Sample records for TRANSFORMACIONES CELULARES (cell transformations)
from WorldWideScience.org

Sample records 1 - 20 shown. Select sample records:



1

β-Catenin Regulation during the Cell Cycle: Implications in G2/M and Apoptosis

Olmeda, David; Castel, Susanna; Vilaró, Senén; Cano García, Amparo
2003-07-01

Digital.CSIC (Spain)

2

v-erbA oncogene induces invasiveness and anchorage-independent growth in cultured glial cells by mechanisms involving platelet-derived growth factor

Llanos, Susana; Iglesias, Teresa; Riese, Hans H.; Garrido, Teresa; Caelles, Carme; Muñoz Terol, Alberto
1996-03-01

Digital.CSIC (Spain)

3

ZmXTH1, a new xyloglucan endotransglucosylase/hydrolase in maize, affects cell wall structure and composition in Arabidopsis thaliana

Genovesi, Valeria; Fornalé, Silvia; Fry, Stephen C.; Ruel, Katia; Ferrer, Pau; Encina, Antonio; Sonbol, Fathi-Mohamed; Bosch, Josep; Puigdomènech, Pere; Rigau, Joan; Caparrós Ruiz, David
2008-03-02

Digital.CSIC (Spain)

4

Use and improvement of microbial redox enzymes for environmental purposes

García-Arellano, Humberto; Alcalde Galeote, Miguel; Ballesteros, Antonio
2004-08-02

Digital.CSIC (Spain)

5

Type 3 Iodothyronine Deiodinase Is Selectively Expressed in Areas Related to Sexual Differentiation in the Newborn Rat Brain

Escámez, María José; Guadaño-Ferraz, Ana; Cuadrado, Ana; Bernal Carrasco, Juan
1999-11-01

Digital.CSIC (Spain)

6

Tumores palpebrales benignos derivados de los folículos pilosos en adultos/ Benign hair-follicle derived eyelids tumors in adults

Mencía Gutiérrez, E; Gutiérrez Díaz, E; Ricoy, JR; Gómez Ledesma, I; Monescillo, J; García Torre, JP
2002-11-01

Resumen en español Objetivo: Los tumores palpebrales benignos que derivan de los folículos pilosos con frecuencia son mal diagnosticados clínicamente. Este grupo incluye el pilomatricoma, el tricoepitelioma, el tricolemoma, el tricoblastoma y la queratosis folicular invertida. Métodos: Revisamos 17 tumores de este tipo, que hemos tratado entre 1992 y 2000. Su excisión quirúrgica fue su tratamiento en todos los casos. Resultados: La edad media fue de 44,5 años (rango 13-80 años). Diez (mas) fueron mujeres y 7 hombres. Los pilomatricomas y los tricoepiteliomas constituyeron el 76,5% del total de este tipo de tumores. Todos los tricoepiteliomas se presentaron de forma aislada y sin antecedentes familiares. El resto (23,5%) fueron tricolemomas, un tricoblastoma y una queratosis folicular invertida. Ninguno tuvo recurrencia local y por tanto ninguno hizo una transformación maligna tras una media de 3,1 años de seguimiento. El más frecuente de este tipo de tumores en nuestra serie fue el pilomatricoma (9 casos). Conclusiones: Los tumores benignos palpebrales derivados de los folículos pilosos son infrecuentes. Pueden ser confundidos con un carcinoma de células basales cuando nos basamos sólo en la exploración clínica y únicamente los pilomatricomas pueden semejar una lesión benigna. Deben ser resecados con márgenes de seguridad, y todas las lesiones deben ser estudiadas histopatológicamente para confirmar el diagnóstico, ya que es imposible obtener un 100% de correlación clínico-patológica en el diagnóstico de los tumores palpebrales. Resumen en inglés Purpose: Benign eyelid neoplasms derived from hair follicles are frequently misdiagnosed, including pilomatricoma, trichoepithelioma, trichilemmoma, trichoblastoma and inverted follicular keratosis. Methods: We reviewed 17 tumors seen in the last 9 years, between 1992 and 2002. Excisional biopsy constituted the treatment in all cases. Results: The mean age was 44.5 years (range 13-80 years). Ten were women and 7 men. Pilomatricoma and trichoepithelioma accounted for 76.5% (mas) of all neoplasms. All trichoepitheliomas were found as solitary tumors and no patient had a history of familial trichoepithelioma. The remaining neoplasms (23.5%) were trichilemmomas, trichoblastoma and inverted follicular keratosis. No patient recurred locally and there were no malignant transformations after a mean follow-up of 3.1 years. The most frequent hair follicle neoplasms in our series was pilomatricoma (9 cases). Conclusions: Benign hair follicle neoplasms are rare in the eyelid. Most can simulate a basal cell carcinoma when evaluation is based on clinical evidence alone, and only the pilomatricoma may resemble a benign neoplasm. Thereby they must be excised with free surgical margins. All excised eyelid lesions should be sumitted for histopathologic examination because it is not possible to obtain 100% accuracy in diagnosing eyelid tumors.

