Sample records for HISTONAS (histones)
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2

Epigenética en asma/ Epigenetics in asthma

Vergara Rivera, Candelaria; Sánchez Caraballo, Jorge Mario; Martínez Alfaro, Beatriz; Caraballo Gracia, Luis
2009-12-01

Resumen en español El asma es una enfermedad respiratoria crónica con alta heredabilidad. Se ha propuesto que en su patogénesis participan varios genes con efectos variables al igual que factores ambientales, y se ha sugerido que los mecanismos epigenéticos pueden mediar parte del efecto de los factores ambientales en el comienzo y la evolución de la enfermedad. La epigenética describe los cambios en la expresión génica heredables durante las mitosis y meiosis que no son codificados (mas) en la secuencia de ADN. Ellos incluyen la metilación o desmetilación del ADN y la acetilación, desacetilación, ubiquitinación, sumoilación y fosforilación de histonas, cambios en los microARN y alteraciones cromatínicas. En esta revisión se describen hallazgos que establecen una relación entre algunos mecanismos epigenéticos y el proceso inflamatorio y la exposición a factores ambientales en el asma. Ellos incluyen: el aumento en la actividad de las acetilasas de histonas y de la expresión de las enzimas acetiladoras; la disminución de las enzimas desacetiladoras en los pulmones de individuos asmáticos; el aumento de la expresión del factor nuclear NF-?B durante el proceso inflamatorio alérgico; cambios en la metilación/desmetilación del ADN durante la diferenciación de los linfocitos y la estimulación/supresión de genes como los de la IL-4 y el IFN-?, respectivamente. El humo del cigarrillo, las infecciones bacterianas y virales, la dieta materna y la polución ambiental son otros factores que desencadenan procesos epigenéticos como la acetilación de histonas, la inducción de citoquinas inflamatorias, la inactivación de las desacetilasas de histonas, la polarización de la respuesta inmune hacia el tipo Th2 y una mayor producción de IgE y citoquinas de este perfil. Se revisan también los efectos epigenéticos resultantes de la terapia con corticoides y teofilina y otros factores que podrían influir en el riesgo de asma en la infancia como la ingesta materna de frutas, legumbres, aceites de pescado, vitaminas, minerales y probióticos y el uso de antibióticos durante el embarazo. Resumen en inglés Epigenetics in asthma Asthma is a chronic respiratory disease with a high heritability. It has been postulated that several genes with variable effects are involved in its pathogenesis along with environmental factors. It has been suggested that epigenetic mechanisms can mediate the effects of environmental factors on the onset and progression of the disease. Epigenetics describes inheritable changes in gene expression inherited during meiosis and mitosis that are not enc (mas) oded in the DNA sequence. They include DNA methylation/ demethylation, acetylation, deacetylation, ubiquitination, SUMOylation and phosphorylation of histones, changes in microARN and alterations of chromatine. In this article we review some findings that establish a relationship between some epigenetic mechanisms and the inflammatory process in asthma and exposure to environmental factors. They include increasing the activity of histone acetyl-transferases and the expression of histone acetylating enzymes, decrease of deacetylating enzymes in the lungs of asthmatics; increased expression of the transcription factor NF-?B in the allergic inflammatory process, changes in methylation/demethlylation of DNA during the differentiation of lymphocytes and the stimulation/ suppression of IL-4 and IFN? genes, respectively. Smoking, bacterial and viral infections, maternal diet and environmental pollution are also factors that trigger epigenetic processes such as histone acetylation and induction of inflammatory cytokines, inactivation of histone deacetytransferases, polarization of the immune response toward the Th2 type and increased production of IgE and cytokines of this profile. We review the epigenetic effects resulting from therapy with corticosteroids and theophylline, and other factors that might influence the risk of asthma in childhood such as maternal intake of fruits, vegetables, fish oils, vitamins, minerals, and the use of probiotics and antibiotics during pregnancy.

