancia más comúnmente involucrada en los casos de daño hepático fue la Camellia sinensis (23%) seguida de Rhamnus purshianus e isoflavonas (Fitosoja®, Biosoja®) con dos casos cada uno (15%). Tres casos (23%) presentaron re-exposición positiva. Conclusiones: la hepatotoxicidad originada por PH/SD no es excepcional, y su perfil es la hepatitis aguda hepatocelular ictérica predominantemente en mujeres. La frecuente ocurrencia de reexposición positiva en estos pacientes indica un bajo índice de sospecha y un retraso o ausencia de diagnóstico de este tipo de reacción adversa. Resumen en inglés Background: toxic liver damage associated with the use of natural remedies is a growing health problem. Objectives: to analyze the demographics, and clinical and epidemiological characteristics of patients developing liver injury related to these remedies. Patients and methods: all DILI cases associated with the use of herbal remedies (HR) or dietary supplements (DS) submitted to the Spanish Registry were analyzed. Type of liver damage, severity, and outcome were specific (mas) ally evaluated. Results: thirteen cases out of 521 DILI cases (2%) submitted to the Spanish Liver Toxicity Registry between 1994 and 2006 were related to HR/DS, which ranked as the 10th therapeutic group with a greater number of cases and above pain killers, anxiolytics, and antipsychotic drugs. Nine patients (69%) were female (mean age 45 years). Nine cases (69%) had jaundice at presentation. The predominating type of liver damage was hepatocellular (12; 92%), and 31% of cases exhibited the common features of hypersensitivity. Camellia sinensis (3, 23%) was the main causative herb, followed by Rhamnus purshianus and isoflavones (Fitosoja®, Biosoja®) (2 cases each, 15%). Three cases (23%) were rechallenged with the offending product. Conclusions: the incidence of hepatic damage related to HR/DS is not so rare, the most common profile of affected patients being a woman with acute hepatocellular hepatitis. Low suspicion regarding the putative role of herbs in hepatotoxicity makes diagnosis more difficult, and probably increases the incidence of inadvertent rechallenge in these patients.

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Hepatopatía crónica asociada a fibrosis quística: gasto energético en reposo, factores de riesgo y repercusión en la evolución de la enfermedad/ Chronic liver disease associated with cystic fibrosis: energy expended at rest, risk factors and impact on the disease's progress

Tabernero da Veiga, S.; González Lama, Y.; Lama More, R.; Martínez Carrasco, M. C.; Antelo Landeria, M. C.; Jara Vega, P.
2004-02-01

Resumen en español Introducción y objetivos: La fibrosis quística es la enfermedad recesiva más frecuente. Existen diferentes alteraciones hepatobiliares; la más importante es el desarrollo de obstrucción biliar y fibrosis periportal. El objetivo es valorar la influencia de la hepatopatía en el estado nutricional, la evolución de la enfermedad y los factores de riesgo asociados. Ámbito: Unidad de Nutrición del Servicio de Gastroenterología del Hospital Infantil La Paz. Material y (mas) métodos: Estudio longitudinal prospectivo con 53 pacientes valorados en tres momentos durante 3 años; al inicio, al año y a los 3 años. Solo 37 se siguieron los 3 años. Se realizan 111 mediciones que incluyen: análisis de la composición corporal, del gasto energético, de la ingesta y de las pérdidas energéticas así como balance nitrogenado. Simultáneamente se realizan pruebas de función respiratoria y se valora la presencia de reagudización respiratoria. Resultados: 37 pacientes, 19 mujeres y 18 varones (edad media 13,04 años ± 3,28). Doce (32,43%) fueron diagnosticados de hepatopatía (edad media 12,16 años ± 3,86 DS, 11 varones, 1 mujer) de los cuales 1 presentó íleo meconial, 5 eran homocigotos, 5 heterocigotos y los 2 restantes presentaban otras mutaciones. Los hepatópatas presentan parámetros antropométricos mejores o similares que los pacientes sin hepatopatía (p NS). Media del índice de Waterlow en hepatópatas: 93,62% ± 7,87 DS; no hepatópatas: 93,06% ± 10,97 DS (p NS). Media de FEV1 en hepatópatas: 88,81 ± 27,32 DS; no hepatópatas: 75,21 ± 27,92 DS (p Resumen en inglés Introduction and goals: Cystic fibrosis is the most frequent recessive disease. There are various hepato-biliary alterations, of which the most important is the development of biliary obstruction and periportal fibrosis. The goal is to assess the influence of liver disease on the nutritional status, the progress of the disease and the associated risk factors. Scope: Nutrition Unit of the Gastroenterology Department at La Paz Children’s Hospital. Material and methods: Pro (mas) spective longitudinal study with 53 patients assessed on three occasions over 3 years: at inclusion, after 1 year and after 3 years. Only 37 of them were followed-up for 3 years. A total of 111 measurements were taken, including analysis of body composition, energy expenditure, intake and energy losses as well as nitrogen balance. Simultaneously, respiratory function tests were performed and the presence of repeated acute respiratory problems was evaluated. Results: 37 patients, 19 females and 18 males (mean age 13.04 years ± 3.28). Twelve (32.43%) were diagnosed as having liver disease (mean age 12.16% ± 3.86 SD, 11 males, 1 female), of whom 1 presented meconial ileum, 5 were homozygotic, 5 heterozygotic and the other two presented other mutations. Those with liver disease presented anthropometric parameters that were better than or similar to the patients without liver involvement (p NS). Mean Waterlow index in liver disease sufferers: 93.62% ± 7.87 SD; without liver disease: 93.06% ± 10.97 SD (p NS). Mean of LVEF in liver disease sufferers: 88.81 ± 27.32 SD; without liver disease: 75.21 ± 27.92 SD (p

Scientific Electronic Library Online (Spanish)

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Hepatocarcinoma con componente sarcomatoide: Caso clínico/ Hepatocarcinoma with sarcomatoid transformation: Case report

Losada M, Héctor; Roa, Juan Carlos; García M, Darío; Araya, Juan Carlos; Burgos SJ, Luis; Silva A, Jorge
2007-06-01

Resumen en inglés Hepatocarcinoma with sarcomatoid transformation is uncommon. It presents clinically with ¡eucocytosis and fever, resembling a liver abscess. We report a 40 year-old male that presented pain in the right upper quadrant and fever. Abdominal imaging showed an hypodense image in the liver that resembled a liver abscess. The patient was subjected to a percutaneous drainage obtaining 150 ml of an hemorrhagic fluid whose culture was negative. The clinical picture persisted and (mas) the patient was subjected to a right hepatectomy. The pathological study of the surgical piece disclosed a hepatocarcinoma with sarcomatoid transformation. The patient was discharged sixteen days after surgery

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Hepatitis crónica y cirrosis por virus C pre y post trasplante hepático en una niña de 9 años: Report of one case/ Chronic hepatitis and cirrhosis caused by C virus before and after liver transplantation

Alegría Q, Sylvia; Buckel G, Erwin; Ferrario B, Mario; Ceresa O, Sergio; Smok S, Gladys; Brahm B, Javier
2004-04-01

Resumen en inglés We report a girl with a chronic hepatitis caused by C virus diagnosed at the age of nine, unsuccessfully treated with interferon and ribavirine. Two years later, she was subjected to a liver transplantation. She maintained elevated viral loads with a normal pathological study of the liver until 22 months after transplantation. She was treated again with combined antiviral therapy, for 6 months, without response and experienced a progressive deterioration liver function, dying three years after transplantation (Rev Méd Chile 2004; 132: 479-84)

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Hepatic microcirculatory failure | Falência microcirculatória hepática

Ramalho, Fernando Silva; Fernandez-Monteiro, Izabel; Roselló Catafau, Joan; Peralta, Carmen

Liver ischemia has been considered a frequent problem in medical practice, and can be associated to a number of surgical and clinical situations, such as massive hepatic resections, sepsis, liver trauma, circulatory shock and liver transplantation. After restoring blood flow, the liver is further su...

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Hepatic microcirculatory failure

Ramalho, Fernando Silva; Fernandez-Monteiro, Izabel; Roselló Catafau, Joan; Peralta, Carmen
2006-01-01

Digital.CSIC (Spain)

145

Hepatic marker enzymes, biochemical parameters and pathological effects in lambs experimentally infected with Dicrocoelium dendriticum (Digenea)

Manga-González, M. Yolanda; Ferreras, Mª del Carmen; Campo, Raquel; González Lanza, Camino; Pérez, V.

