Sample records for ESTUDIOS DINAMICOS DE FUNCION (dynamic function studies)
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1

Electrocardiografía dinámica (holter): Estudio retrospectivo/ Dynamic electrocardiography (holter): A retrospective study

Ditollo, B.; Rotondaro, M.; Barrios, J.; Casalonga, O.; Bartolomeo, M.; Cattáneo, M. L.; Lightowler, C.
2006-12-01

Resumen en español Los autores presentan los resultados retrospectivos de la comparación de los diagnósticos obtenidos por medio del electrocardiograma convencional y la electrocardiografía dinámica de 143 pacientes caninos afectados por distintos padecimientos cardiovasculares. Seis de dichos casos fueron utilizados sólo para verificar el resultado de la terapéutica. De la comparación de 137 casos, se observó que la coincidencia entre los resultados del electrocardiograma convencio (mas) nal y el diagnostico obtenido con la electrocardiografía dinámica fue de sólo el 26,54% (32 casos contra 105). Si los resultados se analizan en función de los diagnósticos originales se observó que de los 61 electrocardiogramas convencionales considerados normales sólo 12 (19,4%) estudios dinámicos coincidieron con el diagnóstico previo, mientras que los restantes 49 (79,03%) demostraron la presencia de alguna forma de arritmia cardíaca y que de los 75 electrocardiogramas convencionales que mostraron la presencia de arritmias, veinte (26,67%) arrojaron un diagnóstico coincidente mientras que los restantes estudios dinámicos (55 - 73,33%) presentaron diagnósticos distintos, sea por la frecuencia o el tipo de arritmia encontrada. Sobre la base de los datos presentados aquí, se puede concluir que la electrocardiografía dinámica o ambulatoria, conocida coloquialmente como «Holter cardíaco» es una técnica altamente confiable y estrictamente necesaria para obtener diagnósticos adecuados y pronósticos más ajustados a la realidad de cada paciente en vista de las disparidades encontradas respecto de los diagnóstico obtenidos por medio del electrocardiograma convencional y la técnica dinámica. Resumen en inglés The authors present the results of a retrospective comparison between the conventional electrocardiogram and the dynamic electrocardiogram (Holter) diagnoses of 143 dogs affected by different cardiovascular diseases. In six cases the comparison was utilized to verify the result of the therapeutic measures. The coincidence between the diagnosis obtained with the conventional electrocardiogram and dynamic electrocardiography of 137 cases was of 26, 54% (32 cases against 105 (mas) ). If the results are analyzed in function of the original diagnosis, of the 61 conventional electrocardiograms considered normal only 12 (19,4%) coincided with the diagnosis of the dynamic studies, while the remains 49 (79,03%) showed the presence of some cardiac arrhythmia. Of the 75 conventional electrocardiograms that showed the presence of arrhythmias, 20 (26,67%) have a similar diagnosis, while the remains dynamic studies (55 - 73,33%) presented different diagnoses. On the basis of the data presented can be concluded that the ambulatory electrocardiograph or «cardiac Holter» is a strictly necessary and highly dependable technique to obtain adequate diagnoses and more adjusted prognostics to the reality of each patient in view of the disparities found regarding the diagnosis obtained through the conventional electrocardiogram and the dynamic technique.

Scientific Electronic Library Online (Spanish)

2

Asociación molecular y función del agente tensioactivo pulmonar de ternera/ Molecular association and function of calf lung surfactant

Martínez Montaño, María del Lurdez Consuelo; Muñoz Sánchez, José Luis; Baeza Ramírez, Isabel
2007-06-01

Resumen en español El agente tensioactivo pulmonar es un material compuesto de fosfolípidos, lípidos neutros y proteínas que se encuentra en la superficie alveolar de los pulmones y facilita la ventilación alveolar. La organización molecular de los componentes del agente tensioactivo aislado de pulmones de ternera fue analizada por calorimetría diferencial de barrido y por dispersión dinámica de luz y posteriormente comparada con los componentes organizados en liposomas uni y multil (mas) amelares; además, se probó la actividad de superficie al desarrollar en cobayos el síndrome de dificultad respiratoria. Los estudios de calorimetría mostraron que las interacciones lípido-proteína fueron considerablemente abatidas en el agente tensioactivo nativo, en comparación con las del agente tensioactivo en forma de liposomas uni o multilamelares. Los experimentos de dispersión dinámica de luz indicaron que el agente tensioactivo nativo tiene forma fibrilar con interacciones limitadas entre lípidos y proteínas, lo que sugiere que se encuentra organizado en una estructura en forma de reja formando una película de estructura estable. Los resultados obtenidos resaltan la importancia de la organización molecular del agente tensioactivo. Cuando éste fue usado para tratar a los animales con síndrome de dificultad respiratoria, los valores del pH arterial y de PaCO2 mejoraron casi hasta alcanzar los valores normales; cuando se utilizó el agente tensioactivo reconstituído como liposomas uni o multilamelares, los animales no se recuperaron. Es importante enfatizar que el método seguido en el protocolo de aislamiento del agente tensioactivo pulmonar de ternera permitió obtenerlo en una forma fisiológicamente activa. Resumen en inglés Surfactant, a highly surface-active material composed of phospholipids, neutral lipids and proteins, lines the lungs' alveolar surface facilitating alveolar ventilation. The molecular organization of surfactant components isolated from calf-lungs was analyzed by differential-scanning calorimetry and dynamic light-scattering, and subsequently compared to surfactant components organized in uni and multilamellar liposomes. The respiratory distress syndrome developed in adult (mas) guinea pigs was used for assessing surfactant activity. Calorimetry studies showed that lipid-protein interactions were considerably abated in native surfactant as compared to those of surfactant in uni or multi-lamellar liposomes. Light-scattering experiments indicated that native surfactant has a fibrillar shape with limited lipid-protein interactions, suggesting that it is organized in a lattice-like structure forming a stable film. These findings underscore the importance of the native molecular organization of surfactant. When surfactant reconstituted as uni- or multilamellar liposomes was administred to animals under respiratory distress, they did not recover. In contrast, when native surfactant was used to treat sick animals, arterial pH and PaCO2 values improved, almost reaching normal values. It is important to emphasize that fewer steps in the protocol for isolation of calf lung surfactant made it possible to obtain it in a physiologically active molecular form.