Scientific Electronic Library Online (Spanish)

3

Análisis molecular del proceso de transcripción de genes en eucariontes/ Molecular analysis of genome transcription in eukaryotes

Cabrejos M, María Eugenia; Tamayo C, Evelyn; Maldonado M, Edio
2001-09-01

Resumen en español El proceso de transcripción es altamente regulado en el que intervienen la RNA polimerasa y varios factores adicionales. La enzima RNA polimerasa II contiene entre 8 y 14 subunidades y es la enzima que transcrie los RNA que codifican para proteínas. La subunidad mayor de la RNA polimerasa II contiene en su región carboxilo terminal un dominio denominado CTD que consiste en repeticiones de un heptapéptido, el cual es fundamental para la regulación de la transcripción (mas) . El proceso de transcripción consiste de tres etapas: iniciación, elongación y terminación. A pesar que la RNA polimerasa II es una enzima multimérica, no puede reconocer los promotores e iniciar la transcripción en forma específica. Para iniciar la transcripción en forma específica requiere de factores adicionales, denominados factores generales de transcripción, los cuales se denominan TFIIA, TFIIB, TFIID, TFIIE, TFIIF y TFIIH. Estos factores y la RNA polimerasa II se ensamblan sobre el promotor en forma secuencial, o preensamblados con la RNA polimerasa II. Los genes son activados en respuesta a señales fisiológicas, llevada a cabo por los activadores de la transcripción, los que se unen a secuencias intensificadoras que están ubicadas río arriba del sitio de iniciación. Para la activación de la transcripción, además de los activadores, se requiere de un complejo MED, el cual puede encontrarse libre o bien unido al CTD de la RNA polimerasa II. El DNA se encuentra compactado dentro del núcleo por histonas, las cuales representan un impedimento físico para que se forme un complejo de iniciación sobre el promotor. Existen enzimas que poseen la capacidad de modificar las histonas, que se denominan acetilasas, las cuales acetilan el dominio aminoterminal de las histonas, provocando una inestabilidad en el nucleosoma, lo cual permite que se forme un complejo de preiniciación de la transcripción. También existen factores que son capaces de desplazar los nucleosomas para permitir la unión de la RNA polimerasa II y sus factores al promotor Resumen en inglés The transcription process is highly regulated and requires RNA polymerase and additional factors. The enzyme RNA polymerase II is composed of 8 to 14 subunits and transcribes the messenger RNA. The largest subunit contains in the amino terminal region a domain which is named CTD. CTD is composed of repetitions of a heptapeptide sequence which is fundamental for the regulation of transcription. Although RNA polymerase is a multimeric enzyme it is not by itself able to reco (mas) gnize the promoters and initiate specific transcription. It requires auxiliary factors called the general transcription factors, TFIIA, TFIIB, TFIID, TFIIE, TFIIF and TFIIH. These factors and RNA polymerase II are assembled at the promoter site in a step by step fashion or preassembled with RNA polymerase II. The genes are activated in response to physiological signals by activators which bind to the upstream elements of the promoter site. Also for the activation of transcription the MED complex is required. This can exist in the free form or bound to the CTD of RNA polymerase II. The DNA inside the nucleus is compacted by histones to form chromatin, which restricts the access of the transcription machinery to the promoter site. Enzymes called acetylases are able to modify the chromatin structure by acetylation of the N-terminal of the histones, producing a weakening in the DNA-histone contacts, thus allowing the transcription machinery access to the promoters and initiate transcription. There exists factors which are able to displace the nucleosomes to allow RNA polymerase II and factors to form a preinitiation complex on the DNA promoter site

Scientific Electronic Library Online (Spanish)

4

Metilación del ADN: un fenómeno epigenético de importancia médica/ DNA methylation: an epigenetic process of medical importance

Rodríguez Dorantes, Mauricio; Téllez Ascencio, Nelly; Cerbón, Marco A.; López, Marisol; Cervantes, Alicia
2004-02-01

