Sample records for FUNCION DELTA (delta function)
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1

Intervención nutricional en niños y adolescentes con fibrosis quística: Relación con la función pulmonar/ Nutritional intervention in children and adolescents with cystic fibrosis: Relationship with pulmonary function

Martínez-Costa, C.; Escribano, A.; Núñez Gómez, F.; García-Maset, L.; Luján, J.; Martínez-Rodríguez, L.
2005-06-01

Resumen en español Objetivo: Evaluar los efectos de la intervención nutricional precoz y continuada en pacientes pediátricos con fibrosis quística (FQ) y su posible implicación en la función pulmonar. Pacientes y métodos: Se incluyen el seguimiento de 19 pacientes con FQ (11 niñas, 8 niños) de 17 meses a 18 años de edad y promedio de 10 años de enfermedad. El genotipo de 16 pacientes es delta F 508 (10 homo, 6 heterocigotos). Cada 2-3 meses se les ha realizado: valoración clínic (mas) a, dietética y antropométrica clasificando el estado de nutrición (EN) según Z pesto/talla, % peso para la talla, índice de masa corporal y Z talla/edad. Coincidentemente se obtuvo cultivo de secreciones respiratorias y espirometría; y anualmente determinaciones bioquímicas, hematológicas y de heces. La intervención nutricional incluyó: recomendaciones dietéticas, nutrición enteral (NE) oral o invasiva y tratamiento farmacológico con ezimas pancreáticos, vitaminas liposolubles, minerales y oligoelementos. Resultados y comentarios: La mayoría experimentaron mejoría antropométrica resultando significativa para el peso, relaciónpeso/talla y pliegue tricipital (p Resumen en inglés Objective: To assess the effects of early and continuous nutritional intervention in pediatric patients with cystic fibrosis (CF) and its possible implication in pulmonary function. Patients and methods:Included is the follow-up of 19 patients with CF (11 female and 8 male children), from 17 months to 18 years of age, and a mean disease duration of 10 years. Genotype from 16 patients is delta F 508 (10 homozygotic, 6 heterozygotic). The following items have been performed (mas) every 2-3 months: clinical, dietary and anthropometrical assessment, classifying nutritional status (NS) by Z scores of weight/height, % of weight to height, body mass index, and Z scores of height/age. Concurrently, respiratory secretions culture and spiro-metry were obtained; and annually, biochemistry, hematologic and feces determinations. Nutritional intervention included: dietary recommendations, oral or invasive enteral nutrition (EN) and pharmacologic treatment with pancreatic enzymes, fat-soluble vitamins, minerals and oligoelements. Results and commentaries:Most of them experienced anthropometrical improvement being significant for weight, the relationship of weight/height and the tricipital fold (p

Scientific Electronic Library Online (Spanish)

2

Muerte súbita cardiaca: Las siete preguntas para las cuales todo cardiólogo debe tener respuesta/ Sudden cardiac death: the 7 questions all cardiologists must have an answer to

Garillo, Raúl
2010-09-01

Resumen en español El cardiodesfibrilador implantable ha revolucionado la prevención y el tratamiento de la muerte súbita cardiaca. A pesar de ello subsisten dudas en cuanto a su indicación en diversas circunstancias de la práctica clínica diaria. Algunas respuestas para los principales interrogantes se describen a continuación: 1. de acuerdo a las estadísticas mundiales la incidencia anual de muerte súbita varía entre 750 y 1000 muertes súbitas cardiacas por millón de habitantes (mas) , y el 80% se relacionan con cardiopatía isquémica. 2. Mientras aproximadamente un cuarto de las muertes súbitas ocurren en sujetos con antecedentes severos de enfermedad cardiaca y deterioro de la función ventricular, en el 75% restante el episodio se desarrolla en individuos con escasos antecedentes o sin ellos y con funciones ventriculares normales. 3. En sujetos con antecedentes previos, el riesgo de desarrollar arritmias letales no decrece con el paso del tiempo, y puede desarrollarse muchos años después del episodio que marcó el inicio de la enfermedad. 4. La Terapia farmacológica puede actuar como co-adyudante para disminuir el riesgo arrítmico, pero no reemplaza la indicación del cardiodesfibrilador de acuerdo a las guías actuales. 5. El estudio electrofisiológico, no ha demostrado ser eficaz en la estratificación del riesgo de muerte súbita cardiaca. 6. En individuos con escasos antecedentes y sin deterioro de la función ventricular, y en la población general que consulta al cardiólogo, los antecedentes familiares de muerte súbita a temprana edad, y la observación de patrones electrocardiográficos específicos (onda delta, QT largo, etc.), pueden ser las únicas alertas que nos lleven a investigar un posible candidato a la muerte súbita. 7. A pesar de la descripción de choques inapropiados y de eventualmente daño miocárdico asociado a la terapia de choque, el cardiodesfibrilador continúa siendo la terapia de elección en la prevención y tratamiento de la muerte súbita arrítmica. Resumen en inglés The implantable cardioverter defibrillator (ICD), has changed the view related to prevention and treatment of sudden cardiac arrest (SCA). However, some issues are still matter of discussion. Answers for the main questions are briefly exposed. 1. According to worldwide statistics, the annual incidence of SCA varies between 750 and 1000 people per million inhabitants. 2. Nearly 25% of SCA are related to individuals with severe heart disease and low ejection fraction, but i (mas) n the remaining 75% there are scarce or no antecedents at all, plus normal left ventricular function. 3. In subjects with history of severe heart disease, the risk of SCA does not decrease along the time. 4. Pharmacological treatment did not prove to be safe for SCA prevention and cannot replace the ICD indication. 5. Except in particular cases, EP testing is not the right tool for risk stratification of SCA. 6. In the population with minor or without antecedents of heart disease, family history of SCA below 40 years old, or some features in the ECG (delta wave, long QT interval, etc), would be the unique sign of risk for developing SCA. 7. Although inappropriate shocks and eventually myocardial injury due to shock therapy may occur, the ICD still is the best therapy for prevention and treatment of SCA.