Scientific Electronic Library Online (Spanish)

3

Efecto de la maniobra inspiratoria y de la hiperinsuflación pulmonar en los flujos espiratorios máximos en pacientes con fibrosis quística/ EFFECT OF INSPIRATORY MANEUVER AND LUNG HYPERINFLATION ON MAXIMAL EXPIRATORY FLOW-VOLUME CURVES IN CYSTIC FIBROSIS PATIENTS

SÁNCHEZ D, IGNACIO; SIMONETTI, MARTA; DE KOSTER, JAN; CHERNICK, VÍCTOR
2003-01-01

Resumen en español El tiempo inspiratorio previo a la realización de una maniobra espiratoria forzada máxima (FEM) es una variable que no ha sido completamente estudiada en Fibrosis Quística (FQ). El objetivo de este estudio fue evaluar la hipótesis que niños con FQ tendrían mayores volúmenes y flujos espiratorios forzados al disminuir la duración del tiempo inspiratorio. Se estudiaron 16 niños con FQ, en etapa estable, sin haber presentado una exacerbación respiratoria en los úl (mas) timos dos meses, (10 hombres), de edad 11,9 ± 0,7 años (promedio ± ES), con un FEV1 de 62,8 ± 6,4% predicho. Las pruebas de función pulmonar consistieron en la medición de volúmenes pulmonares estáticos y resistencia de la vía aérea, seguido de evaluación dinámica de la función pulmonar. Esta última medición fue precedida de 3 maniobras inspiratorias diferentes en forma aleatoria [inspiración y detención de 0 segundos (M0), 2 segundos (M2) o 5 segundos (M5)]. El grupo se dividió en pacientes con hiperinsuflación pulmonar detectada por VR/CPT > 30%, (n = 9) y sin hiperinsuflación pulmonar RV/CPT Resumen en inglés The time course of the inspiration preceding the maximal forced expiratory maneuver (MFEM) has not been studied in cystic fibrosis (CF). We tested the hypothesis that CF children would have significantly higher forced expiratory volumes (FVC) and flows with decreasing duration of the inspiratory breathhold. We studied 16 stable CF patients (10 males) with no pulmonary exacerbation 2 months prior to the study, aged 11.9 ± 0.7 years (mean ± SEM) with a FEV1 of 62.8 ± 6.4 (mas) % predicted. Pulmonary function tests included static lung volume and airway resistance measurements, followed by dynamic lung function measurements. The latter were preceded by 3 different inspiratory maneuvers in a random order [breathhold of 0 (M0), 2 (M2) or 5 seconds (M5)]. Patients were divided by the presence of lung hyperinflation (RV/TLC > 30%), with 9 children with hyperinflation and 7 no-hyperinflated patients. We found that, in the hyperinflated CF patients (RV/TLC > 30%), FEV1 and FVC were 8.9 ± 3.4% (p

Scientific Electronic Library Online (Spanish)

4

Wormlike micelles in mixed surfactant systems: effect of cosolvents

Varade, Dharmesh; Rodríguez-Abreu, Carlos; Shrestha, Lok Kumar; Aramaki, Kenji
2007-08-16

Digital.CSIC (Spain)

7

Toward a realistic density functional theory potential energy surface for the H5+ cluster

Barragán, Patricia; Prosmiti, Rita; Roncero, Octavio; Aguado, Alfredo; Villarreal, Pablo; Delgado Barrio, Gerardo
2010-08-02

Digital.CSIC (Spain)

9

The role of exchange-correlation functionals in the potential energy surface and dynamics of N2 dissociation on W surfaces

Bocan, Gisela A.; Díez Muiño, Ricardo; Alducin Ochoa, Maite; Busnengo, Heriberto Fabio; Salin, Antoine
2008-04-16