Resumen en español La metilación del ADN en dinucleótidos CpG es uno de los mecanismos epigenéticos implicados en la regulación de la expresión génica en mamíferos. Los patrones de metilación son específicos para cada especie y tipo de tejido. La maquinaria implicada comprende diferentes proteínas reguladoras incluyendo a las ADN metiltransferasas, desmetilasas putativas, proteínas de unión a CpG metilados, enzimas modificadoras de histonas y complejos remodeladores de la cromat (mas) ina. La metilación del ADN es de vital importancia para mantener el silenciamiento génico en el desarrollo normal, la impronta genómica y la inactivación del cromosoma X. En contraste, alteraciones en ella están implicadas en algunas enfermedades humanas, especialmente aquéllas relacionadas con defectos en el desarrollo y el proceso neoplásico. Esta revisión resume los aspectos moleculares de la metilación del ADN y su participación en el desarrollo normal, el cáncer y en algunas patologías humanas en las que los mecanismos epigenéticos han sido implicados. El conocimiento de las modificaciones epigenéticas que ocurren en las enfermedades humanas será importante para su manejo futuro. Los cambios en los patrones de metilación podrán ser empleados como marcadores en cáncer y el estado potencialmente reversible de este proceso constituye un blanco ideal para crear estrategias terapéuticas que impliquen la reactivación o el re-silenciamiento de genes específicos. Resumen en inglés Methylation of CpG dinucleotides is an epigenetic mechanism involved in the regulation of gene expression in mammals. The patterns of CpG methylation are specie and tissue specific. The biological machinery of this system comprises a variety of regulatory proteins including DNA methyltransferases, putative demethylases, methyl-CpG binding proteins, histones modifying enzymes and chromatin remodeling complexes. DNA methylation maintains gene silencing and participates in n (mas) ormal development, genomic imprinting and X chromosome inactivation. In contrast, alterations in DNA methylation participate in the induction of some human diseases, especially those involving developmental defects and tumorigenesis. This review summarizes the molecular aspects of DNA methylation and its implications in cancer and other human diseases in which this epigenetic mechanism has been involved. Our understanding of the epigenetic changes that occur in human diseases will be very important for future management. Changes in the patterns of methylation can be used as markers in cancer and their potentially reversible state creates a target for therapeutic strategies involving specific gene re-activation or re-silencing.

Scientific Electronic Library Online (Spanish)

5

Detección de anticuerpos anti-núcleo con inmunoensayo lineal: Correlación con inmunofluorescencia indirecta/ Anti-nucleus antibodies detection by line immunoassay. Correlation with indirect immunofluorescence

Bovone, Nora Silvia; Fuente, María Cristina; Eposto, Mario Omar; Londero, Paula
2005-12-01

Resumen en español La prueba usada como screening para la detección de autoanticuerpos en enfermedades sistémicas del tejido conectivo es la inmunofluorescencia indirecta (IFI) sobre células Hep-2. No obstante, para identificar el perfil de anticuerpos específicos se emplean métodos adicionales como doble difusión, immunoblotting, ELISA o inmunoensayo lineal (LIA). El objetivo del presente estudio fue: a) Evaluar la probabilidad de detectar reactividad fina por un LIA comercial sobre (mas) muestras de suero que resultaron IFI positivas en el screening y b) Estudiar su correlación con los patrones y títulos observados. Para ello fueron retrospectivamente seleccionadas 161 muestras de suero positivas por IFI que también fueron procesadas por LIA. Se emplearon improntas de Hep-2 (Kallestad) y equipo comercial Innolia-ANA de Innogenetic. Además, 60 de estas muestras fueron estudiadas para anti ácido desoxirribonucleico nativo (anti-dsADN) por IFI sobre improntas de Crithidia Lucillae (Kallestad). En las muestras con patrón homogéneo la positividad por LIA fue del 60% con prevalencia de anti-histonas y anti-dsADN. Se destaca el hallazgo de anticuerpos anti-ENA (antígenos nucleares extraíbles) en este grupo. La positividad del patrón moteado fue del 73%. La imagen moteada se asoció en forma más contundente a la presencia de anticuerpos anti-ENA, la imagen homogénea aportó escasa información respecto del perfil de anticuerpos específicos dada la elevada prevalencia de anti-ENA en estas muestras. El patrón centromérico no necesita confirmación. La probabilidad de encontrar reactividad fina por LIA se incrementa con el aumento de título informado, quedando justificada su búsqueda aun en muestras con bajo título de anticuerpos. Resumen en inglés The most used screening test to detect autoantibodies in systemic diseases is indirect immunofluorescence (IIF) with Hep-2 cells. However, additional methods, such as double diffusion, immunoblotting, ELISA or line immunoassay (LIA), are used to identify specific antibodies profiles. The aim of this study was: a) To asses the probability of fine detection by a commercial LIA on serum samples that resulted positive by IIF screening and b) To asses the correlation between t (mas) he patterns and titles observed. A hundred and sixty-one serum samples positive by IIF that had also been processed by LIA were selected. Hep-2 slides of Kallestad and commercial kit Innolia-ANA of Innogenetics were used. Sixty samples were also studied for anti-dsDNA by IIF with Crithidia Lucilliae slides of Kallestad. Sixty per cent of the samples with homogeneus pattern were positive by LIA, with a prevalence of anti-histones and anti-dsDNA. The finding of antibodies anti-ENA in this group was important. In the speckle sample, 73% were positive. In detecting anti-ENA, speckle sample was more forceful than homogeneous pattern which showed little information about a specific antibodies profile. Anticentromere pattern did not need confirmation. The probability of finding fine reactivity by LIA is increased with the rise in title, but its search for low titles is still justified.

