Sample records for TUMORE (neoplasms)

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The genotoxic air pollutant 3-nitrobenzanthrone and its reactive metabolite N-hydroxy-3-aminobenzanthrone lack initiating and complete carcinogenic activity in NMRI mouse skin.

Schmeiser, Heinz H.; Furstenberger, Gerhard; Takamura-Enya, Takeji; Phillips, David H.; Arlt, Volker M.

3-Nitrobenzanthrone (3-NBA), a genotoxic mutagen found in diesel exhaust and ambient air pollution and its active metabolite N-hydroxy-3-aminobenzanthrone (N-OH-3-ABA) were tested for initiating and complete carcinogenic activity in the NMRI mouse skin carcinogenesis model. Both compounds were found...

DRIVER (German)


The effect of amino acids and amino acid derivates on cell proliferation

Szende, B.; Semmelweis University of Budapest; University of Parma; Medical Faculty

German National Library of Science and Technology (GetInfo) (German)


The effect of amino acids and amino acid derivates on cell proliferation

Szende, B.; Universita Semmelweis di Budapest; Universita di Parma; Facolta di Medicina

German National Library of Science and Technology (GetInfo) (German)


The Kallikrein-Related Peptidases hK2 and PSA with Emphasis on Genetic Variation, Secretion, and Sperm Motility

Sävblom, Charlotta

Prostate-specific antigen (PSA) and human glandular kallikrein 2 (hK2) are secreted by the prostate into seminal plasma and through leakage into blood. This leakage increases rapidly in prostate disease, and PSA is used worldwide as a marker of prostate cancer. PSA is activated in vitro by hK2, and ...

DRIVER (German)


Skin cancer screening campaign in the German speaking Community of Belgium.

Nikkels, Arjen; Tassoudji, Nazli; Jerusalem-Noury, E; Sandman-Lobusch, H; Sproten, G; Zeimers, G; Schroeder, J; Pierard, Gérald

The incidence of primary malignant melanoma (MM) and skin carcinomas, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), is progressively raising. As long as their diagnosis and therapeutic managements are initiated early, their prognosis remains favorable. This underlines the i...

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Results of selective neck dissection in the primary management of head and neck squamous cell carcinoma.

Schmitz, Sandra; Machiels, Jean-Pascal; Weynand, Birgit; Gregoire, Vincent; Hamoir, Marc

Selective neck dissection (SND) is known to be a valid procedure to stage the clinically N0 neck but its reliability to control metastatic neck disease remains controversial. This study analysed if selective neck dissection is a reliable procedure to prevent regional metastatic disease in head and n...

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Re-use of pectoralis major myocutaneous flap for the treatment of recurrent hypopharyngeal stenosis following total laryngectomy and postoperative radiotherapy: a case report.

Van Haverbeke, Christophe; Lawson, Georges; Remacle, Marc

Management of recurrent hypopharyngeal stenosis following total laryngectomy and postoperative radiotherapy is a challenging problem. Because of previous surgery, free flaps may not always be performed. We report a case of recurrent hypopharyngeal stenosis after a first attempt of reconstruction wit...

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Proposal for revision of the European Laryngological Society classification of endoscopic cordectomies.

Remacle, Marc; Van Haverbeke, Christophe; Eckel, Hans; Bradley, Patrick; Chevalier, Dominique; Djukic, Votko; de Vicentiis, Marco

A classification of laryngeal endoscopic cordectomies, which included eight different types, was first proposed by the European Laryngological Society in 2000. The purpose of this proposal of classification was an attempt to reach better consensus amongst clinicians and agree on uniformity in report...

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Prognostic value of cell proliferation markers, tumour suppressor proteins and cell adhesion molecules in primary squamous cell carcinoma of the larynx and hypopharynx.

Liu, Ming; Lawson, Georges; Delos, Monique; Jamart, Jacques; Chatelain, Bernard; Remacle, Marc; Marbaix, Etienne

In an attempt to identify molecular prognostic markers, a series of laryngeal and hypopharyngeal carcinomas was examined for PCNA, Ki67, p27(Kip1), p53, E-cadherin and CD44 by immunohistochemistry and for DNA content by flow cytometry. No correlation was found between E-cadherin, CD44, p53 or DNA pl...

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Primary combined squamous and small cell carcinoma of the larynx: Report of two cases and discussion of treatment modalities.

Barbeaux, Annelore; Duck, Lionel; Weynand, Birgit; Desuter, Gauthier; Hamoir, Marc; Gregoire, Vincent; Baurain, Jean-François

Combined small cell carcinoma (SMCC) of the larynx consists of SMCC admixed with a component of squamous cell carcinoma or adenocarcinoma. These tumors are very rare and, to date, only a few cases have been fully described. This points out the lack of information available about the correct manageme...