12 pages, 5 figures.-- PMID: 15197580 [PubMed].-- Available online 10 Jun 2004. | Hepatic enzymes and biochemical parameter values were analysed in the sera of 32 lambs: 12 infected with 1,000 Dicrocoelium dendriticum metacercariae, 12 with 3,000 and eight controls. Blood samples were collected at i...

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Hepatic marker enzymes, biochemical parameters and pathological effects in lambs experimentally infected with Dicrocoelium dendriticum (Digenea)

Manga-González, M. Yolanda; Ferreras, Mª del Carmen; Campo, Raquel; González Lanza, Camino; Pérez, V.; García-Marín, J. F.
2004-01-01

Digital.CSIC (Spain)

147

Hepatectomía laparoscópica de lesión hiperplásica hepática/ Laparoscopic hepatectomy of a focal nodular hyperplasia of the liver

Prieto Nieto, M. I.; Pérez Robledo, J. P.; Erdozain, J. C.; Caminoa Lizarralde, A.; Torre, C. de la; Carrión, G.; Pascual, I.; Burgos Lizaldez, E.; Larrauri Martínez, J.; Rodríguez-Montes, J. A.; García-Sancho Martín, L.
2007-12-01

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Hematoma subcapsular hepático tras CPRE/ Subcapsular liver hematoma after ERCP

Priego, P.; Rodríguez, G.; Mena, A.; Losa, N.; Aguilera, A.; Ramiro, C.; Lisa, E.; Conde, S.; Fresneda, V.
2007-01-01

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Hamartoma mesenquimatoso hepático en un anciano/ Mesenchymal hamartoma of the liver in an elderly man

Giunippero, Alejandro; Maya, Antonio M.; Gallo, Antonio; Bazzana, María S.; Cosentino, Valeria; Aulet, Francisco J.
2009-10-01

Resumen en español El hamartoma mesenquimatoso hepático es un tumor benigno poco frecuente, formado por alteraciones de la placa hiliar y compuesto por tejidos mixomatoso, mesenquimático y conductos biliares anormales en proporciones variables. Habitualmente son formaciones hepáticas múltiples, quísticas y sin comunicación con la vía biliar. Es más frecuente en niños, es raro en adultos. El primer caso fue publicado por Yamamura et al en 1976, y se encuentran pocos en la bibliografía. Presentamos el caso de un paciente de 87 años con un hamartoma hepático quístico de 20 cm. Resumen en inglés The mesenchymal hamartoma of the liver is a non frequent benign tumor with a ductal plate malformation, consisting of myxoid mesenchymal tissue and abnormal bile ducts in different proportion. Usually it presents as multiple liver cyst formations without communication with the principal bile duct. They are frequent in children, being rare in adults. The first case was reported by Yamamura et al in 1976, and very few cases are reported in the bibliography. We present the case of an elder 87 year old male who presented a 20 cm mesenchymal hamartoma liver cyst.

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Glucocorticoid-induced DNA demethylation and gene memory during development

Thomassin, Hélène; Flavin, Michèle; Espinás, María Luisa; Grange, Thierry
2001-04-17

Digital.CSIC (Spain)

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Glucocorticoid regulation of hepatic S-adenosylmethionine synthetase gene expression

Gil, Beatriz; Pajares, María A.; Mato, José M.; Álvarez, Luis
1997-03-01

Digital.CSIC (Spain)

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Gastritis varioliforme y daño hepático crónico: Una inesperada asociación/ Association between varioliform gastritis and cirrhosis

ROBLERO, JUAN PABLO; ITURRIAGA, HERNÁN; ESTELA, RICARDO
2010-08-01

Resumen en inglés Background: Varioliform gastritis (VG) is found in approximately 0.3 to 2.8% of upper gastrointestinal endoscopies. Its etiology is not known. We have observed a higher frequency of VG in patients with liver cirrhosis. Aim: To confirm if there is an association between VG and liver cirrhosis. Patients and Methods: Two case-control studies were done. A retrospective study, reviewing the endoscopy database of a gastroenterological unit. A prospective study, identifying case (mas) s with the endoscopic diagnosis of VG among all patients referred for upper gastrointestinal endoscopies. The presence of liver cirrhosis, based on clinical, laboratory, ultrasonographic and endoscopic features was registered among patients with VG. Results: VG was found in 549 of 11.659 upper gastrointestinal endoscopies. Fourteen percent of patients with VG had cirrhosis compared to 5.6% in control patients (c² 29,8; p

Scientific Electronic Library Online (Spanish)

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Fracaso hepático agudo tras golpe de calor/ Acute liver failure following heat stroke

Pardo Cabello, A. J.; Benticuaga Martínez, M. N.; Martín Moreno, A.; Miras Parra, F. J.; Sabio Reyes, F.
2005-09-01

Resumen en español La afectación hepática en el curso de un golpe de calor suele ser un proceso frecuente, necesitando en algunos casos muy graves y raros de la realización de trasplante hepático. Presentamos el caso de un paciente varón de 31 años, deportista amateur, que mientras participaba en una competición de maratón sufrió un golpe de calor con fracaso hepático agudo acompañado de rabdomiolisis, insuficiencia renal y coagulopatía. La elevada temperatura ambiental, la dura (mas) ción del ejercicio y la altura a la que se realizó pudieron contribuir a la aparición del cuadro. La evolución del paciente, tras la aplicación de medidas conservadoras, fue favorable recibiendo el alta hospitalaria en pocos días. Resumen en inglés Hepatic involvement during heat stroke appears frequently. In some severe and rare cases liver transplantation is needed. We report a case of a 31 years old man, amateur runner, who suffered heat stroke-related acute liver failure, rhabdomyolysis, renal failure and coagulation im-pairment during a marathon. High environmental temperature, exercise duration and height where race took place could be involved. Patient had a favourable course with conservative treatment being discharged in a few days.

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First evidence of polybrominated diphenyl ether (flame retardants) effects in feral barbel from the Ebro River basin (NE, Spain)

Raldúa, Demetrio; Padrós, Francesc; Solé, Montserrat; Eljarrat, Ethel; Barceló, Damià; Riva, M. Carmen; Barata Martí, Carlos
2008-08-01

Digital.CSIC (Spain)

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Fenómeno de acomodación inmunológica: Trasplante hepático ABO incompatible. Caso clínico/ Accomodation process: ABO-incompatible liver transplantation. Report of one case

Castro, Lorena; Yarur, Andrés; Segovia, Roberto; Ponce, Rodrigo; Uribe, Mario; Ferrario, Mario; Buckel, Erwin; Iturriaga, Hernán
2009-08-01

Resumen en inglés We report a 33 year-old female with a diagnosis of halothane-induce fulminant hepatic failure who was subjected to a liver transplant with an ABO-incompatible graft. The patient received a therapeutic protocol that included total plasma exchange, splenectomy and quadruple immunosuppression. After 5 years, the patient remains asymptomatic and with normal liver enzymes, while she has been treated with low dose of immunosuppressive drugs. This case demonstrates an example of (mas) how the immunological process of accomodation opens the possibility of using ABO-incompatible organs as a definitive grafts

Scientific Electronic Library Online (Spanish)

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Fallo hepático fulminante asociado al uso de cocaína/ Cocaine-related fulminant liver failure

Campos Franco, J.; Martínez Rey, C.; Pérez Becerra, E.; González Quintela, A.
2002-07-01

Resumen en español Una paciente de 23 años presentó datos bioquímicos de hepatitis aguda grave asociados a confusión y asterixis pocas horas después de esnifar una dosis elevada de cocaína. Los niveles sanguíneos de cocaína se encontraban muy elevados y en la biopsia hepática realizada pocos dias más tarde se observó necrosis centrolobulillar. La recuperación fue completa con tratamiento conservador. La toxicidad de la cocaína se debe tener en cuenta en casos similares de insuficiencia hepática aguda grave. Resumen en inglés A 23-year-old woman developed biochemical signs of acute severe hepatitis together with confusion and flapping tremor after snorting a large dose of cocaine. Blood levels of cocaine were very high and liver biopsy performed few days later showed centrilobular necrosis. She recovered completely with conservative measures. Cocaine toxicity should be considered in similar cases of fulminant liver failure.