Scientific Electronic Library Online (Spanish)

3

Valores funcionales respiratorios pre y post- operatorios en pacientes sometidos a resección pulmonar/ Preoperating and postoperating respiratory functional values in patients submissive of lung volume reduction surgery

Fernández García, Sergio; Valdés Díaz, Solangel; Oramas Delgado, Miguel; Fernández Fernández, Mireya; García Castañeda, Hilda
2010-06-01

Resumen en español Se realizó un estudio observacional, analítico, prospectivo, en el período 2006-2008, en el Hospital Neumológico Benéfico Jurídico, con el objetivo de comparar los valores predictivos espirométricos de los enfermos candidatos a resección pulmonar con los obtenidos después de la intervención quirúrgica. La muestra quedó formada por 28 pacientes, residentes en Ciudad de La Habana. Para comparar el valor predictivo del volumen espiratorio forzado en el primer seg (mas) undo con el valor real, seis meses después de la resección pulmonar se calculó el cociente delta relativo que expresó en porcentaje el grado de coincidencia entre estas dos variables. Una vez recogida la información se sometió a un análisis exploratorio de datos, con pruebas de significación asociadas. Los resultados mostraron que la espirometría clínica tiene un espacio indiscutible en la evaluación de la función pulmonar preoperatoria de los candidatos a resección pulmonar. Los valores predictivos y reales después de la resección pulmonar del volumen espiratorio forzado en el primer segundo fueron semejantes. La lobectomía superior izquierda fue el tipo de intervención quirúrgica con mayor similitud entre estos valores, por el contrario la neumectomía izquierda resultó ser la técnica con mayores diferencias entre los mismos. Resumen en inglés We carried out an observacional, analytical, prospective study in the period 2006-2008, at Neumologico Hospital Benéfico Jurídico, with the objective to compare the spirometry predicted values of the patients candidates to pulmonary surgery with the obtained ones after the operation. The sample was formed by 28 patients, residents in Havana City. In order to compare the predictive value of the forced expiratory volume in the first second with the real value six months a (mas) fter the pulmonary surgery, we calculated the quotient relative delta that expressed in percentage the degree of coincidence between these two variables. The information was put under an exploratory analysis of data, with associate tests of meaning. The results showed that the spirometry has an unquestionable space in the evaluation of the preoperating pulmonary function of the candidates to pulmonary surgery. The predictive and real values after the pulmonary surgery of the forced expiratory volume in the first second were similar. The left upper lobectomy was the type of operation with greater similarity between these values, on the contrary the left neumectomy turned out to be the technique with greater differences between such.

Scientific Electronic Library Online (Spanish)

4

La actividad Alfa frontal en insomnes primarios con dificultad para iniciar el sueño/ Frontal alpha activity in primary insomniacs with sleep onset difficulties

Figueredo-Rodríguez, Pedro; del Río-Portilla, Yolanda; Sánchez-Romero, Jorge Iván; Pérez-Ortiz, Alfonso; Corsi-Cabrera, María
2009-02-01