Scientific Electronic Library Online (Spanish)

6

La epigenética y los estudios en gemelos en el campo de la psiquiatría/ Epigenetics and twin studies in psychiatric domains

González Ramírez, Adriana Estrella; Díaz Martínez, Alejandro; Díaz-Anzaldúa, Adriana
2008-06-01

Resumen en español La secuencia de ADN genómico que caracteriza a nuestra especie constituye la piedra fundamental de la vida humana; parte de ella se refleja en la secuencia del ARN y a través de éste se dicta la información necesaria para que nuestras células produzcan proteínas. La genética contribuye de manera importante a los avances en el campo médico. Los descubrimientos genéticos han permitido desarrollar estrategias para modificar, prevenir y proponer nuevas terapias para (mas) diversas enfermedades. En el siglo XIX, Gregor Johann Mendel desarrolló un modelo teórico capaz de predecir la naturaleza y propiedades de los mecanismos de la herencia, que sigue siendo indispensable para explicar la base de la herencia humana. Otro suceso determinante en la historia de la Medicina se dio a conocer casi nueve décadas después cuando James Watson y Francis Crick describieron su modelo estructural para el ADN. Posteriormente se introdujeron la clonación posicional y la reacción en cadena de la polimerasa; más recientemente se publicó cerca del 99% de la secuencia del genoma humano. El período actual se conoce como la era post-genómica, ya que además de descifrar genomas completos, los investigadores pretenden, entre otras cosas, esclarecer los mecanismos que influyen en la activación e inactivación de los genes, lo cual en parte involucra un nivel epigenético. En las ciencias médicas los gemelos constituyen un grupo idóneo para abordar el estudio de las enfermedades hereditarias. En este tipo de padecimientos suelen observarse similitudes entre parientes, en especial si se trata de gemelos monocigóticos. Sin embargo, aun en este tipo de hermanos se detectan diferencias importantes. Parámetros como los grados de concordancia y porcentajes de heredabilidad han puesto de manifiesto que un gemelo monocigótico puede presentar trastornos hereditarios que su co-gemelo nunca tendrá. La epigenética es el estudio de los cambios en la función de los genes que no afectan la secuencia del ADN, por modificaciones que tienen lugar principalmente en las citosinas de éste y en las histonas de la cromatina. Se ha determinado que las modificaciones epigenéticas son mucho más frecuentes que aquellas que modifican la secuencia del ADN, por lo que constituyen uno de los fundamentos de la diversidad biológica, muestran la manera en que el ambiente puede modular la expresión genética y contribuyen así a nuestro fenotipo. Esta revisión reúne datos sobre la posible relevancia de la epigenética en el estudio de los trastornos mentales y como posible explicación parcial de las diferencias observadas entre gemelos >. Un conocimiento más profundo de los patrones epigenéticos podría contribuir a identificar factores de riesgo para estos trastornos. Resumen en inglés The sequence of the human genome integrates the keystone of our life. Part of it is transcribed to RNA, which in turn provides the information required by our cells to produce proteins. Discoveries in the genetics field have been essential to medicine and have been used to develop strategies to modify, prevent and propose new therapeutic approaches for human diseases. In the 19th Century, Gregor Johann Mendel developed a theoretical model which was able to predict in an a (mas) ccurate way hereditary mechanisms; indeed, his laws still explain the basis of human inheritance. Almost ninety years later, James Watson and Francis Crick announced their double-helix model of the DNA molecule. Then, positional cloning and the polymerase chain reaction (PCR) were introduced; more recently, almost 99% of the sequence of our genome was made public. The current period of time is known as the post-genomic era, due to the fact that researchers are not only obtaining the complete sequences of thousands of genomes, but are also searching for clues that may help understand the mechanisms that affect gene activation and deactivation, in which epigenetic factors are also involved. In medical domains, twins constitute a suitable group to study inherited disorders. Dizygotic or fraternal twins are produced by different egg and sperm cells, and even when these two fertilization events occur