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Evolución del injerto renal en los pacientes con trasplante hepático asociado/ Renal graft outcome in patients with associated liver transplant

Gutiérrez Baños, J.L.; Portillo Martín, J.A.; Ballestero Diego, R.; Zubillaga Guerrero, S.; Ramos Barselo, E.; Campos Sañudo, J.A.
2008-02-01

Resumen en español Introducción: Casi el 50% de los receptores de trasplante hepático (TxH) tienen asociada un insuficiencia renal (IR) en diverso grado, a su vez, los pacientes en hemodiálisis tienen mayor riesgo de desarrollar procesos hepáticos en relación con infecciones víricas o patologías concomitantes. La mejora en las técnicas de conservación de órganos, quirúrgicas y en el tratamiento inmunosupresor ha permitido que los pacientes necesitados de un segundo órgano sean i (mas) ncluidos en lista de espera para trasplante bien sincrónico o asincrónico. Objetivos: Revisión de los resultados obtenidos en el trasplante renal (TxR) en pacientes que tienen asociado un TxH de forma sincrónica o asincrónica. Material y métodos: Estudio retrospectivo de los pacientes con TxH y TxR realizados en nuestro Hospital. Se revisaron las características de los pacientes, causa de fallo hepático y renal, evolución del paciente y del injerto renal y las complicaciones en relación con el injerto renal. Resultados: Desde 1975 hemos realizado 1483 TxR y 409 TxH desde 1991, se hicieron 17 TxR en 15 de estos pacientes (3,7%). 4 pacientes eran mujeres (26,7%) y 11 varones (73,3%). La edad al TxH fue 52,5±9,3 años (entre 37 y 61 años) siendo las causas de fracaso hepático cirrosis enólica en 10 pacientes, hepatoma en 3 y hepatopatía vírica en 2. El TxR se hizo a una edad de 51±12.5 años (35 y 66 años). La causa de fallo renal fue glomerulonefritis crónica en 6 casos, nefropatía diabética en 3, nefropatía hipertensiva en 1, poliquistosis renal en 1 y no filiada en 4. La isquemia fría fue de 20,5±5,4horas (8-27 horas) en los asincrónicos y 6,4±5,4 en los sincrónicos (6-8 horas). Tres pacientes tenían TxR previo al hepático, 2 funcionantes sin que el TxH les afectase, y otro le había perdido por recidiva de glomerulonefritis IgA recibiendo un TxH y TxR sincrónico. La causa del fallo hepático en los 3 casos fueron hepatomas en relación con hepatopatías víricas B y C. En 6 casos se hizo Tx simultáneo y en 8 el Tx renal se hizo entre 16 y 83 meses tras el TxH (x=50,5±25,9 meses). Hubo diuresis inmediata en 3 de los sincrónicos (50%) y 3 de los asincrónicos (17,7%). Se perdió un injerto renal por trombosis venosa a las 24 horas y otros 2 por recidiva de la enfermedad (1 caso previo al TxH). El resto eran injertos funcionantes entre 4 y 264 meses de seguimiento (x=92,5±66,7 meses) con una creatinina media de 1,86±9,48 mg/100 oscilando entre 1 y 4,5. Han fallecido 5 pacientes, 4 por fracaso del injerto hepático con riñón funcionante a los 8 y 11 meses y 7 y 21 años con cifras de creatinina respectivamente de 3, 4,5, 1,1 y 1,1; otro paciente falleció a los 14 años por cáncer de esófago con creatinina de 1,16. Complicaciones en los casos asincrónicos fueron 5 rechazos agudos, 3 necrosis tubulares, 1 infección de herida, 1 hematoma perirrenal, 2 estenosis ureterales, 1 embolismo arterial en pierna derecha. En los casos sincrónicos no hubo casos de rechazo agudo, 2 necrosis tubulares, 1 trombosis venosa, 2 infecciones de herida, 1 hematoma perirenal y 1 fístula urinaria. La inmunosupresión fue variable siendo las asociaciones más frecuentes esteroides más tacrolimus en 7 (en tres casos tenían además micofenolato) y esteroides más ciclosporina en 3 (en 1 caso más micofenolato). Conclusiones: El trasplante hepatorenal es una alternativa válida en los pacientes con insuficiencia hepática y renal terminal. La incidencia de rechazo agudo es parece menor en los casos sincrónicos. Resumen en inglés Introduction: Nearly 50% of liver transplant recipients have some degree of renal failure; patients in haemodialysis treatment have a higher risk of suffering hepatic diseases related to viral infections or concomitant pathologies. Improvement in surgical and organ preservation techniques and immunosuppressive therapy has permitted multiorganic transplants in patients needing both liver and kidney organs. Objectives: To review our results in renal transplants in those pat (mas) ients with liver and kidney transplants. Material and method: Retrospective study of the 15 patients with liver and kidney transplants performed in our Hospital. We have reviewed patients´ main characteristics, liver and renal failure causes, renal graft and patient outcome and complications relate to renal transplant. Results: Between 1975 and December 2006 we performed 1483 kidney transplants and between 1991 and December 2006, 409 liver transplants. We performed multiorganic liver and kidney transplants to 15 patients (4 women and 11 men). The average for liver transplant recipients was 2.5±9.3 years (range 37-61) and for kidney transplant recipients was 51±12.5 years (35-66). Cold ischemia was 6.4±5.4 hours (6-8) in imultaneous liver-kidney transplant and 20.5±5.4 (8-27 hours) in non-simultaneous ones. Three patients had a renal transplant before the liver one (two functioning which had no changes after hepatic transplant but the other was lost due to IgA glomeruloneprhitis relapse and received a imultaneous kidney-liver transplant). Six patients received a simultaneous kidney-liver transplant and eight patients a renal transplant between 16 and 83 months (x=50.5±25.9 months) after the liver transplant. A renal graft was lost due to renal vein thrombosis and two due to IgA relapse; the hers were functioning between 6 and 264 months of follow-up (x=92.5±66.7) with creatinine levels of 1.86±mg/100, (range 1-4.5). Four patients died due to hepatic failure between 8 months and 21 years after renal transplant and another died of oesophagus cancer 14 years after the kidney transplant, in all cases with functioning renal graft. There were no cases of kidney graft acute rejection in simultaneous transplants but there were five in non-simultaneous ones. Immunotherapy was based on steroids and tacrolimus. Conclusions: Liver-kidney transplants are worthy options in patients with hepatic and renal end failure. Acute rejection seems to have fewer incidences in simultaneous liver-kidney transplantation.

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Evaluación de la fibrosis hepática en la hepatitis crónica por virus C mediante la aplicación prospectiva del Sabadell's NIHCED score: Sabadell's Non Invasive, Hepatitis C Related-Cirrhosis Early Detection Score/ Prospective evaluation of liver fibrosis in chronic viral hepatitis C infection using the Sabadell NIHCED: non-invasive hepatitis C related cirrhosis early detection) index

Bejarano, G.; Vergara, M.; Gil, M.; Dalmau, B.; Puig, J.; Bella, M. R.; Suárez, D.; Calvet, X.
2009-05-01

Resumen en español Introducción: la hepatitis crónica por VHC cursa de forma asintomática desarrollando cirrosis hepática y sus complicaciones en un 20-40% de los casos. En estudios previos se ha demostrado que la fibrosis avanzada es un factor pronóstico fundamental. El método gold standard para la valoración del grado de fibrosis es la biopsia hepática. Nuestro grupo ha validado un índice predictivo, el NIHCED (Sabadell's Non Invasive, Hepatitis C related-Cirrosis Early Detection (mas) Score), basado en datos demográficos, analíticos y ecográficos para determinar la presencia de cirrosis. Objetivo: nuestro objetivo es el de evaluar si el NIHCED predice la presencia de fibrosis avanzada en los pacientes con hepatitis crónica por virus C. Material y métodos: estudio prospectivo donde se incluyeron pacientes con hepatitis crónica por VHC. Se les realizó una biopsia hepática y el NIHCED. El grado de fibrosis se correlacionó con el valor del NIHCED mediante curva de ROC y el coeficiente de correlación de Spearman. Resultados: se incluyeron un total de 321 pacientes (ratio hombre/mujer 1,27) con una edad media de 48 ± 14 años. La biopsia hepática mostró que 131 (30,5%) no tenían fibrosis o era expansión portal, mientras que 190 (69,5%) tenían fibrosis avanzada o cirrosis. Para un punto de corte de 6 puntos, la sensibilidad fue del 72%, especificidad del 76,3%, VPP del 81%, VPN del 63,7% y una precisión diagnóstica del 72,5%, con un área bajo la curva fue de 0,787 y un coeficiente de correlación de Spearman de r = 0,65. Conclusiones: el NIHCED predice la presencia de fibrosis avanzada en un elevado porcentaje de pacientes sin necesidad de realizar biopsia hepática. Resumen en inglés Introduction: liver disease resulting from chronic hepatitis C virus (HCV) infection follows an asymptomatic course towards cirrhosis and its complications in 20-40% of cases. Earlier studies demonstrated that advanced fibrosis is a prognostic factor. The "gold standard" for the evaluation of fibrosis grade is liver biopsy. Our group validated a predictive index - NIHCED - based on demographic, laboratory parameters, and echoghraphic data to determine the presence of cirr (mas) hosis. Objective: our objective is to evaluate whether the NIHCED score predicts the presence of advanced fibrosis in patients with chronic HCV infection. Material and methods: this prospective study included patients with chronic HCV infection who underwent liver biopsy and were administered the NIHCED score. Fibrosis grade correlated with the NIHCED score using the ROC curve analysis and Spearman's correlation coefficient. Results: in total 321 patients were included (male/female ratio 1.27) with a mean age of 48 ± 14 years. Liver biopsy showed that 131 (30.5%) had no fibrosis or had portal expansion while 190 (69.5%) had advanced fibrosis or cirrhosis. At a cut-off point of 6, sensitivity was 72%, specificity was 76.3%, positive predictive value (PPV) was 81%, negative predictive value (NPV) was 63.7%, and diagnostic accuracy was 72.5%, with an area under the curve (AUC) of 0.787, and a Spearman's correlation coefficient of r = 0.65. Conclusions: the NIHCED score predicts the presence of advanced fibrosis in an elevated percentage of patients with a need of liver biopsy.