Resumen en español La dificultad para conciliar el sueño es uno de los síntomas más frecuentes del insomnio primario. La apreciación subjetiva de un periodo prolongado de latencia al sueño, aun en presencia de signos de sueño, puede deberse a la coexistencia de los mecanismos promotores de la vigilia y del sueño, y la lucha por el predominio de uno de ellos. La red de atención ejecutiva, conformada por las áreas de asociación frontales y parietales, cumple un papel de particular i (mas) mportancia en el control endógeno de la atención y en la regulación del alertamiento por parte de la corteza. Las frecuencias del EEG en el rango de actividad alfa lenta (7 y 8 Hz) participan en los procesos cognoscitivos activos de la vigilia, especialmente en la atención y la memoria, y son indicadoras del control corticofugo, o top-down, de estos procesos. Sin embargo, el análisis cuantitativo del EEG durante el proceso de conciliación del sueño en los insomnes se ha centrado fundamentalmente en la actividad delta, theta y beta, y únicamente en las regiones centrales (C3 y C4), de tal forma que el análisis de banda estrecha del EEG y su distribución en toda la corteza podría contribuir a una mejor comprensión de los mecanismos neurales comprometidos en la etiología del insomnio primario. El objetivo principal de esta investigación es, por lo tanto, analizar el espectro de frecuencias con resolución de 1 Hz en todas las derivaciones del Sistema Internacional 10-20 en insomnes primarios crónicos durante el periodo inicial del sueño (PIS) y comparar a estos últimos con un grupo control. Con el fin de aislar las características del EEG de los insomnes de causas circunstanciales, se analizará la primera noche de PSG igualando en ambos grupos el efecto activador que ejerce el medio circundante sobre el Sistema Nervioso Central, el estado psicológico y la arquitectura del sueño. Se estudiaron nueve pacientes insomnes primarios cuya queja principal era la dificultad para iniciar el sueño y nueve sujetos controles libres de problemas de sueño, diestros y entre 19-34 años de edad. Se realizó la PSG durante la primera noche en el laboratorio siguiendo los procedimientos estándar y adicionalmente se registraron las 19 derivaciones del Sistema Internacional 10-20. Se obtuvieron los espectros de potencia del EEG de todas las derivaciones con resolución de 1 Hz del PIS (tiempo comprendido entre las buenas noches y el sueño consolidado: 3 minutos consecutivos de sueño delta). Los insomnes tuvieron mayor actividad alfa lenta (7 y 8 Hz) en las regiones frontales durante la etapa 2 del PIS y de algunas frecuencias rápidas (beta y gamma) en la vigilia; subestimaron la calidad de sueño; y mostraron el mismo efecto de primera noche que los controles. La ausencia de diferencias entre los dos grupos en el EEG típico del sueño (delta, theta y sigma) sugiere que los insomnes tienen preservada la función homeostásica del sueño. La ausencia de diferencias en la PSG de los insomnes y controles indica que la dificultad para conciliar el sueño del grupo de insomnes no se encuentra en estímulos externos ambientales ni en condiciones circunstanciales y sugiere que se debe a alteraciones más permanentes. El conjunto de estas evidencias apunta hacia una alteración de la vigilia en concordancia con las hipótesis que proponen que el insomnio tiene un componente primordial de activación fisiológica y psicológica. La atención depende, además del nivel de vigilancia, de las regiones frontales que, junto con las áreas posteriores de asociación, conforman una red esencial para la atención dirigida endogenamente. La presencia de ritmo alfa en las regiones frontales y su ausencia en las áreas posteriores durante la etapa 2 en los insomnes podría reflejar la permanencia de cierto nivel de atención endógena durante la etapa 2 del PIS y podría constituir un mecanismo alterado del sistema frontal subyacente a la dificultad para iniciar el sueño. Resumen en inglés Difficulty in sleep initiation, with or without objective signs, is one of the most frequent complaints in primary insomniacs. The electroencephalographic (EEG) activity characteristic of waking (beta and alpha oscillations) is gradually replaced by the EEG signs of sleep (sleep spindles and theta/delta waves) during the sleep onset period (SOP) in normal subjects. The decrease in fast oscillations occurs at the first signs of stage 1, whereas theta and delta increase occ (mas) urs later, indicating that waking promoting mechanisms are turned off before sleep-promoting mechanisms are fully started. It could be therefore hypothesized that difficulty in sleep initiation in insomniacs might be due to either a hyperactivation of waking promoting systems, a weakness of sleep promoting mechanisms or an imbalance between them. Quantitative EEG analysis has revealed higher beta during wakefulness, as well as during sleep and lower slow (delta) activity in insomniacs. The presence of alpha activity during cognitive information processing, especially of slow alpha activity in relation to attention, as well as in some pathologies associated to sleep disturbances, has suggested that alpha activity during sleep is a sign of activation; however, alpha activity during sleep has been less studied in insomniacs. Only broad bands have been considered in all of the aforementioned studies, and in almost all of them the analyses were restricted to central regions. It is therefore important to study the entire frequency spectrum of EEG activity in insomniacs. Sleep initiation does not occur simultaneously over the entire cortex but starts as a local process which gradually invades the rest of the cortex, in which the frontal lobes play a crucial role. Frontal and parietal regions are part of an important network involved in attention and conduction of thought. Thus, quantitative analysis of narrow EEG bands and their distribution in the cerebral cortex may contribute to a better understanding of neural mechanisms compromised in etiology of sleep initiation in primary insomnia. The main objective of the present investigation was, therefore, to analyze the spectral power of narrow EEG bands in the 19 derivations of the 10-20 International System during SOP in primary insomniacs with difficulty in sleep initiation. Given that one of the main complaints of insomniacs is the difficulty to initiate sleep and that hyperarousal is one of the factors proposed to be involved in the etiology of insomnia, EEG activity during SOP of the first night in the laboratory was analyzed to control activating effects of surrounding circumstances and isolate permanent EEG characteristics. Subjects were 19-34 years old, right-handed with primary sleep insomnia, which were thoroughly screened via structured psychiatric, medical and sleep interviews and scales. Subjects were younger and the age range was narrower than in other EEG frequency spectral content studies of primary insomniacs to avoid confounding effects of changes in sleep architecture or in EEG generated by development. All patients met the criteria for primary insomnia with sleep onset difficulty and impaired daytime function on three or more nights per week for at least six months and with no medical, psychiatric or neurological conditions; they were not medicated and had no other sleep disorders. Participants taking sleep medications or other drugs (urine test), respiratory or sleep disorders such as apnea and periodic limb movements (PSG) were excluded. The control group (n = 9) was matched for age and dexterity, but had no complaints of insomnia and reported their sleep as restorative and satisfactory. All participants underwent a single night of standard polysomnography (EEG, EOG and EMG) in the laboratory. In addition, the 19 electrode sites of the 10-20 International System referred to ipsilateral earlobes, oral-nasal airflow and anterior tibialis EMG were recorded. PSG was scored in 30 sec epochs, blind to the subject group according to Rechtschaffen and Kales criteria. EEG from SOP (lights out to consolidate sleep), defined as 3 consecutive minutes of delta sleep, was digitized at 1024 Hz with 12 bits resolution and filter settings of 0.03-70 Hz. EEG was segmented into two-sec non-overlapping epochs and inspected for artifacts. All artifact-free epochs were Fast Fourier Transformed and absolute (AP) and relative power (RP: AP in each Hz bin/total spectrum power × 100) was obtained for 1 Hz bins. AP and RP was log-transformed before statistical analysis, and was averaged over each derivation and sleep stage of SOP. Group differences were compared by means of Student's t tests and probability level was set at p> with decreased total sleep time, decreased sleep efficiency index and REM sleep percentage compared to normal values for the 20-30 age decade; PSG variables were not significantly different between the two groups except for wakefulness percentage during SOP. Insomniacs did differ from controls in subjective estimation of sleep quality and continuity in spite of similar PSG. The absence of significant differences between insomniacs and controls in sleep EEG activity (delta, theta and sigma frequencies) suggests that sleep homeostatic function is preserved in insomniacs, which agrees with results obtained in other studies after partial sleep deprivation. The absence of a stronger promoting effect of insomnia in the insomniac group by the first recording night indicates that EEG characteristics found in this group cannot be attributed to external stimuli nor surrounding circumstances and rather suggests a more stable alteration; however, further studies of larger groups and other age spans are needed to confirm present results. The evidence mentioned above suggests an imbalance between waking and sleep promoting mechanisms in primary insomniacs with difficulty in sleep initiation and sleep perception. Attention depends not only on vigilance level, but also on frontal regions which, together with posterior association areas, conform an essential network for purposive endogenously guided attention. The presence in insomniacs of alpha activity in frontal regions, which is a sign of top-down control of attention, and its absence in posterior regions during stage 2 suggests the persistence of a certain level of endogenous attention during stage 2 of SOP, which contributes in turn to the subjective perception of sleep onset difficulties and bad sleep quality.