simultaneously, dizygotic twins share approximately the same percentage of genetic material than any pair of siblings, that is, around 50%. Some authors have suggested that the tendency for spontaneous dizygotic twinning could be attributed to a double ovulation which is genetically determined in an autosomal dominant manner. Monozygotic, as opposed to dizygotic twins, are produced by a single zygote whose cells are dissociated and originate two independent organisms; approximately a third of monozygotic twins are separated before the 5th day after fertilization, and the rest between the 5th and the 15th day. Most monozygotic twins are very similar; nevertheless, some few exceptions prove that in fact they actually do not have to be identical. Relatives of a person with a mental disorder tend to share traits associated with this disease, especially if the patient and the relative are monozygotic twins. However, important differences may be detected even between each pair of identical twins. Parameters such as concordance and heritability have shown that a monozygotic twin can develop an inherited disorder while his or her co-twin will always be disease-free. In addition to differences in susceptibility to inherited diseases, this kind of twins can display dissimilarities in somatic cell mutations (more overtly noticeable when ageing), their set of antibodies and T cell receptors, their number of mitochondrial DNA molecules, and chromosome X inactivation patterns in women, all of which are the main subject of many ongoing studies. A recent report shows that from 160 monozygotic twin pairs who were 3 to 74 years old, epigenetic patterns were identical early in life, but differences were more obvious at older ages, especially if twins were raised apart or if they had different medical history. Medical conditions, but also environmental factors such as pregnancy tobacco exposure, physical activity, and diet could contribute to differences in epigenetic patterns. It has been shown that epigenetic modifications (or epi-mutations) are more frequent than the ones that modify DNA sequence, so they are part of the fundamental causes of biological diversity, and they show how environment can modulate gene expression and contribute to our phenotype. Even when twin studies are sometimes considered purely genetic, they also give information about the influence of environmental factors. However, it is important to consider with caution the results from this type of studies. Heritability estimates are not unchangeable facts. They depend on the sample being analyzed, the genes involved in the specific sample, the characteristics of the environmental factors which members of this group were exposed to, and the precise moment the study was done. Epigenetics refers to changes that do not alter the DNA sequence but affect gene function due to chemical modifications which mainly occur in DNA cytosines and in chromatin-related histones. Epigenetic processes are covalent modifications which include the addition of functional groups (methyl, acetyl, phosphate, etc.) or proteins (ubiquitin, SUMO, etc.) to the DNA molecule or to associated proteins. These modifications contribute to the activation or inhibition of transcription, which leads to changes in messenger ARN expression that can ultimately influence the onset of disease. Pseudogenes are still being excluded while new genes are being confirmed in our genome sequence, but the current estimates indicate that each one of our nucleated cells contains almost 22000 genes (excluding mitochondrial DNA) which encode for polypeptides and more than 4,000 whose final product is RNA. Gene expression is partially controlled by DNA coiling around globular proteins called histones, which constitute a structure known as chromatin, a DNA-protein complex that represents the packaging of 3.25 billion base pairs of our genetic information. Physical and chemical chromatin modifications can also affect gene expression by changing DNA-protein interactions; in general terms, genes are inhibited when chromatin is packed and they are active when it is free. These dynamic states are controlled by epigenetic reversible modifications on DNA methylation or by changes in histones. It has been shown that subtle epigenetic differences between any two human beings are associated with dissimilar final chromatin remodeling, as well as expression/repression of genes.