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Estudio prospectivo sobre la utilidad de la ecografía de control tras la realización de pruebas invasivas hepáticas: biopsia hepática y punción aspiración con aguja fina (PAAF)/ A prospective study about the usefulness of ultrasonographic monitoring after invasive liver procedures: liver biopsy and fine-needle aspiration (FNA)

Carrera Alonso, E.; García González, M.; Valer López-Fando, P.; Plaza Palacios, G.; López San Román, A.; Gil Grande, L.; Milicua Salamero, J. M.
2007-03-01

Resumen en español Objetivo: establecer si es necesario realizar una ecografía de control a todos los pacientes sometidos a una biopsia hepática o una punción aspiración con aguja fina, para detectar posibles complicaciones con o sin repercusión clínica. Material y métodos: tras la realización de una biopsia hepática o una punción aspiración con aguja fina según el protocolo habitual, se mantiene al paciente en observación durante 24 horas, realizándose en ese momento una ecog (mas) rafía a todos los pacientes aunque no presenten datos clínicos de complicación. Resultados: se llevaron a cabo 298 biopsias hepáticas y 98 punciones mediante aguja fina. Presentaron complicaciones un total de 37 pacientes (9,34%), de las cuales 36 (9,09%) fueron complicaciones menores en forma de dolor, síncope vasovagal o hemorragia leve y 1 (0,25%) complicación mayor en forma de hemorragia grave. De las 396 exploraciones tan sólo uno de los casos presentó una complicación detectada en la ecografía (hematoma intraparenquimatoso) encontrándose asintomático. Conclusiones: la baja incidencia de complicaciones, que cursan de forma asintomática, y la buena evolución de las mismas hacen poco rentable la realización de ecografía de control tras la realización de dichas técnicas diagnósticas, siendo necesaria tan sólo en el caso de sospecha clínica de complicación. Resumen en inglés Objective: to determine the need to perform ultrasound scans to all patients after liver biopsy or fine-needle aspiration (FNA) in order to detect complications with or without symptoms. Material and methods: after liver biopsy or FNA using a regular protocol the patient is observed for 24 hours at the hospital, and all patients undergo an abdominal sonography at that time even in the absence of evident complications. Results: 298 liver biopsies and 98 FNAs were performed (mas) . There were complications in 37 patients (9.34%): 36 (9.09%) were minor complications such as pain, vasovagal episodes, or small bleeding, and 1 (0.25%) was a major complication with severe hemorrhage. Only 1 out of all 396 procedures had a complication detected by ultrasounds (intrahepatic hematoma) while the patient was asymptomatic. Conclusions: the low incidence of complications occurring without symptoms, and their favorable course suggest that routine ultrasonography is not necessary after these techniques, and that it should be only performed when a complication is suspected.

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Esquistosomiasis con afectación rectal y hepática/ Rectal and liver involvement in schistosomiasis

Baños Madrid, R.; Alemán Lorca, F.; Serrano Jiménez, A.; Alajarín Cervera, M.; Alberca de las Parras, F.; Molina Martínez, J.; Carballo Alvárez, F.
2008-01-01

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Enfoque clínico y diagnóstico del absceso hepático/ A diagnostic approach to hepatic abscess

Pinilla R, Análida Elizabeth; López P, Myriam Consuelo; Castillo M, Blanca; Murcia A, Martha Isabel; Nicholls O, Rubén Santiago; Duque B, Sofía; Orozco V, Luis Carlos
2003-12-01

Resumen en inglés Background: The non invasive diagnosis of amebic liver abscess allows the use of empirical therapy without the requirement of invasive diagnostic procedures. Aim: To determine the discriminatory capacity of clinical, laboratory and ultrasound studies for the etiological diagnosis of liver abscess. Patients and methods: Sixty one patients were initially included in this prospective study, but 12 did not comply with the inclusion criteria. Of the rest, 29 (59%) had an amebi (mas) c liver abscess, 16 (33%) had a pyogenic liver abscess and four (8%) had an abscess of mixed etiology. Blood cultures were done in 42 patients. Ultrasound guided needle aspiration was done in 7 patients with amebic liver abscess and 13 patients with non amebic liver abscess. Results: The clinical picture and ultrasound fndings were similar in all types of amebic abscess. ELISA test for IgG anti-Entamoeba histolytica antibodies were positive in 100% of patients with amebic liver abscess. Antibodies measured by gel diffusion were positive in 93%. All patients with mixed liver abscess had positive antibodies and some of them positive culture. Blood cultures were positive for anaerobic bacteria in five patients. Cultures of aspirated material were positive in 7 patients (obligate anaerobic bacteria in 3 and facultative anaerobic bacteria in the rest). The most common complications, whatever the etiology, were right pleural effusion and systemic inflammatory response. Conclusions: A final model of binomial regression analysis revealed that age under 40 years, an hematocrit greater than 35% and an elevation in prothrombin time of less than 1.5 seconds had enough discriminatory capacity for the diagnosis of amoebic liver abscess (Rev Méd Chile 2003; 131: 1411-20)

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Endocarditis infecciosa en pacientes con daño hepático crónico: Serie de 4 casos clínicos/ Infective endocarditis in patients with chronic hepatic failure: A four cases series

Oksenberg R, Dan; Castelli T, Anna; Fica C, Alberto
2009-06-01

Resumen en español La asociación entre daño hepático y endocarditis infecciosa es infrecuente. Para analizar los factores predisponentes de esta asociación, la etiología microbiana y evolución clínica, se efectuó un análisis retrospectivo de los egresos por endocarditis infecciosa en pacientes con cirrosis hepática desde 1995 a junio de 2008. Se identificaron cuatro casos, asociados a categoría Child A en tres y en todos había una cardiopatía predisponente. Las manifestaciones (mas) clínicas fueron clásicas excepto en un caso que se presentó como descompensación hepática. Sólo un caso se asoció a un agente típico, otros a un agente nosocomial y Corynebacterium diphtheriae. En un caso no se identificó la etiología. Uno de los pacientes requirió cirugía de reemplazo valvular. Tres pacientes se recuperaron (Child A) y el paciente en categoría Child C falleció. Aunque infrecuente, la asociación cirrosis y endocarditis ocurre en la práctica clínica, se puede asociar a agentes inhabituales y tener manifestaciones encubiertas Resumen en inglés Infective endocarditis and liver cirrhosis is an infrequent association. A retrospective study was performed in order to characterize predisposing factors, microbial causes and evolution. Medical records between 1995 and 2008 (June) were searched. Four cases were identified. In three cases liver cirrhosis was in stage Child A, and in all 4 there was a predisposing cardiac disease. Clinical manifestations were classical in 3 cases and in one presented as hepatic failure. O (mas) nly in one case a typical agent was recovered. Other cases were associated to a nosocomial agent or Corynebacterium diphtheriae, and in one no agent was identified. One patient required valve replacement. Three patients recovered satisfactorily, all of them in Child A stage. One died of non-infectious causes (Child C). Infective endocarditis and liver cirrhosis is an infrequent association in clinical practice, it can be associated to unusual agents or clinical manifestations

Scientific Electronic Library Online (Spanish)

174

Effects on growth and biochemical responses in juvenile gilthead seabream ‘Sparus aurata’ after long-term dietary exposure to low levels of dioxins

Ábalos, Manuela; Abad Holgado, Esteban; Estévez, Alicia; Solé, Montserrat; Buet, Astrid; Quirós, Laia; Piña, Benjamín; Rivera, Josep
2008-05-09

Digital.CSIC (Spain)

175

Effects of experimental dicrocoeliosis on oxidative drug metabolism in hamster liver

Sánchez-Campos, S.; Tuñón, M. J.; González, P.; Campo, Raquel; Ferreras, Mª del Carmen; Manga-González, M. Yolanda

6 pages, 2 tables, 2 figures.-- PMID: 8983169 [PubMed].--Available online 25 Jan 2005. | The purpose of this investigation was to determine the effects of experimental dicrocoeliosis on the hepatic oxidative drug-metabolizing system in hamsters. Studies were carried out 80 and 120 days after infesta...