Digital.CSIC (Spain)

11

The origin of public research organisation patents: an economic approach

Romero de Pablos, Ana; Azagra Caro, Joaquín; Plaza Gómez, Luis Manuel
2007-12-01

Digital.CSIC (Spain)

13

Synchronization between populations of neurons

Mirasso, Claudio R.; Gollo, Leonardo L.
2008-09-22

Digital.CSIC (Spain)

14

Surface mixing and biological activity in the four Eastern Boundary Upwelling Systems

Rossi, Vincent; López, Cristóbal; Hernández-García, Emilio; Sudre, Joel; Garçon, Véronique; Morel, Y.
2009-08-27

Digital.CSIC (Spain)

15

Study and formation of vesicle systems with low polydispersity index by ultrasound method

Pereira-Lachataignerais, J.; Pons Pons, Ramón; Panizza, P; Courbin, L; Rouch, J; López Serrano, Olga
2006-04-01

Digital.CSIC (Spain)

16

Structural and Functional Model for Ionic (K+/Na+) and pH Dependence of GTPase Activity and Polymerization of FtsZ, the Prokaryotic Ortholog of Tubulin

Mendieta, Jesús; Rico, Ana Isabel; López-Viñas, Eduardo; Vicente, Miguel; Mignorance, Jesús; Gómez-Puertas, Paulino
2009-07-03

Digital.CSIC (Spain)

17

Strange and charm mesons at FAIR

Oset, Eulogi; Nieves, Juan Miguel; Molina, Raquel; Gamermann, Daniel; Tolós, Laura; Cabrera, D.; García-Recio, R.; Ramos, A.
2010-02-01

Digital.CSIC (Spain)

19

Spin-label EPR study in thylakoid membranes from a new herbicide-resistant D1 mutant from soybean cell cultures deficient in fatty acid desaturation.

Yruela Guerrero, Inmaculada; Alfonso Lozano, Miguel; García-Rubio, Inés; Martínez Martínez, Jesús I.; Picorel Castaño, Rafael; Alonso Gascón, Pablo J.
2001-11-01

Digital.CSIC (Spain)

20

Spatial structure of deciduous forest stands with contrasting human influence in northwest Spain

Rozas Ortiz, Vicente Fernando; Zas Arregui, Rafael; Solla, Alejandro
2009-05-01

Digital.CSIC (Spain)

21

Simple genomes, complex interactions: Epistasis in RNA virus

Elena, Santiago F.; Solé, Ricard V.; Sardayés, Josep
2010-01-01

Digital.CSIC (Spain)

24

Scale-free topologies and activatory-inhibitory interactions

Gómez-Gardeñes, Jesús; Moreno, Yamir; Floría, Luis Mario
2006-03-01

Digital.CSIC (Spain)

25

SMC proteins, new players in the maintenance of genomic stability

Cortés-Ledesma, Felipe; Piccoli, Giaccomo de; Haber, James E.; Aragón, Luis; Aguilera, Andrés
2007-04-15

Digital.CSIC (Spain)

27

Resistance of virus to extinction on bottleneck passages: Study of a decaying and fluctuating pattern of fitness loss

Lázaro, Ester; Escarmis Homs, Cristina; Pérez Mercader, Juan; Manrubia, Susanna C.; Domingo, Esteban
2003-09-01

Digital.CSIC (Spain)

28
29

Quantum Gowdy T3 model: Schrödinger representation with unitary dynamics

Corichi, Alejandro; Cortez, Jerónimo; Mena Marugán, Guillermo A.; Velhinho, José M.
2007-12-27

Digital.CSIC (Spain)

30

Quantum Einstein–Rosen waves: coherent states and n-point functions

Barbero González, Jesús Fernando; Garay Elizondo, Iñaki; Villaseñor, Eduardo J. S.
2008-09-30

Digital.CSIC (Spain)

31

Quadratic discrete dynamics associated to quadratic maps in the plane

Durán Díaz, Raúl; Hernández Encinas, Luis; Muñoz Masqué, Jaime
2009-01-01

Digital.CSIC (Spain)

33

Properties of D and D-* mesons in the nuclear medium

Nieves, Juan Miguel; García-Recio, C.; Tolós, Laura
2009-12-04

Digital.CSIC (Spain)

34

Production of chromophoric dissolved organic matter by marine phytoplankton

Romera-Castillo, Cristina; Sarmento, Hugo; Álvarez-Salgado, Xosé Antón; Gasol, Josep M.; Marrasé, Cèlia
2010-01-01

Digital.CSIC (Spain)

35

Producción y consumo

Briz i Godino, Iván
2002-01-01

Digital.CSIC (Spain)

36

Pitch perception: A dynamical-systems perspective

Cartwright, Julyan H. E.; González, Diego L.; Piro, Oreste
2001-04-24

Digital.CSIC (Spain)

37

Pinch technique for Schwinger-Dyson equations

Binosi, D.; Papavassiliou, Joannis
2007-03-12

Digital.CSIC (Spain)