Scientific Electronic Library Online (Spanish)

7

Vaccinia-related kinase (VRK) signaling

Sanz-García, Marta; Valbuena, Alberto; López-Sánchez, Inmaculada; Blanco, Sandra; Fernández, Isabel F.; Vázquez-Cedeira, Marta; Lazo, Pedro A.
2010-01-01

Digital.CSIC (Spain)

8

The p75NTR-interacting protein SC1 inhibits cell cycle progression by transcriptional repression of cyclin E

Pérez González, Pilar; Chittka, Alexandra; Arévalo, Juan Carlos; Rodríguez-Guzmán, María; Chao, Moses V.; Sendtner, Michael
2004-03-01

Digital.CSIC (Spain)

10

The functional modulation of epigenetic regulators by alternative splicing

Lois, Sergi; Blanco, Noemí; Martínez-Balbás, Marian; Cruz, Xavier de la
2007-07-25

Digital.CSIC (Spain)

11

The SV40 T antigen modulates CBP histone acetyltransferase activity

Aragón Valls, Esther; Cruz, Xavier de la; Martínez-Balbás, Marian
2003-06-15

Digital.CSIC (Spain)

12

TSH signalling and cancer

García-Jiménez, Custodia; Santisteban, Pilar
2007-01-01

Digital.CSIC (Spain)

13

Synaptonemal complex assembly and H3K4Me3 demethylation determine DIDO3 localization in meiosis

Prieto, Ignacio; Kouznetsova, Anna; Fütterer, Agnes; Trachana, Varvara; Leonardo, Esther; Alonso Guerrero, Astrid; Cano Gamero, Mercedes; Pacios-Bras, Cristina; Leh, Hervé; Buckle, Malcolm; Gracía-Gallo, Mónica; Kremer, Leonor; Serrano, Antonio; Roncal, Fernando; Albar, Juan Pablo; Barbero, José Luis; Martínez-Alonso, Carlos; Van Wely, Karel H. M.
2009-10-01

Digital.CSIC (Spain)

16

Sobre el origen ontogénico del ser humano: La solución científica/ On the ontogenetic origin of human beings: The scientific solution

Valenzuela, Carlos Y
2007-01-01

Resumen en inglés Every living being is the result of a genome-environment interaction. Neither human oocytes nor spermatozoids have human functional genomes, but the zygote that they constitute may have a human functional genome and other functional genomes such as those of the hydatidiform mole, polyploids, and non-human living beings. When the zygotic human functional genome is integrated and activated, the biotic humanity is acquired. This may occur when the paternal chromatin deconden (mas) ses; the nuclear environment and envelope of both nuclei are changed to constitute pronuclei; the replacement of sperm protamines by histones; genome imprinting modifications; centriole duplication; and more importantly, the fourfold genome replication. Other propositions on the origin of humans are: embryo implantation [6-7 days post fertilization, (dpf)]; the appearance of the antero-posterior axis; the limit for monozygote twining (13dpf) and the appearance of the neural tissue (16dpf). They are refuted because some mammals do not implant; embryo axes are present in the zygote; some animals regenerate complete individuals from each part in which they are divided; plants do not have neural system; a human whose brain was destroyed by cancer continues to be a human. Alternative propositions coming from philosophies, theologies, perceptive knowledge, beliefs and intuitions and based on conceptualizations like person, anima, soul, organization, socio-cultural relations are ideologically or religiously biased and based on irreducible beliefs such as faith. They lead to disagreement rather than to agreement

Scientific Electronic Library Online (Spanish)

17

Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex

Peinado, Héctor; Ballestar, Esteban; Esteller, Manel; Cano García, Amparo
2004-01-01

Digital.CSIC (Spain)

18

Removal of nuclear contaminants and of non-specifically photosystem II-bound copper from photosystem II preparations

Arellano, Juan B.; Schröder, Wolfgang P.; Sandmann, Gerhard; Chueca, Ana; Barón, Matilde

In conventional photosystem II preparation high amounts of Cu are found. After fractionation by centrifugation, Cu can be completely removed from photosystem II without affecting either its photosynthetic activity or the composition of its specific proteins. We could demonstrate that the Cu was asso...