Scientific Electronic Library Online (Spanish)

5

Determinación de la resistencia a insecticidas y sus mecanismos bioquímicos en 2 cepas de Culex quinquefasciatus procedentes de Santiago de Cuba

RODRÍGUEZ, MARÍA M.; BISSET, JUAN; RODRÍGUEZ, ILEANA; DÍAZ, CRISTINA
1997-12-01

Resumen en español RESUMEN Se analizó el comportamiento de la resistencia a 3 insecticidas organofosforados (malatión, clorpirifos y pirimifos metil), 3 piretroides (deltametrina, lambdacialotrina y cipermetrina) y 1 carbamato (propoxur) en poblaciones de Culex quinquefasciatus provenientes de 2 municipios de la provincia de Santiago de Cuba. Los valores del factor de resistencia determinaron que existe resistencia para malatión y clorpirifos. Sin embargo, a pesar de la existencia de una (mas) alta frecuencia en los mecanismos de esterasas elevadas y acetilcolinesterasa alterada, no se observó resistencia a pirimifos metil, lo cual corroboró la no afectación de este insecticida por estos mecanismos seleccionados en nuestras poblaciones de Culex quinquefasciatus. Se observó resistencia a los insecticidas piretroides deltametrina y lambdacialotrina en Santiago de Cuba, y moderada para cipermetrina en Santiago y San Luis; también se encontró en San Luis resistencia a deltametrina, pero moderada a lambdacialotrina. Los resultados obtenidos a partir del uso de los sinergistas S,S,S tributil fosfotritiado (DEF) y piperonil butóxido (PB) indicaron que los mecanismos de resistencia de esterasas inespecíficas y las oxidasas de función múltiple están involucradas en la resistencia a piretroides en ambas cepas provenientes de Santiago de Cuba y San Luis. Se determinó, mediante las pruebas bioquímicas, que existió una alta frecuencia de los mecanismos de esterasas y acetilcolinesterasa alterada. Los resultados de las electroforesis en gel de poliacrilamida (PAGE), mostraron que la esterasa B1 aparece con mayor frecuencia asociada con las esterasas A6 y B6. Se infirió que esta asociacioón pudiera estar vinculada con la resistencia a piretroides. Resumen en inglés It was analyzed the behavior of the resistance of 3 organophosphated insecticides (malathion, clorpirifos and methyl-pyrimifos), 3 pyrethroids (deltamethrin, lambda-cyhalothrin and cypermethrin), and 1 carbamate (propuxur) in populations of Culex quinquefasciatus from 2 municipalities of the province of Santiago de Cuba. The values of the resistance factor proved that there is resistance to malathion and clorpirifos. However, in spite of the existance of a high frequency (mas) of the mechanisms of elevated esterases and altered acetylcholinesterase no resistance to methyl-pymirifos, was observed which demostrated that this insecticide is not affected by these mechanisms selected in our populations of Culex quinquefasciatus. There was resistence to deltamethrin, and lambda-cyhalothrin in Santiago de Cuba, whereas it was moderate to cypermethrin in Santiago and San Luis. Resistance to delta-methrin was also found in San Luis, but it was mild to lambda-cyhalothrin. The results obtained from the use of the synergists S,S,S tributyl phosphotritiade (DBF) and piperonyl butoxide (PB) indicated that the mechanisms of resistance of unspecific esterases and oxidases of multiple function are involved in the resistance to pyrethroids in both strains from Santiago de Cuba and San Luis. It was determined by the biochemical tests that there existed a high frequency of the mechanisms of esterases and altered acetyl-cholinesterase. The results of the polyacrylamide gel electrophoresis (PAGE) showed that esterase B1 appears more frequently associated with esterases A6 and B6. It was inferred that this association coul be connected with the resistance to pyrethroids.