39

Physical oceanography of the Western Iberia ecosystem: Latest views and challenges

Relvas, Paulo; Barton, Eric D.; Dubert, Jesús; Oliveira, Paulo B.; Peliz, Álvaro; Da Silva, J. C. B.; Santos, A. Miguel P.
2007-05-17

Digital.CSIC (Spain)

40

Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family

Couceiro, José R.; Martín-Bermudo, María D.; Bustelo, Xosé R.
2005-08-15

Digital.CSIC (Spain)

42

Operating regimes of GaAs-AlGaAs semiconductor ring lasers: experiment and model

Sorel, Marc; Giuliani, Guido; Scirè, Alessandro; Miglierina, Riccardo; Laybourn, P. J. R.; Donati, Silvano
2003-10-01

Digital.CSIC (Spain)

44

Nonperturbative gluon and ghost propagators for d=3 Yang-Mills theory

Papavassiliou, Joannis; Aguilar, A. C.; Binosi, D.
2010-06-25

Digital.CSIC (Spain)

45

Nonperturbative comparison of QCD effective charges

Aguilar, A. C.; Binosi, D.; Papavassiliou, Joannis; Rodriguez-Quintero, J.
2009-10-15

Digital.CSIC (Spain)

46
48
51

Multispectral classification of grass weeds and wheat (Triticum durum) using linear and nonparametric functional discriminant analysis and neural networks

López-Granados, Francisca; Peña-Barragán, José Manuel; Jurado-Expósito, Montserrat; Francisco-Fernández, M.; Cao, R.; Alonso-Betanzos, A.; Fontela-Romero, O.
2008-02-01

Digital.CSIC (Spain)

52

Modelling biochemical processes in orchards at leaf- and canopy-level using hyperspectral data

Delalieux, S.; Kempeneers, P.; Aardt, J. A. N. van; Backer, S. de; Zarco-Tejada, Pablo J.; Sepulcre-Cantó, Guadalupe; Sagardoy, R.; Morales Iribas, Fermín; Scheunders, P.; Coppin, P.
2006-01-01

Digital.CSIC (Spain)

53

Modelling approaches for MPC of large-scale sewage systems

Ocampo Martínez, Carlos A.; Puig Cayuela, Vicenç
2009-01-01

Digital.CSIC (Spain)

55

MHC Adaptive Divergence between Closely Related and Sympatric African Cichlids

Blais, Jonatan; Rico, Ciro; Van Oosterhout, Cock; Cable, Joanne; Turner, George F.; Bernatchez, Louis
2007-08-15

Digital.CSIC (Spain)

56

Long-term impact of acid resin waste deposits on soil quality of forest areas II. Biological indicators.

Pérez de Mora, Alfredo; Madejón, Engracia; Cabrera, Francisco; Buegger, Franz; Fuß, Roland; Pritsch, Karin; Schloter, Michael
2008-01-01

Digital.CSIC (Spain)

57

Large-scale emergent properties of an autocatalytic reaction-diffusion model subject to noise

Hochberg, David; Lesmes, Felipe; Morán, Federico; Pérez-Mercader, Juan
2003-12-24

Digital.CSIC (Spain)

59

Initial growth of Boltzmann entropy and chaos in a large assembly of weakly interacting systems

Falcioni, Massimo; Palatella, Luigi; Pigolotti, Simone; Rondoni, Lamberto; Vulpiani, Angelo
2007-11-01

Digital.CSIC (Spain)

60

Inherent noise can facilitate coherence in collective swarm motion

Yates, Christian A.; Erban, Radek; Escudero, Carlos; Couzin, Iain D.; Buhl, Jerome; Kevrekidis, Ioannis G.; Mainia, Philip K.; Sumpter, David J. T.
2009-03-30

Digital.CSIC (Spain)

62

Indirect determination of the Kugo-Ojima function from lattice data

Aguilar, A. C.; Binosi, D.; Papavassiliou, Joannis
2009-11-01

Digital.CSIC (Spain)

65

Hidronefrosis del recién nacido: Cintigrafía renal dinámica con Tc99m MAG3 durante el primer mes de vida/ Dynamic renal scintigraphy with Tc99m MAG3 for the diagnosis of newborn hydronephrosis

Orellana B, Pilar; Baquedano D, Paulina; Cavagnaro SM, Felipe; Lagomarsino F, Edda; García B, Cristián; Carreño P, Juan Eduardo; Meneses Q, Luis
2003-03-01

