Sample records for BLUTZELLEN (blood cells)

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The Kallikrein-Related Peptidases hK2 and PSA with Emphasis on Genetic Variation, Secretion, and Sperm Motility

Sävblom, Charlotta

Prostate-specific antigen (PSA) and human glandular kallikrein 2 (hK2) are secreted by the prostate into seminal plasma and through leakage into blood. This leakage increases rapidly in prostate disease, and PSA is used worldwide as a marker of prostate cancer. PSA is activated in vitro by hK2, and ...

DRIVER (German)


Somatic intragenic recombination within the mutated locus BLM can correct the high sister-chromatid exchange phenotype of Bloom syndrome cells.

Alhadeff, B; Ellis, N A; Proytcheva, M; Lennon, D J; Henderson, E E; German, J

Cells from persons with Bloom syndrome feature an elevated rate of sister-chromatid exchange (SCE). However, in some affected persons a minority of blood lymphocytes have a normal SCE rate. Persons who inherit the Bloom syndrome gene BLM identical by descent from a common ancestor very rarely exhibi...

DRIVER (German)


Molekulare Analyse von Tumorsuppressorgen-Kandidaten auf Chromosom 10 in Tumoren des Nervensystems

Köhler, Benjamin

Deletionen des Chromosoms 10 stellen eine häufige Veränderung in unterschiedlichen Tumoren des Nervensystems dar. Sie finden sich u.a. in der Mehrzahl der Glioblastome, aber auch in Subgruppen von atypischen und anaplastischen Meningeomen sowie Medulloblastomen. Der häufige Verlust von genetischem M...

DRIVER (German)


Molecular characterization of a novel form of (A gamma delta beta)zero-thalassemia deletion with a 3' breakpoint close to those of HPFH-3 and HPFH-4: insights for a common regulatory mechanism.

Stamatoyannopoulos, G; Anagnou, N P; Nienhuis, A W; Papayannopoulou, T

We have molecularly characterized a novel (A gamma delta beta)zero-thalassemia associated with increased synthesis of HbF in three members of a German family. The levels of HbF in the peripheral blood red cells of the heterozygotes ranged between 9.9% and 12.5% with a heterocellular distribution in ...

DRIVER (German)


Experimental treatment of stroke in spontaneously hypertensive rats by CD34+ and CD34- cord blood cells

Boltze, J.; Kowalski, I.; Geiger, K.; Reich, D.; Gunther, A.; Buhrle, C.; Egger, D.; Kamprad, M.; Emmrich, F.

Obwohl humanes Nabelschnurblut als Quelle von Stammzellen für experimentelle Therapien von Erkrankungen des Zentralnervensystems derzeit intensiv untersucht wird, ist noch wenig über die zellulären Prozesse bekannt, die der funktionellen Verbesserung von Ausfallerscheinungen zugrunde liegen. In der ...

DRIVER (German)


Evidence for increased in vivo mutation and somatic recombination in Bloom's syndrome.

German, J; Langlois, R G; Jensen, R H; Bigbee, W L

The glycophorin A assay was used to estimate the frequency of mutations that accumulate in vivo in somatic cells of persons with Bloom's syndrome (BS). This assay measures the frequency in persons of blood type MN of variant erythrocytes that lack the expression of one allelic form of glycophorin A,...

DRIVER (German)


Calcium metabolism and breast cancer risk

Almquist, Martin

Emerging evidence suggests that calcium and its regulating hormones, i.e. vitamin D and parathyroid hormone (PTH), affect breast cancer risk. The associations between serum calcium levels and breast cancer risk, between serum calcium levels and known risk factors of breast cancer, and between serum...

DRIVER (German)