Sample records for TRANSKRIPTION (transcription)

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Untersuchung möglicher immunologischer Zielstrukturen für eine adjuvante Therapie des operablen Plattenepithelkarzinoms des Ösophagus

Siegmund, Annika

Einleitung: Ösophaguskarzinome haben generell eine schlechte Prognose und der Nutzen der derzeitig verfügbaren adjuvanten Therapien wird nach wie vor kontrovers diskutiert. Aufgabe dieser Arbeit war die Expressionsanalyse zweier möglicher immunologischer Zielstrukturen für eine adjuvante Therapie de...

DRIVER (German)


Two different pathways are involved in the beta-oxidation of n-alkanoic and n-phenylalkanoic acids in Pseudomonas putida U: genetic studies and biotechnological applications

Olivera, Elías R.; Carnicero, David; García, Belén; Miñambres Rodríguez, Baltasar; Moreno, Miguel A.

12 pages, 4 figures.-- PMID: 11251808 [PubMed]. | In Pseudomonas putida U, the degradation of n-alkanoic and n-phenylalkanoic acids is carried out by two sets of beta-oxidation enzymes (betaI and betaII). Whereas the first one (called betaI) is constitutive and catalyses the degradation of n-alkanoi...

DRIVER (German)


Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificity.

Rutter, W J; Johnson, J D; Rudnick, A; Zhang, W; German, M S

LIM-homeodomain proteins direct cellular differentiation by activating transcription of cell-type-specific genes, but this activation requires cooperation with other nuclear factors. The LIM-homeodomain protein Lmx1 cooperates with the basic helix-loop-helix (bHLH) protein E47/Pan-1 to activate the ...

DRIVER (German)


The insulin gene contains multiple transcriptional elements that respond to glucose.

German, M S; Wang, J

The beta cells in the pancreatic islets of Langerhans increase insulin gene transcription in response to increased glucose concentration. We have mapped sequences within the rat insulin I gene 5'-flanking DNA (rInsI promoter) that direct this transcriptional response to glucose. When linked to chlor...

DRIVER (German)


The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells

Lu, Danhong; Knop, Filip Krag; Takekawa, Shiro; Becker, Thomas C.; Schisler, Jonathan C.; Jensen, Per Bo; Weir, Gordon C.

We have previously described rat insulinoma INS-1-derived cell lines with robust or poor glucose-stimulated insulin secretion (GSIS). In the current study, we have further resolved these lines into three classes: class 1, glucose-unresponsive/glucagon-expressing; class 2, glucose-unresponsive/glucag...

DRIVER (German)


The Homeodomain of PDX-1 Mediates Multiple Protein-Protein Interactions in the Formation of a Transcriptional Activation Complex on the Insulin Promoter

Johnson, Jeffrey D.; Ohneda, Kinuko; Wang, Juehu; Mirmira, Raghavendra G.; German, Michael S.

Activation of insulin gene transcription specifically in the pancreatic β cells depends on multiple nuclear proteins that interact with each other and with sequences on the insulin gene promoter to build a transcriptional activation complex. The homeodomain protein PDX-1 exemplifies such interaction...

DRIVER (German)


Sox9 coordinates a transcriptional network in pancreatic progenitor cells

Yang, K. Y.; Lynn, F. C.; Wilson, M. E.; Smith, S. B.; Nekrep, N.; German, M. S.

During pancreas development, both the exocrine and endocrine lineages differentiate from a common pool of progenitor cells with similarities to mature pancreatic duct cells. A small set of transcription factors, including Tcf2, Onecut1, and Foxa2, has been identified in these pancreatic progenitor c...

DRIVER (German)


Rapid and simultaneous detection of avian influenza and Newcastle disease viruses by duplex polymerase chain reaction assay

Farkas Tibor (kutató); Antal Márta (kutató); Sámi László; Germán Péter; Belák Sándor; Kiss István (mikrobiológus)

DRIVER (German)


Paired-Homeodomain Transcription Factor PAX4 Acts as a Transcriptional Repressor in Early Pancreatic Development

German, Michael S.; Smith, Stuart B.; Conners, Jennifer R.; Ee, Hooi C.

The paired-homeodomain transcription factor PAX4 is expressed in the developing pancreas and along with PAX6 is required for normal development of the endocrine cells. In the absence of PAX4, the numbers of insulin-producing β cells and somatostatin-producing δ cells are drastically reduced, while t...

DRIVER (German)


Molekulare Analyse von Tumorsuppressorgen-Kandidaten auf Chromosom 10 in Tumoren des Nervensystems

Köhler, Benjamin

Deletionen des Chromosoms 10 stellen eine häufige Veränderung in unterschiedlichen Tumoren des Nervensystems dar. Sie finden sich u.a. in der Mehrzahl der Glioblastome, aber auch in Subgruppen von atypischen und anaplastischen Meningeomen sowie Medulloblastomen. Der häufige Verlust von genetischem M...

DRIVER (German)


Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins

German, Michael S.; Watada, Hirotaka; Kalamaras, Julie; Mirmira, Raghavendra G.

The developmentally important homeodomain transcription factors of the NK-2 class contain a highly conserved region, the NK2-specific domain (NK2-SD). The function of this domain, however, remains unknown. The primary structure of the NK2-SD suggests that it might function as an accessory DNA-bindin...

DRIVER (German)


Hes6 Promotes Cortical Neurogenesis and Inhibits Hes1 Transcription Repression Activity by Multiple Mechanisms

Theriault, Francesca M.; Gratton, Michel-Olivier; Jasmin, Stephanie Belanger; Torban, Elena; German, Michael S.

Hes1 is a mammalian basic helix-loop-helix transcriptional repressor that inhibits neuronal differentiation together with corepressors of the Groucho (Gro)/Transducin-like Enhancer of split (TLE) family. The interaction of Hes1 with Gro/TLE is mediated by a WRPW tetrapeptide present in all Hairy/Enh...

DRIVER (German)


Consistency in Transcription and Labelling of German Intonation with GToBI

Grice, Martine; Reyelt, Matthias; Benzmüller, Ralf; Mayer, Jörg; Batliner, Anton

DRIVER (German)


Children's Gestures from 18 to 30 months

Andrén, Mats

This thesis concerns the nature of the gestures performed by five Swedish children. The children are followed from 18 to 30 months of age: an age range which is characterized by a rapid succession of developmental changes in children's abilities to communicate by means of both spoken language and ge...

DRIVER (German)


Automatic Transcription of Football Commentaries in the MUMIS Project

Sturm, Janienke; Kessens, Judith M; Wester, Mirjam; de Wet, Febe; Sanders, Eric; Strik, Helmer

This paper describes experiments carried out to automatically transcribe football commentaries in Dutch, English and German for multimedia indexing. Our results show that the high levels of stadium noise in the material create a task that is extremely difficult for conventional ASR. The baseline WER...

DRIVER (German)


A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured islets

German, Michael S.; Sander, Maike; Huang, Juemin; Griffen, Steven C.

Insulin gene transcription is limited to the beta cells within the mammalian pancreas and, like insulin secretion, is regulated by glucose. Our previous studies in primary cultured beta cells suggested the presence of a strong glucose-responsive enhancer element between base pairs −341 and −260 of t...

DRIVER (German)