Sample records for CALCIO 56 (calcium 56)
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1

Suplementación oral de calcio en adolescentes embarazadas/ Calcium oral supplementation in adolescent pregnant women

Herrera, Julián A; Arévalo-Herrera, Myriam; Villegas, Adriana; Herrera, Sócrates; Villalba, Maribel; Bromet, Arnoldo
2006-06-01

Resumen en español Objetivo: Determinar el efecto de la administración oral de calcio en adolescentes embarazadas de bajo nivel socioeconómico sobre las concentraciones de calcio ionizado plasmático y libre intracelular. Métodos: En un ensayo clínico controlado doble-ciego aleatorizado se estudiaron 52 mujeres, 26 (50%) adolescentes embarazadas que recibieron 600 mg de calcio elemental y 26 (50%) adolescentes embarazadas que recibieron 600 mg de placebo entre las semanas 17 y 19 de emb (mas) arazo. Los niveles pre-tratamiento y post-tratamiento de calcio ionizado plasmático y libre intracelular se evaluaron en ambos grupos de acuerdo con la intención de tratamiento. Resultados: Se analizaron 48 adolescentes embarazadas que completaron el estudio (24 en el grupo de calcio y 24 en el grupo de placebo). Las características sociodemográficas de los grupos fueron comparables (p=0.92) al igual que la ingesta basal de calcio en su dieta (p=0.62). La suplementación oral de calcio por intención de tratamiento no modificó las concentraciones de calcio ionizado plasmático (1.19+0.04 mmol/l vs. 1.23+0.02 mmol/l, p=0.56) ni las concentraciones del calcio ionizado libre intracelular (116.2 mmol/l vs. 89.7 mmol/l, p= 0.91), se observó un resultado semejante en las embarazadas que recibieron placebo (1.20+0.05 mmol/l vs. 1.19+0.03 mmol/l p=0.86; 116.2 mmol/l vs. 137.5 mmol/l, p=0.16, respectivamente). Conclusiones: La administración oral de calcio en adolescentes embarazadas de bajo nivel socioeconómico no modificó ni las concentraciones plasmáticas ni las intracelulares del calcio ionizado lo que podría explicar en parte el poco efecto preventivo del uso del calcio como única medida de intervención para prevenir la preeclampsia. Resumen en inglés Objective: To determine the effect of oral administration of calcium on plasma and ionized free calcium concentration in healthy adolescent pregnant women. Methods: In a double blind randomized controlled clinical trial were recruited 48 healthy adolescent pregnant women, 24 (50%) received 600 mg of elemental calcium and 24 (50%) received 600 mg of lactose placebo. At the inclusion time the plasma and intracellular free calcium concentrations were measured by standardized (mas) techniques. One month later the plasma and intracellular free calcium concentrations in both groups were measured. Results: At the inclusion time and one month after treatment both groups were comparable for sociodemographic characteristics and the basal intake of calcium (p=0.92, p=0.62). Calcium supplementation did not modify the concentrations of plasma ionized calcium (1.19+0.04 mmol/l vs. 1.23+0.02 mmol/l, p=0.56) and the free intracellular calcium concentration (mmol/l vs. 89.7 mmol/l, p=0.91); similar effects were observed with the placebo treatment (1.20+0.05 mmol/l vs. 1.19+0.03 mmol/l p=0.86; 116.2 mmol/l vs 137.5 mmol/l, p=0.16, respectively). Conclusions: Oral administration of 600 mg of elemental calcium in adolescent pregnant women did not induce changes in the plasma and intracellular ionized free calcium concentrations and could explain in part the lack effect of this only supplementation in preeclampsia prevention.

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2

Prevalencia de hipolactasia tipo adulto e intolerancia a la lactosa en adultos jóvenes

Ángel, Luis Alberto; Calvo, Enrique; Muñoz, Yesid
2005-12-01

Resumen en español OBJETIVOS. Determinar en adultos jóvenes la prevalencia de hipolactasia, la ingestión diaria de calcio y la presencia de síntomas de intolerancia a la lactosa. SUJETOS Y MÉTODOS. Estudio descriptivo transversal y analítico de prevalencia. Se escogieron al azar 98 estudiantes de la facultad de Medicina de la Universidad Nacional de Colombia y se estableció la frecuencia de hipolactasia (Test de hidrógeno), la ingestión diaria de calcio e intolerancia a la lactosa. (mas) RESULTADOS. El 56% de los participantes presentaron hipolactasia. La ingestión de calcio en hipolactásicos fue menor (-116 mg/día), asociada a menor ingestión de lácteos (-123 mg/día), sin diferencias en la frecuencia de intolerancia a la lactosa, que se presentó en el 14%. CONCLUSIONES. La prevalencia de hipolactasia es del 56%. La ingestión de calcio de origen lácteo es inferior en hipolactásicos no asociada a la prevalencia de intolerancia a la lactosa. La hipolactasia y baja ingestión de calcio son factores de riesgo de osteoporosis en esta población. Resumen en inglés AIMS. To establish in young adults the hypolactasia prevalence, calcium daily dietary ingestion and lactose intolerance symptoms frequency. SUBJECTS AND METHODS. Transversal descriptive prevalence and analytic study. Hypolactasia frequency in 98 Colombian National University randomized medical students was determined by Respiratory Hydrogen Test. Daily calcium ingestion and lactose intolerance was requested. RESULTS. Hipolactasia was present in 56% of students. In hypolac (mas) tasic subjects negatively calcium (-116 mg/d) and dairy (-123 mg/día) consumption were associated to. Lactose intolerance was present in 14% without consumption difference. CONCLUSIONS. Hypolactasia prevalence was 56%. Dairy calcium ingestion was Inferior in these subjects, not associated to lactose intolerance. Hypolactasia and low calcium ingestion are osteoporosis risk factors in this group.

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3

Consumo de fuentes de calcio en adolescentes mujeres en Panamá/ Food calcium intake in teenager women in Panama

Fernández-Ortega, Myriam
2008-09-01

Resumen en español Para conocer la adecuación de la ingesta de calcio y el consumo de bebidas carbonatadas en mujeres adolescentes en la Ciudad de Panamá, 180 estudiantes de sexo femenino de 12-17 años fueron entrevistadas en dos colegios públicos mediante un recordatorio de 24 horas y un formulario de frecuencia de consumo de alimentos. Según los resultados, la leche y el queso fueron las principales fuentes de calcio y los consumió el 60.5% y el 56.7% respectivamente; 1/4 del grupo (mas) consumió diariamente 1 porción de estos lácteos. Otras fuentes de calcio fueron el helado de crema y las leguminosas. El yogurt, refrescos y comidas con leche, hortalizas verdes, sardinas y alimentos fortificados no formaban parte de sus hábitos de alimentación. La ingesta promedio de calcio fue 440 mg/día ± 423 según la frecuencia de consumo y 314 mg/día ± 255 según el recordatorio de 24 horas. Ambos resultados son inferiores al 50% de la recomendación. El 72% del grupo consumió bebidas carbonatadas y la mayor parte (30%) tomaba una unidad diaria. Los lácteos fueron la principal fuente de calcio, pero la baja ingesta y el alto consumo de bebidas carbonatadas arriesgarían la futura salud ósea de estas adolescentes. Resumen en inglés The adequacy of calcium intake from food and carbonated drinks consumption levels in a Panama City’s female adolescents group was studied. We evaluated 180 teenage girls (12-17 years) in two public schools using food frequency questionnaires and a 24-hour food recall. According to the results, milk and cheese were this population’s main calcium source. Milk was a food source in 60.5%, while 56.7% indicated that they eat cheese. On average, a once-a-day intake of one of (mas) these dairy products was observed in 1/4 of the group. Ice cream and pulses were secondary calcium sources. Yogurt, milk-made meals and beverages, green vegetables, fortified food and sardines were not components of these girls’ food habits. The average calcium intake was 440 mg/d ± 423 according to the food frequency questionnaire and 314 mg/d ± 255 according to their 24-hour food recall. Calcium’s low level intakes are less than 50% of the recommended daily intake for this age group. Carbonated drinks were consumed by 72% of the group and 30% drank one unit daily. Dairy products are the main calcium source for the studied group. However, because of insufficient calcium intake and high consumption of carbonated drinks, the future bone health of these teenage girls is at risk.

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4

Marcadores bioquímicos óseos durante la premenopausia en mujeres con baja ingesta habitual de calcio/ Bone biochemical markers through premenopause in women with usual low calcium intake

Ponce, Graciela Mabel; Fajardo, María Angélica; Zeni, Susana Noemí; de Portela, María Luz
2005-03-01