Scientific Electronic Library Online (Spanish)

7

Transgenic Medicago truncatula plants that accumulate proline display notrogen-fixing activity with anhanced tolerance to osmotic stress

Verdoy, D.; Coba de la Peña, Teodoro; Redondo, F. J.; Lucas, M. Mercedes; Pueyo, José J.
2006-01-01

Digital.CSIC (Spain)

9

Transformation of Escherichia coli with DNA from Saccharomyces cerevisiae cell lysates

Adam, Ana Cristina; González Blasco, Gracia; Rubio Texeira, Marta; Polaina Molina, Julio
1999-12-01

Digital.CSIC (Spain)

10

Transcriptomal profiling of the cellular transformation induced by Rho subfamily GTPases

Berenjeno, Inmaculada M.; Núñez, Fátima; Bustelo, Xosé R.
2007-06-01

Digital.CSIC (Spain)

11

Transcriptomal profiling of site-specific Ras signals

Agudo-Ibáñez, Lorena; Núñez, Fátima; Calvo González, Fernando; Berenjeno, Inmaculada M.; Bustelo, Xosé R.; Crespo, Piero
2007-11-01

Digital.CSIC (Spain)

13

The significance of sexual versus asexual cyst formation in the life

Figueroa, Rosa Isabel; Bravo, Isabel; Garcés, Esther
2008-01-01

Digital.CSIC (Spain)

14

The plastidial 2-C-methyl-D-erythritol 4-phosphate pathway provides the isoprenyl moiety for protein geranylgeranylation in tobacco BY-2 cells

Gerber, Esther; Hemmerlin, Andréa; Hartmann, Michael; Heintz, Dimitri; Hartmann, Marie-Andrée; Mutterer, Jerome; Rodríguez Concepción, Manuel; Boronat, Albert; Van Dorsselaer, Alain; Rohmer, Michel; Crowell, Dring N.; Bach, Thomas J.
2009-01-09

Digital.CSIC (Spain)

15

The peroxisome proliferator-activated receptor gamma is an inhibitor of ErbBs activity in human breast cancer cells

Pignatelli, Miguel; Cortés-Canteli, Marta; Lai, Cary; Santos, Ángel; Pérez Castillo, Ana
2001-11-01

Digital.CSIC (Spain)

17

The Epithelial Mesenchymal Transition Confers Resistance to the Apoptotic Effects of Transforming Growth Factor β in Fetal Rat Hepatocytes

Valdés, Francisco; Álvarez, Alberto M.; Locascio, Annamaria; Vega, Sonia; Herrera, Blanca; Fernández, Margarita; Benito, Manuel; Nieto, M. Ángela; Fabregat, Isabel
2002-01-01

Digital.CSIC (Spain)

18

Temperature-dependent hypermutational phenotype in recA mutants of Thermus thermophilus HB27

Castán, Pablo; Casares, Lorena; Barbé, Jordi; Berenguer, José
2003-01-01

Digital.CSIC (Spain)

19

Structural and magnetic studies in ferrihydrite nanoparticles formed within organic-inorganic hybrid matrices

Silva, Nuno Joâo O.; Amaral, Vitor S.; Carlos, Luis D.; Rodríguez-González, B.; Liz-Marzán, Luis M.; Millán, Ángel; Palacio, Fernando; Zea Bermúdez, V. de
2006-09-01

Digital.CSIC (Spain)

21

Somatic Embryogenesis in Chestnut. New Approaches

Ballester, Antonio; Corredoira, Elena; Viéitez, Francisco Javier; Viéiztez, Ana M.
2005-12-22

Digital.CSIC (Spain)

22

Snail1 suppresses TGF-β-induced apoptosis and is sufficient to trigger EMT in hepatocytes

Franco, D. Lorena; Mainez, Jèssica; Vega, Sonia; Sancho, Patricia; Murillo, Miguel M.; Frutos, Cristina A. de; Castillo, Gaelle del; López-Blau, Cristina; Fabregat, Isabel; Nieto, M. Ángela
2010-01-01

Digital.CSIC (Spain)

23

Snail family members and cell survival in physiological and pathological cleft palates

Martínez-Álvarez, Concepción; Blanco Fernández de Valderrama, María José; Pérez, Raquel; Rabadán, M. Angeles; Aparicio, Marta; Resel, Eva; Martínez, Tamara; Nieto, M. Ángela
2004-01-01

Digital.CSIC (Spain)

24

Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation

Aznar Benitah, Salvador; Valerón, Pilar F.; Rincón, Sonia Victoria del; Fernández Pérez, Leandro; Perona Abellán, Rosario; Lacal Sanjuán, Juan Carlos
2001-10-01

Digital.CSIC (Spain)

26

Sex pheromone biosynthetic pathway for disparlure in the gypsy moth, Lymantria dispar

Jurenka, Russell A.; Subchev, Mitko; Abad, José Luis; Choi, Man-Yeon; Fabriàs, Gemma
2003-01-17