DRIVER (Spanish)

176

Effects of experimental dicrocoeliosis on oxidative drug metabolism in hamster liver

Sánchez-Campos, S.; Tuñón, M. J.; González, P.; Campo, Raquel; Ferreras, Mª del Carmen; Manga-González, M. Yolanda; González-Gallego, J.
1996-09-01

Digital.CSIC (Spain)

177

Effect of zinc supplementation on antioxidant status in rats fasciolosis

Gabrashanska, M.; Tepavitcharova, S.; Manga-González, M. Yolanda; Ermidou-Pollet, S.; Mizinska-Boevska, Y.; Miñambres Rodríguez, Baltasar; Anisimova, M.
2007-01-01

Digital.CSIC (Spain)

178

Effect of supplementation with tribasic zinc or copper salt on the liver antioxidant status in rats with fasciolosis

Manga-González, M. Yolanda; Gabrashanska, M.; Ermidou-Pollet, S.; Mizinska-Boevska, Y.; González Lanza, Camino; Anisimova, M.
2007-06-01

Digital.CSIC (Spain)

179

Effect of mixed basic salts on live performance and trace metals in growing rabbits infected with Fasciola hepatica

Gabrashanska, M. P.; Tsocheva-Gaytandzhieva, N. T.; Tepavitcharova, S. S.; Galvez-Morros, M. M.; Ermidou-Pollet, S. S.

6 pages, 4 tables. | The aim of our study was to assess the effects of mixed basic salts on growth and liver trace metals content of rabbits infected with Fasciola hepatica. Chinchilla rabbits were experimentally infected with Fasciola hepatica and treated with triple hydroxy crystals newly synthesi...

DRIVER (Spanish)

180

Effect of mixed basic salts on live performance and trace metals in growing rabbits infected with Fasciola hepatica

Gabrashanska, M. P.; Tsocheva-Gaytandzhieva, N. T.; Tepavitcharova, S. S.; Galvez-Morros, M. M.; Ermidou-Pollet, S. S.; Pollet, S. A.; Manga-González, M. Yolanda; Anisimova, M.
2006-01-01

Digital.CSIC (Spain)

181

Effect of hypothyroidism on G protein-coupled receptor kinase 2 expression levels in rat liver, lung, and heart

Penela Márquez, Petronila; Barradas, Marta; Álvarez-Dolado, Manuel; Muñoz Terol, Alberto; Mayor Menéndez, Federico
2001-03-01

Digital.CSIC (Spain)

182

Effect of angiotensin II and bradykinin inhibition in rat reduced-size liver transplantation

Padrissa-Altés, Susagna; Franco-Gou, Rosa; Boillot, Olivier; Serafín, Anna; Rimola, Antoni; Arroyo, Vicente; Rodés, Joan; Peralta, Carmen; Roselló Catafau, Joan
2009-02-25

Digital.CSIC (Spain)

183

Effect of 2Gly.ZnCl2.2H2O on antioxidant status in rats under fasciolosis

Gabrashanska, M.; Manga-González, M. Yolanda; Ermidou-Pollet, S.; Anisimova, M.; Tepavitcharova, S.

7 pages, 7 figures. | The aim of our study was to assess the liver antioxidant status (SOD, GPX, vitamins A, C and E, Se, Zn, MDA), body weights and parasite burden in male Wistar rats experimentally infected per os with Fasciola hepatica (25 metaçercariae) and treated with a daily dose of 6 mg 2Gl...

DRIVER (Spanish)

184

Early effects of copper accumulation on methionine metabolism.

Delgado, Miguel; Pérez-Miguelsanz, Juliana; Garrido, Francisco; Rodríguez-Tarduchy, Gemma; Pérez-Sala, Dolores

Wilson’s disease is characterized by long-term hepatic accumulation of copper leading to liver disease with reduction of S-adenosylmethionine synthesis. However, the initial changes in this pathway remain unknown and constitute the objective of the present study. Using the Long Evans Cinnamon rat mo...

DRIVER (Spanish)

185

Early effects of copper accumulation on methionine metabolism.

Delgado, Miguel; Pérez-Miguel sanz, Juliana; Garrido, Francisco; Rodríguez-Tarduchy, Gemma; Pérez-Sala, Dolores; Pajares, María A.
2008-01-01

Digital.CSIC (Spain)

186

EROD induction and PCDD/F levels in fish liver from the Biobio River in Chile

Orrego, Rodrigo; Jiménez, Begoña; Bordajandi, Luisa R.; Gavilán, Juan Francisco; Inzunza, Bárbara; Abad Holgado, Esteban; González, María J.; Rivera, Josep; Barra, Ricardo
2005-03-29

Digital.CSIC (Spain)

187

Diálisis con albúmina MARS (Molecular Adsorbent Recirculating System) como puente para el trasplante hepático en insuficiencia hepática fulminante: presentación de 3 casos/ Albumin dialysis MARS (Molecular Adsorbent Recirculating System) in acute liver failure, before liver transplantation: Report of three cases

Contreras B, Jorge; Poniachik T, Jaime; Oksenberg R, Dan; Cortés M, Claudia; Valera M, José Miguel; Cotera F, Alejandro; Pacheco D, Alejandro; Segovia S, Erico; Sanhueza V, María Eugenia; Boltansky B, Andrés; Rojas C, Jorge; Guerrero, Julia; Díaz J, Juan Carlos
2004-05-01

Resumen en inglés The most successful therapy for acute liver failure is liver transplantation. However, due to the low number of donors, organ support therapies need to be used as a bridge to liver transplantation. Molecular Adsorbents Recirculating System (MARS) is a dialysis treatment that uses a recirculating dialysate containing albumin. This allows the removal of both hydrosoluble and albumin-related substances. This system improves hepatic encephalopathy, renal dysfunction and some (mas) clinical parameters in acute liver failure, but there is no clear decrease in mortality. We report three women aged 23, 21 and 61 years, that were subjected to liver transplantation, in whom this therapy was successfully used (Rev Méd Chile 2004; 132: 601-7)

Scientific Electronic Library Online (Spanish)

188

Differential expression pattern of S-adenosylmethionine synthetase isoenzymes during rat liver development

Gil, Beatriz; Casado, Marta; Pajares, María A.; Boscá, Lisardo; Mato, José M.; Martín-Sanz, Paloma; Álvarez, Luis
1996-09-01

Digital.CSIC (Spain)

189

Diagnóstico y tratamiento de complicaciones biliares tras traumatismo hepático/ Diagnosis and survival management of bile leak complicated after blunt liver injury

Cañete Gómez, J.; Álamo Martínez, J. M.; Muñoz Ortega, A.; Gómez Cabeza de Vaca, V.; Gutiérrez Moreno, M.; Gómez Bravo, M. A.; Suárez Artacho, G.; Bernal Bellido, C.; García González, I.; Barrera Pulido, L.
2008-08-01

Scientific Electronic Library Online (Spanish)

190

Defective TNF-α–mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice

García Ruiz, Carmen; Colell, Anna; Marí, Montserrat; Morales, Albert; Calvo, María; Enrich, Carlos; Fernández Checa, José C.

This study addressed the contribution of acidic sphingomyelinase (ASMase) in TNF-α–mediated hepatocellular apoptosis. Cultured hepatocytes depleted of mitochondrial glutathione (mGSH) became sensitive to TNF-α, undergoing a time-dependent apoptotic cell death preceded by mitochondrial membrane depol...