Resumen en español Se evaluó el remodelamiento óseo en un grupo (GT) de mujeres premenopáusicas (n = 28) del sur argentino, clínicamente sanas, con densitometría normal de columna lumbar y cuello femoral, con predominio de baja ingesta de calcio habitual (ICa). La edad e índice de masa corporal fueron (promedio ± desviación estándar; mínimo-máximo): 33,2 ± 8,5 (22-49) años; 23,0 ± 2,8 (19-30) Kg/m2, respectivamente. La mediana y rangos de ICa, calculados en base a encuesta ali (mas) mentaria fueron: 568 (190-2.117) (mg/día). Con objeto de dilucidar el efecto de la suplementación cálcica, un subgrupo de 7 mujeres (GS), con ICa entre 429-664 mg/día, recibió 800 mg/día de calcio (citrato de calcio), bajo supervisión médica. Se determinaron inicialmente (To) en GT y a los 4 meses (Tf) en GS: crosslaps (CTX) y fosfatasa alcalina ósea (FAO), en suero; calcio (Ca), creatinina (Crea) y deoxipiridinolina (Dpir), en orina de 24 horas. Los resultados fueron: mediana (máximo-mínimo): a To, en GT y GS, respectivamente: Ca/crea (mg/mg): 0,110 (0,014-0,372); 0,089 (0,051-0,181); Dpir/crea (nM/mM): 5,2 (3,4-10,3); 5,2 (3,6-10,3); CTX (nM): 2,25 (0,30-6,20); 2,25 (1,49-5,20); FAO (UI/L): 58 (52-64); 58 (56-62). A Tf sólo CTX disminuyó significativamente: 1,16 (0,92-2,5) (p = 0,0175), indicando la capacidad de discernir cambios en el remodelamiento óseo y evidenciar los efectos benéficos de la suplementación. Resumen en inglés Bone markers were studied in 28 healthy premenopausal women (GT), living in Comodoro Rivadavia (Argentina), aged 33.2 ± 8.5 years (22-49), with normal femoral neck and lumbar spine (L2-L4) bone mineral density. Usual daily calcium intake (CaI), presented a median value and ranges of 568 (190-2.117) (mg/day). A subgroup of 7 women (GS) whith CaI lower than 700 mg/day received 800 mg/day of Ca (Ca citrate) during 4 months, under medical supervision. Fasting blood samples a (mas) nd 24 hs urine were collected at the beginning (To) in GT and after the supplementation period (Tf) in GS. Laboratory determinations were: calcium (Ca), creatinine (Crea) and deoxypiridinoline (Dpyr) (Pyrilinks, MetraBiosystems), in urine; crosslaps (CTX) (ELISA, Osteometer, BioTech) and bone alkaline phosphatase (BAPh) (after a selective precipitation with wheat-germ-lectine), in serum. The bone markers in GT and GS, at To, presented the following median values and ranges (between brackets), respectively: Ca/crea (mg/mg): 0.110 (0.014-0.372); 0.089 (0.051-0.181); Dpir/crea (nM/mM): 5.2 (3.4-10.3); 5.2 (3.6-10.3); CTX (nM): 2.25 (0.30-6.20); 2.25 (1.49-5.20); BAPh (UI/L): 58 (52-64); 58 (56-62). CTX was the only marker that at Tf showed a significant decrease (p = 0.0175), suggesting its usefulness and sensibility to evidence the benefits of Ca supplementation to achieve a decrease in bone resorption.

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5

Exportación de nitrógeno y calcio mediante raleo en un rodal de Eucalyptus nitens de 5 años de edad, Chile/ Export of nitrogen and calcium through the thinning of a five-year-old stand of Eucalyptus nitens, Chile

Thiers E, Oscar; Gerdinga, Victor; Schlatter, Juan E
2007-01-01

Resumen en español El objetivo del presente trabajo fue evaluar la exportación de nitrógeno y calcio en un rodal de Eucalyptus nitens de 5 años de edad (41º01' S y 73°27' O; 200 m de elevación, suelo rojo arcilloso Acrudoxic Hydric Hapludand), con y sin fertilización, producto de raleo con diferentes grados de extracción de biomasa (fuste, tronco y árbol completo). La plantación se estableció en 1996 y se fertilizó (F) con roca fosfórica antes de plantar, en la primavera del mi (mas) smo año (NPK + microelementos), al año siguiente (NPK) y al tercer año (NP). Una superficie semejante (0,25 ha) fue definida como testigo (T). Se consideró el raleo de 700 árboles ha-1, dejando una densidad residual de 800 árboles ha-1 con poda del tercio inferior de la copa. Previo al raleo la biomasa aérea en T fue de 95,6 Mg ha-1 (acumulación de: 434 kg N ha-1 y 306 kg Ca ha-1) y en F de 121,3 Mg ha-1 (516 kg N ha-1 y 359 kg Ca ha-1). Las raíces representaron 6,2% y 5,4% de la biomasa total, respectivamente. La extracción del fuste (sólo madera) exportó 16-18% del nitrógeno y 5-6% de calcio aéreo del rodal, mientras que la extracción del árbol completo extrajo 41-44% del nitrógeno y del calcio. La corteza fue el componente de biomasa que más calcio acumuló, alcanzando a casi el triple que en la madera. La retención de la corteza en el sitio puede ser significativa para el abastecimiento de este elemento durante la rotación Resumen en inglés The aim of the present paper was to assess the export of nitrogen and calcium in a five-year-old stand of Eucalyptus nitens (41°01'S y 73°27' W; 200 m rise, Acrudoxic Hydric Hapludand red clay soil), with and without fertilization, due to the thinning with varying extents of biomass extraction (logs: only wood, trunks: wood plus bark, and whole tree). The plantation was established in 1996 and was fertilized (F) with phosphoric rock before planting, in the spring of the (mas) same year (NPK + microelements), the next year (NPK) and the third year (NP). A similar surface (0.25 ha) was defined as the control plot (T). The thinning of 700 trees ha-1 was considered, leaving a residual density of 800 trees ha-1 with the pruning of the lowest third of the crown. Prior to the thinning, the above-ground biomass in T was 95.6 Mg ha-1 (accumulation of: 434 kg N ha-1 and 306 kg Ca ha-1) and in F it was 121.3 Mg ha-1 (516 kg N ha-1 and 359 kg Ca ha-1). Roots represented 6.2% and 5.4% of the total biomass, respectively. The extraction of logs (only wood) exported 16-18% of the above-ground nitrogen and 5-6% of the above-ground calcium in the stand, whereas the extraction of whole trees took out 41-44% of the nitrogen and calcium. The bark was the biomass component that accumulated the most calcium, reaching almost three times as much as that in the wood. Retention of the bark in the site can be significant for the supply of this element during rotation

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6

Consumo de fibra dietética, sodio, potasio y calcio y su relación con la presión arterial en hombres adultos normotensos/ Dietary fiber, energy, sodium, potassium and calcium intake and its relationship to blood pressure in normotensive male adults

Ballesteros-Vásquez, Martha Nydia; Cabrera-Pacheco, Rosa María; Saucedo-Tamayo, María del Socorro; Grijalva-Haro, María Isabel
1998-05-01

Resumen en español Objetivo. Evaluar el efecto del consumo de fibra dietética, energía, sodio, potasio y calcio sobre la presión arterial de un grupo de adultos normotensos, tomando en cuenta indicadores tales como la edad, el sexo, la actividad física y la obesidad. Material y métodos. Se evaluaron 38 sujetos del sexo masculino de 30 a 45 años de edad, normotensos, aparentemente sanos y residentes de la ciudad de Hermosillo, Sonora, México. Se midió la presión arterial y se realiz (mas) ó una evaluación dietética, antropométrica y de actividad física. Resultados. La dieta resultó ser alta en fibra y en grasa. El sodio estaba 56% por arriba de la recomendación en 87% de los casos y fue la variable que más efecto mostró sobre la presión diastólica. De los sujetos estudiados, 36.9% tenían sobrepeso y obesidad, y se encontró una asociación significativa entre el índice de masa corporal y la presión diastólica y sistólica. Conclusiones. Existe una asociación significativa entre la hipertensión arterial y el alto consumo de sodio, el sobrepeso y la obesidad en sujetos normotensos. Resumen en inglés Objective. To evaluate the effect of dietary fiber, energy, sodium, calcium and potassium intake on the blood pressure of a group of normotensive adults. Material and methods. Subjects were 38 healthy normotensive adult males aged 30-45 years, resident of Hermosillo, Sonora, Mexico. Blood pressure, diet, anthropometric data and physical activity were recorded. Results. Their diet was high in fiber and fat. Sodium intake was 56% above the recommended values in 87% of the s (mas) ubjects, and the variable with the highest correlation to diastolic blood pressure. Of the subjects, 36.9% were overweight and obese, and a significant statistic association was found between BMI and diastolic and systolic blood pressure. Conclusions. A significant relationship was found between hypertension and high consumption of sodium, overweight and obesity in healthy adult normotensive males.

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7

Consumo de energía y nutrimentos en mujeres mexicanas en edad reproductiva/ Energy and nutrient intake in mexican women of reproductive age

FLORES, MARIO; MELGAR, HUGO; CORTÉS, CECILIA; RIVERA, MARTA; RIVERA, JUAN; SEPÚLVEDA, JAIME
1998-03-01

Resumen en español Objetivo. Analizar el consumo de energía y nutrimentos de mujeres mexicanas de 12 a 49 años de edad. Material y métodos. La información dietética se obtuvo por recordatorio de 24 horas en 9 101 mujeres participantes en la Encuesta Nacional de Nutrición de 1988 y se contrastó con características sociodemográficas y estado fisiológico. El consumo de nutrimentos se comparó con las recomendaciones de ingestión dietética (RID). Resultados. La mediana del consumo e (mas) nergético fue de 1 568 kcal/día. La dieta estuvo conformada por 15% de proteína, 60% de hidratos de carbono y 25% de grasa. La proporción de mujeres con una ingestión inferior a la mitad de las RID fue de 70% para vitamina A, 75% para B6, 56% para vitamina C, 33% para B12, 69% para folato, 33% para calcio y 22% para hierro. Conclusiones. Los hallazgos muestran deficiencias importantes en la dieta, las cuales son más acentuadas en mujeres embarazadas o nodrizas, en las de menor nivel socioeconómico, en las que habitan en áreas predominantemente rurales o indígenas y en las de la región sur. Resumen en inglés Objective. To analyze energy and nutrient consumption in Mexican women from 12 to 49 years of age. Material and methods. Dietetic information was gathered by a 24 h recall from 9 101 women who participated in the National Nutrition Survey conducted in 1988. These data were compared with sociodemographic and physiologic characteristics. Nutrient consumption was compared with the Recommended Daily Allowances (RDA). Variance analysis and t-test were used to evaluate group di (mas) fferences. Results. Mean energy consumption was 1 721 kcal per day. The diet consisted of 15% protein, 60% carbohydrates and 25% fat. The proportion of women with dietary intakes lower than 50% of the RDA was 70% for vitamin A, 75% for vitamin B6, 56% for vitamin C, 33% for vitamin B12, 69% for folate, 33% for calcium and 22% for iron. Conclusion. Results show important deficiencies in the diet, predominantly in pregnant and lactating women, in women from low socioeconomic levels and in rural and indigenous women of south of the Mexican republic.