Scientific Electronic Library Online (Spanish)

9

The MiniBooNE detector

Sorel, Michel; Aguilar-Arevalo, A. A.; Anderson, C. E.; Bartoszek, L. M.; Bazarko, A.; Brice, S. J.; Brown, B. C.; Bugel, L.; Cao, J.; Coney, L.; Conrad, J. M.; Cox, D. C.; Curioni, A.; Djurcic, Z.; Finley, D. A.; Fleming, B. T.; Ford, R.; García, F. G.; Garvey, G. T.; Green, C.; Green, J. A.; Hart, T. L.; Hawker, E.; Imlay, R.; Johnson, R. A.; Karagiorgi, G.; Kasper, P.; Katori, T.; Kobilarcik, T.; Kourbanis, I.; Koutsoliotas, S.; Laird, E. M.; Linden, S. K.; Link, J. M.; Liu, Y.; Louis, W. C.; Mahn, K. B. M.; Marsh, W.; Martin, P. S.; McGregor, G.; Metcalf, W.; Meyer, H. O.; Meyers, P. D.; Mills, F.; Mills, G. B.; Monroe, J.; Moore, C. D.; Nelson, R. H.; Nguyen, V. T.; Nienaber, P.; Nowak, J. A.; Ouedraogo, S.; Patterson, R. B.; Perevalov, D.; Polly, C. C.; Prebys, E.; Raaf, J. L.; Ray, H.; Roe, B. P.; Russell, A. D.; Sandberg, V.; Sands, W.; Schirato, R.; Schofield, G.; Schmitz, D.; Shaevitz, M. H.; Shoemaker, F. C.; Smith, D.; Soderberg, M.; Spentzouris, P.; Stancu, I.; Stefanski, R. J.; Sung, M.; Tanaka, H. A.; Tayloe, R.; Tzanov, M.; Van de Water, R.; Wascko, M. O.; White, D. H.; Wilking, M. J.; Yang, H. J.; Zeller, G. P.; Zimmerman, E. D.; MiniBooNE Collaboration
2009-02-01

Digital.CSIC (Spain)

10

Superscaling analysis of inclusive electron scattering and its extension to charge-changing neutrino-nucleus cross sections beyond the relativistic Fermi gas approach

Antonov, A. N.; Ivanov, M. V.; Gaidarov, M. K.; Moya de Guerra, Elvira; Caballero, Juan Antonio; Barbaro, M. V.; Udias, J. M.; Sarriguren, Pedro
2006-11-10

Digital.CSIC (Spain)

11

Retiro precoz de esteroides en la inmunosupresión del trasplante renal pediátrico/ Early steroid withdrawal in pediatric renal transplantation

Delucchi B, Angela; Valenzuela A, Marcela; Ferrario B, Mario; Lillo D, Ana María; Guerrero G, José Luis; Rodríguez S, Eugenio; Cano Sch, Francisco; Cavada Ch, Gabriel; Godoy L, Jorge; Rodríguez H, Jorge; González G, Gloria; Buckel B, Erwin; Contreras M, Luis
2006-11-01

Resumen en inglés Background: Cardiovascular risk, growth failure and the new immunosuppressive drugs, have encouraged steroid withdrawal or total avoidance with promising results in renal transplant (Tx) immunosuppression. Aim: To evaluate a new immunosuppressor protocol with early withdrawal of steroids in pediatric kidney transplant. Patients and methods: Prospective study in pediatric patients older than 1 year and low immunological risk. Group A (n =28): steroids in decreasing doses u (mas) ntil day 7 post Tx, tacrolimus (FK) and micophenolate mofetil (MMF). Group B (n =28) control: steroids, cyclosporine and azathioprine or steroids, FK and MMF. In both groups the induction therapy included basiliximab. Anthropometric and biochemical variables (renal function, lipid profile, hematological, blood glucose and acid-base equilibrium), acute rejection and CMV infection, were evaluated. Mean values and variations for continuous variables were calculated at months 1, 6, 12 and 18. Results: Two children were withdrawn before month 2, one had an untreatable diarrhea and the second died due to Aspergillus septicemia. Mean values at months 1, 6, 12 and 18 for groups A and B: Creatinine clearence (ml/min): 85.4 vs 89; 79.9 vs 83; 89 vs 80; 79.8 vs 80.6 (p: ns); hematocrit (%): 28.8 vs 30.4; 31.7 vs 34.4; 34.4; 32.4 vs 34.8; 34.4 vs 35.5 (p: ns). Total cholesterol (mg/dl): 151 vs 206; 139 vs 174; 138 vs 186; 140 vs 180 (p

Scientific Electronic Library Online (Spanish)

13

Putative prethymic T cell precursors within the early human embryonic liver: a molecular and functional analysis

Sánchez, María J.; Gutiérrez Ramos, José Carlos; Fernández, Edgar; Leonardo, Esther; Lozano, Juan José; Martínez-Alonso, Carlos; Toribio, María Luisa
1993-01-01

Digital.CSIC (Spain)

14

Promoter-specific inhibition of transcription by daunorubicin in Saccharomyces cerevisiae

Marín, Silvia; Mansilla, Sylvia; García-Reyero, Natàlia; Rojas, Marta; Portugal, José; Piña, Benjamín
2002-11-15

Digital.CSIC (Spain)

15

Novel topologies of cascade ΣΔ modulators for low-voltage wideband applications

Morgado, Alonso; Río Fernández, Rocío del; Rosa Utrera, José Manuel de la

This work presents two novel topologies ofcascade ΣΔ modulators with unity signal transferfunction that avoid the need of digital filtering in the error cancellation logic. The combination of these two aspects make them highly tolerant to noise leakages, very robust to non-linearities of the circu...