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Posthemicricoidectomy reconstruction with a composite hyoid-sternohyoid osseomuscular flap: the Rethi-Ward technique.

Hantzakos, A; Evrard, A-S; Lawson, Georges; Remacle, Marc

Our objective was to introduce a new technique for cricoid cartilage reconstruction. A 74-year-old male patient with a history of a 6-month progressively worsening dyspnea was found to have an extensive mass of the left cricoid cartilage. Although the extent of his disease would necessitate total la...

DRIVER (German)


Plasma 25-hydroxyvitamin D and premenopausal breast cancer risk in a German case-control study.

Abbas, Sascha; Chang-Claude, Jenny; Linseisen, Jakob

Laboratory and epidemiological data have linked vitamin D to breast cancer prevention. Beside dietary intake, endogenous production of vitamin D substantially contributes to a subject's vitamin D status. Most studies, however, have assessed dietary intake only. Although differential effects of vitam...

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Obstructive sleep apnea syndrome after reconstructive laryngectomy for glottic carcinoma.

Rombaux, Philippe; Hamoir, Marc; Plouin-Gaudon, I; Liistro, Giuseppe; Aubert, Geneviève; Rodenstein, Daniel

Obstructive sleep apnea syndrome (OSAS) is characterized by repetitive episodes of partial or complete obstruction of the upper airway during sleep. The obstruction predominantly occurs along the pharyngeal airway but other sites of obstruction have occasionally been described. We report our experie...

DRIVER (German)


Neuropathology in the third Reich

Lechi, A.; Trabattoni, G. R.; Universita Semmelweis di Budapest

German National Library of Science and Technology (GetInfo) (German)


Lung cancer risk among former uranium miners of the WISMUT Company in Germany.

Brüske-Hohlfeld, Irene; Rosario, Angelika Schaffrath; Wölke, Gabriele; Heinrich, Joachim; Kreuzer, Michaela; Kreienbrock, Lothar

Lifestyle modulation of cancer & cancer biomarkersLifestyle element evaluated: attained age, time since exposure, exposure duration, and exposure rateOutcome studied (cancer or cancer biomarker): lung cancerMethod of biomarker analysis: job-exposure-matrix (JEM) by reference (Kreuzer M, Brachner A, ...

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Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients

Hohn, Oliver; Krause, Hans; Barbarotto, Pia; Niederstadt, Lars; Beimforde, Nadine; Denner, Joachim; Miller, Kurt

Background: A novel gammaretrovirus named xenotropic murine leukemia virus-related virus (XMRV) has been recently identified and found to have a prevalence of 40% in prostate tumor samples from American patients carrying a homozygous R462Q mutation in the RNaseL gene. This mutation impairs...

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Is frozen section reliable in transoral CO(2) laser-assisted cordectomies?

Remacle, Marc; Matar, Nayla; Delos, Monique; Nollevaux, Marie-Cecile; Jamart, Jacques; Lawson, Georges

Endoscopic resection of laryngeal tumors is replacing external approaches. One drawback of endoscopic resection is the difficulty of interpretation of histological specimens because of thermal effect of laser on tissues. Our goal is to assess the reliability of frozen section in this setting by comp...

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Früherkennung kolorektaler Neoplasien mittels hochauflösender Videokoloskope bei deutschen Männern zwischen 40 und 59 Lebensjahren ohne Risikofaktoren

Vogelsang, Eva Franziska

Prevalence data for colorectal neoplastic lesions for a German average-risk population 40 - 59 yrs. of age obtained from screening colonoscopy have not been published. A screening colonoscopy was offered to all male participants of a health assessment programme. By using high-resolution endoscopes a...

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Exudative lesions of Reinke's space: a terminology proposal.

Hantzakos, A; Remacle, Marc; Dikkers, F G; Degols, J-C; Delos, Monique; Friedrich, G; Giovanni, A; Rasmussen, N

There has been an ongoing confusion among pathologists in their attempt to accurately identify lesions of Reinke's space. Nodules, polyps and Reinke's edema fall in the same basket and differentiation between them relies largely on the clinical description of the pathologic specimen by the operating...

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Epithelial-myoepithelial carcinoma of the submandibular gland with symptomatic lung metastases treated with chemotherapy.

Pierard, Sophie; Gregoire, Vincent; Weynand, Birgit; Machiels, Jean-Pascal

This report concerns a patient with symptomatic lung metastases from an epithelial-myoepithelial carcinoma of the submandibular gland. Although the efficacy of chemotherapy is unknown in this disease, our patient was treated with cisplatin combined with 5-fluorouracil and later with paclitaxel and c...