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8

Indicadores metabólicos en razas lecheras especializadas en condiciones tropicales en Colombia/ Metabolic profile in dairy cows under tropical conditions in Colombia

Campos G, Rómulo; Cubillos, Carolina; Rodas, Ángela G
2007-06-01

Resumen en español Se ha seleccionado un alto número de razas bovinas para producción de leche, sin embargo, las de origen Bos taurus no han logrado adaptarse a las condiciones tropicales. El objetivo del trabajo fue analizar el comportamiento metabólico de siete razas (Ayrshire, Girolando, Holstein Friesian, Jersey, Lucerna, Pardo Suizo y Simenthal) a través de 15 metabolitos. Se emplearon 28 animales por raza, distribuidos en cuatro grupos fisiológicos: novillas, inicio y final de la (mas) ctancia y vacas secas (final de gestación). Los valores medios de los indicadores metabólicos fueron: BOH 0.5 mmol/l; glucosa 2.8 mmol/l; colesterol 2.5 mmol/l; potasio 4.1 mmol/l; calcio 2.0 mmol/l; fósforo inorgánico 1.7 mmol/l; magnesio 1.1 mmol/l; proteínas totales 66.2 mg/dl; albúmina 25.8 mg/dl; globulinas 40.2 mg/dl; creatinina 109 µmol/l; BUN 3.8 mmol/l; ALT 32.2 UI/l; AST 56.6 UI/l; GGT 12.3 UI/l; bilirrubina total 0.2 µmol/l; bilirrubina conjugada 0.08 µmol/l. Los valores medios de la condición corporal y el hematocrito fueron 3.25% y 27.0% respectivamente. Se encontraron diferencias estadísticas significativas entre grupos raciales y entre grupos de producción. Los animales de menor peso metabólico (Jersey) presentaron mejor homeostasis que los de pesos mayores (Simenthal, Holstein). Resumen en inglés High numbers of bovine breeds have been selected as milk producers, but those derived from the Bos taurus breeds have been unable to adapt to tropical conditions. The aim of this work was to analyze the metabolic profile of the seven breeds (Ayrshire, Girolando, Holstein Friesian, Jersey , Lucerna, Brown Swiss and Simmental) through the use of 15 metabolites. For each breed, 28 animals were used, divided into four physiological different groups: heifers, cows from the fir (mas) st stages and last stages of the lactation process and dry cows. The mean values of metabolites indicators were as follow: BOH 0.5 mmol/l; glucose 2.8 mmol/l; cholesterol 2.5 mmol/l; potassium 4.1 mmol/l; calcium 2.0 mmol/l; inorganic phosphorus 1.7 mmol/l; magnesium 1.1 mmol/l; total protein 66.2 mg/dl; albumin 25.8 mg/dl; globulin 40.2 mg/dl; creatinine 109 µmol/l; BUN 3.8 mmol/l; ALT 32.2 UI/l; AST 56.6 UI/l; GGT 12.3 UI/l; total bilirubin 0.2 µmol/L; conjugate bilirubin Additionally, body condition and PCV were determined with average values of 3.25 and 27% respectively. A significant statistical difference was found among breeding groups and physiological groups for production. It was observed that those animals with a low metabolic weight (Jersey) demonstrate better homeostasis than those of high metabolic weight (Simmental, Holstein ).

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9

Absorción de formas de nitrógeno amoniacal y nítrica por plantas de papa en la producción de tubérculo-semilla/ N-nh4+ and n-no3 uptake by potato in the tuber seed production/ Absorção de formas de nitrogênio amoniacal e nitrica pela batateira na produção de tubérculo-semente

Coraspe-León, Héctor M; Muraoka, Takashi; Ide Franzini, Vinicius; Contreras Espinal, Freddy S; Ocheuze Trivelin, Paulo C
2009-03-01

Resumen en portugués O N é constituinte estrutural de proteínas, de muitos metabólitos envolvidos na síntese e transferência de energia e mesmo de ácidos nucléicos. O nitrogênio pode ser absorvido pelas plantas na forma de nitrato (NO3-) ou amônio (NH4+). A absorção de nitrato varia conforme a cultivar e intensidade luminosa como pode ser constatado em diversas culturas. O objetivo deste trabalho foi deter­minar a forma de N (N-NH4+ ou N-NO3-) mais absorvida pelas plantas de batat (mas) a na produção de tubérculos-semente, usando o isótopo 15N. O experimento foi realizado em condições de casa-de-vegetação durante os meses de agosto a novembro de 2006 nas instalações do Centro de Energia Nuclear na Agricultura (CENA), Universidade de São Paulo (USP), Brasil. Foi desenvolvido em vasos plásticos de 2,3 l de capacidade usando como substrato argila expandida. O delineamento experimental empregado foi o de blocos completos ao acaso com cinco tratamentos, referentes às épocas de aplicação do NH4NO3 marcado: 14, 28, 42, 56 e 70 DAT, e três repetições. Foi usada a solução nutritiva IAC, modificada quanto ao fornecimento de N, K e Ca, substituindo-se o nitrato de cálcio e nitrato de potássio pelo nitrato de amônio enriquecido com 15N. Para determinar a eficiência de utilização do N do nitrato de amônio das plantas de papa marcadas com 15N, baseou­se no princípio da diluição isotópica, considerando-se o enriquecimento em % de átomos de 15N, a quantidade de 15N na planta e descontando-se a variação natural do isótopo estável 15N. A forma preferencial de absorção do nitrogênio no estádio inicial de desenvolvimento foi a amoniacal, tornando-se a nítrica após 56 dias (formação de tubérculos). O aproveitamento de N pelas plantas, porém, foi sempre maior com a forma amoniacal aplicada em todos os estádios, com exceção aos 28 dias e no final do ciclo. Resumen en español El objetivo de este trabajo fue determinar la forma de N (N-NH4+ o N-NO3-) más absorbida por las plantas de papa en la producción de tubérculos-semilla, usando el isótopo 15N. El experimento fue realizado en condiciones de inver­nadero durante los meses de agosto a noviembre de 2006 en las instalaciones del Centro de Energía Nuclear en la Agricultura (CENA), Universidad de São Paulo (USP), Brasil. Fue conducido en potes plásticos de 2,3 l de capa­cidad usando com (mas) o sustrato arcilla expandida. El diseño experimental empleado fue el de bloques completos al azar con 5 tratamientos, referentes a las épocas de aplicación del NH4NO3 marcado: 14, 28, 42, 56 e 70 DDT, y 3 repeti­ciones. Fue usada la solución nutritiva IAC, modificada en cuanto al suministro de N, K y Ca, sustituyéndose el nitrato de calcio y nitrato de potasio por el nitrato de amonio enriquecido con 15N. Para determinar la eficiencia de utili­zación del N del nitrato de amonio de las plantas de papa marcadas con 15N, se consideró el principio de la dilución isotópica, considerándose el enriquecimiento en % de átomos de 15N, la cantidad de 15N en la planta y descon­tándose la variación natural del isótopo estable 15N. La forma preferencial de absorción del nitrógeno en la fase inicial de desarrollo fue la amoniacal, tornándose a nítrica después de 56 días (formación de tubérculos). El aprove­chamiento de N por las plantas, sin embargo, fue siempre mayor con la forma amoniacal aplicada en todos los estadios, con excepción de los 28 días y al final de ciclo. Resumen en inglés The nitrogen is the structural constituent of proteins, several metabolites involved in the synthesis and trans­ference of energy and also of nucleic acids. It is absorbed by plants in the nitrate (NO3-) or ammonium (NH4+) form. The nitrate uptake varies with cultivar and light intensity. The objective of this research was to determine the preferential form of N (N-NH4+ or N-NO3-) absorbed by the potato plants in seed tuber productions, using 15N isotope. The experiment (mas) was carried out in the greenhouse of Centro de Energia Nuclear na Agricultura (CENA) / USP, Brazil, using 2.3 l plastic pots, with expanded clays as substrate. The experimental design used was a completely randomized with five treatments, corresponding to the labeled NH4 or NO3 (15NH4 or 15 NO3) application time: 14, 28, 42, 56 and 70 days after transplanting (DAT), and three replicates. An IAC nutrient solution was used, modified to supply N, K and Ca, substituting calcium nitrate and potassium nitrate by ammonium nitrate labeled with 15N. The preferential form of nitrogen absorption at the initial developing stage was the ammonium, changing to nitrate after 56 DAT (tuber formation). The N utilization by the plants, however, was always higher with ammonium form applied in all stages, with the exception at 28 DAT and at the end of cycle.

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Preparación intestinal para colonoscopia; comparación entre polietilenglicol y manitol: Estudio de costo efectividad, doble ciego aleatorizado

Forero, Elías; Cardona, Héctor; Reyes, Gustavo; Abello, Hasan; Rosas, Martha; Sánchez, Carlos
2005-12-01

Resumen en español OBJETIVO. Comparar la eficacia, seguridad y adherencia del manitol y polietilenglicol para la preparación intestinal de colonoscopias diagnósticas. ESTUDIO. Clínico Controlado Aleatorizado Doble Ciego. SET. Unidad de Gastroenterología Hospital Central de la Policía. PARTICIPANTES. 297 sujetos fueron incluidos, 142 al grupo A (polietilenglicol) y 155 al grupo B (Manitol). INTERVENCIÓN. Preparación con 4 litros de solución de Polietilenglicol en el grupo A, preparac (mas) ión con 500 ml de Manitol al 20% más Bisacodilo 20 mgs en el Grupo B. PRINCIPALES RESULTADOS MEDIDOS. Evaluación cualitativa y cuantitativa de la calidad de preparación en colon proximal y distal según la escala de Vanner, proporción de colonoscopia total, incidencia de eventos adversos, proporción de sujetos que completaron los protocolos, efecto sobre los niveles séricos de sodio, potasio, cloro y calcio. RESULTADOS. Los grupos fueron comparables en edad y sexo (p > 0,05), todos los sujetos admitidos fueron incluidos en el análisis: No se encontró diferencia en los grupos al evaluar proporción de colonoscopia completa (A) 92,9%, (B) 90%, (IC 95% 0,96-1,09); preparación excelente o buena (A) 86,6%, (B) 91,6% (IC 95% 0,87-1,02); frecuencia de eventos adversos no serios (A) 20,5%, (B) 23,9% (IC 95% 0,56-1,31); no se encontró diferencia sobre electrolitos séricos. CONCLUSIONES. La preparación intestinal para colonoscopia diagnóstica con manitol o polietilenglicol proporcionan resultados de limpieza colónica semejante, siendo medicamentos seguros, confiables y bien tolerados, el manitol, con un costo significativamente menor que el de polietilenglicol, lo constituye en la alternativa de primera elección para colonoscopia diagnóstica. Resumen en inglés OBJECTIVE. To compare the effectiveness, security and adherence of the manitol and polietilenglicol for the intestinal preparation of diagnostic colonoscopy. STUDY. Clinical Controlled Randomized Double Blind. SET. Unit of Gastroenterology of Central Hospital of the Police. PARTICIPANTS. 297 patients were included, 142 to the group A (polietilenglicol) and 155 to the group B (Manitol). INTERVENTION. Preparation with 4 liters of solution of Polietilenglicol in the group A, (mas) preparation with 500 ml of Manitol 20% and Bisacodilo 20 mgs in the Group B. MAIN MEASURED RESULTS. Qualitative and quantitative evaluation of the preparation quality in colon proximal and distal according to the Vanner scale, proportion of total colonoscopy, incidence of adverse events, and proportion of fellows that completed the protocols, effect on the levels séricos of sodium, potassium, chlorine and calcium. RESULTS. The groups were comparable in age and sex (p> 0,05), all the admitted fellows were included in the analysis: They was not difference in the groups when evaluating proportion of complete colonoscopia (A) 92.9%, (B) 90%, (IC 95% 0.96-1.09); excellent or good Preparation (A) 86.6%, (B) 91.6% (IC 95% 0.87-1.02); frequency of adverse events not serious (A) 20.5%, (B) 23.9% (IC 95% 0.56-1.31); They was not difference it has more than enough electrolytes serics. CONCLUSIONS. The intestinal preparation for diagnostic colonoscopy with manitol or polietilenglicol provides results of similar colonic cleaning, being sure, reliable and well tolerated medications, the manitol with a significantly smaller cost that of polietilenglicol constitutes it in the first election for diagnostic colonoscopy.