DRIVER (Spanish)

191

Defective TNF-α–mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice

García Ruiz, Carmen; Colell, Anna; Marí, Montserrat; Morales, Albert; Calvo, María; Enrich, Carlos; Fernández Checa, José C.
2003-01-15

Digital.CSIC (Spain)

192

Daño hepático y enfermedad celíaca/ Liver damage and celiac disease

Cantarero Vallejo, M. D.; Gómez Camarero, J.; Menchén, L.; Pajares Díaz, J. A.; Lo Iacono, O.
2007-11-01

Resumen en español La enfermedad celiaca (EC) es una causa importante de elevación de transaminasas: entre un 5 y un 10% de los pacientes con elevación crónica, criptogénica, de las transaminasas presentan EC y, al contrario, la EC puede estar asociada a diferentes enfermedades hepáticas. En efecto, un amplio abanico de patología hepática puede asociarse a EC, tanto en niños como en adultos, que pueden resumirse en: a) daño hepático mínimo caracterizado por la ausencia de síntom (mas) as o signos clínicos asociables a una enfermedad hepática crónica y con cambios histológicos no específicos que desaparecen después de la introducción de una dieta sin gluten; b) hepatopatías de etiología autoinmune, incluyendo la hepatitis autoinmune, la colangitis esclerosante primaria y la cirrosis biliar primaria, en las que la respectiva evolución no está influenciada por la introducción de dieta sin gluten; y c) insuficiencia hepática grave y cirrosis hepática criptogénica descompensada, potencialmente tratables con la dieta sin gluten. Todas estas patologías están condicionadas por diferentes factores individuales y por una predisposición genética. La progresión y la reversibilidad del daño hepático en los diferentes cuadros patológicos, pueden estar condicionadas por la exposición al gluten y la edad, precoz o tardía, en la cual ha sido introducido en la dieta. Hay suficiente evidencia clínica para recomendar un atento cribado cruzado tanto para el diagnóstico del daño hepático asintomático en los pacientes con EC como para el diagnóstico de la EC en los pacientes con daño hepático criptogénico. Resumen en inglés Celiac disease (CD) is an important cause of serum aminotransferase elevation: between 5 and 10% of patients with persistent and cryptogenetic transaminase elevation may have CD. In fact, a wide spectrum of liver injuries in children and adults may be related to CD, particularly: a) mild parenchymal damage characterized by absence of any clinical signs or symptoms suggesting chronic liver disease, and by non-specific histological changes reversible on a gluten-free diet; (mas) b) chronic liver damage with autoimmune etiology, including autoimmune hepatitis, primary sclerosing cholangitis, and primary biliary cirrhosis, which may be associated with CD but are generally unaffected by gluten withdrawal; and c) severe liver failure and decompensated cryptogenetic liver cirrhosis, potentially treatable with a gluten-free diet. Such different types of liver injuries may represent one same disorder where individual factors, such as genetic predisposition, precocity, and duration of exposure to gluten may influence reversibility of liver damage. A rigorous cross-checking for asymptomatic liver damage in CD individuals and, conversely, for CD in any cryptogenic liver disorder, including end-stage liver failure, is recommended.

Scientific Electronic Library Online (Spanish)

193

Cyclo-oxygenase 2 expression impairs serum-withdrawal-induced apoptosis in liver cells

Fernández-Martínez, Amalia; Mollá, Belén; Mayoral, Rafael; Boscá, Lisardo; Casado, Marta; Martín-Sanz, Paloma

Copyright © by Portland Press. The final version of record is available at http://www.biochemj.org/bj/default.htm | We have investigated the mechanism of COX-2 (cyclo-oxygenase 2)-dependent inhibition of apoptosis in liver, a key pathway underlying proliferative actions of COX-2 in liver cancers, ci...

DRIVER (Spanish)

194

Cyclo-oxygenase 2 expression impairs serum-withdrawal-induced apoptosis in liver cells

Fernández-Martínez, Amalia; Mollá, Belén; Mayoral, Rafael; Boscá, Lisardo; Casado, Marta; Martín-Sanz, Paloma
2006-08-29

Digital.CSIC (Spain)

195

Contribution of gut microbial lysine to liver and milk amino acids in lactating does

Abecia, Leticia; Balcells, Joaquím; Fondevila, Manuel; Belenguer, Álvaro; Holtrop, Grietje; Lobley, Gerald E.

7 pages.-- PMID: 18334044 [PubMed].-- Available online 12 March 2008. | The contribution of microbial amino acids through caecotrophy to tissue protein metabolism was investigated in lactating does. Attempts were made to vary microbial supply through a dietary antibiotic, Zn bacitracin, and to vary ...

DRIVER (Spanish)

196

Contribution of gut microbial lysine to liver and milk amino acids in lactating does

Abecia, Leticia; Balcells, Joaquín; Fondevila, Manuel; Belenguer, Álvaro; Holtrop, Grietje; Lobley, Gerald E.
2008-01-01

Digital.CSIC (Spain)

197

Contribution of cyclooxygenase 2 to liver regeneration after partial hepatectomy

Casado, Marta; Callejas, Nuria A.; Rodrigo, José; Zhao, Xuemei; Boscá, Lisardo; Martín-Sanz, Paloma
2001-09-01

Digital.CSIC (Spain)

198

Constitutive expression of cyclo-oxygenase 2 transgene in hepatocytes protects against liver injury

Mayoral, Rafael; Mollá, Belén; Flores, Juana María; Boscá, Lisardo; Casado, Marta; Martín-Sanz, Paloma

DRIVER (Spanish)

199

Constitutive expression of cyclo-oxygenase 2 transgene in hepatocytes protects against liver injury

Mayoral, Rafael; Mollá, Belén; Flores, Juana María; Boscá, Lisardo; Casado, Marta; Martín-Sanz, Paloma
2008-08-15

Digital.CSIC (Spain)

201

Comparing the response of biochemical indicators (biomarkers) and biological indices to diagnose the ecological impact of an oil spillage in a Mediterranean river (NE Catalunya, Spain)

Damásio, Joana B.; Barata Martí, Carlos; Munné, Antoni; Ginebreda Martí, Antoni; Guasch, Helena; Sabater, Sergi

11 pages, 3 figures, 2 tables.-- PMID: 16959291 [PubMed].-- Online version available Sep 7, 2006. | Three biomarkers of hydrocarbon exposure, liver 7-ethoxyresourfin-O-deethylase activity (EROD), fluorescent hydrocarbon compounds (FACs) in bilis, and the liver antioxidant enzyme catalase (CAT) were ...

DRIVER (Spanish)

202

Characterization of adult and larval stages of Dicrocoelium dendriticum (Trematoda) by enzyme electrophoresis

Campo, Raquel; González Lanza, Camino; Manga-González, M. Yolanda; Rollinson, D.
1992-01-01

Digital.CSIC (Spain)

203

Characterization of 6-phosphofructo-2-kinase from foetal-rat liver

Martín-Sanz, Paloma; Cascales, María; Boscá, Lisardo
1992-01-15

Digital.CSIC (Spain)

204

Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential

Moles, Anna; Tarrats, Núria; Fernández-Checa, José C.; Marí, Montserrat
2009-04-01

Digital.CSIC (Spain)

205

Carcinoma hepatocelular variedad fibrolamelar metastásico en menores de 20 años: Reporte de 2 casos tratados con intención curativa y revisión de la literatura/ Fibrolamellar liver carcinoma: Report of two cases

Butte, Jean M; Waugh, Enrique; Meneses, Manuel; Pruzzo, Rossana; Carvallo, Cristian; Redondo, Francisca; Suárez, Claudio; Parada, Hugo; Amaral, Horacio; de La Fuente, Hernán
2009-03-01

Resumen en inglés Fibrolamellar hepatocellular carcinoma (FLC) is a rare histologic variant of hepatocellular carcinoma that appears most commonly in teenagers andyoung adults. The diagnosis is often made incidentally and surgical resection is the only curative treatment. Here we report two cases of incidental FLC involving a 19 year-old male, initially diagnosed with screening abdominal ultrasound, and a 14 year-old female that presented with abdominalpain. Diagnostic workup consisted of (mas) abdominal PET/CT and MR1Imaging studies and tissue diagnosis was confirmed with percutaneous liver biopsy. Both patients were treated with radical liver resection/tumor excision. However, tumor recurrence was observed in both during short-term follow-up. The male patient was treated successfully with surgical treatment however the female patient succumbed top regression of disease

Scientific Electronic Library Online (Spanish)

207

COX-2 in liver, from regeneration to hepatocarcinogenesis: What we have learned from animal models?

