Sample records for ADDUKTE (adducts)
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1

Arbeitsgruppe "DNA-Addukte"

Schell, C.; Werfel, U.; Universitatsklinik Essen; Institut fur Hygiene und Arbeitsmedizin
1997-01-01

German National Library of Science and Technology (GetInfo) (German)

100

The genotoxic air pollutant 3-nitrobenzanthrone and its reactive metabolite N-hydroxy-3-aminobenzanthrone lack initiating and complete carcinogenic activity in NMRI mouse skin.

Schmeiser, Heinz H.; Furstenberger, Gerhard; Takamura-Enya, Takeji; Phillips, David H.; Arlt, Volker M.

3-Nitrobenzanthrone (3-NBA), a genotoxic mutagen found in diesel exhaust and ambient air pollution and its active metabolite N-hydroxy-3-aminobenzanthrone (N-OH-3-ABA) were tested for initiating and complete carcinogenic activity in the NMRI mouse skin carcinogenesis model. Both compounds were found...

DRIVER (German)

102

Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy.

Stiborova, Marie; Frei, Eva; Arlt, Volker M.; Schmeiser, Heinz H.

Aristolochic acid (AA), a naturally occurring nephrotoxin and carcinogen, is associated with tumor development in patients suffering from Chinese herbs nephropathy (now termed aristolochic acid nephropathy, AAN) and may also be a cause for the development of a similar type of nephropathy, the Balkan...

DRIVER (German)

103

ECNIS-sponsored workshop on biomarkers of exposure and cancer risk: DNA damage and DNA adduct detection and 6th GUM-32P-postlabelling workshop, German Cancer Research Center, Heidelberg, Germany, 29-30 September 2006.

Arlt, Volker M.; Frei, Eva; Schmeiser, Heinz H.

Of all the chemicals classified as carcinogenic to humans by the International Agency for Research on Cancer (IARC), 90% exert their biological effects through binding of their metabolically activated intermediates to DNA forming covalent DNA adducts. As a consequence DNA adducts are generally consi...

DRIVER (German)

104

3-aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone, induces biotransformation enzymes in rat kidney and lung.

Stiborova, Marie; Dracinska, Helena; Martinkova, Marketa; Mizerovska, Jana; Hudecek, Jiri; Hodek, Petr; Liberda, Jiri

3-aminobenzanthrone (3-ABA) is the metabolite of the carcinogenic air pollutant 3-nitrobenzanthrone (3-NBA). 3-ABA was investigated for its ability to induce cytochrome P450 1A1 (CYP1A1) and NAD(P)H:quinone oxidoreductase (NQO1) in kidney and lung of rats, and for the influence of such induction on ...

DRIVER (German)