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Valores bioquímicos sanguíneos de equinos que tiran carretones en la ciudad de Valdivia (Chile)

TADICH, N.; MENDEZ, G.; WITTWER, F.; MEYER, K.
1997-01-01

Resumen en español Este estudio se llevó a cabo para establecer las concentraciones sanguíneas promedio de glucosa, ácido láctico, b-hidroxibutirato (b-HBA), urea, creatininquinasa (CK), aspartato aminotransferasa (AST), calcio (Ca), fósforo inorgánico (Pi) y magnesio (Mg) en equinos que tiran carretones en la ciudad de Valdivia, con el objeto de determinar el grado de adecuación de estos animales al trabajo que realizan y su relación con la edad, sexo y sus cargas parasitarias (h.p (mas) .g.). Sesenta muestras de suero y plasma fueron obtenidas de caballos castrados y yeguas no gestantes clínicamente sanos, entre 3 y 20 años de edad. Antes de obtener las muestras los animales se dejaron descansar, por al menos 30 minutos, antes de ser sometidos a un examen clínico general. Se registraron el nombre y dirección del propietario y la raza, sexo, edad y peso del animal. Después del examen, se obtuvieron dos muestras de sangre por punción yugular utilizando tubos al vacío con NaF y sin anticoagulante. Las muestras obtenidas fueron llevadas al laboratorio, procesadas y almacenadas a -20°C para su posterior análisis. Las concentraciones sanguíneas promedio de los componentes bioquímicos estudiados fueron 7.31 ± 1.46 mmol/l para urea, 0.15 ± 0.09 mmol/l para b-HBA, 4.62 ± 0.55 mmol/l para glucosa, 2.55 ± 0.92 mmol/l para lactato, 179.74 ± 85.81 U/l para CK, 390.27 ± 148.56 para AST, 2.74 ± 0.17 mmol/l para Ca, 1.03 ± 0.25 mmol/l para Pi y 0.7 ± 0.07 mmol/l para Mg. No se encontraron diferencias significativas (p 0.05) al comparar las concentraciones sanguíneas promedio de los componentes medidos entre caballos y yeguas, entre diferentes categorías de edad (2-6 años, 7-11 años y 12 o mayores de 12 años) y entre animales con diferentes cargas parasitarias. Se concluyó que los equinos que tiran carretones en la ciudad de Valdivia presentaron concentraciones plasmáticas promedio de ácido láctico, b-HBA y actividad sérica de CK por sobre los valores de referencia establecidos para la especie, sugiriendo una falta de adecuación al trabajo que realizan. Los otros componentes analizados estuvieron dentro de los rangos establecidos para la especie. No existió una correlación significativa (p 0.05) entre los valores sanguíneos de los componentes analizados y la edad y sexo de los animales Resumen en inglés This study was carried out in order to establish glucose, lactic acid, b-hidroxibutirate (b-HBA), urea, creatininkinase (CK), aspartate aminotransferase (AST), calcium (Ca), inorganic phosphorus (Pi) and magnesium (Mg) blood concentrations in loadcart draught horses in Valdivia, Chile, and the degree of adaptation of these animals to the exercise performed. Also, the relationship of these concentrations with the sex, age a (mas) nd parasite egg counts of the horses were determined. Sixty serum and plasma samples obtained from clinically healthy, 3 to 20 years old, crossbred geldings and non pregnant mares, were used. Before taking samples, the animals were left to rest for at least 30 minutes, and then subjected to a general clinical examination; name and address of the owner, race, sex, age and weight of the horses were recorded. After the examination, two blood samples were obtained by yugular venopuncture, using plain tubes and tubes with NaF. Blood mean concentrations were 7.31 ± 1.46 mmol/l, for urea; 0.15 ± 0.09 mmol/l, b-HBA; 4.62 ± 0.55 mmol/l, glucose; 2.55 ± 0.92 mmol/l, lactate; 179.74 ± 85.81 U/1, CH; 390.27 ± 148.56 U/1, AST; 2.74 ± 0.17 mmol/l, Ca; 1.03 ± 0.25 mmol/l, Pi and 0.70 ± 0.07 mmol/1 for Mg. No significant differences (p 0.05) were found when blood concentrations of the biochemical parameters analyzed were compared according to age, sex and parasite egg counts of the animals. It was concluded that loadcart draught horses in Valdivia present mean blood concentrations of plasmatic lactic acid, serum b-HBA and serum activity of CK above the ranges of reference established for the species, suggesting that they are not well adapted to the work they perform. Blood concentrations of the different biochemical parameters analyzed showed no significant correlation (p 0.05) with the sex and age of the horses

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Nutrición mineral en sistemas ganaderos de las sabanas centrales de Venezuela/ Mineral nutrition in cattle production systems in central savannas of Venezuela

Depablos, Luis; Godoy, Susmira; Chicco, Claudio F; Ordoñez, Jorge
2009-01-01

Resumen en español Para evaluar el estado de la nutrición mineral en sistemas ganaderos de los llanos centrales de Venezuela en sabanas bien (SBD) y mal (SMD) drenadas e intermedias (SI), se seleccionaron unidades de producción del municipio El Pao de San Juan Bautista del estado Cojedes, Venezuela, en una zona de vida de bosque seco tropical. Se tomaron muestras de suelo, forraje, suero sanguíneo, hueso e hígado de bovinos para análisis mineral. En el suelo el contenido de materia org (mas) ánica (2,5%) fue moderado y el pH ligeramente ácido (6,0). Los cationes Ca, K y Mg estuvieron por encima del nivel crítico para la producción de forrajes. El contenido de P (ppm) fue adecuado para SMD (12,5), ligeramente inferior para SI (9,0) y deficiente para SBD (6,8). En el forraje, el P fue adecuado (0,26 y 0,21% para SMD y SI, respectivamente) y bajo (0,12%) para SBD. El Ca fue mayor en SMD (0,56%), seguido por SI (0,39%) y SBD (0,26%). El contenido de Mg, K, Na y Cu en forraje fue superior a los niveles críticos para la producción con bovinos, mientras que el Fe y Mn fueron altos. En suero sanguíneo, el P fue bajo, con mayores niveles en animales jóvenes (4,16; 3,44; 3,34 mg/dL para mauta, novilla y vaca, respectivamente). En tejido hepático, el Cu (98 ppm), Zn (129 ppm) y Mn (9,7 ppm) se encontraron en niveles adecuados, mientras que el Fe (287 ppm) fue alto, guardando relación con el contenido en sangre y forraje. En el hueso, la concentración de Ca (21,7%; 243 mg/cm3) y P (9,9%; 106 mg/cm3) fueron deficientes. Se concluye que hay deficiencias de P en el sistema suelo-planta-animal, eventuales de Ca en algunos componentes del sistema (suero sanguíneo, hueso y forrajes) y elevadas concentraciones de Fe, Mn y Zn que pueden ocasionar relaciones antagónicas. Resumen en inglés To evaluate mineral nutrition in cattle production systems in the central plains of Venezuela, in well drained (WDS) and poorly drained (PDS) savannas as well as intermediate savannas (IS), nine cattle production units were selected in the municipal district of Pao de San Juan Bautista of Cojedes state, Venezuela, corresponding to a dry tropical forest. Soil, forage, animal blood serum, bone and liver samples were taken for chemical analysis. Ca, K, and Mg cations were hi (mas) gher than the critical levels required for forage production. Phosphorus content (ppm) was adequate in PDS (12.5), slightly lower in IS (9.0), and deficient in WDS (6.8). In forage, P was found to be adequate with values of 0.26 and 0.21% for PDS and IS, respectively, being deficient in WDS (0.12%). Calcium was higher in PDS (0.56%), followed by IS (0.39%) and PDS (0.26%) Magnesium, K, Na, and Cu content in forage was higher than the suggested critical levels for cattle, while Fe and Mn were very height. In blood serum, P was low with higher values in younger animals (4.16, 3.44, 3.34 mg/dL for calves, heifers, and cows, respectively). Hepatic Cu (98 ppm), Zn (129 ppm), and Mn (9.7 ppm) were adequate, while Fe (287 ppm) was high, in line with forage and blood concentrations. In bone tissue, Ca (21.7%, 243 mg/cm3) and P (9.9%, 106 mg/cm3) concentrations were deficient. It is concluded that P deficiency is present in the soil-plant-animal system, eventually Ca in some components of the system (blood serum, bone and forage) and high concentrations of Fe, Mn and Zn are present and may be involved in some antagonistic relationships.