DRIVER (Spanish)

16

Novel topologies of cascade ΣΔ modulators for low-voltage wideband applications

Morgado, Alonso; Río Fernández, Rocío del; Rosa Utrera, José Manuel de la
2007-08-01

Digital.CSIC (Spain)

18

Involvement of the interleukin 2 pathway in the rearrangement and expression of both [alfa/beta] and [gamma/delta] T cell receptor genes in human T cell precursors

Toribio, María Luisa; Hera, Antonio de la; Borst, Jannie; Borst, Jannie; Marcos, Miguel A. R.; Márquez, Carlos; Alonso, José M.; Bárcena, Alicia; Martínez-Alonso, Carlos
1988-12-01

Digital.CSIC (Spain)

19

Identification of dynorphin a from zebrafish: A comparative study with mammalian dynorphin A

González-Nuñez, V.; Marrón Fernández de Velasco, E.; Arsequell, Gemma; Valencia Parera, Gregorio; Rodríguez, R. E.
2007-06-19

Digital.CSIC (Spain)

20

High-Level Synthesis of Switched-Capacitor, Switched-Current and Continuous-Time ΣΔ Modulators Using SIMULINK-Based Time-Domain Behavioral Models

Ruiz Amaya, Jesús; Rosa Utrera, José Manuel de la; Fernández, Francisco V.; Medeiro, Fernando; Río Fernández, Rocío del; Pérez Verdú, Belén; Rodríguez Vázquez, Angel
2005-09-01

Digital.CSIC (Spain)

23

Evaluación ecológica rápida de la ictiofauna en cinco localidades del delta del río Orinoco, Venezuela/ Fast ecological evaluation of the ichthyofauna in five localities of the Orinoco river delta, Venezuela/ Avaliação ecológica rápida da ictiofauna em cinco localidades do delta do rio Orinoco, Venezuela

Ortaz, Mario; Machado-Allison, Antonio; Carrillo, Víctor
2007-09-01

Resumen en portugués Realizou-se uma Avaliação Ecológica Rápida da ictiofauna em cinco áreas (áreas piloto, AP) do delta do rio Orinoco que incluíram ao delta Superior (AP1), Médio (AP2 e AP5) e Inferior (AP3 e AP4), todas localizadas, com exceção de AP1, dentro da Reserva de Biosfera Delta do Orinoco (RBDO). Realizaram-se três campanhas de campo desde set/2002 a maio/2003. Avaliaram-se 14-16 estações que incluíram córregos principais, secundários e lagos. A coleta de peixes s (mas) e realizou com redes de cerco experimentais em horas diurnas (8:00-18:30) com um esforço neto total de pesca de 23,2 e 37,6h para a primeira e segunda campanha de coleta, respectivamente. Capturaram-se 80 espécies, 7 das quais são novos registros para o delta, o qual possui ~394 espécies, das que 50% estão presentes na RBDO. Em AP1 se obteve a maior riqueza, diversidade e equidade de espécies; aí existe uma série de ambientes lacunares únicos no delta e provavelmente representa uma fonte importante de recrutas para outras áreas do mesmo. Os invertebrados bênticos, o nécton e a matéria orgânica de origem terrestre foram as três grandes fontes alimentícias da ictiofauna deltaica avaliada e sua importância relativa variou espacial e temporalmente. Este estudo amplia a distribuição espacial do ciclídeo forâneo Caquetaia kraussii. A alteração antrópica sobre a ictiofauna do delta do Orinoco pode considerar-se baixa até agora e a maior pressão têm lugar no delta Superior, sem evidência de ações que a revertam. Resumen en español Se realizó una Evaluación Ecológica Rápida de la ictiofauna en cinco áreas (áreas piloto, AP) del delta del río Orinoco que incluyeron al delta Superior (AP1), Medio (AP2 y AP5) e Inferior (AP3 y AP4), todas ubicadas, a excepción de AP1, dentro de la Reserva de Biosfera Delta del Orinoco (RBDO). Se realizaron tres campañas de campo desde set/2002 a may/2003. Se evaluaron entre 14 y 16 estaciones que incluyeron caños principales, secundarios y lagunas. La colecta (mas) de peces se realizó con redes de ahorque experimentales en horas diurnas (8:00-18:30) con un esfuerzo neto total de pesca de 23,2 y 37,6h para la primera y segunda campaña de colecta, respectivamente. Se capturaron 80 especies, 7 de las cuales son nuevos registros para el delta, el cual posee ~394 especies, de las que 50% están presentes en la RBDO. En AP1 se obtuvo la mayor riqueza, diversidad y equidad de especies; allí existe una serie de ambientes lagunares únicos en el delta y probablemente representa una fuente importante de reclutas para otras áreas del mismo. Los invertebrados bénticos, el necton y la materia orgánica de origen terrestre fueron las tres grandes fuentes alimenticias de la ictiofauna deltaica evaluada y su importancia relativa varió espacial y temporalmente. Este estudio amplía la distribución espacial del cíclido foráneo Caquetaia kraussii. La alteración antrópica sobre la ictiofauna del delta del Orinoco puede considerarse baja hasta ahora y la mayor presión tiene lugar en el delta Superior, sin evidencia de acciones que la reviertan. Resumen en inglés A Rapid Ecological Assessment of the ichthyofauna was performed on five pilot areas (AP) of the Orinoco river delta. The pilot areas included the superior delta (AP1), middle delta (AP2 and AP5) and low delta (AP3 and AP4). All of them, except AP1, are included in the Orinoco Delta Biosphere Reserve (ODBR). Three campaigns were carried out from Sep/2002 to May/2003. Between 14 and 16 sampling stations were evaluated, including principal and secondary channels and lagoons. (mas) Fishes were collected using gillnets during daylight hours (8:00-18:30) with a total net effort of 23.2h for the first campaign and 37.6h for the second one. A total of 80 species were collected, 7 of them new records for the area. The Orinoco delta harbors ~394 species, 50% of which are within the ODBR. Diversity, evenness and species richness were high in AP1, where a series of lentic environments unique in the Orinoco river delta exist and could function as an important source of recruitments for other areas. Benthic invertebrates, nekton and organic allochthonous matter from terrestrial origin were the principal food resources used by fishes, with a varying spatial and temporal relative importance. This study increases the spatial distribution of the exotic cichlid Caquetaia kraussii. The anthropic environmental changes that could affect the ichthyofauna is considered low to this date but a moderate pressure was found on the upper delta area, without there being evidence of actions to reverse it.