Digital.CSIC (Spain)

27

Sequence of nucleotides and peptides GSE 24.2 of dyskerin, which can induce telomerase activity, method for obtaining same, therapeutic compositions and applications thereof

Perona Abellán, Rosario; Machado Pinilla, Rosario; Sastre Garzón, Leandro; Sánchez Pérez, Isabel; Murguía Ibáñez, José Ramón
2010-06-15

Digital.CSIC (Spain)

28
29

S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology

Blanco, Francisco J; Grande, Maria T; Langa, Carmen; Oujo, Barbara; Velasco, Soraya; Rodriguez-Barbero, Alicia; Perez-Gomez, Eduardo; Quintanilla Ávila, Miguel; Lopez-Novoa, Jose M; Bernabeu, Carmelo
2008-12-05

Digital.CSIC (Spain)

30

Rme1 is Specific for Mi-1-Mediated Resistance and Acts Early in the Resistance Pathway

Martinez de Iladurya, O.; Nombela, G.; Feng-Hwang, CH-F; Williamson, V.; Muñiz, M.; Kaloshian, I.
2004-01-01

Digital.CSIC (Spain)

31

RhoA activation promotes transformation and loss of thyroid cell differentiation interfering with thyroid transcription factor-1 activity

Medina, Diego L.; Rivas, Marcos; Cruz, Patricia; Barroso, Isabel; Regadera, Javier; Santisteban, Pilar
2002-01-01

Digital.CSIC (Spain)

33

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

Radisky, Derek C.; Levy, Dinah D.; Littlepage, Laurie E.; Liu, Hong; Nelson, Celeste M.; Fata, Jimmie E.; Leake, Devin; Godden, Elizabeth L.; Albertson, Donna G.; Nieto, M. Ángela; Werb, Zena; Bissell, Mina J.
2005-07-07

Digital.CSIC (Spain)

35

Protooncogene-encoded protein kinases in interleukin-2 signal transduction

Reed, John C.; Torigoe, Toshihiko; Turner, Bruce C.; Mérida, Isabel; Gaulton, Glen; Saragovi, H. Uri; Rapp, Ulf R.; Taichman, Russell
1993-10-01

Digital.CSIC (Spain)

36

Proton-Conducting Polymers Based on Benzimidazoles and Sulfonated Benzimidazoles

Gómez-Romero, P.; Asensio, Juan Antonio; Borrós, Salvador
2002-07-04

Digital.CSIC (Spain)

39

Programmed cell death used as a biological containment system

Ayora, Silvia; Camacho, Ana; Saenger, Wolfram; Alonso, Juan Carlos
2004-01-15

Digital.CSIC (Spain)

41

Polarization of chemokine receptors to the leading edge during lymphocyte chemotaxis

Nieto, Marta; Frade, José M.R.; Sancho, David; Mellado, Mario; Martínez-Alonso, Carlos; Sánchez Madrid, Francisco
1997-07-01

Digital.CSIC (Spain)

42

Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family

Couceiro, José R.; Martín-Bermudo, María D.; Bustelo, Xosé R.
2005-08-15

Digital.CSIC (Spain)

43

Phosphorylation of the human-transforming-growth-factor-beta-binding protein endoglin

Lastres, Pedro; Jorge, MartÍn-Perez; Langa, Carmen; Bernabeu, Carmelo
1994-08-01

Digital.CSIC (Spain)

44

Peroxisomal Monodehydroascorbate Reductase. Genomic Clone Characterization and Functional Analysis under Environmental Stress Conditions

Leterrier, Marina; Corpas, Francisco J.; Barroso, Juan B.; Sandalio, Luisa M.; Río, Luis A. del
2005-08-01

Digital.CSIC (Spain)

45

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma

Govindarajan, Baskaran; Sligh, James E.; Vincent, Bethaney J.; Li, Meiling; Canter, Jeffrey A.; Nickoloff, Brian J.; Rodenburg, Richard J.; Smeitink, Jan A.; Oberley, Larry; Zhang, Yuping; Slingerland, Joyce; Arnold, Rebecca S.; Lambeth, J. David; Cohen, Cynthia; Hilenski, Lu; Griendling, Kathy; Martínez-Diez, Marta; Cuezva, José M.; Arbiser, Jack L.
2007-02-22

Digital.CSIC (Spain)

46

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma

Govindarajan, Baskaran; Sligh, James E.; Vincent, Bethaney J.; Li, Meiling; Canter, Jeffrey A.; Nickoloff, Brian J.; Rodenburg, Richard J.; Smeitink, Jan A.; Oberley, Larry; Zhang, Yuping; Slingerland, Joyce; Arnold, Rebecca S.; Lambeth, J. David; Cohen, Cynthia; Hilenski, Lu; Griendling, Kathy; Martínez-Diez, Marta; Cuezva, José M.; Arbiser, Jack L.
2007-02-22

Digital.CSIC (Spain)

47

Organogenic nodule formation from hop internodes. Reactive oxygen species and expression of lipoxygenase and extracellular-regulated kinases