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Morbilidad en mujeres postmenopáusicas pobres/ Morbidity in postmenopausal women with poverty

NAVARRO R, MARY CARMEN; SAAVEDRA S, PEDRO; DE MIGUEL R, EMILIO; CASTRO M, ROSA; BONET DE LA N, MARIO; SOSA H, MANUEL
2010-02-01

Resumen en inglés Background: Less favored social classes usually have more unhealthy life-styles and a more difficult access to Health Resources. Aim: To study the possible association between poverty and some common diseases, in a population of postmenopausal women. Material and Methods: Four hundred and forty nine poor women aged 56 ± 12 years and 776 consecutive women aged 53 ± 12 years, answered a personal interview about their lifestyles and medications used. Their medical records (mas) were reviewed and they were subjected to a complete physical examination, including weight and height measurement. A fasting blood sample was also obtained. Poverty was defined according to criteria of the Spanish National Institute of Statistics that is based on the income in Euros and the number of family members that share such income. Results: A higher proportion of poor women live in rural areas. They were shorter, had a higher weight and thus a higher body mass index, smoked less and drank less alcohol than their non-poor counterparts drink. The consumption of caffeine, the actual calcium intake and the physical activity during leisure time was similar in both groups. Compared with their counterparts, poor women had a higher prevalence of diabetes mellitus (15.9 and 10.1% respectively, p = respectively, p = 0.03). A multiple logistic regression model showed that obesity, hypertension, diabetes mellitus, smoking, alcohol consumption and living in rural areas, were independently associated to poverty. Conclusions: Poor postmenopausal women have a higher prevalence of diabetes mellitus, obesity, autoimmune rheumatic diseases and hypertension and lower frequency of smoking and alcohol consumption than their affluent counterparts do

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Influencia del tratamiento hormonal sustitutivo en el perfil aterogénico de la mujer postmenopáusica/ Influence of estrogen replacement therapy on atherogenic profile in postmenopausal women

Alfonso Cano, C.; Vez García, M. D.; García Urruticoechea, P.; Tornel Osorio, P. L.; Canteras Jordana, M.; Abellán Alemán, J.
2003-02-01

Resumen en español Objetivo: El riesgo cardiovascular se eleva en la mujer tras la menopausia. Este estudio pretende comparar el perfil aterogénico de las mujeres postmenopáusicas respecto a las premenopáusicas y valorar la influencia que el tratamiento hormonal sustitutivo ejerce sobre dicho perfil aterogénico. Método: Se seleccionan 76 mujeres climatéricas de 45 a 59 años y 15 mujeres con ciclos menstruales regulares de 40 a 45 años. Concluyen el estudio 63 mujeres con menopausia (mas) natural, normotensas, no diabéticas que no habían recibido previamente tratamiento hormonal sustitutivo ni fármacos con efecto sobre el sistema cardiovascular. El grupo control lo forman 15 mujeres sanas con ciclos menstruales regulares, de 40 a 45 años. Reciben durante 6 meses tratamiento hormonal 27 mujeres (50 microgramos de estradiol transdérmico y 100 milígramos de progesterona oral) y no lo reciben 36 de ellas. Se realiza al inicio del estudio y a los 6 meses exploración física (peso, talla, índice cintura/cadera) y determinaciones analíticas (bioquímica general, estrógenos, homocisteína, cobre, fibrinógeno y proteína C reactiva). Al grupo control sólo se le realizan las exploraciones iniciales. Resultados: Los subgrupos de mujeres postmenopáusicas según reciban o no tratamiento hormonal, presentan al inicio del estudio niveles de estradiol inferiores al grupo control (10±3,99; 12±4,56 vs. 83±78,47 mg/l, p Resumen en inglés Objective: Postmenopausal women have higher risk of cardiovascular events compared with premenopausal. The aim of this clinical study was to evaluate the effect of hormone replacement therapy (HRT) on the atherogenic profile in apparently healthy postmenopausal women. Method: The subjects were 76 healthy postmenopausal women, aged 45 to 59 years, and 15 premenopausal women with regular cycles, aged 40 to 45 years. 63 postmenopausal women completed the study. None of the p (mas) articipating women had a history of hypertension, diabetes mellitus or medications known to affect the cardiovascular system. Twenty seven postmenopausal women received daily 50 micrograms of transdermal estradiol and 100 milligrams of oral progesterone. Thirty six dit not receive HRT. Checkups were preformed at baseline and after six months of treatment, except the group of premenopausal women (only at baseline). Examinations consisted in measurement of body weight, length, waist/hip ratio and plasma levels of biochemical parameters. Results: Estradiol levels were higher among premenopausal women than among treated and non-treated postmenopausal women (83±78.47 versus 10±3.99; 12±4.56 mg/l, p

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Influencia de factores de riesgo y terapia farmacológica en la mortalidad de hipertensos esenciales

Román A, Oscar; Cuevas S, Gerardo; Bunout B, Daniel
1998-07-01

Resumen en inglés Background: The VJN consensus stated that although new antihypertensive agents, such as angiotensin converting enzyme inhibitors and calcium channel blockers, are considered safer drugs, there is no firm evidence from large controlled trials that these drugs are associated with a lower cardiovascular mortality. Aim: To study the association between cardiovascular risk factors, blood pressure levels, pharmacological treatment and mortality in a group of hypertensive patien (mas) ts followed at an hypertension outpatient clinic. Patients and methods: Patients with essential hypertension were treated with different antihypertensive medications, according to physicians criteria, and controlled until death or loss from follow up. Causes of death were obtained from hospital records and death certificates. Survival was analyzed using life tables, comparisons between groups of patients were done using chi square or a CoxÕs proportional hazards model. Results: Three hundred thirty nine hypertensive patients aged 33 to 80 years old were followed for a mean period of 9.8 ± 4.9 years. Eighty six were treated with beta blockers, 64 with diuretics, 133 with calcium antagonists and 56 with ACE inhibitors. Blood pressure dropped similarly with all medications. During follow up, 79 patients died. Life table analysis showed that patients with a history of angina, diabetes or myocardial infarction had higher mortality rates. Similarly, patients treated with beta blockers and diuretics had higher mortality than patients treated with calcium antagonists or angiotensin converting enzyme inhibitors. The proportional hazards model showed that the effect of treatment modality persisted after correction for the other risk factors for mortality. Conclusions: In this series of hypertensive patients, those treated with beta blockers or diuretics had higher mortality rates than those receiving calcium channel antagonists or angiotensin converting enzyme inhibitors

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Fracturas vertebrales, osteoporosis y vitamina D en la posmenopausia: Estudio en 555 mujeres en Chile/ Vertebral fractures, osteoporosis and vitamin D levels in Chilean postmenopausal women

Rodríguez P, José A; Valdivia C, Gonzalo; Trincado M, Patricio
2007-01-01

Resumen en inglés Background: Approximately one-third of vertebral fractures can be clinically diagnosed. Aim: To study the frequency of vertebral fractures in postmenopausal women. Patients and methods: We recruited 555 postmenopausal women from Santiago, Chile, aged 55-84 years, who manifested interest in their bone health. All were healthy by self-declaration and by general clinical and laboratory tests and had not taken any bone-active therapy. They all underwent a spine and femoral ne (mas) ck (FN) densitometry and a digital lateral spine X-ray from T4 to L4 was obtained. PTH, calcidiol, and other parameters of calcium metabolism were also measured. Results: Overall, 142 of 478 patients with a complete study (29.7%) had at least one vertebral fracture. The proportion of women with fractures increased with age. A T score below -2.5 in the spine and hip was found in 32% and 14% of women, respectively. The proportion of women with spinal opeoporosis doubled between ages 55-70 and remained constant afterwards. In contrast, at the femoral neck, this proportion increased progressively reaching 53.3% at age 80-85. However, 56% of patients with vertebral fractures did not have densitometric osteoporosis in any location. Calcidiol levels were 16.8±6.8 ng/mL. With a cutoff point of 17 ng/mL, 47.5% of the patients had hypovitaminosis D. There was no association between calcidiol levels and vertebral fractures or bone density at the spine or femoral neck. Patients with fractures differed from those without fractures in that they had significantly lower bone density at the spine and hip and were older (p

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Factores predictores de riesgo de morbimortalidad en hipertensos esenciales seguidos 25 años/ Risk factors for morbidity and mortality in subjects with essential hypertension, followed for 25 years

Román A, Oscar; Cuevas, Gerardo; Badilla S, Marta; Valenzuela C, María Angélica; Cumsille G, Francisco; Valverde F, Luis; González M, Alejandra; Pulgar SM, María; Pino V, Claudia
2001-11-01

Resumen en inglés Background: Among hypertensive patients, other risk factors for mortality and morbidity, besides blood pressure, must be considered when therapeutic decisions are done. Aim: To assess the incidence and relevance of cardiovascular risk factors in a cohort of patients with essential hypertension. Material and methods: A cohort of 1.072 treated patients with essential hypertension was followed for a period up to 25 years. Four hundred eighty six were men and 586 were women, (mas) age ranged from 31 to 70 years. At entry, 56% of subjects did not have any organic complications associated to hypertension (stage I WHO criteria), 30% had mild alterations (Stage II) and 14% had major complications (myocardial infarction, stroke, heart failure or renal failure). Likewise, 43.8% had mild, 14.5%, moderate and 41.7%, severe hypertension. Patients were treated with monotherapy or combined therapy based on diuretics, beta blockers, calcium antagonists and angiotensin converting enzyme inhibitors. Goal of therapy was 140/90 mm Hg. Risk factors associated diseases and complications were registered carefully. Causes of death were obtained from hospital records and death certificates. Mortality was analyzed using life tables (intention to treat method included). Results: Blood pressure dropped significantly during follow up from a mean of 182/110 to 154/92 mm Hg. During follow up, 143 patients died and 429 complications (lethal or non lethal) were recorded. Twenty four percent of patients smoked, 24% reported alcohol intake, 56% had hypercholesterolemia, 11% were obese, 13% had diabetes and 3% had gout. The proportional hazard model showed that the existence of previous complications, the presence of more than 3 risk factors, and age over 60 and mean systolic and diastolic pressure during therapy, were independent and significant risk factors for mortality. Conclusions: The incidence of risk factors among our hypertensive patients is very similar to that of other national or international cohorts (Rev Méd Chile 2001; 129: 1253-61)

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Factores edáficos y de manejo que condicionan la eficiencia del barbecho en la región pampeana/ Soil and management factors that condition fallow efficiency in the Pampa region