Scientific Electronic Library Online (Spanish)

25

Esteroides en días alternos en trasplante renal pediátrico/ Alternate-day steroids in paedriatric renal transplantation

Villagra C, Jorge; Cano Sch, Francisco; Delucchi B, Angela; Rodríguez S, Eugenio
2001-09-01

Resumen en español El severo retraso de talla es una de las complicaciones de la insuficiencia renal crónica que más afectan la normal integración escolar y social del niño urémico. Este se prolonga al período postrasplante renal, en parte por el uso permanente de esteroides. Objetivo: Evaluar el efecto de la terapia esteroidal en días alternos sobre el crecimiento del paciente pediátrico trasplantado renal, en comparación con el uso de prednisona en dosis diaria. Pacientes y Méto (mas) do: Los pacientes trasplantados renales menores de 15 años, al momento del trasplante, que durante el primer año de trasplante mantuvieron una creatinina Resumen en inglés Severe growth retardation is one of the complications of chronic renal failure that is the most important factor that affects the normal social and academic integration of the uraemic child. This continues to be a problem in the post transplant period, in part caused by the continuing use of steroid immunosuppression. Objective: to evaluate the effect of using alternate day steroids on the growth of transplanted children compared with those treated with daily steroids. Pa (mas) tients and methods: the children were less than 15 years at the time of transplant, and maintained a creatinine of less than 1.5 mg/dl during the 1st year post-transplant. There were no acute rejections of the graft. Group 1 were allocated to alternate-day prednisone, but maintaining the same cumulative dose. Other immunosuppressive therapy remained unchanged. Group 2 continued with the same daily dose of prednisone. Analysis included height/age (z), growth velocity (delta Z) and renal function during a 4 - year study period. The dose of prednisone was between 0.12 and 0.16 mg/kg/day and in the case of alternate-day, dosage was doubled. Statistical analysis used the paired t-test for growth and simple linear regression for renal function, a p value of 28 patients, 15 boys, average age 9.9 + 2.3 years (ns). In the 4 years of follow up the z values of growth were -2.27/-2.24, -2.09/-2.14, -2.21/-2.41, -1.85/-2.68 and -2.03/-3.12 (p

Scientific Electronic Library Online (Spanish)

26

Cosmological horizon modes and linear response in de Sitter spacetime

Anderson, Paul R.; Molina-Paris, C.; Mottola, E.
2009-10-06

Digital.CSIC (Spain)

27

Clock Jitter Error in Multi-bit Continuous-Time Sigma-Delta Modulators with Non-Return-to-Zero Feedback Waveform

Tortosa, Ramón; Rosa Utrera, José Manuel de la; Fernández, Francisco V.; Rodríguez Vázquez, Angel
2008-01-01

Digital.CSIC (Spain)

28

Climatic forcing on hydrography of a Mediterranean bay (Alfacs Bay)

Solé, Jordi; Turiel, Antonio; Estrada, Marta; Llebot, Clara; Blasco, Dolors; Camp, Jordi; Delgado, Maximino; Fernández-Tejedor, Margarita; Diogène, Jorge
2008-05-09

Digital.CSIC (Spain)

29

Biochemical mechanisms of resistance in Daphnia magna exposed to the insecticide fenitrothion

Damásio, Joana B.; Guilhermino, Lúcia; Soares, Amadeu M. V. M.; Riva, M. Carmen; Barata Martí, Carlos
2007-08-30

Digital.CSIC (Spain)

30

Análisis de los ruidos respiratorios y sibilancias en fiposis quística/ Breath sound analysis and wheezing in cystic fiposis