Resumen en inglés Background: The early and accurate diagnosis of obstructive uropathy in the newborn, prevents secondary complications and kidney damage. Aim: To study the usefulness of Tc99M MAG3 diuretic renogram in newborns with hydronephrosis. Material and methods: Forty newborns, aged 1 to 30 days, with hydronephrosis, were studied. A Tc99M MAG3 diuretic renogram (DR) was done and its results were compared with clinical features and other imaging studies. Each kidney and its ureter, (mas) were considered a renal unit. Results: Seventy six renal units were evaluated. Twenty six were normal on prenatal ultrasound examination and DR. In 11 of the 50 renal units with hydronephrosis, renal function was impaired. Thus, it was impossible to obtain an excretory curve. In 17 of the 39 remaining renal units, the absence of obstructive uropathy was demonstrated clinically. In 16 of these, the DR showed absence of obstruction. In 20 of 21 renal units with confirmed obstructive uropathy, DR showed an obstructive pattern. Conclusions: In newborns, there is an adequate Tc99M MAG3 uptake and diuretic response. Thus, DR becomes a good functional assessment method in newborns with hydronephrosis (Rev Méd Chile 2003; 131: 251-8)

Scientific Electronic Library Online (Spanish)

67

Functional, fractal nonlinear response with application to rate processes with memory, allometry, and population genetics

Vlad, Marcel O.; Morán, Federico; Popa, Vlad T.; Szedlacsek, Stefan E.; Ross, John
2007-03-14

Digital.CSIC (Spain)

69

Factors controlling planktonic size spectral responses to autumnal circulation in a Mediterranean lake

Álvarez Cobelas, Miguel; Rojo, Carmen; Velasco, José Luis; Baltanás, Ángel
2006-01-01

Digital.CSIC (Spain)

70

F+OH reactive collisions on new excited 3A'' and 3A' potential-energy surfaces

Gómez Carrasco, Susana; Roncero, Octavio; González-Sánchez, Lola; Hernández, M. Luz; Alvariño, José M.; Paniagua, Miguel; Aguado, Alfredo
2005-09-22

Digital.CSIC (Spain)

71

Entanglement dynamics in presence of diversity under decohering environments

Galve, Fernando; Giorgi, Gian Luca; Zambrini, Roberta
2010-02-01

Digital.CSIC (Spain)

74

Dynamics, correlation and synchronization behavior in rings of delay-coupled oscillators

Van der Sande, Guy; Soriano, Miguel C.; Fischer, Ingo; Mirasso, Claudio R.
2008-05-13

Digital.CSIC (Spain)

75
76

Dynamics at an elongated, intermediate depth seamount in the North Atlantic (Sedlo Seamount, 40°20′N, 26°40′W)

Mohn, Christian; White, Martin; Bashmachnikov, Igor; Jose, Felix; Pelegrí, Josep Lluís
2009-12-01

Digital.CSIC (Spain)

77

Dynamics and Synchronization in Neuronal Models

Mirasso Santos, Claudio R.; Pérez, Toni
2009-07-01

Digital.CSIC (Spain)

78

Dynamical entrainment of unidirectionally coupled single mode diode lasers

Pérez, Toni; Vicente, Raúl; Mirasso, Claudio R.; Colet, Pere
2002-01-16

Digital.CSIC (Spain)

79

Dynamical aspects of generalized Palatini theories of gravity

Sanchis-Alepuz, Hélios; Tripathi, S.; Olmo, Gonzalo J.
2009-07-14

Digital.CSIC (Spain)

80

Duloxetina y otros antidepresivos tricíclicos: efectos farmacodinámicos en el tracto urinario inferior/ Duloxetine and others tricyclic antidepressants: pharmacodynamic effects on lower urinary tract

Vela Navarrete, R.; Pérez Martínez, F.C.; Cabrera Pérez, J.; Ramírez Pérez del Yerro, M.; González Enguita, C.
2003-12-01

Resumen en español INTRODUCCIÓN: Durante años la farmacología de la dinámica miccional ha estado presidida por el protagonismo del sistema nervioso autónomo y sus componentes simpático y parasimpático. Recientes investigaciones advierten de una mayor complejidad de la dinámica miccional, atribuyendo un papel más relevante al sistema nervioso central (SNC), al esfínter estriado y al arco aferente, ofreciendo nuevas opciones farmacológicas entre las que hay que destacar a los Antid (mas) epresivos Tricíclicos (A.T.), motivo de esta revisión de conjunto. MATERIAL Y MÉTODOS: A partir del trabajo de la Primera Consulta sobre Incontinencia (Montecarlo, 1999), se han revisado las publicaciones anteriores y posteriores sobre los A.T. tanto experimentales (estudios isométricos e "in vivo") como clínicas, indagando sobre evidencias farmacológicas, mecanismo de acción, tolerancia y otros efectos. RESULTADOS: Sólo un grupo reducido de A.T. ha sido sometido a estudios urodinámicos y empleados en clínica. Los recientes trabajos sobre Duloxetina han despertado un interés especial por su potencial farmacológico. Simultáneamente se ha producido un cambio notable en la interpretación fisiológica de la dinámica miccional de singular trascendencia. CONCLUSIONES: Nuevos conocimientos sobre el control periférico y central de la dinámica continencia-micción ofrecen respaldo a innovadoras estrategias farmacológicas entre las que destacan los A.T., cuya eficacia y tolerancia es revisada. Resumen en inglés INTRODUCTION: During years the pharmacology of the lower urinary tract function has been presided by the protagonism of the autonomic nervous system and its components, simpathetic and parasimpathetic. Recent investigations proved a greater complexity of mictional dynamics, attributing a more important role to the central nervous system (SNC), to the striated sphincter and to the afferent arc, offering a new opportunity to the Tricyclic Antidepressants (T.A.), reason for (mas) this general review. MATERIAL AND METHODS: Using as reference the work of the First Consultation on Incontinence (Montecarlo, 1999), the previous and later publications about T.A. have been reviewed, including experimental (isometric and "in vivo" studies) and clinical studies, investigating on pharmacological evidences, mechanism of action, tolerance and other effects of T.A. RESULTS: Only a reduced group of T.A. have been submitted to experimental evaluations and employeed in clinical trials. The recent works on Duloxetine have waked up a special interest by their pharmacological potential. CONCLUSIONS: New knowledge on the peripheral and central control of the continence-miction dynamic offer new pathways for the treatment with T.A., whose effectiveness and tolerance are reviewed.