Quiroga, Alberto Raúl; Funaro, Daniel Oscar; Fernández, Romina; Noellemeyer, Elke Johana
2005-07-01

Resumen en español En la región semiárida y subhúmeda pampeana las precipitaciones no logran cubrir los requerimientos de uso consuntivo de los cultivos y normalmente limitan el rendimiento y la respuesta a la fertilización. Una parte sustancial de las precipitaciones tiene lugar durante el periodo de barbecho y en su mayor parte no es utilizada por los cultivos. Los objetivos del trabajo fueron evaluar durante el periodo de barbecho, los efectos de a) longitudes de barbecho, b) variaci (mas) ones en la capacidad de retención de agua (CRA), c) niveles de cobertura y d) sistemas de labranza sobre: contenido de agua, temperatura, resistencia a la penetración (RP) y N-nitratos (N). Con respecto a las longitudes de barbecho estival se obtuvo que el barbecho de mayor longitud dio lugar a mayores contenido de agua (149 mm) y N (81 kg ha-1) respecto al barbecho medio (112 mm, 56 kg N ha-1) y corto (96 mm, 34 kg N ha-1). En Hapludoles la longitud del barbecho afectó principalmente la disponibilidad de N y no se registró diferencia en los contenidos de agua y RP. Sin embargo en Haplustoles énticos con tosca se registraron diferencias significativas en los contenidos de N, RP y agua. En suelos de baja CRA útil (42 mm) no se registraron diferencias entre hacer o no hacer barbecho, mientras que en Haplustoles con mayor CRA (90 y 210 mm) las diferencias en el contenido de agua y nitratos fueron significativas. Bajos niveles de cobertura dieron lugar a una menor eficiencia de barbecho, tanto en el almacenaje de agua como en la disponibilidad de N. También se observaron diferencias significativas en la cantidad de agua almacenada entre siembra directa (SD) (163 mm) y siembra convencional (SC) (118 mm). Asociado a un mayor contenido de agua se comprobó una menor RP en SD. Puede concluirse que las prácticas de manejo y en particular SD pueden incrementar la eficiencia del barbecho. La importancia de los efectos está condicionada en mayor medida por el CRA y por el régimen de precipitaciones. Resumen en inglés In the semiarid and subhumid pampa region rainfall does not cover the crops’ consumptive use and normally limits yields and fertilizer response. A substantial part of rain falls during the fallow period and a high proportion cannot be used by crops. The objectives of this study were to evaluate the effect of a) fallow duration, b) variation in the water retention capacity (CRA), c) soil cover and d) tillage systems on: water contents, temperature, soil resistance (RP), n (mas) itrate N (N). The longest summer fallow period resulted in highest water storage (149 mm) and N contents (81 kg ha-1) with respect to intermediate fallow (112 mm water storage, 56 kg N ha-1) and short fallow (96 mm water storage, 34 kg N ha-1). In Hapludoll soils fallow length mostly affected N availability and no effect on water storage and RP were found, while in entic Haplustolls with calcium carbonate hardpans the most significant effects were on water storage, N and RP. En soils with low CRA (42 mm) no difference between fallow and no-fallow treatments were observed, while in soils with high CRA (90 to 210 mm) significant differences in water and nitrate content were found. Low soil cover levels caused a lower water storage and N availability efficiency during fallow. We also encountered significant differences in summer fallow water storage between zero tillage (163 mm) and conventional tillage (118 mm). Due to the higher water content in zero tillage, this treatment also showed lower values of RP. It can be concluded that management practices, and in particular zero tillage can increase the efficiency of summer fallow. The importance of their effects is conditioned by soil water storage capacity and rainfall.

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Evaluación del lercanidipino en Atención Primaria: seguridad y eficacia. Resultados del estudio LAPSE/ Evaluation of lercanidipine in general practice setting

Robles, N. R.; Canelada, J. A.; Iglesias, M.; Angulo, E.; López Acedo, A.; Díaz Olea, E.; Cidoncha, F.; Guerras, M.; Fuentes, J.; Garrido, J.; Lapie, J.; Peña, J.; Aguilar, A.; Hidalgo, P.
2003-06-01

Resumen en español Objetivo: Evaluar la seguridad y eficacia de una calcioantagonista con escasos efectos secundarios en los estudios hospitalarios en el ambiente habitual de trabajo de Atención Primaria. Material y métodos: Se incluyeron 110 pacientes, de los cuales 104 terminaron el estudio. La edad media eran 62,3 ± 10,8 años, siendo 51 hombres y 53 mujeres. Un 38% de los pacientes eran obesos (IMC > 30 kg/m2) y 10 pacientes eran diabéticos. Los enfermos fueron tratados con le (mas) rcanidipino a la dosis de 10 mg una vez al día por la mañana. Los enfermos fueron examinados física y analíticamente al principio del estudio y a los 45, 90 y 180 días. En el caso de que la PA no estuviera controlada se añadía un segundo agente no calcioantagonista (se recomendó un agente antiadrenérgico y se reevaluaba al paciente 30 días después, siendo excluido si no había mejorado su PA. Resultados: La PAS se redujo desde 157,4 ± 11,7 hasta 131,1 ± 6,8 mmHg (p Resumen en inglés Objective: To determine the efficacy and tolerability of a long-acting dihydropyridine in the clinical settings of general practice. Material and methods: 110 essential hypertensives were included (age 62.3 ± 10.8 years, 51 men and 53 women, 38% obese -IMC >30 kg/m2, ten diabetics). 104 patients ended the followup. Patients were treated with lercanidipine 10 mg once daily in the morning. Follow-up lasted 6 months. When blood pressure was not controlled (BP (mas) mmHg) in any visit, a second drug was added, excluding calcium channel blockers. Antiadrenergic drugs were recommended. If patients were not controlled in two consecutive visits they were excluded from follow-up. Results: Significant reductions in both systolic (baseline 157.4 ± 11.7 vs 131.1 ± 6.8 mmHg, p

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Eficacia y complicaciones de la cirugía bariátrica en el tratamiento de la obesidad mórbida/ Effectiveness and complications of bariatric surgery in the treatment of morbid obesity

Ocón Bretón, J.; Pérez Naranjo, S.; Gimeno Laborda, S.; Benito Ruesca, P.; García Hernández, R.
2005-12-01

Resumen en español Introducción y objetivos: La cirugía bariátrica constituye una alternativa terapéutica eficaz en pacientes con obesidad mórbida refractaria al tratamiento médico. Sin embargo, estas técnicas quirúrgicas aumentan el riesgo de provocar una malnutrición proteicoenergética o el déficit selectivo de algunos micronutrientes. El objetivo de este trabajo ha sido analizar las modificaciones antropométricas, nutricionales, digestivas, factores de riesgo cardiovascular y (mas) calidad de vida en pacientes con obesidad mórbida sometidos a cirugía bariátrica. Material y métodos: Estudio descriptivo retrospectivo donde se ha evaluado a un grupo de pacientes con obesidad mórbida que fueron intervenidos de cirugía bariátrica (45 mediante bypass biliopancreático según técnica de Scopinaro y 25 mediante bypass gástrico laparoscópico). Se les realizó una valoración antropométrica (talla, peso, índice de masa corporal), factores de riesgo cardiovascular (tensión arterial, perfil lipídico, glucémico y uricemia) y parámetros nutricionales (albuminemia, estudio hematológico y fosfocálcico) antes de la técnica bariátrica y al año y dos años después del tratamiento quirúrgico. La calidad de vida se evaluó mediante el sistema B.A.R.O.S Resultados: Se ha analizado a 70 pacientes con obesidad mórbida (56 mujeres y 14 varones) con una edad media de 36,5 ± 11 años. El peso medio prequirúrgico fue de 129,7 ± 25,6 Kg y el IMC de 48,8 ± 8,8 Kg/m². A los dos años tras la técnica quirúrgica el IMC fue de 31,0 ± 6,6 Kg/m², la reducción ponderal de 47,7 Kg y el porcentaje de pérdida de peso del 36,5%. El 100% de los pacientes dislipémicos, el 90% de los diabéticos y el 72% de los hipertensos normalizaron sus perfiles correspondientes tras la cirugía. La complicación nutricional más común fue la anemia y la ferropenia que ocurrieron en el 54,4% y 36,6% de los casos respectivamente. Otros déficit nutricionales observados fueron: hipoalbuminemia leve en el 20,3% de los pacientes, hipoprotrombinemia en el 14,9%, descenso de ácido fólico en el 17,8%, déficit de vitamina B12 en el 12,5%, hipocalcemia en el 23,8% e hiperparatiroidismo secundario en el 45,4% de los casos. Todas las complicaciones nutricionales fueron más frecuentes en pacientes sometidos a bypass biliopancreático excepto en el caso del déficit de B12 que ocurrió con más frecuencia en pacientes con bypass gástrico. La complicación digestiva mas frecuentemente observada fue la diarrea/esteatorrea en el 39,1% de los casos. El 64,2% de los enfermos consideraron el resultado de la cirugía como excelente o muy bueno. Conclusión: En pacientes con obesidad mórbida, la cirugía bariátrica es una técnica con la que se consigue una gran mejoría en los parámetros antropométricos, en los factores de riesgo cardiovascular y en la calidad de vida de los pacientes, pero que conlleva asociadas un porcentaje importante de complicaciones nutricionales que deberemos tener en cuenta para poderlas prevenir. Resumen en inglés Introduction and objectives: Bariatric surgery represents an affective therapeutic alternative for patients with morbid obesity refractory to medical treatment. However, these surgical techniques increase the risk of producing a protein-energy hyponutrition or a selective deficit of some micronutrient. The aim of this work has been to analyze the anthropometrical, nutritional,digestive and cardiovascular risk factors changes and quality of life in patients with morbid obe (mas) sity submitted to bariatric surgery. Material and methods: Retrospective descriptive study evaluating a group of patients with morbid obesity submitted to bariatric surgery (45 by means of biliopancreatic bypass according to Scopirano’s procedure, and 25 by laparoscopic gastric bypass). Anthropometrics (height, weight, body mass index), cardiovascular risk factors (arterial blood pressure, lipid and glycemic profiles, serum uric acid) and nutritional parameters (serum albumin, complete blood count, and phosphorus and calcium) were assessed before the bariatric procedure and one and two years after surgical treatment. Quality of life was evaluated through the B.A.R.O.S. system. Results: Seventy patients with morbid obesity have been analyzed (56 women and 14 men) with a mean age of 36.5 ± 11 years. Mean pre-surgical weight was 129.7 ± 25.6 kg and BMI 48.8 ± 8.8 kg/m². Two years after the surgical procedure BMI was 31.0 ± 6.6 kg/m², the ponderal reduction 47.7 kg and the percentage of weight loss 36.5%. Hundred percent of dislipidemic patients, 90% of diabetic patients, and 72% of hypertensive patients normalized their corresponding profiles after surgery. The most common nutritional complications were anemia and iron deficiency, which occurred in 54.4% and 36.6% of the cases, respectively. Other observed nutritional deficits were: mild hypoalbuminemia in 20.3% of the patients, hypothrombinemia in 14.9%, folic acid decrease in 17.8%, vitamin B12 deficiency in 12.5%, hypocalcaemia in 23.8%, and secondary hyperparathyroidism in 45.4% of the cases. All nutritional complications were more frequent in patients submitted to biliopancreatic bypass, with the exception for vitamin B12 deficiency that occurred more frequently in patients with gastric bypass. The most frequently observed digestive complication was diarrhea/steatorrhea in 39.1% of the cases. Sixty-four point two percent of the patients considered the surgery outcome as excellent or very good. Conclusion: In patients with morbid obesity, bariatric surgery is a technique by which a great improvement in anthropometrical parameters, cardiovascular risk factors, and quality of life of patients is achieved, but it associates an important percentage of nutritional complications that we should take into account in order to prevent them.

