Sample records for VIRULENZ (virulence)

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Virulence and Karyotype Analyses of rad52 Mutants of Candida albicans: Regeneration of a Truncated Chromosome of a Reintegrant Strain (rad52/RAD52) in the Host

Larriba, Germán; Chauhan, Neeraj; Rodríguez-Alejandre, Ane; Ciudad, Toni; Calderone, Richard; Andaluz, Encarnación

The virulence of Candida albicans mutants lacking one or both copies of RAD52, a gene involved in homologous recombination (HR), was evaluated in a murine model of hematogenously disseminated candidiasis. In this study, the virulence of the rad52Δ mutant was dependent upon the inoculum concentration...

DRIVER (German)


Successful termination of a furunculosis outbreak due to lukS-lukF-positive, methicillin-susceptible Staphylococcus aureus in a German village by stringent decolonization, 2002-2005

Wiese-Posselt, Miriam; Heuck, Dagmar; Draeger, Andreas; Mielke, Martin; Witte, Wolfgang; Ammon, Andrea; Hamouda, Osamah

Background: Skin infections due to Staphylococcus aureus have recently become a public concern, mainly because of emerging resistance against widely used antibiotics and specific virulence determinants. Strains harboring the lukS-lukF gene (which codes for Panton-Valentine leukocidin) are fre...

DRIVER (German)


Phenotypic Analysis and Virulence of Candida albicans LIG4 Mutants

Larriba, Germán; Andaluz, Encarnación; Reyes, Guadalupe; Calderone, Richard

In previous studies, we reported the isolation and preliminary characterization of a DNA ligase-encoding gene of Candida albicans. This gene (LIG4) is the structural and functional homologue of both yeast and human ligase IV, which is involved in nonhomologous end joining (NHEJ) of DNA double-strand...

DRIVER (German)