Fortes, Ana M.; Sousa Silva, Marta; Costa, Joana; Coronado, María José; Sánchez-Testillano, Pilar; Risueño, María del Carmen; Pais, María S.
2005-05-31

Digital.CSIC (Spain)

49

Optimización de iones de fierro para la eliminación de piocianina en la reacción de degradación de Tolueno, Benceno y Fenol por Pseudomonas aeruginosa/ Optimization of iron ions to eliminate pyocyanine in the degradation reaction of Toluene, Benzene and Phenol by Pseudomonas aeruginosa

Rangel-García, María de L.; Rodríguez-Martínez, Jesús; Garza-García, Yolanda; Martínez-Hernández, José L.
2010-03-01

Resumen en español Una amplia gama de substancias xenobióticas representan un serio problema como contaminantes ambientales por su toxicidad; entre ellos los compuestos aromáticos pueden ser biodegradados por microorganismos que los usan como fuente de carbono y energía. El género Pseudomonas destaca por sus múltiples aplicaciones biotecnológicas debido a su gran versatilidad metabólica; puede producir metabolitos útiles, transformaciones enzimáticas, biodegradación y biorremediac (mas) ión de suelos, y en aguas contaminadas con petróleo y plaguicidas. En esta investigación se usaron células de P. aeruginosa para degradar tolueno, benceno y fenol. La cepa fue cultivada en medio mineral sólido y se establecieron las concentraciones óptimas para el desarrollo de células viables: 0.31, 0.19 y 0.13 M para tolueno, benceno y fenol. Los ambientes con concentraciones limitadas de Fe(III) favorecen la producción de piocianina, pigmento que puede interferir en el método analítico de biodegradación de compuestos aromáticos. Este efecto fue eliminado aumentando la concentración de iones de fierro en el medio. Con base en lo anterior, se optimizó y estableció el medio de cultivo mineral con 0.04 g L-1 de FeSO4 en presencia de tolueno (0.03 M) y con esta concentración inicial la tasa de biodegradación fue 75 %. Las pruebas de degradación específicas para los compuestos aromáticos mostraron que la cepa de P. aeruginosa usada puede degradar tolueno, benceno y fenol. Las tasas de degradación fueron mayores para tolueno (58.4 %) y benceno (70.11 %) con concentraciones iniciales de 0.14 M y 0.16 M, y la degradación fue menor para fenol (24.65 %) con una concentración inicial 0.10 M. La capacidad degradadora de P. aeruginosa tuvo proporción directa con su crecimiento en presencia de los xenobióticos estudiados, mostrando una mayor cantidad de proteína celular en los cultivos con benceno (1.4982 mg mL-1), tolueno (0.8629 mg mL-1) y menor en los cultivos desarrollados en presencia de fenol (0.4431 mg mL-1); lo cual muestra que un deficiente desarrollo bacteriano (biomasa) influye en una subóptima biodegradación. Resumen en inglés A wide range of xenobiotic substances represent a serious problem as environmental pollutants because of their toxicity, among them are found aromatic compounds that can be biodegraded by microorganisms, which use them as their source of carbon and energy. The genus Pseudomonas is outstanding for its multiple biotechnological applications due to its remarkable metabolic versatility. It is capable of producing useful metabolites, enzymatic transformations, biodegradation a (mas) nd bioremediation in soil, as well as in water polluted with oil and pesticides. In this study, cells of P. aeruginosa were used to degrade toluene, benzene and phenol. The strain was cultivated in a solid mineral medium, and the following optimal concentrations were established for the development of viable cells: 0.31, 0.19, and 0.13 M for toluene, benzene and phenol. The environments with limited concentrations of Fe(III) favored the production of pyocyanine, a pigment that can interfere in the analytical method of aromatic compound biodegradation. This effect was eliminated by increasing the concentration of iron ions in the medium. On this basis, the mineral culture medium was optimized and established at 0.04 g L-1 FeSO4 in presence of toluene (0.03 M). With this initial concentration, a rate of biodegradation of 75 % was obtained. The specific degradation tests for the aromatic compounds showed that the P. aeruginosa strain used can degrade toluene, benzene and phenol. The rates of degradation were higher for toluene (58.4 °/o) and benzene (70.11 °/o) with the initial concentrations of 0.14 M and 0.16 M. Degradation was less for phenol (24.65 %) with an initial concentration of 0.10 M. The degrading capacity of P. aeruginosa was directly proportional to its growth in the presence of the xenobiotic substances studied. A larger amount of cell protein was exhibited in cultures with benzene (1.4982 mg mL-1) and toluene (0.8629 mg mL-1), and less in the cultures grown in presence of phenol (0.4431 mg mL-1), indicating that deficient bacterial development (biomass) can result in suboptimal biodegradation.

Scientific Electronic Library Online (Spanish)

50

Nucleotide sequence that codes for a pseudomonas putida phaf protein.