Scientific Electronic Library Online (Spanish)

82

Dopaminergic deficiency in mice with reduced levels of the dual-specificity tyrosine-phosphorylated and regulated kinase 1A, Dyrk1A+/-

Martinez de Lagran, M.; Bortolozzi, Analía; Millan, O.; Gispert, J.D.; Gonzalez, J.R.; Arbones, M.L.; Artigas, Francesc; Dierssen, M.
2007-08-01

Digital.CSIC (Spain)

83

Direct versus resonances mediated F+OH collisions on a new 3A'' potential energy surface

Gómez Carrasco, Susana; González-Sánchez, Lola; Aguado, Alfredo; Roncero, Octavio; Alvariño, José M.; Hernández, M. Luz; Paniagua, Miguel
2004-09-08

Digital.CSIC (Spain)

84

Dinoflagellate cyst assemblages as repertoire of species diversity: main results of the EU-Seed Project related to Mediterranean sites

Garcés, Esther; Satta, Cecilia Teodora; Anglès, Silvia; Lugliè, Antonella; Rubino, F.; Giacobbe, Maria Grazia; Penna, Antonella
2010-01-01

Digital.CSIC (Spain)

85

Diffusion in Fluctuating Media: Resonant Activation

Revelli, Jorge A.; Budde, Carlos E.; Wio, Horacio S.
2004-05-11

Digital.CSIC (Spain)

86

Differentiating plant cells switched to proliferation remodel the functional organization of nuclear domains

Sánchez-Testillano, Pilar; González-Melendi, Pablo; Coronado, María José; Seguí-Simarro, José M.; Moreno, Miguel A.; Risueño, María del Carmen
2005-01-01

Digital.CSIC (Spain)

87

Dielectric properties of Pb0.5Ca0.5TiO3 thin films

Mendiola, J.; Jiménez, R.; Ramos, P.; Alemany, C.; Bretos, I.; Calzada Coco, María Lourdes
2005-07-01

Digital.CSIC (Spain)

89
95

Children's Gestures from 18 to 30 months

Andrén, Mats

This thesis concerns the nature of the gestures performed by five Swedish children. The children are followed from 18 to 30 months of age: an age range which is characterized by a rapid succession of developmental changes in children's abilities to communicate by means of both spoken language and ge...

DRIVER (Spanish)

96

Charmed hadrons in nuclear medium

Nieves, Juan Miguel; García-Recio, C.; Ramos, A.; Tolós, Laura; Oset, Eulogi; Molina, Raquel; Gamermann, Daniel
2010-09-01

Digital.CSIC (Spain)

97

Characterizing population growth rate of Convolvulus arvensis in wheat–sunflower no-tillage systems

Jurado-Expósito, Montserrat; López-Granados, Francisca; González-Andújar, José Luis; García-Torres, Luis
2005-09-01

Digital.CSIC (Spain)

98

Biological control of harmful algal blooms: A modelling study

Solé, Jordi; Estrada, Marta; Garcia-Ladona, Emilio
2006-07-01

Digital.CSIC (Spain)

100

A path-integral Monte Carlo study of a small cluster: The Ar trimer

Pérez de Tudela, Ricardo; Márquez-Mijares, Maykel; González Lezana, Tomás; Roncero, Octavio; Miret-Artés, Salvador; Delgado Barrio, Gerardo; Villareal, Pablo
2010-06-23

Digital.CSIC (Spain)

101

A neuro-fuzzy model for nonlinear plants identification

Baruch, Ieroham Solomon; Gortcheva, Elena A.; Thomas Arroyo, Federico; Garrido-Moctezuma, Rubén Alejandro
1999-01-01

Digital.CSIC (Spain)

103

A detailed quantum mechanical and quasiclassical trajectory study on the dynamics of the H(+) + H2 --> H2 + H(+) exchange reaction

González Lezana, Tomás; Roncero, Octavio; Honvault, Pascal; Launay, Jean-Michel; Bulut, Niyazi; Aoiz, F. Javier; Bañares, Luis
2006-09-06

Digital.CSIC (Spain)