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Efectos de diferentes relaciones de calcio y fósforo en el suelo sobre la nodulación de Acacia mangium (Willd) y Leucaena leucocephala (Lam) de Wit., en condiciones de vivero/ Effects of different relationships of calcium and phosphorus in the soil on the nodulación of Acacia mangium (Willd) and Leucaena leucocephala (Lam) of Wit under nursery conditions

Rincón¹, José. J; Gallardo, Yessica; Leal, Mónica; Rojas, Yubisay
2004-04-01

Resumen en español Se evaluó en condiciones de vivero la Acacia mangium y Leucaena leucocephala en diferentes relaciones de calcio: fósforo en el suelo [los tratamientos (Ca:P); SSE-CP(10:1), SSE-SP(31:1), SE-CP(44:1) y SE-SP(133:1)], sobre la nodulación (NNOD). Cuatro unidades experimentales fueron usadas por tratamientos y especie en cada muestreo, a los 45, 90 y 135 días después de la siembra, en un experimento totalmente al azar, con arreglo del tratamiento en factorial 2². El tra (mas) tamiento SSE-CP, a los 90 días fue estadísticamente superior (P Resumen en inglés The Acacia mangium and Leucaena leucocephala were evaluated under nursery conditions in different relationships of calcium: phosphorus in the soil [the treatments (Ca:P); SSE-CP(10:1), SSE-SP(31:1), SE-CP(44:1) and SE-SP(133:1)], on the nodulation (NNOD). Four experimental units were used by treatments and species in each sampling, to the 45, 90 and 135 days after the seeding, in an experiment completely at random, with arrangement of the treatment in factorial 2x2. The t (mas) reatment SSE-CP, to the 90 days was superior statistically (P

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Efecto diferencial sobre el IGF-1 sérico de tibolona (5 mg/día) vs combinado continuo de estrógeno/progestina en mujeres postmenopáusicas/ Effects on serum IGF-1 of tibolone (5 mg/day) vs combined continous estrogen/progestagen in post menopausal women

Porcile, Arnaldo; Gallardo, Enrique; Duarte, Patricia; Aedo, Sócrates
2003-10-01

Resumen en inglés Tibolone has estrogenic, androgenic and progestational effects and is used in post menopausal women. It apparently has weaker effects on endometrial proliferation and mammary stimulation than conventional hormone replacement therapy. Aim: To compare the metabolic effects of tibolone (5 mg/day) and continuous combined conjugated estrogens/medroxyprogesterone acetate in postmenopausal women. Patients and Methods: postmenopausal women, aged 45 to 60 years old, receiving estr (mas) adiol valerate and medroxyprogesterone were included in the study. After a two months wash out period, in a double blind fashion, they were randomly assigned to oral tibolone 5 mg/day or equine conjugated estrogens 0.625 mg + medroxiprogesterone acetate 2.5 mg/day (ECE/MPA). At baseline, 30 and 45 days of treatment, fasting serum osteocalcin, somatomedin C (IGF-1, insulin-like growth factor 1), growth hormone (GH), and follicle stimulating hormone and first morning urine calcium and creatinine were measured. Results: Thirty women were studied. There was more than 50% fall in urine calcium with either tibolone or ECE/MPA, while fasting GH or osteocalcin did not show significant changes. Serum IGF-1 increased significantly with tibolone at basal, 30 (+109%) and 45 days of treatment and did not change in the ECE/MPA group. Conclusions: Tibolone (5 mg/day) and ECE/MPA induced a similar reduction in urinary calcium. Tibolone increased serum IGF-1 levels. This may be due to undetected increment of overall GH secretion or to a specific action on IGF-1 generation from the liver and appears to be a novel differential effect of tibolone (Rev Méd Chile 2003; 131: 1151-56)

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Efecto de métodos de pastoreo sobre sabanas moduladas. II. Composición proteica y de minerales en planta y suelo/ Effect of the methods of grazing on modulated savannahs. II. Protein and minerals composition in plant and soil

Torres, René; Chacón, Eduardo; Machado, Wilfre; Astudillo, Luís; Carrasquel, José; García, Espedito
2003-11-01

Resumen en español El estudio fue desarrollado en el Módulo Experimental de Mantecal, estado Apure, Venezuela (7°35’ N y 69°10’ O), durante el período 1984-1998, con el objetivo de evaluar la interacción entre la producción primaria y secundaria de sabanas hiperestacionales. La vegetación dominante en los Bancos (zona fisiográfica alta) estuvo constituida por Panicum laxum, Paspalum chaffanjonii, Leersia hexandra y Axonopus compressus, conjuntamente con más de 80 especies; en los (mas) Bajíos (zona fisiográfica media) estuvo conformada por las tres primeras especies señaladas más Hymenachne amplexicaulis y 50 adicionales; y en los Esteros (zona fisiográfica baja), la inundación anual reduce la dominancia a L. hexandra e H. amplexicaulis, y a otras 15 especies hidrófilas. Se asignaron 200 ha con similares proporciones altas, medias y bajas, por tratamiento de Pastoreo Continuo (PC), Pastoreo Diferido (PD) con utilización de las zonas altas durante las lluvias, las zonas medias en la transición lluvia-sequía y sequía-lluvia, y las zonas bajas durante el periodo seco, y Pastoreo Diferido Rotativo (PDR) con uso similar al tratamiento PD, pero con tres subdivisiones en su zona media y seis en su zona baja. La modalidad de producción para los tratamientos fue de sistema vaca-maute, con temporada de monta durante el periodo de sequía y carga animal promedio de 0,50 UA/ha/año. La concentración proteica de las pasturas resultó deficiente solo bajo PC durante el periodo seco (PC=5,8; PD=6,6 y PDR=7,3 %), con incremento al inicio de las lluvias por zona en: alta (14,1%) Resumen en inglés Summary The research was carried out in the Experimental Module of Mantecal, Apure state, Venezuela (7°35' N and 69°10' W), during the period 1984-1998, with the objective of evaluate the interaction between the primary and secondary production on hyperstational savannas. The dominant vegetation in the Bancos (high physiographic zone) was constituted by the grasses Panicum laxum, Paspalum chaffanjonii, Leersia hexandra and Axonopus compressus and more than other 80 spec (mas) ies. In the Bajíos (medium physiographic zone) the vegetation was conformed by the grasses P. laxum, L. hexandra, P. chaffanjonii and Hymenachne amplexicaulis, plus another 50 species, while in the swamps or Esteros (low physiographic zone) the annual flood rhythm induces the dominance of L. hexandra and H. amplexicaulis grasses and other 15 hydrophyte species. Two hundred ha were assigned with similar proportions of high, medium and low physiographic zones to three different grazing methods: continuous (CG), deferred (DG) grazing as the use of higher areas during the peak of the rainy season, the medium areas in the transition rainy-dry and dry-rainy period, and the low areas during the dry period, and deferred-rotary Grazing (DRG), with similar grazing management than DG, but with three subdivisions in their medium and six on low physiographic zones, respectively. The production system in the three treatments was a cow-steer, with breeding season during the dry period, stocked at of 0.50 AU/ha/year. The DM protein concentration of the pastures were highly deficient only under CG, during the dry period (CG=5.8; DG=6.6; DRG=7.3%), with an increase at the beginning of the rainy season on: high (14.1%)

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Efecto de dosis bajas de calcitonina sobre la remodelación ósea en mujeres postmenopáusicas con alto recambio/ Effects of low calcitonin doses on bone remodeling in postmenopausal women with high bone turnover rate

Campusano M, Claudia; López M, José M.; Campino J, Carmen; Cárdenas G, Isabel; Rojas O, Auristela
2000-04-01

Resumen en inglés Background: Calcitonin is specially indicated for the treatment of osteoporosis in women that cannot receive estrogen replacement therapy or that have a high bone turnover rate. Aim: To study the effects of low intranasal calcitonin doses on bone remodeling in postmenopausal women with a high bone turnover. Patients and methods: Forty one healthy women aged 56 ± 6 years old, with a mean lapse after menopause of 7.6 ± 6.5 years and with a high bone turnover rate, evidenc (mas) ed by an urinary hydroxyproline (mg/dl)/creatinine (g/dl) ratio of 52.4 ± 7.2, were studied. They were randomly assigned to receive 100 or 50 U/calcitonin thrice a week during 3 months or to a control group that received placebo. All received 500 mg/day calcium carbonate. Urinary hydroxyproline/creatinine ratio was measured a 0, 15, 30, 60 and 90 days. Plasma bone fraction of alkanine phosphatases was measured at 0, 30 and 90 days. Results: Initial urinary hydroxyproline/creatinine ratio and plasma bone fraction of alkanine phosphatases were similar in all study groups and there was no change in these parameters during the study period. Conclusions: Intranasal calcitonin in doses of 100 U thrice a week or less, does not modify accelerated bone turnover in postmenopausal women. (Rev Méd Chile 2000; 128: 387-91)

