Sample records for LYMPHOZYTEN (lymphocytes)

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The Regulation of Murine Lupus

Peng, S. L.; Craft, J.; New York Academy of Sciences

German National Library of Science and Technology (GetInfo) (German)


Somatic intragenic recombination within the mutated locus BLM can correct the high sister-chromatid exchange phenotype of Bloom syndrome cells.

Alhadeff, B; Ellis, N A; Proytcheva, M; Lennon, D J; Henderson, E E; German, J

Cells from persons with Bloom syndrome feature an elevated rate of sister-chromatid exchange (SCE). However, in some affected persons a minority of blood lymphocytes have a normal SCE rate. Persons who inherit the Bloom syndrome gene BLM identical by descent from a common ancestor very rarely exhibi...

DRIVER (German)


Natural Autoantibodies, Tolerance, and Autoimmunity

Dighiero, G.; New York Academy of Sciences; Institute of Rheumatology of Prague

German National Library of Science and Technology (GetInfo) (German)


Chemokine-receptor activation by env determines the mechanism of death in HIV-infected and uninfected T lymphocytes

Heppelmann, Carrie J.; Vlahakis, Stacey R.; Bou, German; Algeciras-Schimnich, Alicia; Villasis-Keever, Angelina

There is considerable confusion concerning the mechanism of lymphocyte death during HIV infection. During the course of HIV infection, M-tropic viruses (R5) that use CCR5 chemokine coreceptors frequently evolve to T-tropic viruses (X4) that use CXCR4 receptors. In this study we show that activation ...

DRIVER (German)


Bloom's syndrome. IV. Sister-chromatid exchanges in lymphocytes.

Chaganti, R S; German, J; Louie, E; Schonberg, S

An abnormally great amount of exhange between both sister and nonsister-but-homologous chromatids is a highly characteristic feature of cultured blood lymphocytes from individuals with Bloom's syndrome. However, a population of lymphocytes which exhibit a normal amount of exchange can be detected in...

DRIVER (German)


Balancing Immunity, Autoimmunity, and Self-tolerance

Goodnow, C. C.; New York Academy of Sciences; Institute of Rheumatology of Prague

German National Library of Science and Technology (GetInfo) (German)


Abnormal immune responses of Bloom's syndrome lymphocytes in vitro.

Hütteroth, T H; German, J; Litwin, S D

Bloom's syndrome is a rare autosmal recessive disorder, first characterized by growth retardation and asum-sensitive facial telangiectasia and more recently demonstarted to have increased chromosome instability, a predisposition to malignancy, and increased susecptibitily to infection. The present r...

DRIVER (German)


A Manyfold Increase in Sister Chromatid Exchanges in Bloom's Syndrome Lymphocytes

Chaganti, R. S. K.; German, James; Schonberg, S.

Dividing cells from persons with Bloom's syndrome, an autosomal recessive disorder of growth, exhibit increased numbers of chromatid breaks and rearrangements. A highly characteristic feature of the chromosome instability in this syndrome is the tendency for exchanges to occur between chromatids of ...

DRIVER (German)