Prieto Jimenez, María Auxiliadora; Moldes Tabares, Cristina; García González, Pedro Aurelio; García López, José Luis
2003-04-17

Digital.CSIC (Spain)

51

New metabolites in the degradation of fluorene by Arthrobacter sp. strain F101

Casellas, Mercè; Grifoll, Magdalena; Bayona Termens, Josep María; Solanas, Anna M.
1997-03-01

Digital.CSIC (Spain)

52

New downstream regulatory element antagonist modulator gene and polypeptide that is a transcriptional repressor, for identifying antitumor agents.

Naranjo, José Ramón; Mellström, Britt; Dompablo García, Isidro; Alexander Link, Wolfang; Carrión Rodríguez, Ángel Manuel; Ledo Gómez, Francisco
2002-07-01

Digital.CSIC (Spain)

55

Molecular Characterization of Spontaneous Mesenchymal Stem Cell Transformation

Rubio, Daniel; García, Silvia; Paz, María F.; Cueva, Teresa de la; López-Fernández, Luis A.; Lloyd, Alison C.; García-Castro, Javier; Bernad, Antonio
2008-01-02

Digital.CSIC (Spain)

56

Modulación de la estabilidad de la quinasa de receptores acoplados a proteínas G (GRK2) por la ligasa Mdm2

Mayor Menéndez, Federico; Penela Márquez, Petronila; Salcedo de Haro, Alicia
2007-01-01

Digital.CSIC (Spain)

57

Mobilization of storage reserves in the olive seed during in vitro germination

Zienkiewicz, Agnieszka; Zienkiewicz, Krzysztof; Jiménez-López, José Carlos; Alché Ramírez, Juan de Dios; Rodríguez García, María I.
2010-01-01

Digital.CSIC (Spain)

58

Method for genetically modifying woody plants by using cells with meristematic capacity

Burgos Ortiz, Lorenzo; Alburquerque, Nuria; Wang, Hong; Nortes Ruipérez, María Dolores; Piqueras, Abel; López Noguera, Sonia; Petri Serrano, César; Pérez Tornero, Olaya
2009-01-29

Digital.CSIC (Spain)

59

Metaplasia escamosa vesical, a propósito de un caso: Revisión de la literatura

Tramoyeres Galvañ, Alfredo; Canovas Ivorra, José Antonio; Sánchez Ballester, Francisco; la Torre Abril, Luis de; López Alcina, Emilio; Navalón Verdejo, Pedro; Zaragozá Orts, Julio
2005-02-01

Resumen en español OBJETIVO: Presentamos un nuevo caso de metaplasia escamosa por su interés y sutileza en el diagnóstico diferencial con otras patologías vesicales. MÉTODOS: El caso que presentamos se trata de un varón con antecedentes de otras neoplasias durante cuyo seguimiento aparece la sospecha de una lesión excrecente en la pared vesical. Tras realizarse RTU el diagnóstico histopatológico fue de metaplasia escamosa vesical. RESULTADOS: Se ha realizado un seguimiento mediante (mas) ecografía, cistoscopia y citología urinaria, con la frecuencia indicada en las guías clínicas dada la posibilidad de transformación en un carcinoma epidermoide. CONCLUSIONES: El urotelio es capaz de desarrollar transformaciones no neoplásicas como la metaplasia escamosa. La importancia de estas transformaciones radica en su correcto diagnóstico y su seguimiento, dada su capacidad de transformarse en un proceso neoplásico. Resumen en inglés OBJECTIVES: We report a new case of squamous metaplasia because of its interest and subtle differential diagnosis with other bladder pathologies. METHODS: We report the case of a male patient with history of previous neoplasia with an exophytic lesion of the bladder wall discovered on follow-up. Pathological diagnosis after TUR was bladder squamous metaplasia. RESULTS: Follow-up is performed by ultrasound, cystoscopy, and urine cytology in adherence to clinical guidelines (mas) due to the possibility of transformation into squamous cell carcinoma. CONCLUSIONS: Urothelium is able to develop non neoplastic transformations such as squamous metaplasia. The importance of such transformations depends on proper diagnosis and follow-up due to their ability to transform into a neoplastic process.

Scientific Electronic Library Online (Spanish)

60

Labdane diterpenes with a new oxidation pattern from the marine pulmonate Trimusculus peruvianus

Díaz-Marrero, Ana R.; Dorta, Enrique; Cueto, Mercedes; Rovirosa, Juana; San Martín, Aurelio; Loyola, Luis Alberto; Darias, José
2003-06-04

Digital.CSIC (Spain)

61

La apoptosis y la senescencia celular: mecanismos supresores de tumores/ Apoptosis and cellular senescence: tumor-suppressing mechanisms

Pardo Andreu, Gilberto; Hernández Casaña, Patricia; Delgado Hernández, René
2005-04-01