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Déficit de Vitamina D en mujeres adultas de la Ciudad de Buenos Aires/ Vitamin D deficit in adult women living in Buenos Aires City

Arévalo, Cecilia E.; Núñez, Myriam; Barcia, Ricardo E.; Sarandria, Pablo; Miyazato, Miriam
2009-12-01

Resumen en español El déficit de vitamina D se asocia con importante morbilidad. El objetivo de este estudio fue investigar la frecuencia de este déficit en una población de mujeres adultas y su asociación con distintas variables. Se evaluaron 224 mujeres mayores de 30 años atendidas en tres consultorios de clínica médica de la Ciudad de Buenos Aires entre octubre de 2006 y marzo de 2008. El nivel de 25 OH vitamina D, por radioinmunoanálisis, se clasificó como suficiente (> 30 ng/m (mas) l), déficit leve (entre 20 y 30 ng/ml) y déficit grave ( Resumen en inglés Vitamin D deficiency is a common cause of morbidity. We prospectively studied 224 consecutive female patients in order to evaluate the prevalence of vitamin D deficiency and to assess the utility of various clinical and biochemical markers in predicting the deficiency. All of them were outpatients, 30 years old or older, and were evaluated from October 2006 through March 2008. Levels of 25 OH vitamin D > 30 ng/ml were considered sufficient. Mild deficiency was considered (mas) between 20 and 30 ng/ml and severe deficiency

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Combinación de un inhibidor de la enzima convertidora de la angiotensina con un antagonista del calcio versus la monoterapia con el IECA: eficacia terapéutica en hipertensión arterial esencial y regresión de la hipertrofia cardíaca/ Combination of a Converting Enzyme Inhibitor (ACEI) with a Calcium Antagonist versus Monotherapy with an ACEI: Therapeutic Efficacy in Essential Hypertension and Regression of Ventricular Hypertrophy

Brandani, Laura M. J.; Baglivo, Hugo P.; Rodríguez-Moncalvo, Juan J.; Verra, Fernando; Sánchez, Ramiro A.; Ramírez, Agustín J.
2006-06-01

Resumen en español Objetivo Evaluar la eficacia y la tolerancia, así como su acción sobre la regresión de la hipertrofia ventricular izquierda, de la combinación de benazepril más amlodipina (B + A) versus la monoterapia con benazepril (B). Material y métodos Se incluyeron 33 hipertensos esenciales. Durante 6 meses de tratamiento, 18 de ellos recibieron B + A (9 varones, 55 ± 2 años) y los 15 restantes recibieron B (10 varones, 49 ± 2 años). Se realizó una presurometría (MAPA) a (mas) l comienzo y a los 3 y a los 6 meses de tratamiento. En un subgrupo de 23 pacientes se calculó la masa ventricular izquierda (MVI) y el índice de MVI (IMVI) al inicio y al final del tratamiento. Resultados A los 3 meses de tratamiento, los valores de la presión arterial (PA) fueron significativamente menores (p Resumen en inglés Objective To evaluate the effectiveness, tolerability and effect on the regression of left ventricular hypertrophy, of a combination therapy of amlodipine and benazepril (B+A), versus monotherapy with benazepril (B). Methods We included 33 patients (p) with essential hypertension. During 6 months of treatment, 18 p received B+A (9 men, 55±2 years) and 15 received B (10 men, 49±2 years). An ambulatory blood pressure monitoring (ABPM) was performed at the beginning and at (mas) 3 and 6 months of therapy. In a subgroup of 23 patients, left ventricular mass (LVM) and LVM index (LVMI) were calculated from the two dimensional echocardiogram, at the beginning and the end of treatment. Results At 3 months of treatment, blood pressure (BP) values were significantly (p

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Caracterización química de la vidriera del rosetón del Duomo de Siena (Italia, 1288-1289)

Gimeno, D.; Aulinas, M.; Bazzocchi, Flavia; Fernandez-Turiel, J. L.; García-Vallés, M.; Novembre, D.; Basso, E.; Messiga, B.; Riccardi, Maria Pia; Tarozzi, Camillo; Mendera, M.
2010-06-01

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Cambios neuropsicológicos y neurofisiológicos en la enfermedad de Fahr: Report of three sisters/ Neuropsychological and neurophysiological features of Fahr’s disease

Cartier R, Luis; Passig V, Claudia; Gormaz W, Adriana; López C, Javier
2002-12-01

Resumen en inglés Background: Fahr’s disease (basal ganglia calcification) is characterized by bi hemispherical calcium deposition in basal ganglia, dentate nucleus and semioval center. Its clinical manifestations are a rigid hypokinetic syndrome, mood disorders and cognitive impairment. Aim: To report to the results of a neurological assessment of three siblings with Fahr disease. Patients and methods: Three sisters, aged 55, 56 and 58 years, were studied. All had a rigid hypokinetic cli (mas) nical picture associated with cerebellar involvement and a cognitive impairment that progressed in 8, 6 and 10 years respectively. Brain CAT scans showed symmetric and extensive calcifications of cerebellar white matter and dentate nuclei, pons, mesencephalon, lenticular nuclei, thalami and semioval centers. Hypoparathyroidism was ruled out. Cognition was assessed with WAIS and Benton tests and Weschler memory scale. The time of reaction to visual stimuli was studied. The processing speed of visual information and the interhemispheric conduction time of such information, were calculated. Cognitive evoked potentials (P 300) were also studied. Results: Cognitive impairment involved verbal and visual-spatial memory, planning, attention and concentration capacities and visual constructive skills. There was a prolongation of reaction time latencies and loss of the normal asymmetry of interhemispheric transmission (without right to left facilitation). P 300 evoked potentials were absent. Conclusions: These observations suggest that the pathogenesis of cognitive and motor changes in Fahr’s disease is based in a dysfunction of cortico basal connections and their interhemispheric relations. This defines a subcortical dementia secondary to mineral deposits in subcortical structures ( Rev Méd Chile 2002; 130: 1383-90)

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Biochemical parameters during reproduction of the toad fish, Halobatrachus didactylus (Schneider, 1801)

Rosety, Manuel; Blanco, Miguel; González de Canales, María Luisa; Grau, Amalia; Sarasquete, M.ª Carmen
1992-01-01

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Análisis crítico de un artículo:El estudio ALLHAT: Diuréticos tipo tiazidas serían el fármaco de elección para iniciar tratamiento en hipertensión arterial/ The antihypertensive and lipid lowering treatment to prevent heart attack: Major outcomes in high risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002; 288: 2981-98

Rada G, Gabriel; Montero L, Joaquín
2004-04-01

Resumen en inglés Context: Antihypertensive therapy is well established to reduce hypertension related morbidity and mortality, but the optimal first step therapy is unknown. OBJECTIVE: To determine whether treatment with a calcium channel blocker or an angiotensin converting enzyme inhibitor lowers the incidence of coronary heart disease (CHD) or other cardiovascular disease (CVD) events vs treatment with a diuretic. DESIGN: The Antihypertensive and Lipid Lowering Treatment to Prevent Hea (mas) rt Attack Trial (ALLHAT), a randomized, double blind, active controlled clinical trial conducted from February 1994 through March 2002. Setting and participants: A total of 33357 participants aged 55 years or older with hypertension and at least 1 other CHD risk factor from 623 North American centers. INTERVENTIONS: Participants were randomly assigned to receive chlorthalidone, 12.5 to 25 mg/d (n = 15255); amlodipine, 2.5 to 10 mg/d (n = 9048); or lisinopril, 10 to 40 mg/d (n = 9054) for planned follow up of approximately 4 to 8 years. Main outcome measures: The primary outcome was combined fatal CHD or nonfatal myocardial infarction, analyzed by intent to treat. Secondary outcomes were all cause mortality, stroke, combined CHD (primary outcome, coronary revascularization, or angina with hospitalization), and combined CVD (combined CHD, stroke, treated angina without hospitalization, heart failure [HF], and peripheral arterial disease). Results: Mean follow up was 4.9 years. The primary outcome occurred in 2956 participants, with no difference between treatments. Compared with chlorthalidone (6 years rate, 11.5%), the relative risks (RRs) were 0.98 (95% CI, 0.90-1.07) for amlodipine (6 years rate, 11.3%) and 0.99 (95% CI, 0.91-1.08) for lisinopril (6 years rate, 11.4%). Likewise, all cause mortality did not differ between groups. Five years systolic blood pressures were significantly higher in the amlodipine (0.8 mm Hg, P =.03) and lisinopril (2 mm Hg, P

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Alta prevalencia de osteoporosis en mujeres mapuches postmenopáusicas asintomáticas/ High prevalence of osteoporosis in asymptomatic postmenopausal Mapuche women

Ponce L, Lucía; Larenas Y, Gladys; Riedemann G, Pablo
2002-12-01

Resumen en inglés Background: Genetic and environmental factors are responsible for variations in the frequency of osteoporosis. Prevalence of osteoporosis in Mapuche women (native Chileans) is unknown. Aim. To assess the prevalence and risk factors for osteoporosis in Mapuche women. Material and method. A random sample of 95 asymptomatic postmenopausal Mapuche females, stratified by age, was studied. Women with diseases or medications that could interfere with calcium metabolism were excl (mas) uded. Spine and femoral neck bone mass density was determined using a Lunar DPX Alpha densitometer. Results: Seventeen percent of women had normal bone mineral density in both spine and femoral neck. In the spine, 25.3% had a normal bone mineral density, 17.9% had osteopenia and 56.8% had osteoporosis. In the femoral neck, 34.7% had a normal bone mineral density, 57.9% had osteopenia, and 7.4% had osteoporosis. There was a positive correlation between bone mineral density and body mass index. Women with more than one hour per day of physical activity, had a significantly lower proportion of osteopenia or osteoporosis. No association between bone mineral density and parity or calcium intake, was observed. Conclusions: There is a high prevalence of osteopenia and osteoporosis among Mapuche women. Osteoporosis was associated with low body mass index (Rev Méd Chile 2002; 130: 1365-72)

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