105

La oclusión como factor etiopatológico en los trastornos temporomandibulares/ The occlusion as an etiopathological risk factor in temporomandibular disturbance

García-Fajardo Palacios, Carlos; Cacho Casado, Alberto; Fonte Trigo, Abelardo; Pérez -Varela, Juan Carlos
2007-06-01

Resumen en español Fundamento. La relación intrínseca entre alteración oclusal y trastorno articular no es un paradigma que se cumpla siempre. Sin embargo, el análisis oclusal debe ser siempre un requisito imprescindible en la exploración del paciente disfuncional ya que multitud de estudios demuestran que puede representar un factor etiológico de primer orden. Material y método. A través de distintas revisiones bibliográficas se describen los principales estados oclusales y se int (mas) enta establecer una posible relación estructural y funcional entre los distintos cuadros articulares. Resultados. La relación entre cada tipo de maloclusión y un determinado trastorno temporomandibular (TTM), se evidencia a través de las distintas posiciones condilares en la cavidad glenoidea. Se podría hablar de una Unidad Diente-Cóndilo ya que el aparato estomatognático posee un singular bloque óseo, como es la mandíbula, que alberga en su misma estructura a dientes y cóndilo, lo que implicaría que las distintas variantes de la oclusión se trasladen de manera dinámica a la articulación. Conclusión. Aunque la implicación del factor oclusal en la etiopatología temporomandibular está condicionada por la presencia de otros factores coadyudantes, el reestablecimiento de la oclusión fisiológica puede ser primordial para reestablecer la homeostasis articular e implicaría conocer la biomecánica particular de cada paciente y su correlación con sus parámetros biológicos. Resumen en inglés Background: The relationship between occlusal discrepancies and TMJ disorders does not always hold true. Nonetheless, occlusal analysis is a requisite to achieve a correct diagnosis in the dysfunctional patient. Many studies show that occlusal discrepancies can be a very important etiological factor. Material and Methods: Various literature reviews describe the main occlusal types and the possibility of structural and functional relationships with TMJ derangements. Result (mas) s: The relationship between each kind of malocclusion and a specific TMJ disorder is due to different condyle positions in the glenoid fossa. It may be appropriate to introduce the term Tooth-Condyle Unit because the stomatognathic system has a specific bone block or mandible, which encompass teeth and condyles. The various occlusal schemes can be considered dynamic which influences the joint. Conclusion: The involvement of occlusion in the etiology of TMJ disorder is conditioned by the presence of other factors. However, physiologic occlusion must be re-established for correct joint function. This implies that the specific biomechanics of each patient and it's correlation with biological parameters must be known in order to provide joint homeostasis.

Scientific Electronic Library Online (Spanish)

106

La epigenética y los estudios en gemelos en el campo de la psiquiatría/ Epigenetics and twin studies in psychiatric domains

González Ramírez, Adriana Estrella; Díaz Martínez, Alejandro; Díaz-Anzaldúa, Adriana
2008-06-01