Resumen en español Los organismos con tejidos renovables tuvieron que evolucionar mecanismos que le permitieran prevenir el desarrollo de tumores. Entre esos mecanismos está la senescencia celular y la apoptosis o muerte celular programada. El primero impide de forma irreversible el crecimiento de células propensas a sufrir transformaciones neoplásicas; el segundo, mata células dañadas, que posean mutaciones y que puedan resultar peligrosas para el organismo. En trabajos recientes se h (mas) a demostrado cómo la pérdida de la apoptosis repercute en la iniciación del tumor, la progresión y el desarrollo de las metástasis. Por otra parte, se ha estudiado la complejidad del fenotipo senescente y su influencia sobre el organismo. Ambos mecanismos pudieran constituir ejemplos de pleiotropismo antagónico y la profundización en el balance que existe entre sus propiedades supresoras de tumores y sus aportes al fenotipo envejecido será esencial en el desarrollo de estrategias racionales para prevenir el cáncer y el proceso de envejecimiento. Resumen en inglés Organisms with renewable tissues had to evolve mechanisms that would allow them to prevent the development of tunors. Cellular senescence and apoptosis or programmed cell death are among those mechanisms. The first irreversibly prevents the growth of cells prone to suffer neoplastic transformations. The second kills damaged cells that have mutations and that may be dangerous for the organism. In recent papers it has been proved how the loss of the apotopsis has a repercus (mas) sion on the initiation of the tumor, the progression and the development of metastasis. On the other hand, the complexity of the senescent phenotype ant its influence on the organism has been studied. Both mechanisms could be examples of antagonistic pleiotropy and the deepening in the balance existing between its tumor- suppressing properties and its contributions to the aged phenotype will be esential in the development of rational strategies to prevent cancer and the aging process.

Scientific Electronic Library Online (Spanish)

62

LAS CÉLULAS MAMARIAS EN PROCESO DE DIFERENCIACIÓN DISMINUYEN SU VOLUMEN CITOPLASMÁTICO Y NUCLEAR

Cornejo U, Ricardo
2005-01-01

Resumen en español Las modificaciones experimentadas en el proceso biológico de diferenciación celular determinan cambios complejos y fundamentales en la ultraestructura, la bioquímica y la fisiología celular que pueden ser apreciadas claramente utilizando técnicas morfométricas, las cuales traducidas en información cuantitativa permiten evidenciar los cambios que conlleva este mecanismo. Células normales de epitelio mamario de rata, mantenidas en cultivo, estimuladas a proliferar c (mas) on el factor de crecimiento epidérmico, originan el grupo celular HC11 GM. Estas células normales y proliferantes son inducidas a diferenciarse mediante inducciones de hormonas lactogénicas: dexametasona, prolactina e insulina, determinándose la generación de un tipo celular diferenciado: HC11 IM. Estudiamos a nivel de microscopía electrónica estos tipos celulares, procurando datos morfométricos discriminantes a lo largo de la diferenciación, diagnosticando las fracciones volumétricas de componentes celulares, determinando así mismo la variación en el área de las células involucradas, precisando de este modo, nuevos marcadores en el padrón de modificación que caracteriza este proceso Resumen en inglés The changes suffered during the biological process on cell differentiation posses complex and fundamental changes in cell ultrastructure, biochemistry and physiology that can clearly be observed using morphometric techniques, wich, once translated on quantitative information, allow to evince the transformations sustained by this mechanism. Cultured normal rat epithelial breast cells, stimulated to proliferate by epidermic growth factor, give origen to HC11 GM cell group. (mas) These normal-proliferative cells are induced to differentiate by lactogenic hormones, like dexamethasone, prolactine and insuline, generating a differenciated cellular type: HC11 IM. Discriminating morphometric data of these cell types along of the differentiation process was obtained by electronic microscopy studies showing also variation on cell size though demostrating new markers on the modification pattern that characterizes this process

Scientific Electronic Library Online (Spanish)

63

Iron-Rich Diagenetic Minerals are Biomarkers of Microbial Activity in Antarctic Rocks

Wierzchos, Jacek; Ascaso, Carmen; García-Sancho, Leopoldo; Green, Allan
2003-01-01

Digital.CSIC (Spain)

64

In vivo assembling of bacterial ribosomal protein L11 into yeast ribosomes makes the particles sensitive to the prokaryotic specific antibiotic thiostrepton

García-Marcos, Alberto; Morreale de León, Antonio; Guarinos, Esther; Briones, Elisa; Remacha, Miguel; Ortíz, Ángel R.; Ballesta, Juan P.G.
2007-10-16

Digital.CSIC (Spain)

65

In vivo assembling of bacterial ribosomal protein L11 into yeast ribosomes makes the particles sensitive to the prokaryotic specific antibiotic thiostrepton

García-Marcos, Alberto; Morreale de León, Antonio; Guarinos, Esther; Briones, Elisa; Remacha, Miguel; Ortíz, Ángel R.; Ballesta, Juan P.G.
2007-10-16

Digital.CSIC (Spain)

66

Improving genetic transformation of European chestnut and cryopreservation of transgenic lines

Corredoira, Elena; San José, M.ª Carmen; Viéiztez, Ana M.; Ballester, Antonio
2007-12-01

Digital.CSIC (Spain)