Martín-Sanz, Paloma; Mayoral, Rafael; Casado, Marta; Boscá, Lisardo
2010-03-28

Digital.CSIC (Spain)

209

Blancos terapéuticos potenciales para revertir la cirrosis hepática/ Therapeutical targets for revert liver fibrosis

García B, Leonel; Gálvez G, Javier; Armendáriz B, Juan
2007-06-01

Resumen en inglés Liver fibrosis is the common response to chronic liver injury, ultimately leading to cirrhosis and its complications: portal hypertension, liver failure, hepatic encephalopathy, and hepatocellular carcinoma and others. Efficient and well-tolerated antifibrotic drugs are still lacking, and current treatment of hepatic fibrosis is limited to withdrawal of the noxious agent. Efforts over the past decade have mainly focused on fibrogenic cells generating the scarring response (mas) , although promising data on inhibition of parenchymal injury or reduction of liver inflammation have also been obtained. A large number of approaches have been validated in culture studies and in animal models, and several clinical trials are underway or anticipated for a growing number of molecules. This review highlight recent advances in the molecular mechanisms of liver fibrosis and discusses mechanistically based strategies that have recently emerged

Scientific Electronic Library Online (Spanish)

211

Bacteriemia por Pantoea agglomerans en paciente trasplantado hepático/ Pantoea agglomerans bacteriemia in a liver transplant patient

Morales Ruiz, J.; Espinosa Aguilar, M. D.; López Garrido, M. A.; Nogueras López, F.; Viñolo Ubiña, C.
2010-01-01

Scientific Electronic Library Online (Spanish)

212

Avances en inmunosupresión en trasplante hepático/ Advances in immunossuppression in liver transplantation

Olivera-Martínez, Marco Antonio
2005-04-01

Resumen en español Se ha recorrido mucho camino desde el diseño de la inmunosupresión en la década de los 50's. Desde la utilización de los esteroides y la azatioprina hasta el desarrollo de moléculas humanizadas, que bloquean específicamente receptores de superficie celular para inducir tolerancia del injerto, ha transcurrido medio siglo. El trasplante hepático ha sido uno de los procedimientos más beneficiados con el desarrollo de las nuevas drogas inmunosupresoras y ha dado orige (mas) n a una nueva rama de la medicina: la medicina de trasplantes. También ha sentado las bases de investigación tendiente a lograr la "tolerancia inmunológica" del órgano trasplantado. La piedra angular en la inmunosupresión postrasplante hepático es la utilización de los inhibidores de calcineurina que, en combinación con nuevos antimetabolitos y anticuerpos monoclonales, dibujan un futuro promisorio en la búsqueda de mejores agentes. Resumen en inglés The history of Immunosuppresslon is a long one. From the utilization of steroids and azathloptlne In the 50's to the design of humanized molecules that specifically block cell surface receptors. Liver transplantation is one of the procedures that benefit the most with the development of new immunosuppressors and is also one of the reasons to create a new branch in research and clinical practice: transplant medicine. It also set the standards for research in the "immunolog (mas) ic tolerance" field. The cornerstone in the post-liver transplant stage is the utilization of calcineurin inhibitors combined with new anti-metabolites and monoclonal antibodies. All these settings conforms a promising field in the research of new and better immunosuppressing agents.

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213

Autoradiographic localization of growth hormone binding sites in Sparus aurata tissues using a recombinant gilthead seabream growth hormone

Muñoz-Cueto, J. A.; Martínez-Barberá, Juan P.; Pendón, Carlos; Rodríguez Martínez, Ramón B.; Sarasquete, M.ª Carmen

6 pages. | Growth hormone (GH) binding sites in tissues of gilthead seabream, Sparus aurata, were localized by using an in vitro autoradiographic analysis. Cryomicrotome sections of liver, spleen, kidney, heart and skeletal muscle were mounted on gelatin-coated slides and incubated with a radioiodin...

DRIVER (Spanish)

214

Autoradiographic localization of growth hormone binding sites in Sparus aurata tissues using a recombinant gilthead seabream growth hormone

Muñoz-Cueto, J. A.; Martínez-Barberá, Juan P.; Pendón, Carlos; Rodríguez Martínez, Ramón B.; Sarasquete, M.ª Carmen
1996-05-01

Digital.CSIC (Spain)

216

Assessment of a dual regulatory role for NO in liver regeneration after partial hepatectomy: protection against apoptosis and retardation of hepatocyte proliferation

Zeini, Miriam; Hortelano, Sonsoles; Través, Paqui G.; Gómez-Valadés, Alicia G.; Pujol, Anna; Perales, José C.; Bartrons, Ramón; Boscá, Lisardo
2005-06-01

Digital.CSIC (Spain)

217

Are angiotensin II receptor antagonists useful strategies in steatotic and nonsteatotic livers in conditions of partial hepatectomy under ischemia-reperfusion?

Ramalho, Fernando Silva; Alfany-Fernández, Izabel; Casillas-Ramírez, Araní; Massip-Salcedo, Marta; Serafín, Anna; Rimola, Antoni; Arroyo, Vicente; Rodés, Juan; Roselló Catafau, Joan; Peralta, Carmen
2008-12-30

Digital.CSIC (Spain)

218

Apparatus for diagnosis and monitoring of hepatic steatosis based on electrical impedance measurement

Villa Sanz, Rosa; Guimera Brunet, Antoni; Parramón Capdevila, Damiá; Erill, Iván; Ivorra Cano, Antonio; Aguiló Llobet, Jordi
2008-04-10

Digital.CSIC (Spain)

219

Análisis del resultado de pruebas hepáticas en pacientes psoriáticos tratados con metotrexato: Estudio retrospectivo/ Serum liver tests in patients treated with methotrexate: A retrospective analysis

Correa G, Hernán; Paredes S, Natalia
2007-08-01

Resumen en inglés Background: Methotrexate is one of the best systemic treatments for psoriasis. However it has significant adverse effects such as myelotoxicity and hepatotoxicity. Aim: To evaluate serum liver test in psoríatic patients treated with methotrexate. Material and Methods: Retrospective review of medical records of psoríatic patients treated with methotrexate between the years 2000 and 2005. All patients received a minimum of 7.5 mg weekly of methotrexate, for at ¡east 4 we (mas) eks. Results: Sixty three patients were included. Mean cumulative dose of methotrexate was 576 mg. Thirty two percent had alterations in liver tests, but only 9% had values that duplicated the upper limit of normal range of aminotransferases or alkaline phosphatases or a serum bilirubin over 2 mg/dl. We did not find a direct relationship between the dose of methotrexate and the magnitude of liver test alterations. Only one patient exceeded 1.5 g as cumulative dose. A liver biopsy performed to him, did not show signs of fibrosis. Conclusions: This retrospective study does not show a direct relationship between weekly doses, cumulated dose and length of treatment with methotrexate, and the degree of alteration of serum liver tests (Rev Méd Chile 2007; 135: 1002-8)

Scientific Electronic Library Online (Spanish)

221

Antibiotics threaten wildlife: circulating quinolone residues and disease in avian scavengers

Lemus, Jesús Angel; Blanco, Guillermo; Grande, Javier; Arroyo, Bernardo; García Montijano, Marino; Martínez, Félix
2008-01-16

Digital.CSIC (Spain)

222

Animal models for the study of liver regeneration: role of nitric oxide and prostaglandins

Hortelano, Sonsoles; Zeini, Miriam; Casado, Marta; Martín-Sanz, Paloma; Boscá, Lisardo

DRIVER (Spanish)

223

Animal models for the study of liver regeneration: role of nitric oxide and prostaglandins

Hortelano, Sonsoles; Zeini, Miriam; Casado, Marta; Martín-Sanz, Paloma; Boscá, Lisardo
2007-01-01

Digital.CSIC (Spain)

225

Alternativas terapéuticas actuales de las metástasis hepáticas/ Current therapeutic options for liver metastasis

Martínez C, Jorge; Jarufe C, Nicolás; González D, Robinson; Álvarez Z, Manuel
2008-03-01

Resumen en inglés The liver is a common site of hematogenous metastasis, especially from gastrointestinal malignancies. Liver metastasis are generally classified as stage IV disease. Previously treatment in such patients was met with great skeptiscism. However, advances in surgical and medical therapies during the last two decades have provided effective therapeutic options for selected patients. Since major hepatic resections are now performed with acceptable morbidity and a mortality rat (mas) e

Scientific Electronic Library Online (Spanish)

226

Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer

Isidoro, Antonio; Martínez, Marta; Fernández, Pedro L.; Ortega, Álvaro D.; Santamaría, Gema; Chamorro, Margarita

Recent findings indicate that the expression of the beta-catalytic subunit of the mitochondrial H+-ATP synthase (beta-F1-ATPase) is depressed in liver, kidney and colon carcinomas, providing further a bioenergetic signature of cancer that is associated with patient survival. In the present study, we...