Resumen en español La secuencia de ADN genómico que caracteriza a nuestra especie constituye la piedra fundamental de la vida humana; parte de ella se refleja en la secuencia del ARN y a través de éste se dicta la información necesaria para que nuestras células produzcan proteínas. La genética contribuye de manera importante a los avances en el campo médico. Los descubrimientos genéticos han permitido desarrollar estrategias para modificar, prevenir y proponer nuevas terapias para (mas) diversas enfermedades. En el siglo XIX, Gregor Johann Mendel desarrolló un modelo teórico capaz de predecir la naturaleza y propiedades de los mecanismos de la herencia, que sigue siendo indispensable para explicar la base de la herencia humana. Otro suceso determinante en la historia de la Medicina se dio a conocer casi nueve décadas después cuando James Watson y Francis Crick describieron su modelo estructural para el ADN. Posteriormente se introdujeron la clonación posicional y la reacción en cadena de la polimerasa; más recientemente se publicó cerca del 99% de la secuencia del genoma humano. El período actual se conoce como la era post-genómica, ya que además de descifrar genomas completos, los investigadores pretenden, entre otras cosas, esclarecer los mecanismos que influyen en la activación e inactivación de los genes, lo cual en parte involucra un nivel epigenético. En las ciencias médicas los gemelos constituyen un grupo idóneo para abordar el estudio de las enfermedades hereditarias. En este tipo de padecimientos suelen observarse similitudes entre parientes, en especial si se trata de gemelos monocigóticos. Sin embargo, aun en este tipo de hermanos se detectan diferencias importantes. Parámetros como los grados de concordancia y porcentajes de heredabilidad han puesto de manifiesto que un gemelo monocigótico puede presentar trastornos hereditarios que su co-gemelo nunca tendrá. La epigenética es el estudio de los cambios en la función de los genes que no afectan la secuencia del ADN, por modificaciones que tienen lugar principalmente en las citosinas de éste y en las histonas de la cromatina. Se ha determinado que las modificaciones epigenéticas son mucho más frecuentes que aquellas que modifican la secuencia del ADN, por lo que constituyen uno de los fundamentos de la diversidad biológica, muestran la manera en que el ambiente puede modular la expresión genética y contribuyen así a nuestro fenotipo. Esta revisión reúne datos sobre la posible relevancia de la epigenética en el estudio de los trastornos mentales y como posible explicación parcial de las diferencias observadas entre gemelos >. Un conocimiento más profundo de los patrones epigenéticos podría contribuir a identificar factores de riesgo para estos trastornos. Resumen en inglés The sequence of the human genome integrates the keystone of our life. Part of it is transcribed to RNA, which in turn provides the information required by our cells to produce proteins. Discoveries in the genetics field have been essential to medicine and have been used to develop strategies to modify, prevent and propose new therapeutic approaches for human diseases. In the 19th Century, Gregor Johann Mendel developed a theoretical model which was able to predict in an a (mas) ccurate way hereditary mechanisms; indeed, his laws still explain the basis of human inheritance. Almost ninety years later, James Watson and Francis Crick announced their double-helix model of the DNA molecule. Then, positional cloning and the polymerase chain reaction (PCR) were introduced; more recently, almost 99% of the sequence of our genome was made public. The current period of time is known as the post-genomic era, due to the fact that researchers are not only obtaining the complete sequences of thousands of genomes, but are also searching for clues that may help understand the mechanisms that affect gene activation and deactivation, in which epigenetic factors are also involved. In medical domains, twins constitute a suitable group to study inherited disorders. Dizygotic or fraternal twins are produced by different egg and sperm cells, and even when these two fertilization events occur simultaneously, dizygotic twins share approximately the same percentage of genetic material than any pair of siblings, that is, around 50%. Some authors have suggested that the tendency for spontaneous dizygotic twinning could be attributed to a double ovulation which is genetically determined in an autosomal dominant manner. Monozygotic, as opposed to dizygotic twins, are produced by a single zygote whose cells are dissociated and originate two independent organisms; approximately a third of monozygotic twins are separated before the 5th day after fertilization, and the rest between the 5th and the 15th day. Most monozygotic twins are very similar; nevertheless, some few exceptions prove that in fact they actually do not have to be identical. Relatives of a person with a mental disorder tend to share traits associated with this disease, especially if the patient and the relative are monozygotic twins. However, important differences may be detected even between each pair of identical twins. Parameters such as concordance and heritability have shown that a monozygotic twin can develop an inherited disorder while his or her co-twin will always be disease-free. In addition to differences in susceptibility to inherited diseases, this kind of twins can display dissimilarities in somatic cell mutations (more overtly noticeable when ageing), their set of antibodies and T cell receptors, their number of mitochondrial DNA molecules, and chromosome X inactivation patterns in women, all of which are the main subject of many ongoing studies. A recent report shows that from 160 monozygotic twin pairs who were 3 to 74 years old, epigenetic patterns were identical early in life, but differences were more obvious at older ages, especially if twins were raised apart or if they had different medical history. Medical conditions, but also environmental factors such as pregnancy tobacco exposure, physical activity, and diet could contribute to differences in epigenetic patterns. It has been shown that epigenetic modifications (or epi-mutations) are more frequent than the ones that modify DNA sequence, so they are part of the fundamental causes of biological diversity, and they show how environment can modulate gene expression and contribute to our phenotype. Even when twin studies are sometimes considered purely genetic, they also give information about the influence of environmental factors. However, it is important to consider with caution the results from this type of studies. Heritability estimates are not unchangeable facts. They depend on the sample being analyzed, the genes involved in the specific sample, the characteristics of the environmental factors which members of this group were exposed to, and the precise moment the study was done. Epigenetics refers to changes that do not alter the DNA sequence but affect gene function due to chemical modifications which mainly occur in DNA cytosines and in chromatin-related histones. Epigenetic processes are covalent modifications which include the addition of functional groups (methyl, acetyl, phosphate, etc.) or proteins (ubiquitin, SUMO, etc.) to the DNA molecule or to associated proteins. These modifications contribute to the activation or inhibition of transcription, which leads to changes in messenger ARN expression that can ultimately influence the onset of disease. Pseudogenes are still being excluded while new genes are being confirmed in our genome sequence, but the current estimates indicate that each one of our nucleated cells contains almost 22000 genes (excluding mitochondrial DNA) which encode for polypeptides and more than 4,000 whose final product is RNA. Gene expression is partially controlled by DNA coiling around globular proteins called histones, which constitute a structure known as chromatin, a DNA-protein complex that represents the packaging of 3.25 billion base pairs of our genetic information. Physical and chemical chromatin modifications can also affect gene expression by changing DNA-protein interactions; in general terms, genes are inhibited when chromatin is packed and they are active when it is free. These dynamic states are controlled by epigenetic reversible modifications on DNA methylation or by changes in histones. It has been shown that subtle epigenetic differences between any two human beings are associated with dissimilar final chromatin remodeling, as well as expression/repression of genes.

Scientific Electronic Library Online (Spanish)