67

Homothallic auxosporulation in Pseudo-nitzschia brasiliana (Bacillariophyta)1

Quijano Scheggia, Sonia I.; Garcés, Esther; Fortuño Alos, José Manuel; Camp, Jordi
2009-02-01

Digital.CSIC (Spain)

68

High incidence of c-K-ras oncogenes in human colon cancer detected by the RNAse A mismatch cleavage method

Forrester, K.; Almoguera, Concepción; Jordano, Juan; Grizzle, W.E.; Perucho, M.
1987-01-01

Digital.CSIC (Spain)

69

Heterologous Expression and Identification of the Genes Involved in Anaerobic Degradation of 1,3-Dihydroxybenzene (Resorcinol) in Azoarcus anaerobius

Darley, Paula I.; Hellstern, Jutta A.; Medina-Bellver, Javier I.; Marqués, Silvia; Schink, Bernhard; Philipp, Bodo
2007-05-01

Digital.CSIC (Spain)

70

Ha-ras interference with thyroid cell differentiation is associated with a down-regulation of thyroid transcription factor-1 phosphorylation

Velasco, Juan A.; Acebrón, Alvaro; Zannini, Mariastella; Martín-Pérez, Jorge; Di Lauro, Roberto; Santisteban, Pilar
1998-06-01

Digital.CSIC (Spain)

71

H-Ras Activation Promotes Cytoplasmic Accumulation and Phosphoinositide 3-Oh Kinase Association of β-Catenin in Epidermal Keratinocytes

Espada Regalado, Jesús; Pérez Moreno, Mirna Alicia; Braga, Vania M.M.; Pablo Rodriguez-Viciana; Cano García, Amparo
1999-09-06

Digital.CSIC (Spain)

72

Gene expression analysis of cold and freeze stress in baker's yeast

Rodríguez Vargas, Sonia; Estruch, Francisco; Rández Gil, Francisca
2002-06-01

Digital.CSIC (Spain)

73

Gene expression analysis in citrus reveals the role of gibberellins on photosynthesis and stress

Huerta, Laura; Forment, Javier; Gadea, José; Fagoaga, Carmen; Peña, Leandro; Pérez Amador, Miguel A.; García-Martínez, José Luis
2008-08-05

Digital.CSIC (Spain)

74

Fluidization of Membrane Lipids Enhances the Tolerance of Saccharomyces cerevisiae to Freezing and Salt Stress

Rodríguez Vargas, Sonia; Sánchez-García, Alicia; Martínez-Rivas, Jose Manuel; Prieto Alamán, José Antonio; Rández Gil, Francisca
2007-01-01

Digital.CSIC (Spain)

76

Expression of normal and truncated forms of human endoglin

Raab, Ulla; Velasco, Beatriz; Lastres, Pedro; Letamendía, Ainhoa; Calés Bourdet, Carmela; Langa, Carmen; Tapia, Esther; López-bote, Juan Pedro; Páez, Eduardo; Bernabeu, Carmelo
1999-05-01

Digital.CSIC (Spain)

77

Eukaryotic protein production in designed storage organelles

Torrent, Margarita; Llompart, Blanca; Lasserre-Ramassamy, Sabine; Llop-Tous, Immaculada; Bastida, Miriam; Marzabal, Pau; Westerholm-Pavinen, Ann; Saloheimo, Markku; Heifetz, Peter B.; Ludevid, M. Dolors
2009-01-28

Digital.CSIC (Spain)

78

Estudios sobre la localización y tráfico de los transportadores de las sinapsis glutamatérgicas SNAT2, SNAT5 y GLT1

Zafra Gómez, Francisco; Giménez Martín, Cecilio; González González, María Inmaculada
2007-01-01

Digital.CSIC (Spain)

79

Enzymes in the Synthesis of Bioactive Compounds: The Prodigious Decades

García-Junceda, Eduardo; García-García, Juan Francisco; Bastida, Ágatha; Fernández-Mayoralas, Alfonso
2004-04-15

Digital.CSIC (Spain)

80

Engineering and applications of fungal laccases for organic synthesis

Kunamneni, Adinarayana; Camarero, Susana; García-Burgos, Carlos; Plou, Francisco J.; Ballesteros, Antonio; Alcalde, Miguel
2008-01-01

Digital.CSIC (Spain)

81

Engineering and Applications of fungal laccases for organic synthesis

Kunamneni, Adinarayana; Camarero, Susana; García-Burgos, Carlos; Plou Gasca, Francisco José; Ballesteros, Antonio; Alcalde Galeote, Miguel
2008-11-20

Digital.CSIC (Spain)

85

Dpp Signaling Directs Cell Motility and Invasiveness during Epithelial Morphogenesis

Ninov, Nikolay; Menezes-Cabra, Sofia; Prat-Rojo, Carla; Manjón, Cristina; Weiss, A.; Pyrowolakis, George; Affolter, Markus; Martín-Blanco, Enrique
2010-03-23

Digital.CSIC (Spain)