DRIVER (Spanish)

19

Removal of nuclear contaminants and of non-specifically photosystem II-bound copper from photosystem II preparations

Arellano, Juan B.; Schröder, Wolfgang P.; Sandmann, Gerhard; Chueca, Ana; Barón Ayala, Matilde
1994-07-01

Digital.CSIC (Spain)

20

Relationship between Core Histone Acetylation and Histone H10 Gene Activity

Girardot, Valérie; Rabilloud, Thierry; Yoshida, Minoru; Beppu, Teruhiko; Lawrence, Jean-Jacques; Khochbin, Saadi
1994-09-15

Digital.CSIC (Spain)

21
25

Phylogenetic analysis of Verticillium dahliae vegetative compatibility groups

Collado-Romero, M.; Mercado-Blanco, Jesús; Olivares-García, Concepción; Jiménez-Díaz, Rafael M.
2008-09-01

Digital.CSIC (Spain)

27

Mechanisms of P/CAF auto-acetylation

Santos Rosa, Helena; Kouzarides, Tony; Martínez-Balbás, Marian
2003-08-01

Digital.CSIC (Spain)

28

Maintenance of Undifferentiated State and Self-Renewal of Embryonic Neural Stem Cells by Polycomb Protein Ring1B

Román-Trufero, Mónica; Méndez-Gómez, Héctor R.; Pérez, Claudia; Hijikata, Atsushi; Fujimura, Yu-ichi; Endo, Takaho; Koseki, Haruhiko; Vicario-Abejón, Carlos; Vidal, Miguel
2009-04-02

Digital.CSIC (Spain)

29

Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity

Cabrero, J. Román; Serrador, Juan M.; Barreiro, Olga; Mittelbrunn, María; Naranjo-Suárez, Salvador; Martín-Cófreces, Noa; Vicente-Manzanares, Miguel; Mazitschek, Ralph; Bradner, James E.; Avila, Jesús; Valenzuela-Fernández, Agustín; Sánchez-Madrid, Francisco
2006-05-31

Digital.CSIC (Spain)

30

Key role of the 3' untranslated region in the cell cycle regulated expression of the Leishmania infantum histone H2A genes: minor synergistic effect of the 5' untranslated region

Abanades, Daniel R.; Ramírez, Laura; Iborra, Salvador; Soteriadou, Ketty; González, Víctor Manuel; Bonay, Pedro; Alonso, Carlos; Soto, Manuel
2009-05-21

Digital.CSIC (Spain)

31

Infectious Bursal Disease Virus: Ribonucleoprotein Complexes of a Double-Stranded RNA Virus

Luque, Daniel; Saugar, Irene; Rejas, María Teresa; Carrascosa, José L.; Rodríguez, José F.; Castón, José R.

Genome-binding proteins with scaffolding and/or regulatory functions are common in living organisms and include histones in eukaryotic cells, histone-like proteins in some double-stranded DNA (dsDNA) viruses, and the nucleocapsid proteins of single-stranded RNA viruses. dsRNA viruses nevertheless la...

DRIVER (Spanish)

32

Infectious Bursal Disease Virus: Ribonucleoprotein Complexes of a Double-Stranded RNA Virus

Luque Buzo, Daniel; Saugar, Irene; Rejas, María Teresa; Carrascosa, José L.; Rodríguez Aguirre, José F.; Castón, José R.
2009-02-27

Digital.CSIC (Spain)

34

HDAC and Hsp90 Inhibitors Down-Regulate PTTG1/Securin But Do Not Induce Aneuploidy

López Lluch, Guillermo; Hernández, Agustín; Navas, Plácido; Pintor-Toro, José Antonio
2008-11-11