Sánchez D, Ignacio; Vizcaya A, Cecilia; García P, Daniela
2003-11-01

Resumen en español Las sibilancias son sonidos musicales que provienen de las vías aéreas obstruidas, que dependen del flujo aéreo, una presión crítica y una distorsión geométrica de la vía aérea. Nuestro objetivo fue caracterizar las sibilancias y el espectro de los ruidos respiratorios en pacientes con Fiposis Quística (FQ), con el propósito de conocer la repercusión acústica de la obstrucción ponquial en este grupo de pacientes. Se estudiaron 14 pacientes (8 niños), de eda (mas) d 14,3 ± 2 años (8 + D.S.), seis niños fueron portadores de la mutación deltaF508/deltaF508. La espirometría basal demostró CVF: 56 ± 15%, VEF1:44 ± 12%, FEF25-75: 40 ± 14% y SaO2: 93,4 + 2%. Los pacientes respiraron a través de un pneumotacómetro con flujos de 0,5 ± 0,05 l/s. Los ruidos respiratorios se grabaron utilizando sensores de contacto en el espacio supraesternal y en la pared torácica correspondiente al lóbulo inferior derecho. Las señales de sonidos se filtraron, amplificaron y se aplicó un análisis de Fourier a los sonidos dentro de la ventana de flujo previamente determinada. Desde el espectro de sonidos analizado, se obtuvo el cálculo de la intensidad con bajas frecuencias (P1= 100-200 Hz) y con altas frecuencias (P2= 400-2 000 Hz). Se midió las frecuencias bajo las cuales el 50% (F50) y 99% (SEF99) se ubicó el espectro de la intensidad entre 100-2 000 Hz. Luego de obtener un registro basal, los pacientes recibieron salbutamol inhalado (200 mg) y 15 minutos después se repitieron las mediciones. Solo en 6/14 pacientes se obtuvo la onda sinusoidal característica de las sibilancias, los otros pacientes presentaron ondas complejas. Hubo un aumento significativo en P1y una disminución en P2, durante la inspiración después de salbutamol (p Resumen en inglés Wheezes are musical sounds caused by obstructed airways and depend on airflow, a critical pressure and a geometrical airway distortion. Objective to characterize wheezing and the lung sound spectra in cystic fiposis (CF). Patient and Methods: 14 patients (8 boys), aged 14.± 2 years, 6 children had deltaF508/deltaF508 mutation. Subjects peathed through a pneumotachograph at flows of 0.5 ± 0.05 l/s. Respiratory sounds were recorded using contact sensors on the supra-stern (mas) al notch and on the thoracic region corresponding to the right lower lobe. Sound signals were low-pass filtered, amplified and Fourier analisis was applied to sounds within the target flow range. From averaged spectra, power at low (100-200 Hz = P1) and high frequencies (400-2 000Hz = P2) were calculated. We measured the frequencies below in which 50% (F50) and 99% (SEF99) of the spectral power between 100-2 000 Hz were contained. After baseline recording, patients received inhaled salbutamol (200 mcg) and 15 minutes later the measurements were repeated. Results:Baseline spirometry was FVC ± 15%, FEV(1)44 ± 12%, FEF25-75: 40 ± 14% and SaO(2)93.4 ± 2%. Only in 6/14 patients we obtained a sinusoidal waveform of a typical wheeze, the others had complex waveforms. There was a significant increase in P1and decrease in P2during inspiration after salbutamol (p

Scientific Electronic Library Online (Spanish)

31

Analysis of Error Mechanisms in Switched-Current Sigma-Delta Modulators

Rosa Utrera, José Manuel de la; Pérez Verdú, Belén; Medeiro, Fernando; Río Fernández, Rocío del; Rodríguez Vázquez, Angel
2004-01-01

Digital.CSIC (Spain)

32

Analysis and Modeling of the Non-Linear Sampling Process in Switched-Current Circuits - Application to Bandpass Sigma-Delta Modulators

Rosa Utrera, José Manuel de la; Pérez Verdú, Belén; Medeiro, Fernando; Río Fernández, Rocío del; Rodríguez Vázquez, Angel
2001-08-01

Digital.CSIC (Spain)

33

A uniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptor

Teichert, Russell W.; Rivier, Jean; Torres, Josep Lluís; Dykert, John; Miller, Charleen; Olivera, Baldomero M.
2005-01-19

Digital.CSIC (Spain)

34

A novel function of DELTA-NOTCH signalling mediates the transition from proliferation to neurogenesis in neural progenitor cells

Hämmerle, Barbara; Tejedor, Francisco J.

15 pages, 9 figures.-- PMID: 18000541 [PubMed].-- PMCID: PMC2064965. | Supporting information (Suppl. figures S1-S3) available at: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0001169#s5 | A complete account of the whole developmental process of neurogenesis involves understand...

DRIVER (Spanish)

36

A new cascade ΣΔ modulator for low-voltage wideband applications

Morgado, Alonso; Río Fernández, Rocío del; Rosa Utrera, José Manuel de la

A new cascade ΣΔ modulator architecture with unity signal transfer function is presented, which avoids the need for digital filtering in the error cancellation logic. The combination of these two aspects makes it highly tolerant to noise leakages, very robust to nonlinearities of the circuitry and e...

DRIVER (Spanish)

37

A new cascade ΣΔ modulator for low-voltage wideband applications

Morgado, Alonso; Río Fernández, Rocío del; Rosa Utrera, José Manuel de la
2007-08-01

Digital.CSIC (Spain)

38

A Simulink-Based Approach for Fast and Precise Simulation of Switched-Capacitor, Switched-Current and Continuous-Time Sigma-Delta Modulators

Moreno Reina, Javier; Rosa Utrera, José Manuel de la; Medeiro, Fernando; Romay, Rafael; Río Fernández, Rocío del; Pérez Verdú, Belén; Rodríguez Vázquez, Angel
2003-05-01

Digital.CSIC (Spain)