86

Diterpenoid alkaloid derivatives as potential chemotherapeutic agents in American trypanosomiasis

González, Patricia; Marín, Clotilde; Rodríguez-González, Isabel; Illana, Antonio; Mateo, Héctor; Longoni, Silvia Stefánia; Rosales, María José; González-Coloma, Azucena; Reina, Matías; Sánchez Moreno, Manuel
2006-01-02

Digital.CSIC (Spain)

87

Distinct Utilization of Effectors and Biological Outcomes Resulting from Site-Specific Ras Activation: Ras Functions in Lipid Rafts and Golgi Complex Are Dispensable for Proliferation and Transformation

Calvo González, Fernando; Agudo-Ibáñez, Lorena; Crespo, Piero; Matallanas, David; Sanz-Moreno, Victoria; Arozarena, Imanol; Santos de Dios, Eugenio; Berciano, María T.
2006-01-01

Digital.CSIC (Spain)

88

Differential Role of Human Choline Kinase α and β Enzymes in Lipid Metabolism: Implications in Cancer Onset and Treatment

Gallego Ortega, David; Ramírez de Molina, Ana; Ramos, Maria Angeles; Valdés Mora, Fátima; Barderas, Maria Gonzalez; Sarmentero Estrada, Jacinto; Lacal Sanjuán, Juan Carlos
2009-11-12

Digital.CSIC (Spain)

91

Colonization process of olive tissues by Verticillium dahliae and its in planta interaction with the biocontrol root endophyte Pseudomonas fluorescens PICF7

Prieto Aranda, Pilar; Navarro-Raya, Carmen; Valverde-Corredor, Antonio; Amyotte, Stefan G.; Dobinson, Katherine F.; Mercado-Blanco, Jesús
2009-07-01

Digital.CSIC (Spain)

93

Centrosome and spindle pole microtubules are main targets of a fluorescent taxoid inducing cell death

Abal, Miguel; Souto, André A.; Amat-Guerri, Francisco; Acuña Fernandez, Alberto Ulises; Andreu, José Manuel; Barasoain, Isabel
2001-04-12

Digital.CSIC (Spain)

94

CD69 downregulates autoimmune reactivity through active transforming growth factor-β production in collagen-induced arthritis

Sancho, David; Gómez, Manuel; Viedma, Fernando; Esplugues, Enric; Gordón Alonso, Mónica; García López, María Ángeles; Fuente, Hortensia de la; Martínez-Alonso, Carlos; Lauzurica, Pilar; Sánchez Madrid, Francisco
2003-09-01

Digital.CSIC (Spain)

95

Biosynthesis of 10,12-dienoic fatty acids by a bifunctional Delta11 desaturase in Spodoptera littoralis

Serra, Montserrat; Piña, Benjamín; Bujons Vilàs, Jordi; Camps Díez, Francisco; Fabriàs, Gemma
2006-05-20

Digital.CSIC (Spain)

96
97

Assessment of the potential irritation and photoirritation of novel amino acid-based surfactants by in vitro methods as alternative to the animal tests

Benavides, Tomás; Martínez, Verónica; Mitjans, Montserrat; Infante, María Rosa; Morán, María del Carmen; Clapés Sabort, Pere; Clothier, Richard; Vinardell, M. Pilar
2004-05-21

Digital.CSIC (Spain)

98

Architecture singularities in flagged parallel manipulators

Borràs Sol, Julia; Thomas Arroyo, Federico; Torras Genís, Carme
2008-01-01

Digital.CSIC (Spain)

99

Anti-Tat and anti-HIV activities of trimers of n-alkylglycines

Márquez, Nieves; Sancho, Rocío; Macho, Antonio; Moure Fernández, Alejandra; Masip, Isabel; Messeguer Peypoch, Àngel; Muñoz, Eduardo
2006-02-28

Digital.CSIC (Spain)

103

A primitive hematopoietic cell is the target for the leukemic transformation in human philadelphia-positive acute lymphoblastic leukemia.

Cobaleda, C.; Gutiérrez-Cianca, N.; Flores, T.; García-Sanz, R.; González, M.; Sánchez-García, I.; Pérez-Losada, J.
2000-01-01

Digital.CSIC (Spain)

104

A constitutive shade-avoidance mutant implicates TIR-NBS-LRR proteins in Arabidopsis photomorphogenic development

Faigón Soverna, Ana; Harmon, Franklin G.; Storani, Leonardo; Karayekov, Elizabeth; Staneloni, Roberto J.; Gassmann, Walter; Más, Paloma; Casal, Jorge J.; Kay, Steve A.; Yanovsky, Marcelo J.
2006-11-17

Digital.CSIC (Spain)

105

A CMOS 0.8μm Transistor-Only 1.63MHz Switched-Current Bandpass ΣΔ Modulator for AM Signal A/D Conversion

Rosa Utrera, José Manuel de la; Pérez Verdú, Belén; Río Fernández, Rocío del; Rodríguez Vázquez, Angel
2000-08-01

Digital.CSIC (Spain)