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Endoscopic supraglottic laryngectomy: a proposal for a classification by the working committee on nomenclature, European Laryngological Society.

Remacle, Marc; Hantzakos, Anastasios; Eckel, Hans; Evrard, Anne-Sophie; Bradley, Patrick J; Chevalier, Dominique

In July 1999, the European Laryngological Society (ELS) has accepted a proposal for the classification of different laryngeal endoscopic cordectomies. This is actually a common classification system used as a tool for surgical training, documentation and comparison of results. The same harmonization...

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Endoscopic cordectomy. A proposal for a classification by the Working Committee, European Laryngological Society.

Remacle, Marc; Eckel, H E; Antonelli, A.; Brasnu, D; Chevalier, D.; Friedrich, G; Olofsson, J; Rudert, H H; Thumfart, W

The European Laryngological Society is proposing a classification of different laryngeal endoscopic cordectomies in order to ensure better definitions of post-operative results. We chose to keep the word "cordectomy" even for partial resections because it is the term most often used in the surgical ...

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Endonasal endoscopic resection of an ethmoidal solitary fibrous tumor.

Eloy, Philippe; Nollevaux, Marie-Cécile; Watelet, J B; Van Damme, J P; Collet, S T; Bertrand, Bernard

Solitary fibrous tumor (SFT) is an uncommon spindle cell tumor that typically arises at the level of the pleura in adults. However, SFT has also been reported in various extrapleural sites including orbit, meninges, liver, lung, salivary glands, retroperitoneum, mediastinum. In the head and neck reg...

DRIVER (German)


Endocrine tumors of the pancreas: the pathologist's approach

Bordi, C.; Semmelweis University of Budapest; University of Parma; Medical Faculty

German National Library of Science and Technology (GetInfo) (German)


Endocrine tumors of the pancreas: the pathologist's approach

Bordi, C.; Universita Semmelweis di Budapest; Universita di Parma; Facolta di Medicina

German National Library of Science and Technology (GetInfo) (German)


ECNIS-sponsored workshop on biomarkers of exposure and cancer risk: DNA damage and DNA adduct detection and 6th GUM-32P-postlabelling workshop, German Cancer Research Center, Heidelberg, Germany, 29-30 September 2006.

Arlt, Volker M.; Frei, Eva; Schmeiser, Heinz H.

Of all the chemicals classified as carcinogenic to humans by the International Agency for Research on Cancer (IARC), 90% exert their biological effects through binding of their metabolically activated intermediates to DNA forming covalent DNA adducts. As a consequence DNA adducts are generally consi...

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Congenital fistula of the fourth branchial pouch.

Hamoir, Marc; Rombaux, Philippe; Cornu, A S; Clapuyt, Philippe

Between 1986 and 1995, 128 patients were treated for various head and neck congenital malformations at Saint-Luc University Hospital, Louvain. We report three cases of fourth branchial pouch cysts requiring surgical removal. One of these cases presented with a third branchial pouch remnant on the sa...

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CO2 laser in the diagnosis and treatment of early cancer of the vocal fold.

Remacle, Marc; Lawson, Georges; Jamart, Jacques; Minet, Michèle; Watelet, J B; Delos, Monique

A total of 74 patients underwent cordectomy using CO2 laser for either diagnosis or treatment of an early cancer of the vocal fold. Type I cordectomy consisted in the resection of the entire epithelium, while leaving the vocal ligament intact. Type II cordectomy involved removal of the vocal fold fr...

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Blood glucose and risk of incident and fatal cancer in the metabolic syndrome and cancer project (Me-Can) : analysis of six prospective cohorts.

Stocks, Tanja; Rapp, Kilian; Bjorge, Tone; Manjer, Jonas; Ulmer, Hanno; Selmer, Randi; Lukanova, Annekatrin; Johansen, Dorthe

  Background Prospective studies have indicated that elevated blood glucose levels may increase the risk of cancer, but the strength of the association is unclear. We examined the association between blood glucose and cancer risk in a prospective study of six European cohorts. Methods and Findings T...

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Activity of chemotherapy in the palliative treatment of salivary gland tumors: review of the literature.

Rizk, Sophia; Robert, Annie; Vandenhooft, Annick; Airoldi, Mario; Kornek, Gabriela; Machiels, Jean-Pascal

Chemotherapy is sometimes used as palliation for patients with salivary gland tumors not amenable to curative treatment. However, if chemotherapy improves survival is unknown. To identify some prognostic parameters in this disease, we conducted an extensive review of the literature. The prognostic v...

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