Digital.CSIC (Spain)

35

Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras

Goeman, Frauke; Thormeyer, Dorit; Abad, María; Serrano, Manuel; Schmidt, Oliver; Palmero, Ignacio; Baniahmad, Aria
2005-01-01

Digital.CSIC (Spain)

37
38

Functional equivalence of HMGA- and histone H1-like domains in a bacterial transcriptional factor

García-Heras, Francisco; Padmanabhan, Subramanian; Murillo, Francisco J.; Elías-Arnanz, Montserrat
2009-07-27

Digital.CSIC (Spain)

41

Dissociation of protamine-DNA complexes by Xenopus nucleoplasmin and minichromosome assembly in vitro

Ruíz Lara, Simón A.; Cornudella, Lluís; Rodríguez Campos, Antonio
1996-08-15

Digital.CSIC (Spain)

44

DNA sequence-specific recognition by a transcriptional regulator requires indirect readout of A-tracts

Mendieta, Jesús; Pérez-Lago, Laura; Salas, Margarita; Camacho, Ana
2007-04-22

Digital.CSIC (Spain)

46

Contribution of histones H2A and H2B to the folding of nucleosomal DNA

Jordano, Juan; Montero, F.; Palacián, Enrique
1984-01-01

Digital.CSIC (Spain)

48

Chromatin remodeling in plant development

Jarillo, José A.; Piñeiro, Manuel; Cubas, Pilar; Martínez-Zapater, José M.
2009-01-14

Digital.CSIC (Spain)

49

Chromatin assembly controls replication fork stability

Clemente-Ruiz, Marta; Prado, Félix
2009-05-22

Digital.CSIC (Spain)

50

Cell-cycle-dependent translation of histone mRNAs is the key control point for regulation of histone biosynthesis in Leishmania infantum

Soto, Manuel; Iborra, Salvador; Quijada, Luis; Folgueira, Cristina; Alonso, Carlos; Requena, José M.

The cell-cycle-dependent expression of the four core histones (H2A, H2B, H3 and H4) has been studied in the protozoan parasite Leishmania infantum. For that purpose, the cell cycle was arrested by incubation of promastigotes with the DNA synthesis inhibitor hydroxyurea, which induced an accumulation...

DRIVER (Spanish)

51

Cell-cycle-dependent translation of histone mRNAs is the key control point for regulation of histone biosynthesis in Leishmania infantum

Soto, Manuel; Iborra, Salvador; Quijada, Luis; Folgueira Fernández, Cristina; Alonso, Carlos; Requena Rolanía, José María
2004-02-09

Digital.CSIC (Spain)

52

CTCF regulates the local epigenetic state of ribosomal DNA repeats

Nobelen, Suzanne van de; Rosa-Garrido, Manuel; Delgado, M. Dolores; Galjart, Niels; Sleutels, Frank
2010-11-08

Digital.CSIC (Spain)

54

Arabidopsis ORC1 is a PHD-containing H3K4me3 effector that regulates transcription

Sánchez, María de la Paz; Gutiérrez Armenta, Crisanto
2009-01-26

Digital.CSIC (Spain)

55

Alternative mechanisms of transcriptional activation by Rap1p

Idrissi, Fátima-Zahra; García-Reyero, Natàlia; Fernández-Larrea, Juan B.; Piña, Benjamín
2001-05-17

Digital.CSIC (Spain)

56

Adipose tissue mass is modulated by SLUG (SNAI2).

Pérez-Mancera, P. A.; Bermejo-Rodríguez, C.; González-Herrero, I.; Flores, T.; Jiménez, R.; Sánchez-García, I.
2007-01-01

Digital.CSIC (Spain)

57

Accumulation of cell wall hydroxyproline-rich glycoprotein mRNA is an early event in maize embryo cell differentiation

Ruiz Ávila, Luis; Burgess, Shirley R.; Stiefel, Virginia; Ludevid, M. Dolors; Puigdomènech, Pere
1992-03-01

Digital.CSIC (Spain)

59

Zoroddu, Maria Antonietta; Peana, Massimiliano Francesco; Medici, Serenella

DRIVER (Spanish)