DRIVER (Spanish)

227

Alteraciones hepáticas en pacientes con enfermedades reumáticas/ Hepatic disorders in patients with Rheumatic Diseases

Idrovo, Víctor; Casas, Noemí
2008-12-01

Resumen en español La asociación entre enfermedad reumática y enfermedad hepática está ampliamente reconocida. Se clasifica en tres grandes grupos: Enfermedad hepática asociada a enfermedad reumática. Enfermedad hepática aislada, con enfermedad hepática concomitante. Hepatotoxicidad por el tratamiento médico de la enfermedad reumática. La mayoría de las veces, la hepatopatía asociada no es severa e histológicamente se relaciona con cambios leves inespecíficos o con esteatosis (mas) hepática. La hepatopatía significativa se asocia más con enfermedad hepática concomitante por alcohol o viral, y con hepatotoxicidad medicamentosa. A continuación se presenta una recopilación de estos casos entre 2004 y 2006 de dos centros hospitalarios de Bogotá y de la consulta personal, y una revisión concisa del tema. Resumen en inglés The association between liver diseases and rheumatic diseases is clearly defined. This association can be classified in three groups: Liver disease associated to rheumatic disease. Isolated liver disease, with concomitant hepatic disease. Hepatic liver injury associated to medications for rheumatic disorders. In most of the cases the liver disorder is mild, and is related histologically to subtle non-specific findings or to fatty liver. Significant liver disease in the rh (mas) eumatic population is related to concomitant liver disorders such as viral hepatitis o alcohol disease, or related to drug hepatotoxicity. The following review shows a report of these cases between 2004 and 2006 at two medical centers and from the personal practice of a Hepatology and a rheumatology clinic.

Scientific Electronic Library Online (Spanish)

228

Alcohol, signaling, and ECM turnover

Seth, Devanshi; D’Souza El-Guindy, Nympha B.; Apte, Minoti; Marí, Montserrat; Dooley, Steven; Neuman, Manuela; Haber, Paul S.; Kundu, Gopal C.; Darwanto, Agus; De Villiers, Willem J.; Vonlaufen, A.; Xu, Z.; Phillips, P.; Yang, S.; Goldstein, D.; Pirola, R. M.; Wilson, J. S.; Moles, Anna; Fernández, Anna; Colell, Anna; García Ruiz, Carmen; Fernández Checa, José C.; Meyer, Christoph; Meindl-Beinker, Nadja M.
2010-01-01

Digital.CSIC (Spain)

229

Adenoma hepático gigante en varón de 64 años/ Giant liver-cell carcinoma in a 64 years old male

Huguet, J. M.; Cors, R.; Bort, I.; Rodríguez, E.; Carbonell, P.; González, C.; Diago, M.; Medina, E.
2006-01-01

Scientific Electronic Library Online (Spanish)

230

Active-site-mutagenesis study of rat liver betaine–homocysteine S-methyltransferase

González, Beatriz; Campillo, Nuria; Garrido, Francisco; Gasset, María; Sanz-Aparicio, Juliana; Pajares, María A.
2003-03-01

Digital.CSIC (Spain)

231

Activation of peroxisome proliferator-activated receptor-α inhibits the injurious effects of adiponectin in rat steatotic liver undergoing ischemia–reperfusion

Massip-Salcedo, Marta; Zaouali, M. Amine; Padrissa-Altés, Susagna; Casillas-Ramirez, Arani; Rodés, Joan; Roselló Catafau, Joan; Peralta, Carmen
2007-12-20

Digital.CSIC (Spain)

232

Activation of alveolar macrophages in lung injury associated with experimental acute pancreatitis is mediated by the liver

Closa, Daniel; Sabater, Luis; Fernández Cruz, Laureano; Prats, Neus; Gelpí, Emili; Roselló Catafau, Joan

[OBJECTIVE] To evaluate (1) whether alveolar macrophages are activated as a consequence of acute pancreatitis (AP), (2) the implication of inflammatory factors released by these macrophages in the process of neutrophil migration into the lungs observed in lung injury induced by AP, and (3) the role ...

DRIVER (Spanish)

233

Activation of alveolar macrophages in lung injury associated with experimental acute pancreatitis is mediated by the liver

Closa, Daniel; Sabater, Luis; Fernández Cruz, Laureano; Prats, N.; Gelpí, Emili; Roselló Catafau, Joan
1999-02-01

Digital.CSIC (Spain)

234

Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor–induced lethal hepatitis

Marí, Montserrat; Colell, Anna; Morales, Albert; García Ruiz, Carmen; Fernández Checa, José C.; Varela-Nieto, Isabel

S-adenosyl-L-methionine (SAM) is synthesized by methionine adenosyltransferases (MATs). Ablation of the liver-specific MAT1A gene results in liver neoplasia and sensitivity to oxidant injury. Here we show that acidic sphingomyelinase (ASMase) mediates the downregulation of MAT1A by TNF-α. The levels...

DRIVER (Spanish)

235

Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor–induced lethal hepatitis

Marí, Montserrat; Colell, Anna; Morales, Albert; García Ruiz, Carmen; Fernández Checa, José C.; Varela-Nieto, Isabel; Pañeda, Covadonga
2004-03-15

Digital.CSIC (Spain)

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237

Absceso hepático: Serie de 107 casos y revisión de la literatura/ Hepatic abscess: Series of 107 cases and literature review

Fantuzzi S, Andrés; Albertz A, Nicolás; Valenzuela V, Antonia; Estuardo A, Nivia; Castro L, Ariel
2009-02-01

Resumen en español El absceso hepático es una patología infrecuente con alta morbimortalidad. Objetivo y método: Describir los casos de absceso hepático en el Hospital Clínico de la Universidad de Chile entre los años 2000 y 2007 y revisión de la literatura respecto del tema. Resultados: En 107 casos revisados, la edad promedio fue 59 años. Los síntomas más frecuentes fueron fiebre y dolor abdominal con una duración promedio de 19 días. El 25% de los casos presentaba como co-mor (mas) bilidad diabetes mellitus tipo 2, un 7% era inmuno suprimido y 24% había sido sometido a procedimiento invasor previo. No se logró identificar el origen en la mayoría de los casos. El estudio de imagen más solicitado fue la TC de abdomen. En 49/75 (65,3%) se estableció la etiología mediante el cultivo del absceso. Se constató bacteriemia en 17/68 (25%) pacientes. La mayoría de los casos se trataron con dos o más antimicrobianos y drenaje percutáneo. Conclusión: Las características de los casos de absceso hepático encontradas en este estudio concuerdan con lo descrito en la literatura médica Resumen en inglés Liver abscess is a rare disease with high morbidity and mortality. Objective and Method: Description of liver abscess cases attended in the Universidad de Chile Clinical Hospital between 2000 and 2007 and review of the literature on the topic. Results: For 107 cases reviewed, mean age was 59 years. Most common symptoms were fever and abdominal pain with an average duration of 19 days. Comorbidity: twenty five percent of patients had Diabetes Mellitus type 2, seven percent (mas) were immunosuppressed patients and 24% had undergone invasive procedures. Not achieved identify the origin in most cases. The most requested image test was abdominal CT. In 49/75 (65.3%) the abscess culture allowed to establish the etiology. Bacteremia was present in 17/68 (25%) of cases. Most cases were treated with two or more antibiotics and percutaneous drainage. Conclusion: Clinical manifestations and resolution of liver abscess in this series are consistent with those described in the literature

Scientific Electronic Library Online (Spanish)

240

"Síndrome pequeño para su tamaño", (small-for-size), como complicación de un trasplante hepático con donante vivo adulto relacionado/ Small-for-size syndrome. Report of one case

Yarur, Andrés; Castro, Lorena; Segovia, Roberto; Roblero, Juan Pablo; Uribe, Mario; Ferrario, Mario; Buckel, Erwin
2009-07-01

Resumen en inglés Although the use of cadaveric split or living donor liver transplantation is a valid option for liver transplants, they have several complications, being the "small-for-size syndrome" one of the most frequent. This entity is mainly due to the incapacity that the graft has to meet the blood drainage demands. We report a 61 year-old patient with sub-acute liver failure, transplanted with a partial liver graft that developed hyperbilirubinemia, ascites and liver function det (mas) erioration. A meso-caval shunt was performed, after which the ascites resolved, serum bilirubin normalized and the synthetic function of the liver improved. After one month, a follow-up CT seen showed the absence of blood flow in the shunt, possible due to the reduction of the hyper-perfusion of the liver. The clinical and biochemical condition of the patient continued improving despite the lack of flow through the shunt

Scientific Electronic Library Online (Spanish)